38,882 results match your criteria Pituitary Adenoma


Diabetes insipidus complicating apoplexy during pregnancy: the potential use of copeptin.

Intern Med J 2020 Jul;50(7):877-879

Adult Endocrinology, Royal Adelaide Hospital, Adelaide, South Australia, Australia.

Pituitary apoplexy during pregnancy is rare but important to recognise, particularly in the hyperoestrogenaemic state when known lactotroph hyperplasia occurs. Untreated, the complication rates from pituitary adenomas depend upon the size of the adenoma before pregnancy. A history of thirst plus polydipsia during pregnancy raises suspicion for diabetes insipidus and a 24-h urine collection quantifying polyuria with an inappropriately low urine osmolality confirms the diagnosis. Read More

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http://dx.doi.org/10.1111/imj.14918DOI Listing

Cell proliferation, apoptosis, and angiogenesis in non-functional pituitary adenoma: association with tumor invasiveness.

Endocrine 2020 Jul 12. Epub 2020 Jul 12.

Department of Endocrinology, Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, University of Oxford, Oxford, UK.

Purpose: Non-functioning pituitary adenoma (NFPA) is the most prevalent pituitary macroadenoma. No prognostic marker has been found to explain the behavior of these tumors. We aimed to explore cell proliferation, apoptosis, proangiogenic markers, and microvascular density (MVD) in noninvasive and invasive NFPAs. Read More

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http://dx.doi.org/10.1007/s12020-020-02366-6DOI Listing

Decrease of Proliferative Potential and Vascular Density of Giant Prolactinoma in Patients Treated with Cabergoline.

Asian J Neurosurg 2020 Apr-Jun;15(2):385-390. Epub 2020 May 29.

N.N. Burdenko National Medical Research Center of Neurosurgery, Moscow, Russia.

Introduction: Currently, cabergoline therapy is the main treatment for prolactinomas. The use of the drug in most cases leads to regression of the tumor, normalization of prolactin (PRL) levels, and restoration of gonadotropic function. The mechanism of its action in tumor cells "" tracked in dynamics in the same human tumor is of considerable interest. Read More

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http://dx.doi.org/10.4103/ajns.AJNS_16_20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7335146PMC

The immune profile of pituitary adenomas and a novel immune classification for predicting immunotherapy responsiveness.

J Clin Endocrinol Metab 2020 Jul 12. Epub 2020 Jul 12.

Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, P. R. China.

Context: The tumor immune microenvironment is associated with clinical outcomes and immunotherapy responsiveness.

Objective: To investigate the intratumoral immune profile of pituitary adenomas (PAs) and its clinical relevance and to explore a novel immune classification for predicting immunotherapy responsiveness.

Design, Patients And Methods: The transcriptomic data from 259 PAs and 20 normal pituitaries were included for analysis. Read More

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http://dx.doi.org/10.1210/clinem/dgaa449DOI Listing

Combined and simultaneous endoscopic endonasal and transorbital surgery for a Meckel's cave schwannoma: technical nuances of a mini-invasive, multiportal approach.

J Neurosurg 2020 Jul 10:1-10. Epub 2020 Jul 10.

Departments of1Neurological Surgery and.

Objective: Over the years, Meckel's cave pathologies have been judged off-limits because of high rates of morbidity. Even though several studies have defined various surgical routes with tolerable morbidity and mortality rates, controversies related to the optimal avenue to treat different categories of Meckel's cave and cavernous sinus neoplasms persist.With unceasing energy to cultivate minimally invasive neurosurgical approaches, the endoscopic endonasal route has been tested, and the approach effectively performed, to provide a valid surgical window to these areas. Read More

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http://dx.doi.org/10.3171/2020.4.JNS20707DOI Listing

[Radiation-induced meningiomas: analysis of 33 cases].

Zh Vopr Neirokhir Im N N Burdenko 2020 ;84(3):53-60

Burdenko Neurosurgical Center, Moscow, Russia.

Background: Development of meningiomas correlating with irradiation has been described in the last century. Different biological features of radiation-induced meningiomas depending on dose and type of irradiation have been observed in recent years.

Material And Methods: There were 8848 patients (women - 74. Read More

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http://dx.doi.org/10.17116/neiro20208403153DOI Listing
January 2020

MiR-448 targets BLC2 and inhibits the growth of pituitary adenoma cells.

Biochem Cell Biol 2020 Jul 10:1-7. Epub 2020 Jul 10.

Institute of Cardiology, China Three Gorges University, Yichang, Hubei 443003, P.R. China.

There is an increasing body of evidence indicating the important roles of miRNAs in the progression of pituitary adenoma. Recent studies have shown decreased expression and tumor suppressive function of miR-448 in cancers; however, the clinical significance of miR-448 in pituitary adenoma has remained largely unknown. In our study, we found that miR-448 was down-regulated in pituitary adenoma tissues and cell lines. Read More

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http://dx.doi.org/10.1139/bcb-2019-0336DOI Listing

Mortality of Patients with Cushing's Disease.

Exp Clin Endocrinol Diabetes 2020 Jul 9. Epub 2020 Jul 9.

Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom of Great Britain and Northern Ireland.

Cushing's disease is a rare condition of cortisol excess attributed to a pituitary adenoma with an annual incidence of 1.2-2.4 cases per million population. Read More

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http://dx.doi.org/10.1055/a-1197-6380DOI Listing

Morphometric Alterations of the Sphenoid Ostium and other Landmarks in Acromegaly: Anatomical Considerations and Implications in Endoscopic Pituitary Surgery.

Neurol India 2020 May-Jun;68(3):573-578

Department of Neurological Sciences, Sri Sathya Sai Institute of Higher Medical Sciences, Bengaluru, Karnataka, India.

Background: The sphenoid ostium (SO) is an important landmark for the endoscopic surgeon. Changes in size and position of the SO and variations in other skull base landmarks in acromegalics have not been adequately evaluated.

Aims: The authors evaluated the morphometry and location of the SO and other landmarks in acromegaly and compared these findings with those in nonfunctioning pituitary adenomas (NFPAs). Read More

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http://dx.doi.org/10.4103/0028-3886.288996DOI Listing

Report of intradural aneurysm in the cavernous segment of the internal carotid artery presented with subarachnoid hemorrhage and oculomotor palsy.

Surg Neurol Int 2020 13;11:149. Epub 2020 Jun 13.

Department of Neurosurgery, Santa Casa de Sao Paulo School of Medical Sciences, Sao Paulo, Brazil.

Background: Aneurysms of the cavernous segment of the internal carotid artery (ICA) do not usually cause subarachnoid hemorrhage (SAH). We report a patient who presented with this condition due to a ruptured aneurysm located on the posterior genu of the cavernous segment, raising the question of what factors could have led to such evolution.

Case Description: A 55-year-old male patient presented with sudden, intense thunderstorm headache, associated with complete palsy of the left oculomotor nerve and neck stiffness. Read More

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http://dx.doi.org/10.25259/SNI_105_2020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7332490PMC

Spinal epidural lipomatosis with osteoporotic vertebral fracture presenting as acute thoracic myelopathy in a 33-year-old man with Cushing's disease.

World Neurosurg 2020 Jul 4. Epub 2020 Jul 4.

Department of Otolaryngology, Sir HN Reliance Foundation Hospital and Research Center, Mumbai, Maharashtra, India.

Background: Steroid-related spinal epidural lipomatosis (SEL) is a well-known condition most commonly encountered in patients taking chronic steroid medications. Endogenous Cushing's syndrome is a rare cause of SEL. The authors report an unusual presentation of acute thoracic myelopathy due to SEL with osteoporotic vertebral compression fractures in a patient with Cushing's disease. Read More

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http://dx.doi.org/10.1016/j.wneu.2020.06.212DOI Listing

Germinal defects of SDHx genes in patients with isolated pituitary adenoma.

Eur J Endocrinol 2020 Jul 1. Epub 2020 Jul 1.

P Romanet, INSERM, MMG, Laboratory of Molecular Biology Hospital La Conception, Aix Marseille Univ, Marseille, France.

Introduction: TThe '3PAs' syndrome, associating pituitary adenoma (PA) and pheochromocytoma/paraganglioma (PPGL), is sometimes associated with mutations in PPGL-predisposing genes such as SDHx or MAX. In '3PAs' syndrome, PAs can occur before PPGL, suggesting a new gateway into SDHx/MAX-related diseases.

Objective: To determine the SDHx/MAX mutation prevalence in patients with isolated PAs and characterize PAs of patients with SDHx/MAX mutations. Read More

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http://dx.doi.org/10.1530/EJE-20-0054DOI Listing

Cyclin A in nonfunctioning pituitary adenomas.

Endocrine 2020 Jul 3. Epub 2020 Jul 3.

Neuroendocrinology Research Center/ Endocrinology Division, Medical School and Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.

Purpose: Assess cyclin A in nonfunctioning pituitary adenomas (NFPA) and compare its expression in non-invasive and non-proliferative tumors with invasive and proliferative tumors (12× higher risk of recurrence).

Methods: Quantitative real time polymerase chain reaction to analyze cyclin A using normal pituitary gland as reference. Fold change (FC) > 1 was considered as increased. Read More

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http://dx.doi.org/10.1007/s12020-020-02402-5DOI Listing

Radiographic and clinical outcomes using intraoperative magnetic resonance imaging for transsphenoidal resection of pituitary adenomas.

J Neurosurg 2020 Jul 3:1-12. Epub 2020 Jul 3.

Departments of2Neurosurgery.

Objective: The utility and safety of intraoperative MRI (iMRI) for resection of pituitary adenomas is not clearly established in the context of advances in endoscopic approaches. The goal in this study was to evaluate the safety and efficacy of iMRI for pituitary adenoma resection, with endoscopic transsphenoidal (ETS) versus microscopic transsphenoidal (MTS) approaches.

Methods: Radiographic and clinical outcomes of all pituitary adenomas resected using iMRI between 2008 and 2017 at a single institution were retrospectively evaluated. Read More

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http://dx.doi.org/10.3171/2020.4.JNS20178DOI Listing

Association of PTP4A3 expression and tumour size in functioning pituitary adenoma: a descriptive study.

J Clin Pathol 2020 Jul 2. Epub 2020 Jul 2.

Instituto de Investigaciones en Ciencias de la Salud (INICSA), Centro de Microscopia Electronica-Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Cordoba, Argentina

Background: PTP4A3 is a subclass of a protein tyrosine phosphatase super family and is expressed in a range of epithelial neoplasms. We evaluated PTP4A3 expression and its association with clinicopathological parameters in different types of functioning pituitary adenomas.

Methods: A total of 34 functioning pituitary adenomas samples were evaluated in this observational study. Read More

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http://dx.doi.org/10.1136/jclinpath-2020-206728DOI Listing

Epidemiology of Functioning Pituitary Adenomas.

Authors:
Sang Ouk Chin

Endocrinol Metab (Seoul) 2020 Jun 24;35(2):237-242. Epub 2020 Jun 24.

Department of Endocrinology and Metabolism, Kyung Hee University College of Medicine, Seoul, Korea.

Pituitary adenomas (PAs) are defined as benign monoclonal tumors in the pituitary gland that cause symptoms due to either hormonal hypersecretion or a space-occupying effect, and are classified as functioning or non-functioning. Because of their rarity and slow-growing with symptomless nature in most cases, it has been challenging to investigate the epidemiology of PAs. Considering their public health impact and association with increased morbidity and mortality, however, it is essential to understand the prevalence and incidence of PAs in order to improve patient outcomes and to minimize the resultant burden on the health care system. Read More

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http://dx.doi.org/10.3803/EnM.2020.35.2.237DOI Listing

Precision Therapy in Acromegaly Caused by Pituitary Tumors: How Close Is It to Reality?

Endocrinol Metab (Seoul) 2020 Jun 24;35(2):206-216. Epub 2020 Jun 24.

Division of Endocrinology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.

Acromegaly presents with an enigmatic range of symptoms and comorbidities caused by chronic and progressive growth hormone elevations, commonly due to endocrinologic hypersecretion from a pituitary gland tumor. Comprehensive national acromegaly databases have been appearing over the years, allowing for international comparisons of data, although still presenting varying prevalence and incidence rates. Lack of large-scale analysis in geographical and ethnic differences in clinical presentation and management requires further research. Read More

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http://dx.doi.org/10.3803/EnM.2020.35.2.206DOI Listing

Adenohypophyseal hyperfunction syndromes and posterior pituitary tumors: prevalence, clinical characteristics, and pathophysiological mechanisms.

Endocrine 2020 Jul 1. Epub 2020 Jul 1.

Departments of Endocrinology, Hospital Universitario Puerta de Hierro Majadahonda, Madrid, Spain.

Posterior pituitary tumors are rare nonneuroendocrine neoplasms originating in the neurohypophysis that lack hormonal secretory capacity. Surprisingly, these tumors are relatively frequently associated with adenohypophyseal syndromes of hormonal hypersecretion such as Cushing's disease and acromegaly. Fifteen cases of posterior pituitary tumor associated with hypercortisolism have been reported to date, 13 of them were pituicytomas (Pi) and 2 were granular cell tumors (GCT). Read More

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http://dx.doi.org/10.1007/s12020-020-02399-xDOI Listing

Sellar Pathologies Mimicking Pituitary Tumors.

Neurol India 2020 May-Jun;68(Supplement):S154-S160

Department of Neurosurgery, Bombay Hospital Institute of Medical Sciences, Mumbai, Maharashtra, India.

The most common sellar pathology that merits neurosurgical attention is the pituitary adenoma. However, some developmental, inflammatory, and neoplastic lesions may primarily or secondarily involve the sella, mimicking pituitary tumors. Advances in imaging and endocrinological assessment have helped in the recognition of these less common sellar, supra sellar pathologies, which may occasionally create confusion in management. Read More

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http://dx.doi.org/10.4103/0028-3886.287682DOI Listing

Status of Pituitary Surgery During the COVID-19 Pandemic.

Neurol India 2020 May-Jun;68(Supplement):S134-S136

Department of Neurosurgery, Emory University, USA.

Even in ideal circumstances, the performance of safe and effective endoscopic transsphenoidal pituitary surgery requires complicated orchestration of care amongst multiple medical and surgical teams in the preoperative, intraoperative, and postoperative settings. The current COVID-19 pandemic further complicates this highly orchestrated effort. Healthcare systems around the globe are working to adapt to the rapidly changing healthcare landscape as information about the SARS-CoV-2 virus is discovered and disseminated. Read More

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http://dx.doi.org/10.4103/0028-3886.287685DOI Listing

Role of Stereotactic Radiosurgery in Pituitary Adenomas.

Neurol India 2020 May-Jun;68(Supplement):S123-S128

Department of Neurosurgery, All India Institute of Medical Sciences, New Delhi, India.

Pituitary adenomas are one of the common indications for gamma knife radiosurgery. Gamma knife enables one to deliver a very high radiation dose to the target in a single fraction. Due to steep radiation fall out of Gamma Knife, the adjacent visual apparatus gets minimal radiation. Read More

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http://dx.doi.org/10.4103/0028-3886.287674DOI Listing

Modern Radiation Therapy for Pituitary Adenoma: Review of Techniques and Outcomes.

Neurol India 2020 May-Jun;68(Supplement):S113-S122

Department of Radiation Oncology; Department of Neuro-Oncology Disease Management Group, TMH/ACTREC, Tata Memorial Centre, Homi Bhabha National Institute (HBNI), Mumbai, Maharashtra, India.

Pituitary adenomas are benign tumors arising in the adenohypophysis and comprise 8%-20% of all reported primary brain tumors in the west. Transsphenoidal surgery with an aim to achieve complete tumor resection is the recommended first-line treatment for nonfunctioning as well as secretory pituitary adenoma. External beam radiation therapy (RT) has been demonstrated to be an effective treatment modality for pituitary adenoma, uncured by surgery and/or medical therapy, providing excellent long-term local control (>90%), but lower and variable rates (50%-80%) of biochemical remission in secretory tumors. Read More

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http://dx.doi.org/10.4103/0028-3886.287678DOI Listing

Postoperative Hormonal Outcomes in Patients with Large and Giant Non-functioning Pituitary Adenomas.

Neurol India 2020 May-Jun;68(Supplement):S106-S112

Department of Neurological Sciences, Christian Medical College, Vellore, Tamil Nadu, India.

Objective And Aims: To study hormonal axis (HA) dysfunction pre-operatively and at three months after surgery in patients with large (>3 cms) (Hardy's grade C) and giant (>4 cms) nonfunctioning pituitary adenomas (NFPA).

Methods: One hundred thirty nine patients operated between 2006 and 2017, with 3 months post-operative hormonal evaluation, were included in this retrospective study. HA damage was categorized as 0 to 3 based on number of axes (thyrotroph, corticotroph and gonadotroph) that were affected. Read More

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http://dx.doi.org/10.4103/0028-3886.287670DOI Listing

The Importance of Long Term Follow Up After Endoscopic Pituitary Surgery: Durability of Results and Tumor Recurrence.

Neurol India 2020 May-Jun;68(Supplement):S92-S100

Division of Neurosurgery, Department of Surgery, Toronto Western Hospital, University of Toronto, Toronto, ON, Canada.

Introduction: Endoscopic endonasal approach (EEA) has become the preferred surgical approach for resection of pituitary adenomas in most centers. This technique has a number of advantages such as improved visualization and maneuverability, when compared to microscopic transsphenoidal approach. However, the long-term results of this approach are still scarce. Read More

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http://dx.doi.org/10.4103/0028-3886.287675DOI Listing

Recent Developments in Endoscopic Endonasal Approach for Pituitary Adenomas.

Neurol India 2020 May-Jun;68(Supplement):S79-S84

Professor, Department of Neurosurgery, All India Institute of Medical Sciences, New Delhi, India.

Background: Endoscopic endonasal transsphenoidal approach has become the workhorse for pituitary adenomas. The residual rates and complications continue to present as challenges for the pituitary surgeons.

Objective: To review the recent developments in endoscopic pituitary surgeries for improving patient outcomes and safety rates. Read More

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http://dx.doi.org/10.4103/0028-3886.287671DOI Listing

Pituitary Apoplexy: A Comprehensive Review.

Neurol India 2020 May-Jun;68(Supplement):S72-S78

Department of Neurosurgery, Devadoss Hospital, Madurai, Tamil Nadu, India.

Pituitary apoplexy (PA) is a rare, usually vision-threatening and occasionally life-threatening entity. The exact incidence of PA in large series of pituitary adenomas is variable; however, it is more common in macroadenomas and nonfunctioning adenomas though it has been reported rarely in microadenomas. There are several well-known precipitating factors for PA including the use of anticoagulants, surgery, head trauma, pregnancy, etc. Read More

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http://dx.doi.org/10.4103/0028-3886.287669DOI Listing

Surgery for Acromegaly.

Neurol India 2020 May-Jun;68(Supplement):S44-S51

Section of Neurosurgery, Department of Neurological Sciences, Christian Medical College, Vellore, Tamil Nadu, India.

Growth hormone (GH) hypersecretion from a pituitary adenoma results in acromegaly, an endocrinological disorder with multiple systemic manifestations that presents several unique challenges in terms of perioperative management and long term outcomes. Current guidelines provide stringent criteria for determining biochemical remission, necessitating an aggressive approach to management. Despite the development of several non-surgical therapies, transsphenoidal surgery, the endoscopic approach in particular, remains the primary line of treatment for rapid normalization of GH and Insulin-like growth factor with a low incidence of perioperative morbidity. Read More

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http://dx.doi.org/10.4103/0028-3886.287664DOI Listing

Current Status of Diagnosis and Management for Functioning Pituitary Tumors: Part I.

Neurol India 2020 May-Jun;68(Supplement):S13-S19

Department of Endocrinology, Seth G.S. Medical College and KEM Hospital, Mumbai, Maharashtra, India.

Pituitary adenomas (PA) account for approximately 15% of all intracranial neoplasms. Pituitary adenomas can be of different subtypes based on the cell of origin or associated hormone hypersecretion (non-functioning pituitary adenoma, prolactinoma, somatotropinoma, corticotropinoma, thyrotropinoma, and gonadotropinoma). Functioning PAs are associated with relatively higher morbidity and mortality because of associated hormone hypersecretion syndromes. Read More

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http://dx.doi.org/10.4103/0028-3886.287680DOI Listing

Newer Concepts in the Classification of Pituitary Adenomas.

Neurol India 2020 May-Jun;68(Supplement):S7-S12

Department of General Pathology, Christian Medical College, Vellore, Tamil Nadu, India.

The classification of tumors of the pituitary gland has seen several changes in recent years. The 4 edition of the World Health Organization Classification of Tumours of Endocrine Organs, published in 2017, saw the introduction of a classification based on cell lineage using immunohistochemistry for both pituitary specific hormones as well as pituitary specific transcription factors. The term "hormone-producing" was thus replaced by "-troph. Read More

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http://dx.doi.org/10.4103/0028-3886.287667DOI Listing

MEN Type I (Wermer Syndrome).

J Assoc Physicians India 2020 May;68(5):51-52

PG Student, RNT Medical College, Udaipur, Rajasthan.

MEN I inherited as an autosomal dominant disorder leads to hyperplastic/ neoplastic changes in parathyroid, pituitary and endocrine pancreas along with other characteristic tumours. Hyperparathyroidism is the most common manifestation of MEN I. Our case was a female patient aged 42 years who was diagnosed with parathyroid adenoma, coincident with pancreatic neoplasm and adrenal adenoma. Read More

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The slope of the learning curve in 600 consecutive endoscopic transsphenoidal pituitary surgeries.

Acta Neurochir (Wien) 2020 Jul 1. Epub 2020 Jul 1.

Department of Neurosurgery, Weill Cornell Medicine, New York-Presbyterian Hospital, New York, NY, USA.

Background: Endonasal endoscopic transsphenoidal surgery (EETS) for pituitary adenoma has become a mainstay of treatment over the last two decades and it is generally accepted that once this learning curve is achieved, a plateau is reached with little incremental improvement.

Objective: The objective of this study was to assess the slope of the learning curve over a long period of time for a variety of outcomes measures.

Methods: We examined outcomes and complications in a consecutive series of 600 EETS for pituitary adenoma grouped into quartiles based on date of surgery. Read More

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http://dx.doi.org/10.1007/s00701-020-04471-xDOI Listing

Isolated second-phase diabetes insipidus post-transsphenoidal surgery.

BMJ Case Rep 2020 Jun 30;13(6). Epub 2020 Jun 30.

Department of Diabetes and Endocrinology, Mater Dei Hospital, Msida, Malta.

A 57-year-old woman presented with severe lethargy, dizziness and nausea 1 week after transsphenoidal resection of a growth hormone secreting pituitary adenoma. She was found to have severe hyponatremia of 115 mmol/L. Importantly, she was neurologically intact and clinically euvolaemic. Read More

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http://dx.doi.org/10.1136/bcr-2020-235499DOI Listing

Pituitary dysfunction induced by immune checkpoint inhibitors is associated with better overall survival in both malignant melanoma and non-small cell lung carcinoma: a prospective study.

J Immunother Cancer 2020 Jul;8(2)

Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, Nagoya, Japan

Background: Several immune-related adverse events (irAEs) are reported to be associated with therapeutic efficacy of immune checkpoint inhibitors, yet whether pituitary dysfunction, a life-threatening irAE, affects overall survival (OS) in patients with malignancies is unclear. This prospective study examined the association of pituitary dysfunction (pituitary-irAE) with OS of patients with non-small cell lung carcinoma (NSCLC) or malignant melanoma (MM).

Methods: A total of 174 patients (NSCLC, 108; MM, 66) treated with ipilimumab, nivolumab, pembrolizumab, or atezolizumab at Nagoya University Hospital were evaluated for OS and the development of pituitary-irAE. Read More

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http://dx.doi.org/10.1136/jitc-2020-000779DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7328763PMC

Pituitary Disease in Mutation-Positive Familial Isolated Pituitary Adenoma (FIPA): A Kindred-Based Overview.

J Clin Med 2020 Jun 26;9(6). Epub 2020 Jun 26.

Department of Endocrinology, Centre Hospitalaire Universitaire de Liège, Liège Université, 4000 Liège, Belgium.

Clinically-relevant pituitary adenomas occur in about 1:1000 of the general population, but only about 5% occur in a known genetic or familial setting. Familial isolated pituitary adenomas (FIPA) are one of the most important inherited settings for pituitary adenomas and the most frequent genetic cause is a germline mutation in the () gene. mutations lead to young-onset macroadenomas that are difficult to treat. Read More

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http://dx.doi.org/10.3390/jcm9062003DOI Listing

Stereotactic Radiosurgery for Residual and Recurrent Nonfunctioning Pituitary Adenomas: A Contemporary Case Series of GammaKnife and CyberKnife Radiosurgery.

World Neurosurg 2020 Jun 27. Epub 2020 Jun 27.

Department of Neurosurgery, Keck School of Medicine of the University of Southern California, Los Angeles, California. Electronic address:

Background: In patients with residual or recurrent non-functioning pituitary adenomas (NFPAs) following transsphenoidal resection, both GammaKnife (GKRS) and CyberKnife (CKRS) stereotactic radiosurgery (SRS) are viable treatment options.

Objectives: We report a retrospective single center series comparing assessing the effectiveness and complications from of these two commonly used SRS techniques.

Methods: 53 patients with prior surgical resection and residual or recurrent NFPAs who underwent GKRS or CKRS and minimum 3 months follow-up between January 2002 and February 2017 at a single center were identified. Read More

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http://dx.doi.org/10.1016/j.wneu.2020.06.191DOI Listing

The Presentation and Diagnosis of the First Known Community-Transmitted Case of SARS-CoV-2 in the Republic of Ireland.

Ir Med J 2020 May 7;113(5):78. Epub 2020 May 7.

Cork University Hospital, Wilton, Cork, Ireland.

Introduction This case series describes the diagnosis of the first case of community transmission of SARS-CoV-2 in the Republic of Ireland. Cases Case 1: A 25 year old male presented with dyspnoea, cough and high fevers for 4 days. He was commenced on broad-spectrum antimicrobials and oxygen therapy. Read More

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Efficacy of cabergoline and triptans for cluster-like headache caused by prolactin-secreting pituitary adenoma: A literature review and case report.

Clin Neurol Neurosurg 2020 Jun 13;196:106005. Epub 2020 Jun 13.

Department of Neurosurgery, Nishichita General Hospital, 3-1-1 Nakanoike, Tokai, Aichi, 477-8522, Japan. Electronic address:

Objective: Cluster-like headache (CLH) associated with pituitary adenoma (PA) is rare. Although numerous cases have been reported, no summary of the literature has been published. Furthermore, the mechanism and efficacy of medication in CLH associated with PA remains unknown. Read More

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http://dx.doi.org/10.1016/j.clineuro.2020.106005DOI Listing

Pediatric sinonasal and skull base lesions.

World J Otorhinolaryngol Head Neck Surg 2020 Jun 8;6(2):118-124. Epub 2020 Apr 8.

Department of Otolaryngology, Head and Neck Surgery, New York Presbyterian Hospital - Columbia University Medical Center, New York, NY, USA.

Pediatric skull base lesions are complex and challenging disorders. Safe and comprehensive management of this diverse group of disorders requires the expertise of an experienced multidisciplinary skull base team. Adult endoscopic skull base surgery has evolved due to technologic and surgical advancements, multidisciplinary team approaches, and continued innovation. Read More

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http://dx.doi.org/10.1016/j.wjorl.2020.01.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296510PMC

Effect of endoscopic endonasal skull base surgery on snoring.

Laryngoscope Investig Otolaryngol 2020 Jun 26;5(3):344-347. Epub 2020 Feb 26.

Department of Otolaryngology-Head and Neck Surgery Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea Seoul South Korea.

Background: As the number of endoscopic skull base surgeries has increased, postoperative changes in quality of life require attention, including evaluation of whether snoring symptoms change.

Objective: To investigate the effect of endoscopic endonasal skull base surgery on snoring and nasal symptom scores.

Methods: Between February 2009 and September 2018, 510 patients underwent skull base tumor resection via an endoscopic endonasal approach and were included in this study. Read More

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http://dx.doi.org/10.1002/lio2.335DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314477PMC

Preoperative vascular heterogeneity and aggressiveness assessment of pituitary macroadenoma based on dynamic contrast-enhanced MRI texture analysis.

Eur J Radiol 2020 Aug 13;129:109125. Epub 2020 Jun 13.

Department of Radiology, First Affiliated Hospital of Dalian Medical University, 222 Zhongshan Road, Xigang, Dalian, 116000, China. Electronic address:

Purpose: To assess the vascular heterogeneity and aggressiveness of pituitary macroadenomas (PM) using texture analysis based on Dynamic Contrast-Enhanced MRI (DCE-MRI).

Method: Fifty patients with pathologically confirmed PM, including 32 patients with aggressive PM (aggressive group) and 18 patients with non-aggressive PM (non-aggressive group), were included in this study. The preoperative DCE-MRI and clinical data were collected from all patients. Read More

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http://dx.doi.org/10.1016/j.ejrad.2020.109125DOI Listing

Cushing's Syndrome Caused By Ectopic ACTH-secreting Pituitary Adenomas: Case Report and Literature Review.

World Neurosurg 2020 Jun 24. Epub 2020 Jun 24.

Department of Neurosurgery, Chinese Academy of Medical Sciences and Peking Union Medical College, Peking Union Medical College Hospital, Beijing, China.

Background: Ectopic adrenocorticotropic hormone (ACTH)-secreting pituitary adenomas (EAPAs) are rare adenomas causing Cushing's syndrome (CS), which located in ectopic locations outside the sella turcica. Only no more than 100 cases of this entity have been reported before. Due to its rarity and nonspecific clinical and biochemical features, EAPA is often misdiagnosed, leading to surgical failure and delayed treatment. Read More

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http://dx.doi.org/10.1016/j.wneu.2020.06.138DOI Listing

TBR-760, a Dopamine-Somatostatin Compound, Arrests Growth of Aggressive Non-Functioning Pituitary Adenomas in Mice.

Endocrinology 2020 Jun 27. Epub 2020 Jun 27.

Scientific Advisory Board, Tiburio Therapeutics, Cambridge, MA.

TBR-760 (formerly BIM-23A760) is a chimeric dopamine (DA)-somatostatin (SST) compound with potent agonist activity at both DA type 2 (D2R) and SST type 2 (SSTR2) receptors. Studies have shown that chimeric DA-SST compounds are more efficacious than individual DA and/or SST analogs, either alone or combined, in inhibiting secretion from primary cultures of human somatotroph and lactotroph tumor cells. Non-functioning pituitary adenomas (NFPAs) express both D2R and SSTR2 and, consequently, may respond to TBR-760. Read More

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http://dx.doi.org/10.1210/endocr/bqaa101DOI Listing

Preclinical drug studies in MEN1-related neuroendocrine neoplasms (MEN1-NENs).

Endocr Relat Cancer 2020 Jun 1. Epub 2020 Jun 1.

R Thakker, Radcliffe Department of Medicine, University of Oxford, Endocrine Unit, OXFORD, United Kingdom of Great Britain and Northern Ireland.

Neuroendocrine neoplasms (NENs) occur usually as sporadic tumours; however, rarely, they may arise in the context of a hereditary syndrome, such as multiple endocrine neoplasia type 1 (MEN1), an autosomal dominant disorder characterised by the combined development of pancreatic NENs (pNENs) together with parathyroid and anterior pituitary tumours. The therapeutic decision for sporadic pNENs patients is multi-disciplinary and complex: based on the grade and stage of the tumor, various options (and their combinations) are considered, such as surgical excision (either curative or for debulking aims), biological drugs (somatostatin analogues), targeted therapies (mTOR inhibitors or tyrosine kinases (TK)/receptors inhibitors), peptide receptor radioligand therapy (PRRT), chemotherapy, and liver-directed therapies. However, treatment of MEN1-related NENs' patients is even more challenging, as these tumours are usually multifocal with co-existing foci of heterogeneous biology and malignant potential, rendering them more resistant to the conventional therapies used in their sporadic counterparts, and therefore associated with a poorer prognosis. Read More

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http://dx.doi.org/10.1530/ERC-20-0127DOI Listing

Pituitary adenoma presenting as acute onset isolated complete third cranial nerve palsy without vision changes.

BMJ Case Rep 2020 Jun 24;13(6). Epub 2020 Jun 24.

Child Sight Institute, Pediatric Ophthalmology, Strabismus and Neuro-ophthalmology, Nimmagadda Prasad Children Eye Care Centre, LV Prasad Eye Institute, GMRV Campus, Visakhapatnam, Andhra Pradesh, India

We report a case of isolated unilateral complete pupil involving third cranial nerve palsy due to pituitary adenoma with parasellar extension into the right cavernous sinus. The patient was referred to us from neurosurgery with sudden onset binocular vertical diplopia with complete ptosis, and mild right-sided headache of 5-day duration. Ocular examination revealed pupil involving third cranial nerve palsy in right eye while rest of the examination including automated perimetry was normal. Read More

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http://dx.doi.org/10.1136/bcr-2019-232490DOI Listing

Efficacy and safety of dopamine agonists in patients treated with antipsychotics and presenting a macroprolactinoma.

Eur J Endocrinol 2020 Aug;183(2):221-231

Assistance Publique Hôpitaux de Paris, Service d'Endocrinologie et des Maladies de la Reproduction, Centre de Référence des Maladies Rares de l'Hypophyse HYPO, Hôpital Bicêtre, Le Kremlin-Bicêtre, France.

Context: In patients treated with antipsychotics, the rare occurrence of a macroprolactinoma represents a therapeutic challenge.

Objective: Our aim was to evaluate the efficacy and psychiatric safety of dopamine agonists (DAs) prescribed for large macroprolactinomas in patients with psychosis treated with antipsychotics.

Design: This was a multicenter (France and Belgium) retrospective study. Read More

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http://dx.doi.org/10.1530/EJE-20-0125DOI Listing

Diabetes insipidus and syndrome of inappropriate antidiuresis (SIADH) after pituitary surgery: incidence and risk factors.

Neurosurg Rev 2020 Jun 24. Epub 2020 Jun 24.

Department of Neurosurgery, Clinical Neuroscience Center, University Hospital Zurich, University of Zurich, Zurich, Switzerland.

Electrolyte disorders are relatively frequent and potentially serious complications after pituitary surgery. Both DI (diabetes insipidus) and SIADH (syndrome of inappropriate antidiuresis) can complicate and prolong hospital and intensive care unit stay, and the latter may even be preventable. We aim to assess the incidence of both electrolyte disorders and their risk factors. Read More

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http://dx.doi.org/10.1007/s10143-020-01340-0DOI Listing

Identification of a multidimensional transcriptome signature predicting tumor regrowth of clinically non‑functioning pituitary adenoma.

Int J Oncol 2020 Jun 23. Epub 2020 Jun 23.

Beijing Neurosurgical Institute, Beijing Tiantan Hospital Affiliated to Capital Medical University, Beijing Institute for Brain Disorders Brain Tumor Center, China National Clinical Research Center for Neurological Diseases, Key Laboratory of Central Nervous System Injury Research, Beijing 100070, P.R. China.

Clinically non‑functioning pituitary adenoma (NFPA) represents approximately one third of all pituitary adenomas. Tumor regrowth is an important feature of NFPA; however, the effective methods with which to predict this are limited. The present study analyzed the expression of protein‑coding genes and long non‑coding RNA in 66 patients with NFPA. Read More

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http://dx.doi.org/10.3892/ijo.2020.5087DOI Listing

Comparing Stereotactic Radiosurgery and Fractionated Stereotactic Radiotherapy in Treating patients with Growth Hormone-Secreting Adenomas: A Systematic Review and Meta-analysis.

Endocr Pract 2020 Jun 23. Epub 2020 Jun 23.

From: Department of Endocrinology, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou, 350001, China.

Radiotherapy for patients with acromegaly was considered when patients have residual disease or tumor recurrence after surgery, or when surgery can't be carried out. There are two main modes of radiotherapy, including stereotactic radiosurgery (SRS) and fractionated stereotactic radiotherapy (FSRT). We conducted a systematic review and meta-analysis to present the effectiveness and safety of SRS and FSRT for GH secreting pituitary adenoma in clinical practice. Read More

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http://dx.doi.org/10.4158/EP-2020-0110DOI Listing