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    1247 results match your criteria Pituitary Macroadenomas

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    Pediatric prolactinoma: initial presentation, treatment, and long-term prognosis.
    Eur J Pediatr 2017 Nov 22. Epub 2017 Nov 22.
    Department of Pediatrics and Pediatric Hematology/Oncology, Klinikum Oldenburg AöR, Medical Campus University Oldenburg, Rahel-Straus-Strasse 10, 26133, Oldenburg, Germany.
    Prolactinoma is a rare pituitary adenoma secreting prolactin. Studies on diagnostics, treatment, and prognosis in pediatric prolactinoma patients are rare. We analyzed clinical presentation, response to treatment, and prognosis of 27 pediatric prolactinoma patients (10 m/17 f. Read More

    Variability and Lack of Prognostic Value Associated With Atypical Pituitary Adenoma Diagnosis: A Systematic Review and Critical Assessment of the Diagnostic Criteria.
    Neurosurgery 2017 Nov 18. Epub 2017 Nov 18.
    Department of Neurosurgery, Keck School of Medicine of USC, Los Angeles, California.
    Background: Atypical pituitary adenomas (APAs) are a subset of pituitary adenomas (PAs) characterized by the 2004 World Health Organization (WHO) guidelines to have higher risk histopathological features than typical PAs. In July 2017, the WHO published an update to their classification of pituitary tumors and abandoned the APA terminology.

    Objective: To assess the prevalence and outcomes of patients diagnosed with APA through a literature review. Read More

    Early versus late Gamma Knife radiosurgery following transsphenoidal surgery for nonfunctioning pituitary macroadenomas: a multicenter matched-cohort study.
    J Neurosurg 2017 Oct 27:1-10. Epub 2017 Oct 27.
    Department of Neurosurgery, University of Virginia Health System, Charlottesville, Virginia.
    OBJECTIVE Gamma Knife radiosurgery (GKRS) is frequently used to treat residual or recurrent nonfunctioning pituitary macroadenomas. There is no consensus as to whether GKRS should be used early after surgery or if radiosurgery should be withheld until there is evidence of imaging-defined progression of tumor. Given the high incidence of adenoma progression after subtotal resection over time, the present study intended to evaluate the effect of timing of radiosurgery on outcome. Read More

    AIP mutations in Brazilian patients with sporadic pituitary adenomas: a single-center evaluation.
    Endocr Connect 2017 Oct 26. Epub 2017 Oct 26.
    M Gadelha, Internal Medicine and Endocrine Unit, Universidade Federal do Rio de Janeiro Hospital Universitario Clementino Fraga Filho, Rio de Janeiro, Brazil.
    Aryl hydrocarbon receptor-interacting protein (AIP) gene mutations (AIPmut) are the most frequent germline mutations found in apparently sporadic pituitary adenomas (SPA). Our aim was to evaluate the frequency of AIPmut among young Brazilian patients with SPA. We performed an observational cohort study between 2013-2016 in a single referral center. Read More

    The learning curve for endoscopic trans-sphenoidal resection of pituitary macroadenomas. A single institution experience, Leeds, UK.
    Acta Neurochir (Wien) 2017 Oct 23. Epub 2017 Oct 23.
    Department of Neurosurgery, Leeds General Infirmary, G Floor, Jubilee Building, Leeds, LS1 3EX, UK.
    Background: The object of this study was to assess whether increasing operative experience results in greater endoscopic trans-sphenoidal resection of pituitary macroadenomas and lower complications.

    Methods: A retrospective single institution cohort study was performed. Subjects underwent endoscopic trans-sphenoidal resection of pituitary macroadenoma between July 2009 and July 2016 by three neurosurgeons. Read More

    Dogs with macroadenomas have lower body temperature and heart rate than dogs with microadenomas.
    Vet J 2017 Sep 25;227:42-45. Epub 2017 Aug 25.
    The Royal Veterinary College, Hawkshead Lane, Hatfield, Hertfordshire AL9 7TA, United Kingdom and Cave Veterinary Specialists, George's Farm Nr Wellington, West Buckland, Wellington TA21 9LE, UK. Electronic address:
    Pituitary macroadenomas compress the hypothalamus, which partly regulates heart rate and body temperature. The aim of this study was to investigate whether heart rate and/or body temperature could aid in clinically differentiating dogs with macroadenomas from dogs with microadenomas (i.e. Read More

    Potential utility of FLAIR in MRI-negative Cushing's disease.
    J Neurosurg 2017 Oct 13:1-9. Epub 2017 Oct 13.
    Neurosurgery Unit for Pituitary and Inheritable Diseases, and.
    OBJECTIVE Accurate presurgical localization of microadenomas in Cushing's disease (CD) leads to improved remission rates and decreased adverse events. Volumetric gradient recalled echo (3D-GRE) MRI detects pituitary microadenomas in CD in up to 50%-80% cases as a focus of hypointensity due to delayed contrast wash-in. The authors have previously reported that postcontrast FLAIR imaging may be useful in detecting otherwise MRI-negative pituitary microadenomas as foci of hyperintensity. Read More

    [Familial isolated pituitary adenomas (FIPA). Case report of four families and review of literature.]
    Endokrynol Pol 2017 Oct 12. Epub 2017 Oct 12.
    Katedra i Klinika Endokrynologii Uniwersytetu Medycznego w Lublinie.
    BackgroundThe majority of pituitary adenomas are sporadic, but about 5% of them occur in a familial setting, predominantly in multiple endocrine neoplasia type 1 and Carney complex. Familial isolated pituitary adenomas (FIPA), unrelated to the syndromes mentioned above, were also described. The clinical course of FIPA differs significantly from sporadic cases, and is characterized by a larger tumor size, more aggressive course and younger patients' age at the moment of recognition. Read More

    Diagnosis and treatment of TSH-secreting adenomas: review of a longtime experience in a reference center.
    J Endocrinol Invest 2017 Oct 11. Epub 2017 Oct 11.
    Neuroendocrine Unit, Division of Endocrinology and Metabolism, Escola Paulista de Medicina, Universidade Federal de São Paulo, Rua Botucatu, 806, Vila Clementino, São Paulo, CEP 04023-062, Brazil.
    Purpose: TSH-secreting pituitary adenomas are among the less prevalent pituitary tumors, corresponding to 0.9-1.5% of all pituitary adenomas in surgical series. Read More

    [Overgrowth in children and in adults: novel clinical view, novel genes, novel phenotypes].
    Cas Lek Cesk 2017 ;156(5):233-240
    Novel genetic findings allow to more reliably elucidate the aetiology and pathogenesis of overgrowth syndromes in children and in adults. The relatively prevalent overgrowth syndromes in foetuses and neonates include Beckwith-Wiedemann (BWS) and Sotos syndromes; in addition, several rare conditions may occur e.g. Read More

    Morbidity and mortality in patients with hyperprolactinaemia: the PROLEARS study.
    Endocr Connect 2017 Nov;6(8):580-588
    Division of Molecular and Clinical MedicineSchool of Medicine, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK.
    Purpose: High serum prolactin concentrations have been associated with adverse health outcomes in some but not all studies. This study aimed to examine the morbidity and all-cause mortality associated with hyperprolactinaemia.

    Methods: A population-based matched cohort study in Tayside (Scotland, UK) from 1988 to 2014 was performed. Read More

    Diagnosis and Outcomes of 341 Patients with Cushing's Disease Following Transsphenoid Surgery: A Single-Center Experience.
    World Neurosurg 2017 Sep 23. Epub 2017 Sep 23.
    Department of Neurosurgery, Chinese Academy of Medical Sciences and Peking Union Medical College, Peking Union Medical College Hospital, Beijing, China. Electronic address:
    Background: Transsphenoid surgery (TSS) is a standard treatment modality for Cushing's disease (CD). However, postoperative remission and recurrence rates vary among studies. Here we analyze the diagnosis and outcomes of 341 patients with a preoperative diagnosis of CD undergoing TSS in a single center over a 3-year period. Read More

    Microsurgical versus endoscopic transsphenoidal resection for acromegaly: a systematic review of outcomes and complications.
    Acta Neurochir (Wien) 2017 Nov 14;159(11):2193-2207. Epub 2017 Sep 14.
    Department of Neurosurgery, Ronald Reagan UCLA Medical Center, Los Angeles, CA, USA.
    Purpose: The aim of this systematic review is to evaluate the long-term endocrine outcomes and postoperative complications following endoscopic vs. microscopic transsphenoidal resection (TSR) for the treatment of acromegaly.

    Methods: A literature review was performed, and studies with at least five patients who underwent TSR for acromegaly, reporting biochemical remission criteria and long-term remission outcomes were included. Read More

    MGMT and MSH6 immunoexpression for functioning pituitary macroadenomas.
    Pituitary 2017 Dec;20(6):643-653
    Department of Neurosurgery, Medical University Vienna, Waehringer Guertel 18-20, 1097, Vienna, Austria.
    Purpose: Knowledge of biological behavior is crucial for clinical management of functioning pituitary macroadenomas. For recurrent cases unresponsive to standard treatment, temozolomide (TMZ) has been used as a therapeutic alternative. MGMT (O6-methyl-guanine-DNA methyltransferase) and MSH6 (mutS homolog 6) immunoexpression have been linked to the response to TMZ treatment and MGMT immunoexpression has been additionally linked to early recurrence of non-functioning pituitary adenomas. Read More

    Endoscopic Transsphenoidal Approach for Acromegaly: Remission Rates in 401 Patients: 2010 Consensus Criteria.
    World Neurosurg 2017 Sep 5. Epub 2017 Sep 5.
    Kocaeli University Pituitary Research Centre and Neurosurgery Department. Electronic address:
    Background: Transsphenoidal surgery is the first choice treatment for acromegaly. Postoperative remission is an important predictor of outcome. Various factors have been described as markers of remission preoperative mean growth hormone (GH) and insulin-like growth factor-1 levels, cavernous sinus invasion, tumor size, extra pseudocapsule resection, and experience of the surgeon. Read More

    Prolonged preoperative treatment of acromegaly with Somatostatin analogs may improve surgical outcome in patients with invasive pituitary macroadenoma (Knosp grades 1-3): a retrospective cohort study conducted at a single center.
    BMC Endocr Disord 2017 Sep 6;17(1):55. Epub 2017 Sep 6.
    Key Laboratory of Endocrinology, Ministry of Health; Department of Endocrinology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, 100730, China.
    Background: This study aimed to investigate preoperative somatostatin analogs (SSAs) treatment on the surgical outcome in patients with acromegaly.

    Methods: An analysis of 358 patients with acromegaly was conducted. The preoperative medical therapy group (81 patients) received SSA treatment for at least 3 months prior to surgery, while the primary surgery group (277 patients) underwent transsphenoidal surgery directly. Read More

    Reoperation for growth hormone-secreting pituitary adenomas: report on an endonasal endoscopic series with a systematic review and meta-analysis of the literature.
    J Neurosurg 2017 Sep 1:1-13. Epub 2017 Sep 1.
    Department of Neurosurgery, Weill Cornell Medical College, NewYork-Presbyterian Hospital, New York, New York.
    OBJECTIVE Surgery is generally the first-line therapy for acromegaly. For patients with residual or recurrent tumors, several treatment options exist, including repeat surgery, medical therapy, and radiation. Reoperation for recurrent acromegaly has been associated with poor results, with hormonal control usually achieved in fewer than 50% of cases. Read More

    Surgical debulking of pituitary adenomas improves responsiveness to octreotide lar in the treatment of acromegaly.
    Pituitary 2017 Dec;20(6):668-675
    Division of MEND, University of Michigan, 24 Frank Lloyd Wright, G-1500, Ann Arbor, MI, 48106, USA.
    Background: Studies comparing primary medical treatment of acromegaly with surgery are often non-randomized, and not stratified by illness severity. We prospectively compared primary medical therapy with pituitary surgery in patients with acromegaly. All patients had macroadenomas, at least one random human growth hormone (GH) level ≥12. Read More

    Resection of pituitary macroadenomas via the pseudocapsule along the posterior tumor margin: a cohort study and technical note.
    J Neurosurg 2017 Aug 18:1-7. Epub 2017 Aug 18.
    Department of Neurological Surgery, University of Virginia Health System, Charlottesville, Virginia.
    OBJECTIVE Extracapsular resection of pituitary microadenomas improves remission rates, but the application of pseudocapsular techniques for macroadenomas has not been well described. In larger tumors, the extremely thin, compressed normal gland or its complete absence along the tumor's anterior surface limits the application of the traditional pseudocapsular technique that can be used for microadenomas. However, in the authors' experience, the interface between the pseudocapsule at the posterior margin of the adenoma and the compressed normal gland behind it is universally present, providing a surgical dissection plane. Read More

    Risk factors and the prognosis of sexual dysfunction in male patients with pituitary adenomas: a multivariate analysis.
    Asian J Androl 2017 Aug 11. Epub 2017 Aug 11.
    Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China.
    The impact of sexual dysfunction (SD) is distressing to many male patients with pituitary adenomas which affect both physical and psychological health. The research explored to identify risk factors affecting sexual function and the prognosis of male patients with pituitary adenomas. Two hundred and fifty-four male patients, who aged between 18 and 60 (mean ± s. Read More

    Long-term treatment outcomes of acromegaly patients presenting biochemically-uncontrolled at a tertiary pituitary center.
    BMC Endocr Disord 2017 Aug 4;17(1):49. Epub 2017 Aug 4.
    Pituitary Center, Cedars-Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA, 90048, USA.
    Background: Acromegaly is a rare, slowly progressive disorder resulting from excessive growth hormone (GH) production by a pituitary somatotroph tumor. The objective of this study was to examine acromegaly treatment outcomes during long-term care at a specialized pituitary center in patients presenting with lack of biochemical control.

    Methods: Data came from an acromegaly registry at the Cedars-Sinai Medical Center Pituitary Center (center). Read More

    Prevalence, Clinical Features, and Natural History of Incidental Clinically Non-Functioning Pituitary Adenomas.
    Horm Metab Res 2017 Sep 31;49(9):654-659. Epub 2017 Jul 31.
    Department of Endocrinology, Hospital Universitario A Coruña, A Coruña, Spain.
    The objective of the study was to assess the prevalence and clinical features of incidentally discovered clinically non-functioning pituitary adenoma (CNFPA) and to analyze its natural history. A multicenter retrospective study in patients diagnosed with incidental CNFPA periodically followed-up in 3 specialized neuroendocrinology units from 1992 to 2015 was performed. Out of a total of 189 CNFPA patients, 57 cases (30. Read More

    Radiological Growth Patterns of Prolactinomas and Nonfunctioning Adenomas.
    Can J Neurol Sci 2017 Sep 3;44(5):508-513. Epub 2017 Jul 3.
    1Division of Endocrinology and Metabolism,Dalhousie University,Halifax,Nova Scotia,Canada.
    Objectives: To compare growth patterns of nonfunctioning and prolactin-producing pituitary macroadenomas, and to find whether their specific growth patterns are associated with clinically significant effects on vision.

    Materials And Methods: From our comprehensive provincial neuropituitary registry, we retrospectively identified 35 randomly selected patients each with nonfunctioning adenomas and prolactinomas >10 mm in any dimension. MRI scans were analyzed to determine the superior and inferior growth, volume, and maximum craniocaudal height of the adenomas. Read More

    Prolactinomas diagnosed in the postmenopausal period: Clinical phenotype and outcomes.
    Clin Endocrinol (Oxf) 2017 Nov 18;87(5):508-514. Epub 2017 Jul 18.
    Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.
    Objective: Most prolactinomas in females are diagnosed during the reproductive age, and the majority are microadenomas. Prolactinomas detected in the postmenopausal period are less common with limited published data on their presentation and prognosis. Our objective was to assess the presenting clinical, biochemical and imaging findings, as well as the outcomes of women diagnosed with a prolactinoma in the postmenopausal period. Read More

    Cavernous Sinus Involvement by Pituitary Adenomas: Clinical Implications and Outcomes of Endoscopic Endonasal Resection.
    J Neurol Surg B Skull Base 2017 Jun 23;78(3):273-282. Epub 2017 Jan 23.
    Department of Neurosurgery, Stanford University School of Medicine, Stanford, California, United States.
    Background  Parasellar invasion of pituitary adenomas (PAs) into the cavernous sinus (CS) is common. The management of the CS component of PA remains controversial. Objective  The objective of this study was to analyze CS involvement in PA treated with endoscopic endonasal approaches, including incidence, surgical risks, surgical strategies, long-term outcomes, and our treatment algorithm. Read More

    Long term follow-up of growth hormone-secreting pituitary adenomas submitted to endoscopic endonasal surgery.
    Arq Neuropsiquiatr 2017 May;75(5):301-306
    Faculdade de Ciências Médicas, Santa Casa de São Paulo, Departamento de Otorrinolaringologia São Paulo SP, Brasil.
    Objective: The aim of this study was to evaluate the results of the endoscopic transsphenoidal technique for growth hormone (GH)-secreting adenomas.

    Methods: A retrospective analysis based on medical records of 23 acromegalic patients submitted to endoscopic transsphenoidal surgery. Biochemical control was defined as basal GH < 1ng/ml, nadir GH < 0. Read More

    Acromegaly: surgical results in 548 patients.
    Pituitary 2017 Oct;20(5):522-528
    Neurosurgery Department, Puerta de Hierro Hospital, Madrid, Spain.
    Purpose: The goal of this study was to quantified the results of microsurgery, in all the patients with acromegaly treated by the same endocrinologist and the same surgeon between 1975 and 2015.

    Methods: A series of 548 patients with acromegaly were operated and followed-up from 6 months to 40 years. Patients were selected according to five criteria: (1) Operated by the same surgeon. Read More

    Korsakoff syndrome from retrochiasmatic suprasellar lesions: rapid reversal after relief of cerebral compression in 4 cases.
    J Neurosurg 2017 Jun 2:1-6. Epub 2017 Jun 2.
    Departments of 1 Neurosurgery and.
    Korsakoff syndrome is a chronic memory disorder caused by a severe deficiency of thiamine that is most commonly observed in alcoholics. However, some have proposed that focal structural lesions disrupting memory circuits-in particular, the mammillary bodies, the mammillothalamic tract, and the anterior thalamus-can give rise to this amnestic syndrome. Here, the authors present 4 patients with reversible Korsakoff syndromes caused by suprasellar retrochiasmatic lesions compressing the mammillary bodies and adjacent caudal hypothalamic structures. Read More

    Loss-of-function mutations in the CABLES1 gene are a novel cause of Cushing's disease.
    Endocr Relat Cancer 2017 Aug 22;24(8):379-392. Epub 2017 May 22.
    Section on Endocrinology and GeneticsEunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH), Bethesda, Maryland, USA
    The CABLES1 cell cycle regulator participates in the adrenal-pituitary negative feedback, and its expression is reduced in corticotropinomas, pituitary tumors with a largely unexplained genetic basis. We investigated the presence of CABLES1 mutations/copy number variations (CNVs) and their associated clinical, histopathological and molecular features in patients with Cushing's disease (CD). Samples from 146 pediatric (118 germline DNA only/28 germline and tumor DNA) and 35 adult (tumor DNA) CD patients were screened for CABLES1 mutations. Read More

    Perioperative hypothalamic pituitary adrenal function in patients with silent corticotroph adenomas.
    Pituitary 2017 Aug;20(4):471-476
    Division of Clinical and Molecular Endocrinology, University Hospitals Cleveland Medical Center and Case Western Reserve University, Cleveland, OH, 44106, USA.
    Background: Silent corticotroph adenomas (SCAs) are characterized by strong ACTH immunostaining without clinical manifestations of hypercortisolism. Patients with SCAs often present with mechanical symptoms related to tumor growth. This study investigates the hypothalamic pituitary adrenal axis (HPA) characteristics after adenomectomy in patients with SCAs. Read More

    Preliminary experience with 4K ultra-high definition endoscope: analysis of pros and cons in skull base surgery.
    Acta Otorhinolaryngol Ital 2017 Jun;37(3):237-241
    Institute of Otorhinolaryngology, Catholic University School of Medicine, Rome, Italy.
    During the last two decades endoscopic skull base surgery observed a continuous technical and technological development 3D endoscopy and ultra High Definition (HD) endoscopy have provided great advances in terms of visualisation and spatial resolution. Ultra-high definition (UHD) 4K systems, recently introduced in the clinical practice, will shape next steps forward especially in skull base surgery field. Patients were operated on through transnasal transsphenoidal endoscopic approaches performed using Olympus NBI 4K UHD endoscope with a 4 mm 0° Ultra Telescope, 300 W xenon lamp (CLV-S400) predisposed for narrow band imaging (NBI) technology connected through a camera head to a high-quality control unit (OTV-S400 - VISERA 4K UHD) (Olympus Corporation, Tokyo, Japan). Read More

    Different patterns of gelatinolytic activity in pituitary macro- and microadenomas.
    Clin Neurol Neurosurg 2017 Jul 4;158:90-92. Epub 2017 May 4.
    Department of Medical Chemistry, Medical University of Lublin, Chodźki 4, 20-093 Lublin, PL, Poland. Electronic address:
    Objective: Gelatinases, Matrix MetalloProteinase(MMP)-2 and MMP-9, belong to zinc-dependent endopeptidases involved in several physiological and pathological processes including inflammation and tumor development. Because the information about the involvement of gelatinases in pituitary adenoma (PA) development are scant, our objective was the analysis of MMP-2 and MMP-9 activity in serum and tumor tissue of PA patients.

    Patients And Methods: Twenty one patients with PA (macroadenoma n=18, microadenoma n=3), qualified to the endoscopic resection of tumors were enrolled. Read More

    Role of High-Resolution Dynamic Contrast-Enhanced MRI with Golden-Angle Radial Sparse Parallel Reconstruction to Identify the Normal Pituitary Gland in Patients with Macroadenomas.
    AJNR Am J Neuroradiol 2017 Jun 11;38(6):1117-1121. Epub 2017 May 11.
    From the New York University School of Medicine, NYU Langone Medical Center, New York, New York.
    Background And Purpose: Preoperative localization of the pituitary gland with imaging in patients with macroadenomas has been inadequately explored. The pituitary gland enhancing more avidly than a macroadenoma has been described in the literature. Taking advantage of this differential enhancement pattern, our aim was to evaluate the role of high-resolution dynamic MR imaging with golden-angle radial sparse parallel reconstruction in localizing the pituitary gland in patients undergoing trans-sphenoidal resection of a macroadenoma. Read More

    AIP mutations and gigantism.
    Ann Endocrinol (Paris) 2017 Jun 5;78(2):123-130. Epub 2017 May 5.
    Department of Endocrinology, Centre Hospitalier Universitaire de Liège, University of Liège, Domaine Universitaire du Sart-Tilman, 4000 Liège, Belgium. Electronic address:
    AIP mutations are rare in sporadic acromegaly but they are seen at a higher frequency among certain specific populations of pituitary adenoma patients (pituitary gigantism cases, familial isolated pituitary adenoma (FIPA) kindreds, and patients with macroadenomas who are diagnosed ≤30 years). AIP mutations are most prevalent in patients with pituitary gigantism (29% of this group were found to have mutations in AIP gene). These data support targeted genetic screening for AIP mutations/deletions in these groups of pituitary adenoma patients. Read More

    Younger age is a risk factor for regrowth and recurrence of nonfunctioning pituitary macroadenomas: Results from a single Australian centre.
    Clin Endocrinol (Oxf) 2017 Sep 31;87(3):264-271. Epub 2017 May 31.
    Department of Endocrinology & Diabetes, St Vincent's Hospital Melbourne, Melbourne, Victoria, Australia.
    Objective: The natural history of nonfunctioning pituitary macroadenomas (NFPMA) after surgical resection is variable, with guidelines unable to define the duration of radiological follow-up. In this first Australian series, we identify risk factors for regrowth/recurrence of NFPMA to assist with guiding recommendations for long-term follow-up.

    Design: Retrospective analysis of all radiotherapy-naïve cases with NFPMA resected between 1995 and 2013. Read More

    Outcome of Endoscopic Transsphenoidal Surgery for Acromegaly.
    World Neurosurg 2017 Aug 29;104:272-278. Epub 2017 Apr 29.
    Pituitary Center, Seoul National University College of Medicine, Seoul, Korea; Department of Neurosurgery, Seoul National University College of Medicine, Seoul, Korea. Electronic address:
    Objective: Endoscopic transsphenoidal surgery has recently been introduced in pituitary surgery. We investigated outcomes and complications of endoscopic surgery in 2 referral centers in Korea.

    Methods: We enrolled 134 patients with acromegaly (microadenomas, n = 15; macroadenomas, n = 119) who underwent endoscopic transsphenoidal surgery at Seoul National University Hospital (n = 74) and Samsung Medical Center (n = 60) between January 2009 and March 2016. Read More

    Non-functioning pituitary adenoma underwent surgery: A multicenter retrospective study over the last four decades (1977-2015).
    Eur J Intern Med 2017 Jun 25;41:62-67. Epub 2017 Apr 25.
    Department of Endocrinology, Hospital Universitario de Bellvitge, Barcelona, Spain.
    Objective: To assess clinical features, diagnostic procedures, therapies and outcomes in patients with clinically non-functioning pituitary adenomas (NFPAs) surgically treated over the last four decades.

    Design And Methods: A multicenter retrospective study in NFPA patients periodically followed up in specialized neuroendocrinology units who underwent surgery in the period 1977-2015 was performed.

    Results: A total of 131 patients were studied [66 women (50. Read More

    Transcriptome Analysis Showed a Differential Signature between Invasive and Non-invasive Corticotrophinomas.
    Front Endocrinol (Lausanne) 2017 22;8:55. Epub 2017 Mar 22.
    Laboratory of Hormones and Molecular Genetics LIM-42, University of São Paulo Medical School, São Paulo, Brazil; Endocrinology Service, AC Cancer Center, São Paulo, Brazil.
    ACTH-dependent hypercortisolism caused by a pituitary adenoma [Cushing's disease (CD)] is the most common cause of endogenous Cushing's syndrome. CD is often associated with several morbidities, including hypertension, diabetes, osteoporosis/bone fractures, secondary infections, and increased cardiovascular mortality. While the majority (≈80%) of the corticotrophinomas visible on pituitary magnetic resonance imaging are microadenomas (MICs, <10 mm of diameter), some tumors are macroadenomas (MACs, ≥10 mm) with increased growth potential and invasiveness, exceptionally exhibiting malignant demeanor. Read More

    Long-Term Endocrine Outcomes Following Endoscopic Endonasal Transsphenoidal Surgery for Acromegaly and Associated Prognostic Factors.
    Neurosurgery 2017 Aug;81(2):357-366
    Department of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, Cali-fornia.
    Background: Long-term remission rates from endoscopic transsphenoidal surgery for acromegaly and their relationship to prognostic indicators of disease aggressiveness are not well documented.

    Objective: To investigate long-term remission rates in patients with acromegaly after endoscopic transsphenoidal surgery, and correlate this with molecular and radiographic markers of disease aggressiveness.

    Methods: We identified all patients undergoing endoscopic transsphenoidal surgery for acromegaly from 2005 to 2013 at Cedars-Sinai Pituitary Center. Read More

    Operative Strategies to Minimize Complications Following Resection of Pituitary Macroadenomas.
    J Neurol Surg B Skull Base 2017 Apr 7;78(2):184-190. Epub 2016 Dec 7.
    Department of Neurosurgery, University of Pennsylvania, Philadelphia, Pennsylvania, United States.
    Introduction We sought to identify factors associated with increased length of stay (LOS) and morbidity in patients undergoing resection of pituitary macroadenomas. Methods We reviewed records of 203 consecutive patients who underwent endoscopic endonasal resection of a pituitary macroadenoma (mean age = 55.7 [16-88]) years, volume = 11. Read More

    Efficacy of transsphenoidal surgery in achieving biochemical cure of growth hormone-secreting pituitary adenomas among patients with cavernous sinus invasion: a systematic review and meta-analysis.
    Neurol Res 2017 May 16;39(5):387-398. Epub 2017 Mar 16.
    a Department of Pharmaceutical Business and Administrative Sciences , MCPHS University , Boston , MA , USA.
    Objectives: Growth hormone-secreting pituitary adenomas in adults can result in severe craniofacial disfigurement and potentially fatal medical complications. Surgical resection leading to remission of the disease is dependent on complete surgical resection of the tumor. Lesions that invade the cavernous sinus may not be safely accessible via an endonasal transsphenoidal surgery (TSS), and the rates of biochemical remission of patients with residual disease vary widely in the literature. Read More

    Surgical outcomes in patients with Cushing's disease: the Cleveland clinic experience.
    Pituitary 2017 Aug;20(4):430-440
    Department of Neurosurgery, the Neurological Institute, Cleveland Clinic, Cleveland, OH, USA.
    Context: Transsphenoidal surgery (TSS) to resect a pituitary adenoma is considered first-line treatment for patients with Cushing's disease (CD). Early, post-operative remission rates >80% are expected for patients with a microadenoma (≤ 10 mm) visible on magnetic resonance (MR) imaging.

    Objective: To report surgical outcomes and predictors of remission in a specialist center for patients with CD. Read More

    Does Low-Field Intraoperative Magnetic Resonance Improve the Results of Endoscopic Pituitary Surgery? Experience of the Implementation of a New Device in a Referral Center.
    World Neurosurg 2017 Jun 27;102:102-110. Epub 2017 Feb 27.
    Department of Neurosurgery, Hospital Clínic de Barcelona, Barcelona, Spain.
    Objective: To assess the contribution of low-field intraoperative magnetic resonance (iMRI) to endoscopic pituitary surgery.

    Methods: We analyzed a prospective series of patients undergoing endoscopic endonasal surgery for pituitary macroadenomas assisted with a low-field iMRI (PoleStarN30, 0.15 T [Medtronic]). Read More

    [Treatment effects analysis of preoperative long-acting somatostatin analogs combined trans-sphenoidal endoscopic surgery for patients with growth hormone secreting pituitary macroadenomas].
    Zhonghua Yi Xue Za Zhi 2017 Feb;97(5):375-379
    Department of neurosurgery and Endocrinology, Peking Union Medical College Hospital, Beijing 100730, China.
    Objective: To evaluate the treatment effects of preoperative long-acting somatostatin analogue (SSA) combined trans-sphenoidal endoscopic surgery for patients with growth hormone (GH)-secreting pituitary macroadenomas. Methods: Retrospective analysis was carried out on 20 patients with GH-secreting pituitary macroadenomas who were treated with preoperative SSA and trans-sphenoidal endoscopic surgery in our apartment from January 2010 to January 2016. We also selected 20 patients with only trans-sphenoidal endoscopic surgery treatment and 20 patients with preoperative SSA and non-trans-sphenoidal endoscopic surgery treatment. Read More

    Hypogonadotropic Hypogonadism in Non-Functioning Pituitary Adenomas: Impact of Intervention.
    Exp Clin Endocrinol Diabetes 2017 Jun 15;125(6):368-376. Epub 2017 Feb 15.
    Department of Endocrinology, Diabetes and Metabolism Centro Hospitalar S. João, Faculty of Medicine - Instituto de Investigação e Inovação em Saúde University of Porto,Portugal.
    To determine the prevalence of hypogonadotropic hypogonadism (HH) among patients with non-functioning pituitary adenomas (NFPA) and the post-surgery outcome on pituitary gonadotropins secretion (PGS); to determine the prevalence of erectile dysfunction (ED) on male patients with NFPA, to evaluate the impact of testosterone replacement therapy (TRT) in those with HH. Retrospective evaluation of gonadal function in 109 NFPA patients (45 males), with a mean age of 51.8 years, diagnosed on the last 10 years. Read More

    Endoscopic Endonasal Versus Microscopic Transsphenoidal Surgery for Recurrent and/or Residual Pituitary Adenomas.
    World Neurosurg 2017 May 6;101:186-195. Epub 2017 Feb 6.
    Department of Neurosurgery, Weill Cornell Medical College, Cornell University, New York-Presbyterian Hospital, New York, New York, USA; Department of Otolaryngology, Weill Cornell Medical College, Cornell University, New York-Presbyterian Hospital, New York, New York, USA; Department of Neuroscience, Weill Cornell Medical College, Cornell University, New York-Presbyterian Hospital, New York, New York, USA.
    Objective: Surgery for recurrent/residual pituitary adenomas is increasingly being performed through endoscopic surgery. Whether this new technology has altered the indications and outcomes of surgery is unknown. We conducted a systematic review and meta-analysis of published studies to compare the indications and outcomes between microscopic and endoscopic approaches. Read More

    Diagnosis and Treatment of Pituitary Adenomas: A Review.
    JAMA 2017 Feb;317(5):516-524
    Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
    Importance: Pituitary adenomas may hypersecrete hormones or cause mass effects. Therefore, early diagnosis and treatment are important.

    Observations: Prevalence of pituitary adenomas ranges from 1 in 865 adults to 1 in 2688 adults. Read More

    Efficacy of Microsurgical Sublabial Approach (MSA) Versus Endoscopic Endonasal Approach (EEA) for the Treatment of Pituitary Adenomas Based on Radiological and Hormonal Outcome.
    Acta Neurochir Suppl 2017 ;124:101-106
    Institute of Neurosurgery, Catholic University School of Medicine, Rome, Italy.
    Background: The purpose of this study was to compare the surgical efficacy of the microsurgical sublabial approach (MSA) versus the endoscopic endonasal approach (EEA) for the treatment of pituitary adenomas, based on short-term (12 months) radiological and endocrinological follow-up.

    Methods: One hundred and fourteen patients affected by pituitary adenoma were enrolled at our Unit between January 2007 and February 2012; 72 were treated with MSA, and 42 with EEA. The preoperative parameters considered were: type of lesion (secreting or nonsecreting), lesion size, presence of intralesional hemorrhage, lesion perimeter (nodular vs. Read More

    Clinical Features, Management Considerations and Outcomes in Case Series of Patients with Parasellar Intracranial Aneurysms Undergoing Anterior Skull Base Surgery.
    World Neurosurg 2017 Mar 10;99:424-432. Epub 2016 Dec 10.
    Department of Neurosurgery, University of Virginia, Charlottesville, Virginia, USA.
    Background: The coincidence of parasellar aneurysms (IAs) and anterior skull base (ASB) lesions, while rare, presents a management challenge. IAs embedded within, or adjacent to, ASB lesions are at risk in the perioperative period and may have unique presentations, natural histories, and outcomes. The objective of this study was to outline management options and nuances in patients with coexisting IAs and ASB lesions. Read More

    Prevalence and Predictors of Overweight and Obesity in Patients with Pituitary Dysfunctions.
    Endocr Metab Immune Disord Drug Targets 2016 ;16(4):249-253
    University of Luebeck, Department of Medicine I, Ratzeburger Allee 160, 23538 Luebeck, Germany.
    Background: Patients with hypothalamic-pituitary disorders (HPD) may be of increased risk to develop overweight and obesity, thereby fostering cardiovascular events. However, it remains unclear if patients with pituitary dysfunctions per se have an increased risk of becoming obese.

    Objective: The objective of this study was to evaluate prevalence and to identify possible predictors of overweight and obesity in patients with pituitary dysfunctions. Read More

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