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Radiol Case Rep 2020 Aug 24;15(8):1335-1338. Epub 2020 Jun 24.

Department of Radiology, National Orthopaedic Hospital Cappagh, Finglas, Dublin 11, Ireland.

Pigmented villonodular synovitis is a rare benign proliferative disease of synovial membranes, causing villonodular synovial hyperplasia and hemosiderin deposition. Its intra-articular forms most commonly affect the knee and less commonly the hip. PVNS of the hip is most common in the second to fifth decades and presentation is typically with pain and occasionally joint dysfunction. Read More

Iowa Orthop J 2019 ;39(2):73-75

Royal Orthopaedic Hospital NHS Foundation Trust, Birmingham, UK.

Pigmented Villonodular Synovitis (PVNS) of the shoulder is rare. We present a patient with locally recurrent tonsillar squamous cell carcinoma (SCC) and newly identified soft tissue lesion of the right shoulder exhibiting similar focal FDG-PET CT uptake. Biopsy demonstrated features consistent with pigmented villonodular synovitis (PVNS). Read More

J Clin Neurosci 2020 Jun 4. Epub 2020 Jun 4.

Department of Neurologic Surgery, Mayo Clinic, Rochester, MN, USA; Department of Radiology, Mayo Clinic, Rochester MN, USA. Electronic address:

Spinal solitary fibrous tumor/hemangiopericytoma (SFT/HPC) is a rare mesenchymal malignancy. Radiographically, SFT/HPCs have a mutable appearance, with irregular borders, heterogeneous contrast enhancement, and variable but frequently hypointense T2 signal. We report a series of 5 neurosurgically managed spinal SFT/HPCs treated at our institution, with particular attention to 3 lesions demonstrating marked T2-hypointensity and differential diagnosis for the unusual finding of a "T2 dark" spinal lesion. Read More

Curr Oncol Rep 2020 Jun 4;22(6):63. Epub 2020 Jun 4.

Department of Orthopaedic Surgery, David Geffen School of Medicine, UCLA, Los Angeles, CA, 90055, USA.

Purpose Of Review: Pigmented villonodular synovitis (PVNS) or tenosynovial giant cell tumor (TGCT) encompasses a wide spectrum of disease and is divided into localized and diffuse variants. Surgical resection remains the principal treatment for nearly all localized type disease and most diffuse type. Recent mechanistic understanding of the disease led to drug discovery that has opened new avenues for patients with recalcitrant disease. Read More

Cureus 2020 Apr 25;12(4):e7832. Epub 2020 Apr 25.

Orthopaedics, General Hospital of Nikaia "Saint Panteleimon", Piraeus, GRC.

Pigmented villonodular synovitis (PVNS) is caused by a proliferation of the synovial membrane and can be a rare cause of pain and locking of the knee. In its localized form, it can be removed arthroscopically. We describe in detail a step-by-step arthroscopic technique applied to treat a 27-year-old patient who had been suffering from pain and episodes of locking for a year and whose left knee MRI revealed an intra-articular mass. Read More

Drug Des Devel Ther 2020 4;14:1693-1704. Epub 2020 May 4.

Division of Medical Oncology, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.

Tenosynovial giant cell tumor (TGCT) is a rare benign tumor that involves the synovium, bursa, and tendon sheath, resulting in reduced mobility of the affected joint or limb. The current standard of care for TGCT is surgical resection. However, some patients have tumor recurrence, present with unresectable tumors, or have tumors that are in locations where resection could result in amputations or significant debility. Read More

Clin Pract Cases Emerg Med 2020 May 24;4(2):225-226. Epub 2020 Feb 24.

Broward Health, Department of Emergency Medicine, Coral Springs, Florida.

A 19-year-old Asian male presented to our emergency department with atraumatic right hip pain radiating to the right groin associated with pain on ambulation. Magnetic resonance imaging of the right hip with and without contrast revealed the diagnosis. Pigmented villonodular synovitis is a rare, monoarticular benign tumor originating from the synovium of the joint. Read More

Adv Ther 2020 Jun 11;37(6):2813-2828. Epub 2020 May 11.

Novartis Healthcare Pvt. Ltd., Hyderabad, India.

Introduction: Pigmented villonodular synovitis (PVNS), also known as giant-cell tumour of the tendon sheath (GCTT), is a rare, benign proliferative tumour affecting the inner lining of synovial joints and tendon sheets. Information on treatment needs of PVNS patients to inform drug development is currently scarce. We conducted an exploratory qualitative study with PVNS patients to generate insights into the objective and emotional aspects related to their medical journey and experiences of living with this disease. Read More

Medicine (Baltimore) 2020 Apr;99(16):e19856

Department of Orthopaedic Surgery, Wuhan Fourth Hospital, Wuhan City, China.

Rationale: Pigmented villonodular synovitis is a rare disease which may involve any joints. It has localized and diffuse forms, and the latter is more aggressive with a higher recurrence rate. Different treatments are applied to each form of the disease, but there is no standard surgical procedure or any consensus on whether adjuvant therapy should be used. Read More

Zhongguo Gu Shang 2020 Jan;33(1):78-80

Department of Bone and Joint Surgery, the First Hospital of Jilin University, Changchun 130021, Jilin, China.

J Clin Med 2020 Feb 22;9(2). Epub 2020 Feb 22.

Department of Nuclear Medicine, Inselspital, Bern University Hospital, 3010 Bern, Switzerland.

Pigmented villonodular synovitis (PVNS) of the ankle is a very rare, locally aggressive, proliferative disorder. Although surgical excision represents the standard curative treatment, the PVNS relapse rate is high. We present our study of five young athletes (range 20-36 years) with a histopathological diagnosis of PVNS of the ankle, who were treated by surgery and adjuvant radiosynoviorthesis (RSO). Read More

Arthroscopy 2020 06 13;36(6):1587-1598. Epub 2020 Feb 13.

Sports Medicine, Department of Orthopaedic Surgery, Massachusetts General Hospital, Partners Heath System, Boston, Massachusetts, U.S.A.

Purpose: To analyze mid-term outcomes after arthroscopic synovectomy of both diffuse and nodular hip pigmented villonodular synovitis (PVNS).

Methods: This is a retrospective case series of patients that underwent hip arthroscopy for hip PVNS with a single senior surgeon between 2007 and 2016. Inclusion criteria were magnetic resonance imaging evidence, arthroscopic visualization, and/or histologic confirmation of PVNS; and a minimum of 3 years of follow-up. Read More

Head Neck 2020 Feb 10. Epub 2020 Feb 10.

Department of Pathology, University of Texas M. D. Anderson Cancer Center, Houston, Texas.

Background: The temporomandibular joint (TMJ) harbors a myriad of pathologic alterations including arthritides and benign and malignant neoplasms.

Methods: Herein, we describe our institutional experience of some uncommon and unusual synovial pathologies of the TMJ along with a review of literature. We searched through the archives of department of pathology and institutional electronic medical record for specimens of TMJ between 1999 and 2019. Read More

Rev Esp Cir Ortop Traumatol 2020 May - Jun;64(3):199-205. Epub 2020 Jan 21.

Departamento de Cirugía Ortopédica y Traumatología, Clínica Universidad de Navarra, Pamplona, Navarra, España.

Objective: Tenosynovial giant cell tumour (TGCT) is locally aggressive entity affecting young people (around 4 decade of life) and can cause joint destruction. It could be nodular or diffuse. These two varieties are histological and genetically similar, but present a different prognosis. Read More

Skeletal Radiol 2020 Jun 7;49(6):921-928. Epub 2020 Jan 7.

Department of Radiology, Thomas Jefferson University Hospital, 132 S. 10th Street, 10th Floor, Philadelphia, PA, 19107, USA.

Objective: A variety of benign and neoplastic lesions can affect the synovium, including pigmented villonodular synovitis (PVNS) and synovial chondromatosis. Prior to surgical resection, accurate characterization of synovial lesions is necessary for appropriate treatment planning. Additionally, recent advances in potential medical therapies for PVNS could decrease or eliminate the need for surgery in some cases. Read More

Arthrosc Tech 2019 Dec 9;8(12):e1495-e1499. Epub 2019 Nov 9.

Department of Orthopaedic Surgery, Tohoku Orthopaedic Clinic, Kamiyagari, Izumi-ku, Sendai-city, Japan.

We orthopaedic surgeons are not familiar with the popliteus bursa. It is defined as the expansion in the synovial membrane of the posterolateral part of the knee that lies between the lateral meniscus and the tendon of the popliteus muscle. The popliteus bursa extends approximately 1 cm distal to the joint line and has 4 borders; the medial border is the peripheral margin of the lateral meniscus, the lateral border is the popliteus tendon, and the superior and inferior borders are formed by 2 fascicles. Read More

Arthrosc Tech 2019 Nov 11;8(11):e1309-e1312. Epub 2019 Oct 11.

Department of Orthopaedics and Traumatology, North District Hospital, Hong Kong SAR, China.

Pathologies within the fat pad can have either intrinsic or extrinsic causes. Most of them are the consequences of trauma and degeneration, but inflammatory and neoplastic diseases can arise in the fat pad. Pigmented villonodular synovitis is the most common space-occupying lesion of the Hoffa fat pad, followed by ganglion. Read More

Pediatr Radiol 2020 04 19;50(4):509-515. Epub 2019 Dec 19.

Department of Pediatric Surgery, Children's Hospital, Helsinki University Hospital and University of Helsinki, P.O. Box 347, 00029 HUS, Helsinki, Finland.

Background: Intra-articular venous malformations of the knee are an uncommon cause of unilateral knee pain in children. Timely diagnosis is important because lesions with intrasynovial involvement can lead to joint space hemorrhage and secondary cartilage damage.

Objective: To describe our tertiary center's experience of diagnostics and typical magnetic resonance imaging (MRI) findings. Read More

Foot Ankle Surg 2019 Dec 5. Epub 2019 Dec 5.

Department of Orthopaedic Surgery, Nara Medical University, 840, Shijo-cho, Kashihara, Nara 634-8521, Japan.

Background: Diffuse tenosynovial giant cell tumors (TGCT) are more likely to occur in the hindfoot and tend to recur after surgical excision. We performed a pooled analysis of hindfoot TGCT cases to identify factors associated with local recurrence and functional outcomes.

Methods: We retrospectively reviewed medical records of 33 patients diagnosed with TGCT (15, localized cases; 18 diffused cases) of the hindfoot between 1998 and 2017. Read More

Rheumatol Int 2020 Apr 9;40(4):657-661. Epub 2019 Dec 9.

Department of Orthopedic Surgery, Myongji Hospital, Hanyang University College of Medicine, 55, Hwasu-ro 14beon-gil, Deogyang-gu, Goyang-si, Gyeonggi-do, 10475, South Korea.

Pigmented villonodular synovitis (PVNS) is a proliferative disease that develops in the synovium of joints, especially the knee joints. A 52-year-old man visited our hospital with left knee pain, swelling and symptoms of collapse. Twenty-one years earlier, he had undergone anterior cruciate ligament (ACL) reconstruction using an active bioprosthetic composite (ABC) as an artificial ligament. Read More

J Ultrason 2019 Nov 30;19(78):212-221. Epub 2019 Sep 30.

University Surgical Clinic "St. Naum Ohridski" Skopje, University "Ss. Cyril and Methodius", Skopje, Macedonia.

High-resolution ultrasonography has many advantages in the imaging of the musculoskeletal system, when compared to other imaging methods, particularly in superficial, easily accessible parts of the body. It is a perfect diagnostic tool for visualizing the most common pathologies of the musculoskeletal system, including the bursae. Inflammation of bursae is frequent, and it can mimic other diseases of the musculoskeletal system. Read More

Ann Nucl Med 2020 Feb 12;34(2):94-101. Epub 2019 Nov 12.

Faculty of Health Sciences, Wroclaw Medical University, Kazimierza Bartla 5, 50-996, Wrocław, Poland.

Objective: The aim of this study was to assess the treatment results of Y radiation synovectomy for chronic exudative synovitis of knee joints.

Methods: The retrospective data consist of 394 consecutive knee radiation synovectomies performed using 6 mCi (222 MBq) of Y. The assessment included 3-point custom pain and joint mobility scale, evaluation of joint's circumference, binary joint's temperature evaluation, patellar ballottement test, indications for puncture and its volume in applicable cases. Read More

Med J Armed Forces India 2019 Oct 16;75(4):467-471. Epub 2017 Dec 16.

Graded Specialist (Orthopaedics), Military Hospital Jodhpur, Rajasthan, India.

Paediatric joint pain and swelling is a frequent presentation. The clinical profile and relevant laboratory investigations often lead to the correct diagnosis; however some patients present a diagnostic conundrum. Pigmented villonodular synovitis (PVNS) is a rare entity that may afflict children and be easily missed. Read More

Skeletal Radiol 2020 Mar 28;49(3):483-489. Epub 2019 Oct 28.

Department of Radiology, Mayo Clinic, Charlton Building North, 1st Floor, 200 First Street SW, Rochester, MN, 55905, USA.

Diffuse-type tenosynovial giant cell tumor (TSGCT) is a rare, locally aggressive neoplasm. It most commonly occurs in the knee, followed by the hip, and has distinctive imaging features, including mass-like foci of low T2 signal intensity, "blooming" on gradient-echo MRI, and pronounced uptake on FDG PET/CT. Histologically, TSGCT demonstrates a neoplastic population of mononuclear cells admixed with hemosiderin-laden macrophages, foamy histiocytes, inflammatory cells, and osteoclast-like giant cells. Read More

J Pak Med Assoc 2019 Oct;69(10):1568-1569

CEDAR Superspeciality Clinic, Dwarka, New Delhi, India.

Diabetes is a multisystemic and multifaceted syndrome, and its clinical impact is wide ranging and varied. The musculoskeletal complications of diabetes, too cover a broad spectrum of joints and presentations. Relatively less attention is paid, however, to the diabetic knee. Read More

J Postgrad Med 2019 Oct-Dec;65(4):233-236

Department of Pediatric Rheumatology, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey.

Pigmented villonodular synovitis (PVNS) is a rare benign disorder of a joint which affects its synovium, tendon sheaths and bursas. While most cases of PVNS are adult patients aged between 20-50 years, few afflicted children have also been reported. Clinical signs of PVNS are insidious and non-specific. Read More

Anticancer Drugs 2020 01;31(1):80-84

Medical Oncology 1, Ospedale Policlinico San Martino, University of Genova, Genova.

Tenosynovial giant cell tumour (TGCT) is a group of rare soft tissues neoplasia affecting synovial joints, bursae and tendon sheaths and is classified as localized type or diffuse type. The diffuse type (TGCT-D), also known as 'pigmented villonodular (teno)synovitis' is characterized by local aggressivity, with invasion and destruction of adjacent soft-tissue structures, and high local recurrence rate. Radical surgery remains the standard therapy while adjuvant radiotherapy may help to control local spread. Read More

J Radiol Case Rep 2019 Aug 31;13(8):31-39. Epub 2019 Aug 31.

Department of Radiation Oncology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.

Pigmented villonodular synovitis (PVNS) is a benign proliferative disorder of the synovium that usually involves joints, tendon sheaths, and bursae. It presents rarely, however, in the temporomandibular joints (TMJs). This paper reports a 59-year-old female patient with PVNS of the TMJ and its clinico-pathologic features are discussed. Read More

Br J Hosp Med (Lond) 2019 Sep;80(9):550

Consultant in Trauma and Orthopaedics, Department of Trauma and Orthopaedic Surgery, Warrington Hospital, Warrington.

Genes Chromosomes Cancer 2020 02 12;59(2):96-105. Epub 2019 Sep 12.

Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada.

Tenosynovial giant cell tumors (TGCTs) are characterized by rearrangements of CSF1, thought to drive overexpression of macrophage colony-stimulating factor (CSF1), thereby promoting tumor growth and recruitment of non-neoplastic mononuclear and multinucleated inflammatory cells. While fusions to collagen promoters have been described, the mechanism of CSF1 overexpression has been unclear in a majority of cases. Two cohorts of TGCT were investigated for CSF1 rearrangements using fluorescence in situ hybridization (FISH) and either RNA-seq or DNA-seq with Sanger validation. Read More

J Knee Surg 2019 Aug 21. Epub 2019 Aug 21.

Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, Hunan, China.

Diffuse-type pigmented villonodular synovitis is a rare benign disease that causes disorders of the knee, including erosion of subchondral bone and cyst formation, with eventual osteoarthritis. The purpose of this study was to evaluate the short-term outcomes of synovectomy and total knee replacement in patients with the diffuse type of pigmented villonodular synovitis. From November 2011 to May 2015, we performed synovectomy and total knee replacement in 28 patients with diffuse pigmented villonodular synovitis diagnosed on the basis of histopathology of biopsy specimens. Read More

Arthrosc Tech 2019 Jun 2;8(6):e641-e646. Epub 2019 Jun 2.

Sport Medicine, Department of Orthopaedic Surgery, Massachusetts General Hospital, Partners Heath System, Boston, Massachusetts, U.S.A.

Pigmented villonodular synovitis (PVNS) is a monoarticular, benign tumor arising from the synovium. Although classically treated with open synovectomy, arthroscopic treatment has demonstrated good clinical outcomes. The arthroscopic management of hip PVNS has been described as technically challenging due to difficulty obtaining the appropriate exposure. Read More

Eklem Hastalik Cerrahisi 2019 Aug;30(2):177-81

Department of Orthopedic Surgery, Nanoori Suwon Hospital, 16503 Gyeonggi-do, Republic of Korea.

Pigmented villonodular synovitis (PVNS) is a benign tumorous condition commonly found in tendon sheathes, bursa, or joint synovium. Unlike the diffuse type which invades the entire synovium of the affected joint, synovium of localized PVNS shows relatively normal appearance. It presents nonspecific symptoms and typically progresses for a long time but acute locking phenomenon or internal derangement of knee symptoms suddenly commence in early stage. Read More

World Neurosurg 2019 Sep 27;129:390-393. Epub 2019 Jun 27.

Department of Orthopaedic Surgery, Faculty of Medicine, Kagawa University, Kagawa, Japan.

Background: Spontaneous spinal epidural hematoma (SSEH) is a spinal emergency that requires early diagnosis and decompression surgery. Here, we report a case of SSEH that was difficult to differentiate from pigmented villonodular synovitis (PVS) because of combined facet joint destruction and that required gross total resection, a procedure not typically indicated for SSEH.

Case Description: A 58-year-old woman complained of sudden-onset walk disturbance after backache without any traumatic episode. Read More

ORL J Otorhinolaryngol Relat Spec 2019;81(2-3):171-182. Epub 2019 Jun 26.

Department of Otorhinolaryngology - Head and Neck Surgery, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Background/aims: To review the existing literature on pigmented villonodular synovitis (PVNS) of the temporomandibular joint (TMJ) and report a rare case of PVNS of the TMJ presenting with unilateral hearing loss.

Methods: Review of the existing literature and a description of personal experience with PVNS of the TMJ presenting with unilateral hearing loss.

Results: Review of the existing literature revealed 76 reported cases of PVNS of the TMJ. Read More

Radiol Case Rep 2019 Aug 24;14(8):934-940. Epub 2019 May 24.

University of Illinois College of Medicine, 1740 W. Taylor St., MC 931, Chicago, IL, 60612, USA.

Diffuse-type tenosynovial giant cell tumor (D-TGCT), otherwise known as pigmented villonodular synovitis, is a locally aggressive tumor which can show multiple recurrences but is rarely associated with metastasis. A handful of studies have elucidated the imaging features and clinical course in metastatic D-TGCT with malignant transformation on histology. However, only 5 cases of metastatic D-TGCT with benign histological features have been reported in the literature, with the clinical course and prognosis reported in only 1 case. Read More

Tohoku J Exp Med 2019 06;248(2):87-97

Division of Orthopedic Surgery, Niigata University Graduate School of Medical and Dental Sciences.

Bone and soft tissue tumors are derived from mesenchymal cells, and they are hard to treat. Receptor-activator of nuclear factor-kappa B ligand (RANKL) is an essential cytokine for osteoclast differentiation and activation and is expressed on the surface of osteoblasts or stromal cells. In this study, to explore the potential of denosumab treatment for soft tissue tumors, we analyzed the expression profiles of RANKL mRNA in 425 tumor specimens of 33 histological types by real-time RT-PCR. Read More

Medwave 2019 May 27;19(4):e7641. Epub 2019 May 27.

Departamento de Ortopedia y Traumatologia, Facultad de Medicina, Pontificia Universidad Catolica de Chile, Santiago, Chile; Equipo Cirugía de Tobillo y Pie. Clínica Las Condes, Santiago Chile. Address: Departamento de Ortopedia y Traumatología, Pontificia Universidad Católica de Chile, Diagonal Paraguay 362, 3er piso. Cod. Postal: 8330077. Email:

Pigmented villonodular synovitis is a benign tumor of synovial tissue with a very low incidence. Ankle location is even less frequent. Early diagnosis and management are required to avoid irreversible functional and mechanical sequelae. Read More

Lancet Oncol 2019 06 24;20(6):877-886. Epub 2019 Apr 24.

Department of Orthopaedics, Leiden University Medical Center, Leiden, Netherlands.

Background: Diffuse-type tenosynovial giant-cell tumour is a rare, locally aggressive, and difficult-to-treat soft tissue tumour. Clinical and surgical outcomes depend on multiple factors, including preoperative diagnostic assessment, the localisation and extent of disease, and possibly the choice of treatment modalities by orthopaedic surgeons. We did a retrospective cohort study to characterise global surgical treatment protocols, and assess surgical outcomes, complications, and functional results in patients with diffuse-type tenosynovial giant-cell tumours. Read More

Indian J Pathol Microbiol 2019 Apr-Jun;62(2):353-354

Department of Radiology, Access Healthcare, Connaught Place, New Delhi, India.

Knee Surg Relat Res 2019 Mar;31(1):67-71

Department of Orthopaedic Surgery, The Orthopaedic Speciality Clinic, Pune.

Pigmented villonodular synovitis (PVNS) is a rare benign condition that is locally aggressive and may destructively invade the surrounding soft tissues and bone causing functional loss of the joint and the limb. The knee is the most affected joint (range, 28% to 70%) but involvement of the bone is not a common feature seen at this site. We present a rare case of diffuse PVNS of the knee associated with subchondral cyst of the lateral femoral condyle. Read More

J Clin Neurosci 2019 May 28;63:22-26. Epub 2019 Feb 28.

Department of Orthopaedic Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa-ku, Nagoya, Aichi 466-8550, Japan. Electronic address:

Primary tumors of the spine are uncommon compared to metastases. The objective of the study was to examine the utility of O-arm navigation-assisted surgery for a primary spine tumor. A prospective study was performed in 18 consecutive patients who underwent O-arm navigation-assisted surgery for a primary spine tumor at our hospital between 2014 and 2017. Read More

Bone Joint J 2019 Mar;101-B(3):272-280

Department of Orthopedics, Radboud University Medical Center, Nijmegen, The Netherlands.

Aims: The aim of this study was to evaluate health-related quality of life (HRQoL) and joint function in tenosynovial giant cell tumour (TGCT) patients before and after surgical treatment.

Patients And Methods: This prospective cohort study run in two Dutch referral centres assessed patient-reported outcome measures (PROMs; 36-Item Short-Form Health Survey (SF-36), visual analogue scale (VAS) for pain, and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC)) in 359 consecutive patients with localized- and diffuse-type TGCT of large joints. Patients with recurrent disease (n = 121) and a wait-and-see policy (n = 32) were excluded. Read More

J Oral Maxillofac Surg 2019 May 29;77(5):1022.e1-1022.e39. Epub 2019 Jan 29.

Professor, Department of Radiology, The Affiliated Hospital of Qingdao University, Qingdao, China. Electronic address:

Purpose: Diffuse tenosynovial giant cell tumor (TGCT) of the temporomandibular joint (TMJ) is rare. The aim of the present study was to summarize the clinical, radiologic, and pathologic features of this tumor.

Materials And Methods: Nine cases of TGCT in the TMJ region were examined. Read More

Saudi J Med Med Sci 2019 Jan-Apr;7(1):44-46. Epub 2018 Dec 14.

College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia.

Pigmented villonodular synovitis is a rare, disabling disease that usually presents in young adults. Here, the authors present a unique case of pigmented villonodular synovitis in a 60-year-old female diagnosed 20 years after the initial presentation. The patient presented with a complaint of knee pain consistent with osteoarthritis. Read More

Folia Med Cracov 2018;58(4):93-104

Human Anatomy Department, Medical University of Lublin; Radiology Department, St Johns' Cancer Center; Lublin, Poland.

Pigmented villonodular synovitis (PVNS) is a benign disease that rarely undergoes malignant transformation. There are two types of disease: localized (nodular tenosynovitis) and di used (pigmented villonodular synovitis/tenosynovitis) with intra- or extra-articular locations. The second one is limited to synovium of the burse (PVNB) or tendon sheath (PVNTS). Read More

Reumatol Clin 2019 Jan 25. Epub 2019 Jan 25.

Servicio de Reumatología, Hospital General Universitario de Ciudad Real, Ciudad Real, España.

Our hospital is the nuclear medicine referral hospital for radioisotopic synoviorthesis for all of Castilla-La Mancha.

Objective: To describe the experience in the performance of radioisotopic synoviorthesis for arthritis refractory to other treatments in our hospital.

Methodology: Observational, descriptive and cross-sectional study protocolised through the review of the database of radioisotopic synoviorthesis performed between 2007 and 2017. Read More

J Hip Preserv Surg 2018 Dec 31;5(4):443-447. Epub 2018 Oct 31.

Minimal Invasive Orthopedics Unit, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel.

This report presents a case of a 37-year-old female with a history of hip pain. Magnetic resonance arthrography revealed loose bodies within the joint and synovial hypertrophy indicative of synovial chondromatosis (SC). Hip arthroscopy revealed free chondral bodies and focal villonodular synovial proliferation. Read More

Case Rep Orthop 2018 6;2018:7698052. Epub 2018 Dec 6.

Cliniques Universitaires Saint-Luc, Service d'Orthopédie et de Traumatologie de l'Appareil Locomoteur, Avenue Hippocrate 10, B-1200 Brussels, Belgium.

Noonan-like/multiple giant cell lesion (NS/MGCL) is a rare condition overlapping with Noonan syndrome. Once thought to be a specific and separate entity, it is now suggested to be a variant of the Noonan syndrome spectrum. We report the case of an 8-year-old boy with a typical clinical picture of Noonan syndrome with a de novo germline mutation of PTPN11 (c. Read More