2,968 results match your criteria Pineal Tumors


Comparison between Craniospinal Irradiation and Limited-Field Radiation in Patients with Non-metastatic Bifocal Germinoma.

Cancer Res Treat 2020 Jul 9. Epub 2020 Jul 9.

Department of Radiation Oncology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.

Purpose: Whether craniospinal irradiation (CSI) could be replaced by limited-field radiation in non-metastatic bifocal germinoma remains controversial. We addressed the issue based on the data from our series and the literature.

Methods: Data from 49 patients diagnosed with non-metastatic bifocal germinoma at our hospital during the last 10 years were collected. Read More

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http://dx.doi.org/10.4143/crt.2020.437DOI Listing

Switching Diseased Cells from Cytosolic Aerobic Glycolysis to Mitochondrial Oxidative Phosphorylation: A Metabolic Rhythm Regulated by Melatonin?

J Pineal Res 2020 Jul 3:e12677. Epub 2020 Jul 3.

Department of Cell Systems and Anatomy, UT Health Science Center at San Antonio, San Antonio, Texas, USA.

This commentary reviews the concept of the circadian melatonin rhythm playing an essential role in reducing the development of diseases such as solid tumors which adopt cytosolic aerobic glycolysis (Warburg effect) to support their enhanced metabolism. Experimental data shows that solid mammary tumors depend on aerobic glycolysis during the day but likely revert to mitochondrial oxidative phosphorylation at night for ATP production. This conversion of diseased cells during the day to a healthier phenotype at night occurs under control of the circulating melatonin rhythm. Read More

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http://dx.doi.org/10.1111/jpi.12677DOI Listing

Pulmonary Adenocarcinoma Presenting as a Pineal Gland Mass With Obstructive Hydrocephalus.

Ochsner J 2020 ;20(2):232-235

Department of Internal Medicine, University of South Dakota Sanford School of Medicine, Sioux Falls, SD.

Adenocarcinoma is the most prevalent type of non-small cell carcinoma of the lungs. Patients with lung adenocarcinoma often present with cough, dyspnea, pain, and weight loss. They can also present with signs and symptoms of brain metastasis because the lungs are one of the most common origins of metastatic brain cancer. Read More

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http://dx.doi.org/10.31486/toj.18.0159DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310168PMC
January 2020

Pleomorphic Xanthoastrocytoma of the Pineal Region in a Pediatric Patient With Neurofibromatosis Type 1.

Ochsner J 2020 ;20(2):226-231

Department of Neurosurgery, Ochsner Clinic Foundation, New Orleans, LA.

Pleomorphic xanthoastrocytoma (PXA) is a rare and often focal glioma that most commonly affects children and young adults. Lesions are preferentially supratentorial and superficial, although infratentorial masses have been described, along with occasional involvement of the leptomeninges. The World Health Organization (WHO) categorizes these tumors as grade II, with surgical resection carrying a favorable prognosis. Read More

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http://dx.doi.org/10.31486/toj.18.0156DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310189PMC
January 2020

Transcallosal-lateral ventricle-choroid fissure approach for excising large pineal region tumors extending into the third ventricle: experience in 15 pediatric cases.

Childs Nerv Syst 2020 Jun 25. Epub 2020 Jun 25.

Department of Neurosurgery, The Second Affiliated Hospital of Guangxi Medical University, Nanning, 530007, Guangxi, People's Republic of China.

Pineal region is deep located and tightly connected with surrounding important nerves, blood vessels, and other critical structure. Tumors in the regions are more commonly observed in children with complex pathology, difficult surgery, and poor prognosis. However, excision surgery on large tumor in the pineal region and extending into the third ventricle is characterized by high difficulty and uneasy treatment. Read More

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http://dx.doi.org/10.1007/s00381-020-04742-zDOI Listing

INCIDENTAL FINDINGS ON BRAIN MAGNETIC RESONANCE IMAGING (MRI) IN PEDIATRIC ENDOCRINE PATIENTS.

Endocr Pract 2020 Jun 23. Epub 2020 Jun 23.

From: Pediatric Endocrinology and Diabetes Unit.

To explore incidental findings on brain magnetic resonance imaging (MRI) studies of pediatric patients referred due to endocrine disorders. A retrospective, observational study conducted in a tertiary referral center. The neuroimaging database of 17,445 brain MRI studies of 11,011 pediatric patients were searched for cases with endocrine referrals and without medical history of malignancy, genetic syndromes and/or neurological comorbidities. Read More

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http://dx.doi.org/10.4158/EP-2020-0208DOI Listing

Continuous progression of hemorrhage of sphenoid ridge meningioma causing cerebral hernia: A case report and literature review.

Oncol Lett 2020 Jul 6;20(1):785-793. Epub 2020 May 6.

Department of Neurosurgery, Sanbo Brain Hospital, Capital Medical University, Beijing 100093, P.R. China.

The aim of the present study was to explore the clinical characteristics of repeated hemorrhages of meningioma and analyze the causes of hemorrhage. Meningiomas are mostly benign tumors that rarely manifest hemorrhagic strokes. In the present study, a case of sphenoid ridge meningioma with repeated hemorrhages is reported. Read More

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http://dx.doi.org/10.3892/ol.2020.11590DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7285884PMC

Simultaneous single-trajectory endoscopic biopsy and third ventriculostomy in pediatric pineal region tumors.

Acta Neurol Belg 2020 Jun 6. Epub 2020 Jun 6.

Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China.

Pineal region tumors have different pathological tumors and their optimal management remains controversial. Advancements in neuroendoscopy have led to the ability to simultaneously treat the hydrocephalus and obtain a tissue diagnosis. A retrospective review of 34 patients with pineal region tumors in Beijing Tiantan hospital from the year 2016 to 2018 was undertaken. Read More

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http://dx.doi.org/10.1007/s13760-020-01387-2DOI Listing

Management of pineal region tumors in a pediatric case series.

Neurosurg Rev 2020 Jun 6. Epub 2020 Jun 6.

Pediatric Neurosurgery, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Augustenburger Platz 1, 13353, Berlin, Germany.

Pineal region tumors commonly present with non-communicating hydrocephalus. These heterogeneous histological entities require different therapeutic regimens. We evaluated our surgical experience concerning procurance of a histological diagnosis, management of hydrocephalus, and choice of antitumoral treatment. Read More

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http://dx.doi.org/10.1007/s10143-020-01323-1DOI Listing

Induction chemotherapy reduces radiotherapy dose and volume in the treatment of intracranial germinoma: Results of the SMC-G13 trial.

Int J Radiat Oncol Biol Phys 2020 Jun 2. Epub 2020 Jun 2.

Department of Neurosurgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.

Background: We performed a prospective single arm trial (NCT********) to explore the feasibility of reducing radiotherapy (RT) dose when induction chemotherapy is combined in the treatment of intracranial germinoma with β-HCG levels < 200 mIU/ml.

Methods: All patients aged 3 to 35 years from November 2012 to June 2018 were eligible for this study. Four cycles of induction chemotherapy were given prior to RT. Read More

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http://dx.doi.org/10.1016/j.ijrobp.2020.05.051DOI Listing

Pineal gland protects against chemically induced oral carcinogenesis and inhibits tumor progression in rats.

Oncotarget 2020 May 19;11(20):1816-1831. Epub 2020 May 19.

Psychoneuroimmunology Laboratory, Psychosomatic Research Center, Oral Oncology Center, São Paulo State University (Unesp), School of Dentistry, SP 15050-015, Araçatuba, São Paulo, Brazil.

Clinical investigations suggest that melatonin suppression and circadian dysfunction may be related to cancer development in shift workers. Studies also show that melatonin suppression after pinealectomy increases cancer incidence in preclinical models. However, no study evaluated the influence of pinealectomy on oral cancer development. Read More

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http://dx.doi.org/10.18632/oncotarget.27551DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7244010PMC

Two-Session Radiosurgery for Large Primary Tumors Affecting the Brain.

Cureus 2020 Apr 27;12(4):e7850. Epub 2020 Apr 27.

Radiosurgery, International Cancer Center, Diagnostic Hospital, San Salvador, SLV.

Introduction Surgery is an option for patients with large, symptomatic primary tumors affecting the brain. However, surgery might not be suitable for all tumors, especially those located in sensitive areas such as the pineal region and the hypothalamus. Single-session stereotactic radiosurgery (SRS) might not provide an adequate dose for long-term local control due to the initial tumor volume and the involvement of radiation sensitive organs at risk (OARs). Read More

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http://dx.doi.org/10.7759/cureus.7850DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7255071PMC

Reinvestigation of the origins of pineal meningiomas based on its related veins and arachnoid membranes.

BMC Neurol 2020 May 20;20(1):200. Epub 2020 May 20.

Department of Neurosurgery, Nanfang Hospital, Southern Medical University, 1838 Guangzhou Dadao Bei Street, Guangzhou, 510515, P. R. China.

Background: A series of patients harboring pineal region meningiomas were respectively analyzed to explore the origin of these tumors and the true meaning of the term "velum interpositum (VI) meningiomas".

Methods: 21 patients with pineal meningiomas underwent operation in Nanfang Hospital of Southern Medical University from January 2005 to December 2016 were retrospectively included to analyze the clinical features, imaging findings and surgical video data of these patients. According to the method of literature, the data of this group were also divided into falcotentorial (FT) meningiomas and VI meningiomas, and the differences between the two types of tumors were compared. Read More

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http://dx.doi.org/10.1186/s12883-020-01783-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238570PMC

Refinement of the clinical and mutational spectrum of UBE2A deficiency syndrome.

Clin Genet 2020 May 15. Epub 2020 May 15.

Genetics and Rare Diseases Research Division, Ospedale Pediatrico Bambino Gesù, IRCSS, Rome, Italy.

UBE2A deficiency, that is, intellectual disability (ID) Nascimento type (MIM 300860), is an X-linked syndrome characterized by developmental delay, moderate to severe ID, seizures, dysmorphisms, skin anomalies, and urogenital malformations. Forty affected subjects have been reported thus far, with 31 cases having intragenic UBE2A variants. Here, we report on additional eight affected subjects from seven unrelated families who were found to be hemizygous for previously unreported UBE2A missense variants (p. Read More

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http://dx.doi.org/10.1111/cge.13775DOI Listing

Pituitary germinomas: a multi-institutional study analyzing patient demographics and management patterns.

Pituitary 2020 Aug;23(4):381-388

Department of Neurosurgery, University of Illinois at Chicago College of Medicine, 912 S. Wood Street, 4N NPI, Chicago, IL, 60612, USA.

Purpose: Intracranial germinomas are exceedingly rare tumors found in the pineal and suprasellar regions. The extremely low incidence of pituitary germinoma has resulted in a significant gap in knowledge regarding its demographics, management, and treatment outcomes. We present the largest multicenter analysis of pituitary germinomas to date, focused on analyzing demographic and management patterns. Read More

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http://dx.doi.org/10.1007/s11102-020-01042-2DOI Listing

Placental alkaline phosphatase in cerebrospinal fluid as a biomarker for optimizing surgical treatment strategies for pineal region germ cell tumors.

Brain Tumor Pathol 2020 Apr 5;37(2):60-68. Epub 2020 May 5.

Department of Neurosurgery, Tokyo Women's Medical University, 8-1 Kawada-cho Shinjuku-ku, Tokyo, 162-8666, Japan.

Pineal region germ cell tumors are a heterogenous group of tumors; of these, pure germinoma shows high sensitivity to adjuvant therapy, and the timing and sequence of surgical intervention and adjuvant/neoadjuvant therapy are important for devising a treatment strategy for intracranial germ cell tumors (IGCT). Biopsy is diagnostically useful, but is often insufficient because only a limited amount of specimen can be obtained. In the present study, we aimed to determine the value of cerebrospinal fluid placental alkaline phosphatase (PLAP) levels, reflecting the presence of germinoma, as a reliable indicator to determine treatment strategies for pineal germ cell tumors. Read More

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http://dx.doi.org/10.1007/s10014-020-00364-0DOI Listing

Surgical treatment of a rare rosette-forming glioneuronal tumor in the pineal region.

Surg Neurol Int 2020 18;11:68. Epub 2020 Apr 18.

Department of Neurosurgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

Background: Rosette-forming glioneuronal tumors (RGNTs) in the pineal region are rare. RGNTs have been described in the fourth ventricle, but rarely reported in other brain regions. Here, we report the radiological findings, surgical treatment, and short-term outcome of an RGNT found in the pineal region. Read More

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http://dx.doi.org/10.25259/SNI_294_2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7193215PMC

A biphasic tumor in posterior cranial fossa and the pineal region in young adult.

Surg Neurol Int 2020 11;11:64. Epub 2020 Apr 11.

Departments of Neurosurgery, University Hospital Dubrava, Zagreb, Croatia.

Background: Biphasic tumors of the central nervous system are rarely described and mainly consisted out of the glial and mesenchymal component. The tumor originated out of both astrocytes and pinealocytes, best to our knowledge, has not been described. We present a case of a brain tumor consisted out of pilocytic astrocytoma (PA) and pineocytoma as components situated in the pineal region and posterior cranial fossa in young adult. Read More

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http://dx.doi.org/10.25259/SNI_288_2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7193197PMC

Precision of preoperative diagnosis in patients with brain tumor - A prospective study based on "top three list" of differential diagnosis for 1061 patients.

Surg Neurol Int 2020 28;11:55. Epub 2020 Mar 28.

Department of Neurosurgery, Kagoshima University, Sakuragaoka, Kagoshima, Japan.

Background: Accurate diagnosis of brain tumor is crucial for adequate surgical strategy. Our institution follows a comprehensive preoperative evaluation based on clinical and imaging information.

Methods: To assess the precision of preoperative diagnosis, we compared the "top three list" of differential diagnosis (the first, second, and third diagnoses according to the WHO 2007 classification including grading) of 1061 brain tumors, prospectively and consecutively registered in preoperative case conferences from 2010 to the end of 2017, with postoperative pathology reports. Read More

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http://dx.doi.org/10.25259/SNI_5_2020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7193216PMC

Novel Diagnostic Methods and Posttreatment Clinical Phenotypes Among Intracranial Germ Cell Tumors.

Neurosurgery 2020 Apr 29. Epub 2020 Apr 29.

Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota.

Background: Central nervous system (CNS) germ cell tumors (GCT) are rare and complex pediatric neoplasms, the optimal management of which remains an area of active investigation.

Objective: To present an updated cohort study, with particular attention to novel diagnostic methods and posttreatment clinical phenotypes.

Methods: A single-institution cohort study of 80 primary, neurosurgically managed, CNS GCTs was conducted at Mayo Clinic, 1988-2017. Read More

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http://dx.doi.org/10.1093/neuros/nyaa108DOI Listing

[Purely endoscopic supracerebellar infratentorial approach for epidermoid cyst in third ventricle].

Surg Neurol Int 2019 25;10(Suppl 1):S21-S25. Epub 2019 Jun 25.

Hospital Nacional Profesor Alejandro Posadas, Department of Neurosurgery, Av. Pres. Arturo Illia, El Palomar, Buenos Aires, CP 1684, Argentina.

Background: The epidermoid cyst as a pineal region tumor is an infrequent pathology and with few descriptions in literature. Its prevalence in the third ventricle is 0,0042% of all intracranial tumors. To achieve a complete exéresis we used an endoscopic supracerebellar-infratentorial approach, surgical technique for pineal region approach. Read More

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http://dx.doi.org/10.25259/SNI-93-2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7159061PMC

Intracranial growing teratoma syndrome (iGTS): an international case series and review of the literature.

J Neurooncol 2020 May 15;147(3):721-730. Epub 2020 Apr 15.

Section of Pediatric Hematology Oncology and Bone Marrow Transplantation, Alberta Children's Hospital, 28 Oki Drive NW, Calgary, AB, T3B 6A8, Canada.

Purpose: Intracranial growing teratoma syndrome (iGTS) is a rare phenomenon of paradoxical growth of a germ cell tumor (GCT) during treatment despite normalization of tumor markers. We sought to evaluate the frequency, clinical characteristics and outcome of iGTS in Western countries.

Methods: Pediatric patients from 22 North American and Australian institutions diagnosed with iGTS between 2000 and 2017 were retrospectively evaluated. Read More

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http://dx.doi.org/10.1007/s11060-020-03486-9DOI Listing
May 2020
3.070 Impact Factor

Parieto-Occipital Interhemispheric Transfalcine, Trans-Bitentorial Approach for Radical Resection of Falcotentorial Meningiomas.

J Neurol Surg A Cent Eur Neurosurg 2020 Jul 15;81(4):355-361. Epub 2020 Apr 15.

Department of Pathology, National Hospital Organization, Yokohama Medical Center, Yokohama, Japan.

Objective:  Falcotentorial meningioma occurs close to the falcotentorial edges and the confluence of the vein of Galen. The posterosuperior approach conventionally used to reach this site does not allow direct visualization of the tumor matrix, making detachment difficult. Meningiomas at this location are therefore among those that are not well amenable to radical resection. Read More

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http://dx.doi.org/10.1055/s-0039-1685181DOI Listing

Serum melatonin is inversely associated with matrix metalloproteinase-9 in oral squamous cell carcinoma.

Oncol Lett 2020 Apr 13;19(4):3011-3020. Epub 2020 Feb 13.

ENT Department, Maria Sklodowska Curie Children's Emergency Hospital, Bucharest 077120, Romania.

Matrix-metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) expression levels have been demonstrated to have prognostic value in oral squamous cell carcinoma (OSCC). The present study hypothesized that melatonin, a small lipophilic molecule primarily secreted by the pineal gland, may be able to regulate MMP activity in OSCC progression. This study aimed to investigate the associations between melatonin, MMPs, TIMPs and the histopathological characteristics of patients with OSCC. Read More

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http://dx.doi.org/10.3892/ol.2020.11392DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7068641PMC

Endoscopic-assisted surgery versus microsurgery for pineal region tumors: a single-center retrospective study.

Neurosurg Rev 2020 Mar 20. Epub 2020 Mar 20.

Department of Neurosurgery, Zhongnan Hospital of Wuhan University, Wuhan University, 169 Donghu Rd, Wuhan, 430071, China.

Pineal region tumors are extremely deep-seated and surgically challenging. The exposure and visualization obtained by microscopic surgery are relatively limiting. The application of high-definition endoscopes has recently provided neurosurgeons with a much more magnified and clearer view of the anatomy in the pineal region. Read More

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http://dx.doi.org/10.1007/s10143-020-01283-6DOI Listing

Endocrine manifestations of central nervous system germ cell tumors in children.

Endocrinol Diabetes Nutr 2020 Mar 17. Epub 2020 Mar 17.

Servicio de Pediatría, Hospital Universitario Virgen del Rocío, Sevilla, España.

Introduction: Central nervous system germ cell tumors need to be adequately diagnosed because their treatment is usually effective and they do not always require surgery. The study objectives are to describe the endocrine manifestations of these tumors and to compare the time of their onset to that of the occurrence of neurological and visual changes.

Patients And Methods: The medical histories of patients under 14 years of age seen at a pediatric endocrinology unit between 2000 and 2018 were reviewed. Read More

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http://dx.doi.org/10.1016/j.endinu.2019.11.012DOI Listing

Role of susceptibility-weighted imaging and intratumoral susceptibility signals in grading and differentiating pediatric brain tumors at 1.5 T: a preliminary study.

Neuroradiology 2020 Jun 6;62(6):705-713. Epub 2020 Mar 6.

UOC Radiodiagnostica e Neuroradiologia, Dipartimento di Diagnostica per Immagini, Radioterapia, Oncologia ed Ematologia, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.

Purpose: Susceptibility-weighted imaging (SWI) is useful for glioma grading and discriminating between brain tumor categories in adults, but its diagnostic value for pediatric brain tumors is unclear. Here we evaluated the usefulness of SWI for pediatric tumor grading and differentiation by assessing intratumoral susceptibility signal intensity (ITSS).

Methods: We retrospectively enrolled 96 children with histopathologically diagnosed brain tumors, who underwent routine brain MRI exam with SWI (1. Read More

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http://dx.doi.org/10.1007/s00234-020-02386-zDOI Listing

One- vs Two-Burr-Hole Technique for Combined Endoscopic Third Ventriculostomy and Pineal Region Biopsy: Volumetric Analysis of Brain at Risk.

Oper Neurosurg (Hagerstown) 2020 Mar 4. Epub 2020 Mar 4.

Department of Neurosurgery, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, Arizona.

Background: Pineal region tumors are associated with the ventricular system. Endoscopic third ventriculostomy (ETV) is often performed at the same time as tumor biopsy.

Objective: To investigate the volume of brain possibly undergoing injury and forniceal stretching during ETV and tumor biopsy. Read More

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http://dx.doi.org/10.1093/ons/opaa010DOI Listing

Role of endoscopic surgical biopsy in diagnoses of intraventricular/periventricular tumors: review of literature including a monocentric case series.

Acta Neurol Belg 2020 Jun 27;120(3):517-530. Epub 2020 Feb 27.

Human Neurosciences Department, Neurosurgery Division, "Sapienza" University, AOU Policlinico Umberto I, Rome, Italy.

The intra- and periventricular location tumor (IPVT) of a brain remains a hard challenge for the neurosurgeon because of the deep location and eloquent anatomic associations. Due to this high risk of iatrogenic injury, many surgeons elect to perform biopsies of such lesions to establish a diagnosis. On the one hand, stereotaxic needle biopsy (SNB) is a minimally invasive procedure but with a significant risk of complications and a high risk of lack of tissue for molecular analyses for this region [Fukushima in Neurosurgery 2:110-113 (1978)]; on the other hand, the use of endoscopic intraventricular biopsy (EIB) allows for diagnosis with minimal surgical intervention [Iwamoto et al. Read More

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http://dx.doi.org/10.1007/s13760-020-01299-1DOI Listing

Primary Paravertebral Germ Cell Tumor Demonstrated by FDG PET/CT.

Clin Nucl Med 2020 Apr;45(4):322-323

From the Department of Nuclear Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

Extragonadal germ cell tumors are rare. Most of these tumors occur in the anterior mediastinum, retroperitoneum, pineal gland, or suprasellar region. Here, we present a case of a 29-year-old man with a paravertebral mass to the right of the T8 and T9 vertebral bodies on MRI and FDG PET/CT. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002953DOI Listing

Epidemiology, natural history, and optimal management of neurohypophyseal germ cell tumors.

J Neurosurg 2020 Feb 7:1-9. Epub 2020 Feb 7.

Departments of1Neurologic Surgery and.

Objective: Intracranial germ cell tumors (iGCTs) often arise at the neurohypophysis, their second most common origination, following the pineal region. Neurohypophyseal iGCTs present with stereotypical symptoms, including pituitary dysfunction and visual field deficit, due to their suprasellar location. The goal of this study was to present a large, longitudinal single-institution experience with neurohypophyseal iGCTs to better understand their natural history and identify opportunities for further improvement in treatment outcomes. Read More

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http://dx.doi.org/10.3171/2019.10.JNS191136DOI Listing
February 2020

Papillary tumor in pineal region: Immunohistochemistry meeting the diagnostic challenge.

Indian J Pathol Microbiol 2020 Jan-Mar;63(1):100-102

Department of Pathology, PGIMER, Dr RML Hospital, New Delhi, India.

Papillary tumor of pineal region (PTPR) is extremely rare and poses diagnostic challenge with other central nervous system tumors having papillary architecture. Immunohistochemistry is crucial for a definitive diagnosis of PTPR. Read More

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http://dx.doi.org/10.4103/IJPM.IJPM_102_19DOI Listing
February 2020

Comparison on epidemiology, tumor location, histology, and prognosis of intracranial germ cell tumors between Mayo Clinic and Japanese consortium cohorts.

J Neurosurg 2020 Jan 31:1-11. Epub 2020 Jan 31.

Departments of1Neurologic Surgery and.

Objective: Central nervous system (CNS) germ cell tumors (GCTs) are rare malignant neoplasms that arise predominantly in adolescents and young adults. CNS GCTs demonstrate characteristic trends in national associations, with implications for both tumor incidence and genetics. Although the incidence of CNS GCTs is markedly higher in East Asia than Western countries, direct comparative analyses between these CNS GCT populations are limited. Read More

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http://dx.doi.org/10.3171/2019.11.JNS191576DOI Listing
January 2020

Adherence of US Insurance Payer Policies to the American Society of Radiation Oncology Stereotactic Radiosurgery Model Policy.

Pract Radiat Oncol 2020 Jul - Aug;10(4):e250-e254. Epub 2020 Jan 28.

Department of Radiation Oncology, Washington University School of Medicine, St Louis, Missouri. Electronic address:

Purpose: The medical necessity of stereotactic radiosurgery (SRS) is nonuniform across insurance policies. The American Society for Radiation Oncology (ASTRO) created a model policy based on the consensus of the radiation oncology community to communicate medically necessary indications for SRS. We compared the current insurance policies for SRS with those of the ASTRO model policy. Read More

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http://dx.doi.org/10.1016/j.prro.2020.01.006DOI Listing
January 2020

Midline and Paramedian Supracerebellar Infratentorial Approach to The Pineal Region: A Comparative Clinical Study in 112 Patients.

World Neurosurg 2020 May 28;137:e194-e207. Epub 2020 Jan 28.

Department of Neurosurgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; Juha Hernesniemi International Center for Neurosurgery, Henan Provincial People's Hospital, Zhengzhou, China.

Objective: The midline supracerebellar infratentorial (SCIT) approach and its paramedian development are commonly used for dealing with pineal lesions. Comparative clinical studies are lacking, however. We aim to establish the better performance of the paramedian SCIT approach in terms of clinical safety in surgically treated pineal cysts and pineal region tumors. Read More

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http://dx.doi.org/10.1016/j.wneu.2020.01.137DOI Listing
May 2020
2.417 Impact Factor

A Rare Case of Intracranial Nongerminomatous Germ Cell Tumor in a 21-Year-Old Romanian Male.

Case Rep Oncol Med 2020 3;2020:3787250. Epub 2020 Jan 3.

Department of Neurological Critical Care Medicine, AtlantiCare Regional Medical Center, 1925 Pacific Avenue, Atlantic City, NJ, USA.

Extragonadal germ cell tumors are a rare entity that is more prevalent in infants and young children, with preference to midline structures. The category of intracranial germ cell tumors is divided into pure germ cell tumors (GCTs) versus nongerminomatous germ cell tumors (NGGCTs). They are usually present in the second decade of life with a male preponderance. Read More

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http://dx.doi.org/10.1155/2020/3787250DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6964716PMC
January 2020

Teratoma involving adrenal gland - A case report and review of literature.

Indian J Radiol Imaging 2019 Oct-Dec;29(4):472-476. Epub 2019 Dec 31.

Department of Radiodiagnosis, Shri M.P. Shah Government Medical College and Shri Gurugobind Singh Government Hospital, P.N. Marg, Jamnagar, Gujarat, India.

Teratomas are germ cell tumors which are mainly gonadal in origin. Other common extra-gonadal sites are mediastinal, sacro-coccygeal and pineal regions. Adrenal teratomas are extremely rare and primary adrenal teratomas are even rarer. Read More

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http://dx.doi.org/10.4103/ijri.IJRI_452_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6958897PMC
December 2019

Magnetic Resonance Imaging Screening for Trilateral Retinoblastoma: The Memorial Sloan Kettering Cancer Center Experience 2006-2016.

Ophthalmol Retina 2020 03 31;4(3):327-335. Epub 2019 Oct 31.

Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York; Department of Ophthalmology, Weill Cornell Medical School, New York, New York.

Purpose: Magnetic resonance imaging (MRI) has been used for baseline brain imaging and afterward as a screening tool for trilateral retinoblastoma (TRB), but there is no consensus on timing or frequency of screening worldwide. In this study, a cohort of hereditary retinoblastoma patients at increased risk for TRB was identified and the usefulness of aggressive neuroimaging was examined.

Design: Retrospective review of the medical records and MRI reports of patients with retinoblastoma treated at Memorial Sloan Kettering Cancer Center between January 1, 2006, and December 31, 2016. Read More

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http://dx.doi.org/10.1016/j.oret.2019.10.010DOI Listing

Primary Pineal Rhabdomyosarcoma: A Rare Case.

Asian J Neurosurg 2019 Oct-Dec;14(4):1291-1294. Epub 2019 Nov 25.

Department of Pathology, Seth G.S.M.C, Mumbai, Maharashtra, India.

Primary pineal rhabdomyosarcoma (RMS) is extremely rare, and only three cases have been reported so far. Here, we report a case of 12-year-old male who presented with complaints of diplopia and diminution of vision since 15 days. He also had left-sided facial paresis. Read More

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http://dx.doi.org/10.4103/ajns.AJNS_53_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6896613PMC
November 2019

Melatonin suppresses epithelial‑to‑mesenchymal transition in the MG‑63 cell line.

Mol Med Rep 2020 Mar 23;21(3):1356-1364. Epub 2019 Dec 23.

Department of Orthopaedics, The First Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technology, Baotou, Inner Mongolia 014010, P.R. China.

Epithelial‑to‑mesenchymal transition (EMT) is a major process involved in tumor progression and metastasis. Melatonin is secreted by the pineal gland and has been documented as a potential therapeutic agent for multiple tumors. However, the effects of melatonin on EMT during osteosarcoma (OA) development remain undefined. Read More

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http://dx.doi.org/10.3892/mmr.2019.10902DOI Listing

Surgical approaches in pediatric neuro-oncology.

Cancer Metastasis Rev 2019 12;38(4):723-747

Department of Neurosurgery, Great Ormond Street Hospital for Children NHS Foundation Trust, Great Ormond Street, London, England, WC1N 3JH, UK.

Tumors of the central nervous system comprise nearly a quarter of all childhood cancers and are the most frequent solid tumor in the pediatric population. The most common location is in the posterior fossa, but tumors can occur anywhere intracranially. The spectrum of lesions encountered varies, from being completely benign and requiring surveillance alone to being highly malignant and requiring aggressive treatment in the form of surgery and adjuvant therapy. Read More

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http://dx.doi.org/10.1007/s10555-019-09832-2DOI Listing
December 2019

[Primary pineal melanocytoma: clinical case and literature review].

Zh Vopr Neirokhir Im N N Burdenko 2019 ;83(5):44-50

Burdenko Neurosurgical Center, Moscow, Russia.

Primary pineal melanocytomas are extremely rare pathologies and predominantly are clinically manifested by nonspecific symptoms of a pineal affect, which could be characteristic for tumors of different histological nature located in the same region. Also these tumors differ from other melanocytic tumors by their slow growth and relatively favorable clinical prognosis. Read More

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http://dx.doi.org/10.17116/neiro20198305144DOI Listing
January 2020

Pineoblastoma segregates into molecular sub-groups with distinct clinico-pathologic features: a Rare Brain Tumor Consortium registry study.

Acta Neuropathol 2020 02 9;139(2):223-241. Epub 2019 Dec 9.

Service d'Anatomie et Cytologie Pathologiques, CHU de Lyon, Lyon, France.

Pineoblastomas (PBs) are rare, aggressive pediatric brain tumors of the pineal gland with modest overall survival despite intensive therapy. We sought to define the clinical and molecular spectra of PB to inform new treatment approaches for this orphan cancer. Tumor, blood, and clinical data from 91 patients with PB or supratentorial primitive neuroectodermal tumor (sPNETs/CNS-PNETs), and 2 pineal parenchymal tumors of intermediate differentiation (PPTIDs) were collected from 29 centres in the Rare Brain Tumor Consortium. Read More

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http://dx.doi.org/10.1007/s00401-019-02111-yDOI Listing
February 2020

Risk-adapted therapy and biological heterogeneity in pineoblastoma: integrated clinico-pathological analysis from the prospective, multi-center SJMB03 and SJYC07 trials.

Acta Neuropathol 2020 02 4;139(2):259-271. Epub 2019 Dec 4.

Department of Oncology, St Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN, USA.

Pineoblastoma is a rare embryonal tumor of childhood that is conventionally treated with high-dose craniospinal irradiation (CSI). Multi-dimensional molecular evaluation of pineoblastoma and associated intertumoral heterogeneity is lacking. Herein, we report outcomes and molecular features of children with pineoblastoma from two multi-center, risk-adapted trials (SJMB03 for patients ≥ 3 years; SJYC07 for patients < 3 years) complemented by a non-protocol institutional cohort. Read More

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http://dx.doi.org/10.1007/s00401-019-02106-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7065912PMC
February 2020

Melatonin: an anti-tumor agent for osteosarcoma.

Cancer Cell Int 2019 29;19:319. Epub 2019 Nov 29.

2Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Islamic Republic of Iran.

Osteosarcoma is the most common bone tumors which consisted of malignant mesenchymal cells generating osteoid and immature bone. It has been showed that osteosarcoma is common in children and adolescents and shows high mortality rate. A variety of therapeutic approaches (i. Read More

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http://dx.doi.org/10.1186/s12935-019-1044-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6884844PMC
November 2019

Molecular subgrouping of primary pineal parenchymal tumors reveals distinct subtypes correlated with clinical parameters and genetic alterations.

Acta Neuropathol 2020 02 25;139(2):243-257. Epub 2019 Nov 25.

Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.

Tumors of the pineal region comprise several different entities with distinct clinical and histopathological features. Whereas some entities predominantly affect adults, pineoblastoma (PB) constitutes a highly aggressive malignancy of childhood with a poor outcome. PBs mainly arise sporadically, but may also occur in the context of cancer predisposition syndromes including DICER1 and RB1 germline mutation. Read More

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http://dx.doi.org/10.1007/s00401-019-02101-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7275775PMC
February 2020

Desmoplastic myxoid tumor, SMARCB1-mutant: clinical, histopathological and molecular characterization of a pineal region tumor encountered in adolescents and adults.

Acta Neuropathol 2020 02 16;139(2):277-286. Epub 2019 Nov 16.

Institute of Neuropathology, University Hospital Münster, Pottkamp 2, Münster, Germany.

Atypical teratoid/rhabdoid tumor (ATRT) is a highly malignant brain tumor predominantly occurring in infants. Mutations of the SMARCB1 gene are the characteristic genetic lesion. SMARCB1-mutant tumors in adolescents and adults are rare and may show uncommon histopathological and clinical features. Read More

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http://dx.doi.org/10.1007/s00401-019-02094-wDOI Listing
February 2020