1,446 results match your criteria Pituitary Macroadenomas


Association of PTP4A3 expression and tumour size in functioning pituitary adenoma: a descriptive study.

J Clin Pathol 2020 Jul 2. Epub 2020 Jul 2.

Instituto de Investigaciones en Ciencias de la Salud (INICSA), Centro de Microscopia Electronica-Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Cordoba, Argentina

Background: PTP4A3 is a subclass of a protein tyrosine phosphatase super family and is expressed in a range of epithelial neoplasms. We evaluated PTP4A3 expression and its association with clinicopathological parameters in different types of functioning pituitary adenomas.

Methods: A total of 34 functioning pituitary adenomas samples were evaluated in this observational study. Read More

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http://dx.doi.org/10.1136/jclinpath-2020-206728DOI Listing

Pituitary Apoplexy: A Comprehensive Review.

Neurol India 2020 May-Jun;68(Supplement):S72-S78

Department of Neurosurgery, Devadoss Hospital, Madurai, Tamil Nadu, India.

Pituitary apoplexy (PA) is a rare, usually vision-threatening and occasionally life-threatening entity. The exact incidence of PA in large series of pituitary adenomas is variable; however, it is more common in macroadenomas and nonfunctioning adenomas though it has been reported rarely in microadenomas. There are several well-known precipitating factors for PA including the use of anticoagulants, surgery, head trauma, pregnancy, etc. Read More

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http://dx.doi.org/10.4103/0028-3886.287669DOI Listing

Pituitary Disease in Mutation-Positive Familial Isolated Pituitary Adenoma (FIPA): A Kindred-Based Overview.

J Clin Med 2020 Jun 26;9(6). Epub 2020 Jun 26.

Department of Endocrinology, Centre Hospitalaire Universitaire de Liège, Liège Université, 4000 Liège, Belgium.

Clinically-relevant pituitary adenomas occur in about 1:1000 of the general population, but only about 5% occur in a known genetic or familial setting. Familial isolated pituitary adenomas (FIPA) are one of the most important inherited settings for pituitary adenomas and the most frequent genetic cause is a germline mutation in the () gene. mutations lead to young-onset macroadenomas that are difficult to treat. Read More

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http://dx.doi.org/10.3390/jcm9062003DOI Listing

Preoperative vascular heterogeneity and aggressiveness assessment of pituitary macroadenoma based on dynamic contrast-enhanced MRI texture analysis.

Eur J Radiol 2020 Jun 13;129:109125. Epub 2020 Jun 13.

Department of Radiology, First Affiliated Hospital of Dalian Medical University, 222 Zhongshan Road, Xigang, Dalian, 116000, China. Electronic address:

Purpose: To assess the vascular heterogeneity and aggressiveness of pituitary macroadenomas (PM) using texture analysis based on Dynamic Contrast-Enhanced MRI (DCE-MRI).

Method: Fifty patients with pathologically confirmed PM, including 32 patients with aggressive PM (aggressive group) and 18 patients with non-aggressive PM (non-aggressive group), were included in this study. The preoperative DCE-MRI and clinical data were collected from all patients. Read More

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http://dx.doi.org/10.1016/j.ejrad.2020.109125DOI Listing

The Chiasmal Compression Index - An Integrative Assessment Tool For Visual Disturbances In Patients With Pituitary Macroadenomas.

World Neurosurg 2020 Jun 17. Epub 2020 Jun 17.

Department of Neurosurgery, Soroka University Medical Center and Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel.

Objective: Visual status is routinely evaluated by neuro-ophthalmological examination and computerized visual fields test in patients with chiasmal compression secondary to pituitary macroadenoma (PMA). Currently, no relevant data exists to accurately quantify the extent of optic apparatus compromise in order to further guide clinical decision making. We aimed to assess for a possible quantitative correlation between optic chiasm geometric properties on MRI and visual field deficits. Read More

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http://dx.doi.org/10.1016/j.wneu.2020.06.086DOI Listing

Differentiation of suprasellar meningiomas from non-functioning pituitary macroadenomas by F-FDG and N-Ammonia PET/CT.

BMC Cancer 2020 Jun 17;20(1):564. Epub 2020 Jun 17.

Department of the Medical Imaging, The First Affiliated Hospital, Sun Yat-sen University, 58# Zhongshan Er Road, Guangzhou, Guangdong Province, 510080, People's Republic of China.

Background: Differentiation of suprasellar meningiomas (SSMs) from non-functioning pituitary macroadenomas (NFPMAs) is useful for clinical management. We investigated the utility of N-ammonia combined with F-FDG positron emission tomography (PET)/computed tomography (CT) in distinguishing SSMs from NFPMAs retrospectively.

Methods: Fourteen NFPMA patients and eleven SSM patients with histopathologic diagnosis were included in this study. Read More

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http://dx.doi.org/10.1186/s12885-020-06852-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7301455PMC

Differential Expression of MicroRNAs in Silent and Functioning Corticotroph Tumors.

J Clin Med 2020 Jun 12;9(6). Epub 2020 Jun 12.

Endocrinology Department, Alicante General University Hospital-ISABIAL, Miguel Hernández University, CIBERER, 03010 Alicante, Spain.

The potential role of miRNAs in the silencing mechanisms of pituitary neuroendocrine tumors (PitNETs) has not been addressed. The aim of the present study was to evaluate the expression levels and the potential associated role of some miRNAs, pathways, and transcription factors in the silencing mechanisms of corticotroph tumors (CTs). Accordingly, the expression of miR-375, miR-383, miR-488, miR-200a and miR-103; of , , , , , , , and were analyzed via qRT-PCR in 23 silent and 24 functioning CTs. Read More

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http://dx.doi.org/10.3390/jcm9061838DOI Listing

Development and clinical validation of a grading system for pituitary adenoma consistency.

J Neurosurg 2020 Jun 5:1-8. Epub 2020 Jun 5.

1Department of Neurological Surgery.

Objective: Pituitary adenoma (PA) consistency, or texture, is an important intraoperative characteristic that may dictate operative dissection techniques and/or instruments used for tumor removal during endoscopic endonasal approaches (EEAs). The impact of PA consistency on surgical outcomes has yet to be elucidated.

Methods: The authors developed an objective 5-point grading scale for PA consistency based on intraoperative characteristics, including ease of tumor debulking, manipulation, and instrument selection, ranging from cystic/hemorrhagic tumors (grade 1) to calcified tumors (grade 5). Read More

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http://dx.doi.org/10.3171/2020.4.JNS193288DOI Listing

Surgical outcomes and multidisciplinary management strategy of Cushing's disease: a single-center experience in China.

Neurosurg Focus 2020 Jun;48(6):E7

1Department of Neurosurgery, and.

Objective: The primary aim of this study was to investigate the value of multidisciplinary team (MDT) management in treating patients with Cushing's disease (CD). The secondary aim was to assess the concordance of bilateral inferior petrosal sinus sampling (BIPSS) lateralization with intraoperative observations.

Methods: The authors recruited 124 consecutive patients (128 procedures) who had undergone endoscopic endonasal resection of adrenocorticotropic hormone-secreting pituitary adenomas from May 2014 to April 2018 and assessed their clinical characteristics, surgical outcomes, and adjuvant therapies. Read More

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http://dx.doi.org/10.3171/2020.3.FOCUS2067DOI Listing
June 2020
2.105 Impact Factor

Does pituitary compression/empty sella syndrome contribute to MRI-negative Cushing's disease? A single-institution experience.

Neurosurg Focus 2020 Jun;48(6):E3

Departments of1Neurologic Surgery.

Objective: Cushing's disease arises from functioning adrenocorticotropic hormone (ACTH)-secreting pituitary adenomas. These tumors can be very small and evade detection by MRI. Empty sella syndrome is a phenomenon by which an arachnoid outpouching of CSF into the sella leads to compression of the pituitary, likely due to intracranial hypertension (a common issue in Cushing's disease), further leading to difficulty in visualizing the pituitary gland that may contribute to difficulty in finding a tumor on MRI, so-called MRI-negative Cushing's disease. Read More

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http://dx.doi.org/10.3171/2020.3.FOCUS2084DOI Listing

Impact of tumor characteristics and pre- and postoperative hormone levels on hormonal remission following endoscopic transsphenoidal surgery in patients with acromegaly.

Neurosurg Focus 2020 Jun;48(6):E10

1Department of Neurosurgery, USC Pituitary Center, Keck School of Medicine of University of Southern California, Los Angeles, California.

Objective: Acromegaly is a disease of acral enlargement and elevated serum levels of insulin-like growth factor-1 (IGF-1) and growth hormone (GH), usually caused by a pituitary adenoma. A lack of consensus on factors that reliably predict outcomes in acromegalic patients following endoscopic endonasal transsphenoidal surgery (EETS) warrants additional investigation.

Methods: The authors identified 52 patients with acromegaly who underwent an endoscopic endonasal approach (EEA) for resection of a GH-secreting pituitary adenoma. Read More

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http://dx.doi.org/10.3171/2020.3.FOCUS2080DOI Listing

Predictive model of surgical remission in acromegaly: age, presurgical GH levels and Knosp grade as the best predictors of surgical remission.

J Endocrinol Invest 2020 May 21. Epub 2020 May 21.

Neuroendocrinology Unit, Department of Neurosurgery, Hospital Universitario Ramón y Cajal, Madrid, Spain.

Purpose: To identify presurgical clinical, hormonal and radiological variables associated with surgical remission in acromegaly and develop a predictive model for surgical remission.

Methods: Ambispective study of acromegaly surgical patients followed in two Spanish tertiary hospitals. Patients operated by the same neurosurgeon by endonasal endoscopic transsphenoidal approach (n = 49) were included to develop the predictive model, and patients operated by other neurosurgeons (n = 37) were used for external validation of the predictive model. Read More

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http://dx.doi.org/10.1007/s40618-020-01296-4DOI Listing

Quality of care evaluation in non-functioning pituitary adenoma with chiasm compression: visual outcomes and timing of intervention clinical recommendations based on a systematic literature review and cohort study.

Pituitary 2020 Aug;23(4):417-429

Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands.

Purpose: Surgery in patients with non-functioning pituitary macroadenomas (NFMA) is effective in ameliorating visual function. The urgency for decompression, and preferred timing of surgery related to the preoperative severity of dysfunction is unknown.

Methods: Systematic review for evidence to provide clinical guidance for timing of surgical decompression of the optic chiasm, and a cohort study of 30 NFMA patients, in whom mean deviation (MD), and severity of visual dysfunction was assessed. Read More

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http://dx.doi.org/10.1007/s11102-020-01044-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316692PMC

Utility and pitfalls of high field 3 tesla intraoperative MRI in neurosurgery: A single centre experience of 100 cases.

Neurol India 2020 Mar-Apr;68(2):413-418

Department of Radiodiagnosis, Yashoda Superspeciality Hospital, Secunderabad, Telangana, India.

Objective: In India, few centers are using 1.5 Tesla intraoperative MRI systems. We are using a 3 Tesla iMRI system. Read More

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http://dx.doi.org/10.4103/0028-3886.284359DOI Listing

Efficacy of endoscopic transsphenoidal surgery for cushing's disease: Case series and review of the literature.

Neurol India 2020 Mar-Apr;68(2):403-406

Department of Neurosurgery, Nara Medical University, Kashihara, Japan.

Background: This study was performed to examine the efficacy of endoscopic transsphenoidal surgery (ETS) for Cushing's disease at a single institute and to review past reports.

Material And Methods: We studied eight consecutive patients who underwent ETS for Cushing's disease. The radiological evaluation comprised a detailed examination of preoperative magnetic resonance images (MRIs), including inferior petrosal sinus sampling, for cases with normal renal function. Read More

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http://dx.doi.org/10.4103/0028-3886.284363DOI Listing

Clinical features and therapeutic outcomes of patients with acromegaly in Saudi Arabia: a retrospective analysis.

Hormones (Athens) 2020 May 9. Epub 2020 May 9.

Department of Medicine, King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia.

Background: Acromegaly is a rare disease resulting in clinical sequelae with significant morbidity and mortality due to the central tumor mass effect and prolonged growth hormone (GH) hypersecretion.

Objectives: The goal is to describe the epidemiology, clinical features, presence of comorbidities, and treatment outcomes of acromegaly in Saudi Arabia.

Methods: Data was collected through a retrospective review of the charts of all patients diagnosed with acromegaly from nine major hospitals in Saudi Arabia over a period of more than 25 years. Read More

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http://dx.doi.org/10.1007/s42000-020-00191-0DOI Listing

Surgical management of growth hormone-secreting pituitary adenomas: A retrospective analysis of 33 patients.

Medicine (Baltimore) 2020 May;99(19):e19855

Neurosurgery Department.

The endoscopic endonasal transsphenoidal approach (EETA) is the primary treatment for growth hormone (GH) adenoma. This study aimed to investigate the outcomes of EETA in 33 patients with GH-secreting pituitary adenoma (PA).Thirty-three patients who underwent EETA in Eighth People's Hospital of Shenzhen between January 2013 and December 2017 were included in the comprehensive analysis. Read More

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http://dx.doi.org/10.1097/MD.0000000000019855DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220440PMC

Suprasellar pituitary adenomas: a 10-year experience in a single tertiary medical center and a literature review.

Pituitary 2020 Aug;23(4):367-380

Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, 100730, China.

Background: Suprasellar pituitary adenomas (SPAs) are a special type of pituitary adenoma. Although dozens of SPA cases have been reported, the exact definition and the characteristics of SPA have not been exhaustively discussed before.

Methods: In a retrospective electronic medical records review, 13 patients with SPA were identified in our hospital between January 2010 and December 2019. Read More

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http://dx.doi.org/10.1007/s11102-020-01043-1DOI Listing
August 2020
2.222 Impact Factor

Comparative analysis of rhinologic outcomes in Cushing disease and non-functioning pituitary adenoma in patients submitted to endoscopic endonasal transsphenoidal surgery.

Eur Arch Otorhinolaryngol 2020 Apr 28. Epub 2020 Apr 28.

Department of Otorhinolaryngology and Head and Neck Surgery, Faculty of Medical Sciences, State University of Campinas, Tessália Viera de Camargo, 126, Campinas, São Paulo, 13083-887, Brazil.

Purpose: Adrenocorticotropic hormone (ACTH) secreted by pituitary tumors lead to changes in nasal cavity anatomy and physiology. As a consequence of hormonal alteration, there is an abnormal soft tissue and an increased capillary fragility, inducting to a thinner mucosa that acts in the healing process. We compared post-operative nasal alterations in patients with Cushing's disease versus patients with non-functioning macroadenomas who underwent endoscopic endonasal transsphenoidal surgery. Read More

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http://dx.doi.org/10.1007/s00405-020-05974-0DOI Listing
April 2020
1.608 Impact Factor

Increased mRNA and miR-17-5p Expression Is Correlated to Invasiveness and Proliferation of Pituitary Neuroendocrine Tumours.

Diagnostics (Basel) 2020 Apr 16;10(4). Epub 2020 Apr 16.

Department of Endocrinology & Nutrition, Hospital General Universitario de Alicante, Miguel Hernández University, 03010 Alicante, Spain.

miR-17-5p and have been described as deregulated in cancer, but they have scarcely been studied in pituitary neuroendocrine tumours (PitNETs). This study evaluates the relationship of and miR-17-5p with the invasiveness and proliferation of PitNETs. In this cross-sectional descriptive study, we evaluated the expression of , , and miR-17-5p by quantitative real time PCR analysis in 60 PitNETs: 29 gonadotroph (GT), 15 functioning somatotroph (ST), and 16 corticotroph (CT) tumours, of which 8 were silent (sCT). Read More

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http://dx.doi.org/10.3390/diagnostics10040227DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235816PMC

[Clinical and genetic studies of a three-member familial isolated pituitary adenoma with homogeneous prolactinomas].

Medicina (B Aires) 2020 ;80(2):181-184

Department of Endocrinology, Centre Hospitalier Universitaire de Liège, University of Liege, Liege, Belgium. E-mail:

Most pituitary adenomas are sporadic, but 3-5% can occur in a family and hereditary context. This is the case of multiple endocrine neoplasia type 1 (MEN1), Carney complex (CNC) and familial isolated pituitary adenomas (FIPA). FIPA is an infrequent condition that occurs in a family context, not associated with MEN type1 or CNC. Read More

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Clinical study of endoscopic treatment of a sellar pituitary adenomas with sellar diaphragm defect.

BMC Neurol 2020 Apr 11;20(1):129. Epub 2020 Apr 11.

The First Affiliated Hospital of China Medical University, No.155, North Nanjing Street, Heping District, Shenyang, 110001, Liaoning, People's Republic of China.

Background: Invasive growth of pituitary macroadenomas to the suprasellar region occurs commonly. Pituitary adenomas show varying growth patterns when the sellar diaphragm is absent, and they are often confused with other common tumors in the sellar region. This article explores the clinical features of suprasellar pituitary adenomas with defects of the sellar diaphragm (SPADSD) and evaluates the efficacy of the endoscopic endonasal approach (EEA) for treatment of such tumors. Read More

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http://dx.doi.org/10.1186/s12883-020-01690-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7149879PMC

Presenting Features in 269 Patients With Clinically Nonfunctioning Pituitary Adenomas Enrolled in a Prospective Study.

J Endocr Soc 2020 Apr 18;4(4):bvaa021. Epub 2020 Feb 18.

Departments of Neurosurgery, Mount Sinai School of Medicine, New York, New York.

Context: Clinically nonfunctioning pituitary adenomas (CNFPAs) typically remain undetected until mass effect symptoms develop. However, currently, head imaging is performed commonly for many other indications, which may increase incidental discovery of CNFPAs. Since current presentation and outcome data are based on older, retrospective series, a prospective characterization of a contemporary CNFPA cohort was needed. Read More

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http://dx.doi.org/10.1210/jendso/bvaa021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7101088PMC

Pituitary adenomas in the setting of multiple endocrine neoplasia type 1: a single-institution experience.

J Neurosurg 2020 Apr 3:1-7. Epub 2020 Apr 3.

Departments of1Neurological Surgery.

Objective: Multiple endocrine neoplasia type 1 (MEN1) is a rare, autosomal-dominant tumor disorder characterized by the development of pituitary tumors and other endocrine neoplasms. Diagnosis is made clinically based on the development of 2 or more canonical lesions (parathyroid gland, anterior pituitary, and enteropancreatic tumors) or in family members of a patient with a clinical diagnosis of MEN1 and the occurrence of one of the MEN1-associated tumors. The goal of this study was to characterize pituitary tumors arising in the setting of MEN1 at a single institution. Read More

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http://dx.doi.org/10.3171/2020.1.JNS193538DOI Listing

Prevalence and characteristics of sellar masses in the city of Al Ain, United Arab Emirates: 2010 to 2016.

Ann Saudi Med 2020 Mar-Apr;40(2):105-112. Epub 2020 Apr 2.

From the Department of Medicine, United Arab Emirates University, Al Ain, Abu Dhabi, United Arab Emirates.

Background: The prevalence of sellar masses (SMs) is reported in Europe and North America but only limited data are available from the Middle East and North Africa (MENA) region.

Objectives: Assess the prevalence and characteristics of SMs in Al Ain city, United Arab Emirates.

Design: Retrospective, descriptive multicenter study. Read More

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http://dx.doi.org/10.5144/0256-4947.2020.105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7118230PMC

Clinical Characteristics and Treatment Outcomes in Endogenous Cushing's Syndrome: A 15-Year Experience from Thailand.

Case Rep Endocrinol 2020 12;2020:2946868. Epub 2020 Mar 12.

Division of Endocrinology and Metabolism, Department of Medicine, and Hormonal and Metabolic Research Unit, Excellence Center in Diabetes, Hormone and Metabolism, Faculty of Medicine, Chulalongkorn University, and King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Patumwan, Bangkok 10330, Thailand.

The most common subtype of endogenous Cushing's syndrome (CS) is Cushing's disease (CD), with higher proportions of adrenal CS reported from Asia, compared to other continents. However, little was known about CS in this territory. This study was to investigate the distribution, clinical characteristics, and treatment outcomes of CS in a single tertiary hospital in Thailand. Read More

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http://dx.doi.org/10.1155/2020/2946868DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7091524PMC

Delayed Hyponatremia Following Surgery for Pituitary Adenomas: An Under-recognized Complication.

Neurol India 2020 Mar-Apr;68(2):340-345

Department of Neurological Sciences, Christian Medical College, Vellore, Tamil Nadu, India.

Background: Delayed hyponatremia is a serious complication seen after pituitary surgery. We document the incidence, presentation, outcome and risk factors for this condition.

Materials And Methods: This was a retrospective study involving 222 patients operated for nonfunctioning pituitary macroadenomas between 2007-2016. Read More

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http://dx.doi.org/10.4103/0028-3886.280637DOI Listing

Quantitative pharmacokinetic analysis of high-temporal-resolution dynamic contrast-enhanced MRI to differentiate the normal-appearing pituitary gland from pituitary macroadenoma.

Jpn J Radiol 2020 Jul 11;38(7):649-657. Epub 2020 Mar 11.

Department of Radiology, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima, 890-8544, Japan.

Purpose: To evaluate the usefulness of high-temporal-resolution dynamic contrast-enhanced (DCE) MRI and quantitative pharmacokinetic analysis to differentiate the normal-appearing pituitary gland from a pituitary macroadenoma.

Materials And Methods: Twenty-seven patients with macroadenomas underwent preoperative DCE-MRI with a temporal resolution of 5 s using compressed sensing to obtain pharmacokinetic parameters. Two independent observers localized the normal-appearing pituitary gland on post-contrast T1-weighted images before and after referring to the corresponding K maps. Read More

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http://dx.doi.org/10.1007/s11604-020-00942-4DOI Listing

Endoscopic Endo-nasal Trans-Sphenoidal Approach for Pituitary Adenomas: A Prospective Study.

Indian J Otolaryngol Head Neck Surg 2020 Mar 19;72(1):36-43. Epub 2019 Aug 19.

Department of ENT and Head Neck Surgery, Government Medical College Silvassa, Shri Vinoba Bhave Civil Hospital, Silvassa, Dadra and Nagar Haveli India.

The surgical approach for hypophysectomy has undergone sweeping revolution in the past three decades. With the advent of endoscopes, better instrumentation, better illumination and viewing cameras, endoscopic endo-nasal trans-sphenoidal approach to sella has now largely become the norm. The aim of this study is to present our experience, analysing the surgical outcomes of this approach in patients with pituitary adenoma, pertaining to entirety of tumor removal, alleviation of symptoms and rate of complications. Read More

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http://dx.doi.org/10.1007/s12070-019-01725-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7040117PMC

Editorial for "Texture Analysis of High b-value Diffusion-Weighted Imaging for Evaluating Consistency of Pituitary Macroadenomas".

J Magn Reson Imaging 2020 May 10;51(5):1514-1515. Epub 2020 Mar 10.

Department of Radiology, Stony Brook University, Stony Brook, New York, USA.

Level Of Evidence: 5 TECHNICAL EFFICACY: Stage 3 J. Magn. Reson. Read More

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http://dx.doi.org/10.1002/jmri.27130DOI Listing

Suprasellar extension independently predicts preoperative pituitary hormone deficiencies in patients with nonfunctioning pituitary macroadenomas: a single-center experience.

Hormones (Athens) 2020 Jun 2;19(2):245-251. Epub 2020 Mar 2.

Department of Endocrinology Diabetes and Metabolism, Evangelismos Hospital, 10676, Athens, Greece.

Purpose: Nonfunctioning pituitary adenomas (NFPAs) are among the commonest benign tumors of the pituitary. Hypopituitarism is frequently present at the time of diagnosis, and this has been attributed to stalk portal vessel compression and/or destruction of normal anterior pituitary cells. The aim of our study was to examine possible factors at diagnosis associated with the presence of hypopituitarism. Read More

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http://dx.doi.org/10.1007/s42000-020-00183-0DOI Listing

Analysis of 7-tesla diffusion-weighted imaging in the prediction of pituitary macroadenoma consistency.

J Neurosurg 2020 Feb 28:1-9. Epub 2020 Feb 28.

1Translational and Molecular Imaging Institute; and.

Objective: Endoscopic surgery is an effective treatment strategy for pituitary adenomas; however, intrinsic tumor properties such as tumor consistency can challenge or preclude gross-total resection. Preoperative characterization of tumor consistency may help to guide the surgical approach and to predict the extent of resection that is possible. Advanced radiological modalities such as 7T diffusion-weighted imaging (DWI) may be useful in probing biological tissue properties of pituitary adenomas. Read More

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http://dx.doi.org/10.3171/2019.12.JNS192940DOI Listing
February 2020

HEREDITARY ENDOCRINE TUMOURS: CURRENT STATE-OF-THE-ART AND RESEARCH OPPORTUNITIES: The roles of AIP and GPR101 in familial isolated pituitary adenomas (FIPA).

Endocr Relat Cancer 2020 Aug;27(8):T77-T86

Department of Endocrinology, Centre Hospitalier Universitaire de Liège, University of Liège, Liège, Belgium.

Familial isolated pituitary adenoma (FIPA) is one of the most frequent conditions associated with an inherited presentation of pituitary tumors. FIPA can present with pituitary adenomas of any secretory/non-secretory type. Mutations in the gene for the aryl-hydrocarbon receptor interacting protein (AIP) have been identified in approximately 20% of FIPA families and are the most frequent cause (29%) of pituitary gigantism. Read More

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http://dx.doi.org/10.1530/ERC-20-0015DOI Listing

Letter to the Editor. Structural retinotopic analysis at 7-Tesla MRI in pituitary macroadenomas.

J Neurosurg 2020 Feb 14:1-3. Epub 2020 Feb 14.

5State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.

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http://dx.doi.org/10.3171/2019.11.JNS193149DOI Listing
February 2020

Long-term outcomes after endoscopic endonasal surgery for nonfunctioning pituitary macroadenomas.

J Neurosurg 2020 Jan 31:1-12. Epub 2020 Jan 31.

Departments of1Neurosurgery.

Objective: Nonfunctioning pituitary adenomas are benign, slow-growing tumors. After gross-total resection (GTR) or subtotal resection (STR), tumors can recur or progress and may ultimately require additional intervention. A greater understanding of long-term recurrence and progression rates following complete or partial resection and the need for further intervention will help clinicians provide meaningful counsel for their patients and assist data-driven decision-making. Read More

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http://dx.doi.org/10.3171/2019.11.JNS192457DOI Listing
January 2020

Significant Benefits of AIP Testing and Clinical Screening in Familial Isolated and Young-onset Pituitary Tumors.

J Clin Endocrinol Metab 2020 Jun;105(6)

Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.

Context: Germline mutations in the aryl hydrocarbon receptor-interacting protein (AIP) gene are responsible for a subset of familial isolated pituitary adenoma (FIPA) cases and sporadic pituitary neuroendocrine tumors (PitNETs).

Objective: To compare prospectively diagnosed AIP mutation-positive (AIPmut) PitNET patients with clinically presenting patients and to compare the clinical characteristics of AIPmut and AIPneg PitNET patients.

Design: 12-year prospective, observational study. Read More

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http://dx.doi.org/10.1210/clinem/dgaa040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7137887PMC

Endoscopic subperichondrial transseptal transsphenoidal approach is safe and efficient for non-extended pituitary surgery.

Eur Arch Otorhinolaryngol 2020 Apr 20;277(4):1079-1087. Epub 2020 Jan 20.

Department of Neurosurgery, University Hospital of Montpellier, Montpellier, France.

Purpose: To report the results of a series of patients undergoing the endoscopic subperichondrial transseptal (STRAS) approach for pituitary surgery and to evaluate the efficiency and the safety of this approach.

Methods: This is a single-centre retrospective study including all patients undergoing pituitary lesion resection through the STRAS approach from January 2002 to December 2017 by a multidisciplinary surgical team (ENT and neurosurgeon). Demographic data, tumour type, complication rate and pre- and post-operative visual, endocrine and tumour status were retrospectively analysed. Read More

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http://dx.doi.org/10.1007/s00405-020-05790-6DOI Listing

Oral disorders related to acromegaly.

Pan Afr Med J 2019 16;34:96. Epub 2019 Oct 16.

Oral surgery department, Faculty of Dentistry of Rabat, Mohammed V University, Morocco.

Acromegaly is a rare disease caused due to hyper secretion of growth hormone. Most of the cases of acromegaly are caused by pituitary adenoma which can be microadenoma or macroadenomas. This condition has a tendency toward overgrowth of the mandible, maxillary widening, tooth separation and skeletal malocclusion which compromises the aesthetics of an individual. Read More

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http://dx.doi.org/10.11604/pamj.2019.34.96.19873DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6945669PMC
January 2020

Clinical Relevance of Genetic Analysis in Patients With Pituitary Adenomas: A Systematic Review.

Front Endocrinol (Lausanne) 2019 10;10:837. Epub 2019 Dec 10.

Department of Endocrine Oncology, University Medical Center Utrecht, Utrecht, Netherlands.

Pituitary adenomas (PA) are amongst the most prevalent intracranial tumors, causing complications by hormonal overproduction or deficiency and tumor mass effects, with 95% of cases occurring sporadically. Associated germline mutations () and microduplications are increasingly identified, but the clinical consequences in sporadic PA remain unclear. This systematic review evaluates predictors of a genetic cause of sporadic PA and the consequences for treatment outcome. Read More

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http://dx.doi.org/10.3389/fendo.2019.00837DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6914701PMC
December 2019

Cut-off values for sufficient cortisol response to low dose Short Synacthen Test after surgery for non-functioning pituitary adenoma.

Acta Neurochir (Wien) 2020 04 6;162(4):845-852. Epub 2020 Jan 6.

Section of Specialized Endocrinology, Rikshospitalet, Oslo University Hospital, Oslo, Norway.

Objective: The aim was to study the prevalence of secondary adrenal insufficiency before and after surgery for non-functioning pituitary adenomas, as well as determine risk factors for developing secondary adrenal insufficiency. A secondary aim was to determine adequate p-cortisol response to a 1-μg Short Synacthen Test after surgery.

Design: Longitudinal cohort study. Read More

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http://dx.doi.org/10.1007/s00701-019-04068-zDOI Listing

MRI texture analysis in acromegaly and its role in predicting response to somatostatin receptor ligands.

Pituitary 2020 Jun;23(3):212-222

Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, 100 Blossom Street, Suite 140, Boston, MA, 02114, USA.

Purpose: Given the paucity of reliable predictors of tumor recurrence, progression, or response to somatostatin receptor ligand (SRL) therapy in acromegaly, we attempted to determine whether preoperative MR image texture was predictive of these clinical outcomes. We also determined whether image texture could differentiate somatotroph adenomas from non-functioning pituitary adenomas (NFPAs).

Methods: We performed a retrospective study of patients with acromegaly due to a macroadenoma who underwent transsphenoidal surgery at our institution between 2007 and 2015. Read More

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http://dx.doi.org/10.1007/s11102-019-01023-0DOI Listing

Effect of Intraoperative Lumbar Drainage on Gross Total Resection and Cerebrospinal Fluid Leak Rates in Endoscopic Transsphenoidal Surgery of Pituitary Macroadenomas.

World Neurosurg 2020 Mar 25;135:e629-e639. Epub 2019 Dec 25.

Department of Neurosurgery, Xi'an International Medical Center, Xi'an, Shaanxi Province, China; Department of Neurosurgery, Tangdu Hospital, Fourth Military Medical University, Xi'an, Shaanxi Province, China. Electronic address:

Objective: We sought to assess whether controlled, intraoperative lumbar drainage (LD) of cerebrospinal fluid (CSF) could facilitate resection of pituitary macroadenomas and reduce the rate of CSF leak.

Methods: A retrospective cohort study from a prospective database was conducted on 189 patients with pituitary macroadenoma who received endoscopic transsphenoidal surgery between 2013 and 2017. Patients were classified into 2 groups: 119 patients received an intraoperative LD (LD group) and 70 patients underwent routine endoscopic surgery without LD (control group). Read More

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http://dx.doi.org/10.1016/j.wneu.2019.12.100DOI Listing

Obesity is common at diagnosis of childhood pituitary adenoma and may persist following successful treatment.

Clin Endocrinol (Oxf) 2020 Apr 19;92(4):323-330. Epub 2020 Jan 19.

Department of Endocrinology, Alder Hey Children's Hospital, Liverpool, UK.

Objective: There is a paucity of data describing long-term outcomes of paediatric patients with pituitary adenoma. In this report, we describe clinical features, treatment and outcomes of a paediatric cohort.

Design: Retrospective cohort study. Read More

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http://dx.doi.org/10.1111/cen.14146DOI Listing
April 2020
3.457 Impact Factor

Pituicytoma Associated with Acromegaly and Cushing Disease.

World Neurosurg 2020 Apr 24;136:78-82. Epub 2019 Dec 24.

Department of Neurosurgery, FLENI, Buenos Aires, Argentina.

Background: Pituicytoma is a rare neoplasm arising in the sellar region (World Health Organization grade I). Clinically, pituicytomas mimic nonfunctioning pituitary macroadenomas and are occasionally incidentally discovered at autopsy. Pituitary adenomas can occur with other sellar pathologies, and the term "collision sellar lesions" has been coined for this rare entity. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.12.085DOI Listing

Updates in the Medical Treatment of Pituitary Adenomas.

Horm Metab Res 2020 Jan 20;52(1):8-24. Epub 2019 Dec 20.

Northwest Pituitary Center, and Departments of Medicine (Endocrinology) and Neurological Surgery, Oregon Health & Science University, Portland, United States.

Pituitary adenomas represent approximately 15% of brain tumors; incidence is significantly on the increase due to widespread use of magnetic resonance imaging. Surgery remains the first-line treatment for most tumors overall. The role of dopaminergic agonists (DAs) and somatostatin receptor ligands (SRLs) in the treatment of pituitary adenomas is quite well established for prolactinomas and growth hormone (GH) excess. Read More

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http://dx.doi.org/10.1055/a-1066-4592DOI Listing
January 2020

Postoperative Symptoms and Quality of Life in Pituitary Macroadenomas Patients.

J Neurosci Nurs 2020 Feb;52(1):30-36

Min Kyeong Jang, PhD RN KOAPN, is Postdoctoral Fellow, College of Nursing, University of Illinois at Chicago College of Nursing and University of Illinois Cancer Center, Chicago, IL. Eui Geum Oh, PhD RN FAAN, is Professor, Mo-Im Kim Nursing Research Institute, Yonsei University College of Nursing, Seoul, Republic of Korea. HyangKyu Lee, PhD RN, is Associate Professor, Mo-Im Kim Nursing Research Institute, Yonsei University College of Nursing, Seoul, Republic of Korea. Eui Hyun Kim, MD, PhD, is Assistant Professor, Department of Neurosurgery, Pituitary Tumor Center, Yonsei Endocrine Research Institute, Yonsei University College of Medicine, Seoul, Republic of Korea.

Background: Patients with pituitary macroadenoma commonly experience symptoms such as headache, visual disturbance, and olfactory dysfunction due to tumor effects. Even after undergoing surgery for tumor removal, patients continue to experience these symptoms and have difficulty resuming their general activities, decreasing their quality of life (QOL). Although some studies have focused on QOL in pituitary macroadenoma, few studies have examined the relationship between postoperative symptoms and patient QOL in the period after surgery. Read More

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http://dx.doi.org/10.1097/JNN.0000000000000483DOI Listing
February 2020

The Testosterone Effect on Metabolic and Urologic Outcomes in Patients with Nonfunctioning Pituitary Macroadenomas and Hypogonadotropic Hypogonadism.

Int J Endocrinol 2019 3;2019:2356580. Epub 2019 Nov 3.

Endocrinology Department, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico.

Objective: To evaluate cardiovascular risk, metabolic profile, low urinary tract symptoms (LUTS), and sexual function in patients with nonfunctional pituitary macroadenoma (NFPMA) and hypogonadotropic hypogonadism with testosterone therapy (TTh).

Methods: A retrospective clinical study at a tertiary care center was performed in 101 men with NFPMA, HH, and TTh; metabolic profile, cardiovascular risk, International Prostate Symptoms Score (IPSS), and International Index of Erectile Function 5 (IIEF-5) scores were evaluated before initiation of TTh and at the last checkup with TTh.

Results: Age was 49. Read More

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http://dx.doi.org/10.1155/2019/2356580DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6875227PMC
November 2019

Determinants of outcome of transsphenoidal surgery for Cushing disease in a single-centre series.

J Endocrinol Invest 2020 May 26;43(5):631-639. Epub 2019 Nov 26.

Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Endocrinology Unit, Via Francesco Sforza, 35, Milan, 20143, Italy.

Background: First-line therapy of Cushing disease (CD) is transsphenoidal surgery (TSS) aimed to obtain a complete removal of the pituitary adenoma and remission of disease.

Purpose: To analyse the surgical outcome of patients with CD who underwent TSS in our Centre.

Methods: Retrospective analysis on patients with CD who underwent TSS between 1990 and 2016. Read More

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http://dx.doi.org/10.1007/s40618-019-01151-1DOI Listing

Optical Coherence Tomography May Help Distinguish Glaucoma from Suprasellar Tumor-Associated Optic Disc.

J Ophthalmol 2019 29;2019:3564809. Epub 2019 Oct 29.

Department of Ophthalmology, Rabin Medical Center-Beilinson Hospital, Petah Tikva, Israel.

Purpose: This study aimed to differentiate patients with bilateral disc cupping associated with suprasellar tumor from patients with open-angle glaucoma by analyzing differences in optical coherence tomography (OCT) of the optic nerve.

Methods: In this retrospective cross-sectional study, we collected data from the eyes of 25 patients with suprasellar craniopharyngioma or pituitary macroadenomas (group 1) and 35 patients with primary open-angle glaucoma (POAG) (group 2), seen between 2001 and 2015, all with a visual acuity of ≥20/40, for whom Stratus Time-Domain (TD) optic nerve OCT scans were available. The main outcome measures were the retinal nerve fiber layer (RNFL) thickness, disc area, cup volume, cup/disc ratio, and rim area. Read More

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http://dx.doi.org/10.1155/2019/3564809DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6854909PMC
October 2019