4,798 results match your criteria Pituitary Disease and Pregnancy


Plurihormonal Pituitary Tumor of Pit-1 and SF-1 Lineages, with Synchronous Collision Corticotroph Tumor: a Possible Stem Cell Phenomenon.

Endocr Pathol 2019 Jan 4. Epub 2019 Jan 4.

Department of Pathology, Laboratory Medicine Program, University Health Network, Toronto, Ontario, Canada.

Thyrotropin (TSH)-secreting pituitary tumors are the rarest functioning pituitary tumors. Nonetheless, they are not infrequently plurihormonal, as they may express/secrete hormones made by other pituitary cells derived from the Pit-1 lineage such as growth hormone (GH), prolactin (PRL), and α-subunit (αSU). However, adrenocorticotropin (ACTH) or gonadotropin secretion by such a tumor is exceptional. Read More

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http://dx.doi.org/10.1007/s12022-018-9562-3DOI Listing
January 2019
1 Read

Gestational Stress Augments Postpartum β-Amyloid Pathology and Cognitive Decline in a Mouse Model of Alzheimer's Disease.

Cereb Cortex 2018 Oct 1. Epub 2018 Oct 1.

Department of Neuroscience, Canadian Centre for Behavioural Neuroscience (CCBN), University of Lethbridge, Lethbridge, AB, Canada.

Besides well-known risk factors for Alzheimer's disease (AD), stress, and in particular noise stress (NS), is a lifestyle risk factor common today. It is known that females are at a significantly greater risk of developing AD than males, and given that stress is a common adversity in females during pregnancy, we hypothesized that gestational noise exposure could exacerbate the postpartum development of the AD-like neuropathological changes during the life span. Pregnant APPNL-G-F/NL-G-F mice were randomly assigned to either the stress condition or control group. Read More

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http://dx.doi.org/10.1093/cercor/bhy251DOI Listing
October 2018

Primary hypophysitis and other autoimmune disorders of the sellar and suprasellar regions.

Rev Endocr Metab Disord 2018 Dec 13. Epub 2018 Dec 13.

Medicover GmbH, Berlin/Hannover, Germany.

The pituitary gland and the hypothalamus can be affected by autoimmune-mediated structural and functional disruption. These autoimmune-mediated diseases occur more commonly in females and are often found during pregnancy or in the post-partum period. Autoimmune diseases can either affect parts of the pituitary or hypothalamus, or can involve both sellar and suprasellar structures. Read More

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http://link.springer.com/10.1007/s11154-018-9480-1
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http://dx.doi.org/10.1007/s11154-018-9480-1DOI Listing
December 2018
4 Reads

Maternal high fat diet programs hypothalamic-pituitary-adrenal function in adult rat offspring.

Psychoneuroendocrinology 2018 Dec 6;102:128-138. Epub 2018 Dec 6.

Department of Neurology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China. Electronic address:

Maternal environmental factors such as diet have profound effects on offspring development and later health. The hypothalamic-pituitary-adrenal (HPA) axis is an important stress neuroendocrine system that is subject to programming by early life challenges. The present study was further to investigate whether maternal high fat diet (HFD) exposure during rat pregnancy and lactation can alter the HPA axis activity in adult male offspring. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03064530183100
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http://dx.doi.org/10.1016/j.psyneuen.2018.12.003DOI Listing
December 2018
3 Reads

hCG production by mucinous adenocarcinoma of the ovary in a reproductive aged woman.

Gynecol Oncol Rep 2018 Nov 31;26:102-104. Epub 2018 Oct 31.

Division of Gynecologic Oncology, The University of Iowa Hospitals and Clinics, United States.

When elevated serum hCG is discovered during the work up of a gynecologic tumor, it is paramount to identify the source of hCG prior to initiation of treatment. Potential sources of hCG include viable intrauterine pregnancy, ectopic pregnancy, miscarriage, gestational trophoblastic disease, pituitary hCG production, phantom hCG (heterophilic antibody interference), and tumor production. Here, we present a case of elevated hCG in a young women with a large complex pelvic mass. Read More

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http://dx.doi.org/10.1016/j.gore.2018.10.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6258238PMC
November 2018
2 Reads

Neuro-Ophthalmic Disorders in Pregnancy.

Neurol Clin 2019 Feb;37(1):85-102

Department of Neurology, Brigham and Women's Hospital, 60 Fenwood Road, Boston, MA 02115, USA; Department of Ophthalmology, Massachusetts Eye and Ear, 243 Charles Street, Boston, MA 02114, USA. Electronic address:

The physiologic changes that accompany pregnancy can have important implications for neuro-ophthalmic disease. This article discusses pregnancy-related considerations for meningioma, pituitary disorders, demyelinating disease, myasthenia gravis, thyroid eye disease, idiopathic intracranial hypertension, cerebral venous sinus thrombosis, stroke, migraine, and cranial neuropathies. The article also details the potential neuro-ophthalmic complications of preeclampsia and eclampsia and reviews the use of common diagnostic studies during pregnancy. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07338619183125
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http://dx.doi.org/10.1016/j.ncl.2018.09.001DOI Listing
February 2019
6 Reads

No evidence of adverse fertility and pregnancy outcomes in patients with unrecognized and untreated multiple endocrine neoplasia type 1.

Clin Endocrinol (Oxf) 2018 Oct 28. Epub 2018 Oct 28.

School of Medicine, Department of Diabetes and Endocrinology, Royal Hobart Hospital, University of Tasmania, Hobart, Tasmania.

Objective: Literature concerning the impact of multiple endocrine neoplasia type 1 (MEN 1) on fertility is limited to case reports despite the early onset of endocrinopathies, such as primary hyperparathyroidism and prolactinoma, that may impact fertility. This study describes the impact of unrecognized and untreated MEN 1 on fertility and pregnancy outcomes in a multigenerational cohort of the Tasman 1 MEN 1 kindred.

Methods: All MEN 1 positive (MEN 1 , n = 63) and MEN 1 negative (MEN 1 , n = 75) descendants born between 1825 and 1951 of a common founder. Read More

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http://doi.wiley.com/10.1111/cen.13890
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http://dx.doi.org/10.1111/cen.13890DOI Listing
October 2018
7 Reads

Surgery for Cushing's disease in pregnancy: our experience and a literature review.

Ann R Coll Surg Engl 2019 Jan 5;101(1):e26-e31. Epub 2018 Oct 5.

Department of Endocrinology, University Hospital Birmingham , Birmingham , UK.

Cushing's syndrome in pregnancy is a rare phenomenon and there is limited literature on its management. Cushing's disease in pregnancy is even less common and there is little guidance to help in the treatment for this patient group. Diagnosis of Cushing's syndrome in pregnancy is often delayed due to overlap of symptoms. Read More

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http://dx.doi.org/10.1308/rcsann.2018.0175DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303815PMC
January 2019
10 Reads

The gonadotropin system, lessons from animal models and clinical cases.

Minerva Ginecol 2018 Oct 26;70(5):561-587. Epub 2018 Sep 26.

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This review article centers upon family of gonadotropin hormones which consists of two pituitary hormones - follicle-stimulating hormone (FSH) and luteinizing hormone (LH) as well as one non-pituitary hormone - human chorionic gonadotropin (hCG) secreted by placenta, and their receptors. Gonadotropins play an essential role in proper sexual development, puberty, gametogenesis, maintenance of pregnancy and male sexual differentiation during the fetal development. They belong to the family of glycoprotein hormones thus they constitute heterodimeric proteins built of common α subunit and hormone-specific β-subunit. Read More

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http://dx.doi.org/10.23736/S0026-4784.18.04307-1DOI Listing
October 2018
2 Reads

Pregnancy-associated Cushing's disease? An exploratory retrospective study.

Pituitary 2018 Sep 14. Epub 2018 Sep 14.

Pacific Neuroscience Institute, John Wayne Cancer Institute at Providence's Saint John's Health Center, 2125 Arizona Ave., Santa Monica, CA, 90404, USA.

Purpose: In most clinical series of Cushing's disease (CD), over 80% of patients are women, many of whom are of reproductive age. The year following pregnancy may be a common time to develop CD. We sought to establish the incidence of CD onset associated with pregnancy. Read More

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http://dx.doi.org/10.1007/s11102-018-0910-6DOI Listing
September 2018
2 Reads

Neurosurgical anesthesia for a pregnant woman with macroprolactinoma: A case report.

Medicine (Baltimore) 2018 Sep;97(37):e12360

Department of Anesthesiology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, People's Republic of China.

Rationale: Being required to perform neurosurgery on a pregnant woman is rare, but occasionally unavoidable. In these cases, clinical anesthesiologists are confronted with conflicting information and few evidence-based guidelines.

Patient Concerns: Here, we describe the successful anesthetic management of a 24-week pregnant woman with macroprolactinoma who underwent endonasal transsphenoidal resection of pituitary adenoma. Read More

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http://dx.doi.org/10.1097/MD.0000000000012360DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156042PMC
September 2018
3 Reads

Beat the giant: case of a giant prolactinoma during pregnancy on cabergoline.

Endocrinol Diabetes Metab Case Rep 2018 23;2018. Epub 2018 Aug 23.

Obesity, Endocrine, and Metabolism Center, King Fahad Medical City, Riyadh, Saudi Arabia.

Giant prolactinomas are a rare entity; during pregnancy, the risk for complications associated with these tumors is higher. Here, we report a case of a young woman who had an invasive, giant prolactinoma post resection with residual disease who became pregnant. This patient was treated with cabergoline to prevent tumor expansion in pregnancy, resulting in the uneventful delivery of a healthy baby boy. Read More

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https://edm.bioscientifica.com/view/journals/edm/2018/1/EDM1
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http://dx.doi.org/10.1530/EDM-18-0099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109208PMC
August 2018
11 Reads

Diabetes Insipidus Presenting with Oligohydramnios and Polyuria During Pregnancy.

J Nippon Med Sch 2018 ;85(3):191-193

Department of Internal Medicine, Chonnam National University Medical School.

We report a case of subclinical central diabetes insipidus (DI), due to Rathke's cleft cysts, that was initially misdiagnosed as transient DI of pregnancy because it presented in the third trimester of pregnancy. A 37-year-old primigravida visited the Department of Obstetrics in the 30th week of gestation due to polyuria. She was admitted due to oligohydramnios; the amniotic fluid index was 3. Read More

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https://www.jstage.jst.go.jp/article/jnms/85/3/85_JNMS.2018_
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http://dx.doi.org/10.1272/jnms.JNMS.2018_85-29DOI Listing
October 2018
15 Reads

Inoperable Giant Growth Hormone-secreting Pituitary Adenoma: Radiological Aspects, Clinical Management and Pregnancy Outcome.

Endocr Metab Immune Disord Drug Targets 2018 Aug 7. Epub 2018 Aug 7.

Interdisciplinary Department of Medicine, Section of Internal Medicine, Geriatrics, Endocrinology & Rare Diseases, University of Bari "Aldo Moro", Bari. Italy.

Background And Objective: giant pituitary adenomas (GPAs) are benign tumours with a diameter ≥ 4 cm [1]. They can cause symptoms and signs due to the possible hyper-secretion of one or more pituitary hormones, and involvement of the surrounding structures whereas the compression of the pituitary itself can lead to hypopituitarism.

Methods: we report on a young woman with acromegaly due to an inoperable giant GH-secreting pituitary adenoma extending to right cavernous sinus, right orbital cavity, ethmoid, right maxillary sinus, sphenoid sinus, clivus and right temporal fossa, in which medical treatment with Octreotide-LAR was able to promptly relieve headache and bilateral hemianopsia due to optic chiasm involvement, improve acromegaly symptoms and, over the time, control tumor expansion, improving fertility and therefore allowing the patient to become pregnant. Read More

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http://dx.doi.org/10.2174/1871530318666180807160712DOI Listing
August 2018
11 Reads

Programming Bugs: Microbiota and the Developmental Origins of Brain Health and Disease.

Biol Psychiatry 2019 Jan 27;85(2):150-163. Epub 2018 Jun 27.

APC Microbiome Ireland, University College Cork, Cork, Ireland; Department of Anatomy and Neuroscience, University College Cork, Cork, Ireland. Electronic address:

It has been nearly 30 years since Dr. David Barker first highlighted the importance of prenatal factors in contributing to the developmental origins of adult disease. This concept was later broadened to include postnatal events. Read More

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http://dx.doi.org/10.1016/j.biopsych.2018.06.014DOI Listing
January 2019
12 Reads

Developmental origins of the human hypothalamic-pituitary-adrenal axis.

Expert Rev Endocrinol Metab 2017 09 2;12(5):321-339. Epub 2017 Aug 2.

a Department of Psychiatry and Human Behavior , University of California , Irvine , CA , USA.

Introduction: The developmental origins of disease or fetal programming model predicts that intrauterine exposures have life long consequences for physical and psychological health. Prenatal programming of the fetal hypothalamic-pituitary-adrenal (HPA) axis is proposed as a primary mechanism by which early experiences are linked to later disease risk. Areas covered: This review describes the development of the fetal HPA axis, which is determined by an intricately timed cascade of endocrine events during gestation and is regulated by an integrated maternal-placental-fetal steroidogenic unit. Read More

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http://dx.doi.org/10.1080/17446651.2017.1356222DOI Listing
September 2017
2 Reads

Metabolic Syndrome in Hyperprolactinemia.

Front Horm Res 2018 5;49:29-47. Epub 2018 Apr 5.

The metabolic syndrome (MetS) is a conglomerate of clinical findings that convey into increased morbidity and mortality from type 2 diabetes mellitus (T2D) and cardiovascular disease. Hyperprolactinemia (hyperPRL) is associated with components of MetS, especially during pregnancy. Endogenous levels of sex steroids are high during pregnancy in contrast to untreated or replaced hypogonadism in most patients with a prolactinoma and hypogonadism may confer increased risk of MetS in hyperPRL. Read More

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http://dx.doi.org/10.1159/000486000DOI Listing
January 2019
4 Reads

Early-Life Stress: From Neuroendocrine Mechanisms to Stress-Related Disorders.

Horm Res Paediatr 2018 8;89(5):372-379. Epub 2018 Jun 8.

Stress exposure is highly prevalent in the general population; however, the experience of stress during vulnerable periods of development has substantial and permanent effects on brain structure and function and physical health in adulthood. Stress, the state of threatened homeostasis, is generally associated with a time-limited activation of the stress system, i.e. Read More

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http://dx.doi.org/10.1159/000488468DOI Listing
October 2018
11 Reads

An Ω-3 fatty acid-deficient diet during gestation induces depressive-like behavior in rats: the role of the hypothalamo-pituitary-adrenal (HPA) system.

Food Funct 2018 Jun;9(6):3481-3488

Institute of Clinical Pharmacy & Pharmacology, Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, PR China.

Low intake of omega-3 (Ω-3) polyunsaturated fatty acids (PUFAs) especially docosahexaenoic acid (DHA) is associated with postpartum depression. DHA deficiency is accompanied by impaired attention and cognition, and will precipitate psychiatric symptoms. However, the effects of dietary DHA on postpartum depression remain unclear. Read More

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http://dx.doi.org/10.1039/c7fo01714fDOI Listing
June 2018
6 Reads

MECHANISMS IN ENDOCRINOLOGY: Hypophysitis: diagnosis and treatment.

Eur J Endocrinol 2018 Sep 7;179(3):R151-R163. Epub 2018 Jun 7.

Department of EndocrinologyGuy's & St. Thomas' NHS Foundation Trust, London, UK

Hypophysitis is a rare condition characterised by inflammation of the pituitary gland, usually resulting in hypopituitarism and pituitary enlargement. Pituitary inflammation can occur as a primary hypophysitis (most commonly lymphocytic, granulomatous or xanthomatous disease) or as secondary hypophysitis (as a result of systemic diseases, immunotherapy or alternative sella-based pathologies). Hypophysitis can be classified using anatomical, histopathological and aetiological criteria. Read More

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http://dx.doi.org/10.1530/EJE-17-0009DOI Listing
September 2018
2 Reads

Developed diplopia due to a pituitary macroadenoma during pregnancy.

Pan Afr Med J 2018 17;29:39. Epub 2018 Jan 17.

Department of Endocrinology, National Institute of Nutrition, Tunis, Tunisia.

Physiologic pituitary enlargement is common during normal pregnancy. However, symptoms such as diplopia, blurred vision and headache resulting from physiologic pituitary enlargement are very rare during pregnancy. A 43-year-old woman complained of sudden headache and left eye ptosis at 36th weeks of gestation. Read More

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http://dx.doi.org/10.11604/pamj.2018.29.39.12706DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987105PMC
June 2018
7 Reads

The Hypothalamic-Pituitary-Adrenal Axis and the Fetus.

Horm Res Paediatr 2018 6;89(5):380-387. Epub 2018 Jun 6.

Division of Pediatric Endocrinology, Department of Pediatrics, Children's Hospital of Pittsburgh of UPMC, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

Glucocorticoids (GCs), cortisol in humans, influence multiple essential maturational events during gestation. In the human fetus, fetal hypothalamic-pituitary-adrenal (HPA) axis function, fetal adrenal steroidogenesis, placental 11β- hydroxysteroid dehydrogenase type 2 activity, maternal cortisol concentrations, and environmental factors impact fetal cortisol exposure. The beneficial effects of synthetic glucocorticoids (sGCs), such as dexamethasone and betamethasone, on fetal lung maturation have significantly shifted the management of preterm labor and threatened preterm birth. Read More

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http://dx.doi.org/10.1159/000488106DOI Listing
October 2018
2 Reads

Maternal hypothalamus-pituitary-adrenal (HPA) system activity and stress during pregnancy: Effects on gestational age and infant's anthropometric measures at birth.

Psychoneuroendocrinology 2018 Aug 22;94:152-161. Epub 2018 Apr 22.

Department of Psychiatry and Psychotherapy, RG Stress, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Germany.

Background: Prenatal maternal stress might be a risk for the developing fetus and may have long-lasting effects on child and adult vulnerability to somatic and psychiatric disease. Over-exposure of the unborn to excess glucocorticoids and subsequent alteration of fetal development is hypothesized to be one of the key mechanisms linking prenatal stress with negative child outcome.

Methods: In this prospective longitudinal study, mothers-to-be (n = 405) in late pregnancy (36. Read More

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http://dx.doi.org/10.1016/j.psyneuen.2018.04.022DOI Listing
August 2018
3 Reads

Peripartum cardiomyopathy.

Herz 2018 May 16. Epub 2018 May 16.

Department of Cardiology and Angiology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.

Peripartum cardiomyopathy (PPCM) is a rare and potentially life-threatening disease that occurs toward the end of pregnancy or in the months following delivery in previously heart-healthy women. The incidence varies widely depending on geographical region and ethnic background, with an estimated number of 1 in 1000-1500 pregnancies in Germany. The course of the disease ranges from mild forms with minor symptoms to severe forms with acute heart failure and cardiogenic shock. Read More

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http://link.springer.com/10.1007/s00059-018-4709-z
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http://dx.doi.org/10.1007/s00059-018-4709-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6096623PMC
May 2018
3 Reads

Pregnancy in Patients with Cushing's Syndrome.

Endocrinol Metab Clin North Am 2018 06;47(2):441-449

Neuroendocrine Unit, Division of Endocrinology and Metabolism, Hospital das Clínicas, University of São Paulo Medical School, Avenida Enéas de Carvalho Aguiar, n° 155, 8° andar, bloco 03, São Paulo, São Paulo 05403-000, Brazil. Electronic address:

Progress in diagnosis and treatment of endocrine diseases has made pregnancy possible for women with endocrinopathies, including Cushing's syndrome (CS). The risk of maternal-fetal complications in patients who are not biochemically controlled, however, is substantial. Therefore, the surgical and/or medical control of hypercortisolism is mandatory prior to conceiving. Read More

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http://dx.doi.org/10.1016/j.ecl.2018.02.004DOI Listing
June 2018
2 Reads

Gestational Hypoxia and Developmental Plasticity.

Physiol Rev 2018 07;98(3):1241-1334

The Lawrence D. Longo, MD Center for Perinatal Biology, Department of Basic Sciences, Loma Linda University School of Medicine , Loma Linda, California.

Hypoxia is one of the most common and severe challenges to the maintenance of homeostasis. Oxygen sensing is a property of all tissues, and the response to hypoxia is multidimensional involving complicated intracellular networks concerned with the transduction of hypoxia-induced responses. Of all the stresses to which the fetus and newborn infant are subjected, perhaps the most important and clinically relevant is that of hypoxia. Read More

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http://dx.doi.org/10.1152/physrev.00043.2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6088145PMC

Reproduction in domestic ruminants during the past 50 yr: discovery to application.

J Anim Sci 2018 Jun;96(7):2952-2970

Department of Animal Science, University of Wisconsin, Madison, WI.

The study of reproductive physiology in domestic ruminants has progressed from the whole animal to the molecular level in an amazingly short period of time. The volume of information on this subject is enormous; therefore, we have focused on domestic ruminants, with an emphasis on cattle. To date, artificial insemination (AI) is perhaps the most powerful technique that reproductive physiologists and geneticists have provided the livestock industry for genetic improvement. Read More

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http://dx.doi.org/10.1093/jas/sky139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6095338PMC
June 2018
16 Reads

[GESTASTRES cohort study protocol on the effects of stress during pregnancy by measuring the cortisol in women's and newborn's hair].

Rev Esp Salud Publica 2018 Apr 16;92. Epub 2018 Apr 16.

Centro de Investigación Mente, Cerebro y Comportamiento (CIMCYC), Universidad de Granada. Granada. España.

The aim was to present the longitudinal study protocol on the effects of perinatal stress from conception to one year of age. Stress is associated to psychopathological, cardiovascular and inmunological diseases. During pregnancy, the activation of the Hipotalamic-Pituitary-Adrenal results in an increased release of cortisol. Read More

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April 2018
1 Read

Evaluation and Management of Children with Thyrotoxicosis.

Recent Pat Endocr Metab Immune Drug Discov 2017 ;11(1):22-31

Departments of Medicine, Community Health Sciences, and Oncology, The University of Calgary, Calgary, Alberta, Canada.

Background: Uncontrolled thyrotoxicosis, especially in early infancy, may cause irreversible damage to the central nervous system as well as profound effects on the function of many organs. Thyrotoxicosis has multiple etiologies and treatment depends on the underlying etiology. An accurate diagnosis is essential so that appropriate treatment can be initiated without undue delay. Read More

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http://dx.doi.org/10.2174/1872214812666180327112540DOI Listing
October 2018
6 Reads

Central congenital hypothyroidism caused by maternal thyrotoxicosis.

BMJ Case Rep 2018 Mar 22;2018. Epub 2018 Mar 22.

Department of Pediatrics, Haga Hospital/Juliana Children's Hospital, The Hague, Netherlands.

Central congenital hypothyroidism (CCH) is a rare and underdiagnosed disease that sometimes is caused by maternal Graves' disease. We report a case of CCH caused by undiagnosed, initially antibody-negative maternal thyrotoxicosis with possible disruption of fetal hypothalamic-pituitary-thyroid axis maturation. In CCH, maternal thyroid disease should be considered. Read More

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http://dx.doi.org/10.1136/bcr-2017-222620DOI Listing
March 2018
3 Reads

Pituitary disease management during pregnancy: an overview.

Minerva Endocrinol 2018 Dec 15;43(4):420-422. Epub 2018 Mar 15.

ENDOC Center for Endocrine Tumors, Hamburg, Germany -

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https://www.minervamedica.it/index2.php?show=R07Y2018N04A042
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http://dx.doi.org/10.23736/S0391-1977.18.02835-3DOI Listing
December 2018
1 Read

The Ovarian Cycle.

Vitam Horm 2018 23;107:1-25. Epub 2018 Feb 23.

Baylor College of Medicine, Houston, TX, United States; Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX, United States; Center for Reproductive Medicine, Baylor College of Medicine, Houston, TX, United States. Electronic address:

The "ovarian cycle" is an exquisite and dynamic endocrine system that includes ovarian events, hypothalamic-pituitary interactions, uterine endometrial and myometrial changes during implantation and pregnancy, cervical alterations in structure, and breast development. The ovarian cycle and the steroid hormones produced by the ovary also impact epithelial cancer development in the ovary, uterus, cervix, and breast. This chapter provides a personal view of recent developments that occur in this complex endocrine environment. Read More

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http://dx.doi.org/10.1016/bs.vh.2018.01.009DOI Listing
November 2018

Novel hGHRH homodimer promotes fertility of female infertile hamster by up-regulating ovarian GHRH receptor without triggering GH secretion.

Eur J Pharm Sci 2018 May 8;117:341-350. Epub 2018 Mar 8.

Department of Biochemistry and Molecular Biology, School of Basic Courses, Guangdong Pharmaceutical University, Guangzhou 510006, China. Electronic address:

Extra-hypothalamic growth hormone-releasing hormone (GHRH) plays an important role in infertility. The female infertility models were formed by intraperitoneally injecting cyclophosphamide in 5-week-old Chinese hamster once in a week for 5 weeks. All the models mated with healthy male hamster in the ratio of 1:1 in the experimental 6-8th week and the couples were separated to breed in the 9-10th week. Read More

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http://dx.doi.org/10.1016/j.ejps.2018.03.012DOI Listing
May 2018
32 Reads

MANAGEMENT OF ENDOCRINE DISEASE: Management of Cushing's syndrome during pregnancy: solved and unsolved questions.

Eur J Endocrinol 2018 Jun 9;178(6):R259-R266. Epub 2018 Mar 9.

Aix-Marseille Université, Institut National de la Santé et de la Recherche Médicale (INSERM), U1251, Marseille Medical Genetics, Marseille, France.

With fewer than 200 reported cases, Cushing's syndrome (CS) in pregnancy remains a diagnostic and therapeutic challenge. In normal pregnancies, misleading signs may be observed such as striae or hypokalemia, while plasma cortisol and urinary free cortisol may rise up to 2- to 3-fold. While the dexamethasone suppression test is difficult to use, reference values for salivary cortisol appear valid. Read More

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http://dx.doi.org/10.1530/EJE-17-1058DOI Listing
June 2018
15 Reads

Case report of a pituitary thyrotropin-secreting macroadenoma with Hashimoto thyroiditis and infertility.

Medicine (Baltimore) 2018 Jan;97(1):e9546

Department of Endocrinology and Metabolism.

Rationale: Thyrotropin-secreting adenoma (TSHoma) is rare, diagnosis and treatment are often delayed if the condition coexists with Hashimoto thyroiditis. The enlarged pituitary adenoma may eventually induce panhypopituitarism, infertility, or the compression of optic nerves and optic chiasma.

Patient Concerns: This patient was a 36-year-old man who had been referred to the pituitary disease multidisciplinary team (MDT) of the West China Hospital, due to infertility. Read More

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http://Insights.ovid.com/crossref?an=00005792-201801050-0002
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http://dx.doi.org/10.1097/MD.0000000000009546DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5943133PMC
January 2018
9 Reads

Acute pituitary disease in pregnancy: how to handle hypophysitis and Sheehan's syndrome.

Minerva Endocrinol 2018 Dec 19;43(4):465-475. Epub 2018 Feb 19.

Department of Neurosurgery, University of Tübingen, Tübingen, Germany.

Pregnancy-related hypophysitis (PR-Hy) that typically occurs during late pregnancy and the early postpartum period is considered an autoimmune disorder. Knowledge and awareness of characteristic clinical symptoms and specific endocrine and neuroradiological features mostly enables a correct diagnosis and guarantees best possible management. In the presence of mild clinical symptoms, a "wait-and-watch" approach is recommended. Read More

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http://dx.doi.org/10.23736/S0391-1977.18.02814-6DOI Listing
December 2018
1 Read

Management of Skull Base Tumors in the Obstetric Population: A Case Series.

World Neurosurg 2018 May 14;113:e373-e382. Epub 2018 Feb 14.

Department of Neurological Surgery, Wexner Medical Center, The Ohio State University, Columbus, Ohio, USA; Department of Otolaryngology Head and Neck Surgery, Wexner Medical Center, The Ohio State University, Columbus, Ohio, USA. Electronic address:

Background: Neoplasms rarely present during pregnancy; however, increases in plasma volume, hormone release-induced growth, and tumor hypervascularity can cause rapidly progressive symptoms of varying severity, ranging from those not requiring intervention to those necessitating emergent operations. Here we describe an algorithm for the management of symptomatic neoplasms in the obstetric population and provide recommendations for surgical indications and timing.

Methods: Patients who presented to the skull base clinic at a large tertiary care hospital between 2010 and 2016 were reviewed to identify those who presented with a skull base tumor during pregnancy. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.02.038DOI Listing
May 2018
4 Reads

Cushing's disease: major difficulties in diagnosis and management during pregnancy.

Minerva Endocrinol 2018 Dec 13;43(4):435-445. Epub 2018 Feb 13.

Department of Endocrinology, Sant Pau Hospital, Barcelona, Spain -

Pregnancy in women with a diagnosis of Cushing' syndrome (CS) is an extremely rare event and its diagnosis and treatment are a real medical challenge. During pregnancy, the hypothalamus-pituitary-adrenal axis undergoes major changes leading to a significant increase in plasma cortisol levels throughout gestation. The difficulties in diagnosis are related to the resemblance of symptoms of CS and those of pregnancy, and to the complex interpretation of the screening tests. Read More

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http://dx.doi.org/10.23736/S0391-1977.18.02803-1DOI Listing
December 2018
3 Reads
1.320 Impact Factor

A human exposure based mixture of persistent organic pollutants affects the stress response in female mice and their offspring.

Chemosphere 2018 Apr 18;197:585-593. Epub 2018 Jan 18.

Section for Experimental Biomedicine, Department of Production Animal Clinical Sciences, Norwegian University of Life Sciences, Norway.

Persistent organic pollutants (POPs) are found in the food chain of both humans and animals and exert a wide spectrum of potentially adverse effects. The present experiment aimed to investigate whether a defined mixture of 29 POPs, based on the dietary intake of Scandinavians, could affect the stress response in female mice exposed through ingestion, and in their offspring. Female mice 129:C57BL/6F0 hybrids were exposed from weaning, throughout pregnancy, and up until necropsy, to either 5000 × or 100 000 × the estimated daily intake for Scandinavians. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2018.01.085DOI Listing
April 2018
5 Reads

Female gonadal functions and ovarian reserve in patients with acromegaly: experience from a single tertiary center.

Endocrine 2018 04 5;60(1):167-174. Epub 2018 Feb 5.

Department of Internal Medicine, Division of Endocrinology and Metabolism, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey.

Purpose: To evaluate the gonadal functions and related factors in female patients with acromegaly at the time of diagnosis, the course of gonadal dysfunctions and pregnancies during the follow-up period, and the investigation of ovarian reserve with serum anti-Mullerian hormone (AMH) levels in patients with reproductive age.

Methods: Patients who were not menopausal at the time of acromegaly diagnosis (n = 47) were included in this study. Baseline gonadal status was evaluated retrospectively. Read More

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http://dx.doi.org/10.1007/s12020-018-1540-5DOI Listing
April 2018
5 Reads

Postpartum depression and vitamin D: A systematic review.

Crit Rev Food Sci Nutr 2018 Feb 2:1-7. Epub 2018 Feb 2.

c Food Security Research Center, Isfahan University of Medical Sciences , Isfahan , Iran.

Postpartum depression (PPD) is a prevalent mood disorder estimated to affect 20%-40% of women worldwide after childbirth. In recent studies, the effect of vitamin D on prevention of mood disorders and depression has been investigated, but it is still unclear how vitamin D may affect PPD. The evidence on the relevance between vitamin D deficiency and PPD is inconsistent, and assessment of the recent literature has not previously been carried out. Read More

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http://dx.doi.org/10.1080/10408398.2017.1423276DOI Listing
February 2018
6 Reads

The clinical course and pathophysiological investigation of adolescent gestational diabetes insipidus: a case report.

BMC Endocr Disord 2018 Jan 30;18(1). Epub 2018 Jan 30.

Department of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, 1-1-1 Chuo-Ward, Honjo, Kumamoto, 860-8556, Japan.

Background: Gestational diabetes insipidus (GDI) is a rare endocrine complication during pregnancy that is associated with vasopressinase overproduction from the placenta. Although increased vasopressinase is associated with placental volume, the regulation of placental growth in the later stage of pregnancy is not well known.

Case Presentation: A 16-year-old pregnant woman was urgently transferred to our hospital because of threatened premature labor when the Kumamoto earthquakes hit the area where she lived. Read More

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http://dx.doi.org/10.1186/s12902-018-0234-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5789627PMC
January 2018
13 Reads

[Clinical features and prognosis of 18 cases of primary lymphocytic hypophysitis].

Zhonghua Yi Xue Za Zhi 2018 Jan;98(2):102-108

Department of Endocrinology, Chinese PLA General Hospital, Beijing 100853, China.

To analyze clinical features, prognosis and treatment of lymphocytic hypophysitis (LYH). The clinical data, treatments and outcomes of 18 cases diagnosed as LYH at Chinese PLA General Hospital between January 2001 and July 2017 was respectively reviewed. Eighteen patients with histology-proven LYH (13 females and 5 males ) were identified. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2018.02.006DOI Listing
January 2018
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Prenatal maternal psychosocial stress and offspring's asthma and allergic disease: A systematic review and meta-analysis.

Clin Exp Allergy 2018 Apr 8;48(4):403-414. Epub 2018 Feb 8.

Asthma UK Centre for Applied Research, Centre for Medical Informatics, Usher Institute of Population Health Sciences and Informatics, The University of Edinburgh, Edinburgh, UK.

Background: Prenatal maternal stress may influence offspring's atopic risk through sustained cortisol secretion resulting from activation of the hypothalamic-pituitary axis (HPA), leading to Th2-biased cell differentiation in the foetus. We undertook a systematic review and meta-analysis investigating the relationship between prenatal maternal psychosocial stress and risk of asthma and allergy in the offspring.

Methods: We searched 11 electronic databases from 1960 to 2016, searched the grey literature and contacted experts in the field. Read More

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http://dx.doi.org/10.1111/cea.13091DOI Listing
April 2018
9 Reads

Pregnancy in a woman with acromegaly after transsphenoidal partial resection of pituitary macroadenoma - a case report.

Pol Merkur Lekarski 2017 Dec;43(258):268-271

Department of Maternal and Child Health , Gynaecology and Obstetrics Hospital of the Medical University.

Acromegaly is a systemic disease caused by an excessive release of growth hormone and the hypopituitarism, which is induced by macroadenoma local mass effect. The gynecological and obstetric disorders include irregular menstrual cycles, anovulatory cycles and infertility. Therefore, pregnancy in patients affected by the disease is rare. Read More

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December 2017
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Polymorphisms of caprine GnRHR gene and their association with litter size in West African Dwarf goats.

Mol Biol Rep 2018 Feb 29;45(1):63-69. Epub 2017 Dec 29.

Department of Animal Breeding and Genetics, Federal University of Agriculture, Abeokuta, Nigeria.

Gonadotropin-releasing hormone receptor (GnRHR) gene is considered a candidate gene for litter size due to its critical role in regulating the activities of hypothalamo-pituitary-gonadal axis which synthesizes and releases gonadotropins. This study was designed to identify mutations within the caprine GnRHR gene and investigate their association with litter size at various parities. Polymorphisms scanning and genotyping of GnRHR gene in West African Dwarf (WAD) goats (n = 226) revealed three single nucleotide polymorphisms (SNPs), one mutation (g. Read More

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http://link.springer.com/10.1007/s11033-017-4141-0
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http://dx.doi.org/10.1007/s11033-017-4141-0DOI Listing
February 2018
22 Reads