1,578 results match your criteria Pilar Cyst


Evaluating centralized technical assistance as an implementation strategy to improve cancer prevention and control.

Cancer Causes Control 2018 Dec 7. Epub 2018 Dec 7.

Prevention Research Center, Brown School, Washington University in St. Louis, One Brookings Drive, Campus, Box 1196, St. Louis, MO, 63130, USA.

Purpose: In 2015-2016, the Comprehensive Cancer Control National Partnership provided technical assistance workshops to support 22 cancer coalitions in increasing human papillomavirus (HPV) vaccination uptake and increasing colorectal cancer (CRC) screening in their local communities. As national efforts continue to invest in providing technical assistance, there is a current gap in understanding its use as a strategy to accelerate implementation of evidence-based interventions (EBIs) for cancer prevention. The objective of this study was to evaluate the impact of technical assistance on the participants' knowledge, attitudes, and skills for implementing EBIs in their local context and enhancing state team collaboration. Read More

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December 2018

Effects of Arachidonic and Docosohexahenoic Acid Supplementation during Gestation in Rats. Implication of Placental Oxidative Stress.

Int J Mol Sci 2018 Dec 4;19(12). Epub 2018 Dec 4.

Department of Physiology, Faculty of Medicine, University Autónoma of Madrid, 28029 Madrid, Spain.

Arachidonic and docosahexaenoic acids (ARA and DHA) are important during pregnancy. However, the effects of dietary supplementation on fetal growth and oxidative stress are inconclusive. We aimed to assess the effect of high ARA and DHA diet during rat gestation on: (1) ARA and DHA availability in plasma and placenta, (2) fetal growth, and (3) placental oxidative stress, analyzing the influence of sex. Read More

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December 2018

MicroRNA characterization in equine induced pluripotent stem cells.

PLoS One 2018 3;13(12):e0207074. Epub 2018 Dec 3.

LIAN-CONICET, Fundación FLENI, Buenos Aires, Argentina.

Cell reprogramming has been well described in mouse and human cells. The expression of specific microRNAs has demonstrated to be essential for pluripotent maintenance and cell differentiation, but not much information is available in domestic species. We aim to generate horse iPSCs, characterize them and evaluate the expression of different microRNAs (miR-302a,b,c,d, miR-205, miR-145, miR-9, miR-96, miR-125b and miR-296). Read More

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December 2018
5 Reads

[Aggresive angiomyxoma after renal transplantation].

Medicina (B Aires) 2018 ;78(6):440-442

Servicio de Oncología, Hospital Universitario Austral, Pilar, Buenos aires, Argentina.

The condition of immunosuppressed increases the risk of cancer in kidney transplant patients, as compared to the general population. The best survival of inmunosupressed patients in recent years has turned both neoplasms and cardiovascular diseases into the main causes of morbidity and mortality. We present the case of a renal transplanted patient who developed an unusual form of mesenchymal tumor such as the aggressive angiomyxoma, four years after the implant and requiring wide surgical resection. Read More

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January 2018

Nanoindentation and TEM to Study the Cavity Fate after Post-Irradiation Annealing of He Implanted EUROFER97 and EU-ODS EUROFER.

Micromachines (Basel) 2018 Nov 29;9(12). Epub 2018 Nov 29.

Centro Nacional de Microscopía Electrónica, Universidad Complutense de Madrid, 28040 Madrid, Spain.

The effect of post-helium irradiation annealing on bubbles and nanoindentation hardness of two reduced activation ferritic martensitic steels for nuclear fusion applications (EUROFER97 and EU-ODS EUROFER) has been studied. Helium-irradiated EUROFER97 and EU-ODS EUROFER were annealed at 450 °C for 100 h in an argon atmosphere. The samples were tested by nanoindentation and studied by transmission electron microscopy extracting some focused ion beam lamellae containing the whole implanted zone (≈50 µm). Read More

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November 2018

Notes on the Cultivation of Two Mixotrophic Species and Their Ciliate Prey .

Toxins (Basel) 2018 Dec 1;10(12). Epub 2018 Dec 1.

Microalgas Nocivas, Centro Oceanográfico de Vigo, IEO, Subida a Radio Faro 50, 36390 Vigo, Spain.

Kleptoplastic mixotrophic species of the genus are cultured by feeding with the ciliate , itself a kleptoplastic mixotroph, that in turn feeds on cryptophytes of the // (TPG) clade. Optimal culture media for phototrophic growth of and from the Galician Rías (northwest Spain) and culture media and cryptophyte prey for from Huelva (southwest Spain) used to feed , were investigated. Phototrophic growth rates and yields were maximal when and were grown in ammonia-containing K(-Si) medium versus f/2(-Si) or L1(-Si) media. Read More

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December 2018

Overexpression of LeNHX2 and SlSOS2 increases salt tolerance and fruit production in double transgenic tomato plants.

Plant Physiol Biochem 2018 Nov 24;135:77-86. Epub 2018 Nov 24.

Department of Biochemistry and Molecular and Cellular Biology of Plants, Estación Experimental del Zaidín, CSIC, Granada, Spain. Electronic address:

Transgenic tomato plants (Solanum lycopersicum L. cv. MicroTom) overexpressing both the K,Na/H antiporter LeNHX2 and the regulatory kinase SlSOS2 were produced by crossing transgenic homozygous lines overexpressing LeNHX2 and SlSOS2. Read More

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November 2018
2 Reads

Surveillance for Hepatocellular Carcinoma: Does the Place Where Ultrasound Is Performed Impact Its Effectiveness?

Dig Dis Sci 2018 Dec 3. Epub 2018 Dec 3.

Hepatology and Liver Transplant Unit, Facultad de Medicina, Hospital Universitario Austral, Universidad Austral, Av. Presidente Perón 1500, B1629HJ, Pilar, Buenos Aires, Argentina.

Background: Biannual ultrasound (US) is recommended as the clinical screening tool for hepatocellular carcinoma (HCC). The effectiveness of surveillance according to the place where US is performed has not been previously reported.

Aims: To compare the effectiveness of US performed in the center responsible for follow-up as opposed to US proceeding from centers other than that of follow-up. Read More

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December 2018

Systematic review and network meta-analysis of treatment for moderate-to-severe ulcerative colitis.

Int J Clin Pharm 2018 Dec 26;40(6):1411-1419. Epub 2018 Nov 26.

Health Science, Universidad San Jorge, Autovía Mudéjar, km. 299, 50830, Villanueva de Gállego, Zaragoza, Spain.

Background Biological drugs for moderate-to-severe ulcerative colitis have changed the therapeutic perspective, while small-molecule inhibitors and new promising drugs suggest new options. Aim Assess comparative efficacy and safety of biological and new small oral drugs: commercialized and under-investigation ones for patients naïve to biological drugs. Methods A systematic review was conducted to identify the randomized clinical trials phase 2 or 3, in adults with moderate-to-severe ulcerative colitis treated with biological drugs (infliximab, adalimumab, golimumab, vedolizumab and etrolizumab) or new oral small molecules (tofacitinib and ozanimod) as first line. Read More

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December 2018
3 Reads

Remedial treatment of corroded iron objects by environmental isolates.

Appl Environ Microbiol 2018 Nov 26. Epub 2018 Nov 26.

Laboratory of Microbiology, Institute of Biology, University of Neuchâtel, 2000 Neuchâtel, Switzerland

Using bacteria to transform reactive corrosion products into stable compounds represents an alternative to traditional methods employed in iron conservation. Two environmental strains (CA23 and CU5) were used to transform ferric iron corrosion products (goethite and lepidocrocite) into stable ferrous bearing minerals (vivianite and siderite). A genomic and transcriptomic approach was conducted to analyze the metabolic traits of these strains and to evaluate their pathogenic potential. Read More

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November 2018
4 Reads

Frequency, Predictors, and Prognostic Impact of Pulmonary Artery Aneurysms in Patients With Pulmonary Arterial Hypertension.

Am J Cardiol 2018 Nov 6. Epub 2018 Nov 6.

Department of Cardiology, Hospital Universitario 12 de Octubre, Madrid, Spain; CIBER de enfermedades CardioVasculares (CIBERCV), Spain. Electronic address:

Detection of pulmonary artery aneurysms (PAA) in pulmonary arterial hypertension (PAH) is increasing. We sought to determine the frequency of PAA in a PAH cohort, variables related to its development and its prognostic impact. We conducted a retrospective analysis of PAH patients who underwent a computed tomography or magnetic resonance. Read More

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November 2018

The changing epidemiology of invasive pneumococcal disease after PCV13 vaccination in a country with intermediate vaccination coverage.

Vaccine 2018 Nov 30;36(50):7744-7752. Epub 2018 Jun 30.

Agència de Salut Pública de Catalunya, Generalitat de Catalunya, Roc Boronat 81-95, 08005 Barcelona, Spain; CIBER de Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Carlos III, Monforte de Lemos, 3-5, 28029 Madrid, Spain. Electronic address:

Background: We studied the impact of 13-valent pneumococcal conjugate vaccine (PCV13) on the incidence of invasive pneumococcal disease (IPD) and serotype distribution in a region with intermediate levels of vaccination (around 64% in children aged <2 years).

Methods: Surveillance data on IPD cases reported by microbiologists participating in the Microbiological Reporting System of Catalonia during 2006-2014 were analysed. We compared estimated incidence rate (IR) ratios for serotypes included in PCV7, PCV10non7, PCV13non10 and non-PCV13 between the PCV7 (2006-2009) and PCV13 periods (2010-2014). Read More

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November 2018
1 Read

Miniaturized liquid chromatography coupled on-line to in-tube solid-phase microextraction for characterization of metallic nanoparticles using plasmonic measurements. A tutorial.

Anal Chim Acta 2019 Jan 1;1045:23-41. Epub 2018 Aug 1.

MINTOTA Research Group, Departament de Química Analítica, Facultat de Química, Universitat de València, Dr. Moliner 50, 46100, Burjassot, Valencia, Spain. Electronic address:

This tutorial aims at providing guidelines for analyzing metallic nanoparticles (NPs) and their dispersions by using methods based on miniaturized liquid chromatography with diode array detection (MinLC-DAD) and coupled on-line to in-tube solid-phase microextraction (IT-SPME). Some practical advice and considerations are given for obtaining reliable results. In addition, this work outlines the potential applications that set these methodologies apart from microscopy-related techniques, dynamic light scattering, single particle ICP-MS, capillary electrophoresis, field-flow fractionation and other chromatographic configurations, which are discussed and mainly seek to accomplish size estimation and NP separation, speciation analysis and quantification of mainly AgNPs and AuNPs. Read More

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January 2019
2 Reads

Smart composite films of nanometric thickness based on copper-iodine coordination polymers. Toward sensors.

Chem Sci 2018 Nov 23;9(41):8000-8010. Epub 2018 Aug 23.

Departamento de Química Inorgánica , Universidad Autónoma de Madrid , 28049 Madrid , Spain . Email: ; Email:

One-pot reactions between CuI and methyl or methyl 2-amino-isonicotinate give rise to the formation of two coordination polymers (CPs) based on double zig-zag CuI chains. The presence of a NH group in the isonicotinate ligand produces different supramolecular interactions affecting the Cu-Cu distances and symmetry of the CuI chains. These structural variations significantly modulate their physical properties. Read More

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November 2018
2 Reads

Extranodal extension in resected oral cavity squamous cell carcinoma: more to it than meets the eye.

Laryngoscope 2018 Nov 13. Epub 2018 Nov 13.

Department of Radiation Oncology , Tata Memorial Hospital, Mumbai, India.

Objective/hypothesis: Extranodal extension (ENE) is an independent prognosticator in head-neck Squamous cell carcinoma (SCC). All patients with ENE, however, do not behave the same, and there is a need for further risk stratification. This study evaluates the prognostic significance of various grades of ENE and the number of nodes with ENE on overall survival (OS) in oral cavity SCC (OCSCC). Read More

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November 2018
8 Reads

Dietary Intake in Population with Metabolic Syndrome: Is the Prevalence of Inadequate Intake Influenced by Geographical Area? Cross-Sectional Analysis from PREDIMED-Plus Study.

Nutrients 2018 Nov 4;10(11). Epub 2018 Nov 4.

Department of Preventive Medicine and Public Health, Medical School, University of Navarre, 31008 Pamplona, Spain.

Inadequate diet influences chronic diseases such as cardiovascular disease (CVD), the leading cause of death in Spain. CVD figures vary from one geographical region to another; this could be associated with different food choices. Our aim was to analyse the influence of geographical area on nutrient intakes among the Spanish adult population with Metabolic Syndrome (MetS). Read More

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November 2018
8 Reads

Non-enzymatic browning kinetics in sucrose-glycine aqueous and dehydrated model systems in presence of MgCl.

Food Res Int 2018 Dec 31;114:97-103. Epub 2018 Jul 31.

Universidad de Buenos Aires, Facultad de Ciencias Exactas y Naturales, Departamentos de Industrias y Química Orgánica & CONICET, C1428AOE Buenos Aires, Argentina. Electronic address:

The development of non-enzymatic browning in the presence of MgCl was evaluated in liquid and dehydrated sucrose-glycine model systems, in relation to interactions of the salt with water and/or with sucrose. In both systems, browning was accelerated by the presence of MgCl because of the increased sugar hydrolysis (ten times faster) and the reduction of water mobility (H NMR T relaxation times) caused by this salt (between 6 and 14% lower), counteracting the inhibitory effect of water on the Maillard reaction. MgCl also provoked a 40% reduction on the fluorophores quantum yield, responsible also of the fluctuations observed in the fluorescence development as a function of time after 50 h at 70 °C. Read More

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December 2018
8 Reads

Shiga Toxin-Producing Infections during Pregnancy.

Microorganisms 2018 Oct 23;6(4). Epub 2018 Oct 23.

Laboratorio de Fisiopatogenia, Instituto de Fisiología y Biofísica Bernardo Houssay (IFIBIO Houssay-CONICET), Departamento de Fisiología, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155, Buenos Aires 1121, Argentina.

Gastrointestinal infection with Shiga toxin-producing (STEC) causes diarrhea, hemorrhagic colitis, and hemolytic uremic syndrome (HUS), characterized by hemolytic anemia, thrombocytopenia and acute renal failure. The main virulence factor of STEC is Shiga toxin (Stx), which is responsible for HUS development. STEC can produce Stx type 1 and/or 2 (Stx1, Stx2) and their variants, Stx2 being more frequently associated with severe cases of HUS. Read More

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October 2018
8 Reads

Stress, stressors, and substance use: Differential risk for hookah use among African American college students.

J Ethn Subst Abuse 2018 Oct 22:1-22. Epub 2018 Oct 22.

a Brown School of Social Work , Washington University in St. Louis , St. Louis , Missouri.

Using differential, multivariable risk models, we assessed the contribution of substance use and stress/traumatic events to hookah use among African American college students (n = 1,402) using data from the Fall 2012 American College Health Association-National College Health Assessment (ACHA-NCHA) II. Lifetime hookah use was 24.8%, with 34. Read More

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October 2018
4 Reads

The Positional Isomeric Effect on the Structural Diversity of Cd(II) Coordination Polymers, Using Flexible Positional Isomeric Ligands Containing Pyridyl, Triazole, and Carboxylate Fragments.

Molecules 2018 Oct 14;23(10). Epub 2018 Oct 14.

Departamento de Química, Facultad de Ciencias Básicas, Universidad de Antofagasta, Casilla 170, Antofagasta 1240000, Chile.

To systematically investigate the influence of the positional isomeric effect on the structures of polymer complexes, we prepared two new polymers containing the two positional isomers ethyl 5-methyl-1-(pyridin-3-yl)-1-1,2,3-triazole-3-carboxylate () and ethyl-5-methyl-1-(pyridin-3-yl)-1-1,2,3-triazole-4-carboxylate (), as well as Cd(II) ions. The structures of the metal⁻organic frameworks were determined by a single crystal XRD analysis. The compound [Cd(L1)₂·4H₂O] (), is a hydrogen bond-induced coordination polymer, whereas the compound [Cd(L2)₄·5H₂O] () is a three-dimensional (3-D) coordination polymer. Read More

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October 2018
1 Read

ATLANTIC-PRIMATES: a dataset of communities and occurrences of primates in the Atlantic Forests of South America.

Authors:
Laurence Culot Lucas Augusto Pereira Ilaria Agostini Marco Antônio Barreto de Almeida Rafael Souza Cruz Alves Izar Aximoff Alex Bager María Celia Baldovino Thiago Ribas Bella Júlio César Bicca-Marques Caryne Braga Carlos Rodrigo Brocardo Ana Kellen Nogueira Campelo Gustavo R Canale Jader da Cruz Cardoso Eduardo Carrano Diogo Cavenague Casanova Camila Righetto Cassano Erika Castro Jorge José Cherem Adriano Garcia Chiarello Braz Antonio Pereira Cosenza Rodrigo Costa-Araújo Nilmara Cristina da Silva Mario S Di Bitetti Aluane Silva Ferreira Priscila Coutinho Ribas Ferreira Marcos de S Fialho Lisieux Franco Fuzessy Guilherme Siniciato Terra Garbino Francini de Oliveira Garcia Cassiano A F R Gatto Carla Cristina Gestich Pablo Rodrigues Gonçalves Nila Rássia Costa Gontijo Maurício Eduardo Graipel Carlos Eduardo Guidorizzi Robson Odeli Espíndola Hack Gabriela Pacheco Hass Renato Richard Hilário André Hirsch Ingrid Holzmann Daniel Henrique Homem Hilton Entringer Júnior Gilberto Sabino-Santos Júnior Maria Cecília Martins Kierulff Christoph Knogge Fernando Lima Elson Fernandes de Lima Cristiana Saddy Martins Adriana Almeida de Lima Alexandre Martins Waldney Pereira Martins Fabiano R de Melo Ricardo Melzew João Marcelo Deliberador Miranda Flávia Miranda Andréia Magro Moraes Tainah Cruz Moreira Maria Santina de Castro Morini Mariana B Nagy-Reis Luciana Oklander Leonardo de Carvalho Oliveira Adriano Pereira Paglia Anderson Pagoto Marcelo Passamani Fernando de Camargo Passos Carlos A Peres Michell Soares de Campos Perine Míriam Plaza Pinto Antonio Rossano Mendes Pontes Marcio Port-Carvalho Bárbara Heliodora Soares do Prado André Luis Regolin Gabriela Cabral Rezende Alessandro Rocha Joedison Dos S Rocha Raisa Reis de Paula Rodarte Lilian Patrícia Sales Edmilson Dos Santos Paloma Marques Santos Christine Steiner São Bernardo Ricardo Sartorello Leonardo La Serra Eleonore Setz Anne Sophie de Almeida E Silva Leonardo Henrique da Silva Pedro Bencke Ermel da Silva Maurício Silveira Rebecca L Smith Sara Machado de Souza Ana Carolina Srbek-Araujo Leonardo Carreira Trevelin Claudio Valladares-Padua Luciana Zago Eduardo Marques Stephen Francis Ferrari Raone Beltrão-Mendes Denison José Henz Francys E da Veiga da Costa Igor Kintopp Ribeiro Lucas Lacerda Toth Quintilham Marcos Dums Pryscilla Moura Lombardi Renata Twardowsky Ramalho Bonikowski Stéfani Gabrieli Age João Pedro Souza-Alves Renata Chagas Rogério Grassetto Teixeira da Cunha Monica Mafra Valença-Montenegro Gabriela Ludwig Leandro Jerusalinsky Gerson Buss Renata Bocorny de Azevedo Roberio Freire Filho Felipe Bufalo Louis Milhe Mayara Mulato Dos Santos Raíssa Sepulvida Daniel da Silva Ferraz Michel Barros Faria Milton Cezar Ribeiro Mauro Galetti

Ecology 2018 Oct 13. Epub 2018 Oct 13.

Departamento de Ecologia, Instituto de Biociências, Universidade Estadual Paulista (UNESP), CP. 199, 13506-900, Rio Claro, São Paulo, Brazil.

Primates play an important role in ecosystem functioning and offer critical insights into human evolution, biology, behavior, and emerging infectious diseases. There are 26 primate species in the Atlantic Forests of South America, 19 of them endemic. We compiled a dataset of 5,472 georeferenced locations of 26 native and 1 introduced primate species, as hybrids in the genera Callithrix and Alouatta. Read More

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October 2018
9 Reads
4.660 Impact Factor

Real-life experience of inhaled iloprost for patients with pulmonary arterial hypertension: Insights from the Spanish REHAP registry.

Int J Cardiol 2019 Jan 5;275:158-164. Epub 2018 Oct 5.

Pulmonary Hypertension Unit, Cardiology Department of Hospital Universitario 12 de Octubre, Avenida de Córdoba s/n, 28041 Madrid, Spain; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Instituto de Salud Carlos III, Avenida de Monforte de Lemos 3-5, 28029 Madrid, Spain. Electronic address:

Introduction: REHAP is a voluntary, observational Spanish registry of patients with pulmonary arterial hypertension. We analyzed the experience (use and effectiveness) with inhaled iloprost (inh-ILO) in real-life conditions during a 3-year period.

Methods: Patients included were those with PAH ≥14 years recruited during 1998-2016 who had received inh-ILO. Read More

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January 2019
5 Reads

On spermatophore-producing aquatic microdrile oligochaetes (Annelida: Clitellata).

Zootaxa 2018 Oct 8;4497(1):41-60. Epub 2018 Oct 8.

Zoology and Animal Cell Biology Dpt., Faculty of Science and Technology, University of the Basque Country UPV/EHU, Apdo. 644, Bilbao 48080, Spain..

The formation of encapsulated spermatophores is exceptional among aquatic oligochaetes, although it seems to have occurred independently in several unrelated taxa. Among the microdriles, some variations appear unique to single species. The recently described lumbriculid Uktena riparia Fend et al. Read More

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October 2018

Abyssocladia vaceleti (Porifera, Cladorhizidae): a new deep-sea carnivorous sponge from Patagonia.

Zootaxa 2018 Aug 31;4466(1):164-173. Epub 2018 Aug 31.

Instituto Español de Oceanografía. Centro Oceanográfico de Gijón, C/ Príncipe de Asturias 70 bis, 33212 Gijón, Asturias, Spain. Departamento de Zoología y Antropología Física. Universidad de Alcalá de Henares. Madrid, Spain.

This study describes a new species of carnivorous sponge (Family Cladorhizidae) collected in Patagonia, SW Atlantic, off Argentinean waters and the North of the Falkland Islands (Malvinas). The species described here, belongs to the genus Abyssocladia and was collected by dredging and trawling during IEO (Spanish Institute of Oceanography) cruises in the South West Atlantic Ocean from 2007 to 2010 under the Atlantis Project. Abyssocladia vaceleti sp. Read More

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Sponge grounds of Artemisina (Porifera, Demospongiae) in the Iberian Peninsula, ecological characterization by ROV techniques.

Zootaxa 2018 Aug 31;4466(1):95-123. Epub 2018 Aug 31.

Instituto Español de Oceanografía. Centro Oceanográfico de Gijón, C/ Príncipe de Asturias 70 bis, 33212 Gijón, Asturias, Spain. Departamento de Zoología y Antropología Física. Universidad de Alcalá de Henares. Madrid, Spain..

Artemisina Vosmaer, 1885 is a poecilosclerid microcionoid sponge genus with 20 valid species, seven of which have been recorded in the Atlantic Ocean.The present study describes Artemisina sponge grounds in Iberia Peninsula. A. Read More

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Senior synonyms for three Neotropical birds described by Louis Vieillot based on Félix de Azara (Passeriformes: Thraupidae, Tyrannidae, Tityridae).

Zootaxa 2018 Jun 11;4433(1):141-150. Epub 2018 Jun 11.

FAUNA Paraguay, Encarnación, Paraguay, www.faunaparaguay.com, and Para La Tierra, Centro IDEAL, Mariscal Estigarribia 321 c/ Tte. Capurro, Pilar, Dpto. Ñeembucú, Paraguay..

The nomenclatural history of three species described by Vieillot based on the descriptions of Félix de Azara is examined. Adherent to the Principle of Priority under the International Code of Zoological Nomenclature, old available names and senior synonyms are identified for the thraupid Uniform Finch Haplospiza plumbea (Vieillot, 1818a); tyrannid Tropical Pewee Contopus sylvestris (Vieillot, 1816); and tityrid White-winged Becard Pachyramphus cyanocephalus (Vieillot, 1816). These names were based respectively on Azara's Number 111 "Pico de punzón obscuro aplomado", Number 168 "Tachurí obscurito mayor" and Number 217 "Batará obscuro y negro". Read More

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June 2018
1 Read

Hepatocellular carcinoma in Latin America: Diagnosis and treatment challenges.

World J Gastroenterol 2018 Oct;24(37):4224-4229

Liver Unit, Hospital Universitario Austral, Facultad de Ciencias Biomédicas, Universidad Austral, Pilar, Buenos Aires B1629HJ, Argentina.

Latin America, a region with a population greater than 600000000 individuals, is well known due to its wide geographic, socio-cultural and economic heterogeneity. Access to health care remains as the main barrier that challenges routine screening, early diagnosis and proper treatment of hepatocellular carcinoma (HCC). Therefore, identification of population at risk, implementation of surveillance programs and access to curative treatments has been poorly obtained in the region. Read More

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October 2018
5 Reads
2.370 Impact Factor

Assessing the capability of in silico mutation protocols for predicting the finite temperature conformation of amino acids.

Phys Chem Chem Phys 2018 Oct;20(40):25901-25909

Biophysics of Tropical Diseases, Max Planck Tandem Group, University of Antioquia, Medellin, Colombia.

Mutation protocols are a key tool in computational biophysics for modelling unknown side chain conformations. In particular, these protocols are used to generate the starting structures for molecular dynamics simulations. The accuracy of the initial side chain and backbone placement is crucial to obtain a stable and quickly converging simulation. Read More

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October 2018
1 Read

High incidence of persistent subtherapeutic levels of the most common AEDs in children with epilepsy receiving polytherapy.

Epilepsy Res 2018 Dec 22;148:107-114. Epub 2018 Sep 22.

INFIBIOC-FFyB-UBA, Junín 954, 1113, CABA, Argentina; Fundación Investigar, C. Beliera 3025 (RN8), B1629WWA Pilar, Buenos Aires, Argentina. Electronic address:

Background: Low levels of AEDs can be secondary drug-drug interactions or related to irregular intake due to poor treatment adherence. This latter behavior is highly suspected in ambulatory pediatric epileptic patients when controls of AEDs are subtherapeutic. However, it cannot be considered for inpatients during long periods of hospitalization. Read More

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December 2018

Aurantoside C Targets and Induces Apoptosis in Triple Negative Breast Cancer Cells.

Mar Drugs 2018 Oct 1;16(10). Epub 2018 Oct 1.

School of Molecular Sciences, The University of Western Australia, Crawley, WA 6009, Australia.

Triple negative breast cancer (TNBC) is a subtype of breast cancers that currently lacks effective targeted therapy. In this study, we found that aurantoside C (C828), isolated from the marine sponge collected from Western Australia, exhibited higher cytotoxic activities in TNBC cells compared with non-TNBC (luminal and normal-like) cells. The cytotoxic effect of C828 was associated to the accumulation of cell at S-phase, resulting in the decline of cyclin D1, cyclin E1, CDK4, and CDK6, and an increase in p21. Read More

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October 2018
1 Read

Feeding a slowly digestible carbohydrate diet during pregnancy of insulin-resistant rats prevents the excess of adipogenesis in their offspring.

J Nutr Biochem 2018 Nov 12;61:183-196. Epub 2018 Jun 12.

Abbott Nutrition R&D, Abbott Laboratories, 18004 Granada, Spain. Electronic address:

An obesogenic environment during pregnancy has been shown to increase the risk of dysregulation on adipogenesis and insulin resistance in the offspring. Being essential for the growing fetus, glucose supply is guaranteed by a number of modifications in the mother's metabolism, and thus, glucose control during pregnancy especially among obese or diabetic women is paramount to prevent adverse consequences in their children. Besides the election of low-glycemic-index carbohydrates, the rate of carbohydrate digestion could be relevant to keep a good glucose control. Read More

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November 2018
7 Reads

Bifidobacterium pseudocatenulatum CECT 7765 supplementation improves inflammatory status in insulin-resistant obese children.

Eur J Nutr 2018 Sep 24. Epub 2018 Sep 24.

Department of Pediatrics, Obstetrics and Gynecology, University of Valencia, Avenida de Blasco Ibañez, no 15, 46010, Valencia, Spain.

Purpose: The relationships between gut microbiota and obesity-related co-morbidities have been increasingly recognized. Low-grade inflammation may be the main factor in the pathogenesis of such disorders. We investigated the effect of the potential probiotic Bifidobacterium pseudocatenulatum CECT 7765 on cardiometabolic risk factors, inflammatory cytokines and gut microbiota composition in obese children with insulin resistance. Read More

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September 2018
21 Reads

Percutaneous Left Atrial Appendage Closure With the Ultraseal Device: Insights From the Initial Multicenter Experience.

JACC Cardiovasc Interv 2018 Oct;11(19):1932-1941

Department of Cardiology, Quebec Heart & Lung Institute, Laval University, Quebec City, Canada. Electronic address:

Objectives: This study sought to evaluate the feasibility, safety, and efficacy of the Ultraseal device for left atrial appendage closure (LAAC) (Cardia, Eagan, Minnesota) in patients with nonvalvular atrial fibrillation at high bleeding risk.

Background: The Ultraseal device is a novel bulb-and-sail designed LAAC device, with an articulating joint enabling conformability to heterogeneous angles and shapes of appendage anatomy.

Methods: This was a multicenter study including consecutive patients undergoing LAAC with the Ultraseal device at 15 Canadian and European sites. Read More

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October 2018

Executive summary of the 2018 KDIGO Hepatitis C in CKD Guideline: welcoming advances in evaluation and management.

Kidney Int 2018 Oct;94(4):663-673

Division of Hepatology, University of Miami, Miami, Florida, USA. Electronic address:

Infection with the hepatitis C virus (HCV) has adverse liver, kidney, and cardiovascular consequences in patients with chronic kidney disease (CKD), including those on dialysis therapy and in those with a kidney transplant. Since the publication of the original Kidney Disease: Improving Global Outcomes (KDIGO) HCV Guideline in 2008, major advances in HCV management, particularly with the advent of direct-acting antiviral therapies, have now made the cure of HCV possible in CKD patients. In addition, diagnostic techniques have evolved to enable the noninvasive diagnosis of liver fibrosis. Read More

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October 2018
5 Reads

Hours of service regulations for professional drivers in continental Latin America.

Sleep Health 2018 Oct 24;4(5):472-475. Epub 2018 Aug 24.

Pulmonary, Critical Care and Sleep Medicine, Yale School of Medicine, New Heaven, CT, USA.

Objectives: To describe the hours of service provisions in continental Latin America.

Design: Information on regulations of service hours was extracted from either the national transportation authorities or ministries of transportation (or the equivalent institution) from each country.

Setting: Seventeen sovereign countries in continental Latin America (Argentina, Bolivia, Brazil, Chile, Colombia, Costa Rica, Ecuador, El Salvador, Guatemala, Honduras, Mexico, Nicaragua, Panama, Paraguay, Peru, Uruguay, Venezuela). Read More

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October 2018
6 Reads

Avocado Seed: A Comparative Study of Antioxidant Content and Capacity in Protecting Oil Models from Oxidation.

Molecules 2018 Sep 21;23(10). Epub 2018 Sep 21.

Chemical Engineering Department, Universitat Politècnica de Catalunya, Av. Diagonal 647, 08028 Barcelona, Spain.

Increasingly, consumers want products containing little or no synthetic compounds. Avocado seeds, which are a residue of the food industry, could be used to obtain extracts with high antioxidant power. In the present study, the most popular radical scavenging methods are presented, establishing a comparison between them, besides working with two different extractions: pure methanol and ethanol⁻water (50:50 ). Read More

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September 2018

Improving Immunohistochemistry Capability for Pediatric Cancer Care in the Central American and Caribbean Region: A Report From the AHOPCA Pathology Working Group.

J Glob Oncol 2018 Sep(4):1-9

Teresa Santiago, Caleb Hayes, Carlos Rodriguez-Galindo, and Monika L. Metzger, St Jude Children's Research Hospital, Memphis, TN; Ana Concepción Polanco, Hospital Nacional de Niños Benjamín Bloom, San Salvador, El Salvador; Lisa Miranda, Hospital Nacional de Niños "Dr. Carlos Sáenz Herrera," San José, Costa Rica; Argelia Aybar, MediPath, Santiago City; Belkis Gomero, Hospital Infantil Dr. Robert Reid Cabral, Santo Domingo, Dominican Republic; Elizabeth Orellana, Francisco Marroquín Medical School, Guatemala City, Guatemala; Fabienne Anglade, Laboratory Regional Stephen at Pilar Robert, Mirebelais, Haiti; Mázlova Luxely Toledo González, Hospital Escuela-Universitario, Tegucigalpa, Honduras; Eduviges Ruiz, Hospital Infantil Manuel de Jesus Rivera "La Mascota," Managua, Nicaragua; Moisés Espino-Durán, Hospital del Niño Dr. José Renán Esquivel, Panama City, Panama.

Accessibility to immunohistochemistry (IHC) is invaluable to proper diagnosis and treatment of pediatric patients with malignant neoplasms. Whereas IHC is widely available in anatomic pathology laboratories in high-income countries, access to it in anatomic pathology laboratories of low- and middle-income countries remains a struggle, with many limitations. To advance the quality of the pathology service offered to children with cancer in areas with limited resources, a 5-day pathology training workshop was offered to pathologists and histotechnologists from various countries of the Central American and Caribbean region. Read More

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September 2018
5 Reads

Oropharyngeal Trichomonosis Due to Trichomonas Gypaetinii in a Cinereous Vulture ( Aegypius Monachus) Fledgling in Spain.

J Wildl Dis 2018 Sep 20. Epub 2018 Sep 20.

6 Department of Animal Health, Faculty of Veterinary Sciences, Complutense University of Madrid, Av. Puerta de Hierro, s/n, Madrid 28040, Spain.

A juvenile Cinereous Vulture ( Aegypius monachus) fledgling was found disorientated on the roof of a building in Madrid City, Spain, in October 2016. A veterinary examination revealed multiple plaques distributed throughout the oropharyngeal cavity. Lesions were located under the tongue and at the choanal slit, hard palate, and esophagus opening and ranged from 2 to 7 mm, coalescing in areas up to 2 cm, with a yellowish color of the surface. Read More

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September 2018
2 Reads

Analysis of Contact Traces of Cannabis by In-Tube Solid-Phase Microextraction Coupled to Nanoliquid Chromatography.

Molecules 2018 Sep 15;23(9). Epub 2018 Sep 15.

MINTOTA Research Group, Department of Analytical Chemistry, Faculty of Chemistry, University of Valencia, Dr. Moliner 50, 46100 Burjassot, Valencia, Spain.

Because of its inherent qualities, in-tube solid-phase microextraction (IT-SPME) coupled on-line to nanoliquid chromatography (nanoLC) can be a very powerful tool to address the new challenges of analytical laboratories such as the analysis of traces of complex samples. This is the case of the detection of contact traces of drugs, especially cannabis. The main difficulties encountered in the analysis of traces of cannabis plants on surfaces are the low amount of sample available (typically < 1 mg), the complexity of the matrix, and the low percentages of cannabinoic compounds in the samples. Read More

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September 2018

Fabry disease. A potential pitfall A family with a novel intronic mutation.

Mol Genet Metab Rep 2018 Dec 8;17:16-17. Epub 2018 Sep 8.

Co-Director Médico Fresenius Pilar, Buenos Aires, Argentina.

Fabry disease is a genetic disorder characterized by the accumulation of globotriaosylceramide in cell lysosomes resulting from an X-linked deficiency of α-galactosidase A activity. It presents with multiorgan manifestations, including progressive renal disease, cardiomyopathy and premature demise. Recently, its prevalence has been reported to be higher in hemodialysis (HD) patients than in the general population. Read More

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December 2018
1 Read

In vitro antiplasmodial activity and identification, using tandem LC-MS, of alkaloids from Aspidosperma excelsum, a plant used to treat malaria in Amazonia.

J Ethnopharmacol 2019 Jan 7;228:99-109. Epub 2018 Sep 7.

Graduate Program in Pharmaceutical Sciences, Federal University of Pará, R. Augusto Corrêa, 01, Guamá, CEP 66075-110 Belém, Pará, Brazil; Faculty of Pharmacy, Institute of Health Sciences, Federal University of Pará, R. Augusto Corrêa, 01, Guamá, CEP 66075-110 Belém, Pará, Brazil. Electronic address:

Ethnopharmacological Relevance: Aspidosperma excelsum Benth. (Apocynaceae), a native tree in the Brazilian Amazonia, is traditionally used to treat various diseases, including malaria.

Aim Of Study: To investigate the chemical constitution, antiplasmodial activity and cytotoxicity of samples obtained from A. Read More

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January 2019

Temporal transitions in COPD severity stages within the GOLD 2017 classification system.

Respir Med 2018 09 3;142:81-85. Epub 2018 Aug 3.

Pulmonary Department, Hospital Universitario Nuestra Señora de La Candelaria, Universidad de La Laguna, Tenerife, Spain. Electronic address:

Background: The stability of the new GOLD 2017 COPD staging is unknown, as well as the frequency of individual transitions in COPD stages beyond one year.

Methods: All COPD participants in the CHAIN cohort were re-analysed according to GOLD 2017 up to five years of follow-up. Their individual changes within COPD stages were aggregated into cohort-wide Markov chains; group stability was evaluated using joinpoint regression. Read More

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September 2018
13 Reads

Study About the Efficacy of an Aerosol Plastic Dressing in Wound Prevention After Compressive Adhesive Dressing Application in Plastic Surgery Procedures.

Plast Surg Nurs 2018 Jul/Sep;38(3):101-104

Enrique Salmerón-González, MD, is a plastic surgeon, Department of Plastic Surgery and Burns, University and Polytechnic Hospital La Fe, Valencia, Spain. Elena García-Vilariño, MD, is a plastic surgeon, Department of Plastic Surgery and Burns, University and Polytechnic Hospital La Fe, Valencia, Spain. Pilar Vilariño-López, MD, is a general nurse, El Ventorrillo Medical Center, A Coruña, Spain. Cristina García-Pons, MD, is a plastic surgical nurse, Department of Plastic Surgery and Burns, University and Polytechnic Hospital La Fe, Valencia, Spain. Cristina Escalante-Ibáñez, MD, is a plastic surgical nurse, Servicio de Cirugía Plástica y Quemados, Hospital Universitario y Politécnico La Fe, Valencia, Spain. Alfonso A. Valverde-Navarro, MD, is Head of the Department of Human Anatomy and Embriology, University of Valencia, Valencia, Spain.

The use of compressive adhesive bandages is widely extended in the field of plastic, aesthetic, and reconstructive surgery, and the apparition of skin damage after its removal is a relatively frequent complication. The aim of this study was to evaluate the capacity of an aerosol plastic dressing for protecting the skin from the apparition of damage caused by adhesive dressings. A prospective, randomized, simple-blind study was performed, evaluating skin damage incidence after removal of adhesive compressive bandages in 80 subjects. Read More

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August 2018
2 Reads

Diffuse infantile hepatic haemangioma-how to manage an incidental but potentially lethal finding.

Oxf Med Case Reports 2018 Aug 21;2018(8):omy054. Epub 2018 Aug 21.

Paediatrics Department, Hospital Dr. Nélio Mendonça, Funchal, Portugal.

Infantile hepatic haemangioma (IHH) is a rare vascular tumour that is potentially lethal due to its associated complications, including heart failure, hepatic failure, hypothyroidism and abdominal compartment syndrome. The authors report a case of an asymptomatic diffuse IHH in a newborn male, which was presented as an incidental finding at the time that the patient was diagnosed with pyloric stenosis. The patient was treated with increasing doses of propranolol that were well tolerated. Read More

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August 2018
2 Reads

Hospitalisation Cost of Patients with Diabetic Foot Ulcers in Valencia (Spain) in the Period 2009⁻2013: A Retrospective Descriptive Analysis.

Int J Environ Res Public Health 2018 08 24;15(9). Epub 2018 Aug 24.

Department of Nursing and Podiatry, University of Malaga, IBIMA, 29071 Malaga, Spain.

Ulcers are the main cause of hospitalisation and clinical complications in patients with diabetes. We analyse the length and cost of hospital stay of patients with diabetic foot ulcers, taking into consideration that hospitalisation and, if necessary, amputation represent the greatest area of expense to the healthcare system for such patients. This analysis focuses on the treatment provided to these patients in public hospitals in the region of Valencia (Spain), registered in the Spanish Minimum Basic Data Set, during the period 2009⁻2013. Read More

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Selection of potential non-Sacharomyces probiotic yeasts from food origin by a step-by-step approach.

Food Res Int 2018 Oct 5;112:143-151. Epub 2018 Jun 5.

Food Science and Technology Department, Castilla-La Mancha University, Av. Camilo José Cela S/N, Edificio Marie Curie, Ciudad Real 13071, Spain. Electronic address:

Due to healthcare is increasing in nowadays, the use of the commercial probiotics is in progress and each day they are more demanded. The challenge of this study is to identify yeast species for using as probiotic organisms. Thus, the research applied a step-by-step approach, to study the probiotic potential of non-Saccharomyces yeast strains. Read More

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October 2018

A Method for Isolation of the Virome from Plasma Samples.

Methods Mol Biol 2018 ;1838:165-171

Department of Genetics, Institute for Integrative Systems Biology, Universitat de València, Paterna, Spain.

Virome studies are of special interest nowadays. Understanding viral communities in different body compartments will help guide future personalized treatments and to discern between homeostasis and disease. High-throughput sequencing technologies allow us to detect all the nucleic acids present in a sample, including viral ones, by random sequencing. Read More

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January 2018
5 Reads

Spectroscopy of a rotating hydrogen molecule in carbon nanotubes.

Phys Chem Chem Phys 2018 Aug 17. Epub 2018 Aug 17.

Laboratoire Modélisation et Simulation Multi Echelle, MSME UMR 8208 CNRS, Université Paris-Est, 5 bd Descartes, 77454 Marne-la-Vallée, France.

A first-principles study of the spectroscopy of a single hydrogen molecule rotating inside and outside of carbon nanotubes is presented. Density functional theory (DFT)-based symmetry-adapted perturbation theory (SAPT) is applied to analyze the influence of the rotation in the dispersionless and dispersion energy contributions to the adsorbate-nanotube interaction. A potential model for the H2-nanotube interaction is proposed and applied to derive the molecular energy levels of the rotating hydrogen molecule. Read More

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