Search Our Scientific Publications & Authors

Folia Med Cracov 2018 ;58(4):93-104

Human Anatomy Department, Medical University of Lublin; Radiology Department, St Johns' Cancer Center; Lublin, Poland.

Pigmented villonodular synovitis (PVNS) is a benign disease that rarely undergoes malignant transformation. There are two types of disease: localized (nodular tenosynovitis) and di used (pigmented villonodular synovitis/tenosynovitis) with intra- or extra-articular locations. The second one is limited to synovium of the burse (PVNB) or tendon sheath (PVNTS). Read More

Reumatol Clin 2019 Jan 25. Epub 2019 Jan 25.

Servicio de Reumatología, Hospital General Universitario de Ciudad Real, Ciudad Real, España.

Our hospital is the nuclear medicine referral hospital for radioisotopic synoviorthesis for all of Castilla-La Mancha.

Objective: To describe the experience in the performance of radioisotopic synoviorthesis for arthritis refractory to other treatments in our hospital.

Methodology: Observational, descriptive and cross-sectional study protocolised through the review of the database of radioisotopic synoviorthesis performed between 2007 and 2017. Read More

J Hip Preserv Surg 2018 Dec 31;5(4):443-447. Epub 2018 Oct 31.

Minimal Invasive Orthopedics Unit, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel.

This report presents a case of a 37-year-old female with a history of hip pain. Magnetic resonance arthrography revealed loose bodies within the joint and synovial hypertrophy indicative of synovial chondromatosis (SC). Hip arthroscopy revealed free chondral bodies and focal villonodular synovial proliferation. Read More

Case Rep Orthop 2018 6;2018:7698052. Epub 2018 Dec 6.

Cliniques Universitaires Saint-Luc, Service d'Orthopédie et de Traumatologie de l'Appareil Locomoteur, Avenue Hippocrate 10, B-1200 Brussels, Belgium.

Noonan-like/multiple giant cell lesion (NS/MGCL) is a rare condition overlapping with Noonan syndrome. Once thought to be a specific and separate entity, it is now suggested to be a variant of the Noonan syndrome spectrum. We report the case of an 8-year-old boy with a typical clinical picture of Noonan syndrome with a de novo germline mutation of PTPN11 (c. Read More

Kathmandu Univ Med J (KUMJ) 2018 Jan.-Mar;16(61):28-34

Department of Orthopedics, B and C Teaching Hospital, Birtamod, Jhapa.

Background Ankle and foot pain is a common clinical problem, that may be due to a variety of soft tissue and osseus abnormalities. Magnetic resonance imaging plays vital role for diagnosing internal derangement of the ankle joint, assessing soft tissue structures around the ankle such as tendons, ligaments, nerves and osseus structures. Method Retrospective magnetic resonance imaging evaluation of the ankle and foot was done in 100 patients using 0. Read More

J Clin Rheumatol 2019 Jan 4. Epub 2019 Jan 4.

From the Departments of Diagnostic Imaging, and.

J Foot Ankle Surg 2019 Jan 3. Epub 2019 Jan 3.

Director, Podiatric Surgical Residency, Beaumont Hospital Wayne, Wayne, MI.

Chronic gout is defined as accumulation of monosodium urate crystals in joints, cartilage, tendons, bursae, bone, and soft tissue. The foot is the most common location for acute gout flares, with the first metatarsophalangeal joint being the most frequent site of tophus formation. However, few studies have reported gouty tophus formation in the subtalar joint. Read More

J Clin Rheumatol 2018 Dec 28. Epub 2018 Dec 28.

Rheumatology Unit, San Giovanni di Dio Hospital, Florence, Italy.

Arthrosc Tech 2018 Dec 5;7(12):e1257-e1261. Epub 2018 Nov 5.

Department of Orthopaedics and Traumatology, Tuen Mun Hospital, Tuen Mun, China.

Synovitis of the ulnar bursa is associated with tenosynovitis of the flexor tendons. Reported causes include suppurative or tuberculous infection, rheumatoid arthritis, and pigmented villonodular synovitis. Open synovectomy requires extensive soft-tissue dissection and may result in extensive scarring. Read More

J Orthop Case Rep 2018 May-Jun;8(3):14-17

Department of Orthopaedic Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Introduction: Diffuse-type tenosynovial giant cell tumor (D-TGCT), or pigmented villonodular synovitis, is a benign, but aggressive lesion, primarily involving large joints. The spine is rarely affected, with the involvement of the thoracic spine being particularly rare. Massive bone involvement associated with facet joints is a characteristic of spinal D-TGCT. Read More

Arthroplast Today 2018 Dec 13;4(4):426-430. Epub 2018 Aug 13.

Department of Orthopaedic Surgery, University of Connecticut, Farmington, CT, USA.

Pigmented villonodular synovitis (PVNS) is a benign proliferative joint disease, which is a rare finding after total knee arthroplasty (TKA). There is currently no link between PVNS and TKA, and it has been described infrequently in the literature. Its presentation has varied along with the time that it presents postoperatively. Read More

J Orthop Sci 2018 Dec 13. Epub 2018 Dec 13.

Department of Orthopaedic Surgery, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.

Background: Joint-preserving procedures should be considered as much as possible for hip disorders in pediatric and young patients. However, in patients with extensive osteonecrosis (ON) of the femoral head combined with severe collapse and advanced secondary osteoarthritis (OA), the optimal procedure has not been elucidated. This retrospective study aimed to investigate the postoperative outcomes of 11 patients who underwent transtrochanteric rotational osteotomy (TRO) alone or with a combination treatment for various hip disorders in young patients and to evaluate the usefulness of TRO. Read More

Arch Orthop Trauma Surg 2018 Dec 11. Epub 2018 Dec 11.

Department of Nuclear Medicine, University Hospital, LMU Munich, Munich, Germany.

Introduction: Tenosynovial giant-cell tumor also known as pigmented villonodular synovitis (PVS) is a benign but aggressive synovial proliferative disease most often affecting the knee joint. The mainstay of therapy is surgical resection. Due to a high rate of local recurrence, radiosynoviorthesis (RSO) is used as an adjuvant method in many cases. Read More

Auris Nasus Larynx 2018 Nov 26. Epub 2018 Nov 26.

Department of Head and Neck Surgry, Tokyo Medical and Dental University, Japan.

Objective: Pigmented villonodular synovitis occurring in the region of the temporomandibular joint is a rare disease, requiring a review of the treatment method, follow-up period.

Method: Refer to the past literature, along with a retrospective search.

Results: An excision, including the skull base bone, was performed in all cases; however, recurrence was found in one case on which fractional excision was performed. Read More

Knee 2018 12 25;25(6):1322-1323. Epub 2018 Oct 25.

IRCCS Istituto Ortopedico Galeazzi, Via Riccardo Galeazzi, 4, 20161 Milan, Italy.

Orthop J Sports Med 2018 Nov 12;6(11):2325967118807176. Epub 2018 Nov 12.

Department of Orthopaedic Surgery, Stanford University School of Medicine, Stanford, California, USA.

Background: The preoperative diagnosis of hip microinstability is challenging. Although physical examination maneuvers and magnetic resonance imaging findings associated with microinstability have been described, there are limited reports of radiographic features. In patients with microinstability, we observed a high incidence of a steep drop-off on the lateral edge of the femoral head, which we have named the "cliff sign. Read More

J Orthop Surg Res 2018 Nov 20;13(1):294. Epub 2018 Nov 20.

Department of Orthopaedic Surgery, General Hospital of People's Liberation Army, No.28 Fuxing Road, Haidian District, Beijing, 100853, China.

Background: Pigmented villonodular synovitis (PVNS) is a relatively rare, locally aggressive, and potentially recurrent synovial disease of large joints. The purpose of this study was to investigate (1) the disease recurrence rate and (2) the treatment outcomes including Harris hip scores, complications, and revision following cementless total hip arthroplasty (THA) with ceramic-on-ceramic (CoC) articulation in patients with PVNS.

Methods: Twenty-two patients (14 females and 8 males) with histologically confirmed PVNS underwent cementless THA using CoC bearings between 2000 and 2013. Read More

J Ultrason 2018 ;18(74):212-223

Leeds Teaching Hospitals and Leeds University, Leeds, UK.

There are numerous abnormalities that present with similar signs and symptoms to arthritis. In this article some of these conditions that can masquerade as arthritis are discussed. Synovial osteochondromatosis is an uncommon benign disorder marked by the metaplastic proliferation of multiple cartilaginous nodules in the synovial membrane of the joints, bursae, or tendon sheaths. Read More

J Knee Surg 2018 Nov 16. Epub 2018 Nov 16.

Department of Orthopedic Surgery, Wake Forest University School of Medicine, Winston-Salem, North Carolina.

Intra-articular (IA) and peri-articular (PA) tumors of the knee are frequently encountered by orthopaedic surgeons. Nonetheless, due to the possibility of great morbidity and potential mortality, it is important to recognize and differentiate between benign and malignant lesions in a timely manner. Therefore, the purpose of this article is to provide a concise, practical, and updated review of commonly encountered IA and PA tumors including intratendinous gout, synovial chondromatosis, schwannoma, pigmented villonodular synovitis, and synovial sarcoma, and a detailed description of differentiating features to include various imaging modalities. Read More

J Long Term Eff Med Implants 2018 ;28(2):87-99

Orthopaedic Oncology, Washington Cancer Institute, Georgetown University School of Medicine, Washington, DC.

We summarize the results and clinical usefulness of cytogenetic analysis that is routinely performed for musculoskeletal tumors. We performed cytogenetic analysis and traditional histologic evaluation on 101 (51 malignant/ 50 benign) consecutive tumors that were surgically excised. The successful culture rate for cytogenetic analysis was 86% (87/101). Read More

J Arthroplasty 2019 Jan 6;34(1):36-39. Epub 2018 Sep 6.

Department of Orthopaedic Surgery, University of Virginia, Charlottesville, VA.

Background: Pigmented villonodular synovitis (PVNS) is a locally destructive histiocytic proliferation most commonly occurring in the knee. Extensive local joint destruction can indicate the need for a total knee arthroplasty (TKA). The objective of this study is to evaluate PVNS of the knee as a risk factor for complication after TKA. Read More

BMC Musculoskelet Disord 2018 Sep 19;19(1):339. Epub 2018 Sep 19.

Division of orthopaedic surgery, Huashan Hospital, Fudan University, Shanghai, 200040, China.

Background: To explore and evaluate the predictive value of preoperative Neutrophil-lymphocyte ratio (NLR) on the recurrence of pigmented villonodular synovitis (PVNS) of the knee joint treated by arthroscopic surgery combining local radiotherapy.

Methods: Sixty pathological-proven PVNS cases of the knee joint in our department from April 2006 to March 2017 were included. All of them are treated by arthroscopic synovectomy combined with adjuvant radiotherapy. Read More

Surg Oncol 2018 Sep 3;27(3):544-550. Epub 2018 Jul 3.

Orthopaedic Surgery, Leiden University Medical Center, Leiden, the Netherlands. Electronic address:

Aim: Current development of novel systemic agents requires identification and monitoring of extensive Tenosynovial Giant Cell Tumours (TGCT). This study defines TGCT extension on MR imaging to classify severity.

Methods: In part one, six MR parameters were defined by field-experts to assess disease extension on MR images: type of TGCT, articular involvement, cartilage-covered bone invasion, and involvement of muscular/tendinous tissue, ligaments or neurovascular structures. Read More

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2018 10;32(10):1297-1301

Department of Orthopedics/Sports Medicine Center, the First Affiliated Hospital of Army Medical University (the Third Military Medical University), Chongqing, 400038,

Objective: To investigate the effectiveness of tibio-talo-calcaneal arthrodesis with full thread headless compression screws via combined minimal incisions.

Methods: Between January 2012 and December 2016, 36 patients (36 feet) with ankle diseases underwent tibio-talo-calcaneal arthrodesis with parallel double thread headless compression screws via minimal anterior and lateral oblique incisions. There were 14 males and 22 females with an average age of 53. Read More

BMC Musculoskelet Disord 2018 Sep 11;19(1):330. Epub 2018 Sep 11.

Department of Orthopedic and Trauma Surgery, Medical Center - Albert-Ludwigs-University of Freiburg, Faculty of Medicine, Albert-Ludwigs-University of Freiburg, Freiburg im Breisgau, Germany.

Background: Diffuse pigmented villonodular synovitis (PVNS) of the knee is a rare proliferative joint disease associated with high recurrence rates following surgical treatment. Intra-articular joint instability in conjunction with PVNS implies complex reconstructive strategies due to the destructive nature of the disease.

Case Presentation: Here, we present the case of a young patient with refractory PVNS and a chronic ipsilateral anterior cruciate ligament (ACL) rupture. Read More

Adv Radiat Oncol 2018 Jul-Sep;3(3):240-244. Epub 2018 Feb 26.

Department of Radiation Oncology, University of Muenster, Muenster, Germany.

Purpose: Radiation therapy (RT) is a common treatment for benign diseases in Germany. Because the treatment concepts are inconsistent, we conducted this pattern-of-care study on behalf of the German Cooperative Group on Benign Diseases to evaluate treatment standards in Germany.

Methods And Materials: Questionnaires were mailed to all radiation therapy facilities in Germany. Read More

Histopathology 2019 Jan 11;74(2):332-340. Epub 2018 Nov 11.

Department of Cell and Chemical biology, Leiden University Medical Center, Leiden, the Netherlands.

Aims: Localised- and diffuse-type tenosynovial giant cell tumours (TGCT) are regarded as different clinical and radiological TGCT types. However, genetically and histopathologically they seem indistinguishable. We aimed to correlate CSF1 expression and CSF1 rearrangement with the biological behaviour of different TGCT-types with clinical outcome (recurrence). Read More

J Foot Ankle Surg 2018 Nov - Dec;57(6):1263-1266. Epub 2018 Aug 23.

Assistant Professor, Department of Orthopaedic Surgery, Stony Brook University Hospital, Stony Brook, NY. Electronic address:

Pigmented villonodular synovitis mostly affects the knee and other large joints such as the hip. Although the disease is most commonly found in adult patients aged 30 to 40 years, rare cases in children and the elderly have been reported. We present the case of an 11-year-old female who was found to have biopsy-proven pigmented villonodular synovitis in her subtalar joint in 2012. Read More

Acta Reumatol Port 2018 Apr-Jun;43(2):151-153

Instituto Português de Oncologia, Porto.

Epithelioid sarcoma is a rare mesenchymal neoplasm characterized by aggregates of epithelioid cells. Intra-articular occurrence is exceedingly rare with only few reports described in the literature. A 22 year-old man presented a progressive mechanical knee pain. Read More

Int J Surg Case Rep 2018 26;50:28-31. Epub 2018 Jul 26.

Department of Trauma and Orthopaedic Surgery, Ibn Sina University Hospital, Faculty of Medicine, Mohammed V University, Rabat, Morocco.

Introduction: Rice bodies are described as fibrin bodies usually found among patients with inflammatory joint diseases, tuberculous arthritis, and tuberculous tenosynovitis, but they are rarely found among non-tuberculosis patients.

Case Presentation: We report a case of a 69-year-old with a 2-year history of swelling and pain of the thenar eminence of the left hand with paresthesia in the territory of the median nerve. Surgical exploration revealed multiple rice bodies. Read More

J Belg Soc Radiol 2018 Jan 31;102(1):11. Epub 2018 Jan 31.

Centre Hospitalier Universitaire, Liège, BE.

Acta Ortop Bras 2018 May-Jun;26(3):183-186

. Institute of Orthopedics and Traumatology, Hospital das Clinicas (HCFMUSP), Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil.

Objectives: Several cases of bilateral diffuse pigmented villonodular synovitis (PVNS) or tenosynovial giant cell tumor have been described in the literature. Nevertheless, some presentations are rare and differential diagnoses are necessary.

Methods: The purpose of this study was to perform a systematic review of the literature related to PVNS and to report a rare supra-patellar bilateral and focal presentation. Read More

Case Rep Orthop 2018 21;2018:7532358. Epub 2018 Jun 21.

Department of Orthopedic Surgery and Traumatology, Saint Georges University Medical Center, Balamand University, P.O. Box 166378, Achrafieh, Beirut 1100 2807, Lebanon.

Background: Pigmented villonodular synovitis is a rare pathology causing hyperplasia of the synovium. It mostly affects young populations and most commonly the knee joint. It rarely affects the posterior compartment of the knee as the case presented in this study. Read More

Clin Sarcoma Res 2018 10;8:14. Epub 2018 Jul 10.

1Division of Hematology and Oncology, University of California Los Angeles (UCLA), 2825 Santa Monica Blvd. Suite 200, Santa Monica, CA 90404 USA.

Background: Tenosynovial giant cell tumors (TGCTs) or giant cell tumors of tendon sheath are neoplasms that arise in the synovium. They can be categorized as nodular (localized) or diffuse type (D-TGCT). Historically, surgery has been the mainstay of therapy, but diffuse type disease recurs at a high rate and treatment often requires increasingly morbid procedures. Read More

Bone Joint J 2018 07;100-B(7):984-988

Assuta Ashdod University Hospital, Ashdod, Israel, affiliated to the Beer Sheva Faculty of Medicine, Beer Sheva University, Beer Sheva, Israel.

Aims: Intra-articular Yttrium (Y) is an adjunct to surgical treatment by synovectomy for patients with diffuse-type tenosynovial giant-cell tumour (dtTGCT) of the knee, with variable success rates. Clinical information is, however, sparse and its value remains unclear. We investigated the long-term outcome of patients who underwent synovectomy with and without adjuvant treatment with Yttrium. Read More

J Pediatr Orthop 2018 Sep;38(8):e482-e485

Children's Healthcare of Atlanta, Atlanta, GA.

Background: Pigmented villonodular synovitis (PVNS) is a benign proliferative synovial disorder most commonly described in adults. The purpose of this study is to describe the presentation and management of a large single-center series of pediatric patients with PVNS of the knee.

Methods: A retrospective review was performed of consecutive pediatric patients treated for PVNS at a single institution from 2001 to 2016. Read More

Radiol Case Rep 2018 Apr 4;13(2):499-502. Epub 2018 Jan 4.

Department of Radiology, University of Illinois Hospital and Health Sciences System, 1740 W Taylor St, Chicago, IL 60612, USA.

Pigmented villonodular synovitis is a benign but locally aggressive extra-articular tumor arising from the synovial membrane of tendons and bursae occurring near a joint space. Rarely, pigmented villonodular synovitis can involve the temporomandibular joint, which is emphasized in this paper. Diffuse and localized types have been described in the literature. Read More

Vet Comp Orthop Traumatol 2018 Jul 4;31(4):304-310. Epub 2018 Jun 4.

Institute of Veterinary Science, University of Liverpool plus Institute of Ageing and Chronic Disease, Liverpool, Cheshire, United Kingdom of Great Britain and Northern Ireland.

Pigmented villonodular synovitis (PVNS) is a rare benign and usually monoarticular neoplastic lesion arising from the synovium, bursae and tendon sheaths in humans, horses and dogs. Categorization for PVNS in humans includes localized and diffuse forms of PVNS and tenosynovial giant cell tumour (TGCT), although histologically they are the same. The localized form is characterized by discrete nodular lesions, the diffuse form is often intra-articular, infiltrative, affecting the entire synovium with more aggressive behaviour and TGCT occurs along tendon sheaths. Read More

Rheumatology (Oxford) 2018 Aug;57(8):1448-1452

Musculoskeletal Oncology, Department of Orthopaedics, Physical Medicine and Rehabilitation, University Hospital, LMU Munich, Munich, Germany.

Objectives: Tenosynovial giant-cell tumour or pigmented villonodular synovitis is an aggressive synovial proliferative disease, with the knee joint being the most commonly affected joint. The mainstay of therapy is surgical resection. The aim of this study was to evaluate the main patient characteristics, treatment and outcomes in a large single-centre retrospective study, focusing on meticulous aggressive open surgical procedures. Read More

Zhongguo Gu Shang 2018 Apr;31(4):373-375

Department of Spinal Surgery, the First Hospital of Jilin University, Changchun 130021, Jilin, China;

J Knee Surg 2018 May 4. Epub 2018 May 4.

Department of Orthopaedics, Orthopaedic Research Center, Poursina Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.

The purpose of this study was to evaluate and describe the clinical results of complete arthroscopic synovectomy through the four arthroscopic portals in the knees affected by diffuse pigmented villonodular synovitis (DPVNS). Between 2009 and 2012, 21 patients (15 men and 6 women) with the diffuse form of PVNS of the knee were enrolled in the study after qualification. The clinical diagnosis was confirmed by magnetic resonance imaging and postsurgical pathologic examination. Read More

J Surg Oncol 2018 Jun 3;117(8):1786-1798. Epub 2018 May 3.

Queen Elizabeth II Health Sciences Center, Halifax Infirmary, Dalhousie University, Halifax, Nova Scotia, Canada.

Bone tumors are relatively rare in the foot and ankle region. Many of them present as cystic lesions on plain films. Due to the relative rarity of these lesions and the complex anatomy of the foot and ankle region, identification of such lesions is often delayed or they get misdiagnosed and mismanaged. Read More

Int J Oral Maxillofac Surg 2018 Oct 27;47(10):1288-1294. Epub 2018 Apr 27.

Department of Pathology, Radboud University Medical Center, Nijmegen, The Netherlands. Electronic address:

Tenosynovial giant cell tumours (TGCTs) are benign lesions affecting synovial joints. The classified subtypes are localized and diffuse. They seldom occur in the temporomandibular joint (TMJ). Read More

Eur J Orthop Surg Traumatol 2018 Oct 26;28(7):1375-1380. Epub 2018 Apr 26.

Zagazig University, Zagazig, Egypt.

Background: Pigmented villonodular synovitis or PVNS is a benign proliferating disease of the synovium; it behaves much as a neoplastic process does.

Methods: This retrospective clinical study included 11 consecutive cases who underwent for total synovectomy combined with cementless total hip arthroplasty of PVNS of the hip joint.

Results: The mean patient preoperative hip score of Harris was 46. Read More

Acta Ortop Mex 2017 Nov-Dec;31(6):308-311

Departamento de Piel y Partes Blandas del Instituto Nacional de Cancerología. Avenida San Fernando 22, Belisario Domínguez Secc 16, 14080. Ciudad de México. México.

Introduction: Pigmented villonodular synovitis (PVNS) is a rare clinical entity with higher incidence in women (3:1) and an age of presentation between 20 and 40 years. The hip is a rare site of appearance, being involved in only 15% of all cases.

Case Report: 47-year-old male with 10 years of evolution characterized by a limited range of motion, pain associated with an increase in volume and shortening of the pelvic limb. Read More

Knee Surg Sports Traumatol Arthrosc 2018 Nov 10;26(11):3508-3514. Epub 2018 Apr 10.

Investigation Performed at the University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea.

Purpose: Pigmented villonodular synovitis (PVNS)/tenosynovial giant cell tumor (TGCT) is a benign, proliferative lesion of the synovium, the bursa, and the tendon sheath. Little is known about the anatomical distribution pattern of diffuse extra-articular PVNS/TGCT around the knee joint. In this retrospective study, anatomical distribution of PVNS/TGCT using magnetic resonance imaging (MRI) and arthroscopy was analyzed. Read More

J Am Podiatr Med Assoc 2018 Mar;108(2):140-144

Background: Pigmented villonodular synovitis (PVNS) is a rare disorder around the ankle joint. The optimal treatment for diffuse-type PVNS is still controversial because of the high incidence of recurrence. We present the clinical features of our patients and review the current diagnostic and treatment modalities. Read More

Orthop J Sports Med 2018 Mar 21;6(3):2325967118763118. Epub 2018 Mar 21.

Children's Healthcare of Atlanta, Atlanta, Georgia, USA.

Background: Pigmented villonodular synovitis (PVNS) is a benign proliferative synovial disorder most commonly described to affect the knee in adults. Literature describing PVNS in the pediatric population is limited to 2 small case series and a handful of single-patient case reports. Within these studies, only 2 patients with PVNS of the hip are described. Read More

Clin Ther 2018 Apr 24;40(4):593-602.e1. Epub 2018 Mar 24.

Orthopaedic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York.

Purpose: Little is known about the burden of illness in patients with tenosynovial giant cell tumors (TGCT), which are rare, typically benign, lesions of the synovial tissue including giant cell tumor of the tendon sheath (GCT-TS) and pigmented villonodular synovitis (PVNS). The objective of this study was to describe health care resource use and costs for patients with GCT-TS and PVNS, which are rare and typically benign TGCT.

Methods: A retrospective cohort study design was used to analyze administrative claims for adult commercial and Medicare Advantage health plan enrollees with evidence of GCT-TS and PVNS from January 1, 2006 through March 31, 2015. Read More

Lancet Oncol 2018 May 20;19(5):584-586. Epub 2018 Mar 20.

Orthopaedic Department, University Hospital of Nantes, Hôtel-Dieu, 44093 Nantes Cedex 1, France; UMR 1238, Laboratory of Bone Sarcomas and Remodelling of Calcified Tissues, University of Nantes, Nantes, France; INSERM, Sarcoma Research Unit, University of Sheffield, Sheffield, UK. Electronic address: