3,157 results match your criteria Pineal Tumors

High Myoinositol on Proton MR Spectroscopy Could Be a Potential Signature of Papillary Tumors of the Pineal Region-Case Report of Two Patients.

Brain Sci 2022 Jun 19;12(6). Epub 2022 Jun 19.

Institut de Diagnóstic per la Imatge (IDI), Department of Radiology, Hospital de Bellvitge, 08908 L'Hospitalet de Llobregat, Barcelona, Spain.

Papillary tumor of the pineal region (PTPR) is an uncommon entity in which a presurgical suspicion may be crucial for patient management. Maximal safe neurosurgical resection is of choice when PTPR is suspected, whereas non-surgical approaches can be considered in other tumors of the pineal region, such as pineocytoma or concrete subtypes of germ-cell tumors. In general terms, imaging features of tumors of the pineal region have been reported to be unspecific. Read More

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Pineal region teratoma with metastases in uncommon locations: a case report.

J Med Case Rep 2022 Jun 23;16(1):261. Epub 2022 Jun 23.

Department of Neurology, Al Assad Damascus University Hospital, Damascus, Syria.

Background: We report a rare case in medical literature of a patient with pineal gland teratoma and uncommon metastases. Usually, metastases of this kind of tumor are located in several organs such as lung and breast, but here we found metastases to the spinal cord and vertebrae.

Case Presentation: A 35-year-old Asian white man presented with diplopia and acute neural symptoms in the lower limbs such as numbness, tingling, and paralysis. Read More

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A homogeneous treatment for non-DIPG diffuse midline glioma.

Tumori 2022 Jun 16:3008916221099067. Epub 2022 Jun 16.

Pediatric Oncology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.

Introduction: The H3K27M-mutant diffuse midline glioma (DMG) was first included in the World Health Organization (WHO) Classification of central nervous system (CNS) tumors in 2016, and confirmed in its fifth edition. The biological behavior and dismal prognosis of this tumor resemble diffuse intrinsic pontine gliomas (DIPG). Homogeneously-treated series are rarely reported. Read More

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Multifocal primary intracranial yolk sac tumor in an adult patient: a case report and literature review.

Transl Cancer Res 2022 May;11(5):1429-1433

Department of Neurosurgery, First Hospital of Jilin University, Changchun, China.

Background: Yolk sac tumor is a type of germ cell tumor. It commonly arises in the gonads but sometimes can occur outside the gonads. Primary intracranial yolk sac tumors were very rare. Read More

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Neuroendoscopy in the management of pineal region tumours in children.

Childs Nerv Syst 2022 Jun 3. Epub 2022 Jun 3.

Department of Neurosurgery, Bombay Hospital Institute of Medical Sciences, New Marine Lines, Mumbai, Maharashtra, India, 400020.

Introduction: Pineal region tumours (PRTs) are more common in children and represent a wide variety of lesions. The practise of a radiation test dose is obsolete and a biochemical/histological diagnosis is recommended before further therapy. Many patients present with hydrocephalus. Read More

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Deep Learning-Based Protein Features Predict Overall Survival and Chemotherapy Benefit in Gastric Cancer.

Front Oncol 2022 16;12:847706. Epub 2022 May 16.

Chongqing Key Laboratory of Big Data for Bio Intelligence, School of Bioinformation, Chongqing University of Posts and Telecommunications, Chongqing, China.

Gastric cancer (GC) is one of the most common malignant tumors with a high mortality rate worldwide and lacks effective methods for prognosis prediction. Postoperative adjuvant chemotherapy is the first-line treatment for advanced gastric cancer, but only a subgroup of patients benefits from it. Here, we used 833 formalin-fixed, paraffin-embedded resected tumor samples from patients with TNM stage II/III GC and established a proteomic subtyping workflow using 100 deep-learned features. Read More

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A case of bilateral uveitis associated with seminoma/germinoma in thymus and pineal glands, two primary lesions.

Am J Ophthalmol Case Rep 2022 Sep 18;27:101589. Epub 2022 May 18.

Division of Ophthalmology, Shinseikai Toyama Hospital, Imizu, Toyama, Japan.

Purpose: To report a case of bilateral ocular paraneoplastic syndrome by seminoma/germinoma in thymus and pineal glands, two primary lesions.

Observations: A 18-year-old male presented at a local clinic complaining of just floaters in left eye without any other clinical signs and symptoms. The treating ophthalmologist found bilateral uveitis, and referred to our hospital. Read More

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September 2022

Survival and associated predictors for patients with pineoblastoma or pineal parenchymal tumors of intermediate differentiation older than 3 years: Insights from the National Cancer Database.

Neurooncol Adv 2022 Jan-Dec;4(1):vdac057. Epub 2022 Apr 17.

Department of Medical Oncology, Mayo Clinic, Rochester, Minnesota, USA.

Background: The management of pineal parenchymal tumors remains controversial.

Methods: The 2004-2017 National Cancer Database was queried for cases (age >3 years) with histologically confirmed pineal parenchymal tumors of intermediate differentiation (PPTID, n = 90) or pineoblastoma (n = 106).

Results: Within the PPTID group, median age was 41 years; 49% were males. Read More

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Miscellaneous newly recognized types of CNS tumors in the WHO CNS5 classification (other than gliomas, glioneuronal and embryonal tumors).

Indian J Pathol Microbiol 2022 May;65(Supplement):S94-S98

Department of Histopathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

In this review, we describe salient features of a few of the newer entities recognized in the fifth edition of World Health Organization (WHO) classification of central nervous system (CNS) tumors. While most of these have been offshoots of the deoxyribonucleic acid (DNA) methylation profiling of CNS tumors with distinct profiling such as desmoplastic myxoid tumor (DMT) of the pineal region, SMARCB1-mutant, these also demonstrate subtle, distinct morphological features, which should be carefully searched for to diagnose them. Read More

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Supratentorial Pediatric Midline Tumors and Tumor-like Lesions: Clinical Spectrum, Natural History and Treatment Options.

Children (Basel) 2022 Apr 9;9(4). Epub 2022 Apr 9.

Division of Neurosurgery, Department of Clinical Neurosciences, Geneva University Hospitals, 1205 Geneva, Switzerland.

Childhood Central Nervous System tumors account for 25% of all pediatric tumors. Large availability and broadening of indications to imaging has made incidental findings more common. Among these, midline lesions have different clinical relevance depending on their intrinsic pattern of behaviour and on their specific location. Read More

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Herophilus-Galen line as a predictor of extent of resection in the occipital interhemispheric transtentorial approach to pineal tumors in children.

J Neurosurg Pediatr 2022 Apr 22:1-9. Epub 2022 Apr 22.

2Pediatric Neuroradiology, and.

Objective: The goals of this study were to evaluate the extent of resection (EOR) obtained with an occipital interhemispheric transtentorial approach (OITA) in a series of pediatric patients with pineal region tumors and to define preoperative radiological factors predictive of the EOR.

Methods: This is a retrospective cohort study of a series of pediatric patients with pineal tumors who underwent surgery through a microsurgical OITA performed by the senior author during the period from January 2006 to January 2020. The tumor volume was measured preoperatively, and then on sagittal midline cuts the authors identified the most cranial point of the torcular Herophili (defined as the "Herophilus point") and the lowest point of the inferior profile of the vein of Galen (defined as the "Galen point"). Read More

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Epidemiology, Management, and Long-Term Survival Outcomes of Intracranial Typical Site Germinomas: An Analysis of the Surveillance, Epidemiology, and End-Results (SEER) Database.

Cancer Control 2022 Jan-Dec;29:10732748221095944

Department of Clinical Research, 162698The First Affiliated Hospital of Jinan University, Guangzhou, China.

Background: The correlations of epidemiological characteristics and clinical outcomes with different tumor sites in patients with intracranial typical site germinomas (ICTSGs) have not yet been well established. We analyzed ICTSGs using a multicenter database, focusing on its demographic, management patterns, and long-term survival outcomes.

Methods: Patients diagnosed with ICTSGs were selected from the Surveillance, Epidemiology, and End-Results (SEER) database. Read More

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Commentary: Malignant Pineal Parenchymal Tumors in Adults: A National Cancer Database Analysis.

Neurosurgery 2022 06 12;90(6):e146. Epub 2022 Apr 12.

Department of Neurological Surgery, University of Miami Miller School of Medicine, Miami, Florida, USA.

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DICER1 mutations in primary central nervous system tumors: new insights into histologies, mutations, and prognosis.

J Neurooncol 2022 May 6;157(3):499-510. Epub 2022 Apr 6.

Department of Radiation Oncology, Harvard Medical School, Brigham and Women's Hospital, Boston Children's Hospital, Dana-Farber Cancer Institute, 450 Brookline Avenue D1622, Boston, MA, 02215-5418, USA.

Purpose: We sought to characterize clinical outcomes for adult and pediatric patients with primary CNS tumors harboring DICER1 mutations or loss of DICER1.

Methods: We conducted a retrospective cohort study of 98 patients who were treated between 1995 and 2020 for primary CNS tumors containing DICER1 mutations or loss of DICER1 on chromosome 14q, identified by targeted next generation sequencing. Kaplan-Meier plots and log rank tests were used to analyze survival. Read More

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Malignant Pineal Parenchymal Tumors in Adults: A National Cancer Database Analysis.

Neurosurgery 2022 06 23;90(6):807-815. Epub 2022 Mar 23.

Department of Neurosurgery, West Virginia University, Martinsburg, West Virginia, USA.

Background: Limited retrospective data exist on malignant pineal parenchymal tumors (PPTs) in adults, and there are no large previous studies that review clinical outcomes across the 3 treatment arms of surgery, radiotherapy, and chemotherapy. As a result, optimal disease management has yet to be defined.

Objective: To evaluate treatment trends and perform survival analysis in adult PPT. Read More

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Coincident pineocytoma and probable brainstem glioma in a child with 22q11.2 deletion syndrome.

BMJ Case Rep 2022 03 10;15(3). Epub 2022 Mar 10.

Department of Neurosciences and Pediatrics, University of California San Diego, La Jolla, California, USA

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Panhypopituitarism in a patient with a hypothalamic and pineal germ cell tumor.

Endocrinol Diabetes Metab Case Rep 2022 Mar 1;2022. Epub 2022 Mar 1.

Department of Endocrinology, Lahey Hospital and Medical Center, Burlington, Massachusetts, USA.

Summary: Central diabetes insipidus (DI) is characterized by decreased release of antidiuretic hormone, resulting in a variable degree of polyuria. The etiologies are variable, with the vast majority of cases either being idiopathic or resulting from primary or secondary tumors. Such tumors include craniopharyngioma, Langerhans cell histiocytosis, or a variety of inflammatory, vascular, or granulomatous diseases. Read More

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Malignant pinealoma observed in the deep cerebral parenchyma of a male Wistar rat.

J Toxicol Pathol 2022 Jan 25;35(1):117-121. Epub 2021 Nov 25.

Pathology Division, BoZo Research Center Inc., 1284 Kamado, Gotemba-shi, Shizuoka 412-0039, Japan.

This report describes a case of spontaneous malignant pinealoma in a 90-week-old male Wistar rat. The tumor mass occurred in the deep cerebral parenchyma and no intact pineal gland was observed in the area between the posterior-dorsal median line of the cerebrum and the cerebellum. The tumor was characterized by a large nodular proliferation occupying the central area of the brain, extending from the dorsal surface to the base of the brain, corresponding to the thalamus. Read More

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January 2022

Pineal Region Gliomas: A Systematic Review of Clinical Features and Treatment Outcomes.

Anticancer Res 2022 Mar;42(3):1189-1198

Texas A&M University College of Medicine, Houston, TX, U.S.A.

Background/aim: To review the current literature on pineal region gliomas, summarizing the clinical characteristics and treatment outcomes.

Materials And Methods: PubMed, Scopus, and Cochrane databases were used to identify relevant articles. Comprehensive clinical characteristic review and survival analysis were conducted. Read More

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Adult Primary Pineal Alveolar Rhabdomyosarcoma with FOXO1 Gene Rearrangement and OLIG2 Expression: A Rare Case Report and Literature Review.

Int J Surg Pathol 2022 Feb 21:10668969221080076. Epub 2022 Feb 21.

74630Affiliated Hangzhou First People's Hospital Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.

Alveolar rhabdomyosarcoma is a common malignant soft tissue tumor in child and adolescents. Intracranial alveolar rhabdomyosarcoma in adults is rare, especially in the pineal region. We present a case of primary alveolar rhabdomyosarcoma of the pineal gland in a 36-year-old Chinese male with a chief complaint of dizziness, headache and a loss of balance when walking. Read More

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February 2022

Combined Microscopic and Endoscopic Surgery for Pineal Region Meningiomas Using the Occipital-Parietal Transtentorial Approach.

Front Oncol 2022 4;12:828361. Epub 2022 Feb 4.

Department of Neurosurgery, The First Affiliated Hospital of Soochow University, Suzhou, China.

Objective: Pineal region meningiomas are deeply located and adjacent to critical neurovascular structures, making them one of the most challenging areas to access. The authors presented a combined microscopic and endoscopic surgery and investigated its value in resecting pineal region meningiomas.

Methods: Twelve patients with pineal region meningiomas from February 2017 to December 2020 were retrospectively reviewed. Read More

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February 2022

Adenocarcinoma Arising in a Yolk Sac Tumor of the Pineal Gland.

J Neuropathol Exp Neurol 2022 03;81(4):291-295

Department of Neurosurgery, Columbia University Irving Medical Center, New York, New York, USA.

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Occipital Interhemispheric Transtentorial Approach for a Pineal Region Meningioma with Pseudobulbar Palsy.

World Neurosurg 2022 May 11;161:71. Epub 2022 Feb 11.

Department of Neurology, Psychology and Psychiatry, Division of Neurosurgery, Botucatu Medical School-UNESP São Paulo State University, Botucatu, São Paulo, Brazil.

Meningiomas represent 8%-10% of all pineal region (PR) tumors. When they arise from the falx, tentorium, or tentorial incisura, they are not always considered a true PR tumor, as they do not originate from it but instead only grow toward the region. The true meningioma of PR must be originated from the arachnoid envelope of the pineal gland or from the 2 leaflets of the velum interpositum. Read More

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Intracranial Germinoma Misdiagnosed as Hyperthyroidism: A Case Report and Review of the Literature.

Front Endocrinol (Lausanne) 2021 24;12:789109. Epub 2022 Jan 24.

Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu, China.

Intracranial germ cell tumors (GCTs) are relatively rare, which account for 0.5% of all primary intracranial neoplasms. Intracranial germinomas most commonly occur in the pineal and suprasellar region, making up the majority of all intracranial GCTs. Read More

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Two cases of pineal anlage tumor with molecular analysis.

Pediatr Blood Cancer 2022 04 7;69(4):e29596. Epub 2022 Feb 7.

Department of Laboratories, Seattle Children's Hospital, Seattle, Washington, USA.

Pineal anlage tumor is a rare pediatric tumor with clinical and histological features overlapping with pineoblastoma. Two patients with pineal anlage tumor, a 13-month-old female and an 11-month-old male, underwent subtotal resection, high-dose chemotherapy with autologous stem cell rescue, and radiation. Neither had tumor progression 50 months after diagnosis. Read More

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Multiple lessons learned from a single case: Complications from pineal germinoma management.

Surg Neurol Int 2022 20;13:29. Epub 2022 Jan 20.

Department of Neurosurgery King Abdullah Medical City, Makkah, Western Saudi Arabia.

Background: Pineal tumors are uncommon tumors that affect <1% of adults, with 50% of them being germinomas. A combination of endoscopic third ventriculostomy (ETV) and tumor biopsy is usually used. Cerebral vasospasm in association with aneurysmal subarachnoid hemorrhage (aSAH) has been extensively studied. Read More

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January 2022

Long term outcomes following surgery for pineal region tumors.

J Neurooncol 2022 Feb 27;156(3):491-498. Epub 2022 Jan 27.

Department of Neurosurgery, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX, 77030, USA.

Purpose: Pineal region tumors are surgically demanding tumors to resect. Long term neuro-oncologic outcomes following surgical excision of tumors from this region have been underreported. We sought to define the long term outcomes of patients undergoing resection of pineal region tumors. Read More

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February 2022

Epilepsy in Five Long-term Survivors of Pineal Region Tumors.

NMC Case Rep J 2021 2;8(1):773-780. Epub 2021 Nov 2.

Department of Epileptology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan.

Cognitive decline is a well-known chronic side effect of multidisciplinary treatment of pineal region tumors, whereas epilepsy is an under-reported chronic consequence caused by multiple potential factors including radiotherapy, surgery, or chemotherapy. Some long-term survivors have suffered drug-resistant epilepsy after treatment, which impaired the quality of life. We report five consecutive patients with drug-resistant epilepsy after combined treatment of pineal region tumor (5 men, aged 21-42 years) among 1201 epilepsy patients who underwent comprehensive evaluation in our tertiary epilepsy center from 2011 to 2018. Read More

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November 2021

A Case of Synchronous Occurrence of Intracranial Germinoma and Systemic Sarcoidosis.

NMC Case Rep J 2021 16;8(1):645-650. Epub 2021 Sep 16.

Department of Neurosurgery, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan.

Although the synchronous occurrence of testicular seminoma and systemic sarcoidosis has been reported, that of intracranial germinoma and systemic sarcoidosis is unknown. A 26-year-old man presented with symptoms of panhypopituitarism and consciousness disturbance. Imaging demonstrated a large nodule in the upper right lung field and swelling of multiple bilateral pulmonary and mediastinal lymph nodes in addition to the bifocal pineal and suprasellar tumors with obstructive hydrocephalus. Read More

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September 2021