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    Point-of-care tests for syphilis and yaws in a low-income setting - A qualitative study of healthcare worker and patient experiences.
    PLoS Negl Trop Dis 2018 Apr 19;12(4):e0006360. Epub 2018 Apr 19.
    Clinical Research Department, Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, Keppel Street, London, United Kingdom.
    Introduction: The human treponematoses comprise venereal syphilis and the three non-venereal or endemic treponematoses yaws, bejel, and pinta. Serological assays remain the most common diagnostic method for all treponemal infections. Point-of-care tests (POCTs) for syphilis and yaws allow testing without further development of infrastructure in populations where routine laboratory facilities are not available. Read More

    Patients' exposure to PVC plasticizers from ECMO circuits.
    Expert Rev Med Devices 2018 May 16;15(5):377-383. Epub 2018 Apr 16.
    c CHU Clermont-Ferrand, CNRS, SIGMA Clermont, Institut de Chimie de Clermont-Ferrand , Université Clermont Auvergne , Clermont-Ferrand , France.
    Background: ECMO is a therapeutic act with a high risk of exposure to diethylhexylphthalate (DEHP), plasticizer from PVC tubings. The replacement of this plasticizer with alternative compounds is recommended but the risks associated with the use of new plasticizers have not been evaluated in ECMO situations.

    Methods: Ex vivo ECMO models were performed with different flow rates over 6 days to evaluate the migration of plasticizers and their potential toxic risk for patient. Read More

    Genetics of human and animal uncultivable treponemal pathogens.
    Infect Genet Evol 2018 Jul 22;61:92-107. Epub 2018 Mar 22.
    Work Group Neglected Tropical Diseases, Pathology Unit, German Primate Center, Leibniz Institute for Primate Research, Kellnerweg 4, 37077 Göttingen, Germany,. Electronic address:
    Treponema pallidum is an uncultivable bacterium and the causative agent of syphilis (subsp. pallidum [TPA]), human yaws (subsp. pertenue [TPE]), and bejel (subsp. Read More

    A new species of Acanthobothrium (Eucestoda: Onchobothriidae) in Aetobatus cf. narinari (Myliobatidae) from Campeche, México.
    Rev Bras Parasitol Vet 2018 Jan-Mar;27(1):67-74. Epub 2018 Mar 12.
    Centro de Investigaciones Biológicas, Universidad Autónoma del Estado de Hidalgo, Pachuca, Hidalgo, México.
    The helminthological examination of nine individuals of Aetobatus cf. narinari (spotted eagle ray; raya pinta; arraia pintada) revealed the presence of an undescribed species of cestode of the genus Acanthobothrium. The stingrays were collected from four locations in México: Laguna Términos, south of Isla del Carmen and the marine waters north of Isla del Carmen and Champotón, in the State of Campeche, and Isla Holbox, State of Quintana Roo. Read More

    Chemokine expression in the early response to injury in human airway epithelial cells.
    PLoS One 2018 13;13(3):e0193334. Epub 2018 Mar 13.
    Department of Medicine, University of Chicago, Chicago, IL, United States of America.
    Basal airway epithelial cells (AEC) constitute stem/progenitor cells within the central airways and respond to mucosal injury in an ordered sequence of spreading, migration, proliferation, and differentiation to needed cell types. However, dynamic gene transcription in the early events after mucosal injury has not been studied in AEC. We examined gene expression using microarrays following mechanical injury (MI) in primary human AEC grown in submersion culture to generate basal cells and in the air-liquid interface to generate differentiated AEC (dAEC) that include goblet and ciliated cells. Read More

    Publisher Correction: Non-invasive assessment of hepatic mitochondrial metabolism by positional isotopomer NMR tracer analysis (PINTA).
    Nat Commun 2018 Jan 31;9(1):498. Epub 2018 Jan 31.
    Departments of Internal Medicine, Yale University School of Medicine, New Haven, CT, 06520, USA.
    The originally published version of this Article contained an error in Equation 30, which was inadvertently introduced during the production process. This has now been corrected in the PDF and HTML versions of the Article. Read More

    Pleomorphic lobular carcinoma: is it more similar to a classic lobular cancer or to a high-grade ductal cancer?
    Breast Cancer (Dove Med Press) 2017 8;9:581-586. Epub 2017 Dec 8.
    Breast Unit, San Giovanni-Addolorata Hospital, Rome, Italy.
    Background: Pleomorphic invasive lobular carcinoma (P-ILC) is an uncommon variety of invasive lobular carcinoma with aggressive clinical features. Little is described in the literature regarding this topic.

    Materials And Methods: We reviewed our experiences from 2010 to 2015 and compared 40 patients with P-ILC, 126 patients with classic-ILC (C-ILC) and 574 cases of high-grade invasive ductal carcinoma (HG-IDC). Read More

    Polysaccharide Hydrogels Support the Long-Term Viability of Encapsulated Human Mesenchymal Stem Cells and Their Ability to Secrete Immunomodulatory Factors.
    Stem Cells Int 2017 11;2017:9303598. Epub 2017 Oct 11.
    INSERM, UMR 1229, Regenerative Medicine and Skeleton (RMeS), Université de Nantes, ONIRIS, 44042 Nantes, France.
    While therapeutically interesting, the injection of MSCs suffers major limitations including cell death upon injection and a massive leakage outside the injection site. We proposed to entrap MSCs within spherical particles derived from alginate, as a control, or from silanized hydroxypropyl methylcellulose (Si-HPMC). We developed water in an oil dispersion method to produce small Si-HPMC particles with an average size of about 68 m. Read More

    Copy Number Variation and Expression Analysis Reveals a Nonorthologous Pinta Gene Family Member Involved in Butterfly Vision.
    Genome Biol Evol 2017 Dec;9(12):3398-3412
    Department of Ecology and Evolutionary Biology, University of California, Irvine.
    Vertebrate (cellular retinaldehyde-binding protein) and Drosophila (prolonged depolarization afterpotential is not apparent [PINTA]) proteins with a CRAL-TRIO domain transport retinal-based chromophores that bind to opsin proteins and are necessary for phototransduction. The CRAL-TRIO domain gene family is composed of genes that encode proteins with a common N-terminal structural domain. Although there is an expansion of this gene family in Lepidoptera, there is no lepidopteran ortholog of pinta. Read More

    Non-invasive assessment of hepatic mitochondrial metabolism by positional isotopomer NMR tracer analysis (PINTA).
    Nat Commun 2017 10 6;8(1):798. Epub 2017 Oct 6.
    Departments of Internal Medicine, Yale University School of Medicine, New Haven, CT, 06520, USA.
    Hepatic mitochondria play a central role in the regulation of intermediary metabolism and maintenance of normoglycemia, and there is great interest in assessing rates of hepatic mitochondrial citrate synthase flux (V ) and pyruvate carboxylase flux (V ) in vivo. Here, we show that a positional isotopomer NMR tracer analysis (PINTA) method can be used to non-invasively assess rates of V and V fluxes using a combined NMR/gas chromatography-mass spectrometry analysis of plasma following infusion of [3-C]lactate and glucose tracer. PINTA measures V and V fluxes over a wide range of physiological conditions with minimal pyruvate cycling and detects increased hepatic V following treatment with a liver-targeted mitochondrial uncoupler. Read More

    Effects of Anacetrapib in Patients with Atherosclerotic Vascular Disease.
    N Engl J Med 2017 09 28;377(13):1217-1227. Epub 2017 Aug 28.
    Clinical Trial Service Unit and Medical Research Council Population Health Research Unit, University of Oxford, Oxford, United Kingdom
    Background: Patients with atherosclerotic vascular disease remain at high risk for cardiovascular events despite effective statin-based treatment of low-density lipoprotein (LDL) cholesterol levels. The inhibition of cholesteryl ester transfer protein (CETP) by anacetrapib reduces LDL cholesterol levels and increases high-density lipoprotein (HDL) cholesterol levels. However, trials of other CETP inhibitors have shown neutral or adverse effects on cardiovascular outcomes. Read More

    Efficacy of Selective Grinding Guided by an Occlusal Splint in Management of Myofascial Pain: A Prospective Clinical Trial.
    Open Dent J 2017 30;11:301-311. Epub 2017 Jun 30.
    Department of Surgery, Faculty of Medicine, University of Salamanca, Salamanca, Spain.
    Background: For patients whose centric relation (CR) has not been considered at the start and during treatment, the task of achieving an occlusal scheme that works together with the temporomandibular joint, the muscles, and the structures of the stomatognathic apparatus becomes a major concern.

    Objective: This study aims to describe a reproducible, predictable and to date unreported procedure of selective grinding guided by an occlusal splint and to analyze condylar position (CP) based on the skeletal pattern.

    Methods: A total of 72 symptomatic patients (38 females and 34 males) were classified into three groups: hyperdivergent, intermediate and hypodivergent. Read More

    Ordered vacancy distribution in 2/1 mullite: a superspace model.
    Acta Crystallogr B Struct Sci Cryst Eng Mater 2017 Jun 12;73(Pt 3):377-388. Epub 2017 May 12.
    Dpto de Física de la Materia Condensada, Facultad de Ciencia y Tecnología, Universidad del País Vasco UPV/EHU, Apdo 644, Bilbao 48080, Spain.
    A mullite single crystal with composition AlSiO exhibiting sharp satellite reflections was investigated by means of X-ray diffraction. For the refinement of a superspace model in the superspace group Pbam(α0½)0ss different scale factors for main and satellite reflections were used in order to describe an ordered mullite structure embedded in a disordered polymorph. The ordered fraction of the mullite sample exhibits a completely ordered vacancy distribution and can be described as a block structure of vacancy blocks (VBs) that alternate with vacancy-free blocks (VFBs) along a and c. Read More

    Selective solid phase extraction of lanthanides from tap and river waters with ion imprinted polymers.
    Anal Chim Acta 2017 Apr 24;963:44-52. Epub 2017 Feb 24.
    Laboratory of Analytical, Bioanalytical Sciences and Miniaturization (LSABM), UMR CBI 8231, ESPCI Paris, PSL Research University, Paris, France; CNRS, UMR CBI 8231, Paris, France. Electronic address:
    For the first time, an ion imprinted polymer (IIP) able to selectively extract simultaneously all the lanthanide ions was successfully synthesized in acetonitrile using Nd as a template ion, methacrylic acid as a complexing monomer, and ethylene glycol dimethacrylate as a cross-linker. A non-imprinted polymer (NIP) was synthesized under the same conditions as those of the IIP, but in the absence of the template ion. After the removal of the template ions, grounding and sieving, the IIP particles were packed in solid phase extraction (SPE) cartridges. Read More

    Functional clues from the crystal structure of an orphan periplasmic ligand-binding protein from Treponema pallidum.
    Protein Sci 2017 Apr 23;26(4):847-856. Epub 2017 Mar 23.
    Department of Microbiology, The University of Texas Southwestern Medical Center, Dallas, Texas, 75390.
    The spirochete Treponema pallidum is the causative agent of syphilis, a sexually transmitted infection of major global importance. Other closely related subspecies of Treponema also are the etiological agents of the endemic treponematoses, such as yaws, pinta, and bejel. The inability of T. Read More

    In vitro cytotoxic effects of DEHP-alternative plasticizers and their primary metabolites on a L929 cell line.
    Chemosphere 2017 Apr 8;173:452-459. Epub 2017 Jan 8.
    Université Clermont Auvergne, INSERM, U1240 Imagerie Moléculaire et Stratégies Théranostiques, F-63000 Clermont Ferrand, France. Electronic address:
    Phthalic acid esters have been widely used to improve the plasticity of PVC medical devices. They carry a high exposure risk for both humans and the environment in clinical situations. Our study focuses on the cytotoxicity of alternative plasticizers. Read More

    Jaw osteonecrosis associated with aflibercept, irinotecan and fluorouracil: attention to oral district.
    Tumori 2016 Nov 11;102(Suppl. 2). Epub 2016 Nov 11.
    Colorectal Cancer Unit, Division of Medical Oncology 1, San Giovanni Battista Hospital, Città della Salute e della Scienza, Turin - Italy.
    Introduction: The antiangiogenic monoclonal antibody aflibercept in association with fluorouracil and irinotecan improves the survival of patients with metastatic colorectal cancer (mCRC) treated previously with oxaliplatin-based therapy. Multiple reports raised the hypothesis that the concomitant use of antiresorptive drugs and antiangiogenic drugs may increase the risk of osteonecrosis of the jaw (ONJ). Some reports have been published regarding cases of ONJ during treatment with bevacizumab for mCRC. Read More

    Tools for opening new chapters in the book of Treponema pallidum evolutionary history.
    Clin Microbiol Infect 2016 Nov 4;22(11):916-921. Epub 2016 Aug 4.
    Epidemiology of Highly Pathogenic Microorganisms, Germany. Electronic address:
    Treponema pallidum infections causing yaws disease and venereal syphilis are globally widespread in human populations, infecting hundreds of thousands and millions annually respectively; endemic syphilis is much less common, and pinta has not been observed in decades. We discuss controversy surrounding the origin, evolution and history of these pathogens in light of available molecular and anthropological evidence. These bacteria (or close relatives) seem to affect many wild African nonhuman primate (NHP) species, though to date only a single NHP Treponema pallidum genome has been published, hindering detection of spillover events and our understanding of potential wildlife reservoirs. Read More

    Factors predicting a failed primary repair of obstetric anal sphincter injury.
    Acta Obstet Gynecol Scand 2016 Sep 18;95(9):1063-9. Epub 2016 May 18.
    Department of Surgery, Vaasa Central Hospital, Vaasa, Finland.
    Introduction: The success of the primary repair of obstetric anal sphincter injury (OASI) is paramount in maintaining adequate fecal continence after childbirth. The factors determining the success or failure of primary repair are unclear. The aim of this study is to investigate modifiable factors determining the success or failure of the primary sphincter repair after OASI. Read More

    How Far into Europe Did Pikas (Lagomorpha: Ochotonidae) Go during the Pleistocene? New Evidence from Central Iberia.
    PLoS One 2015 4;10(11):e0140513. Epub 2015 Nov 4.
    Departamento de Paleontología, Facultad de Ciencias Geológicas, Universidad Complutense de Madrid, Madrid, Spain.
    This paper reports the first find of pika remains in the Iberian Peninsula, at a site in central Spain. A fragmented mandible of Ochotona cf. pusilla was unearthed from Layer 3 (deposited some 63. Read More

    Complete mitochondrial genome of the speckled dace Rhinichthys osculus, a widely distributed cyprinid minnow of western North America.
    Mitochondrial DNA A DNA Mapp Seq Anal 2016 11 21;27(6):4416-4418. Epub 2015 Oct 21.
    a Department of Biological Sciences , Center for Coastal Marine Sciences, California Polytechnic State University , San Luis Obispo , CA , USA.
    The speckled dace Rhinichthys osculus (order Cypriniformes), also known as the carpita pinta, is a small cyprinid minnow native to western North America. Here, we report the sequencing of the full mitochondrial genome (mitogenome) of R. osculus from a male fish collected from the Amargosa River Canyon in eastern California, USA. Read More

    A Retrospective Study on Genetic Heterogeneity within Treponema Strains: Subpopulations Are Genetically Distinct in a Limited Number of Positions.
    PLoS Negl Trop Dis 2015 5;9(10):e0004110. Epub 2015 Oct 5.
    Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.
    Background: Pathogenic uncultivable treponemes comprise human and animal pathogens including agents of syphilis, yaws, bejel, pinta, and venereal spirochetosis in rabbits and hares. A set of 10 treponemal genome sequences including those of 4 Treponema pallidum ssp. pallidum (TPA) strains (Nichols, DAL-1, Mexico A, SS14), 4 T. Read More

    Neoadjuvant chemotherapy is not a contraindication for nipple sparing mastectomy.
    Breast 2015 Oct 3;24(5):661-6. Epub 2015 Sep 3.
    Breast Center -Department of Surgery, San Giovanni-Addolorata Hospital Rome, Via Amba Aradam, 9, 00184 Rome, Italy. Electronic address:
    Background: Nipple-sparing mastectomy (NSM) has been recently implemented to improve cosmetic outcome after mastectomy, but it is rarely considered today after neoadjuvant chemotherapy (NCH).

    Patients And Methods: Among 275 NSMs performed from January 2007 to January 2015, 186 cases, with a minimum follow-up of 12 months, were carried out for invasive or intraductal carcinoma. Patients were considered for NSM if there were no clinical and radiological evidence of invasion or close proximity (<1 cm) to the nipple-areola complex (NAC). Read More

    Pinta: Latin America's Forgotten Disease?
    Am J Trop Med Hyg 2015 Nov 24;93(5):901-3. Epub 2015 Aug 24.
    Program in Infectious Diseases, Department of Epidemiology, Gillings School of Global Public Health, Hooker Research Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
    Pinta is a neglected, chronic skin disease that was first described in the sixteenth century in Mexico. The World Health Organization lists 15 countries in Latin America where pinta was previously endemic. However, the current prevalence of pinta is unknown due to the lack of surveillance data. Read More

    Migration of plasticizers from PVC medical devices: Development of an infusion model.
    Int J Pharm 2015 Oct 13;494(1):136-45. Epub 2015 Aug 13.
    CHU Clermont-Ferrand, Pôle Pharmacie, rue Montalembert, 63003 Clermont-Ferrand, France; Clermont Université, Université d'Auvergne, EA 4676C-BIOSENSS, BP 10448, F-63000 Clermont-Ferrand, France.
    Alternatives to DEHP plasticizers are used in various PVC medical devices (MD) for infusion. As they are able to migrate from these MDs into infused solutions, they may come into contact with patient. Different and specific clinical parameters influence their migration in at-risk situations such as infusion. Read More

    Nanoporosity, Inclusion Chemistry, and Spin Crossover in Orthogonally Interlocked Two-Dimensional Metal-Organic Frameworks.
    Chemistry 2015 Aug 15;21(34):12112-20. Epub 2015 Jul 15.
    Instituto de Ciencia Molecular (ICMol), Universidad de Valencia, 46980 Paterna, Valencia (Spain).
    [Fe(tvp)2 (NCS)2 ] (1) (tvp=trans-(4,4'-vinylenedipyridine)) consists of two independent perpendicular stacks of mutually interpenetrated two-dimensional grids. This uncommon supramolecular conformation defines square-sectional nanochannels (diagonal≈2.2 nm) in which inclusion molecules are located. Read More

    Psychosocial Interventions for Problem Alcohol Use in Primary Care Settings (PINTA): Baseline Feasibility Data.
    J Dual Diagn 2015 ;11(2):97-106
    Objective: Many individuals receiving methadone maintenance receive their treatment through their primary care provider. As many also drink alcohol excessively, there is a need to address alcohol use to improve health outcomes for these individuals. We examined problem alcohol use and its treatment among people attending primary care for methadone maintenance treatment, using baseline data from a feasibility study of an evidence-based complex intervention to improve care. Read More

    Efficacy of an adjuvanted herpes zoster subunit vaccine in older adults.
    N Engl J Med 2015 May 28;372(22):2087-96. Epub 2015 Apr 28.
    The authors' affiliations are listed in the Appendix.
    Background: In previous phase 1-2 clinical trials involving older adults, a subunit vaccine containing varicella-zoster virus glycoprotein E and the AS01B adjuvant system (called HZ/su) had a clinically acceptable safety profile and elicited a robust immune response.

    Methods: We conducted a randomized, placebo-controlled, phase 3 study in 18 countries to evaluate the efficacy and safety of HZ/su in older adults (≥50 years of age), stratified according to age group (50 to 59, 60 to 69, and ≥70 years). Participants received two intramuscular doses of the vaccine or placebo 2 months apart. Read More

    Disease gene prioritization using network and feature.
    J Comput Biol 2015 Apr;22(4):313-23
    1 Department of Computer Science, Illinois Institute of Technology , Chicago, Illinois.
    Identifying high-confidence candidate genes that are causative for disease phenotypes, from the large lists of variations produced by high-throughput genomics, can be both time-consuming and costly. The development of novel computational approaches, utilizing existing biological knowledge for the prioritization of such candidate genes, can improve the efficiency and accuracy of the biomedical data analysis. It can also reduce the cost of such studies by avoiding experimental validations of irrelevant candidates. Read More

    Migrability of PVC plasticizers from medical devices into a simulant of infused solutions.
    Int J Pharm 2015 May 18;485(1-2):341-7. Epub 2015 Mar 18.
    CHU Clermont-Ferrand, Pôle Pharmacie, rue Montalembert, 6300 Clermont-Ferrand, France; Clermont Université, Université d'Auvergne, EA 467 C-BIOSENSS, BP 10448, F-6300 Clermont-Ferrand, France.
    Medical devices (MD) for infusion and artificial nutrition are essentially made of plasticized PVC. The plasticizers in the PVC matrix can leach out into the infused solutions and may enter into contact with the patients. In order to assess the risk of patient exposure to these plasticizers we evaluated the migration performance of DEHP, DEHT, DINCH, and TOTM using a model adapted to the clinical use of the MDs. Read More

    Molecular evolution and expression of the CRAL_TRIO protein family in insects.
    Insect Biochem Mol Biol 2015 Jul 13;62:168-73. Epub 2015 Feb 13.
    Department of Ecology and Evolutionary Biology, University of California, Irvine, CA 92697, USA.
    CRAL_TRIO domain proteins are known to bind small lipophilic molecules such as retinal, inositol and Vitamin E and include such gene family members as PINTA, α-tocopherol transfer (ATT) proteins, retinoid binding proteins, and clavesins. In insects, very little is known about either the molecular evolution of this family of proteins or their ligand specificity. Here we characterize insect CRAL_TRIO domain proteins and present the first insect CRAL_TRIO protein phylogeny constructed by performing reciprocal BLAST searches of the reference genomes of Drosophila melanogaster, Anopheles gambiae, Apis mellifera, Tribolium castaneum, Bombyx mori, Manduca sexta and Danaus plexippus. Read More

    Endemic treponemal diseases.
    Trans R Soc Trop Med Hyg 2014 Oct 25;108(10):601-7. Epub 2014 Aug 25.
    Clinical Research Department, Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, Keppel Street, London, WC1E 7HT, UK Hospital for Tropical Diseases, University College London Hospitals NHS Trust, London, WC1E 6JB, UK.
    The endemic treponemal diseases, consisting of yaws, bejel (endemic syphilis) and pinta, are non-venereal infections closely related to syphilis, and are recognized by WHO as neglected tropical diseases (NTDs). Despite previous worldwide eradication efforts the prevalence of yaws has rebounded in recent years and the disease is now a major public health problem in 14 countries. Adequate data on the epidemiology of bejel and pinta is lacking. Read More

    [Seroprevalence of measles, rubella, mumps and varicella in health workers in the Community of Madrid].
    Rev Esp Quimioter 2014 Jun;27(2):98-101
    Maria Luisa Rodríguez de la Pinta. Servicio de Prevención de Riesgos Laborales. Hospital Universitario Puerta de Hierro Majadahonda, Calle Joaquín Rodrigo Nº 2, 28220 Majadahonda, Madrid, Spain.
    Background: The vaccination of health workers has a large repercussion on the health of the workers, the patients and the population in general. Due to this, we proposed to discover the serological status for varicella, rubella, mumps and measles in the workers of a tertiary hospital in Madrid.

    Methods: We have conducted a retrospective epidemiological study of 1060 health workers, obtaining information such as age, sex, service area, employment status, pre-exposure vaccination and post-vaccination serology and vaccination status. Read More

    Influence of pharmaceutical care on the delayed emesis associated with chemotherapy.
    Int J Clin Pharm 2014 Apr 31;36(2):287-90. Epub 2014 Jan 31.
    Virgen Macarena University Hospital, C/La Pinta, 94, CP 41927, Seville, Spain,
    Background: Complete control of emesis during chemotherapy remains to be achieved. This could be improved by increasing adherence to medicines and recommendations.

    Objective: The aim of this study was to analyse the effects of pharmaceutical care on the incidence of delayed chemotherapy-induced nausea and vomiting (CINV) in adult cancer outpatients. Read More

    Risk of first cervical HPV infection and pre-cancerous lesions after onset of sexual activity: analysis of women in the control arm of the randomized, controlled PATRICIA trial.
    BMC Infect Dis 2014 Oct 30;14:551. Epub 2014 Oct 30.
    GlaxoSmithKline Vaccines, Wavre, Belgium.
    Background: More information is needed about time between sexual initiation and human papillomavirus (HPV) infection and development of cervical precancer.

    Methods: The objectives were to investigate the time between first sexual activity and detection of first cervical HPV infection or development of first cervical intraepithelial neoplasia (CIN), and associated factors in women from the double-blind, multinational, 4-year PATRICIA trial. PATRICIA enroled women aged 15-25 years with no more than 6 lifetime sexual partners. Read More

    Pilot clinical trial on the efficacy of prophylactic use of vitamin K1-based cream (Vigorskin) to prevent cetuximab-induced skin rash in patients with metastatic colorectal cancer.
    Clin Colorectal Cancer 2014 Mar 13;13(1):62-7. Epub 2013 Nov 13.
    Colorectal Cancer Unit, Medical Oncology 1 Division, San Giovanni Battista Hospital, Turin, Italy.
    Background: Cetuximab is an effective option for the treatment of metastatic colorectal cancer in the first and subsequent lines of treatment; among its side effects, acneiform skin rash is one of the major causes of treatment delay, reduction, or interruption, with a negative effect on quality of life. No effective strategy to prevent skin rash induced by epidermal growth factor receptor inhibitors is available; however, encouraging results have come from vitamin K1, phytomenadione, applied as a topical formulation. Available studies have been conducted in heterogeneous populations and are mainly focused on the use of vitamin K1-based cream for the treatment, rather than the prophylaxis, of acneiform rash. Read More

    Natural history of progression of HPV infection to cervical lesion or clearance: analysis of the control arm of the large, randomised PATRICIA study.
    PLoS One 2013 19;8(11):e79260. Epub 2013 Nov 19.
    Department of Obstetrics and Gynaecology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
    Background: The control arm of PATRICIA (PApilloma TRIal against Cancer In young Adults, NCT00122681) was used to investigate the risk of progression from cervical HPV infection to cervical intraepithelial neoplasia (CIN) or clearance of infection, and associated determinants.

    Methods And Findings: Women aged 15-25 years were enrolled. A 6-month persistent HPV infection (6MPI) was defined as detection of the same HPV type at two consecutive evaluations over 6 months and clearance as ≥2 type-specific HPV negative samples taken at two consecutive intervals of approximately 6 months following a positive sample. Read More

    Advances in the diagnosis of endemic treponematoses: yaws, bejel, and pinta.
    PLoS Negl Trop Dis 2013 24;7(10):e2283. Epub 2013 Oct 24.
    Barcelona Centre for International Health Research, Hospital Clínic, University of Barcelona, Barcelona, Spain ; Lihir Medical Centre-InternationalSOS, Lihir Island, Papua New Guinea.
    Improved understanding of the differential diagnosis of endemic treponematoses is needed to inform clinical practice and to ensure the best outcome for a new global initiative for the eradication of yaws, bejel, and pinta. Traditionally, the human treponematoses have been differentiated based upon their clinical manifestations and epidemiologic characteristics because the etiologic agents are indistinguishable in the laboratory. Serological tests are still considered standard laboratory methods for the diagnosis of endemic treponematoses and new rapid point-of-care treponemal tests have become available which are extremely useful in low-resource settings. Read More

    Psychosocial interventions for alcohol use among problem drug users: protocol for a feasibility study in primary care.
    JMIR Res Protoc 2013 Aug 2;2(2):e26. Epub 2013 Aug 2.
    Centre for Interventions in Infection, Immunity and Inflammation (4i) and Graduate Entry Medical School, Faculty of Education & Health Sciences, University of Limerick, Limerick, Ireland.
    Background: Alcohol use is an important issue among problem drug users. Although screening and brief intervention (SBI) are effective in reducing problem alcohol use in primary care, no research has examined this issue among problem drug users.

    Objective: The objective of this study is to determine if a complex intervention including SBI for problem alcohol use among problem drug users is feasible and acceptable in practice. Read More

    Safety and immunogenicity of an AS01-adjuvanted varicella-zoster virus subunit candidate vaccine against herpes zoster in adults >=50 years of age.
    J Infect Dis 2013 Dec 31;208(12):1953-61. Epub 2013 Jul 31.
    Department of Epidemiology, Faculty of Military Health Sciences, University of Defence, Hradec Kralove, Czech Republic.
    Background: An adjuvanted varicella-zoster virus glycoprotein E (gE) subunit vaccine candidate for herpes zoster is in development. In this trial we compared the safety, reactogenicity, and immunogenicity of the vaccine antigen combined with different adjuvant doses.

    Methods: This was a phase II, observer-blind, randomized, multinational study. Read More

    Equivalency of Galápagos giant tortoises used as ecological replacement species to restore ecosystem functions.
    Conserv Biol 2013 Aug 26;27(4):701-9. Epub 2013 Mar 26.
    State University of New York College of Environmental Science and Forestry, 1 Forestry Drive, Syracuse, NY 13210, USA.
    Loss of key plant-animal interactions (e.g., disturbance, seed dispersal, and herbivory) due to extinctions of large herbivores has diminished ecosystem functioning nearly worldwide. Read More

    From badge of pride to cause of stigma: combatting mal del pinto in Mexico.
    Endeavour 2013 Mar 17;37(1):13-20. Epub 2013 Jan 17.
    Department of Public Health, Faculty of Medicine, National Autonomous University of Mexico, Ciudad Universitaria, Facultad de Medicina, Edificio B. 6to. piso, Copilco el Alto, CP 04510, México DF, Mexico.
    Mal del pinto is a dermatological disease characterized by discoloured patches of skin on the face and body. It has been present in what is now the territory of Mexico from before the Spanish conquest up to recent times. Though early concerns for mal del pinto as a public health problem can be traced back to the late 19th century, no campaign to combat the disease was undertaken until the second half of the 20th. Read More

    Variable compliance with clinical practice guidelines identified in a 1-day audit at 66 French adult intensive care units.
    Crit Care Med 2012 Dec;40(12):3189-95
    Service d'Anesthésie et de Réanimation, Hôpital Nord, Aix-Marseille Univ, Marseille, France.
    Objective: Clinical guidelines should provide a framework for managing patients hospitalized in intensive care units. Little is known about guideline compliance in real-life practice. To evaluate compliance rates for a large bundle of intensive care unit practice guidelines and determine factors associated with noncompliance to these guidelines. Read More

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