37,300 results match your criteria Pituitary Adenoma


TSP-1 is downregulated and inversely correlates with miR-449c expression in Cushing's disease.

J Cell Mol Med 2019 Apr 23. Epub 2019 Apr 23.

Department of Neurosurgery, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, P.R. China.

The pathogenesis of Cushing's disease, which is caused by pituitary corticotroph adenoma, remains to be studied. Secreted angioinhibitory factor thrombospondin-1 (TSP-1) is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions and is associated with platelet aggregation, angiogenesis and tumorigenesis. We have found that the expression of TSP-1 is significantly lower in human pituitary corticotroph tumours compared with normal adenohypophysis. Read More

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http://dx.doi.org/10.1111/jcmm.14297DOI Listing

Prolactin-adjusted ACTH Ratio in Predicting Lateralization of ACTH Source During Simultaneous Bilateral Inferior Petrosal Sinus Sampling in Patients with Cushing's Disease.

Indian J Endocrinol Metab 2019 Jan-Feb;23(1):56-59

Department of Endocrinology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Introduction: Prolactin-adjusted adrenocorticotropic hormone (ACTH) ratio is used to improve the diagnostic accuracy of bilateral inferior petrosal sinus sampling (BIPSS) for lateralization of pituitary adenoma.

Objective: To study the use of prolactin for successful catheterization during BIPSS, the role of prolactin-normalized ACTH ratio for confirmation of Cushing's disease (CD) and prolactin-adjusted ACTH ratio in predicting the lateralization.

Patients And Methods: BIPSS was done in patients with CD; prolactin-adjusted ACTH ratio was compared with intersinus ACTH ratio, magnetic resonance imaging, and intraoperative findings for localization of pituitary adenoma. Read More

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http://dx.doi.org/10.4103/ijem.IJEM_486_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446680PMC
April 2019
1 Read

Sudden Headache and Blindness Due to Pituitary (Adenoma) Infarction: A Case Report.

Cureus 2019 Feb 13;11(2):e4059. Epub 2019 Feb 13.

Neurosurgery, Seattle Science Foundation, Seattle, USA.

Pituitary infarction (PI) is a rare medical emergency appearing in patients with pituitary adenoma, presenting with sudden onset of severe headache, and often associated with vomiting, nausea, visual deterioration, and decreased consciousness. We describe an 83-year-old woman who presented with blindness after a history of severe headache. An urgent computed tomography (CT) scan of the brain had been arranged, and a massive pituitary adenoma with hemorrhage was observed, and admission to the neurosurgical department followed. Read More

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https://www.cureus.com/articles/17754-sudden-headache-and-bl
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http://dx.doi.org/10.7759/cureus.4059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6464289PMC
February 2019
1 Read

Associations of cholesteryl ester transfer protein (CETP) gene variants with pituitary adenoma.

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2019 Apr 17. Epub 2019 Apr 17.

Neuroscience Institute, Lithuanian University of Health Sciences, Medical Academy, Eiveniu 2, Kaunas, Lithuania.

Aim: The aim was to evaluate the association of CETP (rs5882 and rs708272) single nucleotide polymorphisms with the presence, invasiveness, hormonal activity and recurrence of pituitary adenoma (PA).

Methods: The study group included 142 patients with PA and the control group, 753 healthy subjects. The genotyping of CETP (rs5882 and rs708272) was performed using a real-time PCR method. Read More

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http://dx.doi.org/10.5507/bp.2019.016DOI Listing

Non-functioning pituitary adenomas: indications for pituitary surgery and post-surgical management.

Pituitary 2019 Apr 22. Epub 2019 Apr 22.

Department of Endocrinology, Institute of Medicine, Sahlgrenska University Hospital, Sahlgrenska Academy, University of Gothenburg, SE-413 45, Gothenburg, Sweden.

Purpose: Non-functioning pituitary adenomas (NFPAs) are associated with impaired well-being, increased comorbidities, and reduced long-term survival. Data on optimal management of NFPAs around surgical treatment are scarce, and postoperative treatment and follow-up strategies have not been evaluated in prospective trials. Here, we review the preoperative, perioperative, and early postoperative management of patients with NFPAs. Read More

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http://dx.doi.org/10.1007/s11102-019-00960-0DOI Listing

Preoperative evaluation of tumour consistency in pituitary macroadenomas: a machine learning-based histogram analysis on conventional T2-weighted MRI.

Neuroradiology 2019 Apr 22. Epub 2019 Apr 22.

Department of Radiology, Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa, Istanbul, Turkey.

Purpose: To evaluate the potential value of machine learning (ML)-based histogram analysis (or first-order texture analysis) on T2-weighted magnetic resonance imaging (MRI) for predicting consistency of pituitary macroadenomas (PMA) and to compare it with that of signal intensity ratio (SIR) evaluation.

Methods: Fifty-five patients with 13 hard and 42 soft PMAs were included in this retrospective study. Histogram features were extracted from coronal T2-weighted original, filtered and transformed MRI images by manual segmentation. Read More

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http://dx.doi.org/10.1007/s00234-019-02211-2DOI Listing

A case of functioning gonadotroph adenoma in a reproductive aged woman.

Endocr J 2019 Apr 19. Epub 2019 Apr 19.

Department of Obstetrics and Gynecology, The University of Tokyo Hospital, Tokyo 1138655, Japan.

A 34-year-old woman presented our hospital with complaint of irregular menstruation and abnormal uterine bleeding lasting for a month. After her second parturition at the age of 27, her menstrual cycle had been regular, but it suddenly became irregular at the age of 30. Transvaginal ultrasound revealed the presence of ovarian mass, and the patient underwent diagnostic laparoscopic surgery. Read More

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https://www.jstage.jst.go.jp/article/endocrj/advpub/0/advpub
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http://dx.doi.org/10.1507/endocrj.EJ19-0066DOI Listing
April 2019
1 Read

Clinical vasospasm after an extended endoscopic assisted approach for recurrent pituitary adenoma. Illustrative case and systematic review of the literature.

World Neurosurg 2019 Apr 16. Epub 2019 Apr 16.

Division of Neurosurgery, Department of Neurosciences, Reproductive and Odontostomatological Sciences, Università; degli Studi di Napoli "Federico II", Naples, Italy.

Introduction: Cerebral vasospasm causing delayed cerebral ischemia after transsphenoidal surgery is a rare but life-threatening complication. Reports in the literature regarding extended endonasal endoscopic assisted (EEEA) approaches are scarce. Considering the progressive use of this technique during the last years, a better understanding of potential adverse effects after this procedure is needed. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.04.046DOI Listing
April 2019
1 Read

Tuberculosis: A Common Infection with Rare Presentation, Isolated Sellar Tuberculoma with Panhypopituitarism.

J Neurosci Rural Pract 2019 Apr-Jun;10(2):327-330

Department of Neurosurgery, Superspeciality Hospital and Government Medical College, Nagpur, Maharashtra, India.

Isolated sellar tuberculoma is a very rare condition and usually presents with headache and decreased vision. It can present with panhypopituitarism with 3 nerve palsy. Tuberculoma mimics pituitary adenoma clinically as well as radiologically and requires endoscopic transsphenoidal surgery and histopathological examination for the final diagnosis. Read More

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http://www.ruralneuropractice.com/text.asp?2019/10/2/327/254
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http://dx.doi.org/10.4103/jnrp.jnrp_332_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454932PMC
April 2019
1 Read

Sellar region: magnetic resonance imaging assessment of uncommon tumors and pseudotumors.

Radiologia 2019 Apr 15. Epub 2019 Apr 15.

Servicio de Diagnóstico por Imágenes, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.

Objective: To show the usefulness of magnetic resonance imaging in the anatomic and pathologic characterization of the sellar region, emphasizing the differential diagnosis of uncommon non-adenomatous tumors and pseudotumors studied in our institution.

Conclusion: The sellar region is a complex anatomic space with diverse types of tissues from which a wide spectrum of diseases can arise. Magnetic resonance imaging's high tissue resolution and ability to characterize the patterns of tumor growth and biological behavior make it the best imaging technique to study this region. Read More

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http://dx.doi.org/10.1016/j.rx.2019.02.006DOI Listing

An Extended Endoscopic Endonasal Approach for Sellar Area Chondrosarcoma: A Case Report and Literature Review.

World Neurosurg 2019 Apr 14. Epub 2019 Apr 14.

Department of Neurosurgery, the First Affiliated Hospital of Fujian Medical University, Fuzhou, People's Republic of China.

Background: Chondrosarcoma is a malignant tumor that originates from mesenchymal cells that have differentiated into chondrocytes, often growing laterally, rarely seen in the cranium, and seldom seen in the saddle area. We believe that only a few cases have been reported in the literature. We report a case of pituitary fossa chondrosarcoma, which was completely resected by an extended endoscopic endonasal approach, and a literature review. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.04.075DOI Listing
April 2019
2 Reads

MANAGEMENT AND OUTCOMES OF GIANT PROLACTINOMA: A SERIES OF 71 PATIENTS.

Endocr Pract 2019 Apr;25(4):340-352

To describe outcomes of patients with giant prolactinoma (≥4 cm) and identify predictors of therapeutic response. In this retrospective study, complete biochemical and structural response were defined as prolactin (PRL) ≤25 ng/mL and no visible tumor at follow-up, respectively. Giant prolactinoma (median size, 4. Read More

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http://journals.aace.com/doi/10.4158/EP-2018-0392
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http://dx.doi.org/10.4158/EP-2018-0392DOI Listing
April 2019
2 Reads

Effect of lncRNA HULC knockdown on rat secreting pituitary adenoma GH3 cells.

Braz J Med Biol Res 2019 15;52(4):e7728. Epub 2019 Apr 15.

Department of Pain Clinic, The First Affiliated Hospital of Xiamen University, Fujian Medical University, Xiamen, Fujian, China.

Pituitary adenoma is one of the most common tumors in the neuroendocrine system. This study investigated the effects of long non-coding RNAs (lncRNAs) highly up-regulated in liver cancer (HULC) on rat secreting pituitary adenoma GH3 cell viability, migration, invasion, apoptosis, and hormone secretion, as well as the underlying potential mechanisms. Cell transfection and qRT-PCR were used to change and measure the expression levels of HULC, miR-130b, and FOXM1. Read More

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S
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http://dx.doi.org/10.1590/1414-431X20197728DOI Listing
April 2019
2 Reads

Temozolomide cytoreductive treatment in a giant cabergoline-resistant prolactin-secreting pituitary neuroendocrine tumor.

Anticancer Drugs 2019 Jun;30(5):533-536

Endocrinology Unit, Department of Medicine (DMID).

Dopamine agonists (DAs, especially cabergoline) are recommended as first-line treatment in patients with prolactin-secreting pituitary adenomas, to reduce hormone secretion and tumor size. Pituitary surgery, suggested in nonresponsive patients, cannot achieve a gross total resection or is not feasible in some cases. Temozolomide (TMZ) has been proposed in patients with aggressive pituitary neuroendocrine tumors (PitNETs) who do not respond to conventional treatments. Read More

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http://dx.doi.org/10.1097/CAD.0000000000000768DOI Listing
June 2019
1 Read

Benzene affects the response to octreotide treatment of growth hormone secreting pituitary adenoma cells.

Environ Res 2019 Apr 8;173:489-496. Epub 2019 Apr 8.

Division of Oncological Endocrinology, Città della Salute e della Scienza University Hospital, I-10126, Turin, Italy. Electronic address:

Growth hormone (GH) secreting pituitary adenomas are the main cause of acromegaly. Somatostatin analogs are the gold standard of medical therapy; however, resistance represents a big drawback in acromegaly management. We recently demonstrated that benzene (BZ) modifies the aggressiveness of GH-secreting rat pituitary adenoma cells (GH3), increasing GH secretion and altering the synthesis of molecules involved in the somatostatin signaling pathway. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00139351193021
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http://dx.doi.org/10.1016/j.envres.2019.04.007DOI Listing
April 2019
2 Reads

Identification of Important Invasion-Related Genes in Non-functional Pituitary Adenomas.

J Mol Neurosci 2019 Apr 13. Epub 2019 Apr 13.

Biostatistics and Bioinformatics, Chanabasava Nilaya, Bharthinagar, Dharwad, Karnataka, 580001, India.

Non-functioning pituitary adenomas (NFPAs) are locally invasive with high morbidity. The objective of this study was to diagnose important genes and pathways related to the invasiveness of NFPAs and gain more insights into the underlying molecular mechanisms of NFPAs. The gene expression profiles of GSE51618 were downloaded from the Gene Expression Omnibus database with 4 non-invasive NFPA samples, 3 invasive NFPA samples, and 3 normal pituitary gland samples. Read More

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http://link.springer.com/10.1007/s12031-019-01318-8
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http://dx.doi.org/10.1007/s12031-019-01318-8DOI Listing
April 2019
1 Read

Radiation dose to neuroanatomical structures of pituitary adenomas and the effect of Gamma Knife radiosurgery on pituitary function.

J Neurosurg 2019 Apr 12:1-8. Epub 2019 Apr 12.

Departments of1Neurosurgery.

OBJECTIVEGamma Knife radiosurgery (GKRS) provides a safe and effective management option for patients with all types of pituitary adenomas. The long-term adverse effects of targeted radiation to the hypothalamic-pituitary axis in relationship to radiation dose remain unclear. In this retrospective review, the authors investigated the role of differential radiation doses in predicting long-term clinical outcomes and pituitary function after GKRS for pituitary adenomas. Read More

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http://dx.doi.org/10.3171/2019.1.JNS182296DOI Listing

Unmasking a new prognostic marker and therapeutic target from the GDNF-RET/PIT1/p14ARF/p53 pathway in acromegaly.

EBioMedicine 2019 Apr 8. Epub 2019 Apr 8.

Neoplasia & Endocrine Differentiation P0L5, Centro de Investigación en Medicina Molecular y Enfermedades Crónicas (CIMUS), University of Santiago de Compostela (USC), Spain; Instituto de Investigación Sanitaria (IDIS), Santiago de Compostela, Spain. Electronic address:

Background: Acromegaly is produced by excess growth hormone secreted by a pituitary adenoma of somatotroph cells (ACRO). First-line therapy, surgery and adjuvant therapy with somatostatin analogs, fails in 25% of patients. There is no predictive factor of resistance to therapy. Read More

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http://dx.doi.org/10.1016/j.ebiom.2019.04.007DOI Listing
April 2019
1 Read

High-field Intraoperative Magnetic Resonance Imaging Increases the Extent of Resection and Progression-free Survival for Non-functioning Pituitary Adenomas.

World Neurosurg 2019 Apr 8. Epub 2019 Apr 8.

School of Medcine, Nankai University, Tianjin 300071, China; Department of Neurosurgery, Chinese PLA General Hospital, Beijing 100853, China. Electronic address:

Background: The impact of intraoperative magnetic resonance imaging (iMRI) on tumor control in endoscopic transsphenoidal surgery (TSS) for non-functioning pituitary adenomas (NFPAs) has not yet been completely characterized. This study assessed the impact of iMRI on gross total resection (GTR) rates and progression-free survival (PFS) at a mean follow-up of 62±9.4 months. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.04.001DOI Listing
April 2019
2.417 Impact Factor

MicroRNA-543 promotes cell invasion and impedes apoptosis in pituitary adenoma via activating the Wnt/β-catenin pathway by negative regulation of Smad7.

Biosci Biotechnol Biochem 2019 Apr 11:1-10. Epub 2019 Apr 11.

e Department of Neurosurgery , Weifang People's Hospital , Weifang , P. R. China.

Pituitary adenomas (PA) are commonly occurring benign neoplasms. Identification of molecular pathway resulting in pituitary tumorigenesis remains challenges in endocrine oncology. The present study was conducted with aim of investigating the role of microRNA-543 (miR-543) in PA development. Read More

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http://dx.doi.org/10.1080/09168451.2019.1591260DOI Listing
April 2019
1 Read

CCDN1 rs603965 polymorphism may serve as a genetic biomarker of brain tumor: A meta-analysis of 5,769 subjects.

Mol Genet Genomic Med 2019 Apr 10:e00655. Epub 2019 Apr 10.

Department of Neurosurgery, Ningbo No. 1 Hospital, Ningbo, Zhejiang, China.

Introduction: Some studies already tried to assess the associations between cyclin D1 (CCND1) polymorphisms and brain tumor. However, the results of these studies were not consistent. Thus, we performed the present meta-analysis to explore the relationship between CCND1 polymorphisms and brain tumor in a larger pooled population. Read More

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http://dx.doi.org/10.1002/mgg3.655DOI Listing

Cellular markers in corticotroph adenomas correlate with hormones-concerns on interpretation.

Endocrine 2019 Apr 8. Epub 2019 Apr 8.

Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 100730, Beijing, China.

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http://dx.doi.org/10.1007/s12020-019-01923-yDOI Listing

Clock genes and cancer development in particular in endocrine tissues.

Endocr Relat Cancer 2019 Apr 1. Epub 2019 Apr 1.

G Chrousos, Pediatrics, National and Kapodistrian University of Athens - Faculty of Medicine, Athens, Greece.

Circadian rhythms in central and peripheral level are operated by transcriptional/translational feedback loops involving a set of genes called 'clock genes' that are implicated in the development of several diseases including malignancies. Dysregulation of Clock system can affect cancer susceptibility by regulating DNA damage and repair mechanisms as well as apoptosis. A number of oncogenic pathways can be dysregulated via clock genes' epigenetic alterations including hypermethylation of clock genes' promoters or variants of clock genes. Read More

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http://dx.doi.org/10.1530/ERC-19-0094DOI Listing
April 2019
3 Reads

International consensus statement on endoscopic skull-base surgery: executive summary.

Int Forum Allergy Rhinol 2019 Apr 8. Epub 2019 Apr 8.

Department of Otolaryngology, School of Medicine, University of North Carolina,, Chapel Hill, NC.

Background: Endoscopic skull-base surgery (ESBS) is a rapidly growing discipline that often combines the expertise of otolaryngology-head and neck surgeons and neurosurgeons to provide care for these challenging conditions. As the field has grown, so too has the literature evaluating this surgical approach and the challenges and complications associated with these interventions. An international, multidisciplinary effort to critically evaluate and grade the current literature on ESBS has resulted in the International Consensus Statement on Endoscopic Skull Base Surgery (ICAR:SB). Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/alr.22327
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http://dx.doi.org/10.1002/alr.22327DOI Listing
April 2019
3 Reads

Socioeconomic Predictors of Pituitary Surgery.

Cureus 2019 Jan 25;11(1):e3957. Epub 2019 Jan 25.

Neurosurgery, Stanford University School of Medicine, Stanford, USA.

Background: There exists a lack of data on the effect of socioeconomic status (SES) on outcomes for pituitary tumors, which have been associated with significant morbidity. The goal of this population-level study is to investigate the role of SES on receiving treatment and survival in patients with pituitary tumors.

Methods: The Surveillance, Epidemiology, and End Results (SEER) program database from the National Cancer Institute was used to identify patients diagnosed with pituitary tumors between 2003 and 2012. Read More

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http://dx.doi.org/10.7759/cureus.3957DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436671PMC
January 2019
1 Read

Internal carotid artery aneurysms diagnosed after stereotactic radiosurgery for a growth hormone-secreting pituitary adenoma: a case report and literature review.

Acta Neurochir (Wien) 2019 Apr 6. Epub 2019 Apr 6.

Departments of Neurosurgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo Chuo-ku, Kumamoto, 860-8556, Japan.

Radiation therapy is associated with the subsequent development of cerebral aneurysms; however, stereotactic radiosurgery (SRS)-associated aneurysm cases have not been well documented, with only 18 cases reported to date. We present a case of intracranial aneurysms with the rupture occurring 20 years after SRS for a growth hormone-producing pituitary adenoma. This is the first report of aneurysms diagnosed following transsphenoidal surgery and SRS for pituitary adenoma. Read More

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http://dx.doi.org/10.1007/s00701-019-03840-5DOI Listing
April 2019
1 Read

Hybrid fluorescein-guided surgery for pituitary adenoma resection: a pilot study.

J Neurosurg 2019 04 5:1-9. Epub 2019 Apr 5.

Objective: The authors conducted a pilot study on hybrid fluorescein-guided surgery for pituitary adenoma resection and herein describe the feasibility and safety of this technique.

Methods: In this pilot study, the authors included all consecutive patients presenting with pituitary adenomas, functioning and nonfunctioning. They performed a hybrid fluorescein-guided surgical technique for tumor resection. Read More

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http://dx.doi.org/10.3171/2019.1.JNS181512DOI Listing
April 2019
3 Reads

Intraoperative MRI in transsphenoidal resection of invasive pituitary macroadenomas.

Neurosurg Rev 2019 Apr 4. Epub 2019 Apr 4.

Department of Neurosurgery, University of Ulm, Ludwig-Heilmeyerstr. 2, 89312, Günzburg, Germany.

The use of intraoperative MRI (iMRI) increases extent of resection in transsphenoidal pituitary surgery. Microsurgical and endoscopic techniques have been established as equal and standard surgical methods. The object of the current study was to evaluate the additional value of iMRI for resection of invasive pituitary adenomas. Read More

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http://dx.doi.org/10.1007/s10143-019-01102-7DOI Listing
April 2019
1 Read

ACTH-producing adenoma of the pituitary gland manifesting as severe insulin resistance.

J Surg Case Rep 2019 Mar 29;2019(3):rjz070. Epub 2019 Mar 29.

Campbell University, School of Osteopathic Medicine, Novant Health Presbyterian, Internal Medicine, Charlotte, NC, USA.

Pituitary adenomas are commonly benign neoplasms which may manifest with a wide variety of symptomatology. Typically, ACTH- producing tumors of the pituitary gland present with central fat deposition, abdominal striae, moon facies, buffalo hump, osteoporosis, hypertension, hirsutism, gonadal dysfunction, immunosuppression, and less commonly with hyperglycemia due to insulin resistance. We report the case of a 58-year-old male patient with an ACTH producing pituitary microadenoma and type 2 Diabetes Mellitus (DM) whose primary presenting symptom was increasing insulin resistance despite appropriate adjustments to his insulin therapy. Read More

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https://academic.oup.com/jscr/article/doi/10.1093/jscr/rjz07
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http://dx.doi.org/10.1093/jscr/rjz070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439515PMC
March 2019
6 Reads

Pituitary gigantism: a rare learning opportunity.

Arch Dis Child Educ Pract Ed 2019 Apr 4. Epub 2019 Apr 4.

Department of Endocrinology, Oxford Children's Hospital, Oxford, UK.

Introduction: Pituitary gigantism is a rare but significant paediatric condition with complexities surrounding diagnosis and management. Transsphenoidal surgery (TSS) is the treatment of choice; however, medical treatment is often considered as adjuvant therapy.

Case: A 10½ -year-old boy presented with tall stature and a height velocity of 11 cm/year. Read More

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http://ep.bmj.com/lookup/doi/10.1136/archdischild-2018-31628
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http://dx.doi.org/10.1136/archdischild-2018-316282DOI Listing
April 2019
4 Reads

miR-93-5p targets Smad7 to regulate the transforming growth factor-β1/Smad3 pathway and mediate fibrosis in drug-resistant prolactinoma.

Brain Res Bull 2019 Apr 1;149:21-31. Epub 2019 Apr 1.

Department of Neurosurgery and Pituitary Tumor Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China. Electronic address:

Prolactinoma is a common subtype of pituitary tumors. Dopamine receptor agonists are the preferred treatment for prolactinoma; however, with this therapy, drug resistance often occurs. In our previous work, we found that partial resistant prolactinomas showed increased fibrosis and that the transforming growth factor (TGF)-β1/Smad3 signaling pathway mediated fibrosis and was involved in drug resistance. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03619230183101
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http://dx.doi.org/10.1016/j.brainresbull.2019.03.013DOI Listing
April 2019
4 Reads

Differentially Expressed miRNAs Influence Metabolic Processes in Pituitary Oncocytoma.

Neurochem Res 2019 Apr 3. Epub 2019 Apr 3.

Momentum Hereditary Endocrine Tumours Research Group, Semmelweis University, 46 Szentkiralyi Street, Budapest, 1088, Hungary.

Spindle cell oncocytomas (SCO) of the pituitary are rare tumors accounting for 0.1-0.4% of all sellar tumors. Read More

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http://dx.doi.org/10.1007/s11064-019-02789-2DOI Listing

Phosphodiesterases and cAMP Pathway in Pituitary Diseases.

Front Endocrinol (Lausanne) 2019 19;10:141. Epub 2019 Mar 19.

Department of Internal Medicine, Federal University of Minas Gerais, Belo Horizonte, Brazil.

Human phosphodiesterases (PDEs) comprise a complex superfamily of enzymes derived from 24 genes separated into 11 PDE gene families (PDEs 1-11), expressed in different tissues and cells, including heart and brain. The isoforms PDE4, PDE7, and PDE8 are specific for the second messenger cAMP, which is responsible for mediating diverse physiological actions involving different hormones and neurotransmitters. The cAMP pathway plays an important role in the development and function of endocrine tissues while phosphodiesterases are responsible for ensuring the appropriate intensity of the actions of this pathway by hydrolyzing cAMP to its inactive form 5'-AMP. Read More

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http://dx.doi.org/10.3389/fendo.2019.00141DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433792PMC
March 2019
3 Reads

Little Insights from Big Data: Cerebrospinal Fluid Leak After Skull Base Surgery and the Limitations of Database Research.

World Neurosurg 2019 Mar 28. Epub 2019 Mar 28.

Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota, USA; Department of Otolaryngology-Head and Neck Surgery, Mayo Clinic, Rochester, Minnesota, USA. Electronic address:

Background: Cerebrospinal fluid (CSF) leak is a frustrating complication of skull base surgery. Published methodologies using national surgical databases to assess CSF leak have not accounted for variability between skull base operations.

Objective: Our goal was to attempt the development of a novel framework for adapting big data techniques to skull base surgery and assess the reliability of corresponding data manipulations. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.03.207DOI Listing
March 2019
2 Reads

Golden-angle radial sparse parallel (GRASP) MRI in clinical routine detection of pituitary microadenomas: First experience and feasibility.

Magn Reson Imaging 2019 Mar 27;60:38-43. Epub 2019 Mar 27.

Department of Neuroradiology, Clinical Neuroscience Center, University Hospital Zurich, University of Zurich, Zurich, Switzerland; Division of Diagnostic and Interventional Neuroradiology, Department of Radiology, University Hospital Basel, University of Basel, Basel, Switzerland.

Background and purpose To demonstrate the clinical feasibility of a novel MRI pulse sequence, Golden-angle radial sparse parallel MRI (GRASP) through comparison to the current imaging technique, dynamic T1- weighted contrast enhanced (DCE) imaging in terms of image quality and lesion depiction in the detection of microlesions (microadenomas and cysts) of the pituitary gland.

Materials And Methods: 16 patients (11 microadenomas, 5 cysts) underwent two MRI examinations (Siemens 1.5T and 3T) on separate dates, one using standard DCE (temporal resolution 30 s) and the other using GRASP (temporal resolution of 4. Read More

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http://dx.doi.org/10.1016/j.mri.2019.03.015DOI Listing

Vision outcomes in early vs late surgical intervention of pituitary apoplexy: a meta-analysis.

World Neurosurg 2019 Mar 25. Epub 2019 Mar 25.

UC Irvine Department of Neurological Surgery, 101 The City Drive South, Orange, CA 92868, USA. Electronic address:

Background: Pituitary apoplexy (PA) is defined by hemorrhage and necrosis of the pituitary gland, often acute in onset, and frequently in the setting of an existing pituitary adenoma.

Objective: Conduct a meta-analysis of the available literature on vision outcomes following surgical intervention for PA based on the timing from apoplexy to surgery (ATS).

Methods: A thorough literature search of the published English-language literature was performed in PubMed, Ovid, and Cochrane databases using the keywords ("pituitary apoplexy") and ("surgery" or "vision") from database inception to August 2018 was conducted. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.03.133DOI Listing
March 2019
1 Read

Demographic Characteristics, Etiology, and Comorbidities of Patients with Cushing's Syndrome: A 10-Year Retrospective Study at a Large General Hospital in China.

Int J Endocrinol 2019 19;2019:7159696. Epub 2019 Feb 19.

Key Laboratory of Endocrinology of National Health Commission of People's Republic of China, Beijing 100730, China.

Purpose: To investigate the demographic characteristics, etiology, and comorbidities of Cushing's syndrome (CS) patients at a large medical center in China.

Methods: Records on CS patients discharged from 2008 to 2017 were retrieved from the hospital discharge abstract database (DAD) using ICD-10 codes. Demographic characteristics, etiology, and comorbidity data were analyzed. Read More

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http://dx.doi.org/10.1155/2019/7159696DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399544PMC
February 2019
2 Reads
1.515 Impact Factor

Attenuation of MAMLD1 Expression Suppresses the Growth and Migratory Properties of Gonadotroph Pituitary Adenomas.

Authors:
Junhui Qi Wei Ni

Pathol Oncol Res 2019 Mar 25. Epub 2019 Mar 25.

Department of Neurosurgery, The Third Affiliated Hospital of Kunming Medical University, No. 519, Kunzhou Road, Kunming, Yunnan Province, 650118, People's Republic of China.

Gonadotroph pituitary adenomas (GPAs) constitute approximately 15-40% of pituitary tumors. Some GPAs can be highly infiltrative, making full surgical resection challenging and increasing the risk of recurrence. The transcriptional co-activator Mastermind-Like Domain Containing 1 (MAMLD1, CXorf6, F18) is involved in regulating signaling pathways important in pituitary tumorigenesis, including the Notch signaling pathway. Read More

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http://dx.doi.org/10.1007/s12253-019-00615-2DOI Listing

Retinal Nerve Fiber Layer Thickness Measurement for Predicting Visual Outcome after Transsphenoidal Surgery: Optic Disc Atrophy Is Not the Deciding Indicator.

World Neurosurg 2019 Mar 22. Epub 2019 Mar 22.

Department of Neurosurgery, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan.

Background: Postoperative visual recovery is a major concern after transsphenoidal surgery. Optical coherence tomography (OCT) can visualize the anatomy of the retina, and retinal nerve fiber layer (RNFL) thinning reflects loss of optic nerve axons. Visual-evoked potential (VEP) is an electrophysiological response that confirms the nerve conductance. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.03.143DOI Listing

Outcomes of Surgical Repair of Skull Base Defects Following Endonasal Pituitary Surgery: A Retrospective Observational Study.

Indian J Otolaryngol Head Neck Surg 2019 Mar 15;71(1):66-70. Epub 2018 Oct 15.

1Department of ENT, Head and Neck Surgery, Sri Ramachandra Medical College and Research Institute, Chennai, Tamil Nadu 600116 India.

Skull base defects following endonasal surgery for pituitary macroadenoma need to be addressed during the surgery to prevent serious postoperative complications like cerebrospinal fluid (CSF) leak. The objective of this study is to assess the incidence of CSF leak following pituitary surgery and the methods of effective skull base repair. This is a retrospective observational study conducted in a tertiary care hospital after obtaining due clearance from the Institutional ethics committee. Read More

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http://dx.doi.org/10.1007/s12070-018-1511-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6401034PMC
March 2019
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Healthcare utilization and costs among patients with non-functioning pituitary adenomas.

Endocrine 2019 Mar 22. Epub 2019 Mar 22.

Department of Orthopaedics, Rehabilitation Medicine and Physical Therapy, Leiden University Medical Center, Leiden, The Netherlands.

Purpose: Non-functioning pituitary adenomas (NFPA) have a substantial impact on patients' health status, yet research on the extent of healthcare utilization and costs among these patients is scarce. The objective was to determine healthcare usage, associated costs, and their determinants among patients treated for an NFPA.

Methods: In a cross-sectional study, 167 patients treated for an NFPA completed four validated questionnaires. Read More

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http://dx.doi.org/10.1007/s12020-019-01847-7DOI Listing
March 2019
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PITX2 Expression in Non-functional Pituitary Neuroendocrine Tumor with Cavernous Sinus Invasion.

Endocr Pathol 2019 Mar 22. Epub 2019 Mar 22.

Department of Neurosurgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.

Although most pituitary neuroendocrine tumors (PitNETs) show benign behavior, a significant number of PitNETs exhibit an aggressive course including cavernous sinus (CS) invasion. To date, the cause of CS invasion has not been fully elucidated. In this study, we analyzed the relationship between CS invasion in PitNETs and the expression of PITX2 and SNAIL1, which are the transcription factors associated with the morphogenesis of pituitary gland. Read More

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http://dx.doi.org/10.1007/s12022-019-9573-8DOI Listing

Fractionated CyberKnife Stereotactic Radiotherapy for Perioptic Pituitary Adenomas.

World Neurosurg 2019 Mar 19. Epub 2019 Mar 19.

Department of Neurological Surgery, University of Texas Southwestern Medical Center, Dallas, Texas, USA.

Objective: Stereotactic radiosurgery (SRS) is the reference standard for radiotherapy for pituitary adenomas but has been limited to lesions with sufficient distance (i.e., >3 mm) from the optic apparatus. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.03.102DOI Listing
March 2019
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Results of a prospective multicenter controlled study comparing surgical outcomes of microscopic versus fully endoscopic transsphenoidal surgery for nonfunctioning pituitary adenomas: the Transsphenoidal Extent of Resection (TRANSSPHER) Study.

J Neurosurg 2019 03 22:1-11. Epub 2019 Mar 22.

Department of Neurological Surgery, University of Washington, Seattle, Washington.

OBJECTIVE: Many surgeons have adopted fully endoscopic over microscopic transsphenoidal surgery for nonfunctioning pituitary tumors, although no high-quality evidence demonstrates superior patient outcomes with endoscopic surgery. The goal of this analysis was to compare these techniques in a prospective multicenter controlled study. METHODS: Extent of tumor resection was compared after endoscopic or microscopic transsphenoidal surgery in adults with nonfunctioning adenomas. Read More

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http://dx.doi.org/10.3171/2018.11.JNS181238DOI Listing
March 2019
2 Reads

Elevated insulin-like growth factor-1 in Cushing's disease.

Clin Endocrinol (Oxf) 2019 Mar 22. Epub 2019 Mar 22.

Department of Diabetes and Endocrinology, Princess Alexandra Hospital, Brisbane, Queensland, Australia.

Objective: To determine if patients with untreated Cushing's disease have higher serum insulin-like growth factor-1 (IGF-1) compared to matched controls, and if IGF-1 decreases following remission of Cushing's disease.

Design: Retrospective case-control study matching Cushing's disease cases to control patients for adenoma size, age, sex, diabetic and gonadal status, body mass index and serum IGF-1 measured within one year. Paired analysis of pre-operative (untreated) and >3 months post-operative (remission) serum IGF-1 for cases. Read More

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http://dx.doi.org/10.1111/cen.13974DOI Listing

[Evaluation of transsphenoidal adenomectomy outcomes in acromegaly using different remission criteria].

Zh Vopr Neirokhir Im N N Burdenko 2019;83(1):98-104

Almazov National Medical Research Center, St. Petersburg, Russia.

For a long time, surgical removal of somatotropinoma using the transsphenoidal approach has been the first stage of treatment in most acromegaly patients. For the past decades, the efficacy criteria for surgical treatment of acromegaly have significantly changed, which requires appropriate correction.

Purpose: We aimed to evaluate the results of transsphenoidal adenomectomy in acromegaly patients using various criteria for disease remission. Read More

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http://dx.doi.org/10.17116/neiro20198301198DOI Listing
January 2019
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Acromegaly.

Nat Rev Dis Primers 2019 Mar 21;5(1):20. Epub 2019 Mar 21.

Dipartimento di Medicina Clinica e Chirurgia, Sezione di Endocrinologia, University Federico II, Naples, Italy.

Acromegaly is characterized by increased release of growth hormone and, consequently, insulin-like growth factor I (IGF1), most often by a pituitary adenoma. Prolonged exposure to excess hormone leads to progressive somatic disfigurement and a wide range of systemic manifestations that are associated with increased mortality. Although considered a rare disease, recent studies have reported an increased incidence of acromegaly owing to better disease awareness, improved diagnostic tools and perhaps a real increase in prevalence. Read More

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http://dx.doi.org/10.1038/s41572-019-0071-6DOI Listing
March 2019
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The Intriguing Case of a Double Pituitary Adenoma.

World Neurosurg 2019 Mar 18. Epub 2019 Mar 18.

Department of Medicine Division of Endocrinology, Emory University School of Medicine, Atlanta, GA; Department of Neurological Surgery, Emory University School of Medicine, Atlanta, GA. Electronic address:

Background: When distinct pituitary hypersecretory manifestations coexist, the differential diagnosis includes plurihormonal or double pituitary adenomas. We describe a rare case of hypercortisolemia and hyperprolactinemia caused by two non-contiguous adenomas that required two surgeries.

Case Presentation: A 37-year-old woman presented with 6-month of weight gain, amenorrhea, joint pain, leg swelling and skin changes. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.02.242DOI Listing
March 2019
3 Reads

A prospective study of headache and neuropeptides in patients with pituitary adenomas.

Cephalalgia 2019 Mar 21:333102419839963. Epub 2019 Mar 21.

1 Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Objective: To evaluate clinical criteria for headache associated with pituitary adenoma (HaPA) in the International Classification of Headache Disorders (ICHD) 3rd edition version criteria and further determine whether elevations of plasma calcitonin gene-related peptide and pituitary adenylate cyclase-activating peptide 1-38 (PACAP1-38) concentration contribute to HaPA.

Methods: Demographic and clinical features of consecutive patients with pituitary adenoma were recorded. Plasma calcitonin gene-related peptide and PACAP1-38 concentrations in pituitary adenoma patients within 72 h pre- and post-operation were measured. Read More

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http://dx.doi.org/10.1177/0333102419839963DOI Listing

Plurihormonal Pit-1 lineage adenoma presenting as meningitis with recurrence after somatostatin analogue.

Endocrinol Diabetes Metab Case Rep 2019 Mar 21;2019. Epub 2019 Mar 21.

Oxford Centre for Endocrinology, Diabetes and Metabolism, Churchill Hospital, Oxford, UK.

A 21 year-old woman was found to have a pituitary macroadenoma following an episode of haemophilus meningitis. Biochemical TSH and GH excess was noted, although with no clear clinical correlates. She was treated with a somatostatin analogue (SSA), which restored the euthyroid state and controlled GH hypersecretion, but she re-presented with a further episode of cerebrospinal fluid (CSF) leak and recurrent meningitis. Read More

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http://dx.doi.org/10.1530/EDM-18-0130DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6432976PMC
March 2019
1 Read