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J Orthop Surg (Hong Kong) 2021 May-Aug;29(2):23094990211022042

Department of Orthopaedic Surgery, 38014Chang Gung Memorial Hospital at Linkou, Guishan District, Taoyuan City.

Purpose: The purpose of this study is to evaluate the outcome and prognosis of complete synovectomy performed under arthroscopic surgery in the treatment of diffuse pigmented villonodular synovitis (DPVNS) of the knee.

Methods: We retrospectively reviewed 7 cases (6 female and 1 male) diagnosed with diffuse pigmented villonodular synovitis (DPVNS) of knee from 2013 to 2017. All of these cases were treated with knee arthroscopy-assisted complete synovectomy. Read More

Cureus 2021 Apr 17;13(4):e14529. Epub 2021 Apr 17.

Orthopaedic Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, USA.

A 34-year-old woman presented with paroxysmal, insidious shoulder pain with effusion. MRI demonstrated a permeative, intermediate-signal lesion on T1 and T2 sequences involving the glenohumeral joint and biceps tendon sheath. The patient was treated with arthroscopic synovectomy, debridement, and subpectoral biceps tenodesis, with histopathology demonstrating pigmented villonodular synovitis (PVNS). Read More

Am J Sports Med 2021 May 17:3635465211013006. Epub 2021 May 17.

American Hip Institute Research Foundation, Chicago, Illinois, USA.

Background: There is a paucity of midterm outcome data on hip revision arthroscopic surgery.

Purpose: (1) To report minimum 5-year patient-reported outcome measurement scores (PROMSs) in patients who underwent revision hip arthroscopy, (2) to compare minimum 5-year PROMSs with a propensity-matched control group that underwent primary hip arthroscopy, and (3) to compare the rate of achieving the minimal clinically important difference (MCID) at minimum 5-year follow-up between the revision group and the propensity-matched control primary group.

Study Design: Cohort study; Level of evidence, 3. Read More

Autoimmun Rev 2021 Jul 7;20(7):102848. Epub 2021 May 7.

Rheumatology Unit, Bnai-Zion Medical Center and Technion, Haifa, Israel; Ruth & Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel. Electronic address:

Purpose: To reassess the diagnostic approach to a patient with a monoarticular disease in light of the up-to-date medical literature and to examine the practical utility of traditional and newer imaging tools in the setting of monoarthritis.

Results: The monoarticular disease can represent a medical emergency on the one hand and be a diagnostic conundrum on the other. The management rules of patients with monoarthritis have been established long ago, but various pitfalls still lead physicians off the right diagnosis at times. Read More

Int J Surg Case Rep 2021 May 27;82:105920. Epub 2021 Apr 27.

Michael Garron Hospital, Toronto, ON, Canada; University of Toronto, Toronto, ON, Canada.

Introduction And Importance: Tophacious gout presenting at the anterior cruciate ligament (ACL) is extremely rare and difficult to differentiate from other intraarticular pathology. This is mainly due to conventional diagnostic tools, such as MRI, producing ambiguous results versus pigmented villonodular synovitis (PVNS) and ganglion cysts.

Case Presentation: Here we report an individual in their late-20s with a gouty tophus located at the origin of the ACL in the knee. Read More

Cureus 2021 Mar 18;13(3):e13962. Epub 2021 Mar 18.

Orthopedic Surgery, King Abdullah Medical City, Mecca, SAU.

Osteoarticular tuberculosis (TB) of the ankle joint is rare, and there is a delay in diagnosis in most cases. All patients with the disease complained of swelling and pain in the affected ankle. Ankle TB is a disorder that can be simply misdiagnosed. Read More

Pediatr Radiol 2021 Apr 9. Epub 2021 Apr 9.

Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, 225 E. Chicago Ave., Chicago, IL, 60611, USA.

Background: The etiologies of pediatric solid intra-articular soft-tissue masses are not well described and can present diagnostic dilemmas.

Objective: Our hypothesis was that these entities have a limited differential diagnosis and are mostly benign.

Materials And Methods: We reviewed knee magnetic resonance imaging (MRI) scans performed at our tertiary care institution between 2001 and 2019 (n=3,915). Read More

Cranio 2021 Apr 9:1-4. Epub 2021 Apr 9.

Pathology Department, Haydarpa#x15F;a Numune Training and Research Hospital, Istanbul, Turkey.

: Pigmented villonodular synovitis (PVNS) is an infrequent benign tumor-like proliferative lesion developing from the synovial membranes of the joint, tendon sheath, and bursa.: A 44-year-old woman with numbness on the right side of her face, severe headaches, and swelling in temporomandibular region is presented. On head and neck magnetic resonance imaging, an encapsulated mass approximately 2 cm was detected. Read More

JBJS Case Connect 2021 04 2;11(2). Epub 2021 Apr 2.

Orthopaedic Surgery Department, Groupe Hospitalier Paris Saint Joseph, Paris, France.

Cases: We used the modified Stoppa approach in a 17-year-old man with a retained bullet in his acetabular fossa. The acetabular hole was used to irrigate the hip joint. We also used this approach in a 29-year-old woman with right hip pain and limping to remove an isolated tenosynovial giant cell tumor ("localized pigmented villonodular synovitis") in the acetabular fossa expanding through the acetabulum. Read More

Bone Joint J 2021 Apr;103-B(4):788-794

Department of Orthopaedic Surgery, Nuffield Orthopaedic Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.

Aims: Tenosynovial giant cell tumour (TGCT) is one of the most common soft-tissue tumours of the foot and ankle and can behave in a locally aggressive manner. Tumour control can be difficult, despite the various methods of treatment available. Since treatment guidelines are lacking, the aim of this study was to review the multidisciplinary management by presenting the largest series of TGCT of the foot and ankle to date from two specialized sarcoma centres. Read More

Clin Orthop Relat Res 2021 05;479(5):1002-1013

T. Yamamoto, S. D. Steppacher, M. Tannast, Department of Orthopaedic Surgery, Inselspital Bern, University of Bern, Bern, Switzerland.

Background: Several classification systems have been used to describe early lesions of hip cartilage and the acetabular labrum in young adults with hip pain. Some of them were introduced before the concept of femoroacetabular impingement was proposed. Others were developed for other joints (such as the patellofemoral joint). Read More

Int J Clin Exp Pathol 2021 1;14(3):383-388. Epub 2021 Mar 1.

Department of Orthopaedic Surgery, The Affiliated Southeast Hospital of Xiamen University, Orthopaedic Center of People's Liberation Army Zhangzhou 363000, Fujian Province, China.

Background: Pigmented villonodular synovitis (PVNS) is a rare benign proliferative disorder of the synovium. It rarely occurs in adolescents, particularly in immature patients with bilateral manifestation.

Case Presentation: We present a case of atypical and bilateral PVNS of wrist in a 14-year-old boy. Read More

Medicine (Baltimore) 2021 Mar;100(12):e23794

Department of Orthopedics, Kaohsiung Veterans General Hospital, Kaohsiung.

Abstract: Diffuse pigmented villonodular synovitis (PVNS) of knee is a rare benign disease that has a destructive clinical course. Synovectomy and adjuvant radiotherapy (RT) have been reported as treatment options but literatures reporting functional outcomes were sparse. This study aimed to evaluate the long-term functional outcomes and disease control among treatment modalities through the 22 years of experience. Read More

J Foot Ankle Surg 2021 Feb 9. Epub 2021 Feb 9.

Department of Orthopaedics and Traumatology, North District Hospital, Sheung Shui, Hong Kong SAR, China. Electronic address:

Pigmented villonodular synovitis (PVNS) of the tendon sheath (tenosynovial giant cell tumor) is a rare disorder that is often misdiagnosed because of slow growth and an atypical presentation. Open surgical excision is the treatment of choice, although recurrence is a common complication. In this report, a case of PVNS of the flexor hallucis longus tendon in the ankle and hindfoot is described. Read More

J Surg Case Rep 2021 Mar 8;2021(3):rjab019. Epub 2021 Mar 8.

Traumatology Sports Center (CETE), (DOT-UNIFESP/EPM), Orthopedics and Traumatology Department of the Escola Paulista de Medicina, Federal University of São Paulo São Paulo, SP, Brazil.

Pigmented villonodular synovitis (PVNS) is a non-neoplastic proliferative process that involves synovial tissue in the joints, tendon sheaths and bursae. It usually occurs in young adults, aged 20-50 years, is characteristically monoarticular and of slow progression. Clinical symptoms are nonspecific, and joint stiffness and pain are common in long-term cases. Read More

J Orthop Case Rep 2020 Nov;10(8):6-10

Department of Orthopaedic Surgery and Rehabilitation, Loyola University Medical Center, Maywood, USA.

Introduction: Histiocytoses are rare disorders and most orthopedic surgeons are unfamiliar with this diagnosis. We report a case of synovial non-Langerhans cell histiocytosis (LCH) located in the shoulder, which has not been reported in the literature previously.

Case Report: A 24-year-old female patient presented to our clinic with shoulder pain and decreased range of motion. Read More

Radiol Case Rep 2021 Apr 13;16(4):950-955. Epub 2021 Feb 13.

Orthopaedic Oncology Department, Miami Cancer Institute, 8900 N Kendall Dr., Miami, FL 33176, USA.

Tenosynovial giant cell tumors are extremely rare tumors with highly nonspecific symptoms. This benign but aggressive disease has a slow course of progression; however, it can ultimately lead to irreversible damage to a joint. Here we describe a case of a 45-year-old female with a diagnosis of tenosynovial giant cell tumors of the distal tibiofibular joint, the second case described in the literature for such location. Read More

World J Clin Cases 2021 Feb;9(6):1379-1385

School of International Education, Weifang Medical University, Weifang 261053, Shandong Province, China.

Background: Pigmented villonodular synovitis (PVNS) is an uncommon disease that usually occurs in large joints, and involvement of the subtalar joint is rare. The lack of comprehensive knowledge of subtalar joint PVNS could lead to misdiagnosis.

Case Summary: We present a 64-year-old woman who, at her first visit, complained of discomfort in the right ankle when she walked. Read More

Knee Surg Relat Res 2021 Feb 25;33(1). Epub 2021 Feb 25.

Orthopaedics Department, Whipps Cross University Hospital, Barts Health NHS Trust, Whipps Cross Road, Leytonstone, London, E11 1NR, UK.

Background: To determine the functional outcomes, complications and revision rates following total knee arthroplasty (TKA) in patients with pigmented villonodular synovitis (PVNS).

Materials And Methods: We conducted a systematic review of the literature. Five studies with a total of 552 TKAs were included for analysis. Read More

Clin Nucl Med 2021 May;46(5):405-408

From the Department of Nuclear Medicine, The Second Hospital of Jilin University, Changchun, Jilin Province, China.

Abstract: Pigmented villonodular synovitis (PVNS) is a rare proliferative synovial benign disorder, which is characterized by villonodular hyperplasia of joints, tendon sheath, and synovium; invasion of adjacent tissue; and sometimes visible hemosiderin deposition. Studies regarding bone scan findings of PVNS were relatively limited. Here, we report our findings on 99mTc-MDP 3-phase bone scan with SPECT/CT images on delayed phase in 3 patients with joint PVNS. Read More

J Mol Histol 2021 Apr 18;52(2):397-406. Epub 2021 Feb 18.

Department of Orthopedics, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, 200233, China.

Pigmented villonodular synovitis (PVNS) is a rare hyperplasia disease of the synovium with a predilection for the knee in either a localized (LPVNS) or a diffuse form (DPVNS). But the exact cause is not clear. The aim of this study was to explore the relationship between the expression of cellular inhibitor of apoptosis 2 (cIAP2) and proliferation, apoptosis, invasive growth and postoperative recurrence in PVNS. Read More

Clin Neurol Neurosurg 2021 Mar 12;202:106489. Epub 2021 Jan 12.

Department of Neurosurgery, Tulane Medical Center, New Orleans, LA, USA; Department of Neurosurgery, Ochsner Clinic Foundation, New Orleans, LA, USA. Electronic address:

Background And Objective: Pigmented villonodular synovitis (PVNS) is a lesion of uncertain etiology that involves the synovial membranes of joints or tendon sheaths, representing a diffuse and non-encapsulated form of the more common giant cell tumors of the synovium (GCTTS). PVNS was reclassified to denote a diffuse form of synovial giant cell tumor (TSGCT), while 'giant cell tumor of the tendon sheath (GCTTS)' was used for localized lesions. These pathologies rarely affect the axial skeleton. Read More

Jt Dis Relat Surg 2021 6;32(1):258-261. Epub 2021 Jan 6.

Department of Orthopedic Surgery, Nanoori Hospital Gangnam, 63-8 Nonhyun-Dong, Gangnam-gu, Seoul 06048, Republic of Korea.

Pigmented villonodular synovitis (PVNS) occurs most frequently in the knee and hand joints and is extremely rare in the shoulder joints. A 27-year-old women was admitted to our outpatient clinic with an abrupt-onset pain and limited range of motion of the left shoulder. On arthroscopic examination, localized PVNS surrounding the reactive synovitis in the posterior aspect of the subscapularis within the shoulder joint cavity. Read More

Cureus 2020 Dec 5;12(12):e11929. Epub 2020 Dec 5.

Orthopaedic Department, Papageorgiou General Hospital of Thessaloniki, Thessaloniki, GRC.

Pigmented villonodular synovitis (PVNS) is a relatively rare, benign lesion characterized by exuberant proliferation of the synovial tissue that most commonly affects the knee and hip joint. Magnetic resonance imaging (MRI) is the imaging modality of choice for the diagnosis of PVNS. The disease is confirmed histologically by examination of the synovial tissue removed. Read More

Acta Orthop Belg 2020 Jun;86(2):342-346

The authors present a case of monoarticular localized pigmented villonodular synovitis (PVNS) in a 7-year old girl. PVNS is a rare benign disease of the synovial tissue. It is especially rare in ankles of children, with only 15 cases reported in literature. Read More

BMC Musculoskelet Disord 2021 Jan 7;22(1):41. Epub 2021 Jan 7.

Department of Orthopaedic Surgery, Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, 109 Xueyuan Xi Road, 325027, Wenzhou, Zhejiang, China.

Background: Pigmented villonodular synovitis (PVNS) is a rare, benign, proliferative neoplastic process that commonly affects synovial-lined anatomic spaces. The diffuse type (DPVNS) is characterized by invasion of the entire joint synovium, while the localized type (LPVNS) is characterized by a relatively normal synovial appearance. This report describes a unique case of massive intraarticular LPVNS with an extraarticular extension through the lateral patellar retinaculum. Read More

Skeletal Radiol 2021 Jan 7. Epub 2021 Jan 7.

University of Missouri, Columbia, MO, USA.

Objective: To determine the frequency with which MRI of tenosynovial giant cell tumor demonstrates hemosiderin, visible intralesional fat signal, and proximity to synovial tissue.

Material And Methods: This is a retrospective study of 31 cases of tenosynovial giant cell tumors which had concomitant MRI. Images were examined for lesion size, morphology, origin, bone erosions, MRI signal characteristics, contrast enhancement, and blooming artifact, comparing prospective and retrospective reports. Read More

Clin Case Rep 2020 Dec 12;8(12):2346-2349. Epub 2020 Jul 12.

Department of Neurosurgery Trauma and Burns Center Ben Arous Tunisia.

Lumbar pigmented villonodular synovitis is rarely localized on the lumbar spine. Awareness of pigmented villonodular synovitis is important despite its rarity because it may mimic several other lesions of this location. Read More

Beijing Da Xue Xue Bao Yi Xue Ban 2020 Dec;52(6):1135-1139

We reported a case of rheumatoid arthritis (RA) combined with pigmented villonodular synovitis (PVNS) from Peking University People's Hospital. The clinical data were introduced and the related literature was reviewed. The clinical features, treatment and prognosis of the disease were summarized to improve clinicians' understanding of this rare disease and avoid misdiagnosis and delayed diagnosis. Read More

SICOT J 2020 11;6:48. Epub 2020 Dec 11.

Senior Resident, Department of Pathology, All India Institute of Medical Sciences, 248201 Rishikesh, India.

Introduction: Chronic synovitis involving a single large joint remains a diagnostic dilemma. We present 61 cases of chronic synovitis of the knee, followed prospectively for 2 years. The study focuses on the diagnosis, management, and histopathological correlation. Read More