76,751 results match your criteria Pituitary Gland


Dual liquid-liquid extraction followed by LC-MS/MS method for the simultaneous quantification of melatonin, cortisol, triiodothyronine, thyroxine and testosterone levels in serum: Applications to a photoperiod study in rats.

J Chromatogr B Analyt Technol Biomed Life Sci 2019 Jan 3;1108:11-16. Epub 2019 Jan 3.

Education, Science and Sport Department, Castilla-La Mancha, Spain.

Hypothalamic Pituitary (PH) axes directly affects the functionality of the thyroid gland, the adrenal gland, and the gonads and their alteration has been related to several pathologies. Therefore, the global analysis of representative hormones from each axis, together with melatonin, would be a very good strategy for therapeutic diagnosis. Hence, an accurate, economic and effective analytical method has been developed and validated for the simultaneous measurement of the melatonin, cortisol, triiodothyronine (T3), thyroxine (T4) and testosterone levels in serum. Read More

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http://dx.doi.org/10.1016/j.jchromb.2019.01.002DOI Listing
January 2019

A Case Report on Pituitary Apoplexy Presenting as Acute Kidney Injury.

Cureus 2018 Nov 13;10(11):e3583. Epub 2018 Nov 13.

Internal Medicine, Yuma Regional Medical Center, Yuma, USA.

Pituitary apoplexy is characterized by the acute ischemic or hemorrhagic infarction of the pituitary gland. Acute kidney injury is a less recognized complication associated with pituitary apoplexy but occasionally can be a presenting condition in patients with pituitary apoplexy. Here we discuss the case of a patient who presented with significant volume depletion, admitted with acute kidney injury, and was later diagnosed with pituitary apoplexy. Read More

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http://dx.doi.org/10.7759/cureus.3583DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334887PMC
November 2018
1 Read

Comparison of neuroendocrine dysfunction in patients with adamantinomatous and papillary craniopharyngiomas.

Exp Ther Med 2019 Jan 12;17(1):51-56. Epub 2018 Nov 12.

Department of Endocrinology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, P.R. China.

Craniopharyngiomas (CPs) are rare epithelial tumors mainly located in the sellar/parasellar region. They may be classified into two major histological subtypes, which exhibit clinical and pathological differences: Adamantinomatous CP (ACP) and papillary CP (PCP). The aim of the present study was to compare the neuroendocrine dysfunction between ACP and PCP prior to and after surgical resection. Read More

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http://dx.doi.org/10.3892/etm.2018.6953DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307520PMC
January 2019

Recurrent Chemical Meningitis Due to Parasellar Epidermoid Cyst.

Cureus 2018 Oct 25;10(10):e3496. Epub 2018 Oct 25.

Neurology, Harbor University of California Los Angeles Medical Center, Los Angeles, USA.

Intracranial epidermoid cysts are exceedingly rare lesions that result from a disorder of gastrulation. They are seen only in the pediatric patient population. We describe a 44-year-old Hispanic woman who presented with acute confusion. Read More

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https://www.cureus.com/articles/15574-recurrent-chemical-men
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http://dx.doi.org/10.7759/cureus.3496DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318134PMC
October 2018
1 Read

IgG4 related orbit disease - An unusual cause of an orbital mass.

Med J Malaysia 2018 Dec;73(6):415-417

Massachusetts General Hospital, Harvard Medical School, Boston MA, United States of America.

IgG4-related disease is a newly described systemic autoimmune and allergic disease, characterized histologically by a fibroinflammatory response with IgG4 plasma cells. It was initially described as affecting the pancreas, but commonly involves the head and neck region as well. While a biopsy is essential for definitive diagnosis, cross sectional imaging may be the initial modality which may suggest this entity. Read More

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December 2018

The diagnosis and management of central hypothyroidism in 2018.

Endocr Connect 2019 Jan 1. Epub 2019 Jan 1.

M Bonomi, Endocrine and Metabolic Diseases, Istituto Auxologico Italiano - Istituto Scientifico San Luca, Milano, Italy.

Central hypothyrodism (CeH) is a hypothyroid state caused by an insufficient stimulation by thyrotropin (TSH) of an otherwise normal thyroid gland. Several advancements, including the recent publication of expert guidelines for CeH diagnosis and management, have been made in recent years thus increasing the clinical awareness on this condition. Here we reviewed the recent advancements and give expert opinions on critical issues. Read More

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http://dx.doi.org/10.1530/EC-18-0515DOI Listing
January 2019
1 Read

[Psychosis and behavioural problems as first symptoms of brain tumour?]

Authors:
J Schildermans

Tijdschr Psychiatr 2019 ;61(1):53-56

A craniopharyngioma is a rare, slow-growing tumour in the pituitary gland. Brain tumours usually present with obvious neurological or other physical symptoms, whereas psychiatric symptoms as primary signs are rare. The presented case, in which psychosis and behavioural problems predominated, concerned a 42-year-old patient. Read More

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January 2019

Bipartite craniopharyngeal canal with a lipoma and cephalocele: a previously unreported entity.

Acta Neurochir (Wien) 2019 Jan 14. Epub 2019 Jan 14.

Department of Imaging Sciences and Interventional Radiology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Room no 318, Srishty building, SCTIMST Staff Quarters, Poondi Road, Kumarapuram Junction, Medical college (P.O), Trivandrum, Kerala, 695011, India.

A 13-year-old male child was evaluated for headache and visual deterioration; he underwent routine MRI imaging which revealed a large craniopharyngeal canal, divided by an abnormal bony septum giving a bipartite appearance of the canal, with a lipoma and cephalocele on either side of the septum. The child had undergone a previous surgery for cleft palate repair at the age of 7. The child had normal pituitary function inspite of nonvisualization of pituitary gland in MRI. Read More

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http://dx.doi.org/10.1007/s00701-018-03795-zDOI Listing
January 2019

Isolation stress impacts Met-enkephalin in the hypothalamo-pituitary-adrenocortical axis in growing Polish Mountain sheep: a possible role of the opioids in modulation of HPA axis.

Stress 2019 Jan 14:1-9. Epub 2019 Jan 14.

c Center of Excellence in Poultry Science, University of Arkansas , Fayetteville , AR , USA.

It was hypothesized that there is cross-talk between the classical constituents of the hypothalamo-pituitary-adrenocortical axis (HPA) and Met-enkephalin in the HPA axis. The study examined effects of isolation stress, sex, and age on concentrations of native Met-enkephalin and pro-enkephalin (PENK) gene expression in tissues of the HPA (hypothalamus, pituitary gland and adrenal cortex) in 3-, 6- and 9-month old female and male lambs. In addition, the effects of isolation stress on in vitro release Met-enkephalin from fragments of the hypothalamus or adrenal cortex were examined. Read More

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http://dx.doi.org/10.1080/10253890.2018.1553947DOI Listing
January 2019

Brain and Salivary Gland Tumors and Mobile Phone Use: Evaluating the Evidence from Various Epidemiological Study Designs.

Annu Rev Public Health 2019 Jan 11. Epub 2019 Jan 11.

Institute of Environmental Medicine, Karolinska Institutet, 171 77 Stockholm, Sweden.

Mobile phones (MPs) are the most relevant source of radiofrequency electromagnetic field (RF-EMF) exposure to the brain and the salivary gland. Whether this exposure implies a cancer risk has been addressed in several case-control and few cohort studies. A meta-analysis of these studies does not show increased risks for meningioma, pituitary, and salivary gland tumors. Read More

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https://www.annualreviews.org/doi/10.1146/annurev-publhealth
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http://dx.doi.org/10.1146/annurev-publhealth-040218-044037DOI Listing
January 2019
3 Reads

Isolated hypothalamic-pituitary langerhans' cell histiocytosis in female adult: A case report.

Medicine (Baltimore) 2019 Jan;98(2):e13853

Department of Endocrinology and Metabolism.

Rationale: Langerhans cell histiocytosis (LCH) is characterized by clonal proliferation of immature dendritic cells, mainly affects children. LCH in adult sellar region is extremely rare. In literature, optimal treatments remain unclear and only a few cases of LCH were treated using surgery. Read More

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http://dx.doi.org/10.1097/MD.0000000000013853DOI Listing
January 2019
2 Reads

Impact of P-glycoprotein Function on the Brain Kinetics of the Weak Substrate C-Metoclopramide Assessed with PET Imaging in Humans.

J Nucl Med 2019 Jan 10. Epub 2019 Jan 10.

Medical University of Vienna, Austria.

PET with avid substrates of P-glycoprotein (ABCB1) provided evidence of the role of this efflux transporter in effectively restricting the brain penetration of its substrates across the human blood-brain barrier (BBB). This may not reflect the situation for weak ABCB1 substrates including several antidepressants, antiepileptic drugs and neuroleptics, which exert CNS effects despite being transported by ABCB1. We performed PET with the weak ABCB1 substrate C-metoclopramide in humans to elucidate the impact of ABCB1 function on its brain kinetics. Read More

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http://dx.doi.org/10.2967/jnumed.118.219972DOI Listing
January 2019

Clinical Presentation and Pathologic Characteristics of Pituitary Metastasis From Breast Carcinoma: Cases and a Systematic Review of the Literature.

World Neurosurg 2019 Jan 7. Epub 2019 Jan 7.

Department of Neurosurgery, Shengjing Hospital of China Medical University, Shenyang 110004, People's Republic of China. Electronic address:

Background: It is rare for breast carcinoma to metastasize to the pituitary gland; this finding indicates extensive metastasis of the primary tumor.

Case Description: Herein, we present a 57year-old patient with pituitary gland metastasis from breast cancer that was treated with extensive radical mastectomy 16 years prior. The pituitary was the sole site of metastasis. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18788750183294
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http://dx.doi.org/10.1016/j.wneu.2018.12.126DOI Listing
January 2019
3 Reads

Perspectives on Endogenous Opioids in Birds.

Front Physiol 2018 21;9:1842. Epub 2018 Dec 21.

Department of Animal Physiology and Endocrinology, University of Agriculture in Krakow, Kraków, Poland.

The present review summarizes the state of knowledge of endogenous opioids in birds. Endogenous opioid peptides acts in a neuromodulatory, hormonal and paracrine manner to mediate analgesic and other physiological functions. These peptides act through specific G-protein coupled receptors. Read More

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https://www.frontiersin.org/article/10.3389/fphys.2018.01842
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http://dx.doi.org/10.3389/fphys.2018.01842DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6308189PMC
December 2018
2 Reads

Hyperglycemia Induced by Chronic Restraint Stress in Mice Is Associated With Nucleus Tractus Solitarius Injury and Not Just the Direct Effect of Glucocorticoids.

Front Neurosci 2018 19;12:983. Epub 2018 Dec 19.

Department of Histology, Embryology and Neurobiology, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu, China.

Chronic restraint stress (CRS) can affect hypothalamic-pituitary-adrenal (HPA) axis activity and increase glucocorticoid levels. Glucocorticoids are stress hormones that regulate multiple aspects of energy homeostasis. Stress also impairs glucose tolerance. Read More

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http://dx.doi.org/10.3389/fnins.2018.00983DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305899PMC
December 2018

The effects of cannabinoids on the endocrine system.

Endokrynol Pol 2018 ;69(6):705-719

Chair and Department of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, Poland.

Cannabinoids are the derivatives of the cannabis plant, the most potent bioactive component of which is tetrahydrocannabinol (THC). The most commonly used drugs containing cannabinoids are marijuana, hashish, and hashish oil. These compounds exert their effects via interaction with the cannabinoid receptors CB1 and CB2. Read More

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http://dx.doi.org/10.5603/EP.a2018.0072DOI Listing
January 2018

The art of oocyte meiotic arrest regulation.

Authors:
Bo Pan Julang Li

Reprod Biol Endocrinol 2019 Jan 5;17(1). Epub 2019 Jan 5.

Department of Animal Biosciences, University of Guelph, 50 Stone Road E, Building #70, Guelph, ON, N1G 2W1, Canada.

A central dogma of mammalian reproductive biology is that the size of the primordial follicle pool represents reproductive capacity in females. The assembly of the primordial follicle starts after the primordial germ cells (PGCs)-derived oocyte releases from the synchronously dividing germline cysts. PGCs initiate meiosis during fetal development. Read More

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http://dx.doi.org/10.1186/s12958-018-0445-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320606PMC
January 2019
1 Read

The role of Crooke's changes in recurrence and remission after gamma knife radiosurgery.

J Neurooncol 2019 Jan 3. Epub 2019 Jan 3.

Department of Neurological Surgery, University of Virginia, Room G512 1221 Lee St., Charlottesville, VA, 22908, USA.

Purpose: The objective of this study is to evaluate the role of Crooke's changes (CC) in normal the peri-tumoral anterior pituitary gland, in patients with Cushing's disease (CD) with a histopathological confirmed corticotroph adenoma, and determine if there is any difference in the recurrence and remission rates in CD patients after treatment with Gamma Knife Radiosurgery (GKRS).

Methods: All patients treated with GKRS for CD from 2005 to 2016 at our institution were identified. Patients had a confirmed adrenocorticotropic (ACTH)-secreting adenoma, i. Read More

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http://dx.doi.org/10.1007/s11060-018-03078-8DOI Listing
January 2019

Thyroid disease in the elderly.

Vnitr Lek 2018 ;64(11):993-1002

The incidence of most thyroid diseases are prevalent in women in ratio 8 : 1 to men, and especially hypothyroidism arises with age. Unrecognized thyroid dysfunction leads to increased: cardiovascular risk, bone fractures, cognitive impairment, depression, and mortality. The symptoms of thyroid diseases can be nonspecific or common in seniors with ageing complaints. Read More

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January 2018
1 Read

Acute restraint stress triggers progesterone withdrawal and endometrial breakdown and shedding through corticosterone stimulation in mouse menstrual-like model.

Reproduction 2019 Feb;157(2):149-161

Reproductive Physiology Laboratory, National Research Institute for Family Planning, Beijing, China.

Stress impacts the reproductive axis at the level of the hypothalamus and the pituitary gland, which exert an effect on the ovary. Menstruation is regulated by the hypothalamic-pituitary-ovary (HPO) axis. However, the role of stress in menstruation remains unclear. Read More

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https://rep.bioscientifica.com/view/journals/rep/157/2/REP-1
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http://dx.doi.org/10.1530/REP-18-0163DOI Listing
February 2019
2 Reads

Stature-weight growth delays: Clinical and etiological aspects.

J Family Med Prim Care 2018 Sep-Oct;7(5):963-966

Department of Endocrinology, Faculty of Medicine and Pharmacy, Ibn Zohr University, Agadir, Morocco.

Background: Stature-weight growth delay (SWGD) is a frequent motivation of consultation. It could be a consequence of a known chronic affection, congenital or acquired affection. The purpose of this study is to describe epidemiological, clinical, paraclinical, and etiological aspects of SWGD. Read More

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http://dx.doi.org/10.4103/jfmpc.jfmpc_207_16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259559PMC
January 2019

Relevance of Pituitary Gland Magnetic Resonance Imaging Results with Clinical and Laboratory Findings in Growth Hormone Deficiency.

Med Sci Monit 2018 Dec 30;24:9473-9478. Epub 2018 Dec 30.

Department of Pediatric Endocrinology, Ankara Child Disease Hematology Oncology Training and Research Hospital, Ankara, Turkey.

BACKGROUND The present study investigated the relationship between detection of organic pathologies with magnetic resonance imaging of the pituitary gland, clinical and laboratory findings, and treatment response. MATERIAL AND METHODS The study included a total of 183 patients who had isolated growth hormone deficiency, received at least 1 year of treatment, returned regularly for follow-ups, and whose pituitary magnetic resonance images were available. The patients were divided into 2 groups: those with and without pathological evidence with magnetic resonance imaging. Read More

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http://dx.doi.org/10.12659/MSM.911977DOI Listing
December 2018
1 Read

Simpson-Golabi-Behmel syndrome in a 39-year-old male patient with suspected acromegaly-A case study.

Am J Med Genet A 2018 Dec 28. Epub 2018 Dec 28.

Pomeranian Medical University, Department of Endocrinology, Metabolic and Internal Diseases, Szczecin, Poland.

Simpson-Golabi-Behmel syndrome (SGBS) is a rare genetic condition and is inherited in an X-linked recessive manner. The disease is caused by a change in the nucleotide sequence of an X-linked gene encoding glypican 3, a protein belonging to the heparan-sulfate membrane proteoglycan family. SGBS case studies are almost entirely restricted to the pediatric population. Read More

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http://dx.doi.org/10.1002/ajmg.a.61013DOI Listing
December 2018
1 Read

The relation of serum prolactin levels and infection in humans.

Int J Gen Med 2019 20;12:7-12. Epub 2018 Dec 20.

Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran,

Background: is an intracellular protozoan parasite distributed worldwide. Although the infection is benign in immunocompetent individuals, it is life threatening and complicated in immunocompromised patients and fetuses of pregnant women who received their first exposure to during the pregnancy. Prolactin (PRL) is a hormone that is secreted by the pituitary gland, and it is confirmed that it plays a role in the immune system. Read More

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https://www.dovepress.com/the-relation-of-serum-prolactin-le
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http://dx.doi.org/10.2147/IJGM.S188525DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304245PMC
December 2018
12 Reads

Melatonin prevents early pituitary dysfunction induced by sucrose rich diets.

J Pineal Res 2018 Dec 26:e12545. Epub 2018 Dec 26.

Universidad de Buenos Aires. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Centro de Estudios Farmacológicos y Botánicos (CEFYBO), Facultad de Medicina, Buenos Aires, Argentina.

While physiological levels of glucocorticoids are required to ensure proper functions of the body, consistently high levels may engender several deleterious consequences. We have previously shown an increase in the activity of the hypothalamic-pituitary-adrenal (HPA) axis in rats fed sucrose rich diets (SRD). The main goal of this study was to analyze the processes involved in the modulation of the pituitary production of ACTH by SRD, and to test melatonin as a possible therapeutic agent for the prevention of the HPA axis dysfunction. Read More

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http://dx.doi.org/10.1111/jpi.12545DOI Listing
December 2018

A unifying hypothesis for control of body weight and reproduction in seasonally breeding mammals.

J Neuroendocrinol 2018 Dec 26:e12680. Epub 2018 Dec 26.

Rowett Institute of Nutrition and Health, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, UK.

Animals have evolved diverse seasonal variations in physiology and reproduction to accommodate yearly changes in environmental and climatic conditions. These changes in physiology are initiated by changes in photoperiod (daylength) and are mediated through melatonin which relays photoperiodic information to the pars tuberalis of the pituitary gland. Melatonin drives thyroid stimulating hormone transcription and synthesis in the pars tuberalis which in turn regulates thyroid hormone and retinoic acid synthesis in the tanycytes lining the third ventricle of the hypothalamus. Read More

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http://dx.doi.org/10.1111/jne.12680DOI Listing
December 2018
4 Reads

New Molecular Aspects of Cardiac Arrest; Promoting Cardiopulmonary Resuscitation Approaches.

Emerg (Tehran) 2018 2;6(1):e40. Epub 2018 Jul 2.

Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran.

Introduction: Cardiopulmonary resuscitation (CPR) is a method to improve survival of patients with cardiac arrest. This study aimed to identify the key genes affected five minutes after cardiac arrest, hoping to elevate the efficacy of CPR.

Methods: In this bioinformatics study differentially expressed genes of six pigs were downloaded from GEO and screened. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6289159PMC

The pituitary gland prevents shock-associated death by controlling multiple inflammatory mediators.

Biochem Biophys Res Commun 2019 Jan 20;509(1):188-193. Epub 2018 Dec 20.

Pulmonary Center, Department of Medicine, Boston University School of Medicine, Boston, MA, 02118, USA; Center for Thrombosis and Hemostasis, University Medical Center of the Johannes Gutenberg-University, Mainz, Germany. Electronic address:

Bacterial infections cause a major burden of disease worldwide. Sepsis and septic shock are life-threatening complications of infections. The hypothalamic-pituitary-adrenal (HPA) axis initiates the release of endogenous glucocorticoids that modulate the host stress response and acute inflammation during septic shock. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0006291X183275
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http://dx.doi.org/10.1016/j.bbrc.2018.12.101DOI Listing
January 2019
4 Reads

Thyroid stimulating hormone (TSH) autoregulation reduces variation in the TSH response to thyroid hormones.

Temperature (Austin) 2018 8;5(4):380-389. Epub 2018 Oct 8.

School of Mathematical Sciences, ARC Centre of Excellence for Mathematical and Statistical Frontiers, University of Adelaide, Adelaide, Australia.

The physiological functions of Thyroid Stimulating Hormone (TSH) autoregulation, the ultra-short feedback loop inhibition of TSH by TSH itself, have not been determined. In this work we explored the role of TSH autoregulation in thyroid homeostasis. We synthesized the known physiology of autoregulation with theknown physiological relationships between thyroid hormones; in particular between free thyroxine and TSH. Read More

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http://dx.doi.org/10.1080/23328940.2018.1513110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6298488PMC
October 2018

Immunohistochemical detection of prolactin-releasing peptide2 in the brain of the inshore hagfish Eptatretus burgeri.

Gen Comp Endocrinol 2018 Dec 17. Epub 2018 Dec 17.

Laboratory of Integrative Brain Sciences, Department of Biology and Center for Medical Life Science, Waseda University, Tokyo 162-8480, Japan.

Prolactin-releasing peptide2 (PrRP2) belongs to the RFamide peptide group and is a paralog of prolactin-releasing peptide (PrRP). Recent studies demonstrated that PrRP2, but not PrRP, regulates prolactin release in teleosts. The evolutionary origin of PrRP and PrRP2 dates back to at least early vertebrates because homologs of PrRP/PrRP2 were identified in lampreys, one of the earliest branch of vertebrates class Agnatha. Read More

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http://dx.doi.org/10.1016/j.ygcen.2018.12.005DOI Listing
December 2018

Proteomic Analysis of the Human Anterior Pituitary Gland.

OMICS 2018 Dec;22(12):759-769

1 Institute of Bioinformatics, International Technology Park, Bangalore, India.

The pituitary function is regulated by a complex system involving the hypothalamus and biological networks within the pituitary. Although the hormones secreted from the pituitary have been well studied, comprehensive analyses of the pituitary proteome are limited. Pituitary proteomics is a field of postgenomic research that is crucial to understand human health and pituitary diseases. Read More

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https://www.liebertpub.com/doi/10.1089/omi.2018.0160
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http://dx.doi.org/10.1089/omi.2018.0160DOI Listing
December 2018
5 Reads
2.362 Impact Factor

Central diabetes insipidus: beware of Langerhans cell histiocytosis!

Neth J Med 2018 Dec;76(10):445-449

Department of Internal Medicine, Maastricht University Medical Centre, the Netherlands.

Langerhans cell histiocytosis (LCH) is a rare disorder, characterised by a monoclonal proliferation of aberrant histiocytes that accumulate in and infiltrate into different organs. When the hypothalamic-pituitary axis is involved, central diabetes insipidus (CDI) can be its first manifestation. Three cases of LCH with central diabetes insipidus were retrospectively analyzed: Case 1 is a 41-year old female presenting with polyuria and polydipsia. Read More

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December 2018
1 Read

Cyclic Cushing's syndrome caused by neuroendocrine tumor: a case report.

Endocr J 2018 Dec 19. Epub 2018 Dec 19.

Department of Endocrinology, Qilu Hospital of Shandong University, Jinan 250012, China.

Cushing's syndrome (CS) is a clinical syndrome characterized by hypercortisolemia. Cyclic Cushing's syndrome (CCS), which exhibits a periodic or irregular increasing pattern in cortisol, is a rare type of Cushing's syndrome. A 37-year-old man came to our hospital because of repeated dizzy spells, weakness and hypercortisolemia lasting two weeks. Read More

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http://dx.doi.org/10.1507/endocrj.EJ18-0168DOI Listing
December 2018
8 Reads

NPY deficiency prevents postmenopausal adiposity by augmenting estradiol-mediated browning.

J Gerontol A Biol Sci Med Sci 2018 Dec 17. Epub 2018 Dec 17.

Department of Pathology, Nagasaki University School of Medicine, Graduate School of Biomedical Sciences, Nagasaki, Japan.

The orexigenic hormone neuropeptide Y (NPY) plays a pivotal role in the peripheral regulation of fat metabolism. However, the mechanisms underlying the effects of sex on NPY function have not been extensively analyzed. In this study, we examined the effects of NPY deficiency on fat metabolism in male and female mice. Read More

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https://academic.oup.com/biomedgerontology/advance-article/d
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http://dx.doi.org/10.1093/gerona/gly282DOI Listing
December 2018
4 Reads

Pituitary metastasis of breast cancer mimicking IgG4-related hypophysitis.

eNeurologicalSci 2019 Mar 22;14:13-15. Epub 2018 Nov 22.

Department of Neurology, Faculty of Medicine, Fukuoka University, Japan.

IgG4-related hypophysitis, which is the pituitary gland inflammation caused by IgG4 positive lymphocytes, can affect cavernous sinus and orbital apex leading to developing cranial nerve related symptoms such as orbital apex syndrome (OAS). Here we report a case of hypopituitarism associated with OAS caused by pituitary metastasis of the breast cancer with elevated serum IgG4 level, who initially resembled to IgG4-related hypophysitis. Although this case had some features in common with igG4-related hypophysitis. Read More

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http://dx.doi.org/10.1016/j.ensci.2018.11.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6275161PMC

Two Extraordinary Sellar Neuronal Tumors: Literature Review and Comparison of Clinicopathologic Features.

Am J Clin Pathol 2018 Dec 14. Epub 2018 Dec 14.

Department of Pathology, Duke University Medical Center, Durham, NC.

Objectives: The list of tumors involving the pituitary gland has been expanded to include a variety of neuronal and paraneuronal tumors in the 2017 World Health Organization tumor classification of endocrine organs. All the entities included in this category are distinctly rare, with limited case reports in the literature.

Methods: We illustrate two extraordinary sellar tumors with neuronal differentiation: a sellar paraganglioma and a sellar neurocytoma, with thorough literature review and comparison of the clinicopathologic features of these entities. Read More

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http://dx.doi.org/10.1093/ajcp/aqy155DOI Listing
December 2018
1 Read

Hypogonadotropic hypogonadism and pituitary hypoplasia as recurrent features in Ulnar-Mammary syndrome.

Endocr Connect 2018 Dec;7(12):1432-1441

IRCCS Istituto Auxologico Italiano, Service of Medical Genetics, Milan, Italy.

Ulnar-mammary syndrome (UMS) is characterized by ulnar defects, and nipple or apocrine gland hypoplasia, caused by TBX3 haploinsufficiency. Signs of hypogonadism were repeatedly reported, but the mechanisms remain elusive. We aim to assess the origin of hypogonadism in two families with UMS. Read More

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http://dx.doi.org/10.1530/EC-18-0486DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300862PMC
December 2018
1 Read

Cytokines and male infertility.

Eur Cytokine Netw 2018 Sep;29(3):73-82

Unit of Reproductive Endocrinology, First Department of Obstetrics and Gynecology, Medical School, Aristotle University of Thessaloniki, Greece. "Papageorgiou General Hospital", Ring Road-Nea Efkarpia, 56403 Thessaloniki, Greece.

Many male infertility cases have no apparent cause, being characterized as idiopathic. Both inflammation and obesity have long been associated with infertility. On one hand, inflammation, such as orchitis and male accessory gland infections (MAGIs), are regulated by inflammatory cytokines. Read More

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http://www.john-libbey-eurotext.fr/medline.md?doi=10.1684/ec
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http://dx.doi.org/10.1684/ecn.2018.0412DOI Listing
September 2018
9 Reads

Primary hypophysitis and other autoimmune disorders of the sellar and suprasellar regions.

Rev Endocr Metab Disord 2018 Dec 13. Epub 2018 Dec 13.

Medicover GmbH, Berlin/Hannover, Germany.

The pituitary gland and the hypothalamus can be affected by autoimmune-mediated structural and functional disruption. These autoimmune-mediated diseases occur more commonly in females and are often found during pregnancy or in the post-partum period. Autoimmune diseases can either affect parts of the pituitary or hypothalamus, or can involve both sellar and suprasellar structures. Read More

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http://link.springer.com/10.1007/s11154-018-9480-1
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http://dx.doi.org/10.1007/s11154-018-9480-1DOI Listing
December 2018
4 Reads

Hypopituitarism after Gamma Knife surgery for postoperative nonfunctioning pituitary adenoma.

J Neurosurg 2018 Dec;129(Suppl1):47-54

3Department of Neurosurgery.

OBJECTIVEThis study investigated long-term follow-up data on the combined pituitary function test (CPFT) in patients who had undergone transsphenoidal surgery (TSS) for nonfunctioning pituitary adenoma (NFPA) to determine the clinical parameters indicative of hypopituitarism following postoperative Gamma Knife surgery (GKS).METHODSBetween 2001 and 2015, a total of 971 NFPA patients underwent TSS, and 76 of them (7.8%) underwent postoperative GKS. Read More

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http://dx.doi.org/10.3171/2018.7.GKS181589DOI Listing
December 2018
3.737 Impact Factor

Pituitary Metastasis in a Patient with Pulmonary Adenocarcinoma Presenting with a Disturbance of Consciousness.

Klin Onkol 2018 ;31(5):371-375

Background: Brain metastases are one of the main causes of morbidity and mortality of patients with oncological disease. In non-small cell lung carcinoma (NSCLC), the risk of CNS secondary development is 30-50%. An unusual diagnostic and therapeutic problem is the finding of suspicious pituitary lesions. Read More

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http://dx.doi.org/10.14735/amko2018371DOI Listing
January 2018

Activin A in Mammalian Physiology.

Physiol Rev 2019 01;99(1):739-780

Department of Morphology, Universidade Federal de Minas Gerais , Belo Horizonte , Brazil ; Department of Experimental and Clinical Medicine, Università Politecnica delle Marche , Ancona , Italy ; Department of Obstetrics and Gynecology, Universidade Federal de Minas Gerais , Belo Horizonte , Brazil ; Department of Molecular and Developmental Medicine, Obstetrics and Gynecological Clinic, University of Siena , Siena , Italy ; and Department of Biomedical, Experimental and Clinical Sciences, Division of Obstetrics and Gynecology, University of Florence, Careggi University Hospital , Florence , Italy.

Activins are dimeric glycoproteins belonging to the transforming growth factor beta superfamily and resulting from the assembly of two beta subunits, which may also be combined with alpha subunits to form inhibins. Activins were discovered in 1986 following the isolation of inhibins from porcine follicular fluid, and were characterized as ovarian hormones that stimulate follicle stimulating hormone (FSH) release by the pituitary gland. In particular, activin A was shown to be the isoform of greater physiological importance in humans. Read More

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http://dx.doi.org/10.1152/physrev.00002.2018DOI Listing
January 2019
1 Read
27.324 Impact Factor

Hypothyroidism after craniospinal irradiation with proton or photon therapy in patients with medulloblastoma.

Pediatr Hematol Oncol 2018 Dec 11:1-10. Epub 2018 Dec 11.

b Texas Children's Cancer and Hematology Centers , Houston , Texas , USA.

Background: Craniospinal irradiation (CSI) often results in endocrine deficiencies in children with medulloblastoma due to irradiation of the hypothalamic-pituitary axis (HPA) or the thyroid gland. CSI with Proton radiation therapy (PRT) has the potential to decrease the risk of hypothyroidism by reduction in radiation dose to these organs. This study compares the risk for hypothyroidism in patients with medulloblastoma treated with Photon radiation therapy (XRT) or PRT. Read More

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http://dx.doi.org/10.1080/08880018.2018.1471111DOI Listing
December 2018
1 Read

Concurrent pituitary and adrenocortical lesions on computed tomography imaging in dogs with spontaneous hypercortisolism.

J Vet Intern Med 2019 Jan 11;33(1):72-78. Epub 2018 Dec 11.

Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.

Background: Spontaneous hypercortisolism or Cushing's syndrome in dogs is either pituitary or adrenal dependent, but concurrent pituitary and adrenal hypercortisolism also has been reported.

Objective: To determine how often concurrent pituitary and adrenal lesions are present in dogs with spontaneous hypercortisolism.

Animals: Two hundred one client-owned dogs with spontaneous hypercortisolism. Read More

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http://dx.doi.org/10.1111/jvim.15378DOI Listing
January 2019
1 Read

Germline and mosaic mutations causing pituitary tumours: genetic and molecular aspects.

J Endocrinol 2019 Feb;240(2):R21-R45

Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine, Queen Mary University of London, London, UK.

While 95% of pituitary adenomas arise sporadically without a known inheritable predisposing mutation, in about 5% of the cases they can arise in a familial setting, either isolated (familial isolated pituitary adenoma or FIPA) or as part of a syndrome. FIPA is caused, in 15-30% of all kindreds, by inactivating mutations in the AIP gene, encoding a co-chaperone with a vast array of interacting partners and causing most commonly growth hormone excess. While the mechanisms linking AIP with pituitary tumorigenesis have not been fully understood, they are likely to involve several pathways, including the cAMP-dependent protein kinase A pathway via defective G inhibitory protein signalling or altered interaction with phosphodiesterases. Read More

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http://dx.doi.org/10.1530/JOE-18-0446DOI Listing
February 2019
1 Read

Familial ROBO1 deletion associated with ectopic posterior pituitary, duplication of the pituitary stalk and anterior pituitary hypoplasia.

J Pediatr Endocrinol Metab 2018 Dec 11. Epub 2018 Dec 11.

UOC Neurochirurgia, Istituto Giannina Gaslini, Genoa, Italy.

Background The genetic causes of abnormal pituitary development have been extensively studied in the last few years. ROBO1 is involved in neurogenesis and axon guidance. Loss-of-function variants in ROBO1 have been associated with pituitary stalk interruption syndrome (PSIS), suggesting that its haploinsufficiency could impair the guidance of hypothalamic axons to the pituitary gland leading to developmental abnormalities. Read More

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http://dx.doi.org/10.1515/jpem-2018-0272DOI Listing
December 2018

Age related signal changes of the pituitary stalk on thin-slice magnetic resonance imaging in infants.

Brain Dev 2018 Dec 1. Epub 2018 Dec 1.

Department of Radiology, Tokai University School of Medicine, 143 Shimokasuya, Isehara 259-1193, Japan.

Purpose: Signals of some brain regions change along with development in T1-weighted imaging (T1WI) in infants. This study aimed to assess the association of the signal intensity of the pituitary stalk on thin-slice T1WI with infant age.

Methods: This retrospective study was performed in 89 infants (gestational age [GA], 25-41 weeks; postmenstrual age [PMA], 36-46 weeks; chronological age [CA], 4-141 days) without intracranial abnormalities. Read More

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http://dx.doi.org/10.1016/j.braindev.2018.11.009DOI Listing
December 2018
1 Read