5,169 results match your criteria Pituitary Disease and Pregnancy

Anti-Mullerian as predictor of reproductive outcome in infertile women: follow up.

JBRA Assist Reprod 2014 Sep 27;18(3):80-84. Epub 2014 Sep 27.

Department of Reproductive Medicine, Hôpital Jean Verdier (AP-HP), University Paris XIII, and INSERM, U782, Clamart - France.

Objective: The aim of the present study was to investigate and to compare the relations of anti-Mullerian with the prognostic parameters and the outcome of assisted reproductive treatment.

Methods: Prospective longitudinal study. A total of one hundred and twelve infertile women. Read More

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September 2014

[Management of prolactinoma patients with pregnancy].

L J Wang H J Zhu

Zhonghua Nei Ke Za Zhi 2022 Jun;61(6):694-696

State Key Laboratory of Complex Severe and Rare Diseases, Key Laboratory of Endocrinology of National Health Commission, Department of Endocrinology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.

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Preventive online and offline health management intervention in polycystic ovary syndrome.

World J Clin Cases 2022 Apr;10(10):3060-3068

Dermatological Department, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing 101100, China.

Background: Polycystic ovary syndrome (PCOS) is characterized by hyperandrogenism, hyperinsulinemia, ovarian polycystic changes, and irregular ovulation, often occurring in women of childbearing age for whom it can be a cause of infertility. Hypothalamus-pituitary-ovarian axis dysregulation is important in the pathogenesis of PCOS and the associated chronic excess of sex hormones can lead to cardiovascular and cerebrovascular diseases, diabetes, and malignancies such as endometrial cancer, and breast cancer. At present, most scholars agree that lifestyle interventions in conjunction with drug treatment can help PCOS patients achieve their goals of successful pregnancy and childbirth. Read More

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[Central diabetes insipidus].

Rev Prat 2022 Apr;72(4):431-436

Service d'endocrinologie, diabétologie, maladies métaboliques, hôpital Avicenne, Bobigny, France Laboratoire Éducations et Pratiques de santé, EA 3412, université Sorbonne Paris Nord, France.

"Central diabetes insipidus Diabetes insipidus may remain undetected for a long time, the ionogram remaining normal as long as polydipsia compensates for diuresis. In the first place, and by argument of frequency, polyuria should rule out diabetes. Diabetes insipidus is evoked in the presence of an incapacitating polyuro polydipsic syndrome, especially at night. Read More

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Hyperprolactinaemia and galactorrhoea with combined oral contraceptive pill use: A refresher.

Aust J Gen Pract 2022 Jun;51(6):423-424

FRANZCOG, MRCOG, MRCPI, Obstetrics and Gynaecology Staff Specialist, Gold Coast University Hospital, Southport, Qld.

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Post COVID-19 Lymphocytic Hypophysitis: A Rare Presentation.

Child Neurol Open 2022 Jan-Dec;9:2329048X221103051. Epub 2022 May 20.

Divison of Neurology, Wright State University Boonshoft School of Medicine, Dayton, OH, USA.

Lymphocytic hypophysitis (LH) is a rare autoimmune disorder involving the destruction of the anterior pituitary due to lymphocytic infiltration. The disease shows a female predominance, commonly affecting women during late pregnancy into the postpartum period. The etiology of LH has not been well established and is presumed to be autoimmune based on the histopathological findings of lymphocytic infiltration and postpartum cases. Read More

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Gestational diabetes mellitus and adverse pregnancy outcomes: systematic review and meta-analysis.

BMJ 2022 05 25;377:e067946. Epub 2022 May 25.

Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, Hunan, China

Objective: To investigate the association between gestational diabetes mellitus and adverse outcomes of pregnancy after adjustment for at least minimal confounding factors.

Design: Systematic review and meta-analysis.

Data Sources: Web of Science, PubMed, Medline, and Cochrane Database of Systematic Reviews, from 1 January 1990 to 1 November 2021. Read More

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A rare endocrinological complication of chronic kidney disease.

Turk J Pediatr 2022 ;64(2):375-380

Divisions of Nephrology, Department of Pediatrics, University of Health Sciences, İzmir Tepecik Training and Research Hospital, İzmir.

Background: Chronic kidney disease (CKD) may lead to increase in serum levels of peptide hormones as a result of changes in peripheral metabolism. The pathogenesis of uremic hyperprolactinemia in CKD is not fully understood. Plasma prolactin levels are elevated in women, pubertal girls, and also in men with chronic kidney disease. Read More

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Maternal immune activation accelerates puberty initiation and alters mechanical allodynia in male and female C57BL6/J mice.

Dev Psychobiol 2022 07;64(5):e22278

School of Arts & Sciences, Health Psychology Program, Massachusetts College of Pharmacy and Health Sciences, Boston, Massachusetts, USA.

The mechanisms that link maternal immune activation (MIA) with the onset of neurodevelopmental disorders remain largely unclear. Accelerated puberty is also associated with a heightened risk for psychopathology in later life, but there is a dearth of evidence on the impacts of maternal infection on pubertal timing. We examined the effects of MIA on reproductive development, mechanical allodynia, and sensorimotor gating in juvenile, adolescent, and adult male and female mice. Read More

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Desmopressin Stimulation Test in a Pregnant Patient with Cushing's Disease.

AACE Clin Case Rep 2022 May-Jun;8(3):105-108. Epub 2021 Nov 26.

Division of Endocrinology and Metabolism, Department of Medicine, and Hormonal and Metabolic Research Unit, Excellence Center in Diabetes, Hormone and Metabolism, Faculty of Medicine, Chulalongkorn University, and King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand.

Objective: Hypothalamic-pituitary-adrenal axis stimulation during pregnancy complicates the investigation of Cushing's syndrome (CS). Our objective was to present the case of a pregnant patient with CS caused by a pituitary tumor in whom the desmopressin stimulation test helped in the diagnosis and led to appropriate management.

Case Report: A 27-year-old woman with 9-week gestation presented with a 2-month history of proximal myopathy. Read More

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November 2021

Follow-Up of Thyroid Function in Children With Neonatal Hyperthyroidism.

Front Endocrinol (Lausanne) 2022 4;13:877119. Epub 2022 May 4.

Department of Paediatrics and Endocrinology, Medical University of Warsaw, Warsaw, Poland.

Introduction: Neonatal hyperthyroidism mainly occurring in the children born to mothers with Graves' disease (GD). The influence of maternal GD on the newborn's thyroid function includes not only hyperthyroidism, but also various forms of hypothyroidism. Maternally transferred thyrotropin receptor antibodies (TRAb), the antithyroid drug (ATD) administration during pregnancy and previous definitive treatment of GD (radioactive iodine therapy or thyroidectomy) in the mother impact the function of the fetal/neonatal thyroid. Read More

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Ovulation triggering with hCG alone, GnRH agonist alone or in combination? A randomized controlled trial in advanced-age women undergoing IVF/ICSI cycles.

Hum Reprod 2022 May 20. Epub 2022 May 20.

Reproductive Medical Center, International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.

Study Question: Is a dual ovulation trigger with a combination of GnRH agonist (GnRHa) and hCG superior to single hCG and/or single GnRHa trigger in improving treatment outcomes in advanced-age women (aged ≥ 35 years) undergoing IVF/ICSI treatment?

Summary Answer: Co-administration of GnRHa and hCG as a dual trigger increases the number of good-quality embryos but it is not associated with a higher number of oocytes retrieved, compared with single hCG or GnRHa trigger.

What Is Known Already: Many studies have demonstrated that a dual trigger has positive impact on oocyte maturation, retrieval rate and pregnancy rate without increasing the risk of ovarian hyperstimulation syndrome (OHSS) in some groups of IVF patients, when compared with single hCG trigger. Few studies have however been conducted to compare a dual trigger with a single GnRHa trigger, and insufficient evidence exists to support which trigger can achieve the best outcomes in IVF patients aged ≥35 years. Read More

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Nat Rev Dis Primers 2022 05 19;8(1):30. Epub 2022 May 19.

Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, Netherlands.

Hypothyroidism is the common clinical condition of thyroid hormone deficiency and, if left untreated, can lead to serious adverse health effects on multiple organ systems, with the cardiovascular system as the most robustly studied target. Overt primary hypothyroidism is defined as elevated thyroid-stimulating hormone (TSH) concentration in combination with free thyroxine (fT) concentration below the reference range. Subclinical hypothyroidism, commonly considered an early sign of thyroid failure, is defined by elevated TSH concentrations but fT concentrations within the reference range. Read More

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Protocol for a Cross-Sectional Study: Effects of a Multiple Sclerosis Relapse Therapy With Methylprednisolone on Offspring Neurocognitive Development and Behavior (MS-Children).

Front Neurol 2022 26;13:830057. Epub 2022 Apr 26.

Department of Neurology, Jena University Hospital, Jena, Germany.

Introduction: Multiple Sclerosis (MS) is the most common neuroimmunological disease in women of childbearing age. Current MS therapy consists of immunomodulatory relapse prevention with disease-modifying therapies (DMTs) and acute relapse therapy with the synthetic glucocorticoid (GC) methylprednisolone (MP). As most DMTs are not approved for use during pregnancy, treatment is usually discontinued, increasing the risk for relapses. Read More

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Pre-eclampsia with paradoxical polyuria: diabetes insipidus in pregnancy.

Lancet 2022 05;399(10337):1809

Department of Medicine, Division of Endocrinology, National University Hospital, Singapore; Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

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Mild hyperprolactinemia in a couple: What impact on fertility?

Dominique Maiter

Ann Endocrinol (Paris) 2022 Jun 5;83(3):164-167. Epub 2022 May 5.

Service d'Endocrinologie et Nutrition, UCLouvain Cliniques Universitaires Saint-Luc, avenue Hippocrate 10, 1200 Bruxelles, Belgium. Electronic address:

Mild-to-moderate hyperprolactinemia is a frequent finding in young women presenting with infertility. Prolactin (PRL) concentration should be determined accurately, whether or not the patient has other symptoms suggestive of excess PRL such as galactorrhea or menstrual cycle disorder. After confirmation of persistent hyperprolactinemia on a second blood sample (avoiding conditions known to raise prolactin) and exclusion of macroprolactinemia, prolactinoma and other identifiable non-tumoral causes of hyperprolactinemia must be ruled out. Read More

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Elevated Beta-Human Chorionic Gonadotropin in a Non-pregnant Female With Altered Kidney Function.

Cureus 2022 Apr 1;14(4):e23747. Epub 2022 Apr 1.

Internal Medicine, University at Buffalo, Buffalo, USA.

Elevated beta-human chorionic gonadotropin (beta-hCG) levels in postmenopausal women is a finding known in the literature; however, it still commonly leads to unnecessary and extensive diagnostic workup. We present the case of a 48-year-old African-American postmenopausal female with acute kidney injury on chronic kidney disease (CKD) stage 5 and an incidental finding of elevated serum beta-hCG. Abdominal and transvaginal ultrasound showed no evidence of intrauterine or ectopic pregnancy or gestational trophoblastic disease. Read More

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The diagnosis and management of Cushing's syndrome in pregnancy.

J Neuroendocrinol 2022 Mar 14:e13118. Epub 2022 Mar 14.

Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.

Endogenous Cushing's syndrome (CS) is rarely encountered during pregnancy. Clinical and biochemical changes in healthy pregnancy overlap with those seen in pregnancy complicated by CS; the diagnosis is therefore challenging and can be delayed. During normal gestation, adrenocorticotrophic hormone, corticotrophin-releasing hormone, cortisol, and urinary free cortisol levels rise. Read More

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Prenatal earthquake stress exposure in different gestational trimesters is associated with methylation changes in the glucocorticoid receptor gene (NR3C1) and long-term working memory in adulthood.

Transl Psychiatry 2022 04 29;12(1):176. Epub 2022 Apr 29.

Department of Psychiatry, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei province, People's Republic of China.

Prenatal stress exposure is thought to affect the long-term development of the foetal brain via the HPA axis and to change health outcomes in adulthood, including working memory (WM). The potential mechanism is that there is a critical period of brain development of the foetus, which is a result of selective adaptation to the external environment. The human glucocorticoid gene (NR3C1) is associated with memory and cognition. Read More

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A prenatal case of Simpson-Golabi-Behmel syndrome type 1 with a 0.26-Mb deletion fragment at Xq26.2 inherited from mother: Case report.

Medicine (Baltimore) 2022 Apr 22;101(16):e29222. Epub 2022 Apr 22.

Xuzhou Central Hospital, Xuzhou Clinical Schools of Xuzhou Medical University and Nanjing Medical University, Xuzhou, Jiangsu, China.

Rationale: The purpose of this report was to explore how to manage the fetus of Simpson-Golabi-Behmel syndrome type 1 (SGBS1) and to provide a definite diagnosis to guide the following genetic counseling for the pregnancy.

Patient Concerns: A 24-year-old women, gravida 1, para 0, was 172 cm tall with weight 65 kg. She was referred to our center for counseling due to second-trimester ultrasound screening anomalies at 22 + 5 weeks of gestation age. Read More

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Differential diagnosis of pituitary enlargement.

Vnitr Lek 2022 ;68(1):58-63

Enlargement of the pituitary gland is heterogenous in the etiology. Common causes of pituitary enlargement are physiological hypertrophy during pregnancy, primary and secondary tumors, autoimmune hypophysitis including side effects of anticancer therapy with check-point inhibitors. Terms like hypertrophy, hyperplasia, sellar expansion and hypophysitis are commonly used to describe enlargement of the pituitary gland on MR scan regardless its etiology. Read More

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25-Hydroxyvitamin D and metabolic-related laboratory values in women with schizophrenia and hyperprolactinemia.

J Psychiatr Res 2022 Jul 8;151:25-29. Epub 2022 Apr 8.

Department of Psychiatry, University of Maryland School of Medicine, USA. Electronic address:

Schizophrenia is a severe mental disorder with various medical comorbidities and early mortality. Hyperprolactinemia is common in women and its impact on sexual function, galactorrhea and amenorrhea is well known. This paper evaluates the risk of 25-hydroxy vitamin D deficiency and other metabolic related laboratory abnormalities in women with schizophrenia having hyperprolactinemia (N = 43). Read More

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The underlying sex differences in neuroendocrine adaptations relevant to Myalgic Encephalomyelitis Chronic Fatigue Syndrome.

Front Neuroendocrinol 2022 Apr 11;66:100995. Epub 2022 Apr 11.

Department of Biochemistry & Pharmacology, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Australia.

Introduction: Myalgic Encephalomyelitis/ Chronic Fatigue Syndrome (ME/CFS) is a complex multisystem disease characterised by severe and disabling new-onset symptoms of post-exertional malaise (PEM), fatigue, brain fog, and sleep dysfunction that lasts for at least six months. Accumulating evidence suggests that sex and endocrine events have a significant influence on symptom onset and moderation of ME/CFS, with female sex being one of the most consistent and credible predictive risk factors associated with diagnosis. Such sex differences suggest sex chromosomes and sex steroids may play a part in the development of the condition or moderation of symptoms, although this has yet to be explored in detail. Read More

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The role of growth hormone for fertility in women with hypopituitarism.

Growth Horm IGF Res 2022 Apr 29;63:101458. Epub 2022 Mar 29.

Neurosurgery and Medicine (Endocrinology and Metabolism), Stanford University School of Medicine, 300 Pasteur Drive, Grant-S025, Stanford, CA 94305-5103, United States of America.

Growth hormone (GH) is an important regulator of the female reproductive system. In vitro and non-human in vivo studies demonstrate a role of GH in steroidogenesis, folliculogenesis, and post-fertilization development. Given its ability to modulate the reproductive system and potentiate the effects of gonadotropins, a beneficial role of GH replacement therapy to optimize fertility has been suggested. Read More

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Programming of Vascular Dysfunction by Maternal Stress: Immune System Implications.

Front Physiol 2022 10;13:787617. Epub 2022 Mar 10.

Health Education Research Center (NUPADS), Institute of Health Sciences, Federal University of Mato Grosso, Sinop, Brazil.

A growing body of evidence highlights that several insults during pregnancy impact the vascular function and immune response of the male and female offspring. Overactivation of the immune system negatively influences cardiovascular function and contributes to cardiovascular disease. In this review, we propose that modulation of the immune system is a potential link between prenatal stress and offspring vascular dysfunction. Read More

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Diabetes Mellitus Predicts Weight Gain After Surgery in Patients With Acromegaly.

Front Endocrinol (Lausanne) 2022 9;13:854931. Epub 2022 Mar 9.

Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, South Korea.

Objective: Metabolic complications are common in patients with acromegaly. However, this occasionally does not improve post-surgery and may be related to postoperative weight gain. We aimed to investigate the postoperative weight change and factors associated with postoperative weight gain in patients with acromegaly. Read More

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Reporte de caso: hipoglucemia grave como manifestación tardía de síndrome de Sheehan.

Cir Cir 2022 ;90(2):262-266

Departamento de Ciencias de la Salud, Universidad de Sonora. Ciudad Obregón, Sonora, México.

Background: Sheehan's syndrome is a hypopituitarism secondary to necrosis of the pituitary gland caused by massive postpartum bleeding. The presentation is frequently amenorrhea and agalactia; hypoglycemia as a solitary presentation is uncommon.

Case Report: 68-year-old female with a history of postpartum hemorrhage 35 years ago. Read More

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[Guiding significance of "disease-syndrome-symptom" mode in FU Qing-zhu's Obstetrics and Gynecology (FU Qing-zhu Nyu Ke) for dealing with ovulation disorder infertility caused by hyperprolactinemia].

Zhongguo Zhong Yao Za Zhi 2022 Mar;47(6):1694-1699

Xiyuan Hospital, China Academy of Chinese Medical Sciences Beijing 100091, China.

This paper discussed the guiding significance of "disease-syndrome-symptom" mode in FU Qing-zhu's Obstetrics and Gynecology(FU Qing-zhu Nyu Ke) for dealing with ovulation disorder infertility caused by hyperprolactinemia(HPRL). FU Qing-zhu's Obstetrics and Gynecology(FU Qing-zhu Nyu Ke) concentrates on the disease entities, main symptoms, pathogenesis, and syndrome differentiation, based on which the prescriptions are prescribed. This reflects the "disease-syndrome-symptom" mode, with the core lying in the "combination of disease with syndrome". Read More

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COVID-19 and the Endocrine System: A Review of the Current Information and Misinformation.

Infect Dis Rep 2022 Mar 11;14(2):184-197. Epub 2022 Mar 11.

Department of Internal Medicine, University of New Mexico, Albuquerque, NM 87106, USA.

Coronavirus disease 2019 (COVID-19) infection primarily involves the respiratory system but has many noteworthy extra pulmonary manifestations as well. We write this review to highlight the basis of some pathophysiological mechanisms of COVID-19 infection-induced endocrine dysfunction. Different scientific databases and institutional websites were searched to collect and consolidate the most up-to-date data relating to COVID-19 infection and endocrine systems. Read More

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[Internal medical emergencies in the pregnant patient : Peripartum sepsis, metabolic derailment, endocrinological emergencies and pulmonary edema].

Med Klin Intensivmed Notfmed 2022 Apr;117(3):239-252

Klinik für Anästhesiologie und Intensivmedizin, Klinikum Neumarkt i.d.OPf., Neumarkt i.d.OPf., Deutschland.

Peripartum emergencies that require intensive medical care represent a major challenge for the interdisciplinary treatment team. Due to physiological changes in pregnant women symptoms can be masked and the initiation of treatment is delayed. Peripartum sepsis has a relatively high incidence. Read More

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