1,345 results match your criteria Pituitary Macroadenomas


Combined supra-infrasellar approach to pituitary macroadenoma with oculomotor cistern extension: surgical strategy and experience.

Acta Neurochir (Wien) 2019 Mar 12. Epub 2019 Mar 12.

Department of Neurosurgery, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma, 371-8511, Japan.

Background: Oculomotor cistern extension (OMCE) of pituitary adenoma through the oculomotor triangle may be one of the major characteristics of multi-lobulated adenoma. The OMCE may be hard to remove only through the endonasal approach.

Method: We applied the simultaneous combined supra-infrasellar approach to remove pituitary adenoma with relatively large OMCE. Read More

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http://link.springer.com/10.1007/s00701-019-03869-6
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http://dx.doi.org/10.1007/s00701-019-03869-6DOI Listing
March 2019
1 Read

Endoscopic Endonasal Excision of Large and Giant Pituitary Adenomas: Radiological and Intraoperative Correlates of the Extent of Resection.

World Neurosurg 2019 Mar 8. Epub 2019 Mar 8.

Professor and Chairman, Neurosurgery Department, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China.

Background: Despite the superb visualization offered by the endoscopic endonasal transsphenoidal approach, resection rates of large and giant pituitary adenomas still remain much lower than those of smaller macroadenomas. Various tumor characteristics influence the extent of resection (EOR) and are variably reported. Further understanding of these factors is mandatory to improve the current results. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.02.151DOI Listing

Use of the Artemis Neuro Evacuation Device in the Resection of a Pituitary Adenoma: Initial Technical Note.

World Neurosurg 2019 Mar 1. Epub 2019 Mar 1.

University of Kentucky Department of Neurological Surgery; University of Kentucky Department of Neurology; University of Kentucky Department of Radiology; University of Kentucky Department of Neuroscience. Electronic address:

Background: Endoscopic transsphenoidal resection has become the primary approach for resection of pituitary macroadenomas. However, challenges such as narrow sinuses, dense tumor consistency, and invasion of surrounding structures exist.

Method: We report a case in which the Artemis Neuro Evacuation device was used to endonasally remove a pituitary macroadenoma with suprasellar and parasellar extensions. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.02.113DOI Listing
March 2019
1 Read

AIP and MEN1 mutations and AIP immunohistochemistry in pituitary adenomas in a tertiary referral center.

Endocr Connect 2019 Mar 1. Epub 2019 Mar 1.

A Soto, Division of Endocrinology, Virgen del Rocio University Hospital, Sevilla, Spain.

Background: Pituitary adenomas have a high disease burden due to tumor growth/invasion and disordered hormonal secretion. Germline mutations in genes such as MEN1 and AIP are associated with early onset of aggressive pituitary adenomas that can be resistant to medical therapy.

Aims: We performed a retrospective screening study using published risk criteria to assess the frequency of AIP and MEN1 mutations in pituitary adenoma patients in a tertiary-referral center. Read More

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http://dx.doi.org/10.1530/EC-19-0027DOI Listing
March 2019
1 Read

Filamin A and DRD2 expression in corticotrophinomas.

Pituitary 2019 Apr;22(2):163-169

Neuroendocrine Unit, Division of Endocrinology and Metabolism, Hospital das Clínicas & Laboratory of Cellular and Molecular Endocrinology LIM-25, University of Sao Paulo Medical School, São Paulo, SP, Brazil.

Purpose: Filamin A (FLNA) expression is related to dopamine receptor type 2 (DRD2) expression in prolactinomas. Nevertheless, in corticotrophinomas, there are few studies about DRD2 expression and no data on FLNA. Therefore, we evaluated FLNA and DRD2 expression in corticotrophinomas and their association with tumor characteristics. Read More

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http://dx.doi.org/10.1007/s11102-019-00947-xDOI Listing

Outcomes of three-Tesla magnetic resonance imaging for the identification of pituitary adenoma in patients with Cushing's disease.

Endocr J 2019 Feb 14. Epub 2019 Feb 14.

Department of Hypothalamic and Pituitary Surgery, Toranomon Hospital, Tokyo 105-8470, Japan.

Pituitary adenoma has been reported to be detectable in only 36-63% of Cushing's disease (CD) patients by magnetic resonance imaging (MRI). In this study, we investigate the outcomes and problems associated with tumor identification using 3-Tesla (3-T) MRI, which provides clearer images than ≤1.5-T MRI, in 115 patients who were initially diagnosed with CD. Read More

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http://dx.doi.org/10.1507/endocrj.EJ18-0458DOI Listing
February 2019
1 Read

Epidemiology and Management Challenges in Prolactinomas.

Neuroendocrinology 2019 Feb 7. Epub 2019 Feb 7.


Clinically relevant pituitary adenomas are present in about 1 per 1000 of the general population and prolactinomas are by far the most common clinical subtype of pituitary adenomas. Usually prolactinomas affect pre-menopausal women and present with typical symptoms of menstrual disturbance and/or galactorrhea. They are generally managed with dopamine agonists to restore fertility and to control symptoms and tumour size. Read More

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http://dx.doi.org/10.1159/000497746DOI Listing
February 2019
2 Reads

[Clinical and functional characteristics of giant pituitary adenomas in the population of patients in the Moscow region].

Zh Vopr Neirokhir Im N N Burdenko 2018 ;82(6):76-81

Moscow Regional Researh and Clinical Institute, Moscow, Russia.

Benign pituitary tumors are the most common sellar neoplasms. Lesions larger than 39 mm in the maximum dimension are called giant. They are rare, and, therefore, there are few data on the clinical and morphological features of giant pituitary tumors with different hormonal activity. Read More

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http://dx.doi.org/10.17116/neiro20188206176DOI Listing
January 2018
1 Read

Prediction of recurrence in solid nonfunctioning pituitary macroadenomas: additional benefits of diffusion-weighted MR imaging.

J Neurosurg 2019 Feb 1:1-9. Epub 2019 Feb 1.

7Department of Radiology, E-DA Hospital, E-DA Cancer Hospital, I-Shou University, Kaohsiung, Taiwan; and.

OBJECTIVEA subset of benign, nonfunctioning pituitary macroadenomas (NFMAs) has been shown to undergo early progression/recurrence (P/R) during the first years after surgical resection. The aim of this study was to determine preoperative MR imaging features for the prediction of P/R in benign solid NFMAs, with emphasis on apparent diffusion coefficient (ADC) values.METHODSWe retrospectively investigated the preoperative MR imaging features for the prediction of P/R in benign solid NFMAs. Read More

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http://dx.doi.org/10.3171/2018.10.JNS181783DOI Listing
February 2019
1 Read

Long-term effects of intracapsular debulking and adjuvant somatostatin analogs for growth hormone-secreting pituitary macroadenoma: 10 years of experience in a single institute.

World Neurosurg 2019 Feb 1. Epub 2019 Feb 1.

Department of Minimally Invasive Skull Base Neurosurgery, Neurological Institute, Taichung Veterans General Hospital, Taichung, Taiwan; Department of Physical Therapy, Hung Kuang University, Taichung, Taiwan. Electronic address:

Objective: Long-term effects of endoscopic endonasal transsphenoidal intracapsular debulking and adjuvant somatostatin analogs were evaluated in patients with growth hormone secreting pituitary macroadenomas.

Methods: We retrospectively reviewed the medical records of 45 patients with acromegalic macroadenoma who underwent endonasal endoscopic transsphenoidal intracapsular debulking and received adjuvant somatostatin analogs (octreotide) between 2006 and 2015, who had more than 1 year of follow-up. To evaluate the predictive factors for 1 year and long-term biochemical outcomes, univariate and multivariate analyses were performed. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18788750193022
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http://dx.doi.org/10.1016/j.wneu.2019.01.125DOI Listing
February 2019
5 Reads

Long term MRI surveillance of pituitary macroadenomas: gadolinium is not obligatory.

Pituitary 2019 Feb;22(1):100-102

Departments of Medical Imaging and Endocrinology, Centre Hospitalier Universitaire de Liege, Liège, Belgium.

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http://dx.doi.org/10.1007/s11102-018-00931-xDOI Listing
February 2019
1 Read

Deferred Radiotherapy After Debulking of Non-functioning Pituitary Macroadenomas: Clinical Outcomes.

Front Oncol 2018 10;8:660. Epub 2019 Jan 10.

Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, United States.

To describe the outcome for a cohort of patients with non-functioning pituitary macroadenomas (NFPMA), managed by debulking surgery with radiation therapy delayed until progression. Two hundred and sixty-seven patients were treated surgically for pituitary tumors at our institution between 1997 and 2005. One hundred and twenty-six patients met the inclusion criteria of NFPMA. Read More

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http://dx.doi.org/10.3389/fonc.2018.00660DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335347PMC
January 2019
1 Read

Quantitative assessment of secondary white matter injury in the visual pathway by pituitary adenomas: a multimodal study at 7-Tesla MRI.

J Neurosurg 2019 Jan 18:1-10. Epub 2019 Jan 18.

1Translational and Molecular Imaging Institute and.

OBJECTIVEThe objective of this study was to investigate microstructural damage caused by pituitary macroadenomas by performing probabilistic tractography of the optic tracts and radiations using 7-T diffusion-weighted MRI (DWI). These imaging findings were correlated with neuro-ophthalmological results to assess the utility of ultra-high-field MRI for objective evaluation of damage to the anterior and posterior visual pathways.METHODSProbabilistic tractography employing 7-T DWI was used to reconstruct the optic tracts and radiations in 18 patients with adenomas and in 16 healthy volunteers. Read More

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http://dx.doi.org/10.3171/2018.9.JNS182022DOI Listing
January 2019
2 Reads

Proposal and Validation of a Simple Grading Scale (TRANSSPHER Grade) for Predicting Gross Total Resection of Nonfunctioning Pituitary Macroadenomas After Transsphenoidal Surgery.

Oper Neurosurg (Hagerstown) 2019 Jan 11. Epub 2019 Jan 11.

Department of Neurosurgery, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, Arizona.

Background: A simple, reliable grading scale to better characterize nonfunctioning pituitary adenomas (NFPAs) preoperatively has potential for research and clinical applications.

Objective: To develop a grading scale from a prospective multicenter cohort of patients that accurately and reliably predicts the likelihood of gross total resection (GTR) after transsphenoidal NFPA surgery.

Methods: Extent-of-resection (EOR) data from a prospective multicenter study in transsphenoidal NFPA surgery were analyzed (TRANSSPHER study; ClinicalTrials. Read More

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http://dx.doi.org/10.1093/ons/opy401DOI Listing
January 2019
1 Read

Pituitary macroadenoma: Accuracy of apparent diffusion coefficient magnetic resonance imaging in grading tumor aggressiveness.

Neuroradiol J 2019 Apr 16;32(2):86-91. Epub 2019 Jan 16.

3 Department of Pathology and Laboratory Medicine, Kanazawa Medical University, Japan.

Purpose: The purpose of this study is to evaluate the accuracy of apparent diffusion coefficient magnetic resonance imaging in grading tumor aggressiveness using histogram apparent diffusion coefficient values.

Materials And Methods: Eighteen patients with surgically proved pituitary macroadenomas were included in this study. Diffusion-weighted imaging with single-shot echo-planar sequence at 3-T with a 32-channel head coil was performed with b values of 0 and 1000 s/mm. Read More

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http://dx.doi.org/10.1177/1971400919825696DOI Listing
April 2019
3 Reads

Empirical versus progression-guided stereotactic radiosurgery for non-functional pituitary macroadenomas after subtotal resection.

J Neurooncol 2019 Jan 12. Epub 2019 Jan 12.

Department of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan, ROC.

Objective: There is a lack of consensus regarding whether if residual non-functional macroadenomas (NFM) should undergo empirical stereotactic radiosurgery (SRS) or be monitored until tumor progression before SRS treatment. The aim of this study is to compare the risks and benefits of empirical versus progression-guided SRS for NFM after subtotal resection.

Methods: This is a retrospective study of consecutive NFM patients who subtotal surgical resection followed by SRS between 1999 and 2014. Read More

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http://dx.doi.org/10.1007/s11060-019-03095-1DOI Listing
January 2019
3 Reads

Pregnancy in acromegaly is safe and is associated with improvements in IGF-1 concentrations.

Eur J Endocrinol 2019 Apr;180(4):K21-K29

Department of Endocrinology, Beaumont Hospital, Dublin, Ireland.

Pregnancy is rarely reported in acromegaly. Many patients are diagnosed in later life and younger patients may have subfertility due to hypopituitarism. We present a case series of 17 pregnancies in 12 women with acromegaly. Read More

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http://dx.doi.org/10.1530/EJE-18-0688DOI Listing
April 2019
4 Reads

The Prognostic Roles of the Ki-67 Proliferation Index, P53 Expression, Mitotic Index, and Radiological Tumor Invasion in Pituitary Adenomas.

Endocr Pathol 2019 Mar;30(1):49-55

Department of Endocrinology and Metabolism, Ankara University Faculty of Medicine, Ankara, Turkey.

The fourth edition of the World Health Organization (WHO) classification of pituitary tumors recommended evaluation of tumor proliferation and invasion to identify aggressiveness. We aimed to assess the prognostic roles of the Ki-67 proliferation index, mitotic index, P53 expression, and cavernous sinus invasion in pituitary adenomas (PAs). Among the 601 patients who underwent transnasal/transsphenoidal adenomectomy from 2001 to 2016, 101 patients (16. Read More

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http://dx.doi.org/10.1007/s12022-018-9563-2DOI Listing
March 2019
3 Reads

MRI T2 signal intensity and tumor response in patients with GH-secreting pituitary macroadenoma: PRIMARYS post-hoc analysis.

Eur J Endocrinol 2018 Dec 1. Epub 2018 Dec 1.

P Caron, Department of Endocrinology and Metabolic Diseases, Centre Hospitalier Universitaire Larrey, Toulouse, France.

Objective Pituitary adenoma MRI T2 signal intensity associates with tumor characteristics including responsiveness to somatostatin analogs (SSAs). These analyses determined whether baseline T2 signal intensity predicts response to primary medical treatment with long-acting SSA. Design Post-hoc analyses of the prospective multicenter, open-label, single-arm PRIMARYS study in which patients with treatment-naïve GH-secreting pituitary macroadenomas received fixed-dose lanreotide autogel (120mg) every 4-weeks for 48-weeks. Read More

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http://dx.doi.org/10.1530/EJE-18-0254DOI Listing
December 2018
2 Reads

GLUT3 expression in cystic change induced by hypoxia in pituitary adenomas.

Endocr Connect 2018 Dec 1. Epub 2018 Dec 1.

S Wang, Neurosurgery, Fuzhou General Hospital, Fuzhou, China., Fuzhou, China.

Tumor cells require large amounts of energy to sustain growth. Through the mediated transport of glucose transporters, the uptake and utilization of glucose by tumor cells are significantly enhanced in the hypoxic microenvironment. Pituitary adenomas are benign tumors with high energy metabolisms. Read More

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https://ec.bioscientifica.com/view/journals/ec/aop/ec-18-044
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http://dx.doi.org/10.1530/EC-18-0444DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311462PMC
December 2018
14 Reads

A small 3D-printing model of macroadenomas for endoscopic endonasal surgery.

Pituitary 2019 Feb;22(1):46-53

Department of Neurosurgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, Hubei, China.

Purpose: This paper examines the application of 3D printing technology in the endoscopic endonasal approach for the treatment of macroadenomas.

Methods: We have retrospectively analysed 20 patients who diagnosed with macroadenoma underwent endoscopic transsphenoidal surgery in Wuhan Union hospital from January 2017 to May 2017. Among the 20 patients, 10 patients received the service of 3D printing technology preoperatively. Read More

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http://link.springer.com/10.1007/s11102-018-0927-x
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http://dx.doi.org/10.1007/s11102-018-0927-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373287PMC
February 2019
14 Reads

Predicting response to somatostatin analogues in acromegaly: machine learning-based high-dimensional quantitative texture analysis on T2-weighted MRI.

Eur Radiol 2018 Nov 30. Epub 2018 Nov 30.

Department of Radiology, Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa, Istanbul, Turkey.

Objective: To investigate the value of machine learning (ML)-based high-dimensional quantitative texture analysis (qTA) on T2-weighted magnetic resonance imaging (MRI) in predicting response to somatostatin analogues (SA) in acromegaly patients with growth hormone (GH)-secreting pituitary macroadenoma, and to compare the qTA with quantitative and qualitative T2-weighted relative signal intensity (rSI) and immunohistochemical evaluation.

Methods: Forty-seven patients (24 responsive; 23 resistant patients to SA) were eligible for this retrospective study. Coronal T2-weighted images were used for qTA and rSI evaluation. Read More

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http://dx.doi.org/10.1007/s00330-018-5876-2DOI Listing
November 2018
7 Reads

Endocrine function and gland volume after endoscopic transsphenoidal surgery for nonfunctional pituitary macroadenomas.

J Neurosurg 2018 Nov 1:1-10. Epub 2018 Nov 1.

5Pituitary and Neuroendocrine Center, Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

OBJECTIVELoss of pituitary function due to nonfunctional pituitary adenoma (NFPA) may be due to compression of the pituitary gland. It has been proposed that the size of the gland and relative perioperative gland expansion may relate to recovery of pituitary function, but the extent of this is unclear. This study aims to assess temporal changes in hormonal function after transsphenoidal resection of NFPA and the relationship between gland reexpansion and endocrine recovery. Read More

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http://dx.doi.org/10.3171/2018.5.JNS181054DOI Listing
November 2018
2 Reads

Long-term outcome of trans-sphenoidal surgery for Cushing's disease in Indian patients.

Acta Neurochir (Wien) 2019 Jan 21;161(1):119-127. Epub 2018 Nov 21.

Departments of Endocrinology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India.

Background: The results of trans-sphenoidal surgery (TSS) in Cushing's disease (CD) vary widely depending upon patient characteristics as well as surgical experience. Patients in India are often referred late to referral centers. We studied the rates of remission and endocrine deficiencies after TSS in patients with CD presenting to a referral hospital in India. Read More

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http://dx.doi.org/10.1007/s00701-018-3736-0DOI Listing
January 2019
16 Reads

A machine learning approach to predict early outcomes after pituitary adenoma surgery.

Neurosurg Focus 2018 Nov;45(5):E8

Departments of1Neurosurgery.

OBJECTIVEPituitary adenomas occur in a heterogeneous patient population with diverse perioperative risk factors, endocrinopathies, and other tumor-related comorbidities. This heterogeneity makes predicting postoperative outcomes challenging when using traditional scoring systems. Modern machine learning algorithms can automatically identify the most predictive risk factors and learn complex risk-factor interactions using training data to build a robust predictive model that can generalize to new patient cohorts. Read More

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http://dx.doi.org/10.3171/2018.8.FOCUS18268DOI Listing
November 2018
14 Reads

Safety and Outcome of Transsphenoidal Pituitary Adenoma Resection in Elderly Patients.

World Neurosurg 2019 Feb 14;122:e1252-e1258. Epub 2018 Nov 14.

Department of Neurosurgery, Clinical Neurosciences Center, University of Utah, Salt Lake City, Utah, USA. Electronic address:

Objective: Pituitary adenomas account for 10%-20% of intracranial brain tumors but have greater incidence in elderly patients. We assessed microsurgical treatment for pituitary adenomas in this population.

Methods: A retrospective cohort of patients ≥60 years of age was identified. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18788750183257
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http://dx.doi.org/10.1016/j.wneu.2018.11.024DOI Listing
February 2019
15 Reads

DNA Methylation of Tumor Suppressor Genes in Pituitary Neuroendocrine Tumors.

J Clin Endocrinol Metab 2019 Apr;104(4):1272-1282

Endocrinology Department, Hospital General Universitario de Alicante-ISABIAL, Miguel Hernández University, CIBERER, Alicante, Spain.

Context: Epigenetic alterations may play a role in the development and behavior of pituitary neuroendocrine tumors (PitNETs).

Objective: To evaluate the effect of methylation of tumor suppressor genes (TSGs) on their gene expression and on the behavior of PitNETs.

Material And Methods: We used methylation-specific multiplex ligation-dependent probe amplification and quantitative real-time PCR techniques to analyze the DNA-promoter hypermethylation and gene expression of 35 TSGs in 105 PitNETs. Read More

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http://dx.doi.org/10.1210/jc.2018-01856DOI Listing
April 2019
4 Reads

Gene and protein expression of E-cadherin and NCAM markers in non-functioning pituitary adenomas.

Ann Diagn Pathol 2019 Feb 9;38:59-61. Epub 2018 Oct 9.

Postgraduate Program in Pathology, Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), R. Sarmento Leite, 245 - Centro Histórico, 90050-170 Porto Alegre, RS, Brazil; Neuroendocrinology Center, Complexo Hospitalar Santa Casa, Av. Independência, 75 - Independência, Porto Alegre - RS, 90035-072 Porto Alegre, RS, Brazil.

Non-functioning pituitary adenomas (NFPA) are classified as benign tumors of slow growth, but 40% of them present local invasion, a characteristic of behavior still unpredictable with the use of current tumor markers. This work aims to evaluate the tissue markers E-cadherin and NCAM, which act on cell adhesion, in tumor tissue samples of NFPA and its relationship with the degree of local invasiveness. Gene expression of E-cadherin (CDH1) and NCAM (NCAM1) was assessed by real-time PCR and tissue expression by immunohistochemistry. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2018.10.003DOI Listing
February 2019
4 Reads

Retrospective analysis of 52 patients with prolactinomas following endoscopic endonasal transsphenoidal surgery.

Medicine (Baltimore) 2018 Nov;97(45):e13198

Department of Neurosurgery, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi.

Background: Prolactinomas affect patients' quality of life and even endanger lives. The study aimed to investigate the effect of the endoscopic endonasal transsphenoidal approach (EETA) on 52 patients with prolactinomas.

Methods: A total of 52 patients with prolactinomas who had previously undergone EETA in the People's Hospital of Xinjiang Uygur Autonomous Region between January 2013 and December 2017 were retrospectively analyzed. Read More

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http://dx.doi.org/10.1097/MD.0000000000013198DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6250442PMC
November 2018
10 Reads

Clinical and Laboratory Characteristics of Hyperprolactinemia in Children and Adolescents: National Survey.

J Clin Res Pediatr Endocrinol 2018 Nov 5. Epub 2018 Nov 5.

Objective: We aimed to study the characteristics on admission, diagnosis, treatment, and follow-up of hyperprolactinemic cases in a large multicenter study.

Methods: We reviewed 233 hyperprolactinemic patients under 18 years of age who were followed by different centers. The patients were divided as having microadenomas, macroadenomas, drug-induced hyperprolactinemia, and idiopathic hyperprolactinemia. Read More

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http://cms.galenos.com.tr/Uploads/Article_19906/JCRPE-0-0-En
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http://dx.doi.org/10.4274/jcrpe.0206DOI Listing
November 2018
9 Reads

Thyrotropin-secreting pituitary adenomas: a systematic review and meta-analysis of postoperative outcomes and management.

Pituitary 2019 Feb;22(1):79-88

Department of Neurosurgery, University Hospital of Lausanne, Lausanne, Switzerland.

Purpose: TSH-secreting pituitary adenomas are rare pituitary tumors. An efficient treatment is essential to limit the mortality and morbidity in untreated patients. The aim of this study is to summarize the evidence about the postoperative outcomes and management of this rare pathology. Read More

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http://link.springer.com/10.1007/s11102-018-0921-3
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http://dx.doi.org/10.1007/s11102-018-0921-3DOI Listing
February 2019
12 Reads
2.222 Impact Factor

The importance of the electrophysiological tests in the early diagnosis of ganglion cells and/or optic nerve dysfunction coexisting with pituitary adenoma: an overview.

Doc Ophthalmol 2018 12 29;137(3):193-202. Epub 2018 Oct 29.

II Department of Ophthalmology, Pomeranian Medical University, Powstańców Wlkp. Street, 72, 70-111, Szczecin, Poland.

Background And Methods: Based on the available literature, it is suggested, in the clinical evaluation of the chiasmal tumors, that the following electrophysiological tests: visual evoked potentials to pattern-reversal stimulation, multifocal visual evoked potentials (mfVEPs), and pattern electroretinogram (PERG) play an important role in the diagnosis of the optic nerve and retinal dysfunction in the course of pituitary tumors.

Results: Macroadenomas and also microadenomas may cause dysfunction of retinal ganglion cells (RGCs) and their axons, even in the absence of changes in the routine ophthalmological examination, retinal sensitivity in standard automated perimetry, and retinal nerve fiber layer thickness in optical coherent tomography. The most frequently observed changes in electrophysiological tests were as follows: in PVEPs-the crossed/uncrossed asymmetry distribution, altered waveform, increase in P100-wave peak time, and/or reduction in amplitude; in mfVEPs-the peak time prolongation and/or amplitude reduction in C1-wave; in PERG-the reduction in N95-wave amplitude and decreased N95:P50 amplitude ratio. Read More

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http://link.springer.com/10.1007/s10633-018-9659-5
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http://dx.doi.org/10.1007/s10633-018-9659-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6244962PMC
December 2018
9 Reads

Hyperprolactinemia / Prolactinomas in the post-menopausal period:

challenges in diagnosis and management

.

Neuroendocrinology 2018 Oct 22. Epub 2018 Oct 22.


Hyperprolactinemia is not a common finding in post-menopausal women. Prolactinomas detected after menopause are usually macroadenomas. Due to atypical clinical features they may remain un-recognized for a long period of time. Read More

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http://dx.doi.org/10.1159/000494725DOI Listing
October 2018
2 Reads

Comparison of Endoscopic Versus Microsurgical Resection of Pituitary Adenomas with Parasellar Extension and Evaluation of the Predictive Value of a Simple 4-Quadrant Radiologic Classification.

World Neurosurg 2019 Jan 9;121:e769-e774. Epub 2018 Oct 9.

Department of Neurosurgery, Università degli Studi "G. D'Annunzio", Pescara, Italy.

Background: The amount of parasellar extension is a known limitation for gross total resection (GTR) of pituitary adenomas. Endoscopic technique seems to improve resection of adenomas extending laterally. Knosp classification is used to evaluate the extent of parasellar invasion: increasing Knosp grades correspond with lower rates of GTR. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.09.215DOI Listing
January 2019
3 Reads

The 3PAs: An Update on the Association of Pheochromocytomas, Paragangliomas, and Pituitary Tumors.

Horm Metab Res 2018 Oct 1. Epub 2018 Oct 1.

Section on Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, USA.

Pituitary adenomas (PA) and pheochromocytomas/paragangliomas (PHEO/PGL) are rare tumors. Although they may co-exist by coincidence, there is mounting evidence that genes predisposing in PHEO/PGL development, may play a role in pituitary tumorigenesis. In 2012, we described a GH-secreting PA caused by an mutation in a patient with familial PGLs and found loss of heterozygosity at the locus in the pituitary tumor, along with increased hypoxia-inducible factor 1α (HIF-1α) levels. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/a-0661-0341
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http://dx.doi.org/10.1055/a-0661-0341DOI Listing
October 2018
9 Reads

Fibrous Pituitary Macroadenomas: Predictive Role of Preoperative Radiologic Investigations for Proper Surgical Planning in a Cohort of 66 Patients.

World Neurosurg 2019 Jan 27;121:e449-e457. Epub 2018 Sep 27.

Department of Neurology and Psychiatry-Neurosurgery Unit, "Sapienza" University of Rome, Rome, Italy.

Objective: The endoscopic technique is in many cases the technique of choice for the removal of pituitary adenomas. Extended endoscopic approaches make it possible to remove lesions with suprasellar and parasellar extension and fibrous consistency. We identify some characteristics that might point to the adoption of an expanded approach in the preoperative phase. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18788750183218
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http://dx.doi.org/10.1016/j.wneu.2018.09.137DOI Listing
January 2019
14 Reads

Directional Regulation of Extrasellar Extension by Sellar Dura Integrity and Intrasphenoidal Septation In Pituitary Adenomas.

World Neurosurg 2019 Feb 26;122:e130-e138. Epub 2018 Sep 26.

Department of Neurosurgery, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan.

Objective: Pituitary macroadenomas extend into the extrasellar space, such as the sphenoid sinus, cavernous sinuses, and suprasellar region. However, factors that regulate the direction of their extensions into the surrounding anatomical structures remain unknown.

Methods: This retrospective study included 162 patients who were treated for pituitary adenomas that had maximum diameters greater than 20 mm. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.09.127DOI Listing
February 2019
3 Reads

Recent advances in understanding corticotroph pituitary tumor initiation and progression.

F1000Res 2018 29;7. Epub 2018 Aug 29.

Max Planck Institute of Psychiatry, Clinical Neuroendocrinology Group, Munich, Germany.

Cushing's disease is the most frequent form of hypercortisolism and is caused by hypophyseal corticotroph adenomas secreting excessive amounts of adrenocorticotropic hormone. Most of the tumors develop sporadically and only a limited number of corticotroph adenomas have been found to be associated with different neuroendocrine syndromes or with familial isolated pituitary adenomas. The pathogenic mechanisms of corticotroph adenomas are largely unknown, but the discovered aberrant chaperoning activity of heat shock protein 90 on the one hand and the presence of ubiquitin-specific protease 8 mutations on the other hand partially explained the causes of their development. Read More

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http://dx.doi.org/10.12688/f1000research.14789.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6117851PMC
August 2018
4 Reads

Developing an optimal follow-up strategy based on the natural history of nonfunctioning pituitary adenomas.

J Neurosurg 2018 Sep 1:1-7. Epub 2018 Sep 1.

1Department of Internal Medicine.

OBJECTIVEThe natural history and proper algorithm for follow-up testing of nonfunctioning pituitary adenomas (PAs) are not well known, despite their relatively high prevalence. The aim of this study was to suggest the optimal follow-up algorithm for nonfunctioning PAs based on their natural history.METHODSThe authors followed up 197 patients with nonfunctioning PAs that had not been treated (including surgery and radiation therapy) at the time of detection, in a single center, between March 2000 and February 2017. Read More

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http://dx.doi.org/10.3171/2018.4.JNS172148DOI Listing
September 2018
8 Reads
3.740 Impact Factor

[Optical coherence tomography as a predictor of visual recovery in patients with pituitary macroadenomas].

Surg Neurol Int 2018 13;9(Suppl 3):S57-S65. Epub 2018 Aug 13.

Servicio de Neurocirugía, Hospital Italiano de Buenos Aires, Buenos Aires.

Background: With pituitary macroadenomas, there is a high incidence of visual loss from optic pathway compression. Surgical removal of the tumor usually prevents progression and allows visual recovery. Our objective was to evaluate if optical coherence tomography (OCT) predicts visual outcomes after surgical decompression. Read More

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http://dx.doi.org/10.4103/sni.sni_463_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6108170PMC
August 2018
3 Reads

Clinical assessment of patients with acromegaly.

J Res Med Sci 2018 26;23:61. Epub 2018 Jul 26.

Department of Internal Medicine, Duzce University Medicine Faculty, Duzce, Turkey.

Background: In this study, we aimed to retrospectively evaluate treatment outcomes and treatment methods in acromegaly patients.

Materials And Methods: The study included 65 acromegaly patients followed in Sakarya University Faculty of Medicine Department of Endocrinology in Turkey between 2004 and 2013. Clinical, biochemical, and radiological data were obtained retrospectively from the medical files of the patients. Read More

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http://dx.doi.org/10.4103/jrms.JRMS_139_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6091129PMC
July 2018
4 Reads

Magnetic resonance spectroscopy may serve as a presurgical predictor of somatostatin analog therapy response in patients with growth hormone-secreting pituitary macroadenomas.

J Endocrinol Invest 2018 Aug 31. Epub 2018 Aug 31.

Multidisciplinary Center for Pituitary Adenomas of Chongqing, Chongqing, 400037, China.

Purpose: Somatostatin analogs (SSAs) are considered one of the most effective medical treatments for patients with growth hormone-secreting pituitary adenomas (GH-PAs). The postoperative electron microscopy (EM) pathological subtype and SSTR2 expression in the tumor are the most established predictors of patient response to SSA therapy. The aim of this study was to evaluate how will magnetic resonance spectroscopy (MRS) measurements before surgery predict the EM pathological subtypes and SSTR2 expression of tumors, and thereby serve as an indicator for the therapeutic sensitivity to SSAs of patients with GH-PAs. Read More

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http://dx.doi.org/10.1007/s40618-018-0939-4DOI Listing
August 2018
2 Reads

Pediatric pituitary adenomas in Northeast Mexico. A follow-up study.

Endocrine 2018 11 31;62(2):361-370. Epub 2018 Aug 31.

Karolinska Institute, Department Oncology-Pathology, Stockholm, Sweden.

Purpose: To review incidence, treatment and outcome of pediatric pituitary adenomas (PAs).

Methods: A follow-up study patients with the age of ≤19 years old who were treated from 1995 to 2015 in Mexico.

Results: Out of 1244 diagnosed PA, 43 patients were children (35 females, 8 males) with a mean age of 17. Read More

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http://dx.doi.org/10.1007/s12020-018-1687-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6208845PMC
November 2018
25 Reads
3.530 Impact Factor

A case of a co-secreting TSH and growth hormone pituitary adenoma presenting with a thyroid nodule.

Endocrinol Diabetes Metab Case Rep 2018 23;2018. Epub 2018 Aug 23.

Department of Endocrinology, Diabetes, and Metabolism, University of Kentucky, Lexington, Kentucky, USA.

Co-secreting TSH and growth hormone pituitary adenomas are rare. We present a case of a 55-year-old woman who presented with symptoms of neck fullness. Ultrasound revealed multiple thyroid nodules and examination revealed several clinical features of acromegaly. Read More

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https://edm.bioscientifica.com/view/journals/edm/2018/1/EDM1
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http://dx.doi.org/10.1530/EDM-18-0067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109210PMC
August 2018
11 Reads

Clinical and Radiographic Characteristics Related to Hyperprolactinemia in Nonfunctioning Pituitary Adenomas.

World Neurosurg 2018 Nov 23;119:e1035-e1040. Epub 2018 Aug 23.

Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea; Pituitary Center, Seoul National University College of Medicine, Seoul, Korea.

Objective: Hyperprolactinemia in patients with nonfunctioning pituitary adenomas (NFPAs) has been explained by the stalk compression of large pituitary adenomas. However, not all large NFPAs are associated with high serum prolactin levels. We aimed to elucidate and compare clinical, hormonal, and radiographic characteristics of NFPAs with and without hyperprolactinemia. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.08.068DOI Listing
November 2018
19 Reads
2.420 Impact Factor

Relationship between postoperative volume of macroadenomas and clinical outcome after endoscopic trans-sphenoidal resection.

Neuroradiol J 2018 Dec 9;31(6):565-571. Epub 2018 Aug 9.

1 Department of Radiology, University of North Carolina Hospitals, USA.

Purpose: Although symptoms are expected to improve after the resection of pituitary macroadenomas, tumor resection volume does not always correlate with the patient's symptoms. Our objectives were to assess the pre and postoperative volumes of pituitary macroadenomas before, immediately after surgery and at follow-up, and to explore possible associations and correlations among these changes and symptoms.

Materials And Methods: We retrospectively reviewed the clinical records and the preoperative and postoperative magnetic resonance imaging studies at 24 hours and at 3, 6 and 9 months follow-up of 146 patients who underwent surgery for pituitary macroadenomas. Read More

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http://dx.doi.org/10.1177/1971400918791699DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6243460PMC
December 2018
16 Reads

The relation of pituitary adenomas invasiveness and the proliferative index measured by immunoexpression of topoisomerase IIα.

Endokrynol Pol 2018 3;69(5):530-535. Epub 2018 Aug 3.

Chair and Department of Endocrinology, Jagiellonian University Medical College, Kopernika 17, 31-501 Kraków, Poland.

Introduction: Cavernous sinus invasion by pituitary adenoma affects surgical procedure radicality and consequently the postoperative course and prognosis in pituitary adenoma treatment. The search for pituitary adenoma aggressive behaviour markers is still a matter of debate.

Material And Methods: This study evaluates the relation of pituitary adenoma invasiveness to the expression of topoisomerase IIα in 72 patients who underwent transsphenoidal pituitary surgery. Read More

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http://dx.doi.org/10.5603/EP.a2018.0050DOI Listing
August 2018
3 Reads

Visual outcome of surgically managed pituitary adenomas followed-up at the Yaoundé Central Hospital.

Br J Neurosurg 2018 Oct 3;32(5):521-527. Epub 2018 Aug 3.

a Higher Institute of Health Sciences , Université des Montagnes , Bangangté , Cameroon.

Introduction: Pituitary adenomas are benign brain tumours arising from the adenohypophysis; representing 10-15% of all intra-cranial tumours. Despite improved management, they are still related to high morbidity. Visual impairment is a common presentation and visual field defects representing 37-96%. Read More

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http://dx.doi.org/10.1080/02688697.2018.1498449DOI Listing
October 2018
4 Reads

Efficacy and safety of long-acting pasireotide in patients with somatostatin-resistant acromegaly: a multicenter study.

Endocrine 2018 11 26;62(2):448-455. Epub 2018 Jul 26.

Tel-Aviv Sourasky Medical Center and Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel.

Introduction: Pasireotide, a multi-somatostatin receptor (SSTR)-ligand with high affinity for SSTR was recently approved for acromegaly treatment.

Patients And Methods: A retrospective multicenter study investigating the efficacy and safety of long-acting (LAR) pasireotide treatment in 35 patients (20 males) with active acromegaly (28 macroadenomas).

Results: Mean baseline insulin-like growth factor-1 (IGF-1) at diagnosis was 3. Read More

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http://dx.doi.org/10.1007/s12020-018-1690-5DOI Listing
November 2018
6 Reads