4,936 results match your criteria Pituitary Disease and Pregnancy


Graves' disease.

Nat Rev Dis Primers 2020 Jul 2;6(1):52. Epub 2020 Jul 2.

Department of Medicine I, Johannes Gutenberg University Medical Centre, Mainz, Germany.

Graves' disease (GD) is an autoimmune disease that primarily affects the thyroid gland. It is the most common cause of hyperthyroidism and occurs at all ages but especially in women of reproductive age. Graves' hyperthyroidism is caused by autoantibodies to the thyroid-stimulating hormone receptor (TSHR) that act as agonists and induce excessive thyroid hormone secretion, releasing the thyroid gland from pituitary control. Read More

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http://dx.doi.org/10.1038/s41572-020-0184-yDOI Listing

The Incidence of Pregnancy-Associated Cushing's Disease and Its Relation to Pregnancy: A Retrospective Study.

Front Endocrinol (Lausanne) 2020 29;11:305. Epub 2020 May 29.

Key Laboratory of Endocrinology of National Health Commission, Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.

Cushing's disease (CD) is one of the most severe endocrine disorders and primarily affects women of reproductive age. The peripartum period has been observed to be a common time to develop CD. This study aims to retrospectively analyze the clinical characteristics of CD potentially associated with pregnancy and to evaluate relevant pregnancy outcomes. Read More

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http://dx.doi.org/10.3389/fendo.2020.00305DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7272570PMC

Consequences of maternal psychological stress during pregnancy for the risk of asthma in the offspring.

Scand J Immunol 2020 Jun 15:e12919. Epub 2020 Jun 15.

Department of Medicine, University of Cambridge, Cambridge.

Asthma is a common lung condition that makes breathing difficult through the inflammation and constriction of the lung airways. Epidemiological evidence supports the presence of a positive association between prenatal maternal psychological stress (PMPS) and asthma in the offspring, suggesting the disease may have developmental origins. T-helper 2 (Th2) cells are a major subtype of T-helper cells, producing Th2 cytokines, which may be the main drivers of asthma symptoms. Read More

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http://dx.doi.org/10.1111/sji.12919DOI Listing

Early maternal separation accelerates the progression of endometriosis in adult mice.

Reprod Biol Endocrinol 2020 Jun 12;18(1):63. Epub 2020 Jun 12.

Shanghai Obstetrics and Gynecology Hospital, Fudan University, Shanghai, 200090, China.

Background: A large body of research highlights the importance of early-life environmental impact on the health outcome in adulthood. However, whether early-life adversity (ELA) has any impact on the development of endometriosis is completely unclear. In this study, we tested the hypothesis that ELA, as manifested by neonatal separation, can accelerate the progression of endometriosis in mouse through activation of the adrenergic receptor β2 (ADRB2) signaling pathway, leading to increased angiogenesis and progression of endometriotic lesions. Read More

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http://dx.doi.org/10.1186/s12958-020-00600-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7291455PMC

Psycho-neuro-endocrino-immunologic issues in multiple sclerosis: a critical review of clinical and therapeutic implications.

Hormones (Athens) 2020 Jun 1. Epub 2020 Jun 1.

University Research Institute of Maternal and Child Health and Precision Medicine, Medical School, National and Kapodistrian University of Athens, Athens, Greece.

Multiple sclerosis (MS) is a multifactorial, chronic, immune-mediated, and neurodegenerative disease, having a well-known hypothalamic-pituitary-adrenal (HPA) axis dysfunction. Several hormones have a great impact in the immune dysregulation, psychology, and cognitive status of patients with MS, as also in the fertility and response to treatment. In this comprehensive review, as an introduction, we mention basic data concerning MS: epidemiology, genetics, immunogenetics, epigenetics, pathophysiology, and neuroimmunology. Read More

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http://dx.doi.org/10.1007/s42000-020-00197-8DOI Listing

Pregnancy during the course of Cushing's syndrome: a case report and literature review.

Endocrinol Diabetes Metab Case Rep 2020 Apr 12;2020. Epub 2020 Apr 12.

Division of Endocrinology, Guillermo Almenara Irigoyen National Hospital, Lima, Peru.

Summary: Cushing's syndrome is an endocrine disorder that causes anovulatory infertility secondary to hypercortisolism; therefore, pregnancy rarely occurs during its course. We present the case of a 24-year-old, 16-week pregnant female with a 10-month history of unintentional weight gain, dorsal gibbus, nonpruritic comedones, hirsutism and hair loss. Initial biochemical, hormonal and ultrasound investigations revealed hypokalemia, increased nocturnal cortisolemia and a right adrenal mass. Read More

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http://dx.doi.org/10.1530/EDM-20-0022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7159255PMC

Stress, strain, and pregnancy outcome in postpartum cows.

Authors:
Matthew C Lucy

Anim Reprod 2019 Oct 23;16(3):455-464. Epub 2019 Oct 23.

Division of Animal Sciences, University of Missouri, Animal Science Research Center, Columbia, MO, USA.

Stress affects the productivity and fertility of cattle. Stress causes strain and individual animals experience different amounts of strain in response to the same amount of stress. The amount of strain determines the impact of stress on fertility. Read More

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http://dx.doi.org/10.21451/1984-3143-AR2019-0063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7234163PMC
October 2019

Pregnancy-related reference intervals for serum thyrotropin based on real-life clinical data.

Gynecol Endocrinol 2020 Apr 23:1-4. Epub 2020 Apr 23.

Laboratorio analisi chimico-cliniche e di endocrinologia, Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy.

During pregnancy, thyroid homeostasis is physiologically modified, leading to altered levels of thyrotropin (TSH): hence, the adoption of pregnancy-related, population- and method-specific reference ranges is recommended. This monocentric and retrospective study was conducted to establish local pregnancy-related reference intervals for serum TSH in singleton pregnant women using real-life clinical data. We included women who measured serum TSH during pregnancy at our Laboratory over six years, excluding pregnant women with current or past history of thyroid disease, pituitary or autoimmune diseases, use of medications known to influence thyroid function, multiple and/or pathological pregnancies, BMI >30 Kg/m. Read More

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http://dx.doi.org/10.1080/09513590.2020.1756251DOI Listing

Glucocorticoid receptor sensitivity in early pregnancy in an African American cohort.

Am J Reprod Immunol 2020 Jul 23;84(1):e13252. Epub 2020 May 23.

Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA.

Problem: Disruption in homeostatic feedback loops between inflammatory mediators and the hypothalamic-pituitary-adrenal (HPA) axis is a key mechanism linking chronic stress to inflammation and adverse health outcomes, including those occurring during pregnancy. In particular, alterations in glucocorticoid sensitivity may occur as a result of chronic stress, including that due to racial discrimination, and may be implicated in the persistent adverse maternal and infant health outcomes experienced by African Americans. While there are a few large-scale studies in human pregnancy that measure both cytokines and HPA axis hormones, to our knowledge, none directly measure glucocorticoid sensitivity at the cellular level, especially in an African American population. Read More

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http://dx.doi.org/10.1111/aji.13252DOI Listing

Ontogeny of Hypothalamus-Pituitary Gonadal Axis and Minipuberty: An Ongoing Debate?

Front Endocrinol (Lausanne) 2020 7;11:187. Epub 2020 Apr 7.

Unit of Endocrinology, Bambino Gesù Children's Hospital (IRCCS), Rome, Italy.

The fetal hypothalamus-pituitary gonadal (HPG) axis begins to function during mid-gestation but its activity decreases during late pregnancy due to the suppressive effects of placental estrogens. Placental hormones drop immediately after birth, FSH and LH surge at around 1 week and peak between 1 and 3 months of life. The HPG axis is activated in both sexes, but a sexual dimorphism is evident with higher LH values in boys, while FSH prevails in girls. Read More

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http://dx.doi.org/10.3389/fendo.2020.00187DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7154076PMC

[Clinical and genetic studies of a three-member familial isolated pituitary adenoma with homogeneous prolactinomas].

Medicina (B Aires) 2020 ;80(2):181-184

Department of Endocrinology, Centre Hospitalier Universitaire de Liège, University of Liege, Liege, Belgium. E-mail:

Most pituitary adenomas are sporadic, but 3-5% can occur in a family and hereditary context. This is the case of multiple endocrine neoplasia type 1 (MEN1), Carney complex (CNC) and familial isolated pituitary adenomas (FIPA). FIPA is an infrequent condition that occurs in a family context, not associated with MEN type1 or CNC. Read More

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Alterations in endogenous progesterone metabolism associated with spontaneous very preterm delivery.

Hum Reprod Open 2020 6;2020(2):hoaa007. Epub 2020 Apr 6.

Division of Clinical Pharmacology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.

Study Question: Do maternal serum levels of progesterone metabolites early in pregnancy correspond to an increased risk for very preterm delivery prior to 32 weeks?

Summary Answer: Maternal serum levels of 11-deoxycorticosterone (DOC) measured during the late first trimester or early second trimester correlate with an increased risk for preterm delivery prior to 32 weeks, and the correlation becomes stronger when the ratio of DOC to 16-alpha-hydroxyprogesterone was measured.

What Is Known Already: Progesterone is a pro-gestational steroid hormone that has been shown to decrease the risk of preterm birth in some pregnant women. Progesterone is metabolized by the body into various metabolites including members of the mineralocorticoid and glucocorticoid families. Read More

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http://dx.doi.org/10.1093/hropen/hoaa007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7133115PMC

Implications of early life stress on fetal metabolic programming of schizophrenia: A focus on epiphenomena underlying morbidity and early mortality.

Prog Neuropsychopharmacol Biol Psychiatry 2020 Jul 4;101:109910. Epub 2020 Mar 4.

Centre for Global Health, Trinity College Dublin, Dublin, Ireland; Department of Psychology, Trinity College Dublin, Dublin, Ireland; School of Medicine, Trinity College Dublin, Dublin, Ireland.

The fetal origin of adult disease hypothesis postulates that a stressful in utero environment can have deleterious consequences on fetal programming, potentially leading to chronic disease in later life. Factors known to impact fetal programming include the timing, intensity, duration and nature of the external stressor during pregnancy. As such, dynamic modulation of fetal programming is heavily involved in shaping health throughout the life course, possibly by influencing metabolic parameters including insulin action, hypothalamic-pituitary-adrenal activity and immune function. Read More

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http://dx.doi.org/10.1016/j.pnpbp.2020.109910DOI Listing

[Research progress of kisspeptin in female reproductive endocrine and assisted reproductive techniques].

Sheng Li Xue Bao 2020 Feb;72(1):125-132

Reproductive Medicine Center, the Second Affiliated Hospital of Naval Military Medical University, Shanghai 200003, China.

In recent years, it has been found that kisspeptin plays some key roles in the physiological processes of the brain, such as gender differentiation, positive and negative feedback of sex hormones, onset of puberty, and transduction of energy signals in the body, which suggests that kisspeptin may be a key molecule for the maturation and regulation of female reproductive function. In addition to the systemic roles of the kisspeptin, its local roles in reproductive organs are constantly being discovered. With the discovery that kisspeptin is involved in the pathological process of reproductive endocrine diseases such as isolated hypogonadotropic hypogonadism (IHH), polycystic ovary syndrome (PCOS), premature ovarian failure (POF) and pathological hyperprolactinemia, exogenous application of kisspeptin to solve reproductive problems has become a new hot topic. Read More

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February 2020

Sleep disordered breathing in pregnancy: A review of the pathophysiology of adverse pregnancy outcomes.

Acta Physiol (Oxf) 2020 Jun 10;229(2):e13458. Epub 2020 Mar 10.

Tommy's Centre for Maternal and Fetal Health, MRC Centre for Reproductive Health, University of Edinburgh, Queen's Medical Research Institute, Edinburgh, United Kingdom.

Sleep disordered breathing (SDB) is a common obesity-related co-morbidity with strong associations to cardiometabolic disease. The risk of SDB is increased during pregnancy, particularly among obese pregnant women. Accumulating evidence suggests that an association exists between maternal SDB and the development of adverse pregnancy outcomes, particularly gestational diabetes and hypertensive disorders of pregnancy. Read More

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http://dx.doi.org/10.1111/apha.13458DOI Listing

Chronic psychosocial stress during pregnancy affects maternal behavior and neuroendocrine function and modulates hypothalamic CRH and nuclear steroid receptor expression.

Transl Psychiatry 2020 Jan 16;10(1). Epub 2020 Jan 16.

Center for the Prevention of Preterm Birth, Perinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.

Postpartum depression (PPD) affects up to 20% of mothers and has negative consequences for both mother and child. Although exposure to psychosocial stress during pregnancy and abnormalities in the hypothalamic pituitary adrenal (HPA) axis have been linked to PPD, molecular changes in the brain that contribute to this disease remain unknown. This study utilized a novel chronic psychosocial stress paradigm during pregnancy (CGS) to investigate the effects of psychosocial stress on maternal behavior, neuroendocrine function, and gene expression changes in molecular regulators of the HPA axis in the early postpartum period. Read More

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http://dx.doi.org/10.1038/s41398-020-0704-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7026416PMC
January 2020

Loss-of-Function Variants in TBC1D32 Underlie Syndromic Hypopituitarism.

J Clin Endocrinol Metab 2020 Jun;105(6)

Pediatric Research Center, Helsinki University Hospital, New Children's Hospital, Pediatric Research Center, Helsinki, Finland.

Context: Congenital pituitary hormone deficiencies with syndromic phenotypes and/or familial occurrence suggest genetic hypopituitarism; however, in many such patients the underlying molecular basis of the disease remains unknown.

Objective: To describe patients with syndromic hypopituitarism due to biallelic loss-of-function variants in TBC1D32, a gene implicated in Sonic Hedgehog (Shh) signaling.

Setting: Referral center. Read More

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http://dx.doi.org/10.1210/clinem/dgaa078DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7138537PMC

Time for a New Perspective on Prolactin in Metabolism.

Trends Endocrinol Metab 2020 Apr 7;31(4):276-286. Epub 2020 Feb 7.

Instituto de Neurobiología, Universidad Nacional Autónoma de México (UNAM), Campus UNAM-Juriquilla, 76230 Querétaro, México.

The pituitary hormone prolactin (PRL) regulates a variety of functions beyond reproduction. The association between physiological (pregnancy) and pathological (prolactinoma) hyperprolactinemia and metabolic alterations led to the concept of this hormone being diabetogenic. However, large cohort clinical studies have recently shown that low circulating PRL levels are associated with metabolic disease and represent a risk factor for type 2 diabetes (T2D), whereas high PRL levels are beneficial. Read More

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http://dx.doi.org/10.1016/j.tem.2020.01.004DOI Listing

Temporal trend of diabetes in pregnant women and its association with birth outcomes, 2011 to 2017.

J Diabetes Complications 2020 Apr 24;34(4):107550. Epub 2020 Jan 24.

University of New South Wales, Sydney, Australia; Agency for Clinical Innovation, NSW Health, Australia. Electronic address:

Aim: To assess changes in the prevalence of diabetes in pregnant women, and its association with selected birth outcomes (including caesarean section, episiotomy, admission to the special care nursery/neonatal intensive care unit, postpartum haemorrhage and neonatal birth weight) from 2011 to 2017.

Methods: In a single-centre, retrospective cohort study, we examined records of pregnant women who attended an Australian tertiary hospital between 2011 and 2017, identifying women with gestational diabetes mellitus and pre-existing diabetes mellitus, and examined trends associated with diabetes and their effects on birth outcomes.

Results: The average incidence of women with diabetes increased by 9% annually (RR = 0. Read More

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http://dx.doi.org/10.1016/j.jdiacomp.2020.107550DOI Listing

Restoration of fertility in a woman with giant prolactinoma in response to cabergoline treatment.

Endocrinol Diabetes Metab Case Rep 2019 Sep 6;2019. Epub 2019 Sep 6.

Department of English Language for Natural FacultiesLomonosov Moscow State University, Moscow, Russian Federation.

Summary: A 32-year-old woman presented with primary amenorrhoea, prolactin (PRL) level of 154 150 mIU/L and was diagnosed with a giant pituitary adenoma measuring maximum 6.2 cm. Cabergoline (CAB) treatment at a dose of 0. Read More

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http://dx.doi.org/10.1530/EDM-19-0023DOI Listing
September 2019

Maternal exposure to air pollution during pregnancy and cortisol level in cord blood.

Sci Total Environ 2020 Apr 10;713:136622. Epub 2020 Jan 10.

ISGlobal, Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Spain.

Exposure to air pollution has been associated with disorders of the endocrine system and hypothalamic-pituitary-adrenal (HPA) axis; however, the available evidence on these associations is still scarce. This study aimed to investigate, for the first time, the association of exposure to PM, PM, and PM, as well as traffic indicators (distance to major roads and total street length in different buffers around maternal residential address) during pregnancy with cortisol level in cord blood samples. This cross-sectional study was carried out based on 150 mother-newborn pairs in Sabzevar, Iran (2018). Read More

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http://dx.doi.org/10.1016/j.scitotenv.2020.136622DOI Listing

Thyroid Function During the Fetal and Neonatal Periods.

Neoreviews 2020 01;21(1):e30-e36

Division of Pediatric Endocrinology and Diabetes, The Children's Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, NY.

Thyroid hormones are essential during infancy and childhood for growth and brain development. The formation and maturation of the newborn's hypothalamic-pituitary-thyroid axis begin in utero with fetal dependence on maternal thyroid hormones early in the pregnancy. As the fetal thyroid gland begins to produce thyroid hormones in the second trimester, the reliance decreases and remains at lower levels until birth. Read More

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http://dx.doi.org/10.1542/neo.21-1-e30DOI Listing
January 2020

Biochemical diagnosis in prolactinomas: some caveats.

Pituitary 2020 Feb;23(1):9-15

ENDOC Center for Endocrine Tumors, Erik-Blumenfeld-Platz 27a, 22587, Hamburg, Germany.

Prolactinomas are the most frequently seen pituitary adenomas in clinical practice. A correct biochemical diagnosis of hyperprolactinemia is a prerequisite for further investigation but may be hampered by analytical difficulties as well as a large number of potentially overlapping conditions associated with increased prolactin levels. Suspicion should rise in patients whose symptoms and biochemical results do not match. Read More

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http://dx.doi.org/10.1007/s11102-019-01024-zDOI Listing
February 2020

Surgery for prolactinomas: a better choice?

Pituitary 2020 Feb;23(1):45-51

Department of Neurosurgery, University of Tübingen, Hoppe-Seyler-Straße 3, 72076, Tübingen, Germany.

Purpose: Renewed interest in transsphenoidal surgery (TSS) as a therapeutic option for prolactinomas has emerged.

Methods: Based on contemporary literature and own experience, the changing role of surgery for treatment of prolactinomas is discussed.

Results: Today, TSS is performed by minimally invasive microscopic or endoscopic techniques. Read More

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http://dx.doi.org/10.1007/s11102-019-01016-zDOI Listing
February 2020

Primary ovarian insufficiency associated with pazopanib therapy in a breast angiosarcoma patient: A CARE-compliant case report.

Medicine (Baltimore) 2019 Dec;98(50):e18089

Department of Medical Oncology and Hematology, Humanitas Cancer Center, Humanitas Clinical and Research Center - IRCCS, Rozzano (MI).

Rational: The growing population of young cancer survivors and a trend toward postponing pregnancy until later years in life are leading to a deeper attention towards understanding treatment-induced sequelae, and, in particular, the effects of cancer and/or treatment on fertility. Nowadays, the infertility risks potentially associated with molecular targeted therapies are not established, and clinical reports are sparse. Moreover, the increasing use of molecular targeted drugs in the adjuvant setting and in diseases with better prognosis makes preservation of fertility a major topic in current research. Read More

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http://dx.doi.org/10.1097/MD.0000000000018089DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6922591PMC
December 2019

Perinatal programming of metabolic diseases: The role of glucocorticoids.

Metabolism 2020 03 11;104:154047. Epub 2019 Dec 11.

Research Group on Perinatal Programming of Metabolic Diseases: DOHaD concept, Laboratory of Metabolic and Cardiovascular Diseases, Health Education and Research Center, NUPADS, Institute of Health Sciences, Federal University of Mato Grosso, University Campus of Sinop, Sinop, MT, Brazil. Electronic address:

The worldwide increase in metabolic diseases has urged the scientific community to improve our understanding about the mechanisms underlying its cause and effects. A well supported area of studies had related maternal stress with early programming to the later metabolic diseases. Mechanisms upon origins of metabolic disturbances are not yet fully understood, even though stressful factors rising glucocorticoids have been put out as pivotal trigger by programming metabolic diseases as long-term consequence. Read More

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http://dx.doi.org/10.1016/j.metabol.2019.154047DOI Listing

Surgical indications for pituitary tumors during pregnancy: a literature review.

Pituitary 2020 Apr;23(2):189-199

Neurosurgery Department, Aix-Marseille Univ, APHM, CHU Timone, La Timone Hospital, 264 rue Saint-Pierre, 13005, Marseille, France.

Purpose: Surgical indications for pituitary tumors during pregnancy are rare, and are derived from a balance between expected benefits, particularly for maternal benefits, and anesthetic/surgical risks.

Methods: A literature review was performed to define the optimal surgical indications for pituitary adenomas (PA) and other pituitary tumors during pregnancy.

Results: Main benefits are expected in case of critical visual impairment and/or life-threatening endocrine disturbances. Read More

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http://dx.doi.org/10.1007/s11102-019-01004-3DOI Listing

The reproductive stress hypothesis.

Reproduction 2019 12;158(6):R209-R218

Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Hunan Agricultural University, Changsha, People's Republic of China.

In this paper, we propose the reproductive stress hypothesis that describes the pregnant females response to reproductive events based upon the activation of the hypothalamic-pituitary-adrenal axis and sympathetic adrenomedullary system. The main components of the reproductive stress hypothesis can be summarized as follows: (1) events unique to reproduction including empathema, pregnancy, parturition and lactation cause non-specific responses in females, called active reproductive stress; (2) the fetus is a special stressor for pregnant females where endocrine hormones, including corticotropin-releasing hormones and fetal glucocorticoids secreted by the fetus and placenta, enter the maternal circulatory system, leading to another stress response referred to as passive reproductive stress and (3) response to uterine tension and intrauterine infection is the third type of stress, called fetal intrauterine stress. Appropriate reproductive stress is a crucial prerequisite in normal reproductive processes. Read More

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http://dx.doi.org/10.1530/REP-18-0592DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6892456PMC
December 2019

[Anti-estreptavidin antibodies. Diagnostic confusion by biochemical interference].

Medicina (B Aires) 2019 ;79(5):419-423

Laboratorio Central, Sanatorio Allende, Córdoba, Argentina.

We present the case of a patient who, during studies for fertility and subsequent pregnancy, showed an altered thyroid profile with elevated levels of free T4 and normal TSH. After ruling out a thyrotropic adenoma and in the absence of clinical symptoms of hyperthyroidism, the possibility of analytical interference in the immunoassays used to measure hormones was investigated. Interferences caused by heterophile antibodies, macro TSH, anti-thyroid antibodies, biotin, and to a lesser extent anti-streptavidin and anti-ruthenium antibodies have been described. Read More

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December 2019
2 Reads

The first two Chinese Myhre syndrome patients with the recurrent SMAD4 pathogenic variants: Functional consequences and clinical diversity.

Clin Chim Acta 2020 Jan 22;500:128-134. Epub 2019 Oct 22.

Department of Genetics and Metabolism, Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, Nanning 530003, Guangxi, China; Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China; Division of Genetics and Genomics, Boston Children's Hospital, Boston, MA, United States; Department of Neurology, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, United States. Electronic address:

Myhre syndrome is a rare autosomal dominant multi-organ disorder characterized by growth retardation, skeletal anomalies, muscular hypertrophy, joint stiffness, facial dysmorphism, deafness, cardiovascular disease, and abnormal sexual development. Here we described the first two Chinese Myhre syndrome patients diagnosed by whole-exome sequencing. They both had de novo c. Read More

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http://dx.doi.org/10.1016/j.cca.2019.10.006DOI Listing
January 2020
2.824 Impact Factor

In-utero stress and mode of conception: impact on regulation of imprinted genes, fetal development and future health.

Hum Reprod Update 2019 11;25(6):777-801

First Department of Obstetrics and Gynecology, Laboratory of Genetics, School of Medicine, Aristotle University of Thessaloniki, Papageorgiou General Hospital, Ring Road, Nea Efkarpia, 56403 Thessaloniki, Greece.

Background: Genomic imprinting is an epigenetic gene regulatory mechanism; disruption of this process during early embryonic development can have major consequences on both fetal and placental development. The periconceptional period and intrauterine life are crucial for determining long-term susceptibility to diseases. Treatments and procedures in assisted reproductive technologies (ART) and adverse in-utero environments may modify the methylation levels of genomic imprinting regions, including insulin-like growth factor 2 (IGF2)/H19, mesoderm-specific transcript (MEST), and paternally expressed gene 10 (PEG10), affecting the development of the fetus. Read More

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http://dx.doi.org/10.1093/humupd/dmz025DOI Listing
November 2019
1 Read

Extraordinary case presentations in pediatric pituitary adenoma: report of 6 cases.

J Neurosurg Pediatr 2019 Oct 11:1-8. Epub 2019 Oct 11.

Pediatric pituitary adenomas (PPAs) are rare neoplasms with a propensity for unusual presentations and an aggressive clinical course. Here, the authors describe 6 highly atypical PPAs to highlight this tendency and discuss unexpected management challenges.A 14-year-old girl presented with acute hemiparesis and aphasia. Read More

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http://dx.doi.org/10.3171/2019.7.PEDS1950DOI Listing
October 2019
2 Reads

Microalgae supplementation to late gestation sows and its effects on the health status of weaned piglets fed diets containing high- or low-quality protein sources.

Vet Immunol Immunopathol 2019 Dec 3;218:109937. Epub 2019 Sep 3.

Department of Animal Biosciences, University of Guelph, ON, N1G2W1, Canada. Electronic address:

Maternal stress, such as a bacterial infection occurring in late gestation, may predispose offspring to a variety of diseases later in life. It may also alter programming of developing systems within the fetus, such as the hypothalamic-pituitary-adrenal (HPA) axis and immune system. Dietary supplementation during the last trimester of pregnancy with immune-modulating compounds may be a means of reducing potential adverse effects of maternal stress on the developing fetus. Read More

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http://dx.doi.org/10.1016/j.vetimm.2019.109937DOI Listing
December 2019
3 Reads

Obesity, Neuroinflammation, and Reproductive Function.

Endocrinology 2019 11;160(11):2719-2736

Division of Biomedical Sciences, School of Medicine, University of California, Riverside, Riverside, California.

The increasing occurrence of obesity has become a significant public health concern. Individuals with obesity have higher prevalence of heart disease, stroke, osteoarthritis, diabetes, and reproductive disorders. Reproductive problems include menstrual irregularities, pregnancy complications, and infertility due to anovulation, in women, and lower testosterone and diminished sperm count, in men. Read More

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http://dx.doi.org/10.1210/en.2019-00487DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6806266PMC
November 2019
2 Reads

Involvement of Novel Adipokines, Chemerin, Visfatin, Resistin and Apelin in Reproductive Functions in Normal and Pathological Conditions in Humans and Animal Models.

Int J Mol Sci 2019 Sep 9;20(18). Epub 2019 Sep 9.

INRA UMR 85 Physiologie de la Reproduction et des Comportements, F-37380 Nouzilly, France.

It is well known that adipokines are endocrine factors that are mainly secreted by white adipose tissue. Their central role in energy metabolism is currently accepted. More recently, their involvement in fertility regulation and the development of some reproductive disorders has been suggested. Read More

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http://dx.doi.org/10.3390/ijms20184431DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6769682PMC
September 2019
1 Read

Adrenal disorders in pregnancy, labour and postpartum - an overview.

J Obstet Gynaecol 2020 Aug 30;40(6):749-758. Epub 2019 Aug 30.

Department of Obstetrics and Gynaecology, Azra Naheed Medical College, Lahore, Pakistan.

Adrenal disorders may manifest during pregnancy for the first time, or present from before pregnancy as either undiagnosed or diagnosed and treated. They may present as hormonal hypofunction or hyperfunction, or with mass effects or other non-endocrine effects. Adrenal disorders such as Cushing's syndrome, Addison's disease, pheochromocytoma, primary hyper-aldosteronism and adreno-cortical carcinoma are rare in pregnancy. Read More

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http://dx.doi.org/10.1080/01443615.2019.1648395DOI Listing

The impact of heat stress on the immune system in dairy cattle: A review.

Res Vet Sci 2019 Oct 6;126:94-102. Epub 2019 Aug 6.

ICAR-National Institute of Animal Nutrition and Physiology, Adugodi, Bangalore 560030, Karnataka, India. Electronic address:

Heat stress is well documented to have a negative influence on livestock productivity and these impacts may be exacerbated by climate change. Dairy cattle can be more vulnerable to the negative effects of heat stress as these adverse impacts may be more profound during pregnancy and lactation. New emerging diseases are usually linked to a positive relationship with climate change and the survival of microrganisms and/or their vectors. Read More

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http://dx.doi.org/10.1016/j.rvsc.2019.08.011DOI Listing
October 2019
3 Reads

Multidisciplinary team efforts improve the surgical outcomes of sellar region lesions during pregnancy.

Endocrine 2019 12 17;66(3):477-484. Epub 2019 Aug 17.

Department of Neurosurgery, Center of Pituitary Tumor, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Purpose: Treatment of space-occupying lesions (SOLs) in the sellar region is a clinical challenge, especially in pregnant women because many treatment decisions are restrained due to pregnancy. We attempt to discuss the surgical indications and timing for pregnant patients and highlight the importance of multidisciplinary team (MDT) treatment.

Methods: From August 2017 to February 2018, four pregnant women were admitted to our hospital with severe visual impairment due to sellar region SOLs, including two cases of tuberculum sellae meningioma, one case of giant pituitary adenoma and one case of a pituitary abscess. Read More

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http://dx.doi.org/10.1007/s12020-019-02054-0DOI Listing
December 2019
3 Reads

Opioids and reproduction.

Vitam Horm 2019 26;111:247-279. Epub 2019 Jul 26.

Department of Gynecological Endocrinology and Reproductive Medicine, Medical University of Innsbruck, Innsbruck, Austria.

More than 40years ago, the endogenous opioids were first described. Their role as important neuromodulators of pain and their influence on a variety of neuroendocrine control systems within the central nervous system has been recognized. More recently, endogenous opioids and their receptor have been identified in a variety of reproductive and non-reproductive tissues outside the central nervous system. Read More

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http://dx.doi.org/10.1016/bs.vh.2019.07.001DOI Listing
March 2020
3 Reads

Reproductive functions of Kisspeptin/KISS1R Systems in the Periphery.

Reprod Biol Endocrinol 2019 Aug 9;17(1):65. Epub 2019 Aug 9.

Department of Physiology, Basic Medical College, Nanchang University, Nanchang, Jiangxi, 330006, People's Republic of China.

Kisspeptin and its G protein-coupled receptor KISS1R play key roles in mammalian reproduction due to their involvement in the onset of puberty and control of the hypothalamic-pituitary-gonadal axis. However, recent studies have indicated a potential role of extra-hypothalamic kisspeptin in reproductive function. Here, we summarize recent advances in our understanding of the physiological significance of kisspeptin/KISS1R in the peripheral reproductive system (including the ovary, testis, uterus, and placenta) and the potential role of kisspeptin/KISS1R in reproductive diseases. Read More

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http://dx.doi.org/10.1186/s12958-019-0511-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6689161PMC
August 2019
2 Reads

How much does obesity affect the male reproductive function?

Int J Obes Suppl 2019 Apr 12;9(1):50-64. Epub 2019 Apr 12.

2Department of Clinical Medicine and Surgery, 'Federico II' University of Naples, Naples, Italy.

Obesity is considered a worldwide epidemic disease. Many pathological conditions have been associated to obesity but the evidence relating to impaired fertility in males with obesity are contrasting. The aim of this review was to evaluate the interplay between obesity and male fertility, analyzing evidence from in vitro and in vivo studies to clinical trials. Read More

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http://dx.doi.org/10.1038/s41367-019-0008-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6683183PMC
April 2019
2 Reads

Other Pituitary Conditions and Pregnancy.

Authors:
Philippe Chanson

Endocrinol Metab Clin North Am 2019 09 18;48(3):583-603. Epub 2019 Jun 18.

Assistance Publique-Hôpitaux de Paris (P.C.), Hôpitaux Universitaires Paris-Sud, Hôpital de Bicêtre, Service d'Endocrinologie et des Maladies de la Reproduction, Centre de Référence des Maladies Rares de l'Hypophyse, 78 rue du Général Leclerc, Le Kremlin-Bicêtre F-94275, France; UMR S-1185, Fac Med Paris-Sud, Université Paris-Saclay, Le Kremlin-Bicêtre F-94276, France. Electronic address:

Diagnosis of lymphocytic hypophysitis occurring in the peripartum period is based on clinical and neuroradiological data and does not require a biopsy. Its course is generally spontaneously favorable in terms of mass effect but may require the administration of corticosteroids or even transsphenoidal resection. The course of pituitary deficiencies is highly variable; some cases recover over time, whereas others persist indefinitely. Read More

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http://dx.doi.org/10.1016/j.ecl.2019.05.005DOI Listing
September 2019
4 Reads

Pituitary Tumors in Pregnancy.

Endocrinol Metab Clin North Am 2019 09 13;48(3):569-581. Epub 2019 Jun 13.

Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine, 645 North Michigan Avenue, Suite 530, Chicago, IL 60611, USA. Electronic address:

Pituitary adenomas are common. The impact of pituitary tumors on fertility are mainly caused by oversecretion and/or undersecretion of pituitary hormones or compression of pituitary stalk and normal pituitary tissue by the tumor. Diagnosing and managing pituitary tumors during pregnancy involve many challenges, including the effect of hormone excess or deficiency on pregnancy outcome, changes in the pituitary or pituitary-related hormones, changes in tumor size, and the impact of various treatments of pituitary tumors on maternal and fetal outcomes. Read More

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http://dx.doi.org/10.1016/j.ecl.2019.05.004DOI Listing
September 2019
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The Development of Gonadotropins for Clinical Use in the Treatment of Infertility.

Front Endocrinol (Lausanne) 2019 3;10:429. Epub 2019 Jul 3.

Assisted Conception Unit, King's College London, Guy's Hospital, London, United Kingdom.

The first commercially available gonadotropin product was a human chorionic gonadotropin (hCG) extract, followed by animal pituitary gonadotropin extracts. These extracts were effective, leading to the introduction of the two-step protocol, which involved ovarian stimulation using animal gonadotropins followed by ovulation triggering using hCG. However, ovarian response to animal gonadotropins was maintained for only a short period of time due to immune recognition. Read More

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http://dx.doi.org/10.3389/fendo.2019.00429DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6616070PMC
July 2019
1 Read

Glyphosate-based herbicide exposure during pregnancy and lactation malprograms the male reproductive morphofunction in F1 offspring.

J Dev Orig Health Dis 2020 Apr 16;11(2):146-153. Epub 2019 Jul 16.

Laboratório de Fisiologia Endócrina e Metabolismo (LAFEM), Centro de Ciências Biológicas e da Saúde, Universidade Estadual do Oeste do Paraná, Cascavel, Brazil.

One of the most consumed pesticides in the world is glyphosate, the active ingredient in the herbicide ROUNDUP®. Studies demonstrate that glyphosate can act as an endocrine disruptor and that exposure to this substance at critical periods in the developmental period may program the fetus to induce reproductive damage in adulthood. Our hypothesis is that maternal exposure to glyphosate during pregnancy and lactation in mice will affect the development of male reproductive organs, impairing male fertility during adult life. Read More

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http://dx.doi.org/10.1017/S2040174419000382DOI Listing
April 2020
2 Reads

The adrenal cortex: Physiology and diseases in human pregnancy.

Eur J Obstet Gynecol Reprod Biol 2019 Sep 30;240:139-143. Epub 2019 Jun 30.

Department of Obstetrics and Gynecology, Hadassah University Hospital, Jerusalem, Israel.

Pregnancy is characterized by marked alterations in the hypothalamic-pituitary-adrenal axis and in the function of the adrenal gland. Some of those alterations have clinical characteristics that are similar to those of adrenal gland disorders. While adrenal disorders are rare among pregnant women, they harbor the potential for significant morbidity if they remain unrecognized and untreated. Read More

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http://dx.doi.org/10.1016/j.ejogrb.2019.06.036DOI Listing
September 2019
5 Reads

The role of glucagon-like peptide-1 in reproduction: from physiology to therapeutic perspective.

Hum Reprod Update 2019 07;25(4):504-517

Department of Endocrinology and Metabolism, Amsterdam University Medical Center, University of Amsterdam, Meibergdreef 9, Amsterdam, the Netherlands.

Background: Glucagon-like peptide-1 (GLP-1) receptor agonists (GLP-1 RAs) have become firmly established in the treatment of type 2 diabetes and obesity, disorders frequently associated with diminished reproductive health. Understanding of the role of GLP-1 and GLP-1 RAs in reproduction is currently limited and largely unaddressed in clinical studies.

Objective And Rationale: The purpose of this narrative review is to provide a comprehensive overview of the role of GLP-1 in reproduction and to address a therapeutic perspective that can be derived from these findings. Read More

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https://academic.oup.com/humupd/article/25/4/504/5514338
Publisher Site
http://dx.doi.org/10.1093/humupd/dmz019DOI Listing
July 2019
8 Reads