77,920 results match your criteria Pituitary Gland


Endometrial adenocarcinoma metastatic to the pituitary gland: a case report and literature review.

J Int Med Res 2020 Jun;48(6):300060520924512

Department of Endocrinology, Liaocheng People's Hospital, Liaocheng, China.

Pituitary metastases are rare, and metastatic pituitary lesions originating from endometrial adenocarcinoma are extremely rare. These lesions can be mistaken for pituitary adenomas and their diagnosis can be very difficult. Pituitary metastases mostly affect the posterior lobe and patients may develop diabetes insipidus. Read More

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http://dx.doi.org/10.1177/0300060520924512DOI Listing

Clinical features and endoscopic findings of granular cell tumor of the sellar region: A case report and review of the literature.

Surg Neurol Int 2020 9;11:101. Epub 2020 May 9.

Departments of Neurosurgery, Ehime University School of Medicine, Shitsukawa, Toon, Ehime, Japan.

Background: Granular cell tumor (GCT) of the sellar region is a rare tumor of the sellar and suprasellar regions that originate from the neurohypophysis. This tumor is very difficult to differentiate from other pituitary neoplasms, such as pituitary adenoma, pituicytoma, and spindle cell oncocytoma. We report a rare case of GCT arising from the posterior pituitary of the sellar region and suggest a useful indicator for accurate diagnosis and pitfalls for surgical procedures. Read More

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http://dx.doi.org/10.25259/SNI_111_2020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7265469PMC

Pituitary adenylate cyclase activating polypeptide concentrations in the sheep mammary gland, milk, and in the lamb blood plasma after suckling.

Physiol Int 2020 Mar;107(1):92-105

6Institute of Animal Science, Faculty of the Agricultural and Food Sciences and Environmental Management, University of Debrecen, Debrecen, Hungary.

Pituitary adenylate cyclase activating polypeptide (PACAP) is involved in development and reproduction. We previously described elevated PACAP levels in the milk compared to the plasma, and the presence of its specific PAC1 receptor in the mammary gland. This study aimed to determine PACAP and vasoactive intestinal peptide (VIP) levels in female suckling lambs compared to ewe plasma and mammary gland, as well as their age-dependent alterations. Read More

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http://dx.doi.org/10.1556/2060.2020.00006DOI Listing

Possible long-term endocrine-metabolic complications in COVID-19: lesson from the SARS model.

Endocrine 2020 Jun 2. Epub 2020 Jun 2.

Department of Clinical and Experimental Medicine, University of Catania, Via S. Sofia 78, 95123, Catania, Italy.

The outbreak of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is centralizing the interest of the scientific world. In the next months, long-term consequences on the endocrine system may arise following COVID-19. In this article, we hypothesized the effects of SARS-CoV-2 taking into account what learned from the severe acute respiratory syndrome coronavirus (SARS-CoV) that caused SARS in 2003. Read More

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http://dx.doi.org/10.1007/s12020-020-02349-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7266418PMC

Rats Lacking Dopamine Transporter Display Increased Vulnerability and Aberrant Autonomic Response to Acute Stress.

Biomolecules 2020 May 31;10(6). Epub 2020 May 31.

Department of Neurology and Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, FL 33136, USA.

The activity of the hypothalamus-pituitary-adrenal (HPA) axis is pivotal in homeostasis and presides the adaptative response to stress. Dopamine Transporter (DAT) plays a key role in the regulation of the HPA axis. We used young adult female DAT Knockout (KO) rats to assess the effects of DAT ablation (partial, heterozygous DAT+/-, or total, homozygous DAT-/-) on vulnerability to stress. Read More

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http://dx.doi.org/10.3390/biom10060842DOI Listing

Obstructive sleep apnea caused by acromegaly: Case report.

Cranio 2020 Jun 2:1-3. Epub 2020 Jun 2.

Department of Oral and Maxillofacial Surgery, Amsterdam UMC and Academic Center for Dentistry Amsterdam (ACTA), University of Amsterdam , Amsterdam, The Netherlands.

Background: Acromegaly is an uncommon syndrome caused by growth hormone-producing pituitary adenoma or pituitary gland hypertrophy. Acromegaly is known to be characterized by progressive somatic disfigurement and a wide range of systematic manifestations. This case study describes a rare case of severe obstructive sleep apnea (OSA) caused by acromegaly. Read More

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http://dx.doi.org/10.1080/08869634.2020.1776530DOI Listing

Primary hypothyroidism with exuberant dermatological manifestations.

An Bras Dermatol 2020 Mar 19. Epub 2020 Mar 19.

Dermatology Service, Hospital Universitário Professor Edgard Santos, Universidade Federal da Bahia, Salvador, BA, Brazil.

Thyroid hormone has effects on the skin. Patients with hypothyroidism have changes such as dry, scaly and rough skin. Increase carotene in the dermis becomes a yellowish tint to the skin of the patient with hypothyroidism. Read More

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http://dx.doi.org/10.1016/j.abd.2019.07.010DOI Listing

Central diabetes insipidus due to sarcoidosis.

Sarcoidosis Vasc Diffuse Lung Dis 2017 28;34(2):191-193. Epub 2017 Apr 28.

Department of Respiratory Medicine, Zuyderland medisch centrum, Heerlen, The Netherlands.

We describe a case of a 40-year old Caucasian male who presented with bihilar enlargement. Additional investigation revealed sarcoidosis. During hospitalization patient developed hypernatremia due to central diabetes insipidus. Read More

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http://dx.doi.org/10.36141/svdld.v34i2.5439DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7170145PMC

Does pituitary compression/empty sella syndrome contribute to MRI-negative Cushing's disease? A single-institution experience.

Neurosurg Focus 2020 Jun;48(6):E3

Departments of1Neurologic Surgery.

Objective: Cushing's disease arises from functioning adrenocorticotropic hormone (ACTH)-secreting pituitary adenomas. These tumors can be very small and evade detection by MRI. Empty sella syndrome is a phenomenon by which an arachnoid outpouching of CSF into the sella leads to compression of the pituitary, likely due to intracranial hypertension (a common issue in Cushing's disease), further leading to difficulty in visualizing the pituitary gland that may contribute to difficulty in finding a tumor on MRI, so-called MRI-negative Cushing's disease. Read More

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http://dx.doi.org/10.3171/2020.3.FOCUS2084DOI Listing

Mammary gland-specific regulation of GNRH and GNRH-receptor gene expression is likely part of a local autoregulatory system in female vizcachas (Rodentia: Chinchillidae).

Gen Comp Endocrinol 2020 May 28:113518. Epub 2020 May 28.

Centro de Estudios Biomédicos, Básicos, Aplicados y Desarrollo (CEBBAD), Argentina; Laboratorio de Neuroendocrinología, Instituto de Biología y Medicina Experimental (IByME)-CONICET, Ciudad Autónoma de Buenos Aires, Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Argentina. Electronic address:

In addition to key mammotrophic hormones such as the pituitary prolactin (PRL) and the ovarian steroids progesterone and estradiol, there are local factors that modulate the tissue dynamics of the mammary glands during pregnancy and lactation. By immunohistochemistry and RT-PCR, we found local transcription and translation of gonadotropin-releasing hormone (GNRH), GNRH receptor (GNRHR), PRL and PRL receptor (PRLR) in mammary glands of adult vizcachas during pregnancy and lactation. Both GNRH and GNRHR showed a lag between protein expression and gene transcription throughout the gestational period: while the highest transcription levels of these genes were recorded at early-pregnancy, the epithelial immunoexpressions of both showed their maximum during lactation. Read More

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http://dx.doi.org/10.1016/j.ygcen.2020.113518DOI Listing

Circadian distribution of autostimulations in rVNS therapy in patients with refractory focal epilepsy.

Epilepsy Behav 2020 May 27;110:107144. Epub 2020 May 27.

Department of Neurosciences and Rehabilitation, Tampere University Hospital, P.O. Box 2000, Tampere FI-33521, Finland; Tampere University, Faculty of Medicine and Health Technology, FI-33014 Tampere, Finland.

Background: Responsive vagus nerve stimulation (rVNS) utilizes an electrocardiograph (ECG)-based algorithm to detect rapid sympathetic activations associated with the onset of a seizure. Abrupt sympathetic activation may also be associated with nocturnal arousals between sleep cycles or transitioning from sleep to wakefulness, a period in which many patients with epilepsy experience seizures. Because of circadian changes in autonomic function, we hypothesized that the autostimulation feature might also behave in a circadian fashion. Read More

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http://dx.doi.org/10.1016/j.yebeh.2020.107144DOI Listing

Coexıstence of Ectopıc Posterıor Pıtuıtary and Sellar/Suprasellar Arachnoıd Cyst: A Case Report.

Curr Med Imaging 2020 May 30. Epub 2020 May 30.

Department of Endocrinology and Metabolic Diseases, Faculty of Medicine, Eskisehir Osmangazi University, Eskisehir. Turkey.

Background: The ectopic posterior pituitary (EPP) is a rare condition characterized by the ectopic location of posterior pituitary lobe associated with varying degree of stalk anomalies. The arachnoid cysts (AC) are benign lesions of the arachnoid, which account for 1% of all intracranial space-occupying lesions. Sellar/suprasellar ACs account for approximately 1% of all ACs. Read More

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http://dx.doi.org/10.2174/1573405616666200530210847DOI Listing

Repeated social defeat promotes persistent inflammatory changes in splenic myeloid cells; decreased expression of β-arrestin-2 (ARRB2) and increased expression of interleukin-6 (IL-6).

BMC Neurosci 2020 May 29;21(1):25. Epub 2020 May 29.

Department of Psychosocial Science, University of Bergen, Bergen, Norway.

Background: Previous studies suggest that persistent exposure to social stress in mammals may be associated with multiple physiological effects. Here, we examine the effects of social stress in rats, i.e. Read More

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http://dx.doi.org/10.1186/s12868-020-00574-4DOI Listing

A curious case of vanishing pituitary adenoma.

Radiol Case Rep 2020 Jul 19;15(7):1050-1053. Epub 2020 May 19.

Department of Radiodiagnosis, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Manipal, Karnataka, India.

Pituitary macroadenoma is the most common suprasellar lesion in adults. If symptomatic, it is managed surgically via transsphenoidal resection. Patients commonly present with headache and visual disturbances. Read More

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http://dx.doi.org/10.1016/j.radcr.2020.04.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240058PMC

Quantitative proteomic analysis of Rett iPSC-derived neuronal progenitors.

Mol Autism 2020 May 27;11(1):38. Epub 2020 May 27.

Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.

Background: Rett syndrome (RTT) is a progressive neurodevelopmental disease that is characterized by abnormalities in cognitive, social, and motor skills. RTT is often caused by mutations in the X-linked gene encoding methyl-CpG binding protein 2 (MeCP2). The mechanism by which impaired MeCP2 induces the pathological abnormalities in the brain is not understood. Read More

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http://dx.doi.org/10.1186/s13229-020-00344-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7251722PMC

Report: central diabetes insipidus and schwannoma in a male with X-linked congenital adrenal hypoplasia.

BMC Endocr Disord 2020 May 27;20(1):73. Epub 2020 May 27.

Department of Pediatrics, Gyeongsang National University School of Medicine, 92 Chilam-dong, Jinju, Gyeongnam, 660-751, South Korea.

Background: DAX1 mutations are related to the X-linked form of adrenal hypoplasia congenita (AHC) in infancy and to hypogonadotropic hypogonadism (HH) in puberty. We report a male patient affected by X-linked AHC who presented with central diabetes insipidus and schwannoma in adulthood, which has not been described in association with AHC.

Case Presentation: A 36-day-old male infant who presented with severe dehydration was admitted to the intensive care unit. Read More

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http://dx.doi.org/10.1186/s12902-020-00553-0DOI Listing

Rathke's cleft-like cysts arise from Isl1 deletion in murine pituitary progenitors.

J Clin Invest 2020 May 26. Epub 2020 May 26.

Department of Human Genetics, University of Michigan Medical Center, Ann Arbor, United States of America.

The transcription factor ISL1 is expressed in pituitary gland stem cells and the thyrotrope and gonadotrope lineages. Pituitary-specific Isl1 deletion causes hypopituitarism with increased stem cell apoptosis, reduced differentiation of thyrotropes and gonadotropes, and reduced body size. Conditional Isl1 deletion causes development of multiple Rathke's cleft-like cysts, with 100% penetrance. Read More

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http://dx.doi.org/10.1172/JCI136745DOI Listing

Gonadotropin Treatment For The Male Hypogonadotropic Hypogonadism.

Curr Pharm Des 2020 May 23. Epub 2020 May 23.

Division of Experimental Oncology/Unit of Urology, URI, IRCCS Ospedale San Raffaele, Milan. Italy.

Hypogonadotropic hypogonadism (HH) is caused by a dysfunction in the hypothalamus and/or the pituitary gland and it can be congenital or acquired. This condition is biochemically characterized by low or inappropriately normal gonadotropins levels along with low total testosterone levels. If fertility is not an issue, testosterone therapy is the treatment of choice to induce and maintain secondary sexual characteristics and sexual function. Read More

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http://dx.doi.org/10.2174/1381612826666200523175806DOI Listing

A novel diagnostic tool for the evaluation of hypothalamic-pituitary region and diagnosis of growth hormone deficiency: pons ratio.

J Pediatr Endocrinol Metab 2020 May 21. Epub 2020 May 21.

Gazi Yasargil Training and Research Hospital Clinics of Paediatric Endocrinology, Diyarbakır, Turkey.

Backgrounds Limitations in the evaluation of the pituitary size and changes according to pubertal status make its validity questionable. Recently, in a small-scale study, pons ratio (PR) has been suggested as a more sensitive tool for diagnosis and etiological evaluation of growth hormone deficiency (GHD). The aim of the study is to evaluate the diagnostic value of PR in the diagnosis of GHD. Read More

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http://dx.doi.org/10.1515/jpem-2019-0321DOI Listing

Assessment of PARP-1 Distribution in Tissues of Cynomolgus Monkeys.

J Histochem Cytochem 2020 Jun 21;68(6):413-435. Epub 2020 May 21.

Department of Molecular Biology, Medical Biochemistry and Pathology, Centre de Recherche sur le Cancer, Laval University, Québec City, QC, Canada.

The poly(ADP-ribose) polymerase 1 (PARP-1) enzyme has received much attention in the last decade due to its promising role in cancer therapeutics. Despite the expanding use of PARP inhibitors in cancer therapy, little is known about PARP-1 tissue distribution. Our study provides a detailed survey of PARP-1 tissue and cellular distribution using well-preserved cynomolgus monkey organs and a well-characterized, highly specific monoclonal PARP-1 antibody. Read More

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http://dx.doi.org/10.1369/0022155420926022DOI Listing

Pharmacological melioration by Selenium on the toxicity of tellurium in neuroendocrine centre (Pituitary Gland) in male wistar rats: A mechanistic approach.

Saudi Pharm J 2020 May 10;28(5):630-636. Epub 2020 Apr 10.

Substance Abuse Research Centre (SARC), College of Pharmacy, Jazan University, Jazan, Saudi Arabia.

Purpose: The present research was designed to evaluate the toxicity of tellurium and its prevention by selenium on the pituitary gland in male Wistar rats.

Methods: 30 rats were used weighing 200-250 gm, and randomly divided them into five groups. Each group contained an equal number of animals. Read More

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http://dx.doi.org/10.1016/j.jsps.2020.04.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229321PMC

The Carbonic Anhydrase Inhibitor Dorzolamide Stimulates the Differentiation of Human Meibomian Gland Epithelial Cells.

Curr Eye Res 2020 May 31:1-7. Epub 2020 May 31.

Schepens Eye Research Institute, Massachusetts Eye and Ear, Harvard Medical School , Boston, Massachusetts, USA.

Purpose Clinical studies have indicated that the long-term use of topical antiglaucoma drugs, such as carbonic anhydrase inhibitors (CAIs), may lead to meibomian gland dysfunction (MGD). We hypothesize that these adverse effects involve a direct influence on human MG epithelial cells (HMGECs). The purpose our present investigation was to test our hypothesis and determine whether exposure to dorzolamide, a CAI, impacts the proliferation, intracellular signaling and differentiation of HMGECs. Read More

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http://dx.doi.org/10.1080/02713683.2020.1772832DOI Listing

The effects of prenatal dexamethasone exposure and fructose challenge on pituitary-adrenocortical activity and anxiety-like behavior in female offspring.

Tissue Cell 2020 Feb 16;62:101309. Epub 2019 Oct 16.

Institute for Biological Research "Siniša Stanković", National Institute of Republic of Serbia, University of Belgrade, 142 despota Stefana Blvd., 11060, Belgrade, Serbia.

Prenatal glucocorticoid overexposure could largely influence pituitary-adrenal activity and anxiety-like behavior in offspring. Our aim was to study the possible potentiating effect of moderate dose of fructose - common ingredient of today's diet - on prenatal glucocorticoid treatment-induced hypothalamo-pituitary-adrenal (HPA) axis changes. Pregnant female rats were treated with multiple dexamethasone (Dx) doses (3 x 0. Read More

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http://dx.doi.org/10.1016/j.tice.2019.101309DOI Listing
February 2020

Pathological and Incidental Findings in 403 Taiwanese Girls With Central Precocious Puberty at Initial Diagnosis.

Front Endocrinol (Lausanne) 2020 5;11:256. Epub 2020 May 5.

Department of Pediatrics, Chang Gung Memorial Hospital, Taoyuan, Taiwan.

Whether girls with central precocious puberty (CPP) should undergo routine brain magnetic resonance imaging (MRI) to identify potential intracranial pathologies is controversial. To evaluate the brain MRI results of girls with CPP and identify the clinical and endocrine predictors of brain abnormalities. This retrospective study obtained data from pediatric endocrine clinics at Chang Gung Children's Hospital. Read More

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http://dx.doi.org/10.3389/fendo.2020.00256DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214687PMC

55-year-old Woman with Headache, Vomiting, and Visual Disturbance.

Clin Pract Cases Emerg Med 2020 May 17;4(2):116-120. Epub 2020 Apr 17.

Rutgers New Jersey Medical School, Department of Emergency Medicine, Newark, New Jersey.

Case Presentation: A 55-year-old woman with a past medical history of hypertension, hyperlipidemia, and iron deficiency anemia presented to the emergency department with three days of headache, nausea, vomiting, and visual changes. Her vital signs were within normal limits. She was noted to have a left cranial nerve six palsy on exam. Read More

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http://dx.doi.org/10.5811/cpcem.2019.12.45546DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7219986PMC

Melatonin and alcohol-related disorders.

Chronobiol Int 2020 May 18:1-23. Epub 2020 May 18.

Department of Zoology and Animal Physiology, Institute of Biology and Earth Sciences, Pomeranian University in Słupsk, Słupsk, Poland.

This review concerns the current knowledge of melatonin and alcohol-related disorders. Chronobiological effects of ethanol are related to melatonin suppression and in relation to inflammation, stress, free radical scavenging, autophagy and cancer risk. It is postulated that both alcohol- and inflammation-induced production of reactive oxygen species (ROS) alters cell membrane properties leading to tissue dysfunction and, subsequent further ROS production. Read More

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http://dx.doi.org/10.1080/07420528.2020.1761372DOI Listing

Aldolase C is a novel molecular marker for folliculo-stellate cells in rodent pituitary.

Cell Tissue Res 2020 May 16. Epub 2020 May 16.

Faculty of Science, Saitama University, Saitama, Japan.

The anterior pituitary gland is composed of five types of hormone-producing cells and folliculo-stellate cells. Folliculo-stellate cells do not produce anterior pituitary hormones but they are thought to play important roles as stem cells, phagocytes, or supporting cells of hormone-producing cells in the anterior pituitary. S100β protein has been used as a folliculo-stellate cell marker in some animals, including rats. Read More

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http://dx.doi.org/10.1007/s00441-020-03200-1DOI Listing

Hypopituitarism in five PROP1 mutation siblings: long-lasting natural course and the effects of growth hormone replacement introduction in middle adulthood.

Pituitary 2020 May 15. Epub 2020 May 15.

Neuroendocrine Department, Clinic for Endocrinology, Diabetes and Metabolic Diseases, Clinical Centre of Serbia, Dr Subotic 13, 11000, Belgrade, Serbia.

Twenty years after the first description of combined hypopituitarism (CPHD) caused by PROP1 mutations, the phenotype of affected subjects is still challenging for clinicians. These patients suffer from pituitary hormone deficits ranging from IGHD to panhypopituitarism. ACTH deficiency usually develops later in life. Read More

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http://dx.doi.org/10.1007/s11102-020-01049-9DOI Listing

Somato-dendritic vasopressin and oxytocin secretion in endocrine and autonomic regulation.

J Neuroendocrinol 2020 Jun 14;32(6):e12856. Epub 2020 May 14.

Neuroscience Institute, Georgia State University, Atlanta, GA, USA.

Somato-dendritic secretion was first demonstrated over 30 years ago. However, although its existence has become widely accepted, the function of somato-dendritic secretion is still not completely understood. Hypothalamic magnocellular neurosecretory cells were among the first neuronal phenotypes in which somato-dendritic secretion was demonstrated and are among the neurones for which the functions of somato-dendritic secretion are best characterised. Read More

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http://dx.doi.org/10.1111/jne.12856DOI Listing

GHRH Antagonists Protect Against Hydrogen Peroxide-Induced Breakdown of Brain Microvascular Endothelium Integrity.

Horm Metab Res 2020 May 13;52(5):336-339. Epub 2020 May 13.

Endocrine, Polypeptide, and Cancer Institute, Veterans Affairs Medical Center, University of Miami, Miami, FL, USA.

Growth hormone releasing hormone is a hypothalamic neuropeptide, which regulates the release of growth hormone from the anterior pituitary gland. Growth hormone releasing hormone antagonists are anticancer agents, associated with strong anti-inflammatory activities. In the present study, we investigated the effects of the GHRH antagonist MIA-602 in the integrity of the brain microvascular endothelium in vitro. Read More

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http://dx.doi.org/10.1055/a-1149-9347DOI Listing

Disrupted hypothalamo-pituitary axis in association with reduced SHH underlies the pathogenesis of NOTCH-deficiency.

J Clin Endocrinol Metab 2020 May 13. Epub 2020 May 13.

Univ Rennes, CNRS, IGDR -Institut de Génétique et Développement de Rennes, Rennes, France.

Context: In human, Sonic Hedgehog, SHH, haploinsufficiency is the predominant cause of holoprosencephaly, a structural malformation of the forebrain midline characterised by phenotypic heterogeneity and incomplete penetrance. The NOTCH signalling pathway has recently been associated with holoprosencephaly, in humans, but the precise mechanism involving NOTCH signalling during early brain development remains unknown.

Objective: The aim of this study was to evaluate the relationship between SHH and NOTCH signalling in order to determine the mechanism by which NOTCH dysfunction could cause midline malformations of the forebrain. Read More

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http://dx.doi.org/10.1210/clinem/dgaa249DOI Listing

Melatonin modulates lactation by regulating prolactin secretion via tuberoinfundibular dopaminergic neurons in Hypothalamus-Pituitary system.

Curr Protein Pept Sci 2020 May 10. Epub 2020 May 10.

State Key Laboratory of Animal Nutrition, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing, 100193. China.

In-depth studies have identified many hormones important for controlling mammary growth and maintaining lactation. One of these is melatonin, which is synthesized and secreted by the pineal gland to regulate circadian rhythms, improve antioxidant capacity, and enhance immunity. Prolactin is secreted by the pituitary gland and is associated with growth and development of mammary glands as well as initiation and maintenance of lactation. Read More

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http://dx.doi.org/10.2174/1389203721666200511093733DOI Listing

Matrix Metalloproteases and Cathepsin D in Human Serum do not Cleave Prolactin to Generate Vasoinhibin.

Clin Lab 2020 May;66(5)

Background: Vasoinhibin is generated in the pituitary gland and in multiple target tissues by proteolytic cleavage of prolactin by matrix metalloproteinases and cathepsin D. A dysregulation of vasoinhibin generation appears to contribute to diabetic retinopathy and diabetic macular edema, retinopathy of prematurity, peripartum cardiomyopathy, and preeclampsia. Here, we investigate whether vasoinhibin is generated by matrix metalloproteinases and cathepsin D in human serum. Read More

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http://dx.doi.org/10.7754/Clin.Lab.2019.191017DOI Listing

Cloning, characterisation and expression profile of kisspeptin1 and the kisspeptin1 receptor in the hypothalamic-pituitary-ovarian axis of Chinese alligator Alligator sinensis during the reproductive cycle.

Reprod Fertil Dev 2020 May;32(8):792-804

Key Laboratory for Conservation and Use of Important Biological Resources of Anhui Province, College of Life Sciences, Anhui Normal University, Wuhu, Anhui 241000, China; and Corresponding author.

Kisspeptin1 (Kiss1), a product of the Kiss1 gene, plays an important role in the regulation of reproduction in vertebrates by activating the Kiss1 receptor (Kiss1R) and its coexpression with gonadotrophin-releasing hormone (GnRH) in GnRH neurons. The purpose of this study was to clone the Kiss1 and Kiss1R genes found in the brain of Alligator sinensis and to explore their relationship with reproduction. The full-length cDNA of Kiss1 is 816bp, the open reading frame (ORF) is 417bp and the gene encodes a 138-amino acid precursor protein. Read More

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http://dx.doi.org/10.1071/RD19332DOI Listing

Pituitary germinomas: a multi-institutional study analyzing patient demographics and management patterns.

Pituitary 2020 May 9. Epub 2020 May 9.

Department of Neurosurgery, University of Illinois at Chicago College of Medicine, 912 S. Wood Street, 4N NPI, Chicago, IL, 60612, USA.

Purpose: Intracranial germinomas are exceedingly rare tumors found in the pineal and suprasellar regions. The extremely low incidence of pituitary germinoma has resulted in a significant gap in knowledge regarding its demographics, management, and treatment outcomes. We present the largest multicenter analysis of pituitary germinomas to date, focused on analyzing demographic and management patterns. Read More

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http://dx.doi.org/10.1007/s11102-020-01042-2DOI Listing

Antiprolactinoma Effect of Hordenine by Inhibiting MAPK Signaling Pathway Activation in Rats.

Evid Based Complement Alternat Med 2020 23;2020:3107290. Epub 2020 Apr 23.

Department of Pharmacy, Tongren Hospital Affiliated to Wuhan University (The Third Hospital of Wuhan), Wuhan, Hubei, China.

Prolactinomas are harmful to human health, and the clinical first-line treatment drug is bromocriptine. However, 20% prolactinomas patients did not respond to bromocriptine. Hordenine is an alkaloid separated from Fructus Hordei Germinatus, which showed significant antihyperprolactinemia activity in rats. Read More

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http://dx.doi.org/10.1155/2020/3107290DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7195642PMC
April 2020
1.880 Impact Factor

Suprasellar pituitary adenomas: a 10-year experience in a single tertiary medical center and a literature review.

Pituitary 2020 May 6. Epub 2020 May 6.

Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, 100730, China.

Background: Suprasellar pituitary adenomas (SPAs) are a special type of pituitary adenoma. Although dozens of SPA cases have been reported, the exact definition and the characteristics of SPA have not been exhaustively discussed before.

Methods: In a retrospective electronic medical records review, 13 patients with SPA were identified in our hospital between January 2010 and December 2019. Read More

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http://dx.doi.org/10.1007/s11102-020-01043-1DOI Listing
May 2020
2.222 Impact Factor

[Testosterone replacement treatment in older people with and without co-morbidities].

Authors:
Michael Zitzmann

Internist (Berl) 2020 Jun;61(6):549-557

Klinische Andrologie, Centrum für Reproduktionsmedizin und Andrologie, Universitätsklinikum Münster, Domagkstr. 11, 48149, Münster, Deutschland.

Testosterone is a natural hormone which is essential to maintaining physical and emotional wellbeing in men, regardless of age. Male hypogonadism is an endocrine condition of testosterone deficiency with the potential to cause multiple morbidities and psychosocial problems. The condition can be of primary (testicular), secondary (hypothalamic-pituitary) or so-called functional origin (as a result of inflammatory conditions, obesity or chronic illness). Read More

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http://dx.doi.org/10.1007/s00108-020-00796-yDOI Listing

ADRENAL INCIDENTALOMA, BREAST CANCER AND UNRECOGNIZED MULTIPLE ENDOCRINE NEOPLASIA TYPE 1.

Authors:
S H Kim J H Park

Acta Endocrinol (Buchar) 2019 Oct-Dec;15(4):513-517

Jeonbuk National University Medical School - Department of Internal Medicine, Jeonju, Republic of Korea.

Background: The incidence of adrenal incidentaloma has been increasing proportional to the use of radiologic examination. Multiple endocrine neoplasia1 (MEN1) syndrome may present with various tumors. The present study reports a case of adrenal incidentaloma with unrecognised MEN1 syndrome associated with breast cancer. Read More

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http://dx.doi.org/10.4183/aeb.2019.513DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7200108PMC

Surgical Indications and Techniques for Adrenalectomy.

Sisli Etfal Hastan Tip Bul 2020 24;54(1):8-22. Epub 2020 Mar 24.

Department of General Surgery, Bahcesehir University Faculty of Medicine, Istanbul, Turkey.

Indications for adrenalectomy are malignancy suspicion or malignant tumors, non-functional tumors with the risk of malignancy and functional adrenal tumors. Regardless of the size of functional tumors, they have surgical indications. The hormone-secreting adrenal tumors in which adrenalectomy is indicated are as follows: Cushing's syndrome, arises from hypersecretion of glucocorticoids produced in fasciculata adrenal cortex, Conn's syndrome, arises from an hypersecretion of aldosterone produced by glomerulosa adrenal cortex, and Pheochromocytomas that arise from adrenal medulla and produce catecholamines. Read More

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http://dx.doi.org/10.14744/SEMB.2019.05578DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7192258PMC

Endocrinological Features of Hartsfield Syndrome in an Adult Patient With a Novel Mutation of .

J Endocr Soc 2020 May 2;4(5):bvaa041. Epub 2020 Apr 2.

Division of Diabetes and Endocrinology, Department of Internal Medicine, Daini Osaka Police Hospital, Karasugatsuji, Ten-noji, Osaka, Japan.

Hartsfield syndrome (HS: OMIM 615465) is a rare congenital disease associated with a mutation of the gene () with the main features of holoprosencephaly and ectrodactyly. Patients with HS also present with endocrinological deficits, such as isolated hypogonadotropic hypogonadism and central diabetes insipidus. Although there are several studies on infancy/childhood history, there is no study of infant/childhood/adolescent/young adult HS natural history and endocrinological findings. Read More

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http://dx.doi.org/10.1210/jendso/bvaa041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7192098PMC

Long noncoding RNA and mRNA profiling of hypothalamic-pituitary-mammary gland axis in lactating sows under heat stress.

Genomics 2020 Apr 28. Epub 2020 Apr 28.

College of Animal Science, Zhejiang University, Hangzhou 310058, China. Electronic address:

Heat stress (HS) seriously affects sow lactation performance and Long non-coding RNAs (lncRNAs) play vital roles in the regulation of transcription and post transcription. However, the mechanism of lncRNAs expression affecting lactation performance on the hypothalamus-pituitary-mammary axis of sows is still unclear. In this study, we performed RNA sequencing and bioinformatics analysis of the hypothalamus, pituitary, and mammary gland tissues of lactating sows under HS and thermal comfort. Read More

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http://dx.doi.org/10.1016/j.ygeno.2020.04.021DOI Listing

Presence of CD3 and CD79a Lymphocytes in the Pituitary Gland of Dogs at Post-mortem Examination.

J Comp Pathol 2020 Apr 29;176:116-121. Epub 2020 Mar 29.

Department of Clinical Sciences, Swedish University of Agricultural Sciences, Uppsala, Sweden. Electronic address:

Hypophysitis has been reported occasionally in dogs, with most cases resembling primary lymphocytic hypophysitis in man. Although it is generally assumed that lymphocytes are not present normally in the canine pituitary gland, few studies have investigated this hypothesis. However, lymphocytes are recognized in the pituitary gland of people and horses without signs of pituitary disease. Read More

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http://dx.doi.org/10.1016/j.jcpa.2020.02.010DOI Listing

Juvenile Nasal Angiofibroma on Ga-DOTANOC PET/CT: Exploring Theranostic Avenues.

Indian J Nucl Med 2020 Apr-Jun;35(2):176-177. Epub 2020 Mar 12.

Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi, India.

Somatostatin (SST) cell surface receptors (SSTRs) are expressed in many different malignant, benign, and neuroendocrine tumors. SSTRs are also expressed in the endothelium of human vessels during angiogenesis and not in the nonproliferating vessels. We present a case of 19-year-old boy with juvenile nasal angiofibroma (JNA), who underwent Ga-DOTANOC PET/CT to explore SSTRs expression and theranostic potential. Read More

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http://dx.doi.org/10.4103/ijnm.IJNM_207_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7182334PMC

Solitary Metastatic Melanoma of the Pituitary Gland: Report of Two Cases and Literature Review.

World Neurosurg 2020 Apr 27;139:378-381. Epub 2020 Apr 27.

Department of Neurosurgery, Fondazione Policlinico Gemelli IRCCS, Università Cattolica del Sacro Cuore - Roma, Rome, Italy.

Background: Pituitary melanoma metastases (PMMs) are extremely rare and only a few cases are reported in the literature. PMMs can grow rapidly and present local invasiveness, leading to acute onset of neurological symptoms such as headache, visual and oculomotion disorders or endocrinological signs such as diabetes insipidus and hypopituitarism, and can be life-threatening. For this reason, PMMs must be recognized and treated promptly. Read More

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http://dx.doi.org/10.1016/j.wneu.2020.04.138DOI Listing

A Moderate Increase in Ambient Temperature Influences The Structure and Hormonal Secretion of Adrenal Glands in Rats.

Cell J 2021 Jan 22;22(4):415-424. Epub 2020 Apr 22.

Department of Cytology, Institute for Biological Research Siniša Stanković, University of Belgrade, 142 Despot Stefan Blvd., Belgrade, Republic of Serbia.

Objective: As a consequence of global warming, the increase in the average annual temperature is observed, while the living organisms actively adapt to these changes. High environmental temperature initiates numerous physiological, autonomic, and behavioral responses, and activates the stress response. Thus, the aim of the study was to investigate effect of a moderate increase in ambient temperature on the activity of the hypothalamic-pituitary-adrenocortical (HPA) axis by determining histological changes in adrenal glands and hormonal levels in adult male rats. Read More

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http://dx.doi.org/10.22074/cellj.2021.6827DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7211272PMC
January 2021

COVID-19, hypothalamo-pituitary-adrenal axis and clinical implications.

Authors:
Rimesh Pal

Endocrine 2020 May 28;68(2):251-252. Epub 2020 Apr 28.

Post Graduate Institute of Medical Education and Research, Chandigarh, 160012, India.

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http://dx.doi.org/10.1007/s12020-020-02325-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7186765PMC

Hormonal and molecular alterations induced by sub-lethal toxicity of zinc oxide nanoparticles on .

Saudi J Biol Sci 2020 May 16;27(5):1296-1301. Epub 2020 Jan 16.

Department of Biological Sciences, Faculty of Science, King Abdulaziz University, P.O. Box 80203, Jeddah 21589, Saudi Arabia.

This study was carried out to determine the biochemical and molecular potential effects of Zn-ONPs sub-lethal toxicity on the hormonal profile of (O. niloticus). One hundred and fifty juvenile female were used in this experiment; Ninety for determination of LC50 and other 60 fish were divided into 3 groups with 20 fish each (two replicate in each group). Read More

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http://dx.doi.org/10.1016/j.sjbs.2020.01.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7182787PMC