1,246 results match your criteria Pituitary [Journal]


The role of autoimmunity in pituitary dysfunction due to traumatic brain injury.

Pituitary 2019 Mar 7. Epub 2019 Mar 7.

Department of Advanced Medical and Surgical Sciences, University of Campania "Luigi Vanvitelli", Naples, Italy.

Purpose: Traumatic brain injury (TBI) is one of the most common causes of mortality and long-term disability and it is associated with an increased prevalence of neuroendocrine dysfunctions. Post-traumatic hypopituitarism (PTHP) results in major physical, psychological and social consequences leading to impaired quality of life. PTHP can occur at any time after traumatic event, evolving through various ways and degrees of deficit, requiring appropriate screening for early detection and treatment. Read More

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http://link.springer.com/10.1007/s11102-019-00953-z
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http://dx.doi.org/10.1007/s11102-019-00953-zDOI Listing
March 2019
2 Reads

Radiological and endocrinological evaluations with grading of hypothalamic perifocal edema caused by craniopharyngiomas.

Pituitary 2019 Apr;22(2):146-155

Department of Neurosurgery, Graduate School of Medical Science, Kanazawa University, 13-1, Takara-machi, Kanazawa, Ishikawa, 920-8641, Japan.

Introduction: Hypophysial and hypothalamic dysfunction caused by craniopharyngioma is a serious problem despite the progress of surgical approaches and techniques. Perifocal edema induced by craniopharyngioma could be speculated as a potential factor resulting in pre- and post-operative hypophysial and hypothalamic dysfunction, as well as, their anatomical involvement.

Methods: Medical records of 54 patients with craniopharyngioma were retrospectively reviewed. Read More

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http://dx.doi.org/10.1007/s11102-019-00945-zDOI Listing
April 2019
1 Read

Pretreatment with somatostatin analogs does not affect the anesthesiologic management of patients with acromegaly.

Pituitary 2019 Apr;22(2):187-194

Pituitary Unit of the Division of Neurosurgery, IRCCS San Raffaele, Vita-Salute University, Via Olgettina 60, 20132, Milan, Italy.

Purpose: Acromegaly may be associated with an increased risk of complex intraoperative management and anesthetic complications. No study addressed whether pretreatment with somatostatin receptor ligands (SRLs) affects anesthesiologic management.

Methods: We studied 211 consecutive acromegalic patients who had a recorded intraoperative computerized anesthetic record (ICAR) available for analysis. Read More

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http://dx.doi.org/10.1007/s11102-019-00952-0DOI Listing
April 2019
1 Read

The history of pituitary dysfunction after traumatic brain injury.

Pituitary 2019 Mar 2. Epub 2019 Mar 2.

Department of Clinical and Experimental Medicine, University of Messina, 98125, Messina, Italy.

Purpose: To estimate the total number of articles on traumatic brain injury (TBI)-related hypopituitarism and patients (including children and adolescents) with such disorder that were published until now, particularly after the author's review published on April 2000.

Methods: Review of the literature retrievable on PubMed.

Results: TBI-related hypopituitarism accounts for 7. Read More

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http://dx.doi.org/10.1007/s11102-019-00949-9DOI Listing

Use of a wrist-mounted device for continuous outpatient physiologic monitoring after transsphenoidal surgery: a pilot study.

Pituitary 2019 Apr;22(2):156-162

Department of Neurosurgery, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ, USA.

Purpose: Patients who undergo transsphenoidal surgery can experience hormonal, electrolyte, and fluid disturbances in the postoperative period leading to outpatient readmissions for medical management. Our goal was to determine whether use of a wrist-mounted physiologic tracking device is feasible in this setting and whether changes or trends in these parameters after discharge can help predict aberrant physiology in these patients.

Methods: Wrist-mounted physiologic tracking devices that transmit data via Bluetooth to a mobile device were used to monitor patients. Read More

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http://dx.doi.org/10.1007/s11102-019-00946-yDOI Listing
April 2019
1 Read

Filamin A and DRD2 expression in corticotrophinomas.

Pituitary 2019 Apr;22(2):163-169

Neuroendocrine Unit, Division of Endocrinology and Metabolism, Hospital das Clínicas & Laboratory of Cellular and Molecular Endocrinology LIM-25, University of Sao Paulo Medical School, São Paulo, SP, Brazil.

Purpose: Filamin A (FLNA) expression is related to dopamine receptor type 2 (DRD2) expression in prolactinomas. Nevertheless, in corticotrophinomas, there are few studies about DRD2 expression and no data on FLNA. Therefore, we evaluated FLNA and DRD2 expression in corticotrophinomas and their association with tumor characteristics. Read More

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http://dx.doi.org/10.1007/s11102-019-00947-xDOI Listing

The incidence of Cushing's disease: a nationwide Swedish study.

Pituitary 2019 Apr;22(2):179-186

Department of Internal Medicine and Clinical Nutrition, Institute of Medicine at Sahlgrenska Academy, University of Gothenburg, and The Department of Endocrinology, Sahlgrenska University Hospital, Gröna Stråket 8, 413 45, Gothenburg, Sweden.

Background: Studies on the incidence of Cushing's disease (CD) are few and usually limited by a small number of patients. The aim of this study was to assess the annual incidence in a nationwide cohort of patients with presumed CD in Sweden.

Methods: Patients registered with a diagnostic code for Cushing's syndrome (CS) or CD, between 1987 and 2013 were identified in the Swedish National Patient Registry. Read More

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http://dx.doi.org/10.1007/s11102-019-00951-1DOI Listing

Increased androgen secretion in patients with prolactinomas: the impact of altered HPA function.

Pituitary 2019 Apr;22(2):170-178

Division of Clinical and Molecular Endocrinology, UH Cleveland Medical Center and Case Western University, 11100 Euclid Avenue, Cleveland, OH, 44106, USA.

Background And Objectives: Earlier studies suggested that hyperprolactinemia was associated with elevated serum DHEA-S levels. The importance of DHEA-S measurements in the diagnosis of adrenal insufficiency prompted us to assess adrenal androgen levels in hyperprolactinemic subjects with normal or impaired function.

Methods: Prospective study including 122 medically treated and 26 surgically patients with prolactinomas. Read More

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http://dx.doi.org/10.1007/s11102-019-00948-wDOI Listing
April 2019
2 Reads

AcroVoice: the controversial values in reflecting acromegaly disease activity.

Pituitary 2019 Feb 22. Epub 2019 Feb 22.

Department of Neurosurgery, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, No. 1 Shuaifuyuan, Dongcheng District, Beijing, 100730, People's Republic of China.

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http://dx.doi.org/10.1007/s11102-019-00950-2DOI Listing
February 2019
1 Read

Treatment adherence to pegvisomant in patients with acromegaly in Spain: PEGASO study.

Pituitary 2019 Apr;22(2):137-145

Pfizer S.L.U, Avda. Europa, 20B. Parque Empresarial La Moraleja, 28108, Alcobendas, Madrid, Spain.

Purpose: The burden of chronic daily subcutaneous administration of pegvisomant on adherence has not been previously studied. This study was aimed to determine the adherence to pegvisomant treatment in acromegaly patients in the real-world clinical practice setting in Spain.

Methods: Multicenter, observational, descriptive, cross-sectional study in patients with acromegaly treated with pegvisomant for at least 12 months. Read More

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http://link.springer.com/10.1007/s11102-019-00943-1
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http://dx.doi.org/10.1007/s11102-019-00943-1DOI Listing
April 2019
4 Reads

Traumatic brain injury induced neuroendocrine changes: acute hormonal changes of anterior pituitary function.

Pituitary 2019 Feb 12. Epub 2019 Feb 12.

Department of Endocrinology and Diabetes, Evangelismos Hospital, Athens, Greece.

Purpose: It is estimated that approximately 69 million individuals worldwide will sustain a TBI each year, which accounts for substantial morbidity and mortality in both children and adults. TBI may lead to significant neuroendocrine changes, if the delicate pituitary is ruptured. In this review, we focus on the anterior pituitary hormonal changes in the acute post-TBI period and we present the evidence supporting the need for screening of anterior pituitary function in the early post-TBI time along with current suggestions regarding the endocrine assessment and management of these patients. Read More

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http://link.springer.com/10.1007/s11102-019-00944-0
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http://dx.doi.org/10.1007/s11102-019-00944-0DOI Listing
February 2019
6 Reads

A clinical and pathophysiological approach to traumatic brain injury-induced pituitary dysfunction.

Pituitary 2019 Feb 7. Epub 2019 Feb 7.

Department of Endocrinology, Yeditepe University, Faculty of Medicine, Kosuyolu Hospital, 34718, Istanbul, Turkey.

Purpose: This review aimed to evaluate the data underlying the pathophysiology of TBI-induced hypothalamo-pituitary dysfunction.

Methods: Recent literature about the pathophysiology of TBI-induced hypothalamo-pituitary dysfunction reviewed.

Results: Traumatic brain injury (TBI) is a worldwide epidemic that frequently leads to death; TBI survivors tend to sustain cognitive, behavioral, psychological, social, and physical disabilities in the long term. Read More

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http://link.springer.com/10.1007/s11102-019-00941-3
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http://dx.doi.org/10.1007/s11102-019-00941-3DOI Listing
February 2019
2 Reads
2.222 Impact Factor

Clinical score system in the treatment of Cushing's disease: failure to identify discriminative variables from the German Cushing's Registry.

Pituitary 2019 Apr;22(2):129-136

Neuroendocrinology Research Group, Max Planck Institute of Psychiatry Munich, Kraepelinstr. 2-10, 80804, Munich, Germany.

Purpose: To develop a multidimensional and integrated clinical scoring instrument, that encompasses, summarizes and weights appropriately the desired clinical benefits of a treatment for Cushing's disease (CD).

Methods: A panel of 42 variables potentially relevant to the clinical course of CD was predefined by endocrinology experts taking into account relevant literature. Variables as well as biochemical disease activity assessed as urinary free cortisol (UFC) levels were evaluated at baseline and at least after 12 months in patients treated between 2012 and 2016 in two Munich-based academic centres of the German Cushing's Registry. Read More

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http://dx.doi.org/10.1007/s11102-019-00942-2DOI Listing

Response to letter to the editor from Professor Jean-François Bonneville.

Pituitary 2019 Feb;22(1):103

Departments of Medicine and Neurological Surgery, Northwest Pituitary Center, Oregon Health & Science University, Mail Code: CH8N, 3303 SW Bond Ave., Portland, OR, 97239, USA.

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http://dx.doi.org/10.1007/s11102-018-00934-8DOI Listing
February 2019

Long term MRI surveillance of pituitary macroadenomas: gadolinium is not obligatory.

Pituitary 2019 Feb;22(1):100-102

Departments of Medical Imaging and Endocrinology, Centre Hospitalier Universitaire de Liege, Liège, Belgium.

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http://dx.doi.org/10.1007/s11102-018-00931-xDOI Listing
February 2019
1 Read

Pituitary incidentalomas in paediatric age are different from those described in adulthood.

Pituitary 2019 Apr;22(2):124-128

Faculty of Medicine of University of Porto, Porto, Portugal.

Purpose: Guidelines on pituitary incidentalomas evaluation and management are limited to adults since there are no data on this matter in the paediatric population. We aim to analyse the morphologic characteristics, hormonal profile and follow-up of these lesions in children.

Methods: We have searched for pituitary incidentalomas in the neuroimaging reports and electronic medical records of the Paediatric Endocrinology Clinic of our centre. Read More

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http://dx.doi.org/10.1007/s11102-019-00940-4DOI Listing
April 2019
3 Reads

The frequency and the diagnosis of pituitary dysfunction after traumatic brain injury.

Pituitary 2019 Jan 25. Epub 2019 Jan 25.

Academic Department of Endocrinology, Beaumont Hospital and the RCSI Medical School, Beaumont Road, Dublin 9, Ireland.

Purpose: Clinical research studies over the last 15 years have reported a significant burden of hypopituitarism in survivors of traumatic brain injury (TBI). However, debate still exists about the true prevalence of hypopituitarism after head injury.

Methods: We have reviewed the literature describing the frequency of post-traumatic hypopituitarism and discuss the factors which may explain the variable frequency of the reported deficits in clinical studies including research methodology and the natural history of the disease. Read More

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http://dx.doi.org/10.1007/s11102-019-00938-yDOI Listing
January 2019
2 Reads

Oxytocin alterations and neurocognitive domains in patients with hypopituitarism.

Pituitary 2019 Apr;22(2):105-112

Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Illinois at Chicago, 1819 West Polk Street, Chicago, IL, 60612, USA.

Purpose: Oxytocin is a hypothalamus derived, posterior pituitary stored nonapeptide which has gained recent interest as an important neuropsychiatric and metabolic hormone beyond its classic role in lactation and parturition. Hypopituitarism is a heterogenous disorder of derangement in one or more anterior or posterior pituitary hormones. Diagnosis of deficiency and hormone replacement exists to address all relevant axes except for oxytocin. Read More

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http://link.springer.com/10.1007/s11102-019-00936-0
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http://dx.doi.org/10.1007/s11102-019-00936-0DOI Listing
April 2019
11 Reads

Pituitary adenomas in patients with multiple endocrine neoplasia type 1: a single-center experience in China.

Pituitary 2019 Apr;22(2):113-123

Department of Endocrinology, Peking Union Medical College Hospital, Beijing, 100730, China.

Purpose: To explore the clinical characteristics of pituitary adenomas in patients with MEN1 and to summarize treatment strategies for MEN1 in a Chinese population.

Methods: We retrospectively analyzed 54 MEN1 patients with pituitary adenomas diagnosed at Peking Union Medical College Hospital from March 2003 to January 2017. Clinical data, laboratory testing results, treatments of involved glands and treatment responses were collected and analyzed. Read More

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http://link.springer.com/10.1007/s11102-019-00939-x
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http://dx.doi.org/10.1007/s11102-019-00939-xDOI Listing
April 2019
16 Reads
2.222 Impact Factor

Pituitary dysfunction due to sports-related traumatic brain injury.

Pituitary 2019 Jan 14. Epub 2019 Jan 14.

Memorial Kayseri Hospital, Endocrinology Clinic, Kayseri, Turkey.

Purpose: After traumatic brain injury was accepted as an important etiologic factor of pituitary dysfunction (PD), awareness of risk of developing PD following sports-related traumatic brain injury (SR-TBI) has also increased. However there are not many studies investigating PD following SR-TBIs yet. We aimed to summarize the data reported so far and to discuss screening algorithms and treatment strategies. Read More

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http://link.springer.com/10.1007/s11102-019-00937-z
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http://dx.doi.org/10.1007/s11102-019-00937-zDOI Listing
January 2019
9 Reads

Neuroendocrine changes after aneurysmal subarachnoid haemorrhage.

Pituitary 2019 Jan 14. Epub 2019 Jan 14.

Department of Endocrinology and Metabolism, Yeditepe University Medical School, Istanbul, Turkey.

Introduction: The prevalence of pituitary dysfunction is high following aneurysmal subarachnoid hemorrhage (aSAH) and when occurs it may contribute to residual symptoms of aSAH such as decreased cognition and quality of life. Hypopituitarism following aSAH may have non-specific, subtle symptoms and potentially serious consequences if remained undiagnosed.

Methods: We reviewed the literature on epidemiology, pathophysiology, diagnostic methods and management of neuroendocrine changes after aSAH as well as on the impact of pituitary dysfunction on outcome of the patient. Read More

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http://link.springer.com/10.1007/s11102-018-00932-w
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http://dx.doi.org/10.1007/s11102-018-00932-wDOI Listing
January 2019
6 Reads

Paul Kelly, PhD (1943-2018).

Pituitary 2019 Feb;22(1):1-3

University of Manitoba, Winnipeg, MB, Canada.

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http://dx.doi.org/10.1007/s11102-018-0929-8DOI Listing
February 2019
4 Reads

AcroVoice: eliciting the patients' perspective on acromegaly disease activity.

Pituitary 2019 Feb;22(1):62-69

Pfizer Canada Inc, Rare Disease Medical Affairs, Kirkland, QC, Canada.

Purpose: To determine how patients define acromegaly disease activity and treatment success and to quantify from the patients' perspective the relative importance of each disease parameter included in the ACRODAT®.

Methods: One hundred acromegaly patients on medical therapy (mean age = 47.1 years; SD = 11. Read More

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http://dx.doi.org/10.1007/s11102-018-00933-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373299PMC
February 2019
2 Reads

Evaluation of expression of somatostatin receptor 1, 2, 3, 5 and dopamine D2 receptor in spindle cell oncocytomas of posterior pituitary.

Pituitary 2019 Feb;22(1):70-78

4th Department of Internal Medicine, University Hospital and Faculty of Medicine Hradec Kralove, Charles University, Sokolska 581, 500 05, Hradec Kralove, Czech Republic.

Purpose: Spindle cell oncocytomas (SCOs) are very rare tumors of the posterior pituitary with potential for locally aggressive behaviour. Their treatment includes surgery and possibly radiotherapy, however other options are lacking. Somatostatin receptors (SSTs) are a possible therapeutic target for somatostatin analogues and their expression has been demonstrated recently in closely related pituicytomas, but there are no data about their presence in SCOs. Read More

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http://dx.doi.org/10.1007/s11102-018-00935-7DOI Listing
February 2019
2 Reads

IgG4-related hypophysitis in patients with autoimmune pancreatitis.

Pituitary 2019 Feb;22(1):54-61

Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe, Hyogo, 650-0017, Japan.

Purpose: IgG4-related disease involves various organs including the pituitary and pancreas. The prevalence of IgG4-related hypophysitis is relatively rare compared with IgG4-related pancreatitis (autoimmune pancreatitis). Although several cases demonstrating both autoimmune pancreatitis and hypophysitis have been reported, the prevalence of IgG4-related hypophysitis in patients with autoimmune pancreatitis remains unknown. Read More

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http://dx.doi.org/10.1007/s11102-018-00930-yDOI Listing
February 2019
1 Read

A small 3D-printing model of macroadenomas for endoscopic endonasal surgery.

Pituitary 2019 Feb;22(1):46-53

Department of Neurosurgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, Hubei, China.

Purpose: This paper examines the application of 3D printing technology in the endoscopic endonasal approach for the treatment of macroadenomas.

Methods: We have retrospectively analysed 20 patients who diagnosed with macroadenoma underwent endoscopic transsphenoidal surgery in Wuhan Union hospital from January 2017 to May 2017. Among the 20 patients, 10 patients received the service of 3D printing technology preoperatively. Read More

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http://link.springer.com/10.1007/s11102-018-0927-x
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http://dx.doi.org/10.1007/s11102-018-0927-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373287PMC
February 2019
14 Reads

A plea for the T2W MR sequence for pituitary imaging.

Pituitary 2019 Apr;22(2):195-197

Departments of Endocrinology and Medical Imaging, Centre Hospitalier Universitaire de Liège, Liège, Belgium.

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http://link.springer.com/10.1007/s11102-018-0928-9
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http://dx.doi.org/10.1007/s11102-018-0928-9DOI Listing
April 2019
3 Reads

A neurosurgical approach to traumatic brain injury and post-traumatic hypopituitarism.

Pituitary 2018 Nov 27. Epub 2018 Nov 27.

Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Cambridge Biomedical Campus, Box 167, CB2 0QQ, Cambridge, UK.

Purpose: Traumatic brain injury (TBI) is a common cause of mortality and major disability worldwide. The initial management often depends on the severity of the injury. Pituitary dysfunction can develop as a sequela of TBI, and can have long-term, debilitating impact on the patients. Read More

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http://dx.doi.org/10.1007/s11102-018-0925-zDOI Listing
November 2018
2 Reads

Cell specific interaction of pasireotide: review of preclinical studies in somatotroph and corticotroph pituitary cells.

Pituitary 2019 Feb;22(1):89-99

Endocrinology Unit, Department of Internal Medicine, Policlinico San Martino, 16132, Genoa, Italy.

Background: Pasireotide is a second-generation somatostatin (SRIF) receptor ligand (SRL), approved for medical treatment of acromegaly and Cushing's disease (CD). The molecule is a stable cyclohexapeptide synthetized based on SRIF structure. Differently from first-generation SRLs (e. Read More

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http://dx.doi.org/10.1007/s11102-018-0926-yDOI Listing
February 2019
3 Reads

Physicians' awareness of gadolinium retention and MRI timing practices in the longitudinal management of pituitary tumors: a "Pituitary Society" survey.

Pituitary 2019 Feb;22(1):37-45

Departments of Medicine and Neurological Surgery, Northwest Pituitary Center, Oregon Health & Science University, Mail Code: CH8N, 3303 SW Bond Ave., Portland, OR, 97239, USA.

Purpose: In view of mounting attention related to possible brain retention of gadolinium-based contrast agents (GBCAs) in patients with normal renal function, our purpose was to detail results from a survey of pituitary experts to assess: 1) the timing interval and frequency of pituitary magnetic resonance imaging (MRI) following surgical and/or medical and/or radiation therapy of pituitary tumors, 2) awareness of the types of GBCAs used and their possible safety issues.

Methods: The Pituitary Society Education Committee composed a survey with 12 multiple choice questions, 8 of which specifically addressed the time interval and frequency of MRI in the longitudinal management of pituitary tumors. The survey was distributed at two meetings; the International Pituitary Neurosurgeons Society conference in San Diego, CA, on February 18th, 2018, and the Pituitary Society Membership and Career Development Forum, Chicago, IL on March 18th, 2018. Read More

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http://dx.doi.org/10.1007/s11102-018-0924-0DOI Listing
February 2019
3 Reads

Evaluation of the natural course of thyroid nodules in patients with acromegaly.

Pituitary 2019 Feb;22(1):29-36

Division of Endocrinology and Metabolism, Department of Internal Medicine, Istanbul Faculty of Medicine, Istanbul University, Capa, 34090, Istanbul, Turkey.

Purpose: To investigate the nodular thyroid disease (NTD) and the natural course of thyroid nodules in patients with acromegaly.

Methods: 138 patients with acromegaly (73 F/65 M), whose initial thyroid ultrasonography performed in our university hospital, were included in this study. The frequencies of NTD, papillary thyroid cancer (PTC) and associated factors on nodule formation were investigated at initial assessment. Read More

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http://link.springer.com/10.1007/s11102-018-0923-1
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http://dx.doi.org/10.1007/s11102-018-0923-1DOI Listing
February 2019
59 Reads

Thyrotropin-secreting pituitary adenomas: a systematic review and meta-analysis of postoperative outcomes and management.

Pituitary 2019 Feb;22(1):79-88

Department of Neurosurgery, University Hospital of Lausanne, Lausanne, Switzerland.

Purpose: TSH-secreting pituitary adenomas are rare pituitary tumors. An efficient treatment is essential to limit the mortality and morbidity in untreated patients. The aim of this study is to summarize the evidence about the postoperative outcomes and management of this rare pathology. Read More

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http://link.springer.com/10.1007/s11102-018-0921-3
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http://dx.doi.org/10.1007/s11102-018-0921-3DOI Listing
February 2019
12 Reads
2.222 Impact Factor

Coagulative necrotic pituitary adenoma apoplexy: A retrospective study of 21 cases from a large pituitary center in China.

Pituitary 2019 Feb;22(1):13-28

Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 1 Shuaifuyuan, Dongcheng District, Beijing, 100730, People's Republic of China.

Purpose: Coagulative necrotic pituitary apoplexy (CNPA) is a clinical entity with unique intraoperative and histopathological manifestations. We aimed to improve the knowledge of this rare disease through the largest case series published to date.

Methods: A retrospective review of 21 CNPA patients was performed from among 5095 patients who underwent surgery for pituitary adenomas at a single institution between January 2009 and June 2017. Read More

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http://link.springer.com/10.1007/s11102-018-0922-2
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http://dx.doi.org/10.1007/s11102-018-0922-2DOI Listing
February 2019
14 Reads

Acknowledgment of Reviewers 2016 and 2017.

Authors:

Pituitary 2018 Dec;21(6):664-665

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http://dx.doi.org/10.1007/s11102-018-0919-xDOI Listing
December 2018
1 Read

Pre-surgical medical treatment, a major prognostic factor for long-term remission in acromegaly.

Pituitary 2018 Dec;21(6):615-623

Aix-Marseille Université, Institut National de la Santé et de la Recherche Médicale (INSERM), U1251, Marseille Medical Genetics (MMG), Marseille, France.

Purpose: To determine whether pre-surgical medical treatment (PSMT) using long-acting Somatostatin analogues in acromegaly may improve long-term surgical outcome and to determine decision making criteria.

Methods: This retrospective study included 110 consecutive patients newly diagnosed with acromegaly, who underwent surgery in a reference center (Marseille, France). The mean long-term follow-up period was 51. Read More

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http://link.springer.com/10.1007/s11102-018-0916-0
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http://dx.doi.org/10.1007/s11102-018-0916-0DOI Listing
December 2018
11 Reads

Decreased quality of life (QoL) in hypopituitary patients: involvement of glucocorticoid replacement and radiation therapy.

Pituitary 2018 Dec;21(6):624-630

Division of Metabolism, Endocrinology and Diabetes, Department of Medicine, University of Michigan, 24 Frank Lloyd Wright Drive, G-1500, Ann Arbor, MI, 48106, USA.

Purpose: Hypopituitary patients are assumed to have decreased QoL due to GHD. However, in placebo controlled trials, the effects of GH replacement are no different from placebo. Hydrocortisone dose > 20 mg/day and pituitary radiation are independently associated with poorer QoL. Read More

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http://dx.doi.org/10.1007/s11102-018-0918-yDOI Listing
December 2018
2 Reads

Posterior pituitary dysfunction following traumatic brain injury: review.

Pituitary 2018 Oct 17. Epub 2018 Oct 17.

Academic Department of Endocrinology, Beaumont Hospital/RCSI Medical School, Dublin, Ireland.

Neurohypophysial dysfunction is common in the first days following traumatic brain injury (TBI), manifesting as dysnatremia in approximately 1 in 4 patients. Both hyponatremia and hypernatremia can impair recovery from TBI and in the case of hypernatremia, there is a significant association with excess mortality. Hyponatremia secondary to syndrome of inappropriate antidiuretic hormone secretion (SIAD) is the commonest electrolyte disturbance following TBI. Read More

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http://link.springer.com/10.1007/s11102-018-0917-z
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http://dx.doi.org/10.1007/s11102-018-0917-zDOI Listing
October 2018
14 Reads

Delayed hypopituitarism following Russell's viper envenomation: a case series and literature review.

Pituitary 2019 Feb;22(1):4-12

Department of Endocrinology, Vydehi Institute of Medical Sciences and Research Centre, #82, EPIP Area, Whitefield, Bangalore, Karnataka, 560066, India.

Purpose: Hypopituitarism (HP) is an uncommon consequence of Russell's viper envenomation (RVE). Delayed hypopituitarism (DHP) presents months to years after recovering from snake bites (SB). The clinical presentation, manifestations, and outcomes of DHP following RVE have not been systematically studied. Read More

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http://dx.doi.org/10.1007/s11102-018-0915-1DOI Listing
February 2019
4 Reads

Work disability and its determinants in patients with pituitary tumor-related disease.

Pituitary 2018 Dec;21(6):593-604

Department of Neurosurgery, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands.

Introduction: Pituitary tumors may have a considerable impact on patients' functional status, including paid employment, yet research in this area is sparse.

Objective: To describe work disability and its determinants in patients treated for a pituitary tumor.

Methods: Cross-sectional study including patients treated for a pituitary tumor in the working age (18-65 years), who completed five validated questionnaires assessing work disability [Short Form-Health and Labour Questionnaire, Work Role Functioning Questionnaire 2. Read More

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http://dx.doi.org/10.1007/s11102-018-0913-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6244796PMC
December 2018
4 Reads

Single center study of 53 consecutive patients with pituitary stalk lesions.

Pituitary 2018 Dec;21(6):605-614

Neuroendocrine Department, Clinic for Endocrinology, Diabetes and Metabolic Diseases, Clinical Center of Serbia, Dr Subotica 13, Belgrade, 11000, Serbia.

Background: The etiological spectrum of pituitary stalk lesions (PSL) is wide and yet specific compared to the other diseases of the sellar and suprasellar region. Because of the pituitary stalk's (PS) critical location and role, biopsies of these lesions are rarely performed, and their underlying pathology is often a conundrum for clinicians. A pituitary MRI in association with a clinical context can facilitate their diagnosis. Read More

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http://dx.doi.org/10.1007/s11102-018-0914-2DOI Listing
December 2018
6 Reads

Correction to: Criteria for the definition of Pituitary Tumor Centers of Excellence (PTCOE): A Pituitary Society Statement.

Pituitary 2018 12;21(6):663

Division of Endocrinology, San Raffaele University Hospital, Milan, Italy.

The original version of this article unfortunately contained an affiliation error in 'Collaborators for The Pituitary Society, Expert Group on Pituitary Tumors' section. Dr. Misa Pfeifer is affiliated with Medical Faculty, University of Ljubljana, Slovenia and the correct email address to contact is misa. Read More

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http://link.springer.com/10.1007/s11102-018-0912-4
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http://dx.doi.org/10.1007/s11102-018-0912-4DOI Listing
December 2018
17 Reads

Preclinical markers of atherosclerosis in acromegaly: a systematic review and meta-analysis.

Pituitary 2018 Dec;21(6):653-662

Department of Medicine, DIMED, Internal Medicine 3, University of Padua, Via Giustiniani 2, 35128, Padova, Italy.

Objective: Multiple studies investigated preclinical markers of peripheral vascular damage in acromegaly (ACRO) reporting discordant results. The aim of this study was to run a meta-analysis to examine whether intima media thickness (IMT), flow mediated dilation (FMD) and arterial pulse wave velocity (PWV) are affected in acromegalic patients and to assess the impact of effective treatment of growth hormone excess on these outcomes.

Study Selection: Twenty-seven studies comparing ACRO vs control (CON) populations and active (ACT) vs inactive (INACT) ACRO were included in the meta-analysis. Read More

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http://link.springer.com/10.1007/s11102-018-0911-5
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http://dx.doi.org/10.1007/s11102-018-0911-5DOI Listing
December 2018
11 Reads

Pregnancy-associated Cushing's disease? An exploratory retrospective study.

Pituitary 2018 Dec;21(6):584-592

Pacific Neuroscience Institute, John Wayne Cancer Institute at Providence's Saint John's Health Center, 2125 Arizona Ave., Santa Monica, CA, 90404, USA.

Purpose: In most clinical series of Cushing's disease (CD), over 80% of patients are women, many of whom are of reproductive age. The year following pregnancy may be a common time to develop CD. We sought to establish the incidence of CD onset associated with pregnancy. Read More

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http://dx.doi.org/10.1007/s11102-018-0910-6DOI Listing
December 2018
4 Reads

BRAF V600E mutant papillary craniopharyngiomas: a single-institutional case series.

Pituitary 2018 Dec;21(6):571-583

Department of Neurosurgery, Weill Cornell Medical College, New York-Presbyterian Hospital, 525 East 68th St., Box #99, New York, NY, 10065, USA.

Purpose: To describe the clinical, radiographic and surgical outcomes in a cohort of patients with BRAF V600E mutant papillary craniopharyngiomas.

Methods: A retrospective review was performed to identify all patients with a histological diagnosis of CP operated upon at a single institution between 2005 and 2017. All cases with adequate material were sequenced to confirm the presence of BRAF V600E mutation. Read More

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http://dx.doi.org/10.1007/s11102-018-0909-zDOI Listing
December 2018
7 Reads
2.222 Impact Factor

Cost-effectiveness of acromegaly treatments: a systematic review.

Pituitary 2018 Dec;21(6):642-652

Graduate Program in Pharmaceutical Sciences, Universidade Federal do Paraná, Curitiba, Paraná, Brazil.

Purpose: Acromegaly is a rare disease that results in the enlargement of body extremities and in organomegaly. Treatments include surgery, drugs, and radiotherapy, which are all onerous. Therefore, well-conducted cost-analyses are crucial in the decision-making process. Read More

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http://dx.doi.org/10.1007/s11102-018-0908-0DOI Listing
December 2018
14 Reads

Medically induced CSF rhinorrhea following treatment of macroprolactinoma: case series and literature review.

Pituitary 2018 Dec;21(6):561-570

Saint Alphonsus Neuroscience Institute - Neurosurgery, Boise, ID, USA.

Purpose: Although several reports have addressed cerebrospinal fluid (CSF) rhinorrhea following dopamine agonist (DA) therapy of macroprolactinomas, further study is warranted for this relatively uncommon entity. Toward this aim, our retrospective series and review of literature further clarifies recommendations in treatment of this rare problem.

Methods: We retrospectively reviewed all macroprolactinoma cases in our hospital for a 15-year period. Read More

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http://dx.doi.org/10.1007/s11102-018-0907-1DOI Listing
December 2018
22 Reads
2.222 Impact Factor

Optical coherence tomography retinal ganglion cell complex analysis for the detection of early chiasmal compression.

Pituitary 2018 Oct;21(5):515-523

Department of Ophthalmology, Emory University School of Medicine, Atlanta, GA, USA.

Purpose: To report patients with sellar tumors and chiasmal compression with normal visual fields, who demonstrate damage to the retinal nerve fiber layer (RNFL) and ganglion cell complex (GCC) on optical coherence tomography (OCT).

Methods: Seven patients with sellar tumors causing mass effect on the optic chiasm without definite visual field defect, but abnormal GCC are described. GCC/RNFL analyses using Cirrus-OCT were classified into centiles based on the manufacturer's reference range. Read More

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http://dx.doi.org/10.1007/s11102-018-0906-2DOI Listing
October 2018
2 Reads

Management of pituicytomas: a multicenter series of eight cases.

Pituitary 2018 Oct;21(5):507-514

Department of Neurosurgery, Bâtiment Babinski, Groupe Hospitalier Pitié-Salpêtrière, APHP, 47-83 Boulevard de l'Hôpital, 75013, Paris, France.

Purpose: Pituicytomas and spindle cell oncocytomas (SCOs) are two rare neoplasms of the sellar and suprasellar region, known to be challenging as they are extremely vascular and almost always misdiagnosed, altering our surgical planning and the patients' outcomes. Also we argue that recent update concerning the pathology findings of these tumors should be more widely generalized to our practice.

Methods: This is a retrospective multicenter study, reporting the clinical manifestations, radiological characteristics, histopathological features, treatment strategies and long-term outcomes of patients who have been treated for a Pituicytoma at various institutions in Paris, France over the past 10 years. Read More

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http://dx.doi.org/10.1007/s11102-018-0905-3DOI Listing
October 2018
3 Reads

The experience with transsphenoidal surgery and its importance to outcomes.

Pituitary 2018 Oct;21(5):545-555

Department of Neurosurgery, University of Tuebingen, Hoppe-Seyler-Straße 3, 72076, Tuebingen, Germany.

Purpose: Surgical experience is considered paramount for excellent outcome of transsphenoidal surgery (TSS). However, objective data demonstrating the surgical success in relation to the experience of pituitary surgery units or individual experience of pituitary surgeons is sparse.

Methods: Based on literature data, we have investigated the influence of experience with TSS for pituitary adenomas on endocrinological remission rates and on operative complications. Read More

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http://dx.doi.org/10.1007/s11102-018-0904-4DOI Listing
October 2018
1 Read

Single fraction and multisession Gamma Knife radiosurgery for craniopharyngioma.

Pituitary 2018 Oct;21(5):499-506

Department of Neurosurgery, Istituto Scientifico San Raffaele, Vita-Salute University, Via Olgettina 60, 20132, Milano, Italy.

Purpose: The optimal management of residual or recurring craniopharyngioma is still a matter of debate even though adjuvant radiation therapy plays a crucial role. Aim of our study is to report the results of single fraction or multisession Gamma Knife radiosurgery (GKRS) in patients with craniopharyngioma.

Methods: We included 50 consecutive patients treated from 1994 to 2016. Read More

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http://dx.doi.org/10.1007/s11102-018-0903-5DOI Listing
October 2018
8 Reads