3,062 results match your criteria Pineal Tumors

Multidisciplinary treatment of primary intracranial yolk sac tumor: A case report and literature review.

Medicine (Baltimore) 2021 May;100(19):e25778

Department of Radiation Oncology, Hebei General Hospital, Shijiazhuang.

Rationale: Intracranial yolk sac tumors (YSTs) are rare malignancies with limited treatment options and a dismal prognosis. They are usually managed with surgical resection and chemoradiotherapy.

Patient Concerns: Here, we report a patient with primary YST in the pineal region who achieved long term survival. Read More

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An Elderly Man Suffers a Renal Cell Carcinoma Metastasis in the Pineal Gland: Lessons Learned and Ethical Considerations.

Cureus 2021 Apr 30;13(4):e14771. Epub 2021 Apr 30.

Department of Neurosurgery, Imam Abdulrahman Bin Faisal University, King Fahd Hospital of the University, Khobar, SAU.

Metastases to the pineal gland are rare and reported cases have consisted mainly of lung and gastrointestinal primary malignancies. Here we report the third case in the literature of pineal gland metastasis from renal cell carcinoma. A 69-year-old man, status post excision of right renal cell carcinoma 20 years ago, presented with a one-month history of urinary incontinence. Read More

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The external metastasis of the central nerve system germ cell tumors: case report and review of the literature.

Chin Neurosurg J 2021 Jun 2;7(1):29. Epub 2021 Jun 2.

Department of Radiation Oncology, Beijing Tiantan Hospital, Capital Medical University, 119, South 4th Ring West Road, Fengtai District, Beijing, China.

Background: Central nervous system germ cell tumors (CNS GCTs) represent a class of rare tumors that exhibit region-specific prevalence in some Asian areas (15.3%), higher than that in North America (3.6%), and age-specific prevalence in children and adolescents. Read More

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Pineal anlage tumor: A case report and clinico-pathological review.

Clin Neurol Neurosurg 2021 Jul 5;206:106629. Epub 2021 May 5.

Department of Radiotherapy and Oncology, PGIMER, Chandigarh.

Pineal anlage tumor (PAT) is an extremely rare tumor of paediatric population. It is considered as a subtype of pineoblastoma having ectomesenchymal/ rhabdomyoblastic and cartilaginous differentiation. PAT is presumed to have an aggressive behaviour with propensity for craniospinal fluid (CSF) spread due to histologically resemblance with pineoblastoma, thus requiring intensive multimodality treatment with craniospinal irradiation and chemotherapy. Read More

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Pineal Region Hemangioblastoma Resection Through Paramedian Supracerebellar Approach: 2-Dimensional Operative Video.

Oper Neurosurg (Hagerstown) 2021 Jun;21(1):E34-E35

Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Pineal region tumors remain challenging lesions to safely resect because of their central location.1 Patients frequently present with symptoms associated with hydrocephalus and brainstem compression.2 Local anatomy, primarily the tentorium angle and venous anatomy, plays a central role in the selection of the approach. Read More

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Massive congenital immature teratoma of the lateral ventricle in a 33-day infant comorbidity with atrial septal defect.

Childs Nerv Syst 2021 May 11. Epub 2021 May 11.

Pediatric Neurosurgery, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, 200092, China.

Congenital teratomas are extremely rare and mainly midline tumors arising in the pineal regions in childhood brain tumors which are rarer cases occur in the lateral ventricle. Atrial septal defect (ASD) is detected in approximately 0.15% of newborns. Read More

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Part-time cancers and role of melatonin in determining their metabolic phenotype.

Life Sci 2021 Aug 8;278:119597. Epub 2021 May 8.

Departamento de Biologia Estrutural e Funcional, Instituto de Biociencias, Botucatu, Sao Poalo 18618-689, Brazil.

This brief review describes the association of the endogenous pineal melatonin rhythm with the metabolic flux of solid tumors, particularly breast cancer. It also summarizes new information on the potential mechanisms by which endogenously-produced or exogenously-administered melatonin impacts the metabolic phenotype of cancer cells. The evidence indicates that solid tumors may redirect their metabolic phenotype from the pathological Warburg-type metabolism during the day to the healthier mitochondrial oxidative phosphorylation on a nightly basis. Read More

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Pineal region tumours in the sitting position: how I do it.

Acta Neurochir (Wien) 2021 May 2. Epub 2021 May 2.

Victor Horsley Department of Neurosurgery, The National Hospital for Neurology and Neurosurgery, Queen Square, London, UK.

Background: Pineal region tumours remain challenging neurosurgical pathologies.

Methods: Detailed anatomical knowledge of the posterior incisural space and its variations is critical. An opaque arachnoidal membrane seals the internal cerebral and basal veins, leading to thalamic, basal ganglia, mesencephalic/pontine infarctions if injured. Read More

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Case Report: Metastatic Bronchopulmonary Carcinoid Tumor to the Pineal Region.

Front Endocrinol (Lausanne) 2021 31;12:623756. Epub 2021 Mar 31.

Department of Neurosurgery, Carilion Clinic Neurosurgery, Roanoke, VA, United States.

Intracranial spread of a systemic malignancy is common in advanced staged cancers; however, metastasis specifically to the pineal gland is a relatively rare occurrence. A number of primary lesions have been reported to metastasize to the pineal gland, the most common of which is lung. However, metastasis of a bronchial neuroendocrine tumor to the pineal gland is a seldom-reported entity. Read More

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Molecular classification of a complex structural rearrangement of the RB1 locus in an infant with sporadic, isolated, intracranial, sellar region retinoblastoma.

Acta Neuropathol Commun 2021 04 7;9(1):61. Epub 2021 Apr 7.

The Steve and Cindy Rasmussen Institute for Genomic Medicine, Abigail Wexner Research Institute At Nationwide Children's Hospital, 575 Children's Crossroad, Columbus, OH, 43215 , USA.

Retinoblastoma is a childhood cancer of the retina involving germline or somatic alterations of the RB Transcriptional Corepressor 1 gene, RB1. Rare cases of sellar-suprasellar region retinoblastoma without evidence of ocular or pineal tumors have been described. A nine-month-old male presented with a sellar-suprasellar region mass. Read More

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Prospective pilot study to explore the melatonin level in brain tumor patients undergoing radiotherapy.

Sleep Breath 2021 Apr 6. Epub 2021 Apr 6.

Radiation Oncology Department, Catalan Institute of Oncology (ICO), Badalona (Barcelona), Catalonia, Spain.

Purpose: Our aim was to assess if the radiotherapy dose decreased the melatonin levels as well as the quality of life and sleep in brain tumor patients.

Methods: We performed a follow-up study on melatonin levels in saliva and its urinary metabolite sulfatoxi-melatonine (STM) samples in patients with brain tumors treated with radiotherapy close to the pineal gland's area. We analyzed the cortisol, cortisone, and excrection of STM normalized by urinary creatinine. Read More

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PTEN R130Q Papillary Tumor of the Pineal Region (PTPR) with Chromosome 10 Loss Successfully Treated with Everolimus: A Case Report.

Curr Oncol 2021 Mar 20;28(2):1274-1279. Epub 2021 Mar 20.

Department of Pediatric Neurology, Faculty of Medicine, Lebanese University, Beirut P.O. Box 6573/14, Lebanon.

Papillary tumors of the pineal region (PTPR) can be observed among adults with poor prognosis and high recurrence rates. Standards of therapy involve total surgical excision along with radiation therapy, with no promising prospects for primary adjuvant chemotherapy, as long-term treatment options have not been explored. Chromosome 10 loss is characteristic of PTPR, and gene alterations are frequently encountered in a wide range of human cancers and may be treated with mTORC1 inhibitors such as everolimus. Read More

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Pineal Gland Tumors: A Review.

Cancers (Basel) 2021 Mar 27;13(7). Epub 2021 Mar 27.

Anatomy and Physiopathology Division, Department of Clinical and Experimental Sciences, University of Brescia, 25123 Brescia, Italy.

The pineal gland is a small, pinecone-shaped endocrine gland that participates in the biological rhythm regulation of vertebrates. The recognized major product of the pineal gland is melatonin-a multifunctional endogenous indoleamine. Accumulating evidence suggests that the pineal gland is important for preserving ideal health conditions in vertebrate. Read More

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Prenatal diagnosis of bilateral retinoblastomas by multimodality fetal imaging: case report and review of the literature.

Clin Imaging 2021 Mar 20;78:121-126. Epub 2021 Mar 20.

Phoenix Children's Hospital, Department of Radiology, United States of America; University of Arizona School of Medicine, Department of Child Health, United States of America; University of Arizona School of Medicine, Department of Radiology, United States of America; Mayo Clinic, Department of Radiology, United States of America; Creighton University, Department of Radiology, United States of America.

Retinoblastoma is the prototypic genetic tumor. Caused by mutations in the RB1 gene, retinoblastomas are heritable in 40% of the cases and, in such cases, tumors are bilateral in 80%, unilateral in 15%, and trilateral in 5% of the cases. Trilateral retinoblastoma is a term that describes bilateral retinoblastomas plus a midline suprasellar or pineal neuroectodermal tumor. Read More

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The Third Eye Sees Double: Cohort Study of Clinical Presentation, Histology, Surgical Approaches, and Ophthalmic Outcomes in Pineal Region Germ Cell Tumors.

World Neurosurg 2021 Jun 17;150:e482-e490. Epub 2021 Mar 17.

Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota, USA. Electronic address:

Background: Intracranial germ cell tumors (GCTs) predominantly occur in the adolescent and young adult population and are most frequently located at the pineal gland. Tumor masses in the pineal region may cause ophthalmic symptoms due to compression to the midbrain, frequently presenting with Parinaud syndrome and hydrocephalus due to aqueductal compression.

Methods: We conducted a single-institution cohort study of primary, pineal region GCTs to characterize the clinical presentation, as well as associated ophthalmic and hydrocephalus outcomes. Read More

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Endoscopic Third Ventriculostomy and Simultaneous Tumor Biopsy in Pineal Region Tumors using the "Single Burr Hole" Technique: An Analysis of 34 Cases.

Asian J Neurosurg 2020 Oct-Dec;15(4):976-982. Epub 2020 Oct 19.

Department of Neurosurgery, SGPGIMS, Lucknow, Uttar Pradesh, India.

Background: Pineal region tumors often present with hydrocephalus. Endoscopic third ventriculostomy (ETV) and simultaneous tumor biopsy remain a minimally invasive procedure offering both diagnostic and therapeutic advantages in the management of these tumors. However, different operative techniques have been described in the literature. Read More

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October 2020

Pineal region tumors: a complement with imaging nuances.

Childs Nerv Syst 2021 May 2;37(5):1419-1422. Epub 2021 Mar 2.

Department of Radiology, Antônio Pedro University Hospital, Federal Fluminense University, Rua Marquês de Paraná, 303, Centro, Niterói, RJ, 24070-035, Brazil.

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Clinical and molecular heterogeneity of pineal parenchymal tumors: a consensus study.

Acta Neuropathol 2021 05 22;141(5):771-785. Epub 2021 Feb 22.

Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN, USA.

Recent genomic studies have shed light on the biology and inter-tumoral heterogeneity underlying pineal parenchymal tumors, in particular pineoblastomas (PBs) and pineal parenchymal tumors of intermediate differentiation (PPTIDs). Previous reports, however, had modest sample sizes and lacked the power to integrate molecular and clinical findings. The different proposed molecular group structures also highlighted a need to reach consensus on a robust and relevant classification system. Read More

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Pineal Region Meningioma in a Very Young Child.

Pediatr Neurosurg 2021 17;56(1):73-78. Epub 2021 Feb 17.

Department of Neurosurgery, Postgraduate Institute of Medical Education & Research (PGIMER), Chandigarh, India.

Introduction: Meningiomas in childhood are infrequently seen. Furthermore, they are extremely rare at a pineal location with few reported cases above 5-years of age. We present a very young child with a large pineal region meningioma which mimicked the usually occurring pathologies at this site. Read More

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February 2021

[Treatment outcomes in patients with central nervous system germinoma (neuro-ophthalmic aspects)].

Zh Vopr Neirokhir Im N N Burdenko 2021 ;85(1):78-86

Burdenko Neurosurgery Center, Moscow, Russia.

Objective: The analyze the neuro-ophthalmic outcomes in patients with pineal and suprasellar germinoma after complex treatment.

Material And Methods: There were 125 patients (88 males, 37 females) with primary CNS germinoma for the period 2008-2017. All patients were divided into 3 groups depending on the tumor localization: pineal area - 62 patients, suprasellar neoplasm - 38 patients, bifocal germinoma - 25 patients. Read More

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February 2021

Epidemiological Profiling and Trends of Primary Intracranial Tumors: A Hospital-Based Brain Tumor Registry from a Tertiary Care Center.

J Neurosci Rural Pract 2021 Jan 29;12(1):145-152. Epub 2021 Jan 29.

Department of Pathology, SMS Medical College, Jaipur, Rajasthan, India.

 Hospital-based cancer registry is an essential tool for augmentation of the standard of care, administration motive, and resource for population-based cancer registries. Here, we presented hospital-based brain tumor registry (HBBTR) to outline a comprehensive epidemiological data, both clinical and histopathological, as well as trends of central nervous system tumors. In addition, we compare this data with national brain tumor data as well as an international brain tumor registry. Read More

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January 2021

Management of Obstructive Hydrocephalus Associated with Pineal Region Cysts and Tumors and Its Implication in Long-Term Outcome.

World Neurosurg 2021 May 28;149:e913-e923. Epub 2021 Jan 28.

"Juha Hernesniemi" International Center for Neurosurgery, Henan Provincial People's Hospital, Zhengzhou, China.

Background: Different treatment options have been proposed for obstructive hydrocephalus associated with pineal lesions. We discuss the obstructive hydrocephalus management associated with pineal region tumors and cysts in Helsinki Neurosurgery.

Methods: In this article, hydrocephalus treatment by tumor-cyst removal (n = 40), shunt surgery (n = 25), and endoscopic ventriculostomies (n = 3) is evaluated in 68 patients with obstructive hydrocephalus among 136 patients with pineal region tumor and cyst. Read More

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Multimodality treatment for Central Nervous System Germ Cell Tumors: Disease spectrum and management strategies - A tertiary care center experience from India.

Clin Neurol Neurosurg 2021 Mar 13;202:106481. Epub 2021 Jan 13.

Department of Radiotherapy & Oncology, PGIMER, Chandigarh, India. Electronic address:

Objective: Intracranial germ cell tumors (GCTs) are relatively rare neoplasms, representing 2-3 % of paediatric brain tumors in Western countries and 8-15 % in East Asia. Here, we discuss the clinical features and treatment outcomes in patients with central nervous system (CNS) GCTs treated at our institute.

Methods: Medical records of all primary CNS GCT patients were retrieved retrospectively from 2007 to 2019. Read More

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Characterization of high-grade pineal region lesions: the usefulness of apparent diffusion coefficient volumetric values.

Acta Radiol 2021 Jan 26:284185120986912. Epub 2021 Jan 26.

Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Roma-UOC Radiologia e Neuroradiologia, Polo Diagnostica per immagini, radioterapia, oncologia ed ematologia, Area diagnostica per immagini, Rome, Italy.

Background: High-grade pineal region tumors are rare and heterogeneous types of primary central nervous system neoplasms; radiological differential diagnosis is challenging but it is important because it has a therapeutic relevance.

Purpose: To discriminate among high-grade pineal region tumors by combining apparent diffusion coefficient (ADC) volumetric values and qualitative features in order to predict their histology.

Material And Methods: Twenty-two patients with high-grade pineal region tumors were assessed by qualitative and quantitative analysis. Read More

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January 2021

Cytologic Features of Ventricular Tumors of the Central Nervous System: A Review with Emphasis on Diff-Quik Stained Smears.

Acta Cytol 2021 21;65(2):111-122. Epub 2021 Jan 21.

Department of Pathology, University Hospital Doce de Octubre, Madrid, Spain.

Background: Neoplasms from the ventricular system share a common location but have highly variable histogenesis. Many are slowly growing tumors that behave in a benign fashion. They can be classified as primary and secondary tumors. Read More

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Mission impossible: chemotherapy in the intensive care for pineal region germ cell tumor.

Childs Nerv Syst 2021 Jan 20. Epub 2021 Jan 20.

Department of Neurosurgery, All India Institute of Medical Sciences, New Delhi, India.

Pineal region tumors are rare and a heterogenous group of primary central nervous system tumors which are primarily classified as germ cell tumors and non-germ cell tumors. Chemotherapy and radiotherapy as the primary treatment modalities have been reported to result in good outcomes. We discuss the case of a young girl who presented to our emergency department in an unconscious state and had a large lesion in the posterior third ventricular region, but without any associated hydrocephalus which could explain her stuporous state. Read More

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January 2021

Incidental Findings on Brain Magnetic Resonance Imaging (MRI) in Pediatric Endocrine Patients.

Endocr Pract 2020 Oct;26(10):1105-1114

From the Pediatric Endocrinology and Diabetes Unit, Tel-Aviv, Israel.

Objective: To explore incidental findings on brain magnetic resonance imaging (MRI) studies of pediatric patients referred due to endocrine disorders.

Methods: A retrospective, observational study conducted in a tertiary referral center. The neuroimaging database of 17,445 brain MRI studies of 11,011 pediatric patients were searched for cases with endocrine referrals and without medical history of malignancy, genetic syndromes, and/or neurologic comorbidities. Read More

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October 2020

Rhinitis as the Presenting Symptom of Pineal Region Epidermoid Tumor: A Case Report.

Iran J Allergy Asthma Immunol 2020 Aug 25;19(4):452-455. Epub 2020 Aug 25.

Department of Immunology and Allergy, Allergy Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Brain tumors are the rarest cause of cerebrospinal fluid rhinorrhea. Non-traumatic cerebrospinal fluid rhinorrhea is also a relatively rare condition. It may be misdiagnosed as allergic rhinitis or chronic sinusitis and lead to unsuitable treatment. Read More

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Desmoplastic myxoid tumor, SMARCB1-mutant: a new variant of SMARCB1-deficient tumor of the central nervous system preferentially arising in the pineal region.

Virchows Arch 2021 Jan 9. Epub 2021 Jan 9.

Department of Human Pathology, Gunma University Graduate School of Medicine, 3-39-22, Showa-machi, Maebashi, Gunma, 371-8511, Japan.

Desmoplastic myxoid tumor (DMT), SMARCB1-mutant is a recently proposed brain tumor that occurs in the pineal region of adults. This tumor is characterized by desmoplastic stroma and various degrees of myxoid matrix. Tumor cells with low-grade morphology show polyphenotypic immunoreactivity, and rhabdoid cells are rare. Read More

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January 2021

Potential Importance of Early Focal Radiotherapy Following Gross Total Resection for Long-Term Survival in Children With Embryonal Tumors With Multilayered Rosettes.

Front Oncol 2020 17;10:584681. Epub 2020 Dec 17.

Department of Pediatrics and Adolescent Medicine and Comprehensive Center for Pediatrics, Medical University of Vienna, Vienna, Austria.

Embryonal tumor with multilayered rosettes (ETMR) is a rare, aggressive embryonal central nervous system tumor characterized by LIN28A expression and alterations in the locus. ETMRs predominantly occur in young children, have a dismal prognosis, and no definitive treatment guidelines have been established. We report on nine consecutive patients and review the role of initiation/timing of radiotherapy on survival. Read More

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December 2020