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    1 OF 17

    Endoscopic Excision of Benign Facial Masses in Children: A Review of Outcomes.
    J Laparoendosc Adv Surg Tech A 2018 May 15;28(5):617-621. Epub 2018 Feb 15.
    2 Division of Pediatric Surgery, Lucile Packard Children's Hospital, Stanford University Medical Center , Stanford, California.
    Purpose: Benign masses of the eyebrow and forehead are common in pediatric patients and can result in facial asymmetry, discomfort, or super-infection. Excision is classically conducted via an incision directly over the mass, which can produce sub-optimal cosmesis. Recently, an endoscopic approach using pediatric brow-lift equipment has been adopted. Read More

    Primary cutaneous anaplastic large-cell lymphoma: A case report.
    Medicine (Baltimore) 2018 Jan;97(4):e9645
    Rationale: Primary cutaneous anaplastic large-cell lymphoma (C-ALCL) is a rare cancer belonging to the group of primary T-cell lymphoproliferative diseases. C-ALCL is characterized by the presence of single or multiple ulcerated lesions on the skin's surface.

    Patient Concerns: This is the case of a 73-year-old man who reported to the Clinic of Cranio-Maxillofacial and Oral Surgery and Implantology, Medical University of Warsaw, owing to a skin tumor in the right parotideomasseteric region, initially diagnosed as discoid lupus erythematosus. Read More

    Pilomatrix Carcinoma Masquerading as Breast Carcinoma.
    Indian J Med Paediatr Oncol 2017 Jul-Sep;38(3):367-370
    Department of Pathology, Tata Memorial Centre, Mumbai, Maharashtra, India.
    Pilomatrix carcinoma is an exceedingly rare skin adnexal neoplasm derived from piliferous follicles, usually occurring in the head and neck region. Localization of this tumor in the breast is a rarity. We now report an unusual case of a 49-year-old female who presented with a palpable mass in the left breast for 2 years. Read More

    Pilomatrixoma of the Neck/Shoulder Region Mimicking a Rapidly Growing Neoplasm of Peripheral Nerve Sheath Origin in Neurofibromatosis Type 1.
    Anticancer Res 2017 12;37(12):6907-6910
    Institute of Neuropathology, Eppendorf University Hospital, University of Hamburg, Hamburg, Germany.
    Neurofibromatosis type 1 (NF1) is an autosomal dominant hereditary disorder. Neurofibroma is the most common neoplasm of this disease. This lesion is characterized by circumscribed soft or knotty skin tumors derived from peripheral nerve sheath cells. Read More

    Colossal pilomatrixoma.
    Ann R Coll Surg Engl 2018 Feb 28;100(2):e38-e40. Epub 2017 Nov 28.
    Division of Pediatric Surgery, UCSF Benioff Children's Hospital Oakland, CA United States.
    We describe the largest reported case of pilomatrixoma in the literature. While pilomatrixomas typically present as small soft-tissue nodules of the head, neck and upper extremities, they can also present as much larger masses in atypical locations. When they present in their usual size, pilomatrixomas have typical imaging features and can be correctly diagnosed with imaging studies before histological confirmation. Read More

    [Pilomatrixoma in a tattoo].
    Hautarzt 2018 Mar;69(3):242-244
    Klinik für Dermatologie, Allergologie und Phlebologie, Klinikum Bremerhaven Reinkenheide, Postbrookstr. 103, 27574, Bremerhaven, Deutschland.
    A 31-year-old man developed a fast-growing tumor on the right upper arm within a black tattoo, which could be classified histologically as pilomatrixoma. While the age of the patient and the rapid growth of the tumor cannot be regarded as typical findings of pilomatrixomas, the localization on the upper arm is one of their predilection points. Despite the wide spread use of tattoos in the last few decades, tumor development in tattooed skin is rarely reported. Read More

    Periorbital lesions misdiagnosed as dermoid cysts.
    J AAPOS 2017 Dec 28;21(6):509-511. Epub 2017 Oct 28.
    Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Kingdom of Saudi Arabia. Electronic address:
    Several periorbital lesions can be clinically misdiagnosed as dermoid cyst. We retrospectively reviewed the histopathological findings for 97 biopsied periorbital lesions with a clinical diagnosis of dermoid cyst from January 2006 to July 2016 at a single center and identified 5 cases that were eventually found to have been misdiagnosed. The main presenting symptom was a long-standing mobile painless mass with intact overlying skin below the medial aspect of the brow in 4 patients and below the center of the brow in 1 patient. Read More

    Pilomatrix carcinoma: 12-year experience and review of the literature.
    J Cutan Pathol 2018 Jan 18;45(1):33-38. Epub 2017 Oct 18.
    Plastic and Reconstructive Surgery Department, St John's Hospital, Livingston, UK.
    Pilomatrix carcinoma is a rare, locally aggressive tumor with a tendency to recur. Distant metastases have been reported, with pulmonary lesions being the most frequent manifestation. Similar to pilomatrixoma, pilomatrix carcinoma typically presents as a nontender, firm dermal swelling and is found most commonly in the head and neck region. Read More

    Multiple pilomatrixomas in a survivor of WNT-activated medulloblastoma leading to the discovery of a germline APC mutation and the diagnosis of familial adenomatous polyposis.
    Pediatr Blood Cancer 2018 Jan 9;65(1). Epub 2017 Aug 9.
    Department of Hematology-Oncology, Children's Minnesota, Minneapolis, Minnesota.
    Because children diagnosed with WNT-activated medulloblastoma have a 10-year overall survival rate of 95%, active long-term follow-up is critically important in reducing mortality from other causes. Here, we describe an 11-year-old adopted female who developed multiple pilomatrixomas 3 years after diagnosis of WNT-activated medulloblastoma, an unusual finding that prompted deeper clinical investigation. A heterozygous germline APC gene mutation was discovered, consistent with familial adenomatous polyposis. Read More

    Pilomatrixoma located on the cruris: an uncommon localization.
    J Surg Case Rep 2017 Jul 4;2017(7):rjx114. Epub 2017 Jul 4.
    Ankara Oncology Training and Research Hospital, Department of Orthopaedics and Traumatology, Ankara, Turkey.
    Pilomatrixoma is a benign tumor of hair follicle matrix cells. The majority of all pilomatrixomas were reported to affect the head-neck region and rarely the upper extremity. We present a case of left-leg pilomatrixoma, which is a extremely rare localization, in a 10-year-old boy. Read More

    Calcifying epithelioma of malherbe (Pilomatrixoma): Clinical and sonographic features.
    J Clin Ultrasound 2018 Jan 5;46(1):3-7. Epub 2017 Jul 5.
    Department of Ultrasound, The first affiliated hospital of Wenzhou Medical University, WenZhou, 325000, Zhejiang Province, China.
    Purpose: The purpose of this study was to describe the clinical and sonographic features of calcifying epitheliomas (pilomatrixomas).

    Methods: We retrospectively reviewed the clinical data and sonographic appearances of 59 cases of calcifying epitheliomas in 58 patients that were confirmed pathologically.

    Results: The mean age of the patients was 26 years (range, 5-69 years) and the female-to-male ratio was 1. Read More

    Genetic basis of calcifying cystic odontogenic tumors.
    PLoS One 2017 28;12(6):e0180224. Epub 2017 Jun 28.
    Department of Oral Pathology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.
    Calcifying cystic odontogenic tumors (CCOTs) are benign cystic tumors that form abnormally keratinized ghost cells. Mutations in CTNNB1, which encodes beta-catenin, have been implicated in the development of these tumors, but a causal relationship has not been definitively established. Thus, mutational hot spots in 50 cancer genes were examined by targeted next-generation sequencing in 11 samples of CCOT. Read More

    [The diagnosis of pilomatrixoma in children is not as easy as it may seem. A review of 126 cases].
    Cir Pediatr 2017 Jan 25;30(1):46-49. Epub 2017 Jan 25.
    Hospital Universitario Miguel Servet. Zaragoza.
    Objective: To describe our experience with pilomatrixomas, clinical presentation, clinical accuracy, associated diseases, and surgical treatment.

    Methods: A retrospective review of patients with a pathology report of an excised pilomatrixoma between 2011 and 2014. Data regarding gender, age of intervention, number of masses, size, location, and preoperative clinical diagnosis, pathology report, recurrences, and associated diseases were collected. Read More

    Fine-needle aspiration cytology in primary cutaneous tumors.
    Diagn Cytopathol 2017 Aug 4;45(8):681-688. Epub 2017 May 4.
    Department of Cytology and Gynecologic Pathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
    Background: Fine-needle aspiration biopsy (FNAB) is occasionally used in the evaluation of primary skin tumors. However, in routine evaluation of any soft tissue swelling we encounter the cases of skin lesions. It is essential to know FNAB features of skin lesions. Read More

    Basal Cell Carcinoma With Matrical Differentiation: Clinicopathologic, Immunohistochemical, and Molecular Biological Study of 22 Cases.
    Am J Surg Pathol 2017 Jun;41(6):738-749
    *Sikl's Department of Pathology, Medical Faculty in Pilsen, Charles University in Prague, Pilsen, Czech Republic ‡Bioptical Laboratory ∥Biomedical Center, Faculty of Medicine in Pilsen and Charles University Medical Faculty Hospital, Pilsen ¶Agel Laboratory of Pathology, Novy Jicin, Czech Republic †Department of Histopathology, Warwick Hospital, Warwick, United Kingdom §Department of Pathology, University of Nantes, Nantes, France.
    Basal cell carcinoma (BCC) with matrical differentiation is a fairly rare neoplasm, with about 30 cases documented mainly as isolated case reports. We studied a series of this neoplasm, including cases with an atypical matrical component, a hitherto unreported feature. Lesions coded as BCC with matrical differentiation were reviewed; 22 cases were included. Read More

    Anetodermic pilomatricoma: clinical, histopathologic, and sonographic findings.
    Dermatol Online J 2017 Mar 15;23(3). Epub 2017 Mar 15.
    Hospital Universitario de Cabueñes, Servicio de Dermatología, Gijón, Asturias, España.
    Pilomatricoma is a benign cutaneous tumor originatingfrom hair matrix cells. Anetodermic changes inthe skin overlying pilomatricomas are sometimesreported, although their precise mechanisms remainunknown. We present an unusual case of anetodermicpilomatricoma on the upper extremity of a 17-yearoldboy and report its clinical, histopathologic, andsonographic findings. Read More

    Metastatic endometrial endometrioid carcinoma mimicking pilomatrixoma of the distal vagina.
    BMJ Case Rep 2017 Jan 27;2017. Epub 2017 Jan 27.
    Department of Gynaecology, Karolinska Universitetssjukhuset, Stockholm, Sweden.
    Endometrioid carcinoma with a prominent squamous component has the ability to mimic pilomatrixoma. One previous case is documented of cutaneous metastasis in the upper limb derived from ovarian endometrioid carcinoma mimicking pilomatrixoma. Here, we describe a case of metastasis of endometrial endometrioid carcinoma in the distal vagina, treated with radiotherapy and later resected. Read More

    Diagnostic imaging of benign and malignant neck masses in children-a pictorial review.
    Quant Imaging Med Surg 2016 Oct;6(5):591-604
    Department of Radiology, Alder Hey Children's Hospital, Liverpool, UK.
    Neck masses are frequently encountered in pediatric medicine, and can present a diagnostic dilemma for the clinicians involved. There are several means by which neck masses in children can be subdivided, for example by age at presentation, anatomical location including compartments and fascia of the neck, their classical appearance when imaged, or by etiology. When imaging children the clinicians must be mindful of radiation exposure and as such ultrasound (US) is often attempted first. Read More

    IMAGING DIAGNOSIS-NUCLEAR SCINTIGRAPHIC, RADIOLOGICAL, AND PATHOLOGIC CHARACTERISTICS OF METASTATIC PILOMATRICOMA IN A DOG.
    Vet Radiol Ultrasound 2016 Nov 9;57(6):E58-E62. Epub 2016 Feb 9.
    Department of Comparative Pathobiology, College of Veterinary Medicine, Purdue University, West Lafayette, IN, 47907.
    A 6-year-old castrated Goldendoodle dog was presented for left-sided lameness of 3 weeks' duration. Focal, moderate to marked increased Tc-methylene diphosphonate ( Tc-MDP) uptake was detected in the right caudal lung lobe, caudal angle of the left scapula, and the distal aspect of the left femur with whole body bone phase scintigraphy. Radiographs identified a well-circumscribed, oval-shaped soft tissue opaque mass in the right caudal lung lobe; a suspect oval-shaped osteolytic lesion in the proximal third of the left scapula; and an osteolytic lesion in the distal aspect of the left femur. Read More

    Pilomatricoma Associated with Kabuki Syndrome.
    Pediatr Dermatol 2017 Jan 25;34(1):e26-e27. Epub 2016 Oct 25.
    Division of Dermatology, Department of Paediatrics, Centre Hospitalier Universitaire Sainte-Justine, Université de Montreal, Montreal, Canada.
    We report three cases of pilomatricomas associated with Kabuki syndrome (KS), supporting the hypothesis proposed of an association between pilomatricomas and KS and suggesting a noncoincidental association, because the Wnt pathway mutations involved could affect both morphogenesis and tumorigenesis in these patients. Read More

    [Clinical and pathological analysis of ocular tumors in 504 children cases].
    Zhonghua Yan Ke Za Zhi 2016 Oct;52(10):764-768
    Tianjin Eye Hospital and Institute, Clinical College of Ophthalmology of Tianjin Medical University, Tianjin Key Laboratory of Ophthalmology and Vision Science, Tianjin 300020, China.
    To analyze the clinical features and pathological classification of chlidren's ocular tumors. Retrospective case series study. Five hundred and four cases (506 eyes) of ocular tumor with biopsy-proven in children below 14 years old between January 2002 and December 2014 from Tianjin Eye Hospital were performed to retrospectively investigated the lesion location, clinical features and histopathologic classification of these lesions. Read More

    Metastatic Malignant Pilomatrixoma in an 8-Year-Old Girl Misdiagnosed as a Recurrent Pilomatrixoma.
    Am J Dermatopathol 2017 Mar;39(3):e41-e43
    *Fundación Universitaria de Ciencias de la Salud, Bogotá, Colombia; and Departments of † Dermatology, and ‡Pathology, Hospital de San José, Bogotá, Colombia.
    Malignant pilomatrixoma or pilomatrix carcinoma is a rare, locally aggressive malignant neoplasm, derived from the hair follicle with a high propensity for local recurrence. Only a few cases of metastatic pilomatrixoma have been described in the literature. Till date, only 17 cases have been reported in the English-language medical literature, most commonly occurring associated with local recurrence in adults. Read More

    A novel germline POLE mutation causes an early onset cancer prone syndrome mimicking constitutional mismatch repair deficiency.
    Fam Cancer 2017 01;16(1):67-71
    Pediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany.
    In a 14-year-old boy with polyposis and rectosigmoid carcinoma, we identified a novel POLE germline mutation, p.(Val411Leu), previously found as recurrent somatic mutation in 'ultramutated' sporadic cancers. This is the youngest reported cancer patient with polymerase proofreading-associated polyposis indicating that POLE mutation p. Read More

    [Pilomatricoma: a study of 22 cases].
    Pan Afr Med J 2016 28;23:254. Epub 2016 Apr 28.
    Service de Dermatologie CHU Ibn Rochd, Casablanca, Maroc.
    Pilomatricoma is a common and benign skin tumor of childhood arising from the hair follicle matrix. It is an often misunderstood adnexal tumor, confused with other skin lesions. The most common sites of pilomatricome are the head and the neck. Read More

    Cluster Sampling Bias in Government-Sponsored Evaluations: A Correlational Study of Employment and Welfare Pilots in England.
    PLoS One 2016 9;11(8):e0160652. Epub 2016 Aug 9.
    London School of Economics and Political Science, London, United Kingdom.
    For pilot or experimental employment programme results to apply beyond their test bed, researchers must select 'clusters' (i.e. the job centres delivering the new intervention) that are reasonably representative of the whole territory. Read More

    Pilomatrixoma of the breast in a patient with type 1 myotonic dystrophy: successful surgical approach.
    J Biol Regul Homeost Agents 2016 Apr-Jun;30(2 Suppl 2):1-6
    Department of Human Pathology; University Hospital of Messina, Messina, Italy.
    Malherbe’s calcifying epithelioma is an uncommon cutaneous tumour that originates from the matrix cells of hair follicle. It was initially described by Malherbe as a benign calcifying epithelioma. Several ultra-structural and electron-microscopic studies later demonstrated its origin from matrix cells and the term pilomatrixoma was introduced. Read More

    Review of pediatric head and neck pilomatrixoma.
    Int J Pediatr Otorhinolaryngol 2016 Jun 28;85:148-53. Epub 2016 Mar 28.
    Department of Otolaryngology-Head and Neck Surgery, The Montreal Children's Hospital, McGill University Health Centre, Montreal, Quebec, Canada. Electronic address:
    Introduction: Pilomatrixoma is a benign skin tumor, which is commonly found in the head and neck region. It usually presents as an isolated lesion and rarely undergoes malignant transformation. It is not uncommon for these tumors to be misdiagnosed. Read More

    IL-8, IL-8RA (CXCR1) and IL-8RB (CXCR2) expression in pilomatricoma.
    Rom J Morphol Embryol 2016 ;57(1):59-64
    Department of Immunology, "Grigore T. Popa" University of Medicine and Pharmacy, Iassy, Romania;
    Pilomatricoma is a rare benign tumor of the hair follicle matrix cells, which associates during its evolution a foreign body-like inflammatory process. We have investigated three such tumors, two of them displaying a rather poor stroma, while the third was distinctive due to its stroma and large numbers of inflammatory cells infiltrating the tumor. The analysis of IL-8 (interleukin-8), CXCR1 (IL-8RA - IL-8 receptor alpha) and CXCR2 (IL-8RB - IL-8 receptor beta) expression showed that these molecules are present not only in many different types of inflammatory and endothelial cells, but also in several tumor basaloid, transitional and even few ghost cells. Read More

    Concomitant cetuximab and radiation therapy: A possible promising strategy for locally advanced inoperable non-melanoma skin carcinomas.
    Mol Clin Oncol 2016 Apr 27;4(4):467-471. Epub 2016 Jan 27.
    Oncology Unit, 'San Giovanni di Dio' Hospital, A.S.L. Napoli 2 Nord, I-80027 Frattamaggiore (NA), Italy.
    Non-melanoma skin cancers (NMSCs) include a heterogeneous group of malignancies arising from the epidermis, comprising squamous cell carcinoma (SCC), basal cell carcinoma (BCC), Merkel cell carcinoma and more rare entities, including malignant pilomatrixoma and sebaceous gland tumours. The treatment of early disease depends primarily on surgery. In addition, certain patients present with extensive local invasion or metastasis, which renders these tumours surgically unresectable. Read More

    Metachronous T-Lymphoblastic Lymphoma and Burkitt Lymphoma in a Child With Constitutional Mismatch Repair Deficiency Syndrome.
    Pediatr Blood Cancer 2016 08 1;63(8):1454-6. Epub 2016 Apr 1.
    Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee.
    Constitutional mismatch repair deficiency (CMMRD) is a cancer predisposition syndrome associated with a high risk of developing early-onset malignancies of the blood, brain, and intestinal tract. We present the case of a patient with T-lymphoblastic lymphoma at the age of 3 years, followed by Burkitt lymphoma 10 years later. This patient also exhibited numerous nonmalignant findings including café au lait spots, lipomas, bilateral renal nodules, a nonossifying fibroma, multiple colonic adenomas, and a rapidly enlarging pilomatrixoma. Read More

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