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J Surg Oncol 2022 Jun 23. Epub 2022 Jun 23.

Department of Orthopedic Surgery, Leiden University Medical Center, Leiden, The Netherlands.

Background And Objectives: Surgery is the mainstay of treatment for tenosynovial giant cell tumors (TGCTs). However, achieving a cure through surgery alone remains challenging, especially for the diffuse-type (D-TGCT).

Methods: Our goal was to describe the surgical management of patients with D-TGCT related to large joints, treated between 2000 and 2020. Read More

Cureus 2022 May 18;14(5):e25094. Epub 2022 May 18.

Radiology, King Salman Hospital, Riyadh, SAU.

This report describes the unique case of an intra-articular lipoma in a 34-year-old male. The patient presented with a history of chronic knee pain associated with an intermittent sensation of the knee giving way. Physical examination and initial radiographic imaging were unremarkable. Read More

J West Afr Coll Surg 2020 Jul-Sep;10(3):45-48. Epub 2022 May 4.

Department of Orthopaedics and Trauma Surgery, National Orthopaedic Hospital, Igbobi-Lagos, Nigeria.

Pigmented villonodular synovitis (PVNS) is a rare proliferative disorder affecting the synovial membranes of joints, bursae, and tendons. The knee joint is one of the most common locations for an intra-articular type of PVNS and this is usually of the diffuse type of PVNS or diffuse pigmented villonodular synovitis (DPVNS). DPVNS tends to be more associated with affectation of contiguous structures. Read More

Q J Nucl Med Mol Imaging 2022 Jun 16. Epub 2022 Jun 16.

Department of Nuclear Medicine University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.

Radiosynoviorthesis (RSO) is a decades known, effective intra-articular nuclear medicine local therapy, with few rare side-effects, in which inflamed synovial membrane is treated by means of colloidal beta-emitters. There are major variations worldwide in terms of acceptance, frequency of use and approved indications for this procedure. Thus, reliable figures that reflect reality are only available for a few countries. Read More

Q J Nucl Med Mol Imaging 2022 Jun 16. Epub 2022 Jun 16.

Department of Nuclear Medicine, Northwest Clinics, Alkmaar, The Netherlands.

Radiosynoviorthesis (RSO) or radiation synovectomy has been practiced for more than half a century, but in many parts of the world, it is still relatively unknown and not used to its full potential in the standard care for chronic, persistent or recurrent synovitis. The working mechanism of RSO is simple yet elegant. Radiopharmaceutical particles are, after injection in the affected synovial joint, gobbled up by phagocytizing subsynovial inflammatory cells. Read More

J Ultrasound Med 2022 Jun 13. Epub 2022 Jun 13.

Department of Medical Ultrasonics, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.

Objectives: This is a prospective study to evaluate the clinical value of high-frequency ultrasound (HFUS), superb microvascular imaging (SMI), and contrast-enhanced ultrasound (CEUS) in differentiation of pigmented villonodular synovitis (PVNS) and highly active rheumatoid arthritis (RA).

Methods: Twenty PVNS patients and 24 active RA patients were selected to undergo HFUS, SMI, and CEUS examinations. The characteristics of HFUS, SMI, and CEUS in PVNS and RA were compared, and the differential diagnosis performances of HFUS, SMI, and CEUS in PVNS and RA were evaluated by receiver operating characteristic (ROC) analysis. Read More

JBJS Essent Surg Tech 2022 Jan-Mar;12(1). Epub 2022 Mar 21.

Department of Orthopaedics and Rehabilitation, Yale School of Medicine, New Haven, Connecticut.

Tenosynovial giant cell tumor (T-GCT) and pigmented villonodular synovitis (PVNS) are interchangeable terms for an uncommon benign proliferation of synovial tissue. Although neoplastic and inflammatory origins have been hypothesized, the etiology of this condition is unknown. There is controversy regarding surgical treatment, as the open and arthroscopic approaches to synovectomy have shown comparable reported outcomes in the literature. Read More

BMC Musculoskelet Disord 2022 Jun 6;23(1):542. Epub 2022 Jun 6.

Department of Orthopaedic, Kaohsiung Veterans General Hospital, 386, Ta-Chung 1st Rd, Kaohsiung, Taiwan, Republic of China.

J Am Acad Orthop Surg Glob Res Rev 2022 Jun 6;6(6). Epub 2022 Jun 6.

From the Weill Cornell Medical College, New York, NY (Honig) and the Department of Orthopaedic Surgery, The Johns Hopkins University, Baltimore, MD (Dr. Harris, Dr. Sabharwal, Dr. Levin, and Dr. Honcharuk).

A 12-year-old boy presented to the pediatric emergency department with a 5-day history of atraumatic, progressively worsening right hip pain and inability to ambulate. He was afebrile and had elevated inflammatory markers (Erythrocyte Sedimentation Rate [ESR]: 42 mm/hr, C-Reactive Protein [CRP]: 6.6 mg/dL) with a normal white blood cell count of 6050 cells/mm3. Read More

Cureus 2022 Apr 29;14(4):e24595. Epub 2022 Apr 29.

Orthopaedics, Institute of Medical Sciences and SUM Hospital, Bhubaneswar, IND.

Pigmented villonodular synovitis (PVNS) is a locally aggressive benign tumour of the synovial membrane and tendon sheath. The unique presentation of this tumour is hemosiderin deposition with synovial proliferation. Depending on the situation, surgical excision is always the first line of treatment with adjuvant radiotherapy. Read More

Int J Health Sci (Qassim) 2022 May-Jun;16(3):64-66

Department of Orthopedics, College of Medicine, King Saud University, Riyadh, Saudi Arabia.

Pigmented villonodular synovitis (PVNS) is a rare and benign lesion of unknown cause. Most cases reported in adult age patients. The diagnosing of PVNS is more difficult in old age patients and might be confused with osteoarthritis. Read More

Front Surg 2022 28;9:760704. Epub 2022 Apr 28.

Department of Orthopedics, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.

Pigmented villonodular synovitis (PNVS) is a rare and disabling disease that is thought to occur mostly in the knee joint. Here, the authors first present a unique case of PNVS occurring at the sacroiliac joint. The patient complained of sacroiliac joint pain with mild swelling. Read More

Malays Orthop J 2022 Mar;16(1):126-129

Department of Orthopaedics, Topiwala National Medical College, Mumbai, India.

Tuberculosis is known to be a great mimicker, and it can present in a myriad of ways, which often result in an incorrect diagnosis. In a country that is endemic to tuberculosis, the presentation can take many forms ranging from tumour to trauma. We present a case of Baker's cyst that was provisionally diagnosed as pigmented villonodular synovitis (PVNS) of the knee and eventually turned out to be tuberculous arthritis. Read More

Magn Reson Imaging Clin N Am 2022 May 13;30(2):339-350. Epub 2022 Apr 13.

Department of Radiology, UCSD Health System, University of California, HCOP MRI, 408 Dickinson Street, San Diego, CA 92103-8226, USA.

Intra-articular masses affecting the knee joint are uncommon lesions that encompass a range of neoplastic and nonneoplastic disorders. A joint mass limited to a single articulation is most commonly related to neoplastic or focal proliferative disease, whereas masses affecting multiple articulations are typically caused by underlying inflammatory arthritides, metabolic abnormalities, or systemic deposition disorders. This article focuses on those masses that present in a monoarticular fashion, emphasizing the lesions that most commonly affect the knee joint. Read More

Foot Ankle Spec 2022 Apr 13:19386400221088456. Epub 2022 Apr 13.

Department of Orthopaedic Surgery, Duke University, Durham, North Carolina.

Background: Pigmented villonodular synovitis (PVNS) is a benign proliferative disease affecting tendon sheaths and synovial tissue. Pigmented villonodular synovitis in the foot and ankle has a high rate of recurrence, which can be destructive if incompletely removed. This case series analyzes functional outcomes after PVNS operative resection with an anterior ankle capsular reconstruction, using a novel technique. Read More

Sci Rep 2022 04 6;12(1):5763. Epub 2022 Apr 6.

Department of Neurosurgery, West China Hospital, Sichuan University, 37 Guoxue lane, Chengdu, 610041, Sichuan, China.

Most studies on pigmented villonodular synovitis (PVNS) of the temporomandibular joint (TMJ) with skull base extension mostly are case report. Here, we summarize the clinical features, treatments, and outcomes of PVNS of the TMJ with skull base extension in a large case series. We reviewed the clinical information relating to patients diagnosed with PVNS of the TMJ with skull base extension information of patients in our center between 2011 and 2020. Read More

Radiol Case Rep 2022 May 27;17(5):1798-1802. Epub 2022 Mar 27.

Department of Radiology, E Hospital, Ha Noi, Vietnam.

Pigmented villonodular synovitis is a rare proliferative process, especially in children. Pigmented villonodular synovitis can affect the synovial joint, tendon sheaths, and bursa membranes. Within synovial joint involvement, it is commonly seen in the knee joint but hip, ankle, shoulder, wrist, and other joints can be involved. Read More

Front Immunol 2022 21;13:820046. Epub 2022 Feb 21.

Department of Clinical Immunology and Rheumatology, and Immunogenomics and Inflammation Research Unit, University of Lyon, Hôpital Edouard Herriot, Lyon, France.

Rheumatoid arthritis (RA) is a chronic inflammatory disease that leads to joint destruction and bone erosion. Even if many treatments were developed with success in the last decades, some patients fail to respond, and disease chronicity is still a burden. Mechanisms involved in such resistance may include molecular changes in stromal cells. Read More

Sci Rep 2022 03 9;12(1):3832. Epub 2022 Mar 9.

Immunogenomics and Inflammation Research Unit, Edouard Herriot Hospital, Hospices Civils de Lyon, 5 Place d'Arsonval, 69003, Lyon, France.

Pigmented villonodular synovitis (PVNS) is a rare inflammatory articular disease sharing common characteristics with rheumatoid arthritis (RA), notably hyperplasia of the synovium due to a hyperproliferation of synoviocytes, and with cancer owing to mutations of the CSF1/M-CCSF gene. Targeting synovium hyperplasia by the local delivery of Cadmium (Cd) has been already tested in vitro and in vivo models of RA and could be applied to PVNS. PVNS and RA synoviocytes were exposed to low doses of Cd. Read More

BMC Musculoskelet Disord 2022 Mar 3;23(1):197. Epub 2022 Mar 3.

Department of Orthopaedic, Kaohsiung veterans general hospital, 386, Ta-Chung 1st Rd, Kaohsiung, Taiwan, Republic of China.

Background: Diffuse pigmented villonodular synovitis (DPVNS) is a challenging tumor-like disorder that mainly occurs in the anterior aspect of the knee joint. The growth may sometimes extend to the posterior knee joint. Surgical excision is the mainstream treatment for DPVNS, and the posterior approach of tumor excision is adopted when the dominant tumor shows posterior extension. Read More

BMC Musculoskelet Disord 2022 Mar 2;23(1):192. Epub 2022 Mar 2.

Department of Sports Medicine, Peking University Third Hospital; Institute of Sports Medicine of Peking University; Beijing Key Laboratory of Sports Injuries, 49 North Garden Rd, Haidian District, 100191, Beijing, PR China.

Background: Though radiotherapy has been widely used for knee pigmented villonodular synovitis (PVNS), there is few literatures about radiotherapy for the treatment of PVNS hip. Thus, the purpose of this study was to analyze the clinical outcomes of endoscopic synovectomy with/without radiotherapy postoperatively of PVNS hip.

Methods: We performed a retrospective study of patients who underwent endoscopy in our hospital from November 2010 to January 2021. Read More

J Can Chiropr Assoc 2021 Dec;65(3):344-349

Graduate Student, Sport Sciences RCCSS (C) SSRP program.

Objective: To present the diagnostic, clinical, and radiological features of pigmented villonodular synovitis (PVNS), create awareness of this rare condition, and provide guidance for conservative healthcare practitioners for further referral and appropriate management.

Case Presentation: We present the case of a 41-year-old recreational runner who presented to the clinic with anterior hip pain of one year duration. Following a clinical history and examination, the patient was diagnosed with clinical femoroacetabular impingement. Read More

J Knee Surg 2022 May 21;35(6):597-606. Epub 2022 Feb 21.

The Center for Orthopedic Research and Eduction (CORE) Institute, Phoenix, Arizona.

Intra-articular tumors of the knee are most commonly benign. Overall, this is a relatively rare clinical presentation. The differential diagnosis includes pigmented villonodular synovitis, synovial chondromatosis, lipoma arborescens, synovial hemangioma, and very rarely primary sarcoma (synovial sarcoma being the most common). Read More

Onco Targets Ther 2022 13;15:53-66. Epub 2022 Jan 13.

Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Tenosynovial giant cell tumor (TGCT) is a neoplasm of the joint synovium that can have severe impacts on joint mobility, function, and quality of life. Traditionally, treatment modalities included partial or complete surgical synovectomy, radiotherapy (typically as an adjunct to surgery), and watchful monitoring (no medical or surgical intervention). However, these approaches have been met with varying degrees of success and high recurrence rates, as well as onerous complications and clinical sequelae. Read More

Malays Orthop J 2021 Nov;15(3):122-126

Department of Pathology, Universiti Malaysia Sarawak, Kota Samarahan, Malaysia.

Pigmented villonodular synovitis (PVNS) is a benign but rare proliferative disorder of the synovium. It commonly occurs in the adult population and usually presents as a monoarticular disease. There are two types of PVNS, namely the localised and diffused type. Read More

Acta Reumatol Port 2021 Oct-Dec;46(4):370-371

Serviço de Radiologia, Centro Hospitalar Universitário São João, Porto, Portugal.

Orthop Surg 2022 Feb 16;14(2):290-297. Epub 2021 Dec 16.

Department of Bone Oncology, Tianjin Hospital, Tianjin, China.

Objective: To propose a simple and practical clinical classification for tenosynovial giant cell tumor (TGCT) of the knee.

Methods: A retrospective study was conducted to verify the value and significance of this clinical classification. TGCT growth patterns, knee joint capsule, and bone erosion were applied to establish this novel clinical classification. Read More

J Am Acad Orthop Surg Glob Res Rev 2021 12 9;4(12). Epub 2021 Dec 9.

From the Rutgers Robert Wood Johnson Medical School, Piscataway, NJ (Mr. Chandra); Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, PA (Mr. Chandra and Dr. Abraham); Rothman Orthopaedic Institute, Philadelphia, PA (Mr. Chandra, Ms. Agarwal, Ms. Donahue and Dr. Abraham); Drexel University School of Medicine, Philadelphia, PA (Ms. Agarwal); Biostatistics and Bioinformatics Facility, Fox Chase Cancer Center, Philadelphia, PA (Dr. Handorf) and the Sarcoma Center of Excellence, Capital Health Medical Center, Pennington, NJ (Dr. Abraham).

Background: Whether arthroscopic or open surgical management for diffuse-type tenosynovial giant cell tumor (D-TGCT) of the knee is associated with a lower rate of recurrence is unknown.

Methods: PubMed, Scopus, Web of Science, Cochrane, and EMBASE were searched on December 3, 2020. Retrospective studies that reported on recurrence rates for arthroscopic versus open management of D-TGCT were included. Read More

J Wrist Surg 2021 Dec 9;10(6):533-535. Epub 2021 Mar 9.

The Hand Surgery Clinics, Giridarshan Society, Pune, Maharashtra, India.

Giant cell tumors of tendon sheath are classified according to their clinical presentation as localized or diffuse, and they may occur at intra-articular or extra-articular locations. Although magnetic resonance imaging is mandatory and sufficient for diagnosis in many cases, histological examination is needed to confirm the diagnosis. Complete surgical resection is the mainstay of treatment. Read More

Ther Adv Musculoskelet Dis 2021 25;13:1759720X211055309. Epub 2021 Nov 25.

Servicio de Reumatología, Hospital General Universitario Gregorio Marañón, Madrid, SpainInstituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain.

Objectives: Radiosynovectomy can be an effective treatment for difficult-to-treat monoarthritis resistant to systemic and local standard therapy. The objective of our study was to determine predictors of good response to radiosynovectomy in routine care and give an overview of this underused technique.

Methods: Retrospective observational study of all the patients who underwent radiosynovectomy during a 6-year inclusion period. Read More