403 results match your criteria Pinta


New optimization algorithms for neural network training using operator splitting techniques.

Neural Netw 2020 Jun 26;126:178-190. Epub 2020 Mar 26.

Tiberiu Popoviciu Institute of Numerical Analysis Romanian Academy, Cluj-Napoca, RO-400320, Romania; Department of Mathematics Babeş-Bolyai University, Cluj-Napoca, RO-400084, Romania. Electronic address:

In the following paper we present a new type of optimization algorithms adapted for neural network training. These algorithms are based upon sequential operator splitting technique for some associated dynamical systems. Furthermore, we investigate through numerical simulations the empirical rate of convergence of these iterative schemes toward a local minimum of the loss function, with some suitable choices of the underlying hyper-parameters. Read More

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http://dx.doi.org/10.1016/j.neunet.2020.03.018DOI Listing

Outcomes of sacral neuromodulation for chronic pelvic pain: a Finnish national multicenter study.

Tech Coloproctol 2020 Mar 21;24(3):215-220. Epub 2020 Jan 21.

Turku University Hospital, Turku, Finland.

Background: The aim of this study was to report the outcomes of sacral neuromodulation (SNM) in chronic pelvic pain (CPP) patients in the Finnish national cohort.

Methods: This was a register-based retrospective study, involving all the centers that provide SNM treatment in Finland. The data of all patients treated with SNM for CPP were gathered from Oulu-, Turku-, Tampere- and Helsinki University Hospitals, as well as Jyväskylä and Seinäjoki Central Hospitals. Read More

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http://dx.doi.org/10.1007/s10151-020-02148-2DOI Listing

Advancing the understanding of treponemal disease in the past and present.

Am J Phys Anthropol 2020 May 19;171 Suppl 70:5-41. Epub 2020 Jan 19.

School of Human Evolution and Social Change, Arizona State University, Tempe, Arizona.

Syphilis was perceived to be a new disease in Europe in the late 15th century, igniting a debate about its origin that continues today in anthropological, historical, and medical circles. We move beyond this age-old debate using an interdisciplinary approach that tackles broader questions to advance the understanding of treponemal infection (syphilis, yaws, bejel, and pinta). How did the causative organism(s) and humans co-evolve? How did the related diseases caused by Treponema pallidum emerge in different parts of the world and affect people across both time and space? How are T. Read More

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http://dx.doi.org/10.1002/ajpa.23988DOI Listing

The pan-genome of Treponema pallidum reveals differences in genome plasticity between subspecies related to venereal and non-venereal syphilis.

BMC Genomics 2020 Jan 10;21(1):33. Epub 2020 Jan 10.

Department of Immunology, Microbiology and Parasitology, Institute of Biological Sciences and Natural Sciences, Federal University of Triângulo Mineiro (UFTM), Uberaba, MG, Brazil.

Background: Spirochetal organisms of the Treponema genus are responsible for causing Treponematoses. Pathogenic treponemes is a Gram-negative, motile, spirochete pathogen that causes syphilis in human. Treponema pallidum subsp. Read More

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http://dx.doi.org/10.1186/s12864-019-6430-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6953169PMC
January 2020

The "Scourge of the Renaissance". A Short Review About infection.

Endocr Metab Immune Disord Drug Targets 2020 ;20(3):335-343

Department of Emergency/Urgent, National Poison Center, Riuniti University Hospital (OO.RR.) of Foggia, Foggia, Italy.

Background: There is not a time in the history when epidemics did not loom large: infectious diseases have always had civilisation and evolution-altering consequences. Throughout history, there have been a number of pandemics: cholera, bubonic plague, influenza, smallpox are some of the most brutal killers in human history. Historical accounts of pandemics clearly demonstrate that war, unhygienic conditions, social and health inequality create conditions for the transmission of infectious diseases, and existing health disparities can contribute to unequal morbidity and mortality. Read More

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http://dx.doi.org/10.2174/1871530319666191009144217DOI Listing
January 2020

Controlled-release mitochondrial protonophore (CRMP) reverses dyslipidemia and hepatic steatosis in dysmetabolic nonhuman primates.

Sci Transl Med 2019 10;11(512)

Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06510, USA.

Nonalcoholic fatty liver disease (NAFLD) is estimated to affect up to one-third of the general population, and new therapies are urgently required. Our laboratory previously developed a controlled-release mitochondrial protonophore (CRMP) that is functionally liver-targeted and promotes oxidation of hepatic triglycerides. Although we previously demonstrated that CRMP safely reverses hypertriglyceridemia, fatty liver, hepatic inflammation, and fibrosis in diet-induced rodent models of obesity, there remains a critical need to assess its safety and efficacy in a model highly relevant to humans. Read More

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http://dx.doi.org/10.1126/scitranslmed.aay0284DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996238PMC
October 2019
1 Read
15.843 Impact Factor

Regulation of hepatic mitochondrial oxidation by glucose-alanine cycling during starvation in humans.

J Clin Invest 2019 11;129(11):4671-4675

Department of Medicine.

In order to determine whether the glucose-alanine cycle regulates rates of hepatic mitochondrial oxidation in humans, we applied positional isotopomer NMR tracer analysis (PINTA) to assess rates of hepatic mitochondrial oxidation and pyruvate carboxylase flux in healthy volunteers following both an overnight (12 hours) and a 60-hour fast. Following the 60-hour fast, rates of endogenous glucose production and mitochondrial oxidation decreased, whereas rates of hepatic pyruvate carboxylase flux remained unchanged. These reductions were associated with reduced rates of alanine turnover, assessed by [3-13C]alanine, in a subgroup of participants under similar fasting conditions. Read More

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http://dx.doi.org/10.1172/JCI129913DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6819088PMC
November 2019
1 Read

Efficacy of the adjuvanted recombinant zoster vaccine (RZV) by sex, geographic region, and geographic ancestry/ethnicity: A post-hoc analysis of the ZOE-50 and ZOE-70 randomized trials.

Vaccine 2019 10 16;37(43):6262-6267. Epub 2019 Sep 16.

GSK, 14200 Shady Grove Road, Rockville, MD 20850, USA. Electronic address:

Background: Herpes zoster (HZ) risk appears to vary by sex and geographic ancestry/ethnicity.

Methods: In 2 randomized clinical trials, participants received 2 doses of adjuvanted recombinant zoster vaccine (RZV) or placebo intramuscularly, 2 months apart. In this post-hoc analysis, we investigate efficacy of RZV against HZ and postherpetic neuralgia (PHN) by sex, geographic region, and geographic ancestry/ethnicity in ≥50-year-olds (ZOE-50: NCT01165177) and ≥70-year-olds (pooled data from ZOE-50 and ZOE-70: NCT01165229). Read More

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http://dx.doi.org/10.1016/j.vaccine.2019.09.028DOI Listing
October 2019
3 Reads

Prospective multicentre cohort trial on acute appendicitis and microbiota, aetiology and effects of antimicrobial treatment: study protocol for the MAPPAC (Microbiology APPendicitis ACuta) trial.

BMJ Open 2019 09 6;9(9):e031137. Epub 2019 Sep 6.

Division of Digestive Surgery and Urology, Turku University Hospital, Turku, Finland

Introduction: Based on the epidemiological and clinical data, acute appendicitis can present either as uncomplicated or complicated. The aetiology of these different appendicitis forms remains unknown. Antibiotic therapy has been shown to be safe, efficient and cost-effective for CT-confirmed uncomplicated acute appendicitis. Read More

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http://dx.doi.org/10.1136/bmjopen-2019-031137DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6731800PMC
September 2019
1 Read

Mechanical and oral antibiotic bowel preparation versus no bowel preparation for elective colectomy (MOBILE): a multicentre, randomised, parallel, single-blinded trial.

Lancet 2019 09 8;394(10201):840-848. Epub 2019 Aug 8.

Department of Gastroenterological Surgery, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.

Background: Decreased surgical site infections (SSIs) and morbidity have been reported with mechanical and oral antibiotic bowel preparation (MOABP) compared with no bowel preparation (NBP) in colonic surgery. Several societies have recommended routine use of MOABP in patients undergoing colon resection on the basis of these data. Our aim was to investigate this recommendation in a prospective randomised context. Read More

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http://dx.doi.org/10.1016/S0140-6736(19)31269-3DOI Listing
September 2019
1 Read

Cost-effectiveness of pirfenidone compared to all available strategies for the treatment of idiopathic pulmonary fibrosis in France.

J Mark Access Health Policy 2019 24;7(1):1626171. Epub 2019 Jun 24.

Pulmonology Department, National Coordinating Reference Center for Rare Pulmonary Diseases, Louis Pradel Hospital, University Claude Bernard Lyon 1, Lyon, France.

: To update the health economic evaluation of pirfenidone in the treatment of idiopathic pulmonary fibrosis (IPF) compared to all available alternatives strategies (Best supportive care - BSC and nintedanib), based on a cost-utility model previously validated by the CEESP's (French Committee for Economic Evaluation) in 2014. : A standard Markov cohort model, adapted to French methodology guidelines, was used to simulate the therapeutic management and the course of IPF patients (including potential adverse events) using the collective perspective. Cost-effectiveness was evaluated regarding life years (LY); quality-adjusted life-years (QALY); average cumulative costs; the incremental cost-effectiveness ratio (ICER) expressed in cost per QALY gained. Read More

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http://dx.doi.org/10.1080/20016689.2019.1626171DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6598518PMC
June 2019
4 Reads

Laparoscopic versus hybrid approach for treatment of incisional ventral hernia: a prospective randomised multicentre study, 1-year results.

Surg Endosc 2020 01 2;34(1):88-95. Epub 2019 Apr 2.

Department of Surgery, Oulu University Hospital, Oulu, Finland.

Purpose: Laparoscopic incisional ventral hernia repair (LIVHR) is often followed by seroma formation, bulging and failure to restore abdominal wall function. These outcomes are risk factors for hernia recurrence, chronic pain and poor quality of life (QoL). We aimed to evaluate whether LIVHR combined with defect closure (hybrid) follows as a diminished seroma formation and thereby has a lower rate of hernia recurrence and chronic pain compared to standard LIVHR. Read More

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http://dx.doi.org/10.1007/s00464-019-06735-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6946755PMC
January 2020
24 Reads

Safety profile of the adjuvanted recombinant zoster vaccine: Pooled analysis of two large randomised phase 3 trials.

Vaccine 2019 04 29;37(18):2482-2493. Epub 2019 Mar 29.

GSK, Wavre, Belgium. Electronic address:

Background: The ZOE-50 (NCT01165177) and ZOE-70 (NCT01165229) phase 3 clinical trials showed that the adjuvanted recombinant zoster vaccine (RZV) was ≥90% efficacious in preventing herpes zoster in adults. Here we present a comprehensive overview of the safety data from these studies.

Methods: Adults aged ≥50 (ZOE-50) and ≥70 (ZOE-70) years were randomly vaccinated with RZV or placebo. Read More

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http://dx.doi.org/10.1016/j.vaccine.2019.03.043DOI Listing
April 2019
13 Reads

Comparison of 3D endoanal ultrasound and external phased array magnetic resonance imaging in the diagnosis of obstetric anal sphincter injuries.

Eur Radiol 2019 Oct 26;29(10):5717-5722. Epub 2019 Mar 26.

Department of Surgery, Seinäjoki Central Hospital, Seinäjoki, Finland.

Objectives: The gold standard of postpartum anal sphincter imaging has been the 3D endoanal ultrasound (EAUS). Development of magnetic resonance imaging (MRI) has allowed anal sphincter evaluation without the use of endoanal coils. The aim of this study is to compare these two modalities in diagnosing residual sphincter lesions post obstetric anal sphincter injury (OASI). Read More

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http://dx.doi.org/10.1007/s00330-019-06125-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6717181PMC
October 2019
24 Reads

In vitro cytotoxic effects of secondary metabolites of DEHP and its alternative plasticizers DINCH and DINP on a L929 cell line.

Int J Hyg Environ Health 2019 04 18;222(3):583-589. Epub 2019 Mar 18.

Université Clermont- Auvergne, Imagerie Moléculaire et Stratégies Théranostiques, Inserm U1240, Centre Jean Perrin, BP 184, F-63005, Clermont-Ferrand, France. Electronic address:

Background: Phthalic acid esters are widely used to improve the plasticity of PVC in medical devices (MD). The most famous plasticizer is DEHP, whose use in medical devices has been contested by the European authorities since 2008. Several alternative plasticizers are being considered to replace DEHP, such as DEHT, TOTM, DINP or DINCH, but they are also released from the PVC throughout their life cycle and are metabolized in the same way as DEHP. Read More

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http://dx.doi.org/10.1016/j.ijheh.2019.03.005DOI Listing
April 2019
8 Reads

Potential role of lava lizards as pollinators across the Galápagos Islands.

Integr Zool 2020 Mar;15(2):144-148

Global Change Research Group, Mediterranean Institute for Advanced Studies, Mallorca, Balearic Islands, Spain.

Lizards have been reported as important pollinators on several oceanic islands. Here we evaluate the potential role of Galápagos lava lizards (Microlophus spp.) as pollinators across their radiation. Read More

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http://dx.doi.org/10.1111/1749-4877.12386DOI Listing
March 2020
9 Reads

Optimising the antibiotic treatment of uncomplicated acute appendicitis: a protocol for a multicentre randomised clinical trial (APPAC II trial).

BMC Surg 2018 Dec 17;18(1):117. Epub 2018 Dec 17.

Division of Digestive Surgery and Urology, Turku University Hospital, Kiinanmyllynkatu 4-8, 20520, Turku, Finland.

Background: Based on epidemiological and clinical data acute appendicitis can present either as uncomplicated (70-80%) or complicated (20-30%) disease. Recent studies have shown that antibiotic therapy is both safe and cost-effective for a CT-scan confirmed uncomplicated acute appendicitis. However, based on the study protocols to ensure patient safety, these randomised studies used mainly broad-spectrum intravenous antibiotics requiring additional hospital resources and prolonged hospital stay. Read More

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http://dx.doi.org/10.1186/s12893-018-0451-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6296129PMC
December 2018
6 Reads

Conformational aspects of polymorphs and phases of 2-propyl-1-benzimidazole.

IUCrJ 2018 Nov 14;5(Pt 6):706-715. Epub 2018 Sep 14.

Instituto de Química Médica, Centro de Química Orgánica Manuel Lora-Tamayo, CSIC, Juan de la Cierva 3, Madrid E-28006, Spain.

This paper reports on the polymorphism of 2-propyl-1-benzimidazole (2PrBzIm) induced by temperature change. Upon heating, an irreversible reconstructive-type phase transition at = 384 K from the ordered form (222) to a new polymorph, form (), was observed. The structural transformation between forms and involves significant changes in the crystal packing, as well as a key conformational variation around the propyl chain of the molecule. Read More

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http://dx.doi.org/10.1107/S2052252518011685DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6211527PMC
November 2018
10 Reads

Acquired disorders with depigmentation: A systematic approach to vitiliginoid conditions.

J Am Acad Dermatol 2019 May 17;80(5):1215-1231.e6. Epub 2018 Sep 17.

Department of Dermatology and Pediatric Dermatology, Cutaneous Physiopathology and Integrated Center of Metabolomics Research, San Gallicano Dermatologic Institute, IRCCS, Rome, Italy.

Acquired disorders with depigmentation are commonly encountered by dermatologists and present with a wide differential diagnosis. Vitiligo, the most common disorder of acquired depigmentation, is characterized by well-defined depigmented macules and patches. Other conditions, such as chemical leukoderma, can present with similar findings, and are often easily mistaken for vitiligo. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01909622183250
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http://dx.doi.org/10.1016/j.jaad.2018.03.063DOI Listing
May 2019
22 Reads

Impact of sphincter lesions and delayed sphincter repair on sacral neuromodulation treatment outcomes for faecal incontinence: results from a Finnish national cohort study.

Int J Colorectal Dis 2018 Dec 10;33(12):1709-1714. Epub 2018 Sep 10.

University of Turku, Turku, Finland.

Purpose: The aim of this multicentre study was to analyse the effects of patent sphincter lesions and previous sphincter repair on the results of sacral neuromodulation (SNM) treatment on patients with faecal incontinence (FI).

Methods: Patients examined by endoanal ultrasound (EAUS) with FI as the indication for SNM treatment were included in the study. Data was collected from all the centres providing SNM treatment in Finland and analysed for differences in treatment outcomes. Read More

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http://link.springer.com/10.1007/s00384-018-3161-0
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http://dx.doi.org/10.1007/s00384-018-3161-0DOI Listing
December 2018
35 Reads

Outcomes of treatment of faecal incontinence with sacral nerve stimulation - a Finnish multicentre study.

Colorectal Dis 2019 01 25;21(1):59-65. Epub 2018 Sep 25.

University of Turku, Turku, Finland.

Aim: The aim of this multicentre study is to report the results of sacral nerve stimulation (SNS) treatment for faecal incontinence (FI) in Finland and determine factors that could influence SNS treatment outcomes.

Method: This is a national multicentre study, involving all patients tested for SNS implantation in Finland from 1999 to 2017. Data were collected retrospectively from electronic patient archives and analysed for possible effects on treatment outcome. Read More

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http://dx.doi.org/10.1111/codi.14406DOI Listing
January 2019
5 Reads

Application of Millifluidics to Encapsulate and Support Viable Human Mesenchymal Stem Cells in a Polysaccharide Hydrogel.

Int J Mol Sci 2018 Jul 3;19(7). Epub 2018 Jul 3.

Inserm, UMR 1229, RMeS, Regenerative Medicine and Skeleton, Université de Nantes, ONIRIS, F-44042 Nantes, France.

Human adipose-derived stromal cells (hASCs) are widely known for their immunomodulatory and anti-inflammatory properties. This study proposes a method to protect cells during and after their injection by encapsulation in a hydrogel using a droplet millifluidics technique. A biocompatible, self-hardening biomaterial composed of silanized-hydroxypropylmethylcellulose (Si-HPMC) hydrogel was used and dispersed in an oil continuous phase. Read More

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http://dx.doi.org/10.3390/ijms19071952DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6073862PMC
July 2018
17 Reads

Laparoscopic versus hybrid approach for treatment of incisional ventral hernia: a prospective randomized multicenter study of 1-month follow-up results.

Hernia 2018 12 7;22(6):1015-1022. Epub 2018 Jun 7.

Division of Gastroenterology, Department of Surgery, Oulu University Hospital, PL 21, 90029, Oulu, Finland.

Purpose: The seroma rate following laparoscopic incisional ventral hernia repair (LIVHR) is up to 78%. LIVHR is connected to a relatively rare but dangerous complication, enterotomy, especially in cases with complex adhesiolysis. Closure of the fascial defect and extirpation of the hernia sack may reduce the risk of seromas and other hernia-site events. Read More

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http://dx.doi.org/10.1007/s10029-018-1784-2DOI Listing
December 2018
18 Reads

Point-of-care tests for syphilis and yaws in a low-income setting - A qualitative study of healthcare worker and patient experiences.

PLoS Negl Trop Dis 2018 04 19;12(4):e0006360. Epub 2018 Apr 19.

Clinical Research Department, Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, Keppel Street, London, United Kingdom.

Introduction: The human treponematoses comprise venereal syphilis and the three non-venereal or endemic treponematoses yaws, bejel, and pinta. Serological assays remain the most common diagnostic method for all treponemal infections. Point-of-care tests (POCTs) for syphilis and yaws allow testing without further development of infrastructure in populations where routine laboratory facilities are not available. Read More

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http://dx.doi.org/10.1371/journal.pntd.0006360DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5908063PMC
April 2018
53 Reads

Patients' exposure to PVC plasticizers from ECMO circuits.

Expert Rev Med Devices 2018 May 16;15(5):377-383. Epub 2018 Apr 16.

c CHU Clermont-Ferrand, CNRS, SIGMA Clermont, Institut de Chimie de Clermont-Ferrand , Université Clermont Auvergne , Clermont-Ferrand , France.

Background: ECMO is a therapeutic act with a high risk of exposure to diethylhexylphthalate (DEHP), plasticizer from PVC tubings. The replacement of this plasticizer with alternative compounds is recommended but the risks associated with the use of new plasticizers have not been evaluated in ECMO situations.

Methods: Ex vivo ECMO models were performed with different flow rates over 6 days to evaluate the migration of plasticizers and their potential toxic risk for patient. Read More

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http://dx.doi.org/10.1080/17434440.2018.1462698DOI Listing
May 2018
56 Reads

Genetics of human and animal uncultivable treponemal pathogens.

Infect Genet Evol 2018 07 22;61:92-107. Epub 2018 Mar 22.

Work Group Neglected Tropical Diseases, Pathology Unit, German Primate Center, Leibniz Institute for Primate Research, Kellnerweg 4, 37077 Göttingen, Germany,. Electronic address:

Treponema pallidum is an uncultivable bacterium and the causative agent of syphilis (subsp. pallidum [TPA]), human yaws (subsp. pertenue [TPE]), and bejel (subsp. Read More

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http://dx.doi.org/10.1016/j.meegid.2018.03.015DOI Listing
July 2018
11 Reads

A new species of Acanthobothrium (Eucestoda: Onchobothriidae) in Aetobatus cf. narinari (Myliobatidae) from Campeche, México.

Rev Bras Parasitol Vet 2018 Jan-Mar;27(1):67-74. Epub 2018 Mar 12.

Centro de Investigaciones Biológicas, Universidad Autónoma del Estado de Hidalgo, Pachuca, Hidalgo, México.

The helminthological examination of nine individuals of Aetobatus cf. narinari (spotted eagle ray; raya pinta; arraia pintada) revealed the presence of an undescribed species of cestode of the genus Acanthobothrium. The stingrays were collected from four locations in México: Laguna Términos, south of Isla del Carmen and the marine waters north of Isla del Carmen and Champotón, in the State of Campeche, and Isla Holbox, State of Quintana Roo. Read More

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http://dx.doi.org/10.1590/S1984-29612018009DOI Listing
February 2019
7 Reads

Chemokine expression in the early response to injury in human airway epithelial cells.

PLoS One 2018 13;13(3):e0193334. Epub 2018 Mar 13.

Department of Medicine, University of Chicago, Chicago, IL, United States of America.

Basal airway epithelial cells (AEC) constitute stem/progenitor cells within the central airways and respond to mucosal injury in an ordered sequence of spreading, migration, proliferation, and differentiation to needed cell types. However, dynamic gene transcription in the early events after mucosal injury has not been studied in AEC. We examined gene expression using microarrays following mechanical injury (MI) in primary human AEC grown in submersion culture to generate basal cells and in the air-liquid interface to generate differentiated AEC (dAEC) that include goblet and ciliated cells. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0193334PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5849294PMC
June 2018
6 Reads

Publisher Correction: Non-invasive assessment of hepatic mitochondrial metabolism by positional isotopomer NMR tracer analysis (PINTA).

Nat Commun 2018 01 31;9(1):498. Epub 2018 Jan 31.

Departments of Internal Medicine, Yale University School of Medicine, New Haven, CT, 06520, USA.

The originally published version of this Article contained an error in Equation 30, which was inadvertently introduced during the production process. This has now been corrected in the PDF and HTML versions of the Article. Read More

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http://dx.doi.org/10.1038/s41467-018-03023-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5792489PMC
January 2018
26 Reads
10.740 Impact Factor

Pleomorphic lobular carcinoma: is it more similar to a classic lobular cancer or to a high-grade ductal cancer?

Breast Cancer (Dove Med Press) 2017 8;9:581-586. Epub 2017 Dec 8.

Breast Unit, San Giovanni-Addolorata Hospital, Rome, Italy.

Background: Pleomorphic invasive lobular carcinoma (P-ILC) is an uncommon variety of invasive lobular carcinoma with aggressive clinical features. Little is described in the literature regarding this topic.

Materials And Methods: We reviewed our experiences from 2010 to 2015 and compared 40 patients with P-ILC, 126 patients with classic-ILC (C-ILC) and 574 cases of high-grade invasive ductal carcinoma (HG-IDC). Read More

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https://www.dovepress.com/pleomorphic-lobular-carcinoma-is-i
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http://dx.doi.org/10.2147/BCTT.S145570DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5726360PMC
December 2017
28 Reads

Polysaccharide Hydrogels Support the Long-Term Viability of Encapsulated Human Mesenchymal Stem Cells and Their Ability to Secrete Immunomodulatory Factors.

Stem Cells Int 2017 11;2017:9303598. Epub 2017 Oct 11.

INSERM, UMR 1229, Regenerative Medicine and Skeleton (RMeS), Université de Nantes, ONIRIS, 44042 Nantes, France.

While therapeutically interesting, the injection of MSCs suffers major limitations including cell death upon injection and a massive leakage outside the injection site. We proposed to entrap MSCs within spherical particles derived from alginate, as a control, or from silanized hydroxypropyl methylcellulose (Si-HPMC). We developed water in an oil dispersion method to produce small Si-HPMC particles with an average size of about 68 m. Read More

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http://dx.doi.org/10.1155/2017/9303598DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5660815PMC
October 2017
23 Reads

Copy Number Variation and Expression Analysis Reveals a Nonorthologous Pinta Gene Family Member Involved in Butterfly Vision.

Genome Biol Evol 2017 12;9(12):3398-3412

Department of Ecology and Evolutionary Biology, University of California, Irvine.

Vertebrate (cellular retinaldehyde-binding protein) and Drosophila (prolonged depolarization afterpotential is not apparent [PINTA]) proteins with a CRAL-TRIO domain transport retinal-based chromophores that bind to opsin proteins and are necessary for phototransduction. The CRAL-TRIO domain gene family is composed of genes that encode proteins with a common N-terminal structural domain. Although there is an expansion of this gene family in Lepidoptera, there is no lepidopteran ortholog of pinta. Read More

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http://academic.oup.com/gbe/article/9/12/3398/4609366
Publisher Site
http://dx.doi.org/10.1093/gbe/evx230DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5739039PMC
December 2017
23 Reads

Non-invasive assessment of hepatic mitochondrial metabolism by positional isotopomer NMR tracer analysis (PINTA).

Nat Commun 2017 10 6;8(1):798. Epub 2017 Oct 6.

Departments of Internal Medicine, Yale University School of Medicine, New Haven, CT, 06520, USA.

Hepatic mitochondria play a central role in the regulation of intermediary metabolism and maintenance of normoglycemia, and there is great interest in assessing rates of hepatic mitochondrial citrate synthase flux (V ) and pyruvate carboxylase flux (V ) in vivo. Here, we show that a positional isotopomer NMR tracer analysis (PINTA) method can be used to non-invasively assess rates of V and V fluxes using a combined NMR/gas chromatography-mass spectrometry analysis of plasma following infusion of [3-C]lactate and glucose tracer. PINTA measures V and V fluxes over a wide range of physiological conditions with minimal pyruvate cycling and detects increased hepatic V following treatment with a liver-targeted mitochondrial uncoupler. Read More

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http://dx.doi.org/10.1038/s41467-017-01143-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5630596PMC
October 2017
143 Reads
6 Citations
10.742 Impact Factor

Treatment of symptomatic splenomegaly with low doses of radiotherapy: Retrospective analysis and review of the literature.

Tech Innov Patient Support Radiat Oncol 2017 Sep-Dec;3-4:23-29. Epub 2017 Sep 6.

Ramón y Cajal University Hospital, Madrid, Spain.

Objectives: To evaluate the effectiveness of low doses of radiation therapy for symptomatic splenomegaly in malignant and benign diseases.

Patients And Methods: 5 patients with symptomatic splenomegaly were treated with low doses of radiation in our centre (January 2008-December 2016). 4/5 patients had malignant neoplasia (acute myeloid leukemia, non Hogdkin lymphoma and prolymphocytic B cell leukemia) and splenomegaly was caused by extramedullary hematopoiesis. Read More

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http://dx.doi.org/10.1016/j.tipsro.2017.08.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7033798PMC
September 2017

Effects of Anacetrapib in Patients with Atherosclerotic Vascular Disease.

N Engl J Med 2017 09 28;377(13):1217-1227. Epub 2017 Aug 28.

Clinical Trial Service Unit and Medical Research Council Population Health Research Unit, University of Oxford, Oxford, United Kingdom

Background: Patients with atherosclerotic vascular disease remain at high risk for cardiovascular events despite effective statin-based treatment of low-density lipoprotein (LDL) cholesterol levels. The inhibition of cholesteryl ester transfer protein (CETP) by anacetrapib reduces LDL cholesterol levels and increases high-density lipoprotein (HDL) cholesterol levels. However, trials of other CETP inhibitors have shown neutral or adverse effects on cardiovascular outcomes. Read More

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http://dx.doi.org/10.1056/NEJMoa1706444DOI Listing
September 2017
30 Reads

Efficacy of Selective Grinding Guided by an Occlusal Splint in Management of Myofascial Pain: A Prospective Clinical Trial.

Open Dent J 2017 30;11:301-311. Epub 2017 Jun 30.

Department of Surgery, Faculty of Medicine, University of Salamanca, Salamanca, Spain.

Background: For patients whose centric relation (CR) has not been considered at the start and during treatment, the task of achieving an occlusal scheme that works together with the temporomandibular joint, the muscles, and the structures of the stomatognathic apparatus becomes a major concern.

Objective: This study aims to describe a reproducible, predictable and to date unreported procedure of selective grinding guided by an occlusal splint and to analyze condylar position (CP) based on the skeletal pattern.

Methods: A total of 72 symptomatic patients (38 females and 34 males) were classified into three groups: hyperdivergent, intermediate and hypodivergent. Read More

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http://dx.doi.org/10.2174/1874210601711010301DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5543708PMC
June 2017
92 Reads

Ordered vacancy distribution in 2/1 mullite: a superspace model.

Acta Crystallogr B Struct Sci Cryst Eng Mater 2017 Jun 12;73(Pt 3):377-388. Epub 2017 May 12.

Dpto de Física de la Materia Condensada, Facultad de Ciencia y Tecnología, Universidad del País Vasco UPV/EHU, Apdo 644, Bilbao 48080, Spain.

A mullite single crystal with composition AlSiO exhibiting sharp satellite reflections was investigated by means of X-ray diffraction. For the refinement of a superspace model in the superspace group Pbam(α0½)0ss different scale factors for main and satellite reflections were used in order to describe an ordered mullite structure embedded in a disordered polymorph. The ordered fraction of the mullite sample exhibits a completely ordered vacancy distribution and can be described as a block structure of vacancy blocks (VBs) that alternate with vacancy-free blocks (VFBs) along a and c. Read More

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http://dx.doi.org/10.1107/S2052520617001652DOI Listing
June 2017
8 Reads

Selective solid phase extraction of lanthanides from tap and river waters with ion imprinted polymers.

Anal Chim Acta 2017 Apr 24;963:44-52. Epub 2017 Feb 24.

Laboratory of Analytical, Bioanalytical Sciences and Miniaturization (LSABM), UMR CBI 8231, ESPCI Paris, PSL Research University, Paris, France; CNRS, UMR CBI 8231, Paris, France. Electronic address:

For the first time, an ion imprinted polymer (IIP) able to selectively extract simultaneously all the lanthanide ions was successfully synthesized in acetonitrile using Nd as a template ion, methacrylic acid as a complexing monomer, and ethylene glycol dimethacrylate as a cross-linker. A non-imprinted polymer (NIP) was synthesized under the same conditions as those of the IIP, but in the absence of the template ion. After the removal of the template ions, grounding and sieving, the IIP particles were packed in solid phase extraction (SPE) cartridges. Read More

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http://dx.doi.org/10.1016/j.aca.2017.02.012DOI Listing
April 2017
18 Reads

Functional clues from the crystal structure of an orphan periplasmic ligand-binding protein from Treponema pallidum.

Protein Sci 2017 04 23;26(4):847-856. Epub 2017 Mar 23.

Department of Microbiology, The University of Texas Southwestern Medical Center, Dallas, Texas, 75390.

The spirochete Treponema pallidum is the causative agent of syphilis, a sexually transmitted infection of major global importance. Other closely related subspecies of Treponema also are the etiological agents of the endemic treponematoses, such as yaws, pinta, and bejel. The inability of T. Read More

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http://dx.doi.org/10.1002/pro.3133DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5368063PMC
April 2017
24 Reads

In vitro cytotoxic effects of DEHP-alternative plasticizers and their primary metabolites on a L929 cell line.

Chemosphere 2017 Apr 8;173:452-459. Epub 2017 Jan 8.

Université Clermont Auvergne, INSERM, U1240 Imagerie Moléculaire et Stratégies Théranostiques, F-63000 Clermont Ferrand, France. Electronic address:

Phthalic acid esters have been widely used to improve the plasticity of PVC medical devices. They carry a high exposure risk for both humans and the environment in clinical situations. Our study focuses on the cytotoxicity of alternative plasticizers. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2017.01.026DOI Listing
April 2017
102 Reads

Jaw osteonecrosis associated with aflibercept, irinotecan and fluorouracil: attention to oral district.

Tumori 2016 Nov 11;102(Suppl. 2). Epub 2016 Nov 11.

Colorectal Cancer Unit, Division of Medical Oncology 1, San Giovanni Battista Hospital, Città della Salute e della Scienza, Turin - Italy.

Introduction: The antiangiogenic monoclonal antibody aflibercept in association with fluorouracil and irinotecan improves the survival of patients with metastatic colorectal cancer (mCRC) treated previously with oxaliplatin-based therapy. Multiple reports raised the hypothesis that the concomitant use of antiresorptive drugs and antiangiogenic drugs may increase the risk of osteonecrosis of the jaw (ONJ). Some reports have been published regarding cases of ONJ during treatment with bevacizumab for mCRC. Read More

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http://dx.doi.org/10.5301/tj.5000405DOI Listing
November 2016
91 Reads

Tools for opening new chapters in the book of Treponema pallidum evolutionary history.

Clin Microbiol Infect 2016 Nov 4;22(11):916-921. Epub 2016 Aug 4.

Epidemiology of Highly Pathogenic Microorganisms, Germany. Electronic address:

Treponema pallidum infections causing yaws disease and venereal syphilis are globally widespread in human populations, infecting hundreds of thousands and millions annually respectively; endemic syphilis is much less common, and pinta has not been observed in decades. We discuss controversy surrounding the origin, evolution and history of these pathogens in light of available molecular and anthropological evidence. These bacteria (or close relatives) seem to affect many wild African nonhuman primate (NHP) species, though to date only a single NHP Treponema pallidum genome has been published, hindering detection of spillover events and our understanding of potential wildlife reservoirs. Read More

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http://dx.doi.org/10.1016/j.cmi.2016.07.027DOI Listing
November 2016
13 Reads

Factors predicting a failed primary repair of obstetric anal sphincter injury.

Acta Obstet Gynecol Scand 2016 Sep 18;95(9):1063-9. Epub 2016 May 18.

Department of Surgery, Vaasa Central Hospital, Vaasa, Finland.

Introduction: The success of the primary repair of obstetric anal sphincter injury (OASI) is paramount in maintaining adequate fecal continence after childbirth. The factors determining the success or failure of primary repair are unclear. The aim of this study is to investigate modifiable factors determining the success or failure of the primary sphincter repair after OASI. Read More

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http://dx.doi.org/10.1111/aogs.12909DOI Listing
September 2016
30 Reads

How Far into Europe Did Pikas (Lagomorpha: Ochotonidae) Go during the Pleistocene? New Evidence from Central Iberia.

PLoS One 2015 4;10(11):e0140513. Epub 2015 Nov 4.

Departamento de Paleontología, Facultad de Ciencias Geológicas, Universidad Complutense de Madrid, Madrid, Spain.

This paper reports the first find of pika remains in the Iberian Peninsula, at a site in central Spain. A fragmented mandible of Ochotona cf. pusilla was unearthed from Layer 3 (deposited some 63. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0140513PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4633061PMC
June 2016
14 Reads

Complete mitochondrial genome of the speckled dace Rhinichthys osculus, a widely distributed cyprinid minnow of western North America.

Mitochondrial DNA A DNA Mapp Seq Anal 2016 11 21;27(6):4416-4418. Epub 2015 Oct 21.

a Department of Biological Sciences , Center for Coastal Marine Sciences, California Polytechnic State University , San Luis Obispo , CA , USA.

The speckled dace Rhinichthys osculus (order Cypriniformes), also known as the carpita pinta, is a small cyprinid minnow native to western North America. Here, we report the sequencing of the full mitochondrial genome (mitogenome) of R. osculus from a male fish collected from the Amargosa River Canyon in eastern California, USA. Read More

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http://dx.doi.org/10.3109/19401736.2015.1089551DOI Listing
November 2016
15 Reads

A Retrospective Study on Genetic Heterogeneity within Treponema Strains: Subpopulations Are Genetically Distinct in a Limited Number of Positions.

PLoS Negl Trop Dis 2015 5;9(10):e0004110. Epub 2015 Oct 5.

Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.

Background: Pathogenic uncultivable treponemes comprise human and animal pathogens including agents of syphilis, yaws, bejel, pinta, and venereal spirochetosis in rabbits and hares. A set of 10 treponemal genome sequences including those of 4 Treponema pallidum ssp. pallidum (TPA) strains (Nichols, DAL-1, Mexico A, SS14), 4 T. Read More

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http://dx.doi.org/10.1371/journal.pntd.0004110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4593590PMC
April 2016
18 Reads

Neoadjuvant chemotherapy is not a contraindication for nipple sparing mastectomy.

Breast 2015 Oct 3;24(5):661-6. Epub 2015 Sep 3.

Breast Center -Department of Surgery, San Giovanni-Addolorata Hospital Rome, Via Amba Aradam, 9, 00184 Rome, Italy. Electronic address:

Background: Nipple-sparing mastectomy (NSM) has been recently implemented to improve cosmetic outcome after mastectomy, but it is rarely considered today after neoadjuvant chemotherapy (NCH).

Patients And Methods: Among 275 NSMs performed from January 2007 to January 2015, 186 cases, with a minimum follow-up of 12 months, were carried out for invasive or intraductal carcinoma. Patients were considered for NSM if there were no clinical and radiological evidence of invasion or close proximity (<1 cm) to the nipple-areola complex (NAC). Read More

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http://dx.doi.org/10.1016/j.breast.2015.08.001DOI Listing
October 2015
21 Reads
6 Citations
2.381 Impact Factor

Pinta: Latin America's Forgotten Disease?

Authors:
Lola V Stamm

Am J Trop Med Hyg 2015 Nov 24;93(5):901-3. Epub 2015 Aug 24.

Program in Infectious Diseases, Department of Epidemiology, Gillings School of Global Public Health, Hooker Research Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina

Pinta is a neglected, chronic skin disease that was first described in the sixteenth century in Mexico. The World Health Organization lists 15 countries in Latin America where pinta was previously endemic. However, the current prevalence of pinta is unknown due to the lack of surveillance data. Read More

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http://dx.doi.org/10.4269/ajtmh.15-0329DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4703279PMC
November 2015
27 Reads

Migration of plasticizers from PVC medical devices: Development of an infusion model.

Int J Pharm 2015 Oct 13;494(1):136-45. Epub 2015 Aug 13.

CHU Clermont-Ferrand, Pôle Pharmacie, rue Montalembert, 63003 Clermont-Ferrand, France; Clermont Université, Université d'Auvergne, EA 4676C-BIOSENSS, BP 10448, F-63000 Clermont-Ferrand, France.

Alternatives to DEHP plasticizers are used in various PVC medical devices (MD) for infusion. As they are able to migrate from these MDs into infused solutions, they may come into contact with patient. Different and specific clinical parameters influence their migration in at-risk situations such as infusion. Read More

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http://dx.doi.org/10.1016/j.ijpharm.2015.08.033DOI Listing
October 2015
9 Reads

Nanoporosity, Inclusion Chemistry, and Spin Crossover in Orthogonally Interlocked Two-Dimensional Metal-Organic Frameworks.

Chemistry 2015 Aug 15;21(34):12112-20. Epub 2015 Jul 15.

Instituto de Ciencia Molecular (ICMol), Universidad de Valencia, 46980 Paterna, Valencia (Spain).

[Fe(tvp)2 (NCS)2 ] (1) (tvp=trans-(4,4'-vinylenedipyridine)) consists of two independent perpendicular stacks of mutually interpenetrated two-dimensional grids. This uncommon supramolecular conformation defines square-sectional nanochannels (diagonal≈2.2 nm) in which inclusion molecules are located. Read More

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http://dx.doi.org/10.1002/chem.201500310DOI Listing
August 2015
44 Reads