41,593 results match your criteria Pituitary Adenoma


Ectopic TSH-secreting Pituitary Adenoma in Nasopharyngeal Region.

Acta Endocrinol (Buchar) 2021 Oct-Dec;17(4):521-527

Department of Radiology, Department of Endocrinology and Metabolism, Meram, Konya, "Pamukkale" University, Faculty of Medicine, Denizli, Turkey.

Objective: TSH-secreting pituitary adenomas (TSH-omas) are very rare disorders. This report describes the diagnosis and treatment of a thyroid-stimulating hormone-secreting ectopic pituitary adenoma in the nasopharyngeal region.

Subjects And Methods: We report a 37-year-old male patient with thyroid-stimulating hormone-secreting ectopic pituitary adenoma in nasopharyngeal region. Read More

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Xanthogranuloma of the Sellar Region: A Comprehensive Review of Neuroimaging in a Rare Inflammatory Entity.

J Pers Med 2022 Jun 8;12(6). Epub 2022 Jun 8.

Department of Endocrinology, "Iuliu Hatieganu" University of Medicine and Pharmacy Cluj-Napoca, 8 Victor Babes Street, 400012 Cluj-Napoca, Romania.

Xanthogranuloma of the sellar region is a rare chronic inflammatory lesion resulting from secondary hemorrhage, inflammation, infarction, and necrosis of an existing Rathke's cleft cyst, craniopharyngioma, or pituitary adenoma. Sellar xanthogranulomas are challenging to differentiate from other cystic lesions preoperatively due to the lack of characteristic imaging features. We performed a literature overview of the clinical and paraclinical features, treatment options, and long-term outcomes of patients with sellar xanthogranuloma, focusing on the preoperative radiological diagnosis. Read More

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Hypogonadism in Male Patients with Pituitary Adenoma and Its Related Mechanism: A Review of Literature.

Brain Sci 2022 Jun 17;12(6). Epub 2022 Jun 17.

Department of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.

Maintaining normal gonadal axis hormone levels is important for improving the condition of male patients with pituitary adenoma. The current literature is somewhat divided on the results of evaluations of gonadal axis function in male patients with pituitary adenoma before and after treatment, and the increasing demand for better quality of life has provided motivation for this research to continue. In this article, we summarize the feasibility of using testosterone as an indicator for assessing male function and discuss the changes reported in various studies for gonadal hormones before and after treatment in male patients with pituitary adenoma. Read More

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Efficacy of different minimally invasive surgical methods for transsphenoidal resection of pituitary adenoma: A systematic review and meta-analysis.

Asian J Surg 2022 Jun 21. Epub 2022 Jun 21.

Department of Third Surgical, The Central Hospital of Enshi Tujia and Miao Autonomous Prefecture, Enshi 445000, China. Electronic address:

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Endoscopic endonasal approach for simultaneously treating a pituitary adenoma coexisting with a paraclinoid aneurysm: illustrative case.

J Neurosurg Case Lessons 2022 Jun 20;3(25):CASE22130. Epub 2022 Jun 20.

Department of Neurosurgery, Yongzhou Central Hospital, Yongzhou City, Hunan Province, People's Republic of China.

Background: There is a certain incidence of pituitary adenomas coexisting with intracranial aneurysms, but a concurrent therapeutic strategy of tumor removal and aneurysm clipping via endoscopic endonasal approach is rarely reported. The indications and limitations of endoscopic endonasal approach surgery for this type of lesions are worth discussing.

Observations: The case of a pituitary tumor coexisting with a paraclinoid aneurysm was reviewed. Read More

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Subclinical acromegaly: to treat or not to treat?

Endocr J 2022 Jun 22. Epub 2022 Jun 22.

Institute of Endocrinology, Beilinson Hospital, Petach Tikva 4941492, Israel.

Patients with acromegaly usually present with the classical signs of acromegaly, whereas patients without the specific signs or symptoms are rarely diagnosed. This unique entity can be named "subclinical acromegaly". This was a retrospective study. Read More

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SIRT1 suppresses pituitary tumor progression by downregulating PTTG1 expression.

Oncol Rep 2022 Aug 22;48(2). Epub 2022 Jun 22.

Department of Neurosurgery, Shanghai Institute of Neurosurgery, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai 200003, P.R. China.

Although pituitary tumors are among the most common types of brain tumor, the underlying molecular mechanism of this disease remains obscure. To this end, the role of sirtuin 1 (SIRT1) in pituitary tumors was reported. The results of reverse transcription‑quantitative PCR and immunohistochemistry revealed that sirtuin 1 (SIRT1) expression was downregulated in the tumor tissues of patients with pituitary tumors. Read More

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An altered state of consciousness while using anticoagulants and the incidental discovery of a pituitary lesion: considering pituitary apoplexy.

Endocrinol Diabetes Metab Case Rep 2022 Jun 1;2022. Epub 2022 Jun 1.

Endocrinology Unit, Department of Clinical and Experimental Medicine.

Summary: Pituitary apoplexy (PA) is a medical emergency with complex diagnosis and management. In this study, we describe a case of PA in a 63-year-old male treated with oral anticoagulant therapy for atrial fibrillation. In the patient, PA manifested itself with asthenia and severe headache not responsive to common analgesics. Read More

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Endoscopic Transpterygoid Transcavernous Approach for Resection of a Petroclival Chondrosarcoma: 2-Dimensional Operative Video.

Oper Neurosurg (Hagerstown) 2022 Jul 20;23(1):e60-e61. Epub 2022 Apr 20.

Department of Neurosurgery, Neurological Institute, Cleveland Clinic, Cleveland, Ohio, USA.

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Comparative efficacy and safety of therapeutics for elderly glioblastoma patients: A Bayesian network analysis.

Pharmacol Res 2022 Jun 17;182:106316. Epub 2022 Jun 17.

Departments of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, PR China; State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, PR China; China Pituitary Disease Registry Center, Chinese Pituitary Adenoma Cooperative Group, Beijing, PR China; China Alliance of Rare Diseases, Beijing, PR China. Electronic address:

Optimal management strategies for elderly glioblastoma (GBM) patients remain elusive. Overall survival (OS) and progression-free survival (PFS) in elderly newly diagnosed GBM (ndGBM) patients were analyzed with random-effects Bayesian network meta-analysis with the estimated hazard ratio (HR) with a 95% confidence interval (95% CrI). In addition, OS, PFS and adverse event (AE) data on ndGBM and recurrent GBM (rGBM) were assessed. Read More

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Case Report: Acquired Generalized Anhidrosis Caused by Brain Tumor: Review of the Literature.

Front Endocrinol (Lausanne) 2022 26;13:877715. Epub 2022 May 26.

Department of Pediatrics, Aichi Medical University School of Medicine, Nagakute, Japan.

Purpose: There has been limited focus on sweating failure in patients with brain tumor. We report two patients with generalized anhidrosis caused by germinoma. We also review previous reports of generalized anhidrosis due to brain tumor. Read More

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DRD2 Agonist Cabergoline Abolished the Escape Mechanism Induced by mTOR Inhibitor Everolimus in Tumoral Pituitary Cells.

Front Endocrinol (Lausanne) 2022 3;13:867822. Epub 2022 Jun 3.

Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy.

The mammalian target of rapamycin (mTOR) inhibitor everolimus has been shown to display antiproliferative effects on a wide spectrum of tumors. studies demonstrated that everolimus inhibited pituitary neuroendocrine tumor (PitNET) cell growth in a subset of patients. Sensitivity to everolimus is reduced by an escape mechanism that increases AKT phosphorylation (p-AKT), leading to pro-survival pathway activation. Read More

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Coping strategies in patients undergoing surgery treatment for pituitary tumour in China: A cross-sectional survey.

Nurs Open 2022 Jun 19. Epub 2022 Jun 19.

Department of Neurosurgery, First Affiliated Hospital of Soochow University, Suzhou, China.

Aim: To explore the coping strategies and corresponding influence factors in patients undergone surgeries for pituitary tumours.

Design: A cross-sectional study.

Methods: Patients diagnosed with pituitary tumours were included. Read More

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The evaluation of changes in maxillofacial bones using cone beam tomography in acromegaly.

Med Oral Patol Oral Cir Bucal 2022 Jul 1;27(4):e357-e365. Epub 2022 Jul 1.

Erciyes University , Faculty of Dentistry Department of Oral and Maxillofacial Surgery 38039 Kayseri, Turkey

Background: The aim of the study was to evaluate the changes in craniofacial dimensions of newly diagnosed and untreated acromegaly patients, patients with non-functional pituitary adenoma and healthy individuals on Cone Beam Computed Tomography (CBCT).

Material And Methods: 50 newly diagnosed acromegaly patients who did not receive any treatment for acromegaly were included in the study (Group A). Twenty patients with nonfunctional pituitary adenoma (Group B) and 30 healthy individuals were included (Group C). Read More

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Recurrent Metatarsal Fractures in a Patient With Cushing Disease: A Case Report.

Cureus 2022 May 15;14(5):e25015. Epub 2022 May 15.

Department of Orthopaedic Surgery, Mayo Clinic, Jacksonville, USA.

Cushing syndrome (CS) can result from excess exposure to exogenous or endogenous glucocorticoids. The most common endogenous cause of CS is an adrenocorticotropic hormone (ACTH)-secreting pituitary adenoma, known as Cushing disease (CD). Patients typically present with characteristics including truncal obesity, moon facies, facial plethora, proximal muscle weakness, easy bruising, and striae. Read More

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Microscopic Transsphenoidal Resection of Giant Pituitary Adenomas: Analysis of the Factors Limiting the Degree of Resection in 73 Cases.

Front Neurol 2022 27;13:880732. Epub 2022 May 27.

Department of Neurosurgery, The 900th Hospital, Fuzong Clinical Medical College of Fujian Medical University, Fuzhou, China.

Purpose: To analyze the risk factors affecting the gross-total resection of giant pituitary adenomas using a transsphenoidal approach under a microscope to provide a reference basis for formulating an appropriate surgical strategy.

Methods: The clinical data of patients who underwent microscopic transsphenoidal resection of giant pituitary adenomas in a single center from January 2011 to December 2020 were retrospectively analyzed. Based on magnetic resonance imaging and surgical records, the predictive factors affecting the gross-total resection of giant pituitary adenomas under microscopy were determined through univariate and multivariate analyses. Read More

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A systematic review of molecular alterations in invasive non-functioning pituitary adenoma.

Endocrine 2022 Jun 16. Epub 2022 Jun 16.

Endocrine Research Center, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences, Tehran, Iran.

Purpose: Invasive non-functional pituitary adenomas (NFPAs) constitute 35% of NFPAs. Despite a relatively large body of molecular investigations on the invasiveness of NFPA, the underlying molecular mechanisms of invasiveness are yet to be determined. Herein, we aimed to provide an overview of gene/microRNA(miRNAs) expression alterations in invasive NFPA. Read More

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Pathological and Prognostic Characterization of Craniopharyngioma Based on the Expression of TrkA, β-Catenin, Cell Cycle Markers, and BRAF V600E Mutation.

Front Endocrinol (Lausanne) 2022 30;13:859381. Epub 2022 May 30.

Department of Pathology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.

We collected 61 craniopharyngioma (CP) specimens to investigate the expression of TrkA, β-catenin, BRAF gene mutation, and NTRK1 fusion in CP. There were 37 male and 24 female individuals with a median age of 34 years (range, 4-75 years). Histologically, there were 46 cases of adamantinomatous craniopharyngioma (ACP), 14 cases of papillary craniopharyngioma (PCP), and 1 case with a mixed adamantinomatous and papillary pattern. Read More

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Prospective intraoperative and histologic evaluation of cavernous sinus medial wall invasion by pituitary adenomas and its implications for acromegaly remission outcomes.

Sci Rep 2022 Jun 15;12(1):9919. Epub 2022 Jun 15.

Department of Neurosurgery, Stanford University Medical Center, Stanford, California, USA.

Recurrence and biochemical remission rates vary widely among different histological subtypes of pituitary adenoma. In this prospective study, we evaluated 107 consecutive primary pituitary adenomas operated on by a single neurosurgeon including 28 corticotroph, 27 gonadotroph, 24 somatotroph, 17 lactotroph, 5 null-cell and 6 plurihormonal. In each case, we performed direct endoscopic intraoperative inspection of the medial wall of the cavernous sinus, which was surgically removed when invasion was visualized. Read More

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A Case of Pituitary Macroadenoma Presenting as Aseptic Meningitis.

S D Med 2022 Feb;75(2):88-90

University of South Dakota Sanford School of Medicine, Sioux Falls, South Dakota.

Pituitary adenomas are a common brain tumor that are frequently asymptomatic but may initially present with vision deficits or very rarely as meningitis thought to be due to cerebrospinal fluid leakage. In this case report we discuss the initial presentation of a pituitary macroadenoma as aseptic meningitis, particularly in the absence of an identifiable cerebrospinal fluid leak. We also discuss the workup and diagnostic challenges associated with this atypical presentation, including findings on imaging and pertinent laboratory results. Read More

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February 2022

Recent advancements in the molecular biology of pituitary adenomas.

Expert Rev Endocrinol Metab 2022 Jun 14:1-12. Epub 2022 Jun 14.

Department of Neurosurgery; University of California at San Francisco (UCSF) San Francisco, CA, USA.

Introduction: Pituitary adenomas are a common and diverse group of intracranial tumors arising from the anterior pituitary that are usually slow-growing and benign, but still pose a significant healthcare burden to patients. Additionally, they are increasing in both incidence and prevalence, leading to a need for better understanding of molecular changes in the development of these tumors.

Areas Covered: A PubMed literature search was conducted using the terms 'pituitary adenoma' in combination with keywords related to secretory subtype: lactotroph, somatotroph, corticotroph, gonadotroph and null cell, in addition to their transcription factor expression: PIT1, TPIT, and SF-1. Read More

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Natural history of pituitary apoplexy: a long-term follow-up study.

Postgrad Med J 2022 Jun 14. Epub 2022 Jun 14.

Endocrine and Diabetes, Morriston Hospital, Swansea, UK.

Background And Aims: Pituitary apoplexy (PA) is a rare neurosurgical emergency, associated with deficiency of one or more pituitary hormones. Few studies have explored the relative outcomes associated with conservative and neurosurgical intervention.

Methods: A retrospective evaluation of all patients with PA reviewed at Morriston Hospital was undertaken and diagnosis was obtained from Morriston database (Leicester Clinical Workstation database) between 1998 and 2019 from clinic letters and discharge summaries. Read More

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Analysis of 55 patients with multiple endocrine neoplasia type 1-associated insulinoma from a single center in China.

Orphanet J Rare Dis 2022 06 13;17(1):219. Epub 2022 Jun 13.

Department of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, 100730, China.

Objective: To investigate the clinical characteristics of patients with multiple endocrine neoplasia type 1 (MEN1)-related insulinoma and their relationship with specific biochemical changes and to summarize the features of treatment options for the Chinese population with this disease and the impact on long-term prognosis.

Methods: "MEN1" and "insulinoma" were used when searching the Peking Union Medical College Hospital (PUMCH) medical record retrieval system to obtain clinical information about patients. We identified patients diagnosed with MEN1-associated insulinoma based on endocrinological, radiological, and pathological examinations, and subsequently analyzed their clinical data. Read More

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Epidemiology of Cancer Among Chronic Kidney Disease Patients Compared to The General Population.

Gulf J Oncolog 2022 May;1(39):7-15

The Medicine Department, MOHAP, Dubai, UAE.

Background: Kidney disease has a major effect on global health, both as direct cause of morbidity and mortality and as an important factor for other comorbid diseases including malignancy. Different studies report a higher risk of cancer development in patients with chronic kidney disease (CKD), but the impact of less sever CKD on risk of cancer is uncertain. However, data concerning the cancer risk in Oman CKD including dialysis patients is scarce. Read More

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Surgical Strategies and Outcomes for Intracranial Chondromas: A Retrospective Study of 17 Cases and Systematic Review.

Front Oncol 2022 26;12:865865. Epub 2022 May 26.

Department of Neurosurgery, Tangdu Hospital, Air Force Medical University, Xi'an, China.

Objective: To improve the diagnosis and treatment of intracranial chondromas (ICDs) by discussing the clinical manifestations and imaging characteristics of ICDs, as well as surgical methods and treatment strategies.

Methods: We retrospectively analyzed 17 patients diagnosed with ICDs who underwent microsurgery or endoscopic transsphenoidal surgery at the Tangdu Hospital of Air Force Military Medical University and the Mianyang Central Hospital from January 2010 to November 2021. Clinical manifestations, imaging examinations, surgical treatments, and prognosis of these patients were analyzed. Read More

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Hypothalamic connectivities predict individual differences in ADT-elicited changes in working memory and quality of life in prostate cancer patients.

Sci Rep 2022 Jun 10;12(1):9567. Epub 2022 Jun 10.

Cancer Center, VA Connecticut Healthcare System, 950 Campbell Avenue, West Haven, CT, 06516, USA.

Androgen deprivation therapy (ADT) has been associated with adverse effects on cognition. However, we currently lack understanding of the neurobiology and prognostic markers of these effects. Given that ADT acts via the hypothalamus-pituitary-gonadal axis, we assessed whether baseline hypothalamic resting state functional connectivity (rsFC) could predict changes in working memory and quality of life in prostate cancer patients following androgen deprivation. Read More

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Pretreating cavernous sinus with hemostatic agent injection molding during endoscopic endonasal pituitary surgery: technical note.

Acta Neurochir (Wien) 2022 Jun 10. Epub 2022 Jun 10.

Department of Neurosurgery, Tangdu Hospital, Air Force Medical University, Xi'an, Shaanxi, China.

Objective: To clarify the technical pearls of cavernous sinus molding technique with hemostatic agent injection during endoscopic endonasal pituitary surgery.

Methods: All patients pretreated with cavernous sinus hemostatic agent injection molding technique for hemostasis in endoscopic endonasal surgery for pituitary adenoma resection between November 2017 and June 2021 were included. A small incision was made in the cavernous sinus wall before intracavernous manipulation. Read More

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Infra-Temporal and Pterygo-Palatine Fossae Tumors: A Frontier in Endoscopic Endonasal Surgery-Description of the Surgical Anatomy of the Approach and Report of Illustrative Cases.

Int J Environ Res Public Health 2022 May 25;19(11). Epub 2022 May 25.

Programma Neurochirurgia Ipofisi-Pituitary Unit, IRCCS Istituto delle Scienze Neurologiche di Bologna, 40139 Bologna, Italy.

Infratemporal and pterygopalatine fossae (ITF and PPF) represent two complex paramedian skull base areas, which can be defined as jewelry boxes, containing a large number of neurovascular and osteomuscular structures of primary importance. They are in close communication with many craniofacial areas, such as nasal/paranasal sinuses, orbit, middle cranial fossa, and oral cavities. Therefore, they can be involved by tumoral, infective or inflammatory lesions spreading from these spaces. Read More

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Machine Learning for the Detection and Segmentation of Benign Tumors of the Central Nervous System: A Systematic Review.

Cancers (Basel) 2022 May 27;14(11). Epub 2022 May 27.

Department of Radiation Oncology, Kantonsspital Aarau, 5001 Aarau, Switzerland.

: To summarize the available literature on using machine learning (ML) for the detection and segmentation of benign tumors of the central nervous system (CNS) and to assess the adherence of published ML/diagnostic accuracy studies to best practice. : The MEDLINE database was searched for the use of ML in patients with any benign tumor of the CNS, and the records were screened according to PRISMA guidelines. : Eleven retrospective studies focusing on meningioma (n = 4), vestibular schwannoma (n = 4), pituitary adenoma (n = 2) and spinal schwannoma (n = 1) were included. Read More

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Primary Hypothyroidism with Pituitary Hyperplasia in an Omani Girl.

Case Rep Endocrinol 2022 29;2022:3382612. Epub 2022 May 29.

Department of Pediatric Endocrinology, National Diabetes and Endocrine Center, Royal Hospital, Muscat, Oman.

Pituitary hyperplasia secondary to primary hypothyroidism (PHPH) is uncommon in children and is reversible with thyroxine therapy. We report an Omani girl who presented at the age of 13 years and 6 months with profound primary hypothyroidism due to Hashimoto's thyroiditis and secondary pituitary hyperplasia and hyperprolactinemia. Pituitary magnetic resonance imaging confirmed the presence of pituitary hyperplasia which regressed during follow-up after the administration of thyroxine therapy. Read More

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