171,702 results match your criteria Pituitary Microadenomas


Thyroid Sequelae of Pediatric Cancer Therapy.

Horm Res Paediatr 2018 Dec 12:1-14. Epub 2018 Dec 12.

The hypothalamic-pituitary-thyroid axis is a common site of unintended, acquired disease either during or after the treatment of cancer. Children treated with external radiation therapy are at the highest risk for developing a thyroid-related late effect, but thyroid dysfunction and second primary thyroid neoplasms can also occur after treatment with radiopharmaceutical agents such as 131I-metaiodobenzylguanidine. Increasingly recognized is the development of early thyroid dysfunction as an off-target consequence of the more novel cancer therapeutics such as the tyrosine kinase inhibitors and immune checkpoint inhibitors. Read More

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December 2018
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Evaluation of bendable surgical suction devices made of shape-memory alloy for the endonasal transsphenoid removal of pituitary tumors.

Ear Nose Throat J 2018 Dec;97(12):413-416

Department of Medical Engineering, Fraunhofer Institute for Machine Tools and Forming Technology, Nöthnitzer Straße 44, 01187 Dresden, Germany.

In minimally invasive surgeries, it can be difficult to reach desired anatomic areas with rigid instruments, especially when obstacles are present in the surgical corridor (e.g., during transnasal pituitary surgery). Read More

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December 2018

Salivary Biomarkers of Parenting Stress in Mothers Under Community Criminal Justice Supervision.

Nurs Res 2019 Jan/Feb;68(1):48-56

Jenna K. Rieder, BA, is Research Assistant, The Graduate Center, The City University of New York, NY. Lorie S. Goshin, PhD, RN, is Assistant Professor; and D.R. Gina Sissoko, BA, is Research Assistant, Hunter College, The City University of New York, NY. Olena Kleshchova, MS, is Research Assistant, The Graduate Center, The City University of New York, NY. Mariann R. Weierich, PhD, is Associate Professor, Hunter College, The City University of New York, NY.

Background: Community criminal justice supervised mothers are an underserved population who experience high rates of psychological distress and unique parenting challenges, but little is known about physiological stress system function in this population.

Objective: We tested the salivary biomarkers of the sympathetic nervous system (SNS) and hypothalamic-pituitary-adrenal (HPA) axis function as predictors of subjective maternal stress.

Method: We recruited 23 mothers (age: M = 35. Read More

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December 2018

Cabergoline in the Management of Residual Nonfunctioning Pituitary Adenoma: A Single-Center, Open-Label, 2-Year Randomized Clinical Trial.

Am J Clin Oncol 2018 Dec 11. Epub 2018 Dec 11.

Division of Functional Neurosurgery, Institute of Psychiatry-IPq, Hospital das Clinicas, FMUSP.

Background: Complete tumor removal by transsphenoidal surgery is usually difficult for large nonfunctioning pituitary adenomas (NFPAs). A validated medical treatment may be useful for their management. This study evaluates the clinical efficacy of the dopaminergic agonist cabergoline for residual NFPA. Read More

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December 2018

Mechanisms of disease: The endocrinology of obstructive sleep apnoea.

Eur J Endocrinol 2018 Dec 1. Epub 2018 Dec 1.

A Tahrani, University of Birmingham, Institute of Metabolism and Systems Research, Birmingham, United Kingdom of Great Britain and Northern Ireland.

Obstructive sleep apnoea (OSA) is a common disorder that is associated with serious co-morbidities with a negative impact on quality of life, life expectancy and health costs. As OSA is related to obesity and is associated with sleep disruption, increased inflammation and oxidative stress, it is not surprising that OSA has an impact on the secretion of multiple hormones and is implicated in the development of many endocrine conditions. On the other hand, many endocrine conditions that can affect obesity and/or upper airways anatomy and stability have been implicated in the development or worsening of OSA. Read More

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December 2018

MRI T2 signal intensity and tumor response in patients with GH-secreting pituitary macroadenoma: PRIMARYS post-hoc analysis.

Eur J Endocrinol 2018 Dec 1. Epub 2018 Dec 1.

P Caron, Department of Endocrinology and Metabolic Diseases, Centre Hospitalier Universitaire Larrey, Toulouse, France.

Objective Pituitary adenoma MRI T2 signal intensity associates with tumor characteristics including responsiveness to somatostatin analogs (SSAs). These analyses determined whether baseline T2 signal intensity predicts response to primary medical treatment with long-acting SSA. Design Post-hoc analyses of the prospective multicenter, open-label, single-arm PRIMARYS study in which patients with treatment-naïve GH-secreting pituitary macroadenomas received fixed-dose lanreotide autogel (120mg) every 4-weeks for 48-weeks. Read More

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December 2018

Activin A in Mammalian Physiology.

Physiol Rev 2019 Jan;99(1):739-780

Department of Morphology, Universidade Federal de Minas Gerais , Belo Horizonte , Brazil ; Department of Experimental and Clinical Medicine, Università Politecnica delle Marche , Ancona , Italy ; Department of Obstetrics and Gynecology, Universidade Federal de Minas Gerais , Belo Horizonte , Brazil ; Department of Molecular and Developmental Medicine, Obstetrics and Gynecological Clinic, University of Siena , Siena , Italy ; and Department of Biomedical, Experimental and Clinical Sciences, Division of Obstetrics and Gynecology, University of Florence, Careggi University Hospital , Florence , Italy.

Activins are dimeric glycoproteins belonging to the transforming growth factor beta superfamily and resulting from the assembly of two beta subunits, which may also be combined with alpha subunits to form inhibins. Activins were discovered in 1986 following the isolation of inhibins from porcine follicular fluid, and were characterized as ovarian hormones that stimulate follicle stimulating hormone (FSH) release by the pituitary gland. In particular, activin A was shown to be the isoform of greater physiological importance in humans. Read More

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January 2019

Leptin and its actions on reproduction in males.

Asian J Androl 2018 Dec 11. Epub 2018 Dec 11.

Department of Physiology, Faculty of Medicine, Universiti Teknologi MARA, Sungai Buloh Campus, Sg Buloh 47000, Selangor, Malaysia.

Leptin, an adipocyte-derived hormone, serves numerous physiological functions in the body, particularly during puberty and reproduction. The exact mechanism by which leptin activates the gonadotropin-releasing hormone (GnRH) neurons to trigger puberty and reproduction remains unclear. Given the widespread distribution of leptin receptors in the body, both central and peripheral mechanisms involving the hypothalamic-pituitary-gonadal axis have been hypothesized. Read More

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December 2018
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[68Ga]-Dota Peptide Pet/Ct In Neuroendocrine Tumors: Main Clinical Applications.

Curr Radiopharm 2018 Dec 11. Epub 2018 Dec 11.

Department of Nuclear Medicine, S. Andrea Hospital, La Spezia. Italy.

Objective: Neuroendocrine neoplasms (NENs) are generally defined as rare and heterogeneous tumors. The gastrointestinal system is the most frequent site of NENs localization, however they can be found in other anatomical regions, such as pancreas, lungs, ovaries, thyroid, pituitary, and adrenal glands. Neuroendocrine neoplasms have significant clinical manifestations depending on the production of active peptide. Read More

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December 2018

Brain of the blind: transcriptomics of the golden-line cavefish brain.

Curr Zool 2018 Dec 12;64(6):765-773. Epub 2018 Jan 12.

Institute of Neuroscience, University of Oregon, Eugene, OR, USA.

The genus (golden-line barbel) includes 25 species of cave-dwelling blind fish (cavefish) and more than 30 surface-dwelling species with normal vision. Cave environments are dark and generally nutrient-poor with few predators. Cavefish of several genera evolved convergent morphological adaptations in visual, pigmentation, brain, olfactory, and digestive systems. Read More

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December 2018
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Hypothyroidism after craniospinal irradiation with proton or photon therapy in patients with medulloblastoma.

Pediatr Hematol Oncol 2018 Dec 11:1-10. Epub 2018 Dec 11.

b Texas Children's Cancer and Hematology Centers , Houston , Texas , USA.

Background: Craniospinal irradiation (CSI) often results in endocrine deficiencies in children with medulloblastoma due to irradiation of the hypothalamic-pituitary axis (HPA) or the thyroid gland. CSI with Proton radiation therapy (PRT) has the potential to decrease the risk of hypothyroidism by reduction in radiation dose to these organs. This study compares the risk for hypothyroidism in patients with medulloblastoma treated with Photon radiation therapy (XRT) or PRT. Read More

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December 2018

Cortisol Stress Reactivity to the Trier Social Stress Test in Obese Adults.

Obes Facts 2018 Dec 11;11(6):491-500. Epub 2018 Dec 11.

Objective: Approximately 600 million adults worldwide suffer from obesity. In addition to individual's eating behavior and lack of physical activity in the development of obesity and overweight, psychosocial stress as well as hormonal stress reactivity must also be considered as important contributing factors. In the current study we compared the cortisol stress response pathway in a psychosocial stress induction (Trier Social Stress Test; TSST) with obese individuals and normal-weight controls. Read More

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December 2018
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Role and mechanisms of a three-dimensional bioprinted microtissue model in promoting proliferation and invasion of growth-hormone-secreting pituitary adenoma cells.

Biofabrication 2018 Dec 11. Epub 2018 Dec 11.

Department of Mechanical Engineering, Biomanufacturing Center, Tsinghua University, Beijing, CHINA.

Growth-hormone-secreting pituitary adenoma (GHSPA) is a benign tumour with a high incidence and large economic burden, which greatly affects quality of life. The aetiological factors are yet to be clarified for GHSPA. Conventional two-dimensional (2D) monolayer culture of tumour cells cannot ideally reflect the growth status of tumours in the physiological environment, and insufficiencies of in vitro models have severely restricted the progress of cancer research. Read More

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December 2018
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Review shows that thyroid hormone substitution could benefit transient hypothyroxinaemia of prematurity but treatment strategies need to be clarified.

Acta Paediatr 2018 Dec 7. Epub 2018 Dec 7.

Department of Neonatology, University Hospitals Leuven, KU, Leuven, Belgium.

Aim: Thyroid hormones are crucial for fetal and neonatal brain development. This paper provides an overview of the normal role of thyroid hormones in fetal brain development and the pathophysiology of transient hypothyroxinaemia of prematurity (THOP). It also discusses the diagnostic and therapeutic controversies around THOP and looks at directions for future research. Read More

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December 2018
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Supraglottic Squamous Cell Carcinoma: A Population-Based Study of 22,675 Cases.

Laryngoscope 2018 Dec 11. Epub 2018 Dec 11.

Department of Otolaryngology-Head and Neck Surgery, Neurological Institute of New Jersey, Newark, New Jersey, U.S.A.

Objectives/hypothesis: The authors used the Surveillance, Epidemiology, and End Results (SEER) database to analyze epidemiological features of patients presenting with supraglottic squamous cell carcinoma (SCCa) and to evaluate treatment trends and outcomes.

Methods: The SEER database was queried for patients with supraglottic SCCa from 1973 to 2013. Information on demographics; tumor size; histologic grade; American Joint Committee on Cancer (AJCC) stage; SEER local, regional, distant stage; and treatment modality were analyzed. Read More

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December 2018
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Concurrent pituitary and adrenocortical lesions on computed tomography imaging in dogs with spontaneous hypercortisolism.

J Vet Intern Med 2018 Dec 11. Epub 2018 Dec 11.

Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.

Background: Spontaneous hypercortisolism or Cushing's syndrome in dogs is either pituitary or adrenal dependent, but concurrent pituitary and adrenal hypercortisolism also has been reported.

Objective: To determine how often concurrent pituitary and adrenal lesions are present in dogs with spontaneous hypercortisolism.

Animals: Two hundred one client-owned dogs with spontaneous hypercortisolism. Read More

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December 2018

The application of nasoseptal "rescue" flap technique in endoscopic transsphenoidal pituitary adenoma resection.

Neurosurg Rev 2018 Dec 11. Epub 2018 Dec 11.

Department of Neurosurgery, Qilu Hospital, Shandong University, 107 Wenhua Western Rd., Jinan, 250012, Shandong, China.

To explore the reliability and superiority of nasoseptal "rescue" flap technique in neuroendoscopic transnasal pituitary adenoma resection. Retrospective clinical analysis of 113 cases of endoscopic transsphenoid pituitary adenoma resection with the application of nasoseptal "rescue" flap technology. The reliability and the superiority of the technique were evaluated according to the duration of nasal cavity and sphenoid sinus stage, the incidence of postoperative anosmia, and cerebrospinal rhinorrhea. Read More

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December 2018

Endoscopic endonasal resection of symptomatic Rathke cleft cysts: clinical outcomes and prognosis.

Neurosurg Rev 2018 Dec 10. Epub 2018 Dec 10.

Department of Neurosurgery, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, China.

The aim of this study is to investigate the clinical presentation and outcomes associated with endoscopic endonasal resection of Rathke cleft cysts (RCCs). The authors retrospectively studied a series of 13 patients who were diagnosed with RCCs after endoscopic endonasal resection at the Second Xiangya Hospital between June 2016 and December 2017. All 13 patients (8 women) underwent a purely endoscopic endonasal approach (EEA) for fenestration and aspiration of RCCs with excision of the cystic wall. Read More

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December 2018
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Proton Sensitivity of Corticotropin-Releasing Hormone Receptor 1 Signaling to Proopiomelanocortin in Male Mice.

Endocrinology 2018 Dec 6. Epub 2018 Dec 6.

Pituitary Center, Cedars-Sinai Medical Center, Los Angeles, CA.

As an acidic cellular microenvironment is engendered by inflammation and may determine cell differentiation, we elucidated the impact of acidic conditions on induction of POMC expression. Here, we demonstrate mechanisms for proton-sensitivity of corticotropin releasing hormone receptor 1 (CRHR1) signaling to POMC and adrenocorticotropin (ACTH) production. Low pH (6. Read More

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December 2018

[Spontaneous remission of acromegaly and Cushing's disease in older patients. Report of two cases].

Rev Med Chil 2018 Jul;146(7):933-937

Departamento de Neurología y Neurocirugía, Hospital Clínico de la Universidad de Chile, Santiago, Chile.

Pituitary diseases such as acromegaly and Cushing's disease require surgical or medical therapy. In some functioning pituitary tumors, a spontaneous remission of hormonal hypersecretion is observed, mainly associated to apoplexy or pituitary infarction. We report the evolution of two female patients older than 70 years at the time of diagnosis, with multiple comorbidities. Read More

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July 2018
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hCG production by mucinous adenocarcinoma of the ovary in a reproductive aged woman.

Gynecol Oncol Rep 2018 Nov 31;26:102-104. Epub 2018 Oct 31.

Division of Gynecologic Oncology, The University of Iowa Hospitals and Clinics, United States.

When elevated serum hCG is discovered during the work up of a gynecologic tumor, it is paramount to identify the source of hCG prior to initiation of treatment. Potential sources of hCG include viable intrauterine pregnancy, ectopic pregnancy, miscarriage, gestational trophoblastic disease, pituitary hCG production, phantom hCG (heterophilic antibody interference), and tumor production. Here, we present a case of elevated hCG in a young women with a large complex pelvic mass. Read More

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November 2018

Usefulness of neuroimaging and immunohistochemical study for accurate diagnosis of chordoid glioma of the third ventricle: A case report and review of the literature.

Surg Neurol Int 2018 2;9:226. Epub 2018 Nov 2.

Department of Neurosurgery, Ehime University School of Medicine, 454 Shitsukawa, Toon, Ehime 791-0295, Japan.

Background: Chordoid glioma of the third ventricle is a rare neuroepithelial tumor characterized by a unique histomorphology within the third ventricular region, but with radiological and histopathological features mimicking benign lesions such as meningioma. We report a case of chordoid glioma of the third ventricle and suggest a useful indicator for accurate diagnosis.

Case Description: A previously healthy 46-year-old woman was admitted to our hospital with mild headache. Read More

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November 2018

A clinically functioning gonadotroph adenoma presenting with abdominal pain, ovarian hyperstimulation and fibromatosis.

Endocrinol Diabetes Metab Case Rep 2018 Dec 11;2018. Epub 2018 Dec 11.

Southmead Hospital, North Bristol NHS Trust, Westbury-on-Trym, Bristol, UK.

Pituitary adenomas can be classified as functioning or non-functioning adenomas. Approximately 64% of clinically non-functioning pituitary adenomas are found to be gonadotroph adenomas on immunohistochemistry. There are reported cases of gonadotroph adenomas causing clinical symptoms, but this is unusual. Read More

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December 2018

A Novel, Synthetic, Neuroactive Steroid Is Effective at Decreasing Depression-Like Behaviors and Improving Maternal Care in Preclinical Models of Postpartum Depression.

Front Endocrinol (Lausanne) 2018 23;9:703. Epub 2018 Nov 23.

Neuroscience Department, Tufts University School of Medicine, Boston, MA, United States.

Preclinical testing of treatments for postpartum depression (PPD) has been limited due to the lack of available animal models of such a complex disorder. To address this limitation, our laboratory has generated unique preclinical mouse models that exhibit abnormal postpartum behaviors. Mice with a loss or reduction in the expression of the GABA receptor (GABAR) δ subunit ( or , respectively) and mice that lack the K/Cl co-transporter, KCC2, specifically in corticotropin-releasing hormone (CRH) neurons (KCC2/Crh mice) exhibit depression-like behaviors restricted to the postpartum period and deficits in maternal care, which serve as useful tools for testing novel therapeutic compounds. Read More

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November 2018

Integration of Proteomics and Metabolomics Revealed Metabolite-Protein Networks in ACTH-Secreting Pituitary Adenoma.

Front Endocrinol (Lausanne) 2018 23;9:678. Epub 2018 Nov 23.

Beijing Neurosurgical Institute, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.

An effective treatment for the management of adrenocorticotropic hormone-secreting pituitary adenomas (ACTH-PA) is currently lacking, although surgery is a treatment option. We have integrated information obtained at the metabolomic and proteomic levels to identify critical networks and signaling pathways that may play important roles in the metabolic regulation of ACTH-PA and therefore hopefully represent potential therapeutic targets. Six ACTH-PAs and seven normal pituitary glands were investigated via gas chromatography-mass spectrometry (GC-MS) analysis for metabolomics. Read More

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November 2018

Intergenerational Transmission of DNA Methylation Signatures Associated with Early Life Stress.

Curr Genomics 2018 Dec;19(8):665-675

1Department of Genetic Medicine and Development, University of Geneva Hospitals and Faculty of Medicine, Geneva, Switzerland; 2Department of Child & Adolescent Psychiatry, University of Geneva Hospitals and Faculty of Medicine, Geneva, Switzerland; 3Department of Child & Adolescent Psychiatry, New York University School of Medicine, New York, NY, USA.

Early life stress in humans (i.e. maltreatment, violence exposure, loss of a loved one) and in rodents (i. Read More

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December 2018

How Stress Gets Under the Skin: Early Life Adversity and Glucocorticoid Receptor Epigenetic Regulation.

Curr Genomics 2018 Dec;19(8):653-664

Department of Psychology, Northwestern University, Evanston, IL60208, USA.

Early life adversity is associated with both persistent disruptions in the hypothalamic-pituitary-adrenal (HPA) axis and psychiatric symptoms. Glucocorticoid receptors (GRs), which are encoded by the NR3C1 gene, bind to cortisol and other glucocorticoids to create a negative feedback loop within the HPA axis to regulate the body's neuroendocrine response to stress. Excess methylation of a promoter sequence within NR3C1 that attenuates GR expression, however, has been associated with both early life adversity and psychopathology. Read More

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December 2018

Light-dark influence on enkephalinase activity in hypothalamus and pituitary.

Neuro Endocrinol Lett 2018 Oct 12;39(4):277-280. Epub 2018 Oct 12.

Unit of Physiology, University of Jaén, 23071 Jaén, Spain.

Objectives: Enkephalins functions are partly modulated by enkephalinases especially membrane-bound alanyl aminopeptidase (EC-3.4.11. Read More

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October 2018

Silent somatotropinomas.

Minerva Endocrinol 2018 Dec 7. Epub 2018 Dec 7.

Pathology Department, Hospital General Universitario de Alicante, Alicante, Spain.

Silent somatotroph pituitary neuroendocrine tumors (or silent growth hormone pituitary neuroendocrine tumors, SGH-PitNET) are neoplasias with positive immunostaining for growth hormone (GH), in patients with no signs and symptoms of acromegaly nor biochemical evidence of GH hypersecretion. From a clinical stand-point they are considered and managed as non-functioning pituitary tumors, since they usually come to evidence due to mass-effects (headache, visual impairment, hypopituitarism) or as asymptomatic pituitary incidentalomas. SGH-PitNET have deserved little attention in the medical literature, and no specific guidelines exist regarding their management. Read More

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December 2018

Pathological markers of somatotroph pituitary neuroendocrine tumors (PitNET)s predicting the response to medical treatment.

Minerva Endocrinol 2018 Dec 7. Epub 2018 Dec 7.

Lyon 1, Université de Lyon, Lyon, France -

Acromegaly is mainly due to the somatotroph pituitary neuroendocrine tumors (PitNET)s. These have been subtyped into densely granulated (DG) and sparsely granulated (SG) tumors, which differ in clinical, histological and biological characteristics and in response to somatostatin analogs (SA)s. The variable remission rate after surgical resection, as first line treatment, has increased interest in identifying pathological markers to better predict the response to medical treatment. Read More

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December 2018

Antipsychotics and pituitary tumors: an analysis of the European pharmacovigilance database (EudraVigilance).

Int Clin Psychopharmacol 2018 Dec 10. Epub 2018 Dec 10.

Basque Pharmacovigilance Unit, Galdakao-Usánsolo Hospital, Galdakao.

One of the possible long-term consequences of antipsychotic-induced hyperprolactinemia is the development of pituitary tumors - prolactinomas. So far, two pharmacovigilance studies of spontaneous adverse event report databases have suggested an increased risk, whereas a longitudinal study carried out with risperidone showed no evidence of increased risk of tumors with mass effect. Besides, information on amisulpride and paliperidone is lacking. Read More

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December 2018

Inhibin B: are modified ranges needed for orchiectomised testicular cancer patients?

Asian J Androl 2018 Dec 7. Epub 2018 Dec 7.

Laboratory of Seminology, Sperm Bank "Loredana Gandini", Department of Experimental Medicine, Medical Pathophysiology Section, "Sapienza" University of Rome, Rome 00161, Italy.

Inhibin B is a gonadal hormone that downregulates the pituitary production of follicle-stimulating hormone (FSH). In recent years, inhibin B has proved to be an excellent marker of spermatogenesis and even a predictive factor for the recovery of fertility in patients undergoing orchiectomy and antineoplastic treatments. We propose to study inhibin B levels in orchiectomised testicular cancer patients, in order to identify a minimum value representative of normal semen quality. Read More

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December 2018

Long-acting intramuscular ACTH stimulation test for the diagnosis of secondary adrenal insufficiency in children.

J Pediatr Endocrinol Metab 2018 Dec 7. Epub 2018 Dec 7.

Division of Pediatric Endocrinology, Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India.

Background The diagnosis of adrenal insufficiency (AI) is based on the basal and stimulated levels of serum cortisol in response to the short Synacthen test (SST). In patients with secondary AI (SAI) due to hypothalamic-pituitary-adrenal (HPA) axis defects, the SST has been validated against the insulin tolerance test (ITT), which is the gold standard. However, injection Synacthen is not easily available in some countries, and endocrinologists often use Acton-Prolongatum (intramuscular [IM] long-acting adrenocorticotropic hormone [ACTH]) in place of Synacthen. Read More

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December 2018

Germline and mosaic mutations causing pituitary tumours: genetic and molecular aspects.

J Endocrinol 2019 Feb;240(2):R21-R45

Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine, Queen Mary University of London, London, UK.

While 95% of pituitary adenomas arise sporadically without a known inheritable predisposing mutation, in about 5% of the cases they can arise in a familial setting, either isolated (familial isolated pituitary adenoma or FIPA) or as part of a syndrome. FIPA is caused, in 15-30% of all kindreds, by inactivating mutations in the AIP gene, encoding a co-chaperone with a vast array of interacting partners and causing most commonly growth hormone excess. While the mechanisms linking AIP with pituitary tumorigenesis have not been fully understood, they are likely to involve several pathways, including the cAMP-dependent protein kinase A pathway via defective G inhibitory protein signalling or altered interaction with phosphodiesterases. Read More

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February 2019

Familial ROBO1 deletion associated with ectopic posterior pituitary, duplication of the pituitary stalk and anterior pituitary hypoplasia.

J Pediatr Endocrinol Metab 2018 Dec 11. Epub 2018 Dec 11.

UOC Neurochirurgia, Istituto Giannina Gaslini, Genoa, Italy.

Background The genetic causes of abnormal pituitary development have been extensively studied in the last few years. ROBO1 is involved in neurogenesis and axon guidance. Loss-of-function variants in ROBO1 have been associated with pituitary stalk interruption syndrome (PSIS), suggesting that its haploinsufficiency could impair the guidance of hypothalamic axons to the pituitary gland leading to developmental abnormalities. Read More

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December 2018

Resistance to thyroid hormone-beta co-existing with partially empty sella in a Jordanian male.

Endocrinol Diabetes Metab Case Rep 2018 Dec 5;2018. Epub 2018 Dec 5.

ObesityEndocrine and Metabolism Centre, King Fahad Medical City, Riyadh, Kingdom of Saudi Arabia.

Resistance to thyroid hormone-beta (RTHbeta) is a rare inherited syndrome characterized by variable reduced tissue responsiveness to the intracellular action of triiodothyronine (T3), the active form of the thyroid hormone. The presentation of RTHbeta is quite variable and mutations in the thyroid hormone receptor beta (THR-B) gene have been detected in up to 90% of patients. The proband was a 34-year-old Jordanian male who presented with intermittent palpitations. Read More

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December 2018

Metabolic syndrome is a sequela of radiation exposure in hypothalamic obesity among survivors of childhood brain tumors.

J Investig Med 2018 Dec 9. Epub 2018 Dec 9.

University of Texas Southwestern Medical Center, Dallas, Texas, USA.

Survivors of childhood brain tumors may be at risk for early onset of metabolic syndrome, possibly secondary to surgery and/or radiation exposure. This study examines effects of radiation exposure to hypothalamus-pituitary-adrenal axis (HPA) on metabolic risk among survivors of childhood brain tumors. One hundred forty-two met inclusion criteria; 60 had tumor surgery plus radiation exposure (1 Gray (Gy)) to HPA. Read More

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December 2018

Proton therapy for treatment of intracranial benign tumors in adults: A systematic review.

Cancer Treat Rev 2018 Dec 1;72:56-64. Epub 2018 Dec 1.

Radiation Oncology Department, Centre François Baclesse, Caen, France; Archade, Advanced Resource Center for Hadrontherapy in Europe, Caen, France; Normandy University, Université de Caen Basse Normandie, Caen, France; Laboratoire de Physique Corpusculaire, Caen, France.

Introduction: The depth-dose distribution of a proton beam, materialized by the Bragg peak makes it an attractive radiation modality as it reduces exposure of healthy tissues to radiations, compared with photon therapy Prominent indications, based on a long-standing experience are: intraocular melanomas, low-grade skull-base and spinal canal malignancies. However, many others potential indications are under investigations such as the benign morbid conditions that are compatible with an extended life-expectancy: low grade meningiomas, paragangliomas, pituitary adenomas, neurinomas craniopharyngioma or recurrent pleomorphic adenomas.

Materials: Given the radiation-induced risk of secondary cancer and the potential neurocognitive and functional alteration with photonic radiotherapy, we systematically analyzed the existing clinical literature about the use of proton therapy as an irradiation modality for cervical or intracranial benign tumors. Read More

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December 2018

Resting amygdala connectivity and basal sympathetic tone as markers of chronic hypervigilance.

Psychoneuroendocrinology 2018 Nov 26;102:68-78. Epub 2018 Nov 26.

Hunter College, The City University of New York, 695 Park Avenue, New York, NY 10065, USA; The Graduate Center, The City University of New York, 365 Fifth Avenue, New York, NY 10016, USA. Electronic address:

Background: Chronic hypervigilance, a state of sustained alertness and hyperarousal in the absence of threat, has been shown to predict poorer clinical outcomes post-trauma. An exaggerated and persistent amygdala alerting response to affective information has been proposed as a reactivity-based, and thus indirect, marker of hypervigilance. However, because chronic hypervigilance is a persistent rather than reactive state, it should be directly observable under resting-state conditions without the need for exposure to affectively charged stimuli. Read More

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November 2018

Fertility after transsphenoidal surgery in patients with prolactinomas: A meta-analysis.

Clin Neurol Neurosurg 2018 Dec 1;176:53-60. Epub 2018 Dec 1.

Computational Neuroscience Outcomes Center, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; School of Pharmacy, MCPHS University, Boston, MA, USA(3). Electronic address:

Pituitary prolactinomas in women often lead to amenorrhea, galactorrhea, or infertility. The purpose of this study was to evaluate the effectiveness of transsphenoidal surgery (TSS) in restoring fertility in women with proloactinomas. A systematic search of the literature was conducted in accordance with PRISMA guidelines through 6/13/2017. Read More

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December 2018

Expression of gonadotropin subunit and gonadotropin receptor genes in wild female new zealand shortfinned eel (Anguilla australis) During yellow and silver stages.

Gen Comp Endocrinol 2018 Dec 6. Epub 2018 Dec 6.

Department of Zoology, University of Otago, 340 Great King Street, PO Box 56, Dunedin 9054, New Zealand.

Despite tremendous importance of follicle-stimulating hormone (Fsh) and luteinizing hormone (Lh) as primary controllers of reproductive development, information on the expression profiles of the genes encoding gonadotropin subunits and gonadotropin receptors (Fshr and Lhr) in wild eels are essentially non-existent. This study investigated pituitary fshb and lhb mRNA levels and ovarian fshr and lhr mRNA levels of wild shortfinned eels, Anguilla australis at different stages of oogenesis. Protein expression of Fsh in the pituitary was also quantified and visualized using slot blot and immunohistochemistry. Read More

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December 2018

Nasal morbidity and quality of life after endoscopic trans-sphenoidal surgery: a single-center, prospective study.

World Neurosurg 2018 Dec 5. Epub 2018 Dec 5.

Unit of Neurosurgery, University of Brescia, Brescia, Italy.

Objective: The aim of this study was to assess nasal morbidity of endoscopic trans-sphenoidal approaches (ETA) for treatment of sellar and parasellar diseases through evaluation of quality of life (QoL) and nasal function. The impact of different ETA, according to extent and reconstruction technique, was also studied.

Methods: Patients undergoing ETA for treatment of sellar or parasellar lesions were prospectively recruited and examined preoperatively and at 6 months after surgery according to the following work-up: nasal endoscopy, rhinomanometry, acoustic rhinometry (AcR), University of Pennsylvania Smell Identification Test (UPSIT), Anterior Skull Base Nasal Inventory - 12 (ASK-12), Sino-nasal Outcome Test - 22 (SNOT-22), and Short Form Health Survey - 36 (SF-36). Read More

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December 2018

CHIPS-Child: Testing the developmental programming hypothesis in the offspring of the CHIPS trial.

Pregnancy Hypertens 2018 Oct 19;14:15-22. Epub 2018 May 19.

Obstetrics and Gynaecology, Universite de Sherbrooke, Canada. Electronic address:

Objectives: As a follow-up to the CHIPS trial (Control of Hypertension In Pregnancy Study) of 'less tight' (versus 'tight') control of maternal blood pressure in pregnancy, CHIPS-Child investigated potential developmental programming of maternal blood pressure control in pregnancy, by examining measures of postnatal growth rate and hypothalamic-pituitary adrenal (HPA) axis activation.

Methods: CHIPS follow-up was extended to 12 ± 2 months corrected post-gestational age for anthropometry (weight, length, head/waist circumference). For eligible children with consent for a study visit, we collected biological samples (hair/buccal samples) to evaluate HPA axis function (hair cortisol levels) and epigenetic change (DNA methylation analysis of buccal cells). Read More

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October 2018

Psi Chi/APA Edwin B. Newman Graduate Research Award: Cope Feurer.

Authors:

Am Psychol 2018 Dec;73(9):1256-1258

The Edwin B. Newman Graduate Research Award is given jointly by Psi Chi and APA. The award was established to recognize young researchers at the beginning of their professional lives and to commemorate both the 50th anniversary of Psi Chi and the 100th anniversary of psychology as a science (dating from the founding of Wundt's laboratory). Read More

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December 2018

Hypercortisolism in Newly Diagnosed Type 2 Diabetes: A Prospective Study of 384 Newly Diagnosed Patients.

Horm Metab Res 2018 Dec 6. Epub 2018 Dec 6.

Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark.

Cross-sectional studies in small and selected populations report a high prevalence of hypercortisolism in patients with type 2 diabetes (T2D), which could have therapeutic implications, if confirmed. We therefore estimated the prevalence of hypercortisolism in a large and unselected cohort of recently diagnosed T2D patients. Consecutive patients with recently diagnosed T2D first underwent an overnight dexamethasone (1 mg) suppression test (OD). Read More

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December 2018
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Bisphenol F causes disruption of gonadotropin-releasing hormone neural development in zebrafish via an estrogenic mechanism.

Neurotoxicology 2018 Dec 3;71:31-38. Epub 2018 Dec 3.

Department of Biology, Neuroscience Program, University of Puget Sound, Tacoma, Washington, USA. Electronic address:

Gonadotropin releasing hormone (GnRH) neurons in the brain are the main controllers of reproduction and reproductive behavior in most vertebrates, and are susceptible to endocrine disruption by different bisphenols. While the endocrine disrupting properties of bisphenol A have been well documented, commonly used analogues such as bisphenol F (BPF) are not as well studied. In this study we examined the effects of early, low-dose, chronic BPF exposure on the development of the GnRH neural system in the zebrafish embryo. Read More

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December 2018