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    1 OF 8

    Functional clues from the crystal structure of an orphan periplasmic ligand-binding protein from Treponema pallidum.
    Protein Sci 2017 Feb 7. Epub 2017 Feb 7.
    Department of Microbiology, The University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.
    The spirochete Treponema pallidum is the causative agent of syphilis, a sexually transmitted infection of major global importance. Other closely related subspecies of Treponema also are the etiological agents of the endemic treponematoses, such as yaws, pinta, and bejel. The inability of T. Read More

    In vitro cytotoxic effects of DEHP-alternative plasticizers and their primary metabolites on a L929 cell line.
    Chemosphere 2017 Apr 8;173:452-459. Epub 2017 Jan 8.
    Université Clermont Auvergne, INSERM, U1240 Imagerie Moléculaire et Stratégies Théranostiques, F-63000 Clermont Ferrand, France. Electronic address:
    Phthalic acid esters have been widely used to improve the plasticity of PVC medical devices. They carry a high exposure risk for both humans and the environment in clinical situations. Our study focuses on the cytotoxicity of alternative plasticizers. Read More

    Jaw osteonecrosis associated with aflibercept, irinotecan and fluorouracil: attention to oral district.
    Tumori 2016 Nov 11;102(Suppl. 2). Epub 2016 Nov 11.
    Colorectal Cancer Unit, Division of Medical Oncology 1, San Giovanni Battista Hospital, Città della Salute e della Scienza, Turin - Italy.
    Introduction: The antiangiogenic monoclonal antibody aflibercept in association with fluorouracil and irinotecan improves the survival of patients with metastatic colorectal cancer (mCRC) treated previously with oxaliplatin-based therapy. Multiple reports raised the hypothesis that the concomitant use of antiresorptive drugs and antiangiogenic drugs may increase the risk of osteonecrosis of the jaw (ONJ). Some reports have been published regarding cases of ONJ during treatment with bevacizumab for mCRC. Read More

    Tools for opening new chapters in the book of Treponema pallidum evolutionary history.
    Clin Microbiol Infect 2016 Nov 4;22(11):916-921. Epub 2016 Aug 4.
    Epidemiology of Highly Pathogenic Microorganisms, Germany. Electronic address:
    Treponema pallidum infections causing yaws disease and venereal syphilis are globally widespread in human populations, infecting hundreds of thousands and millions annually respectively; endemic syphilis is much less common, and pinta has not been observed in decades. We discuss controversy surrounding the origin, evolution and history of these pathogens in light of available molecular and anthropological evidence. These bacteria (or close relatives) seem to affect many wild African nonhuman primate (NHP) species, though to date only a single NHP Treponema pallidum genome has been published, hindering detection of spillover events and our understanding of potential wildlife reservoirs. Read More

    Factors predicting a failed primary repair of obstetric anal sphincter injury.
    Acta Obstet Gynecol Scand 2016 Sep 18;95(9):1063-9. Epub 2016 May 18.
    Department of Surgery, Vaasa Central Hospital, Vaasa, Finland.
    Introduction: The success of the primary repair of obstetric anal sphincter injury (OASI) is paramount in maintaining adequate fecal continence after childbirth. The factors determining the success or failure of primary repair are unclear. The aim of this study is to investigate modifiable factors determining the success or failure of the primary sphincter repair after OASI. Read More

    How Far into Europe Did Pikas (Lagomorpha: Ochotonidae) Go during the Pleistocene? New Evidence from Central Iberia.
    PLoS One 2015 4;10(11):e0140513. Epub 2015 Nov 4.
    Departamento de Paleontología, Facultad de Ciencias Geológicas, Universidad Complutense de Madrid, Madrid, Spain.
    This paper reports the first find of pika remains in the Iberian Peninsula, at a site in central Spain. A fragmented mandible of Ochotona cf. pusilla was unearthed from Layer 3 (deposited some 63. Read More

    Complete mitochondrial genome of the speckled dace Rhinichthys osculus, a widely distributed cyprinid minnow of western North America.
    Mitochondrial DNA A DNA Mapp Seq Anal 2016 Nov 21;27(6):4416-4418. Epub 2015 Oct 21.
    a Department of Biological Sciences , Center for Coastal Marine Sciences, California Polytechnic State University , San Luis Obispo , CA , USA.
    The speckled dace Rhinichthys osculus (order Cypriniformes), also known as the carpita pinta, is a small cyprinid minnow native to western North America. Here, we report the sequencing of the full mitochondrial genome (mitogenome) of R. osculus from a male fish collected from the Amargosa River Canyon in eastern California, USA. Read More

    A Retrospective Study on Genetic Heterogeneity within Treponema Strains: Subpopulations Are Genetically Distinct in a Limited Number of Positions.
    PLoS Negl Trop Dis 2015 5;9(10):e0004110. Epub 2015 Oct 5.
    Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.
    Background: Pathogenic uncultivable treponemes comprise human and animal pathogens including agents of syphilis, yaws, bejel, pinta, and venereal spirochetosis in rabbits and hares. A set of 10 treponemal genome sequences including those of 4 Treponema pallidum ssp. pallidum (TPA) strains (Nichols, DAL-1, Mexico A, SS14), 4 T. Read More

    Neoadjuvant chemotherapy is not a contraindication for nipple sparing mastectomy.
    Breast 2015 Oct 3;24(5):661-6. Epub 2015 Sep 3.
    Breast Center -Department of Surgery, San Giovanni-Addolorata Hospital Rome, Via Amba Aradam, 9, 00184 Rome, Italy. Electronic address:
    Background: Nipple-sparing mastectomy (NSM) has been recently implemented to improve cosmetic outcome after mastectomy, but it is rarely considered today after neoadjuvant chemotherapy (NCH).

    Patients And Methods: Among 275 NSMs performed from January 2007 to January 2015, 186 cases, with a minimum follow-up of 12 months, were carried out for invasive or intraductal carcinoma. Patients were considered for NSM if there were no clinical and radiological evidence of invasion or close proximity (<1 cm) to the nipple-areola complex (NAC). Read More

    Pinta: Latin America's Forgotten Disease?
    Am J Trop Med Hyg 2015 Nov 24;93(5):901-3. Epub 2015 Aug 24.
    Program in Infectious Diseases, Department of Epidemiology, Gillings School of Global Public Health, Hooker Research Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
    Pinta is a neglected, chronic skin disease that was first described in the sixteenth century in Mexico. The World Health Organization lists 15 countries in Latin America where pinta was previously endemic. However, the current prevalence of pinta is unknown due to the lack of surveillance data. Read More

    Migration of plasticizers from PVC medical devices: Development of an infusion model.
    Int J Pharm 2015 Oct 13;494(1):136-45. Epub 2015 Aug 13.
    CHU Clermont-Ferrand, Pôle Pharmacie, rue Montalembert, 63003 Clermont-Ferrand, France; Clermont Université, Université d'Auvergne, EA 4676C-BIOSENSS, BP 10448, F-63000 Clermont-Ferrand, France.
    Alternatives to DEHP plasticizers are used in various PVC medical devices (MD) for infusion. As they are able to migrate from these MDs into infused solutions, they may come into contact with patient. Different and specific clinical parameters influence their migration in at-risk situations such as infusion. Read More

    Nanoporosity, Inclusion Chemistry, and Spin Crossover in Orthogonally Interlocked Two-Dimensional Metal-Organic Frameworks.
    Chemistry 2015 Aug 15;21(34):12112-20. Epub 2015 Jul 15.
    Instituto de Ciencia Molecular (ICMol), Universidad de Valencia, 46980 Paterna, Valencia (Spain).
    [Fe(tvp)2 (NCS)2 ] (1) (tvp=trans-(4,4'-vinylenedipyridine)) consists of two independent perpendicular stacks of mutually interpenetrated two-dimensional grids. This uncommon supramolecular conformation defines square-sectional nanochannels (diagonal≈2.2 nm) in which inclusion molecules are located. Read More

    Psychosocial Interventions for Problem Alcohol Use in Primary Care Settings (PINTA): Baseline Feasibility Data.
    J Dual Diagn 2015 ;11(2):97-106
    Objective: Many individuals receiving methadone maintenance receive their treatment through their primary care provider. As many also drink alcohol excessively, there is a need to address alcohol use to improve health outcomes for these individuals. We examined problem alcohol use and its treatment among people attending primary care for methadone maintenance treatment, using baseline data from a feasibility study of an evidence-based complex intervention to improve care. Read More

    Efficacy of an adjuvanted herpes zoster subunit vaccine in older adults.
    N Engl J Med 2015 May 28;372(22):2087-96. Epub 2015 Apr 28.
    The authors' affiliations are listed in the Appendix.
    Background: In previous phase 1-2 clinical trials involving older adults, a subunit vaccine containing varicella-zoster virus glycoprotein E and the AS01B adjuvant system (called HZ/su) had a clinically acceptable safety profile and elicited a robust immune response.

    Methods: We conducted a randomized, placebo-controlled, phase 3 study in 18 countries to evaluate the efficacy and safety of HZ/su in older adults (≥50 years of age), stratified according to age group (50 to 59, 60 to 69, and ≥70 years). Participants received two intramuscular doses of the vaccine or placebo 2 months apart. Read More

    Disease gene prioritization using network and feature.
    J Comput Biol 2015 Apr;22(4):313-23
    1 Department of Computer Science, Illinois Institute of Technology , Chicago, Illinois.
    Identifying high-confidence candidate genes that are causative for disease phenotypes, from the large lists of variations produced by high-throughput genomics, can be both time-consuming and costly. The development of novel computational approaches, utilizing existing biological knowledge for the prioritization of such candidate genes, can improve the efficiency and accuracy of the biomedical data analysis. It can also reduce the cost of such studies by avoiding experimental validations of irrelevant candidates. Read More

    Migrability of PVC plasticizers from medical devices into a simulant of infused solutions.
    Int J Pharm 2015 May 18;485(1-2):341-7. Epub 2015 Mar 18.
    CHU Clermont-Ferrand, Pôle Pharmacie, rue Montalembert, 6300 Clermont-Ferrand, France; Clermont Université, Université d'Auvergne, EA 467 C-BIOSENSS, BP 10448, F-6300 Clermont-Ferrand, France.
    Medical devices (MD) for infusion and artificial nutrition are essentially made of plasticized PVC. The plasticizers in the PVC matrix can leach out into the infused solutions and may enter into contact with the patients. In order to assess the risk of patient exposure to these plasticizers we evaluated the migration performance of DEHP, DEHT, DINCH, and TOTM using a model adapted to the clinical use of the MDs. Read More

    Molecular evolution and expression of the CRAL_TRIO protein family in insects.
    Insect Biochem Mol Biol 2015 Jul 13;62:168-73. Epub 2015 Feb 13.
    Department of Ecology and Evolutionary Biology, University of California, Irvine, CA 92697, USA.
    CRAL_TRIO domain proteins are known to bind small lipophilic molecules such as retinal, inositol and Vitamin E and include such gene family members as PINTA, α-tocopherol transfer (ATT) proteins, retinoid binding proteins, and clavesins. In insects, very little is known about either the molecular evolution of this family of proteins or their ligand specificity. Here we characterize insect CRAL_TRIO domain proteins and present the first insect CRAL_TRIO protein phylogeny constructed by performing reciprocal BLAST searches of the reference genomes of Drosophila melanogaster, Anopheles gambiae, Apis mellifera, Tribolium castaneum, Bombyx mori, Manduca sexta and Danaus plexippus. Read More

    Endemic treponemal diseases.
    Trans R Soc Trop Med Hyg 2014 Oct 25;108(10):601-7. Epub 2014 Aug 25.
    Clinical Research Department, Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, Keppel Street, London, WC1E 7HT, UK Hospital for Tropical Diseases, University College London Hospitals NHS Trust, London, WC1E 6JB, UK.
    The endemic treponemal diseases, consisting of yaws, bejel (endemic syphilis) and pinta, are non-venereal infections closely related to syphilis, and are recognized by WHO as neglected tropical diseases (NTDs). Despite previous worldwide eradication efforts the prevalence of yaws has rebounded in recent years and the disease is now a major public health problem in 14 countries. Adequate data on the epidemiology of bejel and pinta is lacking. Read More

    [Seroprevalence of measles, rubella, mumps and varicella in health workers in the Community of Madrid].
    Rev Esp Quimioter 2014 Jun;27(2):98-101
    Maria Luisa Rodríguez de la Pinta. Servicio de Prevención de Riesgos Laborales. Hospital Universitario Puerta de Hierro Majadahonda, Calle Joaquín Rodrigo Nº 2, 28220 Majadahonda, Madrid, Spain.
    Background: The vaccination of health workers has a large repercussion on the health of the workers, the patients and the population in general. Due to this, we proposed to discover the serological status for varicella, rubella, mumps and measles in the workers of a tertiary hospital in Madrid.

    Methods: We have conducted a retrospective epidemiological study of 1060 health workers, obtaining information such as age, sex, service area, employment status, pre-exposure vaccination and post-vaccination serology and vaccination status. Read More

    Influence of pharmaceutical care on the delayed emesis associated with chemotherapy.
    Int J Clin Pharm 2014 Apr 31;36(2):287-90. Epub 2014 Jan 31.
    Virgen Macarena University Hospital, C/La Pinta, 94, CP 41927, Seville, Spain,
    Background: Complete control of emesis during chemotherapy remains to be achieved. This could be improved by increasing adherence to medicines and recommendations.

    Objective: The aim of this study was to analyse the effects of pharmaceutical care on the incidence of delayed chemotherapy-induced nausea and vomiting (CINV) in adult cancer outpatients. Read More

    Risk of first cervical HPV infection and pre-cancerous lesions after onset of sexual activity: analysis of women in the control arm of the randomized, controlled PATRICIA trial.
    BMC Infect Dis 2014 Oct 30;14:551. Epub 2014 Oct 30.
    GlaxoSmithKline Vaccines, Wavre, Belgium.
    Background: More information is needed about time between sexual initiation and human papillomavirus (HPV) infection and development of cervical precancer.

    Methods: The objectives were to investigate the time between first sexual activity and detection of first cervical HPV infection or development of first cervical intraepithelial neoplasia (CIN), and associated factors in women from the double-blind, multinational, 4-year PATRICIA trial. PATRICIA enroled women aged 15-25 years with no more than 6 lifetime sexual partners. Read More

    Pilot clinical trial on the efficacy of prophylactic use of vitamin K1-based cream (Vigorskin) to prevent cetuximab-induced skin rash in patients with metastatic colorectal cancer.
    Clin Colorectal Cancer 2014 Mar 13;13(1):62-7. Epub 2013 Nov 13.
    Colorectal Cancer Unit, Medical Oncology 1 Division, San Giovanni Battista Hospital, Turin, Italy.
    Background: Cetuximab is an effective option for the treatment of metastatic colorectal cancer in the first and subsequent lines of treatment; among its side effects, acneiform skin rash is one of the major causes of treatment delay, reduction, or interruption, with a negative effect on quality of life. No effective strategy to prevent skin rash induced by epidermal growth factor receptor inhibitors is available; however, encouraging results have come from vitamin K1, phytomenadione, applied as a topical formulation. Available studies have been conducted in heterogeneous populations and are mainly focused on the use of vitamin K1-based cream for the treatment, rather than the prophylaxis, of acneiform rash. Read More

    Natural history of progression of HPV infection to cervical lesion or clearance: analysis of the control arm of the large, randomised PATRICIA study.
    PLoS One 2013 19;8(11):e79260. Epub 2013 Nov 19.
    Department of Obstetrics and Gynaecology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
    Background: The control arm of PATRICIA (PApilloma TRIal against Cancer In young Adults, NCT00122681) was used to investigate the risk of progression from cervical HPV infection to cervical intraepithelial neoplasia (CIN) or clearance of infection, and associated determinants.

    Methods And Findings: Women aged 15-25 years were enrolled. A 6-month persistent HPV infection (6MPI) was defined as detection of the same HPV type at two consecutive evaluations over 6 months and clearance as ≥2 type-specific HPV negative samples taken at two consecutive intervals of approximately 6 months following a positive sample. Read More

    Advances in the diagnosis of endemic treponematoses: yaws, bejel, and pinta.
    PLoS Negl Trop Dis 2013 24;7(10):e2283. Epub 2013 Oct 24.
    Barcelona Centre for International Health Research, Hospital Clínic, University of Barcelona, Barcelona, Spain ; Lihir Medical Centre-InternationalSOS, Lihir Island, Papua New Guinea.
    Improved understanding of the differential diagnosis of endemic treponematoses is needed to inform clinical practice and to ensure the best outcome for a new global initiative for the eradication of yaws, bejel, and pinta. Traditionally, the human treponematoses have been differentiated based upon their clinical manifestations and epidemiologic characteristics because the etiologic agents are indistinguishable in the laboratory. Serological tests are still considered standard laboratory methods for the diagnosis of endemic treponematoses and new rapid point-of-care treponemal tests have become available which are extremely useful in low-resource settings. Read More

    Psychosocial interventions for alcohol use among problem drug users: protocol for a feasibility study in primary care.
    JMIR Res Protoc 2013 Aug 2;2(2):e26. Epub 2013 Aug 2.
    Centre for Interventions in Infection, Immunity and Inflammation (4i) and Graduate Entry Medical School, Faculty of Education & Health Sciences, University of Limerick, Limerick, Ireland.
    Background: Alcohol use is an important issue among problem drug users. Although screening and brief intervention (SBI) are effective in reducing problem alcohol use in primary care, no research has examined this issue among problem drug users.

    Objective: The objective of this study is to determine if a complex intervention including SBI for problem alcohol use among problem drug users is feasible and acceptable in practice. Read More

    Safety and immunogenicity of an AS01-adjuvanted varicella-zoster virus subunit candidate vaccine against herpes zoster in adults >=50 years of age.
    J Infect Dis 2013 Dec 31;208(12):1953-61. Epub 2013 Jul 31.
    Department of Epidemiology, Faculty of Military Health Sciences, University of Defence, Hradec Kralove, Czech Republic.
    Background: An adjuvanted varicella-zoster virus glycoprotein E (gE) subunit vaccine candidate for herpes zoster is in development. In this trial we compared the safety, reactogenicity, and immunogenicity of the vaccine antigen combined with different adjuvant doses.

    Methods: This was a phase II, observer-blind, randomized, multinational study. Read More

    Equivalency of Galápagos giant tortoises used as ecological replacement species to restore ecosystem functions.
    Conserv Biol 2013 Aug 26;27(4):701-9. Epub 2013 Mar 26.
    State University of New York College of Environmental Science and Forestry, 1 Forestry Drive, Syracuse, NY 13210, USA.
    Loss of key plant-animal interactions (e.g., disturbance, seed dispersal, and herbivory) due to extinctions of large herbivores has diminished ecosystem functioning nearly worldwide. Read More

    From badge of pride to cause of stigma: combatting mal del pinto in Mexico.
    Endeavour 2013 Mar 17;37(1):13-20. Epub 2013 Jan 17.
    Department of Public Health, Faculty of Medicine, National Autonomous University of Mexico, Ciudad Universitaria, Facultad de Medicina, Edificio B. 6to. piso, Copilco el Alto, CP 04510, México DF, Mexico.
    Mal del pinto is a dermatological disease characterized by discoloured patches of skin on the face and body. It has been present in what is now the territory of Mexico from before the Spanish conquest up to recent times. Though early concerns for mal del pinto as a public health problem can be traced back to the late 19th century, no campaign to combat the disease was undertaken until the second half of the 20th. Read More

    Variable compliance with clinical practice guidelines identified in a 1-day audit at 66 French adult intensive care units.
    Crit Care Med 2012 Dec;40(12):3189-95
    Service d'Anesthésie et de Réanimation, Hôpital Nord, Aix-Marseille Univ, Marseille, France.
    Objective: Clinical guidelines should provide a framework for managing patients hospitalized in intensive care units. Little is known about guideline compliance in real-life practice. To evaluate compliance rates for a large bundle of intensive care unit practice guidelines and determine factors associated with noncompliance to these guidelines. Read More

    Lack of benefit of 3-month intensification with enfuvirtide plus optimized background regimen (OBR) versus OBR alone in patients with multiple therapeutic failures: the INNOVE study.
    J Med Virol 2012 Nov;84(11):1710-8
    Laboratory of Virology, AP-HP, CHU Saint-Antoine, UPMC University Paris 06, INSERM U943, Paris, France.
    The objective of the present study was to evaluate the virological efficacy of a 3-month short-course intensification with enfuvirtide (ENF) associated with an optimized background regimen (OBR) in treatment-experienced patients infected with HIV-1 with multiple therapeutic failures. This was a prospective, randomized, open-label multicenter trial including patients infected with HIV-1 and harboring a multi-resistant virus that was still susceptible to at least 2 active compounds. Patients were randomized (1:1) to receive OBR + ENF or OBR alone. Read More

    [Spanish Society of Anaesthesia (SEDAR) guidelines for pre-anaesthesia checking procedures].
    Rev Esp Anestesiol Reanim 2012 Apr 28;59(4):210-6. Epub 2012 Apr 28.
    Servicio de Anestesiología, Fundación Jiménez Díaz, Madrid, España.
    We present this document as a guide to preparing a specific institutional pre-anaesthesia checklist, as recommended in the Helsinki declaration on patient safety in anaesthesiology. Also, the recently recommended WHO "safe surgery check-list" includes a check-list for anaesthesia. A working group was established in accordance with the charter of the Spanish Society of Anaesthesiology and Resuscitation (Sociedad Española de Anestesiología y Reanimación [SEDAR]). Read More

    PDA (prolonged depolarizing afterpotential)-defective mutants: the story of nina's and ina's--pinta and santa maria, too.
    J Neurogenet 2012 Jun 27;26(2):216-37. Epub 2012 Jan 27.
    Department of Biological Sciences, Purdue University, 915 W. State Street, West Lafayette, IN 47907-2054, USA.
    Our objective is to present a comprehensive view of the PDA (prolonged depolarizing afterpotential)-defective Drosophila mutants, nina's and ina's, from the discussion of the PDA and the PDA-based mutant screening strategy to summaries of the knowledge gained through the studies of mutants generated using the strategy. The PDA is a component of the light-evoked photoreceptor potential that is generated when a substantial fraction of rhodopsin is photoconverted to its active form, metarhodopsin. The PDA-based mutant screening strategy was adopted to enhance the efficiency and efficacy of ERG (electroretinogram)-based screening for identifying phototransduction-defective mutants. Read More

    Pegylated interferon-α2a plus ribavirin for chronic hepatitis C in a real-life setting: the Hepatys French cohort (2003-2007).
    Antivir Ther 2012 ;17(1):101-10
    Service d'Hépato-Gastroentérologie, Hôpital Saint-Joseph, Marseille, France.
    Background: The aim of this study was to document in real life the characteristics and management of hepatitis C patients treated with pegylated interferon-α2a and ribavirin, and the efficacy of treatment (sustained virological response [SVR]).

    Methods: This observational study enrolled hepatitis C patients initiating pegylated interferon-α2a and ribavirin treatment.

    Results: A total of 2,066 patients were included, of which 70% were treatment-naive, 53% had genotype (G) 1 and 38% G2 or G3 infection, and 35% had an F3-F4 Metavir score. Read More

    Fibrosis progression under maintenance interferon in hepatitis C is better detected by blood test than liver morphometry.
    J Viral Hepat 2012 Feb 30;19(2):e143-53. Epub 2011 Oct 30.
    Liver-Gastroenterology Department, University Hospital, Angers, France.
    We evaluated whether quantitative measurements of liver fibrosis with recently developed diagnostics outperform histological staging in detecting natural or interferon-induced changes. We compared Metavir staging, morphometry (area and fractal dimension) and six blood tests in 157 patients with chronic hepatitis C from two trials testing maintenance interferon for 96 weeks. Paired liver biopsies and blood tests were available for 101 patients, and there was a significant improvement in Metavir activity and a significant increase in blood tests reflecting fibrosis quantity in patients treated with interferon when compared with controls - all per cent changes in histological fibrosis measures were significantly increased in F1 vs F2-4 stages only in the interferon group. Read More

    Genetic diversity in Treponema pallidum: implications for pathogenesis, evolution and molecular diagnostics of syphilis and yaws.
    Infect Genet Evol 2012 Mar 15;12(2):191-202. Epub 2011 Dec 15.
    Department of Biology, Faculty of Medicine, Masaryk University, Kamenice 5, Building A6, 625 00 Brno, Czech Republic.
    Pathogenic uncultivable treponemes, similar to syphilis-causing Treponema pallidum subspecies pallidum, include T. pallidum ssp. pertenue, T. Read More

    Hemolytic uremic syndrome induced by infusion of oxaliplatin: a case report.
    Tumori 2011 Sep-Oct;97(5):31e-3e
    SSCVD Colorectal Cancer Unit, and 2SC Medical Oncology 1, AOU San Giovanni Battista, Turin, Italy.
    Introduction: Oxaliplatin is a third-generation platinum compound with proven antitumor activity in the treatment of colorectal cancer. The occurrence of life-threating hemolitic uremic syndrome has been observed after oxaliplatin therapy. The kind of tumor and treatment modalities seem to influence the onset of hemolitic uremic syndrome. Read More

    Identification of three oligo-/polysaccharide-specific ligases in Yersinia enterocolitica.
    Mol Microbiol 2012 Jan 28;83(1):125-36. Epub 2011 Nov 28.
    Department of Bacteriology and Immunology, Haartman Institute, University of Helsinki, Helsinki, Finland.
    In lipopolysaccharide (LPS) biosynthesis of gram-negative bacteria the lipid A-core oligosaccharide (LA-core) and O-polysaccharide (O-PS) biosynthesis pathways proceed separately and converge in periplasmic space where the waaL-encoded ligase joins O-PS onto LA-core. Enterobacterial common antigen (ECA) biosynthesis follows that of O-PS except that ECA is usually ligated to phosphatidylglycerol (PG) and only rarely to LA-core. In Yersinia enterocolitica serotype O:3 LPS is composed of LA-inner core (IC) onto which a homopolymeric O-PS, a hexasaccharide called outer core (OC), and/or ECA are ligated. Read More

    Pharmacological exposure to ribavirin: a key player in the complex network of factors implicated in virological response and anaemia in hepatitis C treatment.
    Dig Liver Dis 2011 Nov 18;43(11):850-5. Epub 2011 May 18.
    Federation d'Hépatologie, CHU de Limoges, Limoges, France.
    Ribavirin remains today a pivotal drug in the treatment of hepatitis C; in standard double therapy, as well as in triple combination with direct antiviral agents, ribavirin reduces relapse and can double the sustained virological response obtained with peginterferon alone or in association with direct antiviral agents. In the complex network of interacting factors determining sustained virological response independently of known predictive factors related to host and virus, two modern tools are emerging: polymorphisms in the IL28B gene and very early exposure to ribavirin. The use of a pharmacokinetic-pharmacodynamic model of early ribavirin exposure to adjust the dose individually would help promote a safer ribavirin use and improve sustained virological response. Read More

    Bridging, terminal, free, anti and gauche BPA ligands in a 1D hybrid organic-inorganic Mn(II)-cyanate system.
    Dalton Trans 2011 Jun 3;40(22):6033-7. Epub 2011 May 3.
    Departamento de Química Inorgánica, Fac. Ciencia y Tecnología, UPV/EHU, Aptdo. 644, 48080, Bilbao, Spain.
    A hybrid organic-inorganic chain compound of the family Mn(II)-bpa-(NCO) is presented. It contains, unusually, five different dispositions for the bpa [1,2-bis(4-pyridyl)ethane] ligand. Water molecules and free bpa ligands occupy the voids of the structure. Read More

    Sterilisation of hybrid Galapagos tortoises (Geochelone nigra) for island restoration. Part 2: phallectomy of males under intrathecal anaesthesia with lidocaine.
    Vet Rec 2011 Jan 17;168(3):78. Epub 2011 Jan 17.
    Zoo Atlanta, Atlanta, GA 30315, USA.
    Lidocaine intrathecal anaesthesia was used to perform phallectomies in 15 hybrid Galapagos tortoises (Geochelone nigra) in a field setting as part of a conservation and ecosystem restoration project in the Galapagos Islands. The intrathecal injection was performed in the dorsal intercoccygeal region of the tail. Once the tail and hindlimbs were relaxed and the phallus was easily exteriorised, phallectomy was performed in a routine manner. Read More

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