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    1189 results match your criteria Pituitary Apoplexy

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    Presenting Symptoms of Pituitary Apoplexy.
    J Neurol Surg A Cent Eur Neurosurg 2017 Apr 24. Epub 2017 Apr 24.
    Department of Internal Medicine, Sotiria General Hospital of Chest Diseases, Athens, Greece.
    The classical term "pituitary apoplexy" (PA) describes a clinical syndrome usually characterized by abrupt onset of headache accompanied by neurologic and/or endocrinologic deterioration due to sudden expansion of a mass within the sella turcica as a result of hemorrhage or infarction within a pituitary tumor and adjacent pituitary gland. PA is a medical emergency and a difficult diagnosis to establish. Thus this article reviews the presenting symptoms of PA patients to help clinicians recognize or at least suspect this critical condition early on. Read More

    Sphenoid sinus mucosal thickening in the acute phase of pituitary apoplexy.
    Pituitary 2017 Apr 18. Epub 2017 Apr 18.
    Department of Neurosurgery, Greater Manchester Neuroscience Centre, Salford Royal Foundation Trust (SRFT), Stott Lane, Salford, M6 8HD, UK.
    Purpose: In pituitary apoplexy (PA), there are preliminary reports on the appearance of sphenoid sinus mucosal thickening (SSMT). SSMT is otherwise uncommon with an incidence of up to 7% in asymptomatic individuals. The aim of this study was to evaluate the incidence and clinical significance of SSMT in patients with PA and a control group of surgically treated non-functioning pituitary adenomas (NFPAs). Read More

    Concomitant Primary CNS Lymphoma and FSH-Pituitary Adenoma Arising Within the Sella. Entirely Coincidental?
    Neurosurgery 2017 Jan;80(1):E170-E175
    Division of Neurosurgery, Addenbroo-ke's Hospital, Cambridge, UK.
    Background And Importance: Collision tumors are the simultaneous occurrence of more than one type of neoplasm within an anatomic space. In the pituitary sella, collision tumors are exceedingly rare, and not much is known about their etiology and prognosis.

    Clinical Presentation: A 74-year-old man presented with a concomitant primary pituitary lymphoma (diffuse large B-cell non-Hodgkin's lymphoma; DLBCL) and follicle-stimulating hormone (FSH)-adenoma diagnosed histologically after clinical features of apoplexy prompted urgent surgical decompression and resection. Read More

    DIAGNOSIS OF ENDOCRINE DISEASE: Expanding the cause of hypopituitarism.
    Eur J Endocrinol 2017 Jun 3;176(6):R269-R282. Epub 2017 Mar 3.
    School of MedicineUniversity of Belgrade, Belgrade, Serbia
    Hypopituitarism is defined as one or more pituitary hormone deficits due to a lesion in the hypothalamic-pituitary region. By far, the most common cause of hypopituitarism associated with a sellar mass is a pituitary adenoma. A high index of suspicion is required for diagnosing hypopituitarism in several other conditions such as other massess in the sellar and parasellar region, brain damage caused by radiation and by traumatic brain injury, vascular lesions, infiltrative/immunological/inflammatory diseases (lymphocytic hypophysitis, sarcoidosis and hemochromatosis), infectious diseases and genetic disorders. Read More

    Presence of headache and headache types in patients with tumors of the sellar region-can surgery solve the problem? Results of a prospective single center study.
    Endocrine 2017 May 27;56(2):325-335. Epub 2017 Feb 27.
    Department of Neurosurgery, University of Duisburg-Essen, Hufelandstr. 55, Essen, 45147, Germany.
    Purpose: Headache is a common presenting feature of patients with pituitary adenomas and other tumors of the sellar region. However, at present, it still is unclear whether the headache is actually caused by the tumor. To explore whether there is a relation, we examined in detail the headache types, their relationship to the underlying pathology, and if the headache responded to neurosurgery in a prospective study design. Read More

    Young adult patient with headache, fever and blurred vision.
    Hormones (Athens) 2016 Oct;15(4):548-550
    Department of Endocrinology and Diabetes, Hellenic Red Cross Hospital, Athens, Greece.
    Background And Importance: This case highlights the fact that acute pituitary apoplexy may be misdiagnosed due to being confused with other entities exhibiting similar symptoms, such as meningitis or subarachnoid hemorrhage.

    Clinical Presentation: A patient in his late 30s presented with sudden and severe frontal headache, fever, blurred vision, nausea, confusion, as well as oculomotor palsy (CN III) with partial ptosis of the left eyelid, dilated left pupil and left eye globe deviation inferiorly and laterally. The final diagnosis was acute pituitary apoplexy complicating a pituitary macroadenoma. Read More

    The impact of surgical timing on visual outcome in pituitary apoplexy: Literature review and case illustration.
    Surg Neurol Int 2017 6;8:16. Epub 2017 Feb 6.
    Department of Neurosciences, Division of Neurosurgery, King Faisal Specialist Hospital and Research Center, Riyadh 11211, Saudi Arabia; Alfaisal University, College of Medicine, Riyadh 11533, Saudi Arabia.
    Background: Neuro-ophthalmologic signs are common clinical manifestations of pituitary apoplexy. Managing sudden visual loss is critical for achieving a good outcome. The timing of pituitary surgery remains controversial. Read More

    Management dilemmas in a rare case of pituitary apoplexy in the setting of dengue hemorrhagic fever.
    Surg Neurol Int 2017 19;8. Epub 2017 Jan 19.
    Department of Neurosurgery, NIMHANS, Bengaluru, Karnataka, India.
    Background: Pituitary apoplexy occurs due to infarction or hemorrhage, within a pituitary adenoma or a nontumorous pituitary gland and can have catastrophic consequences. Dengue hemorrhagic fever (DHF) is a severe manifestation of the spectrum of dengue virus infection and is characterized by high-grade fever, thrombocytopenia, hemorrhagic tendencies, and increased vascular permeability. Cases of incidentalomas complicated by DHF and presenting with apoplexy are extremely rare. Read More

    Multidisciplinary Management of Pituitary Apoplexy.
    Int J Endocrinol 2016 15;2016:7951536. Epub 2016 Dec 15.
    Unit of Endocrinology, Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy.
    Pituitary apoplexy is a rare clinical syndrome due to ischemic or haemorrhagic necrosis of the pituitary gland which complicates 2-12% of pituitary tumours, especially nonfunctioning adenomas. In many cases, it results in severe neurological, ophthalmological, and endocrinological consequences and may require prompt surgical decompression. Pituitary apoplexy represents a rare medical emergency that necessitates a multidisciplinary approach. Read More

    Macroprolactinomas and Nonfunctioning Pituitary Adenomas and Pregnancy Outcomes.
    Obstet Gynecol 2017 Jan;129(1):185-194
    Royal Hampshire County Hospital, Winchester, Hampshire, the Division of Women's Health, King's College London and Queen Charlotte's and Chelsea Hospital, Imperial College Healthcare National Health Service Trust, London, the National Perinatal Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, and the Regional Centre for Endocrinology and Diabetes, Royal Victoria Hospital, Belfast, Northern Ireland, United Kingdom.
    Objective: To examine the monitoring, management, and outcomes of pituitary tumors in pregnancy.

    Methods: A national, prospective, observational, population-based case series study was conducted in all U.K. Read More

    Imaging of the Sella and Parasellar Region.
    Radiol Clin North Am 2017 Jan;55(1):83-101
    Division of Neuroradiology, Department of Radiology, Keck School of Medicine, University of Southern California, 1200 North State Street, Room 3740A, Los Angeles, CA 90033, USA.
    The sella and parasellar region, found between the anterior and central skull base, represents the central aspect of the skull base. Given the location of the pituitary gland in this location, small lesions in this location may have major physiologic effects on the human body. This article reviews the anatomy, development, and pathologic processes that may involve this region. Read More

    Spontaneous Involution of Rathke's Cleft Cysts without Visual Symptoms.
    Brain Tumor Res Treat 2016 Oct 31;4(2):58-62. Epub 2016 Oct 31.
    Department of Neurosurgery, Seoul National University Bundang Hospital, Seongnam, Korea.; Department of Neurosurgery, Seoul National University College of Medicine, Seoul, Korea.
    Background: There have been various reports in the literature regarding the conservative management of pituitary apoplexy, pituitary incidentalomas and Rathke cleft cysts (RCCs). However, to the best of our knowledge, spontaneous involution of cystic sellar mass has rarely been reported. We report 14 cases of cystic sellar masses with spontaneous involution. Read More

    Prolactinoma and pregnancy - a series of cases including pituitary apoplexy.
    J Obstet Gynaecol 2017 Apr 21;37(3):284-287. Epub 2016 Nov 21.
    a Centro Hospitalar do Porto - Centro Materno Infantil do Norte , Porto , Portugal.
    The objective of this article is to evaluate the impact of pregnancy in women with prolactinoma, the possible consequences of therapy maintenance/discontinuation during pregnancy and to assess the type of delivery and maternal-foetal obstetrical outcome. A retrospective study of all pregnant women with prolactinoma in our Centre between 2006 and 2014 was made. We had 35 cases of pregnant women with prolactinoma, two of which had an episode of pituitary apoplexy during the second trimester. Read More

    Pituitary apoplexy masquerading as functional decline in an older person.
    Age Ageing 2017 Mar;46(2):335-336
    Department of Medicine, National University Hospital, Singapore 119074, Singapore.
    We report the case of an older lady who was admitted to a tertiary teaching hospital with sub-acute functional decline of two months' duration, which was initially attributed to a concomitant urinary tract infection. Further investigations, however, revealed the diagnosis of pituitary apoplexy with central hypocortisolism. Subsequent treatment with physiological doses of steroids improved patient's function and overall well-being. Read More

    Complex effects of apoplexy secondary to pituitary adenoma.
    Rev Neurosci 2017 Jan;28(1):59-64
    Pituitary adenoma apoplexy is a well-known clinical syndrome induced by insulin infusion, cardiac surgery, trauma, and hypothalamic releasing factors. Pituitary apoplexy can cause secondary cerebral infarct and internal carotid artery occlusion. With blockade of tumor perfusion, apoplexy triggers a sudden onset of headache, visual impairment, cranial nerve palsy, disturbances of consciousness, eyelid ptosis, and hemiparesis. Read More

    Rathke Cleft Cyst with Evidence of Rupture into Subarachnoid Space.
    World Neurosurg 2017 Jan 21;97:752.e1-752.e3. Epub 2016 Oct 21.
    Department of Neurosurgery, Nara Medical University, Kashihara, Nara, Japan.
    Background: A Rathke cleft cyst (RCC) with nonhemorrhagic rupture mimicking pituitary apoplexy has been reported rarely.

    Case Description: A 52-year-old woman, previously diagnosed with asymptomatic RCC, came to us with a severe headache, along with visual dysfunction and symptoms of pituitary insufficiency. Fluid-attenuated inversion recovery magnetic resonance imaging demonstrated diffuse hyperintensity in the cerebral cisterns, whereas watery clear cerebrospinal fluid was obtained by lumbar puncture. Read More

    Surgical versus non-surgical treatment for pituitary apoplexy: A systematic review and meta-analysis.
    J Neurol Sci 2016 Nov 23;370:258-262. Epub 2016 Sep 23.
    Department of Neurosurgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang Province, China. Electronic address:
    Background: Pituitary apoplexy is a rare disease caused by a sudden hemorrhage into or infarction of the pituitary gland. Its optimal management remains controversial. The aim of this study was to compare the outcomes of surgical and non-surgical treatments for pituitary apoplexy. Read More

    [Cerebral infarction after pituitary apoplexy: Description of a case and review of the literature].
    Neurocirugia (Astur) 2016 Nov - Dec;27(6):310-314. Epub 2016 Jun 2.
    Servicio de Neurocirugía, Hospital Clínico de Santiago de Compostela, Santiago de Compostela, España.
    Pituitary apoplexy is usually the result of hemorrhagic infarction in a pituitary adenoma. The clinical presentation varies widely and includes asymptomatic cases, classical pituitary apoplexy and even sudden death. Cerebral ischemia due to pituitary apoplexy is very rare. Read More

    Pituitary Apoplexy Mimicking Bacterial Meningitis with Intracranial Hypertension.
    World Neurosurg 2017 Jan 15;97:748.e3-748.e5. Epub 2016 Oct 15.
    Department of Neuroradiology, APHP, Pitié-Salpêtrière Hospital, Paris, France; Sorbonne Universités, Pierre and Marie Curie Faculty of Medicine, Paris, France.
    Case Description: A 29-year-old patient experienced a violent headache during bodybuilding exercises. Brain magnetic resonance imaging revealed diffuse meningitis and a 38-mm necrotic pituitary adenoma. Meningoencephalitis was suspected but was ruled out by lumbar puncture. Read More

    Acute vision loss in post-partum period as presenting symptom of HIV-associated cryptococcal meningitis-an unusual case report.
    BMC Infect Dis 2016 Oct 19;16(1):582. Epub 2016 Oct 19.
    Department of Neurology, King George Medical University, Lucknow, PIN-226003, Uttar Pradesh, India.
    Background: Acute vision loss in the post-partum period can occur due to many reasons. Eclampsia, posterior reversible encephalopathy syndrome (PRES), pituitary apoplexy, and central serous retinopathy are some of the important causes. Cryptococcal meningitis as a cause of acute vision loss in the post-partum period has not been mentioned in literature. Read More

    A pediatric case of pituitary macroadenoma presenting with pituitary apoplexy and cranial nerve involvement: case report.
    Turk Pediatri Ars 2016 Sep 1;51(3):162-165. Epub 2016 Sep 1.
    Department of Neurosurgery, Bülent Ecevit University School of Medicine, Zonguldak, Turkey.
    Pituitary adenomas usually arise from the anterior lobe of the pituitary gland and are manifested with hormonal disorders or mass effect. Mass effect usually occurs in nonfunctional tumors. Pituitary adenomas may be manifested with visual field defects or rarely in the form of total oculomotor palsy. Read More

    Unusual Complication of Pituitary Macroadenoma: A Case Report and Review.
    Am J Case Rep 2016 Oct 6;17:707-711. Epub 2016 Oct 6.
    Department of Clinical Imaging, Hamad General Hospital, Hamad Medical Corporation, Doha, Qatar.
    BACKGROUND Pituitary macroadenoma is a common benign tumor that usually presents with visual field defects or hormonal abnormalities. Cerebral infarction can be a complication of a large pituitary adenoma. We report a rare case of bilateral anterior cerebral arteries infarcts by a large pituitary macroadenoma with apoplexy. Read More

    Approach to the management of rare clinical presentations of macroprolactinomas in reproductive-aged women.
    Case Rep Womens Health 2015 Oct 24;8:9-12. Epub 2015 Sep 24.
    Division of Endocrinology, Diabetes, Metabolism, and Nutrition, 200 First Street SW, Mayo Clinic, Rochester, MN, 55905, United States.
    Objective: To describe 2 cases of macroprolactinomas with atypical presentation in women desiring pregnancy that illustrate important considerations in the management approach for macroprolactinomas in reproductive-aged women.

    Patients: Case 1 was a 26-year-old woman referred to our institution for possible tumor resection after pituitary apoplexy during her first pregnancy. Instead, she underwent treatment with cabergoline for a year with goals of normalization of prolactin and decrease in tumor size to <1 cm before trying to conceive. Read More

    Time Course of Symptomatic Recovery After Endoscopic Transsphenoidal Surgery for Pituitary Adenoma Apoplexy in the Modern Era.
    World Neurosurg 2016 Dec 20;96:434-439. Epub 2016 Sep 20.
    Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
    Background: Pituitary tumor apoplexy can result from either hemorrhagic or infarctive expansion of pituitary adenomas, and the related mass effect can result in compression of critical neurovascular structures. The time course of recovery of visual field deficits, headaches, ophthalmoparesis, and pituitary dysfunction after endoscopic transsphenoidal surgery has not been well established.

    Methods: Medical records were retrospectively reviewed for all patients who underwent endoscopic transsphenoidal surgery for pituitary tumor apoplexy from April 2008 to November 2014. Read More

    PITUITARY APOPLEXY DUE TO DAIGNOSTIC TEST IN CUSHING'S DISEASE PATIENT.
    Turk Neurosurg 2016 Feb 5. Epub 2016 Feb 5.
    Bulent Ecevit University, Faculty of Medicine.
    Pituitary apoplexy is a medical condition that needs urgent diagnosis and treatment. It may occur spontaneously or may be precipitated by a variety of reasons including dynamic endocrine tests. Although pituitary apoplexy is usually seen in non-functional pituitary adenoma, it can also be seen in ACTH secreting macroadenomas. Read More

    Pituitary Apoplexy After Initial Leuprolide Injection.
    World Neurosurg 2016 Nov 29;95:616.e7-616.e9. Epub 2016 Aug 29.
    Department of Medical Oncology, Roswell Park Cancer Institute, Buffalo, New York, USA; Department of Medicine, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, New York, USA.
    Background: Pituitary apoplexy is a rare complication of the initial administration of leuprolide acetate.

    Case Description: We present the case of a 63-year-old man who experienced headache, blurred vision, and loss of consciousness after initial leuprolide treatment for prostate carcinoma. Neuroimaging showed pituitary hemorrhage. Read More

    A review on the diagnosis and treatment of patients with clinically nonfunctioning pituitary adenoma by the Neuroendocrinology Department of the Brazilian Society of Endocrinology and Metabolism.
    Arch Endocrinol Metab 2016 Aug;60(4):374-90
    Serviço de Endocrinologia, Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro (HUCFF-UFRJ), Rio de Janeiro, RJ, Brasil.
    Clinically nonfunctioning pituitary adenomas (NFPA) are the most common pituitary tumors after prolactinomas. The absence of clinical symptoms of hormonal hypersecretion can contribute to the late diagnosis of the disease. Thus, the majority of patients seek medical attention for signs and symptoms resulting from mass effect, such as neuro-ophthalmologic symptoms and hypopituitarism. Read More

    Pituitary tuberculoma: A consideration in the differential diagnosis in a patient manifesting with pituitary apoplexy-like syndrome.
    IDCases 2016 29;5:63-6. Epub 2016 Jul 29.
    Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand.
    Pituitary tuberculoma is extremely rare, even in endemic regions of tuberculosis and much less frequently as a presentation of pituitary apoplexy. We describe a 25-year-old female presented with sudden onset of headache and vision loss of left eye which mimicking symptoms of pituitary apoplexy. MRI of the pituitary gland showed a rim-enhancing lesion at the intrasellar region extending into the suprasellar area, but absence of posterior bright spot with enhancement of the pituitary stalk. Read More

    Pituitary apoplexy in pregnancy: A case series and literature review.
    Obstet Med 2015 Dec 22;8(4):177-83. Epub 2015 Sep 22.
    Endocrinology Division, Department of Medicine, Centre de Recherche du Centre hospitalier de l'Université de Montréal (CR-CHUM), Montreal, QC, Canada.
    Background: Severe headache during pregnancy is a challenging condition that may rarely imply endocrine disturbances. Rapid recognition of pituitary apoplexy is needed to improve pregnancy outcome.

    Objective: To review and compare maternal and fetal outcomes after pituitary apoplexy. Read More

    Subarachnoid hemorrhage caused by an undifferentiated sarcoma of the sellar region.
    Surg Neurol Int 2016 7;7(Suppl 16):S459-62. Epub 2016 Jul 7.
    Department of Diagnostic Pathology, Fujita Health University Hospital, Toyoake, Japan.
    Background: It is rare for patients with pituitary apoplexy to exhibit concomitant subarachnoid hemorrhage (SAH). Only a handful of patients with pituitary apoplexy have developed such hemorrhagic complications, and histopathological examination revealed pituitary adenoma as the cause of SAH.

    Case Report: A previously healthy 35-year-old woman was brought to our institution after complaining of severe headache and left monocular blindness. Read More

    Primary immune thrombocytopenia accompanied by pituitary apoplexy.
    Rinsho Ketsueki 2016 Jul;57(7):877-80
    Department of Hematology and Oncology, Kumamoto City Hospital.
    An 83-year-old woman was admitted to our hospital with a severe headache and purpura. She had previously been diagnosed with idiopathic thrombocytopenia purpura (ITP) and achieved complete remission with steroid therapy. Steroid therapy had been completed one week prior to the current admission. Read More

    Ischemic pituitary adenoma apoplexy-Clinical appearance and prognosis after surgical intervention.
    Clin Neurol Neurosurg 2016 Sep 7;148:142-6. Epub 2016 Jul 7.
    Department of Neurosurgery, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan, Japan.
    Background: Several retrospective investigations have recommended more passive surgical indications for intratumoral hemorrhage of pituitary adenomas due to probable spontaneous resolution. However, no definitive analyses have compared pituitary adenomas with hemorrhagic apoplexy and intratumoral hemorrhage without evident apoplectic symptoms or pituitary adenoma infarction.

    Methods: This study retrospectively identified 43 patients with symptomatic pituitary apoplexy among 1067 patients with pituitary adenomas initially treated by surgery at a single institute between April 2005 and May 2015, with 27 cases of hemorrhagic (2. Read More

    Neuro-Ophthalmology Cases for the Neurologist.
    Neurol Clin 2016 Aug;34(3):611-29
    Department of Ophthalmology, Blanton Eye Institute, Houston Methodist Hospital, 6560 Fannin Street, Scurlock 450, Houston, TX 77030, USA; Department of Ophthalmology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555, USA; Department of Ophthalmology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA; Department of Ophthalmology, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065, USA; Department of Neurology, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065, USA; Department of Neurosurgery, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065, USA; Section of Ophthalmology, UT MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA. Electronic address:
    Neurologists should be aware of specific urgent and emergent neuro-ophthalmic conditions, including giant cell arteritis, arterial dissection, intracranial aneurysm, pituitary apoplexy, and invasive sino-orbital fungal infection (eg, mucormycosis). Early recognition and treatment can greatly impact patient morbidity and mortality, including the preservation of vision and life. Neurologists should be cognizant of the key and differentiating clinical and radiographic features for these presentations. Read More

    Third, Fourth, and Sixth Cranial Nerve Palsies in Pituitary Apoplexy.
    World Neurosurg 2016 Oct 17;94:447-452. Epub 2016 Jul 17.
    Department of Ophthalmology, Emory University, Atlanta, Georgia, USA; Department of Neurology, Emory University, Atlanta, Georgia, USA; Department of Epidemiology, Emory University, Atlanta, Georgia, USA. Electronic address:
    Background: Pituitary apoplexy (PA) often presents with acute headache and neuro-ophthalmic manifestations, including ocular motility dysfunction (OMD) from cranial nerve palsies (CNPs). Our goal was to describe the epidemiology and outcomes of OMD in a large, single-center series of patients with PA.

    Methods: We conducted a retrospective chart review of all patients with PA seen in our pituitary center between January 1995 and December 2012. Read More

    A primer on pituitary injury for the obstetrician gynecologist: Simmond's disease, Sheehan's Syndrome, traumatic injury, Dahan's Syndrome, pituitary apoplexy and lymphocytic hypophysitis.
    Minerva Ginecol 2017 Apr 13;69(2):190-194. Epub 2016 Jul 13.
    McGill Reproductive Center, McGill University, Royal Victoria Hospital, Montreal, Canada.
    The pituitary gland plays a critical role in reproduction. In response to the hypothalamus the anterior pituitary secretes prolactin, thyroid-stimulating hormone, adreno-corticotropic hormone, follicle-stimulating hormone, luteinizing hormone and growth hormone. Dysregulation in these hormones often lead to reproductive failure. Read More

    Ventriculitis from a pituitary prolactinoma: bacterial or chemical?
    Br J Neurosurg 2017 Apr 11;31(2):262-263. Epub 2016 Jul 11.
    a Department of Neurosurgery , Royal Victoria Hospital , Newcastle upon Tyne , UK.
    We report the case of a 70-year-old man presenting with pituitary apoplexy from a macroprolactinoma and ventriculitis. It was not possible to distinguish a bacterial or chemical origin, on the basis of his clinical presentation, laboratory studies and imaging, highlighting the importance of prompt imaging and attainment of CSF cultures, in making the diagnosis. Read More

    Surgical management of acromegaly: Long term functional outcome analysis and assessment of recurrent/residual disease.
    Asian J Neurosurg 2016 Jul-Sep;11(3):261-7
    Department of Neurosurgery, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.
    Context: Functional growth hormone producing adenomas have long-term deleterious effects on the visual apparatus, the cardiovascular and musculoskeletal systems, and often predispose to malignancies. Since persistence of acromegaly affects outcome and quality of life, therapeutic interventions become mandatory.

    Aim: This study represents an analysis of long-term clinical and endocrinal outcome of 115 patients of acromegaly after surgical management. Read More

    Pituitary Apoplexy Associated with Carotid Compression and a Large Ischemic Penumbra.
    World Neurosurg 2016 Aug 16;92:581.e7-581.e13. Epub 2016 Jun 16.
    Department of Neurosurgery, Stanford University School of Medicine, Stanford, California, USA.
    Background: Pituitary apoplexy is an acute clinical syndrome caused by pituitary gland hemorrhage or infarction. Rarely, this clinical syndrome is associated with cerebral infarction secondary to compression of an internal carotid artery. We report an unusual case of pituitary apoplexy associated with a cerebral infarct with a large ischemic penumbra. Read More

    How should we interrogate the hypothalamic-pituitary-adrenal axis in patients with suspected hypopituitarism?
    BMC Endocr Disord 2016 Jun 17;16(1):36. Epub 2016 Jun 17.
    Division of Endocrinology, Beaumont Hospital, Dublin, Ireland.
    Hypopituitarism is deficiency of one or more pituitary hormones, of which adrenocorticotrophic hormone (ACTH) deficiency is the most serious and potentially life-threatening. It may occur in isolation or, more commonly as part of more widespread pituitary failure. Diagnosis requires demonstration of subnormal cortisol rise in response to stimulation with hypoglycemia, glucagon, ACTH(1-24) or in the setting of acute illness. Read More

    Gonadotropin-releasing hormone agonist-induced pituitary apoplexy.
    Endocrinol Diabetes Metab Case Rep 2016 8;2016:160021. Epub 2016 Jun 8.
    Department of Endocrinology, University Hospital Galway, Newcastle, Galway, Ireland; School of Medicine, National University of Ireland Galway, Newcastle, Galway, Ireland.
    Unlabelled: Pituitary apoplexy represents an uncommon endocrine emergency with potentially life-threatening consequences. Drug-induced pituitary apoplexy is a rare but important consideration when evaluating patients with this presentation. We describe an unusual case of a patient with a known pituitary macroadenoma presenting with acute-onset third nerve palsy and headache secondary to tumour enlargement and apoplexy. Read More

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