2,854 results match your criteria Pineal Tumors


Bifocal germinoma in a patient with 16p11.2 microdeletion syndrome.

Endocrinol Diabetes Metab Case Rep 2019 Feb 7;2019. Epub 2019 Feb 7.

Department of Endocrinology, Diabetes and Metabolism.

Intracranial germinomas are rare tumors affecting mostly patients at young age. Therefore, molecular data on its etiopathogenesis are scarce. We present a clinical case of a male patient of 25 years with an intracranial germinoma and a 16p11. Read More

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http://dx.doi.org/10.1530/EDM-18-0149DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373620PMC
February 2019
10 Reads

Unedited microneurosurgery of a mixed germ cell tumor of the pineal region.

Surg Neurol Int 2018 24;9:262. Epub 2018 Dec 24.

International Center for Neurosurgery, Henan Provincial People's Hospital, Zhengzhou, China.

Background: Germ cell tumors comprise a heterogeneous group of neoplasms, classified as germinomas and nongerminomatous germ cell tumors based on clinicopathological features. The nongerminomatous group of tumors includes embryonal carcinoma, endodermal sinus tumor (yolk sac tumor), choriocarcinoma, mature and immature teratoma, and mixed germ cell tumors with more than one element. While germinomas are radiation-sensitive tumors, all other tumors have less response to radiotherapy, and it is suggested that gross total resection improves their overall survival and tumor-free survival rates. Read More

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http://dx.doi.org/10.4103/sni.sni_357_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322164PMC
December 2018
1 Read

Unedited microneurosurgery of a pineal region ependymoma.

Surg Neurol Int 2018 24;9:260. Epub 2018 Dec 24.

International Center for Neurosurgery, Henan Provincial People's Hospital, Zhengzhou, China.

Background: Ependymomas are rarely located in the pineal region. The 2016 WHO classification of tumors of the central nervous system includes five ependymal tumors, the grade I subependymoma and mixopapillary ependymoma, the grade II ependymoma, the grade II-III ependymoma RELA fusion-positive, and the grade III anaplastic ependymoma. However, this grading system has been controversial with respect to its reproducibility and clinical significance and it is estimated that further studies of the molecular characteristics of ependymoma will provide more precise and objective classification. Read More

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http://dx.doi.org/10.4103/sni.sni_355_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322167PMC
December 2018

Pan-cancer genomic analyses reveal prognostic and immunogenic features of the tumor melatonergic microenvironment across 14 solid cancer types.

J Pineal Res 2019 Jan 14:e12557. Epub 2019 Jan 14.

Department of Radiation Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, China.

We performed comprehensive genomic analyses of the melatonergic system within the tumor microenvironment and their clinical relevance across a broad spectrum of solid tumors. RNA-seq data from The Cancer Genome Atlas (TCGA) of 14 solid tumors representing 6658 human samples were analyzed. The tumor melatonergic system was characterized by the rates of melatonin synthesis and metabolism using a two-gene expression model (melatonin synthesis/metabolism Index). Read More

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http://doi.wiley.com/10.1111/jpi.12557
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http://dx.doi.org/10.1111/jpi.12557DOI Listing
January 2019
11 Reads

Potential use of melatonin in skin cancer treatment: A review of current biological evidence.

J Cell Physiol 2019 Jan 7. Epub 2019 Jan 7.

Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, I. R. Iran.

Skin cancer, particularly melanoma, is a leading cause of death worldwide. The therapeutic methods for this malignancy are not effective, and due to the side effects of these treatments, applying an appropriate alternative or complementary treatment is important. According to available data, melatonin as the main product of the pineal gland has oncostatic and antitumoral properties. Read More

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http://dx.doi.org/10.1002/jcp.28129DOI Listing
January 2019
2 Reads

Sodium fluorescein-guided brain tumor surgery under the YELLOW-560-nm surgical microscope filter in pediatric age group: feasibility and preliminary results.

Childs Nerv Syst 2019 Mar 4;35(3):429-435. Epub 2019 Jan 4.

Department of Neurosurgery, Liv Hospital Ulus, Istanbul, Turkey.

Objective: To evaluate the feasibility and safety of sodium fluorescein (Na-Fl)-guided surgery with the use of the PENTERO 900 surgical microscope (Carl Zeiss, Meditec, Oberkochen, Germany) equipped with the YELLOW-560-nm filter and low-dose Na-Fl (2 mg/kg) in pediatric brain tumor surgery.

Methods: The study included 23 pediatric patients with various intracranial pathologies, who underwent Na-Fl-guided surgery between April 2015 and February 2018. Clinical features, surgical observations, extent of resection, and tumor histopathology were retrospectively analyzed. Read More

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http://dx.doi.org/10.1007/s00381-018-04037-4DOI Listing
March 2019
1 Read

Unedited microneurosurgery of a high-grade pineal parenchymal tumor of intermediate differentiation.

Surg Neurol Int 2018 4;9:248. Epub 2018 Dec 4.

International Center for Neurosurgery, Henan Provincial, People's Hospital, Zhengzhou, China.

Background: WHO Grade II-III pineal parenchymal tumors of intermediate differentiation (PPTIDs) were included in the 2007 World Health Organization Classification of Central Nervous System Tumors as pineal parenchymal tumors between pineocytomas and pineoblastomas. PPTIDs comprise more than 20-60% of all pineal parenchymal tumors (PPT) s and are characterized by moderately high cellularity, mild-to-moderate nuclear atypia, and low-to-moderate mitotic activity. Moreover, PPTID includes transitional cases in which pineocytomatous and pineoblastoma features are associated. Read More

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http://surgicalneurologyint.com/surgicalint-articles/unedite
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http://dx.doi.org/10.4103/sni.sni_353_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6293592PMC
December 2018
6 Reads

Unedited microneurosurgery of a solitary fibrous tumor of the pineal region.

Surg Neurol Int 2018 28;9:232. Epub 2018 Nov 28.

International Center for Neurosurgery, Henan Provincial People's Hospital, Zhengzhou, China.

Background: Solitary fibrous tumor/hemangiopericytoma is a new combined entity introduced in the 2016 World Health Organization classification of tumors of the central nervous system for grade I-III soft-tissue tumors. While grades II and III present more aggressive course and might require adjuvant radiochemotherapy, grade I tumors have a good outcome after gross total resection. In this video-abstract, we present an unedited microneurosurgery of a histologically confirmed benign solitary fibrous tumor of the pineal region performed by a senior author (JH). Read More

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http://dx.doi.org/10.4103/sni.sni_264_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287330PMC
November 2018

Meningiomas Originated at the Falcotentorial Region: Analysis of Topographic and Diagnostic Features Guiding an Optimal Surgical Planning.

World Neurosurg 2018 Dec 21. Epub 2018 Dec 21.

Department of Neurosurgery, Department of Surgery, University Hospital La Princesa, Madrid, Spain.

Background: Meningiomas arising at the pineal region are a rare entity and still represent a great neurosurgical challenge given their deep location and critical neuroanatomic relationships. The optimal surgical approach to treat these lesions is still under debate. Our objective is to review the topographic and diagnostic features of these lesions, which can help to guide an optimal surgical outcome. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.12.013DOI Listing
December 2018

Melatonin restricts the viability and angiogenesis of vascular endothelial cells by suppressing HIF-1α/ROS/VEGF.

Int J Mol Med 2019 Feb 10;43(2):945-955. Epub 2018 Dec 10.

Laboratory for Reproductive Immunology, Key Laboratory of Reproduction Regulation of NPFPC, SIPPR, IRD, Hospital of Obstetrics and Gynecology, Fudan University Shanghai Medical College, Shanghai 200011, P.R. China.

Angiogenesis is an essential process involved in various physiological, including placentation, and pathological, including cancer and endometriosis, processes. Melatonin (MLT), a well‑known natural hormone secreted primarily in the pineal gland, is involved in regulating neoangiogenesis and inhibiting the development of a variety of cancer types, including lung and breast cancer. However, the specific mechanism of its anti‑angiogenesis activity has not been systematically elucidated. Read More

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http://dx.doi.org/10.3892/ijmm.2018.4021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317691PMC
February 2019
1 Read

Third Ventricular Tumors: A Comprehensive Literature Review.

Cureus 2018 Oct 5;10(10):e3417. Epub 2018 Oct 5.

Internal Medicine, Icahn School of Medicine at Mount Sinai/Queens Hospital Center, New York, USA.

Third ventricle tumors are uncommon and account for 0.6 - 0.9% of all the brain tumors. Read More

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http://dx.doi.org/10.7759/cureus.3417DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284874PMC
October 2018
27 Reads

The Supra/Infra Transtentorial Transfalcine Approach for the Removal of a Falcotentorial Meningioma: 2-Dimensional Video.

Oper Neurosurg (Hagerstown) 2018 Nov 28. Epub 2018 Nov 28.

Director of Skull Base Program, Department of Neurological Surgery, Centro Médico Nacional 20 de Noviembre, ISSSTE, Mexico City, Mexico.

Falcotentorial meningiomas originate in the junction of the falx cerebri and the tentorium. Due to its anatomic vicinity, these tumors have a close relationship with important neurovascular structures surrounding the pineal region including the deep venous system. Surgical approaches would normally consider posterior midline corridors, but decision between supra or infratentorial access should be considered by the size, anatomic displacement of structures, and the infiltration of the dural attachment. Read More

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http://dx.doi.org/10.1093/ons/opy353DOI Listing
November 2018
2 Reads

Clinical Management of Prostate Cancer Metastasis to Pineal Gland: Case Report and Review of Literature.

World Neurosurg 2019 Feb 24;122:464-468. Epub 2018 Nov 24.

Department of Neurological Surgery, George Washington University, Washington, D.C., USA. Electronic address:

Background: Prostate cancer is the most common cancer among American men, with an incidence of approximately 233,000 cases per year. Intracranial metastases are rare and, specifically, metastasis to the pineal gland has only been reported in 2 postmortem cases in the literature.

Case Description: We present the first documented case of confirmed prostate cancer metastasis to the pineal gland in a living patient. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.11.111DOI Listing
February 2019
2 Reads

Fast-developing fatal diffuse leptomeningeal dissemination of a pineal germinoma in a young child: a case report and literature review.

Br J Neurosurg 2018 Nov 19:1-8. Epub 2018 Nov 19.

a Department of Neurosurgery , West China Hospital, Sichuan University , Chengdu , Sichuan 610041 , China.

Background: Intracranial germinomas are uncommon and constitute less than 1% of all intracranial tumors. They usually arise in the midline of the brain, most commonly in the pineal region. Pineal germinomas tend to spread through the cerebrospinal fluid (CSF). Read More

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https://www.tandfonline.com/doi/full/10.1080/02688697.2018.1
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http://dx.doi.org/10.1080/02688697.2018.1520804DOI Listing
November 2018
13 Reads

[Parinaud syndrome caused by corpus pineale tumour in a 14-year-old boy].

Ugeskr Laeger 2018 Nov;180(46)

Parinaud syndrome (PS) can manifest in a pineal tumour. Major components of PS include restriction of gazing upwards, light-near dissociation and convergence retraction nystagmus. A 14-year-old boy presented with diplopia and restricted ability to gaze upwards. Read More

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November 2018
2 Reads

Pineal Parenchymal Tumors of Intermediate Differentiation: A long-Term Follow-Up Study in Helsinki Neurosurgery.

World Neurosurg 2019 Feb 1;122:e729-e739. Epub 2018 Nov 1.

"Juha Hernesniemi" International Center for Neurosurgery, Henan Provincial Peoplés Hospital, Zhengzhou, People's Republic of China.

Background: Pineal parenchymal tumors of intermediate differentiation (PPTIDs) are rare lesions with particular features compared with other pineal parenchymal tumors.

Methods: We present a retrospective review of patients with histologically confirmed PPTIDs who were operated on in our department between 1997 and 2015. A demographic analysis and an evaluation of preoperative status, surgical treatment, as well as immediate and long-term clinical and radiologic outcomes were conducted. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18788750183242
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http://dx.doi.org/10.1016/j.wneu.2018.10.128DOI Listing
February 2019
6 Reads
2.420 Impact Factor

Melatonin: An Anti-Tumor Agent in Hormone-Dependent Cancers.

Int J Endocrinol 2018 2;2018:3271948. Epub 2018 Oct 2.

Department of Physiology and Pharmacology, School of Medicine, University of Cantabria and Instituto de Investigación Valdecilla (IDIVAL), 39011 Santander, Spain.

Melatonin (N-acetyl-5-methoxytryptamine) is a hormone synthesized and secreted by the pineal gland mainly during the night, since light exposure suppresses its production. Initially, an implication of this indoleamine in malignant disease was described in endocrine-responsive breast cancer. Data from several clinical trials and multiple experimental studies performed both and have documented that the pineal hormone inhibits endocrine-dependent mammary tumors by interfering with the estrogen signaling-mediated transcription, therefore behaving as a selective estrogen receptor modulator (SERM). Read More

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https://www.hindawi.com/journals/ije/2018/3271948/
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http://dx.doi.org/10.1155/2018/3271948DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6189685PMC
October 2018
3 Reads

Pineal and Suprasellar Germinoma Cooccurence with Vertebra Plana: A Case Report.

Brain Tumor Res Treat 2018 Oct;6(2):73-77

Department of Neurosurgery, Mashhad University of Medical Sciences, Mashhad, Iran.

Germinoma is the most common type of intracranial germ cell tumors (GCTs). Pineal gland and suprasellar region are the most frequent sites of central nervous system (CNS) involvement. Intracranial masses caused by Langerhans cell histiocytosis (LCH) mimics features of CNS GCTs. Read More

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https://synapse.koreamed.org/DOIx.php?id=10.14791/btrt.2018.
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http://dx.doi.org/10.14791/btrt.2018.6.e9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6212690PMC
October 2018
5 Reads

Clinical case seminar: Familial intracranial germinoma.

Endokrynol Pol 2018 ;69(5):612-618

Clinic for Endocrinology, Diabetes and Metabolic Diseases, Clinical Centre of Serbia, Belgrade, Serbia, Serbia and Montenegro; University of Belgrade, School of Medicine, Belgrade, Serbia.

Background: Intracranial germinomas (ICG) are uncommon brain neoplasms with extremely rare familial occurance. Since ICG invades hypothalamus and/or pituitary, the endocrine dysfunction is one of the common determinants of these tumors. We presented two brothers with the history of ICG. Read More

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https://journals.viamedica.pl/endokrynologia_polska/article/
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http://dx.doi.org/10.5603/EP.2018.0060DOI Listing
January 2018
16 Reads

[Parinaud syndrome caused by corpus pineale tumour in a 14-year-old boy].

Ugeskr Laeger 2018 Oct;180(43)

Parinaud syndrome (PS) can manifest in a pineal tumour. Major components of PS include restriction of gazing upwards, light-near dissociation and convergence retraction nystagmus. A 14-year-old boy presented with diplopia and restricted ability to gaze upwards. Read More

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October 2018
2 Reads

Primary Intracranial Manifestation of a Carcinosarcoma.

Asian J Neurosurg 2018 Jul-Sep;13(3):923-927

Department of Neuropathology, Saarland University Medical Center and Saarland University Faculty of Medicine, Homburg/Saar, Germany.

Carcinosarcomas are tumors comprising part adenocarcinoma and part sarcoma; the presence of carcinosarcoma in the head-and-neck region is very rare. These tumors are typically highly aggressive (G3) and arise most frequently from the salivary gland. Here, we present a case report on a brain metastasis as the primary manifestation of a carcinosarcoma. Read More

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http://dx.doi.org/10.4103/ajns.AJNS_19_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6159043PMC
October 2018
2 Reads

Primary Central Nervous System Germ Cell Tumors: A Review and Update.

Med Res Arch 2018 Mar 15;6(3). Epub 2018 Mar 15.

Department of Neurosurgery, Indiana University School of Medicine, IUPUI, Indiana, USA.

Importance: Primary central nervous system (CNS) germ cell tumors (GCT) are a heterogeneous group of tumors that are still poorly understood. In North America, GCTs comprise approximately 1% of primary brain tumors in pediatric and young adult patients. GCTs can occur as pure or mixed subtypes; they are divided into germinomas, which are the most common subtype, and non-germinomatous germ cell tumors (NGGCTs), which consist of approximately one-third of GCTs and include teratomas, embryonal carcinomas, choriocarcinomas, and yolk sac tumors. Read More

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http://dx.doi.org/10.18103/mra.v6i3.1719DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6157918PMC
March 2018
14 Reads

Placental alkaline phosphatase levels in cerebrospinal fluid can have a decisive role in the differential diagnosis of intracranial germ cell tumors.

J Neurosurg 2018 Sep 1:1-8. Epub 2018 Sep 1.

1Department of Neurosurgery, Tokyo Women's Medical University, Tokyo.

OBJECTIVEPlacental alkaline phosphatase (PLAP) in CSF can provide a very high diagnostic value in cases of intracranial germ cell tumors (GCTs), especially in pure germinomas, to the level of not requiring histological confirmation. Unlike other tumor markers, reliable data analysis with respect to the diagnostic value of PLAP serum or CSF levels has not been available until now. This is the first systematic and comprehensive study examining the diagnostic value of CSF PLAP in patients with intracranial GCTs. Read More

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http://thejns.org/doi/10.3171/2018.3.JNS172520
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http://dx.doi.org/10.3171/2018.3.JNS172520DOI Listing
September 2018
15 Reads

Renin-producing germ cell tumor in the pineal apparatus and mediastinum: A rare case report.

J Cancer Res Ther 2018 Sep;14(Supplement):S806-S808

Department of Pulmonary Medicine, Fukushima Medical University School of Medicine, Fukushima 960-1295, Japan.

Ectopic extrarenal renin-producing tumor is a rare disease with approximately 30 case reports in English literature. We herein present the first case of renin-producing germ cell tumors in the pineal apparatus and mediastinum. A 26-year-old man who had undergone craniotomy for the treatment of pineal tumor was found to have hypertension at a regular visit postoperatively. Read More

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http://dx.doi.org/10.4103/0973-1482.180682DOI Listing
September 2018
2 Reads

Melatonin Can Strengthen the Effect of Retinoic Acid in HL-60 Cells.

Int J Mol Sci 2018 Sep 21;19(10). Epub 2018 Sep 21.

Institute of Theoretical and Experimental Biophysics, Russian Academy of Science, Institutskaya St, 3, 142290 Pushchino, Moscow region, Russia.

Melatonin is produced by the pineal gland. It can be regarded as an anticancer agent and used for combined therapy, owing to its oncostatic, antioxidant, and immunoregulatory activities. Retinoic acid is widely used for the treatment of acute promyelocytic leukemia; however, it has adverse effects on the human organism. Read More

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http://www.mdpi.com/1422-0067/19/10/2873
Publisher Site
http://dx.doi.org/10.3390/ijms19102873DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213950PMC
September 2018
4 Reads

Pineoblastoma in a child with 22q11.2 deletion syndrome.

BMJ Case Rep 2018 Sep 14;2018. Epub 2018 Sep 14.

Department of Neurosciences and Pediatrics, University of California San Diego, San Diego, California, USA.

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http://casereports.bmj.com/lookup/doi/10.1136/bcr-2018-22643
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http://dx.doi.org/10.1136/bcr-2018-226434DOI Listing
September 2018
12 Reads

One burr-hole craniotomy: Supracerebellar infratentorial paramedian approach in Helsinki Neurosurgery.

Surg Neurol Int 2018 14;9:162. Epub 2018 Aug 14.

International Center for Neurosurgery, Henan Provincial People's Hospital, Zhengzhou, China.

Background: In this video abstract, we present a one burr-hole craniotomy for the standard supracerebellar infratentorial (SCIT) paramedian approach developed in Helsinki Neurosurgery for the microsurgical management of pineal region lesions, tentorial meningiomas, as well as arteriovenous malformations, aneurysms, and intrinsic tumors of the superior surface of the cerebellum. In this regard, the use of praying sitting position in Helsinki Neurosurgery, which is a more ergonomic variant of the classic sitting position, offers several advantages such as lower intracranial pressure, good venous outflow, gravitational retraction, and straight anatomical orientation.

Case Description: The patient is placed in sitting praying position. Read More

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http://dx.doi.org/10.4103/sni.sni_164_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6108167PMC
August 2018
3 Reads

Mature teratoma of the pineal region in the paediatric age group: A case report and review of the literature.

Malays J Pathol 2018 Aug;40(2):175-183

University of the East Ramon Magsaysay Memorial Medical Center, Department of Pathology & Pathology Laboratory, Philippines.

Introduction: Intracranial teratomas account for 0.5% of all intracranial tumours and 2-4% of intracranial tumours in children. However, in terms of tumours of the pineal area, the exact incidence is not ascertained. Read More

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Multiple Cavernous Malformations of Brain, Chest, and Skin: A Rare Case of an Infant and Literature Review.

World Neurosurg 2018 Dec 29;120:177-180. Epub 2018 Aug 29.

Department of Neurosurgery, Guangzhou Women and Children's Medical Center, Guangzhou, China. Electronic address:

Background: Cerebral cavernous malformations (CCMs) are vascular malformations that account for 5%-15% of all central nervous system vascular malformations. However, multiple CCMs, which can be sporadic or familial, are rare, with a prevalence of 0.1%-0. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.08.152DOI Listing
December 2018
4 Reads

Recurrent Pineocytomalike Papillary Tumor of The Pineal Region: A Case Report and Literature Review.

World Neurosurg 2018 Dec 27;120:1-14. Epub 2018 Aug 27.

Department of Pathology, Chair of Oncology, Medical University of Lodz, Lodz, Poland.

Background: Papillary tumors of the pineal region (PTPRs) are malignant World Health Organization grade II/III tumors; however, they may perfectly mimic benign tumors (e.g., pineocytomas [World Health Organization grade I]). Read More

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http://dx.doi.org/10.1016/j.wneu.2018.08.125DOI Listing
December 2018
7 Reads

Rapid discrimination of pediatric brain tumors by mass spectrometry imaging.

J Neurooncol 2018 Nov 20;140(2):269-279. Epub 2018 Aug 20.

Winship Cancer Institute, Emory University School of Medicine, 1365C Clifton Road, Suite C5086, Atlanta, GA, 30322, USA.

Purpose: Medulloblastoma, the most common primary pediatric malignant brain tumor, originates in the posterior fossa of the brain. Pineoblastoma, which originates within the pineal gland, is a rarer malignancy that also presents in the pediatric population. Medulloblastoma and pineoblastoma exhibit overlapping clinical features and have similar histopathological characteristics. Read More

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http://dx.doi.org/10.1007/s11060-018-2978-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6244779PMC
November 2018
3 Reads

Midline Posterior Fossa Mature Teratoma in a Child.

J Pediatr Neurosci 2018 Apr-Jun;13(2):252-254

Department of Neurosurgery, Bansal Hospital, Bhopal, Madhya Pradesh, India.

Teratomas are germ cell tumors commonly composed of cell types derived from all of the three germ layers. Intracerebral teratomas typically present in midline or paraxial lesions located in the pituitary stalk or the pineal region. Teratoma in posterior fossa is a rare entity. Read More

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http://dx.doi.org/10.4103/jpn.JPN_5_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6057187PMC

Prognosis of Pediatric Patients with Pineoblastoma: A SEER Analysis 1990-2013.

World Neurosurg 2018 Oct 18;118:e871-e879. Epub 2018 Jul 18.

Department of Neurosurgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China. Electronic address:

Background: Pineoblastomas are rare, malignant embryonal tumors that have a relatively higher incidence and a poorer prognosis in children. Owing to the rarity of these tumors, there is a paucity of data on associated prognostic factors. We used the Surveillance, Epidemiology, and End Results (SEER) database to evaluate prognostic factors for pineoblastomas with the aim of improving tumor management. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.07.079DOI Listing
October 2018

Recurrent homozygous deletion of DROSHA and microduplication of PDE4DIP in pineoblastoma.

Nat Commun 2018 07 20;9(1):2868. Epub 2018 Jul 20.

Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, 10065, NY, USA.

Pineoblastoma is a rare and highly aggressive brain cancer of childhood, histologically belonging to the spectrum of primitive neuroectodermal tumors. Patients with germline mutations in DICER1, a ribonuclease involved in microRNA processing, have increased risk of pineoblastoma, but genetic drivers of sporadic pineoblastoma remain unknown. Here, we analyzed pediatric and adult pineoblastoma samples (n = 23) using a combination of genome-wide DNA methylation profiling and whole-exome sequencing or whole-genome sequencing. Read More

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http://dx.doi.org/10.1038/s41467-018-05029-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6054684PMC
July 2018
7 Reads

Flexible Neuroendoscopic Diagnosis and Management of Ventricular Tumors: A Retrospective Cohort Study.

World Neurosurg 2018 Oct 7;118:e707-e712. Epub 2018 Aug 7.

Departamento de Neurocirugía, Hospital Central Dr. Ignacio Morones Prieto, Facultad de Medicina de la Universidad Autónoma de San Luis Potosí, San Luis Potosí, México.

Background: Ventricular tumors (VTs) represent approximately 10% of intracranial lesions and are associated with hydrocephalus in 73.9%-100% of patients. We present our experience using flexible neuroendoscopy as a diagnostic and hydrocephalus-related treatment strategy for paraventricular and intraventricular tumors. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18788750183150
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http://dx.doi.org/10.1016/j.wneu.2018.07.023DOI Listing
October 2018
16 Reads

Malignant tumors in autoimmune encephalitis with anti-NMDA receptor antibodies.

J Neurol 2018 Jul 12. Epub 2018 Jul 12.

French Reference Center for Paraneoplastic Neurological Syndrome, Hospices Civils de Lyon, Hôpital Neurologique, 69677, Bron, France.

Objective: The aim of this study was to describe specificities of patients with NMDA receptor antibody (NMDAR-Ab) encephalitis associated with a malignant tumor.

Methods: Retrospective observational study of 252 patients with NMDAR-Ab encephalitis of the French Paraneoplastic Neurological Syndrome Reference Center. Patients were classified in three groups: (1) non-malignant ovarian teratomas, (2) malignant ovarian teratomas (immature), and (3) other malignant tumors. Read More

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http://link.springer.com/10.1007/s00415-018-8970-0
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http://dx.doi.org/10.1007/s00415-018-8970-0DOI Listing
July 2018
10 Reads

Pineal region glioblastomas display features of diffuse midline and non-midline gliomas.

J Neurooncol 2018 Oct 10;140(1):63-73. Epub 2018 Jul 10.

Department of Neurological Surgery, Columbia University Medical Center, New York, NY, USA.

Introduction: Pineal region glioblastomas (GBM) are very rare, with approximately 46 cases described in the literature. The epidemiology, pathogenesis, and treatment of these lesions are poorly characterized.

Methods: We identified all cases of pineal region GBM treated surgically at our institution between 1990 and 2017. Read More

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http://dx.doi.org/10.1007/s11060-018-2931-4DOI Listing
October 2018
14 Reads

Melatonin restrains angiogenic factors in triple-negative breast cancer by targeting miR-152-3p: In vivo and in vitro studies.

Life Sci 2018 Sep 7;208:131-138. Epub 2018 Jul 7.

Graduate Program in Health Science, Faculdade de Medicina de Sao Jose do Rio Preto - FAMERP, Sao Jose do Rio Preto, SP, Brazil; Graduate Program in Biosciences, Universidade Paulista-UNESP/IBILCE, Sao Jose do Rio Preto, SP, Brazil; Laboratory of Molecular Research in Cancer - LIMC, Faculdade de Medicina de Sao Jose do Rio Preto - FAMERP, Sao Jose do Rio Preto, SP, Brazil. Electronic address:

Aims: Breast cancer represents the second most prevalent tumor-related cause of death among women. Although studies have already been published regarding the association between breast tumors and miRNAs, this field remains unclear. MicroRNAs (miRNAs) are defined as non-coding RNA molecules, and are known to be involved in cell pathways through the regulation of gene expression. Read More

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http://dx.doi.org/10.1016/j.lfs.2018.07.012DOI Listing
September 2018
19 Reads

Modified Pure Endoscopic Approach to Pineal Region: Proof of Concept of Efficient and Inexpensive Surgical Model Based on Laboratory Dissections.

World Neurosurg 2018 Sep 20;117:195-198. Epub 2018 Jun 20.

Department of Neurosurgery, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.

Objective: In recent decades endoscopic techniques have been increasingly used in neurosurgery as they may offer a valuable close-up view of the working area through a minimally invasive surgical corridor. Herein, we present an inexpensive and efficient endoscopic surgical model using a borescope, which was used for a "modified pure endoscopic approach" to the pineal region.

Methods: A borescope video camera was connected to a 16-inch personal computer monitor. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.06.080DOI Listing
September 2018
4 Reads
2.420 Impact Factor

[Preoperative and postoperative ophthalmic symptoms in patients with space-occupying lesions of the midbrain and pineal region].

Zh Vopr Neirokhir Im N N Burdenko 2018 ;82(3):42-47

Burdenko Neurosurgical Institute, 4-ya Tverskaya-Yamskaya Str., 16, Moscow, Russia, 125047.

The most common clinical manifestations of space-occupying lesions of the midbrain and pineal region are oculomotor and pupil disorders and ophthalmoscopic signs of intracranial hypertension.

Purpose: To identify patterns of neuro-ophthalmic symptoms before and after surgical treatment in patients with space-occupying lesions of the midbrain and pineal region.

Material And Methods: We analyzed neurological symptoms in 231 patients with space-occupying lesions of the midbrain and pineal region before and after surgical treatment. Read More

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http://dx.doi.org/10.17116/neiro201882342DOI Listing
January 2018
9 Reads

Suprasellar Germinomas: 2 Case Reports and Literature Review.

World Neurosurg 2018 Sep 15;117:165-171. Epub 2018 Jun 15.

Pathology Institute of Passo Fundo, Passo Fundo, Brazil.

Background: Germinomas are rare malignant central nervous system tumors, a type of germ cell tumor, according to the 2016 World Health Organization Classification of Brain Tumors. Most of these tumors develop along the midline, most often from the pineal gland, followed by tumors arising in the suprasellar cisterns. Suprasellar germinomas commonly manifest with diabetes insipidus, visual impairment, and hypothalamic-pituitary failure. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.06.041DOI Listing
September 2018
15 Reads

Sleep disorders in children with incidental pineal cyst on MRI: a pilot study.

Sleep Med 2018 Aug 16;48:127-130. Epub 2018 May 16.

Sleep Research Centre, Oasi Research Institute IRCCS, Troina, Italy.

Introduction: For several years, pineal cysts have been considered an incidental finding on brain MRI's even though research and case reports have shown a possible association of pineal cysts with headaches and sleep disturbances. This pilot study aims to evaluate sleep disorders in school-age children with an incidental pineal cyst in an otherwise normal brain MRI.

Method: Children aged 6-12 years, who were referred for evaluation of headaches, tics, or syncope, and had an incidental pineal cyst on an otherwise normal brain MRI were included and compared to a control group of children with the same referral reasons but with a normal MRI and to a cohort of normal controls. Read More

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http://dx.doi.org/10.1016/j.sleep.2018.05.003DOI Listing
August 2018
4 Reads

Papillary Tumor of the Pineal Region in Children: Presentation of a Case and Comprehensive Literature Review.

World Neurosurg 2018 Sep 12;117:144-152. Epub 2018 Jun 12.

Department of Neurosurgery, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.

Background: Papillary tumor of the pineal region (PTPR) is a rare grade II-III pineal lesion with peculiar histological and immunohistochemical features. These tumors mostly occur in adults, only rarely in children, with 19 cases reported up to now.

Case Description: We present a 3-year-old boy who underwent reoperation for a recurrent PTPR (grade II). Read More

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http://dx.doi.org/10.1016/j.wneu.2018.06.020DOI Listing
September 2018
2 Reads
2.420 Impact Factor

The role of indocyanine green videoangiography with FLOW 800 analysis for the surgical management of central nervous system tumors: an update.

Neurosurg Focus 2018 Jun;44(6):E6

OBJECTIVE Indocyanine green videoangiography (ICG-VA) is an intraoperative technique used to highlight vessels in neurovascular surgery. Its application in the study of the vascular pathophysiology in CNS tumors and its role in their surgical management are still rather limited. A recent innovation of ICG-VA (i. Read More

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http://dx.doi.org/10.3171/2018.3.FOCUS1862DOI Listing
June 2018
9 Reads

Outcome of single-trajectory rigid endoscopic third ventriculostomy and biopsy in the management algorithm of pineal region tumors: a case series and review of the literature.

Childs Nerv Syst 2018 Jul 28;34(7):1335-1344. Epub 2018 May 28.

Neurosurgery Department, Alexandria University, Khartoum sq. Al-Azareeta, Faculty of Medicine, Surgery Building 6th Floor Neurosurgery Department, Alexandria, Egypt.

Background: Tumors within the pineal region represent 1.5 to 8.5% of the pediatric brain tumors and 1. Read More

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http://dx.doi.org/10.1007/s00381-018-3840-8DOI Listing
July 2018
9 Reads

Long-Term Follow-Up After Radiosurgery of Papillary Tumor of Pineal Region: 2 Case Reports and Review of Literature.

World Neurosurg 2018 Aug 19;116:190-193. Epub 2018 May 19.

Department of Neurosurgery, Hospital Universitario Puerta de Hierro-Majadahonda, Madrid, Spain.

Background: Tumors of the pineal region are rare in adulthood, accounting for approximately 1% of intracranial neoplasms in this age range. Because of their rarity, it has proven to be difficult to establish the optimal therapy. Furthermore, microsurgical total resection in this eloquent location is associated with not low rates of morbidity. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18788750183103
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http://dx.doi.org/10.1016/j.wneu.2018.05.080DOI Listing
August 2018
4 Reads

Safety of commercial airflight in patients with brain tumors: a case series.

J Neurooncol 2018 Sep 17;139(3):617-623. Epub 2018 May 17.

Pacific Neuroscience Institute, Brain Tumor Center & Pituitary Disorders Program, John Wayne Cancer Institute at Providence Saint John's Health Center, 2200 Santa Monica Blvd., Santa Monica, CA, 90404, USA.

Introduction: Patients with intracranial masses are often advised to avoid airflight due to concerns of worsening neurological symptoms or deterioration. However, many patients often travel cross-country or internationally to tertiary care centers for definitive care. This study assesses the safety of commercial airflight for brain and skull base tumor patients without severe or progressive neurological deficits. Read More

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http://dx.doi.org/10.1007/s11060-018-2905-6DOI Listing
September 2018
3 Reads

Melatonin attenuates osteosarcoma cell invasion by suppression of C-C motif chemokine ligand 24 through inhibition of the c-Jun N-terminal kinase pathway.

J Pineal Res 2018 Oct 28;65(3):e12507. Epub 2018 May 28.

Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan.

Osteosarcoma, with its high metastatic potential, is the most prevalent malignant bone tumor in children and adolescents. Melatonin possesses multiple tumor-suppressing properties for a myriad of tumors, but little is known about the effects of melatonin on osteosarcoma metastasis. In this study, we demonstrated that melatonin elicited very low cytotoxicity and significantly inhibited cellular motility, migration, and invasion in human osteosarcoma U2OS and HOS cells. Read More

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http://dx.doi.org/10.1111/jpi.12507DOI Listing
October 2018
1 Read

Cognitive Profile of Children With Intracranial Germ Cell Tumor According to Tumor Location.

J Pediatr Hematol Oncol 2018 Oct;40(7):e424-e428

Department of Pediatric and Adolescent Oncology, Gustave Roussy.

Purpose: The purpose of this study was to evaluate the long-term cognitive sequelae and to describe the neuropsychological profile of patients with intracranial germ cell tumors according to tumor location (pineal or suprasellar site).

Patients And Methods: Forty-five children treated at Gustave Roussy between 1991 and 2010 were assessed with neuropsychological tests to measure IQ, memory, visuospatial, motor, and executive skills at a mean delay of 4.2 years after diagnosis. Read More

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http://Insights.ovid.com/crossref?an=00043426-201810000-0002
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http://dx.doi.org/10.1097/MPH.0000000000001200DOI Listing
October 2018
1 Read

Retrospective Analysis of the Clinical Characteristics, Therapeutic Aspects, and Prognostic Factors of 18 Cases of Childhood Pineoblastoma.

World Neurosurg 2018 Aug 27;116:e162-e168. Epub 2018 Apr 27.

Department of Neurosurgery, Beijing TianTan Hospital, Capital Medical University, China National Clinical Research Center for Neurological Diseases (NCRC-ND), Center for Brain Tumor, Beijing Institute for Brain Disorders, Beijing Key Laboratory for Brain Tumor, Beijing, China. Electronic address:

Background: Pineoblastoma is a rare malignant tumor of the pineal gland, which is more common in children.

Methods: We retrospectively reviewed 18 cases of pineoblastoma in children (10 girls), including general, clinical, and therapeutic information, and factors affecting prognosis.

Results: The median age of the children was 51. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18788750183085
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http://dx.doi.org/10.1016/j.wneu.2018.04.135DOI Listing
August 2018
15 Reads