37,102 results match your criteria Pituitary Adenoma


Pasireotide (SOM230): a novel pituitary-targeted medical therapy for the treatment of patients with Cushing's disease.

Expert Rev Endocrinol Metab 2012 Sep;7(5):491-502

a Seattle Pituitary Center, Swedish Neuroscience Institute, Seattle, WA, USA.

Cushing's disease (CD) is a rare and debilitating condition resulting from extended exposure to excessive glucocorticoids caused by an adrenocorticotropic hormone-secreting pituitary adenoma. First-line treatment for most patients with CD is trans-sphenoidal adenomectomy. Postsurgical remission remains problematic; however, due to the difficulty of removing the tumor. Read More

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http://dx.doi.org/10.1586/eem.12.49DOI Listing
September 2012

Diagnosis and treatment of prolactinomas.

Expert Rev Endocrinol Metab 2009 Mar;4(2):135-142

b 3rd Department of Medicine, 1st Medical Faculty, U nemocnice 1, 128 02 Praha 2, Czech Republic.

Prolactinomas account for approximately 40% of all pituitary adenomas. Hyperprolactinemia causes hypogonadism, infertility and galactorrhea. Macroprolactinomas may cause signs of local expansion, such as headache, visual field defects and paresis of oculomotor nerves during suprasellar and parasellar extensions. Read More

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http://dx.doi.org/10.1586/17446651.4.2.135DOI Listing

Resting state functional connectivity in neurosurgical patients under propofol anesthesia: detectability and variability between patients and between sessions.

World Neurosurg 2019 Feb 16. Epub 2019 Feb 16.

International Neuroscience Institute, Department of Neurosurgery Rudolf-Pichlmayr-Straße 4 D - 30625 Hannover Germany; Leibniz Institute, Germany.

Background: Intraoperative assessment of the functional connectivity (FC) provides a new possibility of mapping the eloquent brain region before, during, and after tumor resection. a systematic analysis of the detectability of FC and its variation between subjects and session.

Methods: the FC was analyzed in 10 pituitary adenoma patients under propofol anesthesia before and after tumor resection. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.01.266DOI Listing
February 2019

Non-neuroendocrine neoplasms of the pituitary region.

J Clin Endocrinol Metab 2019 Feb 19. Epub 2019 Feb 19.

Centre for Endocrinology, Barts and the London School of Medicine, Queen Mary University of London, London, United Kingdom.

Context: Although the majority of sellar lesions are related to pituitary adenomas, the region gives rise to a variety of neoplasms that can be associated with substantial morbidity and/or mortality.

Evidence Acquisition: Information from reviews and guidelines of relevant societies dealing with such neoplasms, and articles that have provided new developments which made important contributions in their pathogenesis and treatment up to 2018, were obtained: public indexes such as PubMed/MEDLINE were used with the search items.

Evidence Synthesis: Sellar neoplasms have a worse outcome than pituitary adenomas that is related not only to their natural history but also to side effects of therapies and evolving endocrine and/or hypothalamic deficiencies. Read More

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http://dx.doi.org/10.1210/jc.2018-01871DOI Listing
February 2019

Sequential Treatment of a Large Pituitary Corticotroph Neoplasm and Associated Neurological Signs in a Dog.

J Am Anim Hosp Assoc 2019 Mar/Apr;55(2):e55202. Epub 2019 Jan 17.

From the Department of Veterinary Medical Sciences, University of Bologna, Bologna, Italy (S.D.M., F.F., L.M., G.G., R.S. L.P.); Department of Pathobiology (G.C.M.G.) and Department of Clinical Sciences of Companion Animals (M.A.T., B.P.M.), Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands; and Clinica Veterinaria dell'Orologio, Sasso Marconi, Italy (F.R.).

No standardized treatment guidelines are reported in veterinary medicine for dogs with large pituitary corticotroph neoplasms causing neurological signs, and such dogs usually have a short overall survival. When these dogs undergo pituitary surgery and the tumor regrows there are few reports of subsequent treatments. A 7 yr old male Maltese diagnosed with pituitary-dependent hypercortisolism developed seizures in conjunction with a large pituitary corticotroph adenoma and underwent transsphenoidal hypophysectomy. Read More

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http://dx.doi.org/10.5326/JAAHA-MS-6831DOI Listing
January 2019

Neurocytoma mimicking macroadenoma.

Surg Neurol Int 2019 21;10. Epub 2019 Jan 21.

Department of Surgery and Anatomy, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.

Background: Intraventricular and extraventricular central neurocytomas (CN) are equally frequent among 20-40-year-old men and women. However, sellar and suprasellar extraventricular CN are extremely rare, with only 12 reported cases.

Case Description: The authors report the case of a Brazilian 27-year-old man who presented with progressive vision loss during the last 4 years and serious bilateral keratoconus. Read More

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http://dx.doi.org/10.4103/sni.sni_387_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357540PMC
January 2019

Hyperadrenocorticism Caused by a Pituitary Ganglioglioma in a Dog.

Vet Pathol 2019 Feb 17:300985819829530. Epub 2019 Feb 17.

5 Laboratory of Veterinary Surgery, Department of Veterinary Clinical Medicine, Faculty of Veterinary Medicine, School of Veterinary Medicine, Nippon Veterinary and Life Science University, Musashino-shi, Tokyo, Japan.

An 11-year-old castrated male Chihuahua dog was presented with complaints of polyuria, polydipsia, abdominal enlargement, and alopecia. Hyperadrenocorticism was diagnosed on the basis of clinical signs, blood tests, adrenocorticotropin-stimulation test results, and an elevated serum adrenocorticotropin concentration. Contrast-enhanced magnetic resonance imaging showed that the pituitary gland was enlarged, compatible with a pituitary macroadenoma. Read More

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http://dx.doi.org/10.1177/0300985819829530DOI Listing
February 2019

Small Cell Lung Cancer with Pituitary Metastasis Presenting as Secondary Adrenal Insufficiency: A Case Report and Literature Review.

Am J Case Rep 2019 Feb 17;20:207-211. Epub 2019 Feb 17.

Department of Endocrinology, University of California San Francisco, San Francisco, CA, USA.

BACKGROUND Pituitary gland metastasis is rarely the initial presentation of metastatic cancer. Most cases of pituitary gland metastasis are asymptomatic with diabetes insipidus being the most common symptomatic presentation. It can rarely present with symptoms of hormone underproduction such as secondary adrenal insufficiency. Read More

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http://dx.doi.org/10.12659/AJCR.913388DOI Listing
February 2019
1 Read

The dark side of the (half) Moon.

Surv Ophthalmol 2019 Feb 14. Epub 2019 Feb 14.

Save Sight Institute, The University of Sydney, Sydney, Australia.

A 71-year-old man was referred to Neuro-Ophthalmology for evaluation of reading problems associated to pituitary adenoma. Perimetry showed a right temporal crescent syndrome ("half moon" syndrome) suggesting left occipital disease. Brain MRI, electroencephalogram and CSF examination (14-3-3 protein) were consistent with a diagnosis of Creutzfeldt-Jakob disease. Read More

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http://dx.doi.org/10.1016/j.survophthal.2019.02.001DOI Listing
February 2019

Rare Case of Sellar and Suprasellar Metastasis from Ewing's Sarcoma of Tibia.

J Neurosci Rural Pract 2019 Jan-Mar;10(1):158-161

Department of Neurosurgery, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India.

We hereby report a case of metastatic Ewing's sarcoma presenting with rapid-onset total ophthalmoplegia, optic atrophy, and right temporal hemianopia. Comprehensive ophthalmic and neurological evaluation with targeted radioimaging revealed a tumor mass centered over the sella, compressing optic chiasma, extending to involve the left cavernous sinus and the left orbital apex. Whole-body imaging revealed the evidence of multifocal lung and mediastinal metastasis with focal lytic defect in the left femoral head. Read More

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http://dx.doi.org/10.4103/jnrp.jnrp_139_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338001PMC
February 2019

Perioperative holistic care more significantly reduces levels of anxiety and depression of pituitary tumor patients versus conventional care.

Medicine (Baltimore) 2019 Feb;98(7):e14411

Department of Neurosurgery, The First Affiliated Hospital of Anhui Medical University.

To compare the effect of perioperative holistic care versus conventional care on the levels of anxiety and depression of pituitary tumor patients at a single tertiary care center in China.We enrolled 100 patients who underwent transnaso-sphenoidal microsurgical resection of pituitary tumor at our institution between January 2017 and December 2017. The patients were assigned to the conventional care group (n = 50) and the holistic care group by the order of admission. Read More

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http://dx.doi.org/10.1097/MD.0000000000014411DOI Listing
February 2019

Hormonal imbalance and pituitary adenoma during antipsychotic treatment in an adolescent with bipolar affective disorder.

Riv Psichiatr 2019 Jan-Feb;54(1):37-39

Child and Adolescent Psychiatry Department, University of Medicine and Pharmacy "Carol Davila", Bucharest, Romania.

In this paper we present the case of a female teenager patient who was diagnosed with bipolar affective disorder and during psychotropic treatment with risperidone, the prolactin levels ranged between 55 ng/mL and 85 ng/mL at monthly repeated dosing. During this period, the patient presented somatic alterations in her state of health. The patient benefited from brain imaging, which revealed that in sella turcica is distinguished a well-defined and relatively homogeneous formation, measuring approximately 11/8 mm, suggestive of a pituitary adenoma. Read More

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http://dx.doi.org/10.1708/3104.30939DOI Listing
February 2019
1 Read

Outcomes of three-Tesla magnetic resonance imaging for the identification of pituitary adenoma in patients with Cushing's disease.

Endocr J 2019 Feb 14. Epub 2019 Feb 14.

Department of Hypothalamic and Pituitary Surgery, Toranomon Hospital, Tokyo 105-8470, Japan.

Pituitary adenoma has been reported to be detectable in only 36-63% of Cushing's disease (CD) patients by magnetic resonance imaging (MRI). In this study, we investigate the outcomes and problems associated with tumor identification using 3-Tesla (3-T) MRI, which provides clearer images than ≤1.5-T MRI, in 115 patients who were initially diagnosed with CD. Read More

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http://dx.doi.org/10.1507/endocrj.EJ18-0458DOI Listing
February 2019
1 Read

Acromegaly associated with GIST, non-small cell lung cancer, clear cell renal cancer, myeloma multiplex, medulla oblongata tumor, adrenal adenoma and follicular thyroid nodules.

Endokrynol Pol 2019 Feb 11. Epub 2019 Feb 11.

Dept. of Endocrinology, Diabetes and Isotope Therapy, Medical University Wroclaw, Pasteura 4, 50-367 Wrocłąw, Poland.

Background: Acromegaly is associated with increased growth hormone (GH) and insulin-like growth factor-I (IGF-I) secretion which may support tumor development and growth.

Case Presentation: A 68-year old woman was diagnosed with acromegaly due to typical clinical and hormonal characteristics. While a contrast-enhanced MRI at diagnosis did not reveal a pituitary adenoma, a 5 mm lesion was identified on repeat scanning 13 months later. Read More

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http://dx.doi.org/10.5603/EP.a2019.0005DOI Listing
February 2019
5 Reads

Coexistence of intracranial solitary fibrous tumor/hemangiopericytoma and right middle cerebral artery aneurysm.

J Surg Case Rep 2019 Jan 31;2019(1):rjz013. Epub 2019 Jan 31.

Department of Radiology, Section of Neuroradiology Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, ROC.

Intracranial solitary fibrous tumors are rare mesenchymal neoplasms originating in the meninges and constitute a heterogeneous group of rare spindle cell tumors that include benign and malignant neoplasms of which hemangiopericytoma is nowadays considered a cellular phenotypic variant. From literatures, the incidence of coexistence of brain tumors and intracranial aneurysms is ~0.7-5. Read More

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http://dx.doi.org/10.1093/jscr/rjz013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354750PMC
January 2019
1 Read

Exacerbation of Cushing's syndrome during pregnancy: stimulation of a cortisol-secreting adrenocortical adenoma by ACTH originating from the foeto-placental unit.

Endocrinol Diabetes Metab Case Rep 2019 Feb 7;2019. Epub 2019 Feb 7.

A 29-year-old G4A3 woman presented at 25 weeks of pregnancy with progressive signs of Cushing's syndrome (CS), gestational diabetes requiring insulin and hypertension. A 3.4 × 3. Read More

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http://dx.doi.org/10.1530/EDM-18-0115DOI Listing
February 2019
1 Read

Molecular Network Basis of Invasive Pituitary Adenoma: A Review.

Authors:
Qi Yang Xuejun Li

Front Endocrinol (Lausanne) 2019 24;10. Epub 2019 Jan 24.

Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, China.

Cases with pituitary adenoma comprise 10-25% of intracranial neoplasm, being the third most common intracranial tumor, most of the adenomas are considered to be benign. About 35% of pituitary adenomas are invasive. This review summarized the known molecular basis of the invasiveness of pituitary adenomas. Read More

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http://dx.doi.org/10.3389/fendo.2019.00007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6353782PMC
January 2019

Arterial thrombosis as primary presentation of endogenous Cushing's syndrome.

BMJ Case Rep 2019 Feb 6;12(2). Epub 2019 Feb 6.

Department of Internal Medicine, Christian Medical College, Vellore, Tamil Nadu, India.

Cushing's syndrome is known to present with a characteristic set of clinical manifestations and complications, well described in literature. However, hypercoagulability remains an under recognised entity in Cushing's syndrome. A 31-year-old woman from Southern India presented with history of fever, left upper quadrant pain and progressive breathing difficulty for 3 weeks. Read More

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http://dx.doi.org/10.1136/bcr-2018-227491DOI Listing
February 2019
17 Reads

Pre-operative MRI predictors of hormonal remission status post pituitary adenoma resection.

Clin Imaging 2019 Jan 25;55:29-34. Epub 2019 Jan 25.

Department of Radiology and Imaging Sciences, Emory University School of Medicine, 100 Woodruff Circle, Atlanta, GA 30322, United States of America. Electronic address:

Introduction: Contrast-enhanced (CE) Constructive Interference in Steady State (CISS) and Volumetric Interpolated Breath-hold Examination (VIBE) are MRI sequences used to improve the detection of pituitary adenomas and adjacent cranial nerves. The purpose of this study was to assess image quality and identify imaging predictors of postoperative hormonal remission of functioning pituitary adenomas using CE-T1 weighted image (WI), T2WI, CE-CISS, and CE-VIBE MRI sequences.

Materials And Methods: Patients with pre-operative CE-T1WI, T2WI, CE-CISS, and CE-VIBE pituitary MRI sequences were included in this institutional retrospective review. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08997071193002
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http://dx.doi.org/10.1016/j.clinimag.2019.01.020DOI Listing
January 2019
7 Reads

The effect of somatostatin analogues on Ki-67 levels in GH-secreting adenomas.

Growth Horm IGF Res 2019 Jan 30;45:1-5. Epub 2019 Jan 30.

Department of Neurosurgery, Kocaeli University Faculty of Medicine, Umuttepe Kocaeli, Turkey.

Purpose: Somatostatin analogues (SSAs) can slow down the growth of neuroendocrine tumors. However, the mechanism remains unclear. Recent studies on patients with acromegaly suggest that SSAs may induce apoptosis, increase autophagy, and decrease cell proliferation of pituitary adenoma. Read More

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http://dx.doi.org/10.1016/j.ghir.2019.01.001DOI Listing
January 2019

Expression and methylation status of LAMA2 are associated with the invasiveness of nonfunctioning PitNET.

Ther Adv Endocrinol Metab 2019 29;10:2042018818821296. Epub 2019 Jan 29.

Department of Neurosurgery, Shenzhen People's Hospital, Shenzhen, China; The Second Affiliated Hospital of Dalian Medical University, Dalian, China.

The laminin subunit alpha 2 (LAMA2) gene encodes an alpha 2 chain, which constitutes one of the subunits of laminin 2 (merosin) and laminin 4 (s-merosin). In the current study, we investigated the relationship between LAMA2 promoter methylation status and the invasiveness of clinically nonfunctioning pituitary adenomas (PitNETs). Specimens from patients with nonfunctioning PitNET were classified into three groups according to preoperative computed tomography (CT)/magnetic resonance imaging findings: a normal group ( = 6), non-invasive group ( = 11) and invasive group ( = 6). Read More

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http://dx.doi.org/10.1177/2042018818821296DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351710PMC
January 2019

Delayed postoperative hyponatremia after endoscopic transsphenoidal surgery for pituitary adenoma.

Acta Neurochir (Wien) 2019 Feb 5. Epub 2019 Feb 5.

Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-0914, Japan.

Background: Hyponatremia generally occurs after transsphenoidal surgery (TSS) in a delayed fashion. Most patients with delayed postoperative hyponatremia (DPH) are asymptomatic or only express non-specific symptoms; consequently, DPH is associated with prolonged hospitalization. No consensus has been reached on which patients are at greatest risk of developing DPH. Read More

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http://dx.doi.org/10.1007/s00701-019-03818-3DOI Listing
February 2019
2 Reads

[Complications after endoscopic endonasal transsphenoidal removal of pituitary adenomas].

Zh Vopr Neirokhir Im N N Burdenko 2018 ;82(6):105-113

Burdenko Neurosurgical Institute, Moscow, Russia.

The use of endoscopic technique has significantly extended the indications for surgery using the transsphenoidal approach. Currently, more than 90% of pituitary adenomas are operated on transsphenoidally. Transnasal removal of giant pituitary adenomas has become possible. Read More

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http://dx.doi.org/10.17116/neiro201882061105DOI Listing
January 2018
1 Read

[Clinical and functional characteristics of giant pituitary adenomas in the population of patients in the Moscow region].

Zh Vopr Neirokhir Im N N Burdenko 2018 ;82(6):76-81

Moscow Regional Researh and Clinical Institute, Moscow, Russia.

Benign pituitary tumors are the most common sellar neoplasms. Lesions larger than 39 mm in the maximum dimension are called giant. They are rare, and, therefore, there are few data on the clinical and morphological features of giant pituitary tumors with different hormonal activity. Read More

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http://dx.doi.org/10.17116/neiro20188206176DOI Listing
January 2018
1 Read

[Etiology and diagnostics of compressive optic neuropathies].

Vestn Oftalmol 2018 ;134(6):72-82

Research Institute of Eye Diseases, 11A Rossolimo St., Moscow, Russian Federation, 119021.

Purpose: To determine the causes and study the clinical manifestations of compressive optic neuropathy (CON).

Material And Methods: The study included 24 male and 36 female patients with CON (in total 60 patients, 97 eyes). All patients underwent standard ophthalmic examination, as well as computer perimetry, magnetic resonance imaging (MRI), and/or computed tomography (CT) of the brain and orbit and magnetic resonance angiography (MRA). Read More

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http://dx.doi.org/10.17116/oftalma201813406172DOI Listing
January 2018
1 Read

ENDOCRINE OUTCOMES OF TRANS-SPHENOIDAL SURGERY FOR PITUITARY APOPLEXY VERSUS ELECTIVE SURGERY FOR PITUITARY ADENOMA.

Endocr Pract 2019 Jan 18. Epub 2019 Jan 18.

Department of Neurological Surgery.

Objective: To determine the rate of hormone replacement therapy (HRT) after transsphenoidal surgery (TSS) for pituitary apoplexy (PA) vs. elective resection of a null cell (NC) macroadenoma.

Methods: A retrospective cohort study was performed. Read More

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http://dx.doi.org/10.4158/EP-2018-0488DOI Listing
January 2019
1 Read

Analysis of pituitary adenoma expression patterns suggests a potential role for the NeuroD1 transcription factor in neuroendocrine tumor-targeting therapies.

Oncotarget 2019 Jan 8;10(3):289-312. Epub 2019 Jan 8.

Almazov National Medical Research Center, St. Petersburg, Russia.

NeuroD1's roles in the pathogenesis of pituitary adenomas and in the biology of the normal adult pituitary gland have been insufficiently researched. Much of the work investigating its expression patterns has yielded contradictory results.

Objective: morphological study of NeuroD1 transcription factor expression in different types of pituitary adenomas and in normal adult human pituitary glands. Read More

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http://dx.doi.org/10.18632/oncotarget.26513DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349459PMC
January 2019

miR-16 regulates proliferation and apoptosis of pituitary adenoma cells by inhibiting HMGA2.

Oncol Lett 2019 Feb 28;17(2):2491-2497. Epub 2018 Dec 28.

Department of Neurology, Hongqi Hospital, MuDanJiang Medical University, Mudanjiang, Heilongjiang 157000, P.R. China.

Previous studies have revealed that elevated expression of high mobility group A2 (HMGA2) is closely associated with the occurrence of pituitary adenomas (PAs). The expression of microRNA (miR)-16 is deregulated in PA tissues. Bioinformatics analysis has demonstrated that there is a complementary region between seed region of miR-16 and 3'-untranslated region (3'-UTR) of HMGA2 gene. Read More

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http://dx.doi.org/10.3892/ol.2018.9872DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350189PMC
February 2019

In Reply to the Letter to the Editor "Craniopharyngioma: 10 Selected Works Which Provide Comprehensive and Valuable Insight into These Complex Tumors".

World Neurosurg 2019 02;122:713-714

Department of Neurological Surgery, Loyola University Stritch School of Medicine, Maywood, Illinois, USA; Department of Otolaryngology, Loyola University Stritch School of Medicine, Maywood, Illinois, USA; Department of Neurological Surgery, Edward Hines, Jr. VA Hospital, Hines, Illinois, USA.

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http://dx.doi.org/10.1016/j.wneu.2018.10.223DOI Listing
February 2019
1 Read
2.417 Impact Factor

Craniopharyngioma: 10 Selected Works That Provide Comprehensive and Valuable Insight into These Complex Tumors.

World Neurosurg 2019 02;122:710-712

Department of Neurosurgery, Ramón y Cajal University Hospital, Madrid, Spain.

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http://dx.doi.org/10.1016/j.wneu.2018.09.220DOI Listing
February 2019

[Clinical analysis of endoscopic endonasal approach for removal of sellar tumors].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Nov;32(22):1735-1739

Department of Radiology, Tianjin Huanhu Hospita.

To investigate the safety and efficacy of endoscopic endonasal approach for removal of sellar tumors. The clinical data of 18 patients with sellar tumors undergoing endoscopic endonasal surgery were analyzed retrospectively. This series consisted of ten pituitary adenomas, five craniopharyngiomas, three meningiomas. Read More

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http://dx.doi.org/10.13201/j.issn.1001-1781.2018.22.013DOI Listing
November 2018
2 Reads

Analyzation of Endonasal Endoscopic Transsphenoidal (EET) surgery pathway and workspace for path guiding robot design.

Asian J Surg 2019 Jan 29. Epub 2019 Jan 29.

Center for Biomedical and Robotics Technology (BART LAB), Department of Biomedical Engineering, Faculty of Engineering, Mahidol University, Salaya, Thailand. Electronic address:

Background: Endoscopic Endonasal Transsphenoidal Surgery (EETS) is the standard method to treat pituitary adenoma, tumor in the pituitary gland which would affect human beings in terms of hormonal malfunction and other symptoms. This procedure provides extra minimal invasive access in severe cases. The objective of this paper is to design and develop a prototype of EET robot with navigation guidance system based on the study of EET workspace and pathway to determine a safe space for surgical tool insertion. Read More

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http://dx.doi.org/10.1016/j.asjsur.2018.12.016DOI Listing
January 2019

Transsphenoidal Removal of Retroclival Chondroma with Pituitary Transposition Manifesting as Repeated Subarachnoid Hemorrhage: A Case Report.

J Neurol Surg A Cent Eur Neurosurg 2019 Feb 1. Epub 2019 Feb 1.

Department of Neurosurgery, Tohoku University Graduate School of Medicine, Sendai, Japan.

Background:  Intracranial chondromas are extremely rare and represent only 0.2% of all intracranial primary neoplasms. The histologic appearance lacks nuclear atypism and mitoses, and it usually shows low growth potential, although these benign features do not necessarily imply a good prognosis. Read More

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http://dx.doi.org/10.1055/s-0038-1677452DOI Listing
February 2019
1 Read

Metabolomics-A Promising Approach to Pituitary Adenomas.

Front Endocrinol (Lausanne) 2018 17;9:814. Epub 2019 Jan 17.

6th Department of Medical Sciences, Department of Endocrinology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.

Metabolomics-the novel science that evaluates the multitude of low-molecular-weight metabolites in a biological system, provides new data on pathogenic mechanisms of diseases, including endocrine tumors. Although development of metabolomic profiling in pituitary disorders is at an early stage, it seems to be a promising approach in the near future in identifying specific disease biomarkers and understanding cellular signaling networks. To review the metabolomic profile and the contributions of metabolomics in pituitary adenomas (PA). Read More

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http://dx.doi.org/10.3389/fendo.2018.00814DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345099PMC
January 2019
6 Reads

A Case of Primary Sellar Paraganglioma: Immunohistochemistry Resource and Review.

World Neurosurg 2019 Jan 28. Epub 2019 Jan 28.

Section of Neurosurgery, The University of Chicago Medicine and Biological Sciences, 5841 S. Maryland Avenue, Chicago, IL. Electronic address:

Background: The differential diagnosis of sellar masses includes adenoma, meningioma, craniopharyngioma, and metastasis. Seldom is primary paraganglioma considered. Here we present a case of this unique pathology, review the relevant literature and compile a compendium of immunohistochemical characteristics for use as a resource. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.01.094DOI Listing
January 2019
1 Read

Visual Outcome of Patients with Pituitary Adenomas Following Surgery and Its Contributory Factors at a Tertiary Hospital in Ghana.

Ethiop J Health Sci 2019 Jan;29(1):895-902

Department of Community Dentistry, School of Medicine and Dentistry, College of Health Sciences, University of Ghana, Accra, Ghana.

Background: Craniotomy and transphenoidal microsurgery are surgical options for treatment of pituitary adenoma at Korle Bu Teaching Hospital(KBTH). Despite major advances and reported success rates of transphenoidal resection globally, paucity of local data regarding visual outcome of either procedure exists. We evaluated the visual outcome of patient with pituitary adenoma following surgery in a tertiary hospital in Ghana. Read More

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http://dx.doi.org/10.4314/ejhs.v29i1.11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341437PMC
January 2019

The efficacy of microperimetry and contrast sensitivity test in the diagnosis of optic chiasm compression due to pituitary adenomas.

Endokrynol Pol 2019 Jan 30. Epub 2019 Jan 30.

Department of Ophthalmology, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland.

Introduction: The aim of the study was to determine which microperimetry and contrast sensitivity test parameters would prove the most valuable during diagnosing optic chiasm compression due to pituitary adenomas.

Methods: Control group comprised healthy individuals (Group 1). Patients with pituitary macroadenoma were divided into two groups: Group 2 - absent optic chiasm compression, Group 3 - present optic chiasm compression detected on contrast-enhanced Magnetic Resonance Imaging (MRI). Read More

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http://dx.doi.org/10.5603/EP.a2019.0003DOI Listing
January 2019

An update on clinical care for pregnant women with acromegaly.

Expert Rev Endocrinol Metab 2019 Jan 17:1-12. Epub 2019 Jan 17.

d Service d'Endocrinologie et des Maladies Métaboliques , Centre Hospitalier Universitaire de Toulouse, Hôpital Larrey , Toulouse , France.

Introduction: As pregnancy is rare in women with acromegaly, only case reports and few series have been published. Areas covered: All case reports and publications dealing with pregnancy in patients with acromegaly were collated. Information concerning the effects of acromegaly on pregnancy outcomes, the impact of pregnancy on GH/IGF-I measurements, acromegaly comorbidity and pituitary adenoma size, the effects of treatment of acromegaly on fetus outcomes were retrieved and analyzed. Read More

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https://www.tandfonline.com/doi/full/10.1080/17446651.2019.1
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http://dx.doi.org/10.1080/17446651.2019.1571909DOI Listing
January 2019
9 Reads

Deferred Radiotherapy After Debulking of Non-functioning Pituitary Macroadenomas: Clinical Outcomes.

Front Oncol 2018 10;8:660. Epub 2019 Jan 10.

Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, United States.

To describe the outcome for a cohort of patients with non-functioning pituitary macroadenomas (NFPMA), managed by debulking surgery with radiation therapy delayed until progression. Two hundred and sixty-seven patients were treated surgically for pituitary tumors at our institution between 1997 and 2005. One hundred and twenty-six patients met the inclusion criteria of NFPMA. Read More

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http://dx.doi.org/10.3389/fonc.2018.00660DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335347PMC
January 2019
1 Read

Next-generation sequencing identifies novel mitochondrial variants in pituitary adenomas.

J Endocrinol Invest 2019 Jan 25. Epub 2019 Jan 25.

"Lendulet" Hereditary Endocrine Tumours Research Group, Hungarian Academy of Sciences and Semmelweis University, 46 Szentkiralyi Street, Budapest, H-1088, Hungary.

Purpose: Disrupted mitochondrial functions and genetic variants of mitochondrial DNA (mtDNA) have been observed in different human neoplasms. Next-generation sequencing (NGS) can be used to detect even low heteroplasmy-level mtDNA variants. We aimed to investigate the mitochondrial genome in pituitary adenomas by NGS. Read More

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http://link.springer.com/10.1007/s40618-019-1005-6
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http://dx.doi.org/10.1007/s40618-019-1005-6DOI Listing
January 2019
3 Reads

Hypertrophic cervical spine pachymeningitis due to sarcoidosis: a case report.

Hosp Pract (1995) 2019 Feb 6:1-5. Epub 2019 Feb 6.

d Pathology , Lehigh Valley Health Network , Allentown , PA , USA.

Hypertrophic pachymeningitis (HP) is a chronic, progressive diffuse inflammatory condition that leads to thickening of the dura mater and can be idiopathic or associated with sarcoidosis among other disorders. In this case report, we present a rare case of cervical spine HP in a 29-year-old woman in the post-partum period, who had a history of pituitary adenoma and juvenile rheumatoid arthritis. Magnetic resonance imaging (MRI) of the spine revealed a soft tissue mass and moderate cord compression. Read More

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https://www.tandfonline.com/doi/full/10.1080/21548331.2019.1
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http://dx.doi.org/10.1080/21548331.2019.1575645DOI Listing
February 2019
8 Reads

CORRIGENDUM FOR "High Prevalence of Radiological Vertebral Fractures in Patients With TSH-Secreting Pituitary Adenoma".

Authors:

J Endocr Soc 2019 Feb 28;3(2):358. Epub 2018 Dec 28.

[This corrects the article DOI: 10.1210/js.2018-00091. Read More

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http://dx.doi.org/10.1210/js.2018-00416DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339455PMC
February 2019

Expressions of Matrix Metalloproteinases-9 and Tissue Inhibitor of Metalloproteinase-1 in Pituitary Adenomas and Their Relationships with Prognosis.

Cancer Biother Radiopharm 2019 Feb 24;34(1):1-6. Epub 2019 Jan 24.

1 Department of Neurosurgery, Harrison International Peace Hospital affiliated to Hebei Medical University, Hengshui, China.

Objective: To investigate the expression levels of matrix metalloproteinases-9 (MMP-9) and tissue inhibitor of metalloproteinase-1 (TIMP-1) in pituitary adenomas (PAs), and to analyze the relationship of the expressions of the two with the prognosis of patients.

Methods: A total of 108 patients with PAs diagnosed in our hospital from May 2010 to May 2012 were selected and divided into the invasive PA (IPA) group (n = 58) and the non-IPA group (n = 50) according to the invasiveness of PAs. Hematoxylin and eosin (H&E) staining was used to observe the pathological state of patients. Read More

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https://www.liebertpub.com/doi/10.1089/cbr.2018.2589
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http://dx.doi.org/10.1089/cbr.2018.2589DOI Listing
February 2019
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Role of Vasopressin Receptor 2 and 3 in ACTH-Secreting Tumors and their Potential Therapeutic Implications.

Exp Clin Endocrinol Diabetes 2019 Jan 22. Epub 2019 Jan 22.

Department of Endocrinology and Metabolism, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.

Purpose: We investigated the expression of vasopressin receptor 2 and 3 on corticotrophin tumor cells, their role in regulating ACTH secretion, and their potential therapeutic implications.

Methods: We retrospectively assessed 52 hospitalized patients with pathologically confirmed ACTH-secreting tumors. The expression of vasopressin receptor 2 and 3 was explored via qualitative and quantitative immunohistochemistry analyses. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/a-0808-4227
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http://dx.doi.org/10.1055/a-0808-4227DOI Listing
January 2019
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Identification of TGFβ-induced proteins in non-endocrine mouse pituitary cell line TtT/GF by SILAC-assisted quantitative mass spectrometry.

Cell Tissue Res 2019 Jan 21. Epub 2019 Jan 21.

Institute for Endocrinology, Meiji University, Kawasaki, Kanagawa, Japan.

TtT/GF is a mouse cell line derived from a thyrotropic pituitary tumor and has been used as a model of folliculostellate cells. Our previous microarray data indicate that TtT/GF possesses some properties of endothelial cells, pericytes and stem/progenitor cells, along with folliculostellate cells, suggesting its plasticity. We also found that transforming growth factor beta (TGFβ) alters cell motility, increases pericyte marker transcripts and attenuates endothelial cell and stem/progenitor cell markers in TtT/GF cells. Read More

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http://link.springer.com/10.1007/s00441-018-02989-2
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http://dx.doi.org/10.1007/s00441-018-02989-2DOI Listing
January 2019
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An uncommon cause of acute abdomen in an acromegalic patient: colonic volvulus.

Ann Ital Chir 2018 ;89:572-576

Acromegaly is a chronic endocrine disease, typically caused by a pituitary adenoma leading to increased circulating GH levels and increased IGF-I secretion by peripheral tissues. Gastrointestinal diseases related acromegaly such as colon cancers, adenomatous polyps, and dolichocolon are much less known. We aimed to present a case of complete colonic volvulus in a patient with acromegaly. Read More

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January 2018
3 Reads

Pattern of intracranial tumours in a tertiary hospital in Ghana.

Ghana Med J 2018 Jun;52(2):79-83

Neurosurgery Unit, Department of Surgery, Korle Bu Teaching Hospital, P.M.B KB77, Accra. Ghana.

Objective: This study seeks to describe the pattern of intracranial tumours in Korle Bu Teaching Hospital (KBTH) based on patient demographics, clinical presentation, spatial distribution of tumour and histological findings.

Method: The study design is retrospective and descriptive. Data was obtained from the clinical records of patients with intracranial tumours treated in our neurosurgery unit between January 2010 to December 2015, and histology reports obtained from the histopathology unit. Read More

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http://dx.doi.org/10.4314/gmj.v52i2.3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326539PMC
June 2018
2 Reads

Long-Term Follow-Up Studies of Gamma Knife Radiosurgery for Postsurgical Nonfunctioning Pituitary Adenomas.

World Neurosurg 2019 Jan 17. Epub 2019 Jan 17.

Capital Medical University, Beijing Neurosurgical Institute, Beijing Tiantan Hospital, Beijing Institute for Brain Disorders Brain Tumor Center, China National Clinical Research Center for Neurological Diseases, Key Laboratory of Central Nervous System Injury Research, Beijing, China. Electronic address:

Objective: The aim of this study was to evaluate the long-term clinical outcomes of Gamma Knife radiosurgery (GKRS) for residual and recurrent nonfunctioning pituitary adenomas (NFPAs) after surgery and the role of GKRS in the management of NFPAs.

Methods: Between January 2000 and December 2010, 204 patients with residual or recurrent NFPAs undergoing GKRS were enrolled in this study according to the inclusion criteria. The median age of the patients was 48 years (mean, 48 years; range, 14-79 years). Read More

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http://dx.doi.org/10.1016/j.wneu.2019.01.009DOI Listing
January 2019

Quantitative assessment of secondary white matter injury in the visual pathway by pituitary adenomas: a multimodal study at 7-Tesla MRI.

J Neurosurg 2019 Jan 18:1-10. Epub 2019 Jan 18.

1Translational and Molecular Imaging Institute and.

OBJECTIVEThe objective of this study was to investigate microstructural damage caused by pituitary macroadenomas by performing probabilistic tractography of the optic tracts and radiations using 7-T diffusion-weighted MRI (DWI). These imaging findings were correlated with neuro-ophthalmological results to assess the utility of ultra-high-field MRI for objective evaluation of damage to the anterior and posterior visual pathways.METHODSProbabilistic tractography employing 7-T DWI was used to reconstruct the optic tracts and radiations in 18 patients with adenomas and in 16 healthy volunteers. Read More

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http://dx.doi.org/10.3171/2018.9.JNS182022DOI Listing
January 2019
2 Reads