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    Fine-needle aspiration cytology in primary cutaneous tumors.
    Diagn Cytopathol 2017 May 4. Epub 2017 May 4.
    Department of Cytology and Gynecologic Pathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
    Background: Fine-needle aspiration biopsy (FNAB) is occasionally used in the evaluation of primary skin tumors. However, in routine evaluation of any soft tissue swelling we encounter the cases of skin lesions. It is essential to know FNAB features of skin lesions. Read More

    Metastatic endometrial endometrioid carcinoma mimicking pilomatrixoma of the distal vagina.
    BMJ Case Rep 2017 Jan 27;2017. Epub 2017 Jan 27.
    Department of Gynaecology, Karolinska Universitetssjukhuset, Stockholm, Sweden.
    Endometrioid carcinoma with a prominent squamous component has the ability to mimic pilomatrixoma. One previous case is documented of cutaneous metastasis in the upper limb derived from ovarian endometrioid carcinoma mimicking pilomatrixoma. Here, we describe a case of metastasis of endometrial endometrioid carcinoma in the distal vagina, treated with radiotherapy and later resected. Read More

    Diagnostic imaging of benign and malignant neck masses in children-a pictorial review.
    Quant Imaging Med Surg 2016 Oct;6(5):591-604
    Department of Radiology, Alder Hey Children's Hospital, Liverpool, UK.
    Neck masses are frequently encountered in pediatric medicine, and can present a diagnostic dilemma for the clinicians involved. There are several means by which neck masses in children can be subdivided, for example by age at presentation, anatomical location including compartments and fascia of the neck, their classical appearance when imaged, or by etiology. When imaging children the clinicians must be mindful of radiation exposure and as such ultrasound (US) is often attempted first. Read More

    Pilomatricoma Associated with Kabuki Syndrome.
    Pediatr Dermatol 2017 Jan 25;34(1):e26-e27. Epub 2016 Oct 25.
    Division of Dermatology, Department of Paediatrics, Centre Hospitalier Universitaire Sainte-Justine, Université de Montreal, Montreal, Canada.
    We report three cases of pilomatricomas associated with Kabuki syndrome (KS), supporting the hypothesis proposed of an association between pilomatricomas and KS and suggesting a noncoincidental association, because the Wnt pathway mutations involved could affect both morphogenesis and tumorigenesis in these patients. Read More

    Metastatic Malignant Pilomatrixoma in an 8-Year-Old Girl Misdiagnosed as a Recurrent Pilomatrixoma.
    Am J Dermatopathol 2017 Mar;39(3):e41-e43
    *Fundación Universitaria de Ciencias de la Salud, Bogotá, Colombia; and Departments of † Dermatology, and ‡Pathology, Hospital de San José, Bogotá, Colombia.
    Malignant pilomatrixoma or pilomatrix carcinoma is a rare, locally aggressive malignant neoplasm, derived from the hair follicle with a high propensity for local recurrence. Only a few cases of metastatic pilomatrixoma have been described in the literature. Till date, only 17 cases have been reported in the English-language medical literature, most commonly occurring associated with local recurrence in adults. Read More

    [Pilomatricoma: a study of 22 cases].
    Pan Afr Med J 2016 28;23:254. Epub 2016 Apr 28.
    Service de Dermatologie CHU Ibn Rochd, Casablanca, Maroc.
    Pilomatricoma is a common and benign skin tumor of childhood arising from the hair follicle matrix. It is an often misunderstood adnexal tumor, confused with other skin lesions. The most common sites of pilomatricome are the head and the neck. Read More

    Pilomatrixoma of the breast in a patient with type 1 myotonic dystrophy: successful surgical approach.
    J Biol Regul Homeost Agents 2016 Apr-Jun;30(2 Suppl 2):1-6
    Department of Human Pathology; University Hospital of Messina, Messina, Italy.
    Malherbe’s calcifying epithelioma is an uncommon cutaneous tumour that originates from the matrix cells of hair follicle. It was initially described by Malherbe as a benign calcifying epithelioma. Several ultra-structural and electron-microscopic studies later demonstrated its origin from matrix cells and the term pilomatrixoma was introduced. Read More

    Review of pediatric head and neck pilomatrixoma.
    Int J Pediatr Otorhinolaryngol 2016 Jun 28;85:148-53. Epub 2016 Mar 28.
    Department of Otolaryngology-Head and Neck Surgery, The Montreal Children's Hospital, McGill University Health Centre, Montreal, Quebec, Canada. Electronic address:
    Introduction: Pilomatrixoma is a benign skin tumor, which is commonly found in the head and neck region. It usually presents as an isolated lesion and rarely undergoes malignant transformation. It is not uncommon for these tumors to be misdiagnosed. Read More

    IL-8, IL-8RA (CXCR1) and IL-8RB (CXCR2) expression in pilomatricoma.
    Rom J Morphol Embryol 2016 ;57(1):59-64
    Department of Immunology, "Grigore T. Popa" University of Medicine and Pharmacy, Iassy, Romania;
    Pilomatricoma is a rare benign tumor of the hair follicle matrix cells, which associates during its evolution a foreign body-like inflammatory process. We have investigated three such tumors, two of them displaying a rather poor stroma, while the third was distinctive due to its stroma and large numbers of inflammatory cells infiltrating the tumor. The analysis of IL-8 (interleukin-8), CXCR1 (IL-8RA - IL-8 receptor alpha) and CXCR2 (IL-8RB - IL-8 receptor beta) expression showed that these molecules are present not only in many different types of inflammatory and endothelial cells, but also in several tumor basaloid, transitional and even few ghost cells. Read More

    Concomitant cetuximab and radiation therapy: A possible promising strategy for locally advanced inoperable non-melanoma skin carcinomas.
    Mol Clin Oncol 2016 Apr 27;4(4):467-471. Epub 2016 Jan 27.
    Oncology Unit, 'San Giovanni di Dio' Hospital, A.S.L. Napoli 2 Nord, I-80027 Frattamaggiore (NA), Italy.
    Non-melanoma skin cancers (NMSCs) include a heterogeneous group of malignancies arising from the epidermis, comprising squamous cell carcinoma (SCC), basal cell carcinoma (BCC), Merkel cell carcinoma and more rare entities, including malignant pilomatrixoma and sebaceous gland tumours. The treatment of early disease depends primarily on surgery. In addition, certain patients present with extensive local invasion or metastasis, which renders these tumours surgically unresectable. Read More

    Metachronous T-Lymphoblastic Lymphoma and Burkitt Lymphoma in a Child With Constitutional Mismatch Repair Deficiency Syndrome.
    Pediatr Blood Cancer 2016 08 1;63(8):1454-6. Epub 2016 Apr 1.
    Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee.
    Constitutional mismatch repair deficiency (CMMRD) is a cancer predisposition syndrome associated with a high risk of developing early-onset malignancies of the blood, brain, and intestinal tract. We present the case of a patient with T-lymphoblastic lymphoma at the age of 3 years, followed by Burkitt lymphoma 10 years later. This patient also exhibited numerous nonmalignant findings including café au lait spots, lipomas, bilateral renal nodules, a nonossifying fibroma, multiple colonic adenomas, and a rapidly enlarging pilomatrixoma. Read More

    Metastatic pilomatrix carcinoma: Not so rare after all? A case report and review of the literature.
    Ear Nose Throat J 2016 Mar;95(3):117-20
    Department of General Surgery, Royal Brisbane and Women's Hospital, Herston, Queensland, Australia.
    Pilomatrixoma is a slowly growing benign tumor of the dermal hair cells. Metastatic disease is exceptionally rare. Pilomatrixoma can occur at any age, but most patients are older than 40 years at presentation. Read More

    Giant molluscum contagiosum presenting as lid neoplasm in an immunocompetent child.
    Dermatol Online J 2016 Jan 15;22(1). Epub 2016 Jan 15.
    Medical Research Foundation, Sankara Nethralaya, Chennai.
    A three-year-old boy presented to our oculoplastic clinic with complaints of painless gradually increasing right upper lid mass for the last 6 months. On examination a firm mass measuring roughly 1x1 cm was present on the upper lid. The mass was non tender with fine superficial vessels running over it. Read More

    Pilomatrix carcinoma of the vulva.
    Gynecol Oncol Rep 2016 Jan 19;15:9-11. Epub 2015 Dec 19.
    Rutgers-Cancer Institute of New Jersey, Rutgers-Robert Wood Johnson Medical School, Department of Obstetrics, Gynecology and Reproductive Sciences, Division of Gynecologic Oncology, 195 Little Albany Street, New Brunswick, NJ 08903, United States.
    Background: Pilomatrix carcinomas are rare, frequently occurring in older male patients. We report a case of vulvar pilomatrix carcinoma in a 30-year-old woman, the second known reported case occurring on the external genitalia.

    Case: A 30-year-old female originally presented at an outside institution for the management of an asymptomatic vulvar mass that was biopsied and read as invasive squamous cell carcinoma. Read More

    Complicated Giant Pilomatrixoma of the Parotid Region.
    J Maxillofac Oral Surg 2016 Mar 24;15(1):111-5. Epub 2014 Dec 24.
    Pathology Department, Dr. Lutfi Kirdar Kartal Education and Research Hospital, Istanbul, Turkey.
    Objective: Pilomatrixoma (calcifying epithelioma of Malherbe) is a benign soft tissue tumour arising from dermis or subcutaneous tissue which should be considered in differential diagnosis of preauricular lesions especially when skin fixation is present.

    Case Report: Twenty-three year old male referred to our clinic with complaint of left preauricular swelling over 18 months which enlarged and became painful in the last 2 months. Because the lesion showed signs of infection, surgery was planned after medical therapy was completed. Read More

    Activation of the OVOL1-OVOL2 Axis in the Hair Bulb and in Pilomatricoma.
    Am J Pathol 2016 Apr 9;186(4):1036-43. Epub 2016 Feb 9.
    Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
    OVOL1 and OVOL2, ubiquitously conserved genes encoding C2H2 zinc finger transcription factors in mammals, control epithelial cell proliferation, and differentiation, including those in skin. OVOL1 and OVOL2 expression is coordinately mediated via the Wnt signaling pathway, and OVOL1 negatively regulates OVOL2 expression in a transcriptional manner. Our previous study of OVOL1 expression in human skin revealed that OVOL1 is preferentially expressed in the inner root sheath of the hair follicle. Read More

    Bleeding Papule on the Scapula.
    Am J Dermatopathol 2016 Feb;38(2):131-2 , 158-61
    *Department of Dermatology, Complejo Hospitalario Universitario Insular Materno Infantil, Las Palmas de Gran Canaria, Spain; †Department of Dermatology, Fundación Jiménez Díaz, Madrid, Spain; and ‡Department of Pathology, Complejo Hospitalario Universitario Insular Materno Infantil, Las Palmas de Gran Canaria, Spain.

    Uncommon benign tumour of the skin: infraorbital pilomatricoma.
    BMJ Case Rep 2016 Jan 6;2016. Epub 2016 Jan 6.
    Department of Pathology, Istanbul University, Istanbul, Turkey.
    Pilomatricoma is a relatively rare tumour of the skin derived from primitive basal cells of epidermis that differentiate into hair matrix cells. It comprises approximately 1% of all benign skin tumours. The most common sites for pilomatricomas are the head, neck and upper extremities. Read More

    Malignant Melanocytic Matricoma: A Report of 2 Cases and Review of the Literature.
    Am J Dermatopathol 2016 Jan;38(1):33-8
    *Department of Anatomical Pathology, PathWest Laboratory Medicine, QEII Medical Centre, Perth, Australia; †Histology Unit, Western Diagnostic Pathology, Perth, Australia; and ‡School of Pathology and Laboratory Medicine, University of Western Australia, Perth, Australia.
    Background: To describe 2 cases of melanocytic matricoma with malignant histological features and systematically review previously reported cases of malignant melanocytic matricoma.

    Methods: Two cases of malignant melanocytic matricoma were identified from the practice of the authors. Additional 3 cases were identified in the literature. Read More

    Concurrent Pilomatrix Carcinoma and Diffuse Large B-Cell Lymphoma.
    Oncol Ther 2016 20;4(1):129-134. Epub 2016 May 20.
    Plastic Surgery Department, Hospital 12 de Octubre, Madrid, Spain.
    Pilomatrix carcinoma is a rare cutaneous tumor derived from follicular matrix cells. It may arise de novo or from a malignant transformation of a pilomatrixoma. The latter process has been associated with impaired immune system surveillance of the host caused by UV radiation or the onset of an underlying malignant neoplasm. Read More

    Pilomatricoma of Childhood: A Common Pathologic Diagnosis Yet a Rare Radiologic One.
    AJR Am J Roentgenol 2016 Jan;206(1):182-8
    4 Department of Radiology, University of Texas Southwestern Medical Center and Children's Health, 1935 Medical District Dr, Dallas, TX 75235.
    Objective: The purposes of this study were to determine the accuracy of radiology reports in the diagnosis of pediatric pilomatricoma and to describe the characteristic imaging findings in a large cohort.

    Materials And Methods: Query of a pathology database between January 2009 and February 2014 yielded 623 specimens from 596 patients. Seventy-four patients (41 girls, 33 boys; mean age, 8. Read More

    [Diagnostic value of CT for head and neck pilomatricoma].
    Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2015 Jul;50(7):594-6
    Department of Radiology, First Affiliated Hospital of Anhui Medical University, Hefei 230022, China; Email:
    Objective: To evaluate the CT and pathological features of head and neck pilomatricoma.

    Methods: We retrospectively analyzed the CT findings of 13 patients with head and neck pilomatricoma which were pathologically confirmed. Of them 7 patients received plain CT, 2 patients received contrast-enhancement, and 4 patients received plain CT plus contrast-enhancement. Read More

    DICER1 syndrome can mimic different genetic tumor predispositions.
    Cancer Lett 2016 Jan 11;370(2):275-8. Epub 2015 Nov 11.
    Institute of Human Genetics, University Hospital, University of Munich, Munich, Germany. Electronic address:
    DICER1, a RNAse endonuclease involved in the processing of siRNA and microRNA, is known to play a pivotal role in the post-transcriptional regulation of gene expression. Germ line mutations in the DICER1 gene increase the risk for different types of tumors. At present, DICER1 syndrome is an established, though not well defined, member of the group of genetic tumor predisposition syndromes. Read More

    Shadow cell differentiation in endometrioid carcinomas of the uterus. Its frequent occurrence and beta-catenin expression.
    Cesk Patol 2015 ;51(3):123-6
    Shadow cell differentiation (SCD) is typical for pilomatrixoma and related follicular tumors of the skin. However, it has been described rarely in some extra-cutaneous lesions such as gonadal teratoma, craniopharyngioma, odontogenic cyst, and in rare visceral carcinomas (lung, bladder, gallbladder, uterus, ovary, and colon). In our practice, we have noticed that the occurrence of shadow cells is not very rare in endometrioid carcinoma (EC) of the uterus. Read More

    A rare variant of pilomatricoma: pseudobullous pilomatricoma.
    Acta Dermatovenerol Alp Pannonica Adriat 2015 ;24(3):59-60
    Department of Dermatology, Ahi Evran University, Kırşehir, Turkey.
    Pilomatricoma (PM; calcifying epithelioma of Malherbe) is a benign tumor originating from the matrix of the hair follicles. Clinical types of the tumor are familial, perforating, multinodular, exophytic, anetodermic, and giant PM. The bullous type is seen only in 3 to 6% of cases. Read More

    Proliferating pilomatricoma--Case report.
    An Bras Dermatol 2015 May-Jun;90(3 Suppl 1):94-6
    Universidade Estadual de Londrina, Paraná, PR, BR.
    Proliferating pilomatricoma is proliferative, rare tumor variant of pilomatricoma. It is a benign neoplasm of hair matrix that can have potentially involve local recurrence. We report the case of a 60-year-old man who presented an asymptomatic nodule on the scalp. Read More

    Matrical Carcinoma With Melanocytic Proliferation and Prominent Squamoid Whorls.
    Am J Dermatopathol 2016 Jan;38(1):e11-4
    Departments of *Pathology and †Dermatology, Jackson Memorial Hospital, University of Miami Miller School of Medicine, Miami, FL.
    Matrical carcinoma (pilomatrix carcinoma) is a rare follicular low-grade malignancy with matrical differentiation. A pigmented variant with admixed dendritic melanocytes is exceedingly rare with only 7 cases reported in the literature. The diagnosis of malignancy can be difficult to establish. Read More

    MR imaging findings of pilomatricomas: a radiological-pathological correlation.
    Acta Radiol 2016 Jun 7;57(6):726-32. Epub 2015 Aug 7.
    Department of Pathology, Gifu University School of Medicine, Gifu, Japan.
    Background: Magnetic resonance imaging (MRI) findings of pilomatricomas have yet to be determined.

    Purpose: To assess the correlation between MRI and pathological findings of pilomatricomas.

    Material And Methods: MR images were obtained on patients with histologically proven pilomatricomas using a 1. Read More

    A review of eight unusual pediatric skin and soft-tissue lesions: Diagnosis, workup, and treatment.
    J Plast Reconstr Aesthet Surg 2015 Dec 6;68(12):1637-46. Epub 2015 Jul 6.
    Department of Plastic Surgery, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, USA. Electronic address:
    The spectrum of clinical presentations in pediatric skin and soft-tissue lesions often makes diagnosis challenging. Delays in diagnosis and subsequent treatment can be life threatening, and they can subject patients to more complicated reconstruction. This retrospective case series reviews the presentation, management, and current literature on eight pediatric skin and soft-tissue lesions. Read More

    The diagnostic value of ultrasonography with 5-15-MHz probes in benign subcutaneous lesions.
    Int J Dermatol 2015 Nov 3;54(11):e469-75. Epub 2015 Jul 3.
    Department of Dermatology, Seoul National University Boramae Hospital, Seoul, South Korea.
    Background: Ultrasonography (US) has recently proved to be useful in diagnostic dermatology. It is convenient to use, completely safe, and provides valuable information.

    Objective: This study was performed to compare the diagnostic accuracy of US with that of clinical diagnosis in patients with benign subcutaneous lesions. Read More

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