30,470 results match your criteria Pigmented Purpuric Dermatitis


Megakaryocytic leukemia 1 (MKL1) mediates high glucose induced epithelial-mesenchymal transition by activating LOX transcription.

Biochem Biophys Res Commun 2018 Dec 13. Epub 2018 Dec 13.

Key Laboratory of Targeted Intervention of Cardiovascular Disease and Collaborative Innovation Center for Cardiovascular Translational Medicine, Department of Pathophysiology, Nanjing Medical University, Nanjing, China; Institute of Biomedical Research, Liaocheng University, Liaocheng, China. Electronic address:

Diabetic retinopathy (DR) is one of the most devastating complications of diabetes mellitus. When exposed to high glucose (HG), retinal epithelial cells undergo profound alterations both morphologically and functionally in a well-conserved process known as epithelial-to-mesenchymal transition (EMT). The mechanism governing HG-induced EMT in retinal epithelial cells is not completely understood. Read More

View Article
December 2018

Immune cells in the retina and choroid: Two different tissue environments that require different defenses and surveillance.

Prog Retin Eye Res 2018 Dec 12. Epub 2018 Dec 12.

Department of Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.

In the eye immune defenses must take place in a plethora of differing microenvironments ranging from the corneal and conjunctival epithelia facing the external environment to the pigmented connective tissue of the uveal tract containing smooth muscle, blood vessels and peripheral nerves to the innermost and highly protected neural retina. The extravascular environment of the neural retina, like the brain parenchyma, is stringently controlled to maintain conditions required for neural transmission. The unique physiological nature of the neural retina can be attributed to the blood retinal barriers (BRB) of the retinal vasculature and the retinal pigment epithelium, which both tightly regulate the transport of small molecules and restrict passage of cells and macromolecules from the circulation into the retina in a similar fashion to the blood brain barrier (BBB). Read More

View Article
December 2018

Renaming of 'Candidatus Methylocucumis oryzae' as Methylocucumis oryzae gen. nov., sp. nov., a novel Type I methanotroph isolated from India.

Antonie Van Leeuwenhoek 2018 Dec 15. Epub 2018 Dec 15.

MACS Agharkar Research Institute, G.G. Agarkar Road, Pune, 411004, Maharashtra, India.

Candidatus Methylocucumis (Mcu.) oryzae, strain Sn10-6, a Gram-negative, pale pink pigmented, motile, large Type I methanotroph (3-6 µm × 1.5-2 µm) was recently isolated from an Indian rice field. Read More

View Article
December 2018

[Analysis of distant metastasis and related factors of head and neck mucosal melanoma].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Jul;32(14):1078-1081

Department of Otorhinolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, 100010, China.

To analyze the characteristics and related factors of distant metastasis of head and neck mucosal melanoma, so as to provide better help for the treatment and the control of patients' survival. Retrospectively analyze the patients of head and neck mucosal melanoma who were treated in our hospital from January 2004 to December 2016, through follow-up, of which 37 cases of patients with metastatic disease were analyzed which including the incidence of distant metastasis, specific metastasis and prognosis, time, etc.The age and gender of the patients were controlled, and 37 cases of 1∶1 were selected randomly in the patients who had no distant metastasis. Read More

View Article

Histopathologic correlation of high-risk MelaFind lesions: a 3-year experience from a high-risk pigmented lesion clinic.

Int J Dermatol 2018 Dec 13. Epub 2018 Dec 13.

Dermatology and Plastic Surgery Institute, Cleveland Clinic, Cleveland, OH, USA.

Background: A significant number of pigmented lesions are biopsied to rule out melanoma, but most will be benign. MelaFind is a highly sensitive, noninvasive computer-assisted system to aid in clinical diagnosis of melanoma.

Methods: A total of 140 high-risk patients were followed by one expert dermatologist. Read More

View Article
December 2018
1 Read

Visible light accelerates the ultraviolet A-induced degradation of eumelanin and pheomelanin.

Pigment Cell Melanoma Res 2018 Nov 22. Epub 2018 Nov 22.

Department of Chemistry, Fujita Health University School of Health Sciences, Toyoake, Japan.

Exposure to excess ultraviolet (UV) A radiation induces the degradation/modification of both eumelanin and pheomelanin that may be deleterious to pigmented tissues. Although the spectral distribution of solar energy comprises nearly half of visible light (VL), few studies have been conducted to examine the role of VL in the photodegradation of both types of melanin, either VL alone or in combination with UVA. In this study, we examined the effects of physiological doses of VL (150 to 300 J cm ) alone or in combination with a physiological dose of UVA (20 J cm ) in normal human epidermal melanocytes. Read More

View Article
November 2018

General hyperpigmentation induced by Grave's disease: A case report.

Medicine (Baltimore) 2018 Dec;97(49):e13279

Department of Endocrinology, The Second Affiliated Hospital of Zhejiang University School of Medicine.

Rationale: Hyperpigmentation is a common skin disease. However, there are few reported cases of Grave's disease with diffuse hyperpigmentation. We hereby described a rare case with diffuse hyperpigmentation induced by Grave's disease. Read More

View Article
December 2018

Malignant Melanomas of the Skin Arising on the Feet.

Klin Onkol 2018 ;31(4):289-292

Background: Cutaneous melanoma frequently develops on the lower limbs, but rarely on the feet, in people with light skin. By contrast, the feet are one of the most frequently affected sites in people with dark skin. This study assessed the prevalence and clinico-pathological findings of biopsy-proven skin melanomas that were diagnosed over 11 years. Read More

View Article
January 2018

[Pigmented microcystic chromophobe renal cell carcinoma: a clinicopathologic analysis of five cases].

Zhonghua Bing Li Xue Za Zhi 2018 Dec;47(12):926-930

Department of Pathology, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou 310014, China.

To investigate the clinicopathologic features, diagnostic and differential diagnostic aspects of pigmented microcystic chromophobe renal cell carcinoma (ChRCC). Five cases of pigmented microcystic ChRCC were collected at Zhejiang Provincial People's Hospital from January 2013 to January 2018. The clinical features, gross and histological appearances, immunohistochemistry and prognosis were analyzed and the relevant literature was reviewed. Read More

View Article
December 2018

Annular Pigmented Plaque Under the Chin.

Actas Dermosifiliogr 2018 Dec 30;109(10):911-912. Epub 2018 Jun 30.

Unidad de Dermatología Médico-Quirúrgica y Venereología, Complejo Hospitalario Universitario de Granada, Granada, España.

View Article
December 2018

The effects of radiosynoviorthesis in pigmented villonodular synovitis of the knee.

Arch Orthop Trauma Surg 2018 Dec 11. Epub 2018 Dec 11.

Department of Nuclear Medicine, University Hospital, LMU Munich, Munich, Germany.

Introduction: Tenosynovial giant-cell tumor also known as pigmented villonodular synovitis (PVS) is a benign but aggressive synovial proliferative disease most often affecting the knee joint. The mainstay of therapy is surgical resection. Due to a high rate of local recurrence, radiosynoviorthesis (RSO) is used as an adjuvant method in many cases. Read More

View Article
December 2018

Targeted radiotherapy of pigmented melanoma with I-5-IPN.

J Exp Clin Cancer Res 2018 Dec 11;37(1):306. Epub 2018 Dec 11.

Department of Nuclear Medicine, Wuhan Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277 Jiefang Ave, Wuhan, 430022, Hubei Province, China.

Purpose: There has been no satisfactory treatment for advanced melanoma until now. Targeted radionuclide therapy (TRNT) may be a promising option for this heretofore lethal disease. Our goal in this study was to synthesize I-N-(2-(diethylamino)ethyl)-5-(iodo-131I)picolinamide (I-5-IPN) and evaluate its therapeutic ability and toxicity as a radioiodinated melanin-targeting therapeutic agent. Read More

View Article
December 2018

Photoinactivation of uncultured, indigenous enterococci.

Environ Sci Process Impacts 2018 Dec 7. Epub 2018 Dec 7.

Civil & Environmental Engineering, Stanford University, Stanford, CA, USA.

Enterococci are used to monitor recreational water quality worldwide, so understanding their fate and transport in the environment is essential to the protection of human health. As such, researchers have documented enterococci inactivation under various exposure conditions and in diverse water matrices. However, the majority of studies have been performed using lab-cultured bacteria, which are distinct from indigenous, uncultured bacteria found in the environment. Read More

View Article
December 2018

Immunotoxic effects of 4-nonylphenol on Clarias gariepinus: Cytopathological changes in hepatic melanomacrophages.

Aquat Toxicol 2018 Dec 3;207:83-90. Epub 2018 Dec 3.

Medical Physiology Department, Faculty of Medicine, Assiut University, Assiut, Egypt.

Melanomacrophage centres (MMCs) play a key role in the immune response in fish. They are considered sensitive bio-monitoring structures with roles in the assessment of toxicant impacts. The aim of this study was to examine the potential histopathological effect of 4-nonylphenol (4-NP) on hepatic MMCs in Clarias gariepinus. Read More

View Article
December 2018
1 Read

Molecular and cellular basis of depigmentation in vitiligo patients.

Exp Dermatol 2018 Dec 10. Epub 2018 Dec 10.

Institut Curie, PSL Research University, INSERM U1021, Normal and Pathological Development of Melanocytes, Orsay, France.

Vitiligo is a chronic skin disease characterized by the appearance of zones of depigmentation. It is mostly described as an autoimmune disease in which the immune system destroys the melanocytes. Consistent with this origin, genetic studies have implicated genes encoding proteins mediating the immune response targeting melanocytes in the etiology of this disease, together with proteins specific to these cells. Read More

View Article
December 2018
1 Read

Prenatal development of retina in buffalo (Bubalus bubalis).

Anat Histol Embryol 2018 Dec 10. Epub 2018 Dec 10.

Department of Veterinary Anatomy, Guru Angad Dev Veterinary & Animal Sciences University, Ludhiana, India.

The development of retina in Indian buffalo (Bubalus bubalis) has not been reported previously. The aim of the present study was therefore to report the major landmarks and the time course in the development of retina. Serial histological sections of Indian buffalo embryos and foetuses were used as group1 (<20. Read More

View Article
December 2018
3 Reads

High-resolution, in vivo multimodal photoacoustic microscopy, optical coherence tomography, and fluorescence microscopy imaging of rabbit retinal neovascularization.

Light Sci Appl 2018 5;7:103. Epub 2018 Dec 5.

1Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48105 USA.

Photoacoustic microscopy (PAM) is an emerging imaging technology that can non-invasively visualize ocular structures in animal eyes. This report describes an integrated multimodality imaging system that combines PAM, optical coherence tomography (OCT), and fluorescence microscopy (FM) to evaluate angiogenesis in larger animal eyes. High-resolution in vivo imaging was performed in live rabbit eyes with vascular endothelial growth factor (VEGF)-induced retinal neovascularization (RNV). Read More

View Article
December 2018
4 Reads
8.476 Impact Factor

Draft Genome Sequence of " Spirobacillus cienkowskii," a Pathogen of Freshwater Species, Reconstructed from Hemolymph Metagenomic Reads.

Microbiol Resour Announc 2018 Dec 6;7(22). Epub 2018 Dec 6.

Department of Land, Air, and Water Resources, University of California, Davis, California, USA.

We report here the near-complete genome sequence of " Spirobacillus cienkowskii," a spiral-shaped, red-pigmented uncultivated bacterial pathogen of spp. The genome is 2.74 Mbp in size, has a GC content of 32. Read More

View Article
December 2018

[Discrasia linfoide epiteliotrópica de células T. Tratamiento con radiación ultravioleta].

Gac Med Mex 2018 ;154(Supp 2):S41-S49

Unidad de Fototerapia. Hospital General Dr. Manuel Gea González, Ciudad de México, México.

Introduction: T-cell lymphoid dyscrasia is a group of different, infrequent, epitheliotropic inflammatory dermatosis that precede cutaneous T-cell lymphomas. Treatment with ultraviolet radiation is safe and efficacious.

Objective: To describe responses to treatment, secondary effects and complications. Read More

View Article
January 2018

Acquired diffuse slate-grey facial dyspigmentation due to henna: an unrecognized cause of pigment contact dermatitis in Korean patients.

Eur J Dermatol 2018 Oct;28(5):644-648

Department of Dermatology, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Henna is a vegetable hair dye that can be used by individuals who are sensitized to oxidative dyes due to low allergenicity. The reported incidence of slate-grey facial dyspigmentation following the use of henna hair dye is extremely rare. This study aimed to identify the clinical, dermoscopic, and histopathological features of slate-grey facial dyspigmentation following the use of henna hair dye in Korean patients. Read More

View Article
October 2018
4 Reads

Innocuous "foot lump" in patient with diabetes mellitus: A manifestation of phaeohyphomycosis.

Foot (Edinb) 2018 Nov 28;38:4-7. Epub 2018 Nov 28.

Department of Endocrinology, PGIMER, Chandigarh, 160012, IndiaIndia.

Invasive mycotic infection presenting as "foot lump" in an immunocompetent patient is extremely rare. The case highlights the difficulty in diagnosis of fungal infections of foot including attempts to isolate the fungus and non-response to anti-fungal agents. A 64-year-old lady with T2DM for four years presented with painless, gradually progressive swelling over plantar aspect of left mid-foot for six months. Read More

View Article
November 2018

Visual inspection and dermoscopy, alone or in combination, for diagnosing keratinocyte skin cancers in adults.

Cochrane Database Syst Rev 2018 Dec 3;12:CD011901. Epub 2018 Dec 3.

Institute of Applied Health Research, University of Birmingham, Birmingham, UK, B15 2TT.

Background: Early accurate detection of all skin cancer types is important to guide appropriate management, to reduce morbidity and to improve survival. Basal cell carcinoma (BCC) is almost always a localised skin cancer with potential to infiltrate and damage surrounding tissue, whereas a minority of cutaneous squamous cell carcinomas (cSCCs) and invasive melanomas are higher-risk skin cancers with the potential to metastasise and cause death. Dermoscopy has become an important tool to assist specialist clinicians in the diagnosis of melanoma, and is increasingly used in primary-care settings. Read More

View Article
December 2018
5 Reads

Opposing Effects of PPARα Agonism and Antagonism on Refractive Development and Form Deprivation Myopia in Guinea Pigs.

Invest Ophthalmol Vis Sci 2018 Dec;59(15):5803-5815

School of Ophthalmology and Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China.

Purpose: To determine if drug-induced peroxisome proliferator-activated receptor α (PPARα) signal pathway modulation affects refractive development and myopia in guinea pigs.

Methods: Pigmented guinea pigs were randomly divided into normal vision (unoccluded) and form deprivation myopia (FDM) groups. Each group received daily peribulbar injections of either a vehicle or (1) PPARα agonist, GW7647, clofibrate, or bezafibrate or (2) PPARα antagonist, GW6471, for 4 weeks. Read More

View Article
December 2018
1 Read

Winogradskyella algae sp. nov., a marine bacterium isolated from the brown alga.

Antonie Van Leeuwenhoek 2018 Dec 5. Epub 2018 Dec 5.

G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch, Russian Academy of Sciences, Prospect 100 Let Vladivostoku, 159, Vladivostok, Russia, 690022.

An aerobic, Gram-negative, yellow-pigmented non-motile rod-shaped bacterium Kr9-9 was isolated from a brown alga specimen collected near the Kuril Islands. Based on the 16S rRNA gene sequence analysis strain Kr9-9 was assigned to the genus Winogradskyella, and its close phylogenetic neighbors were found to be Winogradskyella damuponensis KCTC 23552, Winogradskyella sediminis LMG 28075, and Winogradskyella rapida CCUG 59098 showing high similarities of 98.1%, 97. Read More

View Article
December 2018
5 Reads

Rock substrate rather than black stain alterations drives microbial community structure in the passage of Lascaux Cave.

Microbiome 2018 Dec 5;6(1):216. Epub 2018 Dec 5.

Univ Lyon, Université Claude Bernard Lyon 1, CNRS, INRA, VetAgro Sup, UMR5557/1418 Ecologie Microbienne, 69622, Villeurbanne, France.

Background: The World-famous UNESCO heritage from the Paleolithic human society, Lascaux Cave (France), has endeavored intense microclimatic perturbations, in part due to high touristic pressure. These perturbations have resulted in numerous disturbances of the cave ecosystem, including on its microbial compartment, which resulted in the formation of black stains especially on the rock faces of the passage. We investigated the cave microbiome in this part of Lascaux by sampling three mineral substrates (soil, banks, and inclined planes) on and outside stains to assess current cave microbial assemblage and explore the possibility that pigmented microorganisms involved in stain development occur as microbial consortia. Read More

View Article
December 2018
1 Read

Development of a Pigmented Facial Lesion Scale based on darkness and extent of lesions in older veterans.

J Invest Dermatol 2018 Nov 30. Epub 2018 Nov 30.

Center for Dermatoepidemiology, Veterans Affairs Medical Center, Providence, Rhode Island, USA; Department of Dermatology, Alpert Medical School of Brown University, Providence, Rhode Island, USA.

View Article
November 2018

An unusually pigmented colon.

Lancet Gastroenterol Hepatol 2018 Dec;3(12):884

University Hospital Coventry and Warwickshire, Clifford Bridge Road, Coventry, CV2 2DX, UK.

View Article
December 2018
1 Read

Pigmented skin lesions displaying regression features: dermoscopy and reflectance confocal microscopy criteria for diagnosis.

Exp Dermatol 2018 Dec 2. Epub 2018 Dec 2.

Centro Oncologico ad Alta Tecnologia Diagnostica, Azienda Unità Sanitaria Locale - IRCCS, Reggio Emilia, Italy.

Melanomas and nevi displaying regression features can be difficult to differentiate. To describe reflectance confocal microscopy features in benign and malignant pigmented skin lesions characterized by regression features in dermoscopy. Methods: Observational retrospective study. Read More

View Article
December 2018
4 Reads

Acral and Multicentric Pigmented Bowen's Disease in HIV-Positive Patients: Report on Two Unusual Cases.

Indian J Dermatol 2018 Nov-Dec;63(6):506-508

Centro De Investigación En Enfermedades Infecciosas, Instituto Nacional De Enfermedades Respiratorias, Ismael Cosío Villegas, México City, México.

squamous cell carcinoma of the skin (SCCis or Bowen's disease) is a common intraepidermal cutaneous malignancy with a low invasive potential. Acral Bowen's disease is usually solitary, but multiple acral SCCis have been reported. Pigmented Bowen's disease is typically unilesional and characterized by a hyperpigmented plaque with a velvety of keratotic surface, which can eventually simulate melanoma clinically. Read More

View Article
December 2018
1 Read

Spatio-temporal regulation of Rx and mitotic patterns shape the eye-cup of the photoreceptor cells in Ciona.

Dev Biol 2018 Nov 28. Epub 2018 Nov 28.

Institute for Integrative Neurobiology and Department of Biology, Faculty of Science and Engineering, Konan University, Kobe 658-8501, Japan. Electronic address:

The ascidian larva has a pigmented ocellus comprised of a cup-shaped array of approximately 30 photoreceptor cells, a pigment cell, and three lens cells. Morphological, physiological and molecular evidence has suggested evolutionary kinship between the ascidian larval photoreceptors and vertebrate retinal and/or pineal photoreceptors. Rx, an essential factor for vertebrate photoreceptor development, has also been suggested to be involved in the development of the ascidian photoreceptor cells, but a recent revision of the photoreceptor cell lineage raised a crucial discrepancy between the reported expression patterns of Rx and the cell lineage. Read More

View Article
November 2018

Bioactive compounds in rice on Italian market: pigmented varieties as a source of carotenoids, total phenolic compounds and anthocyanins, before and after cooking.

Food Chem 2019 Mar 11;277:119-127. Epub 2018 Oct 11.

CREA Research Centre for Food and Nutrition, Via Ardeatina 546, I-00178 Rome, Italy.

The aim of this study was to fully characterize the main pigmented rice varieties, available to consumers on the Italian market, in terms of carotenoids, total phenolic compounds and anthocyanins, and to investigate the effect of cooking on these components. Lutein was the main carotenoid in all samples under investigation (0.33-4. Read More

View Article

A Deep Learning Approach to Vascular Structure Segmentation in Dermoscopy Colour Images.

Biomed Res Int 2018 1;2018:5049390. Epub 2018 Nov 1.

Department of Automatic Control and Robotics, AGH University of Science and Technology, Cracow, Poland.

Background: Atypical vascular pattern is one of the most important features by differentiating between benign and malignant pigmented skin lesions. Detection and analysis of vascular structures is a necessary initial step for skin mole assessment; it is a prerequisite step to provide an accurate outcome for the widely used 7-point checklist diagnostic algorithm.

Methods: In this research we present a fully automated machine learning approach for segmenting vascular structures in dermoscopy colour images. Read More

View Article
November 2018
10 Reads

[miR-122-5p inhibits the proliferation of melanoma cells by targeting NOP14].

Nan Fang Yi Ke Da Xue Xue Bao 2018 Nov;38(11):1360-1365

Department of Dermatology, Guangzhou Institute of Dermatology, Guangzhou 510095, China.

Objective: To investigate the expression profile of miR-122-5p in melanoma tissues and the effect of miR-122-5p on the proliferation, cell cycle and apoptosis of human melanoma cell lines SK-MEL-110 and A375.

Methods: The expression profiles of miR-122-5p in melanoma and pigmented nevus tissues were detected using real-time fluorescence quantitative PCR (qRT-PCR). SK-MEL-110 and A375 cells transfected with miR-122-5p inhibitor or negative control inhibitor (NC) I were examined for miR-122- 5p expression using qRT-PCR and changes in cell proliferation, cell cycle and apoptosis using MTT assay or flow cytometry. Read More

View Article
November 2018
5 Reads

MicroRNA-29 enhances autophagy and cleanses exogenous mutant αB-crystallin in retinal pigment epithelial cells.

Exp Cell Res 2019 Jan 1;374(1):231-248. Epub 2018 Dec 1.

School of Optometry and Ophthalmology and the Eye Hospital, Wenzhou Medical University, PR China; State Key Laboratory of Optometry, Ophthalmology, and Visual Science, Wenzhou, Zhejiang, 325027, PR China. Electronic address:

Retinal pigment epithelial cells (RPEs), a pigmented cell layer in the outer retina, are constantly exposed to photo-oxidative stress. Autophagy relieves the stress by removing oxidative protein adducts, protein aggregates, and damaged mitochondria. We previously found that miR-29 is downregulated in choroid/RPE tissue in a model of exudative age-related macular degeneration (AMD), suggesting that miR-29 deficiency may contribute to autophagy inhibition and AMD progression. Read More

View Article
January 2019
3 Reads

Pigmented lesion in the anterior chamber angle following multiple trans-scleral diode laser photocoagulation for congenital glaucoma.

Am J Ophthalmol Case Rep 2019 Mar 14;13:32-33. Epub 2018 Nov 14.

King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia.

Purpose: To describe a child with primary congenital glaucoma found to have pigment tissue proliferation in the angle following multiple applications of trans-scleral cyclophotocoagulation.

Observations: During examination under anaesthesia, a 4-year-old girl was found to have pigmented tissue overlying the trabecular meshwork. Anterior segment ocular coherence tomography confirmed mounds of abnormal tissue in the angle. Read More

View Article

Carney complex: Two case reports and review of literature.

World J Clin Cases 2018 Nov;6(14):800-806

Department of Radiology, Peking Union Medical College Hospital, Beijing 100730, China.

Carney complex (CNC) is an extremely rare genetic syndrome of pigmented skin lesions, endocrine hyperfunction and myxoma. Given its diverse clinical manifestations, CNC is often misdiagnosed. Recognition of some special clinical manifestations and imaging features may help with the diagnosis. Read More

View Article
November 2018
4 Reads

UVB-induced depletion of donor-derived dendritic cells prevents allograft rejection of immune-privileged hair follicles in humanized mice.

Am J Transplant 2018 Nov 30. Epub 2018 Nov 30.

Department of Dermatology, Seoul National University College of Medicine, Seoul, Korea.

Dendritic cells (DCs) are key targets for immunity and tolerance induction; they present donor antigens to recipient T cells by donor- and recipient-derived pathways. Donor-derived DCs, which are critical during the acute posttransplantation period, can be depleted in graft tissue by forced migration via UVB irradiation. Here, we investigated the tolerogenic potential of donor-derived DC depletion through in vivo and ex vivo UVB preirradiation (UV) combined with injection of anti-CD154 Ab into recipients in an MHC-mismatched hair follicle (HF) allograft model in humanized mice. Read More

View Article
November 2018
1 Read

Non-Invasive Analysis of High-Risk Driver Mutations and Gene Expression Profiles in Primary Cutaneous Melanoma.

J Invest Dermatol 2018 Nov 27. Epub 2018 Nov 27.

Cockerell Dermatopathology, Dallas, TX.

Tools that help reduce the number of surgical biopsies performed on benign lesions have the potential to improve patient care. The pigmented lesion assay (PLA) is a non-invasive tool validated against histopathology that helps rule out melanoma and the need for surgical biopsies of atypical pigmented skin lesions. Genetic information is collected using adhesive patches and the expression of two genes, LINC00518 and PRAME, is measured. Read More

View Article
November 2018
5 Reads

Malignant melanoma of conjunctiva: Diagnosis on fine-needle aspiration cytology.

J Lab Physicians 2018 Oct-Dec;10(4):453-456

Department of Pathology, Post Graduate Institute of Medical Education and Research, Dr. Ram Manohar Lohia Hospital, New Delhi, India.

Malignant melanoma of conjunctiva is an uncommon malignancy. The diagnosis is suspected clinically and confirmed on pathological examination. We present a case of a 63-year-old female with previous history of pigmented lesion in the right eye and subsequently diagnosed as malignant melanoma of right conjunctiva and cornea on fine-needle aspiration cytology and histopathology. Read More

View Article
December 2018

Pigmented villonodular synovitis occurring in the temporomandibular joint.

Auris Nasus Larynx 2018 Nov 26. Epub 2018 Nov 26.

Department of Head and Neck Surgry, Tokyo Medical and Dental University, Japan.

Objective: Pigmented villonodular synovitis occurring in the region of the temporomandibular joint is a rare disease, requiring a review of the treatment method, follow-up period.

Method: Refer to the past literature, along with a retrospective search.

Results: An excision, including the skull base bone, was performed in all cases; however, recurrence was found in one case on which fractional excision was performed. Read More

View Article
November 2018
2 Reads

Pigmented pruritic macules in the genital area.

Cutis 2018 Oct;102(4):E21-E22

Division of Dermatology, Ohio State University Department of Internal Medicine, Columbus, Ohio, USA.

View Article
October 2018
1 Read

New record of Hydrozoa Distichopora violacea (Pallas, 1766) (Anthoathecata: Stylasteridae) from Andaman and Nicobar Islands, India.

Zootaxa 2018 Oct 31;4508(3):439-442. Epub 2018 Oct 31.

Zoological Survey of India, Andaman Nicobar Regional Centre, Port Blair-744102, Andaman and Nicobar Islands, India..

The class Hydrozoa consists of mostly marine and few freshwater organisms classified into 7 orders amongst which the order Anthoathecata consists of 48 families with approximately 1,140 valid species (Cartwright Collins 2007). Stylasteridae is one among the families that comprises the order Anthoathecata, and is characterized by a calcareous exoskeleton which is often brightly pigmented. The members of the family are commonly called lace corals. Read More

View Article
October 2018
0.906 Impact Factor

Mechanism of miR-137 regulating migration and invasion of melanoma cells by targeting PIK3R3 gene.

J Cell Biochem 2018 Nov 28. Epub 2018 Nov 28.

Department of Laboratory Medicine, Tongji hospital of Tongji University, Shanghai, China.

Objective: To investigate the effect of microRNA-137 (miR-137) on the migration and invasion of melanoma cells and its mechanism.

Methods: Quantitative real-time polymerase chain reaction (qRT-PCR) was used to detect the expression of miR-137 in melanoma tissues and cells. miR-137 mimics, phosphoinositide-3-kinase regulatory subunit 3 (PIK3R3) small interfering RNA and corresponding controls were transfected into A375 and WM451 cells by lipofection. Read More

View Article
November 2018
1 Read

Expert-Level Diagnosis of Nonpigmented Skin Cancer by Combined Convolutional Neural Networks.

JAMA Dermatol 2018 Nov 28. Epub 2018 Nov 28.

Vienna Dermatologic Imaging Research Group, Department of Dermatology, Medical University of Vienna, Vienna, Austria.

Importance: Convolutional neural networks (CNNs) achieve expert-level accuracy in the diagnosis of pigmented melanocytic lesions. However, the most common types of skin cancer are nonpigmented and nonmelanocytic, and are more difficult to diagnose.

Objective: To compare the accuracy of a CNN-based classifier with that of physicians with different levels of experience. Read More

View Article
November 2018
5 Reads

Assessing the efficacy of a 10-point referral tool in the triaging of pigmented lesions to a Dermatology clinic.

An Bras Dermatol 2018 Nov/Dec;93(6):932-933

Department of Dermatology, NHS Lothian, Edinburgh, United Kingdom.

View Article
January 2018

Descriptive dermoscopy terminology in Portuguese language in Brazil: a reproducibility analysis of the 3rd consensus of the International Dermoscopy Society.

An Bras Dermatol 2018 Nov/Dec;93(6):852-858

Pigmented Lesions Outpatient Clinic, Dermoscopy and Confocal Microscopy, Hospital Universitário Pedro Ernesto, Universidade do Estado do Rio de Janeiro, Rio de Janeiro (RJ), Brazil.

Background: Dermoscopy is a noninvasive complementary diagnostic method largely used in dermatology. Feasibility, accuracy, and reproducibility are key elements for a diagnostic method to be useful, hence the importance of the terminology used to describe dermoscopic criteria.

Objective: To evaluate the reproducibility of the English descriptive terminology proposed for dermoscopic criteria at the 3rd Consensus Meeting of the International Dermoscopy Society in Brazilian Portuguese. Read More

View Article
October 2017

Evaluation of skin expression profiles of patients with vitiligo treated with narrow-band UVB therapy by targeted RNA-seq.

An Bras Dermatol 2018 Nov/Dec;93(6):843-851

Department of Biochemistry and Molecular Medicine, Facultad de Medicina, Universidad Autónoma de Nuevo León, Nuevo León, México.

Background: Vitiligo is characterized by a lack of pigmentation in the skin. To date, there are no studies that analyze the changes in gene expression in the skin of vitiligo patients in response to narrow-band ultraviolet B (nb-UVB) phototherapy treatment.

Objective: Explore the usefulness of new generation RNA sequencing in the identification of gene expression changes in the skin of vitiligo patients treated with nb-UVB phototherapy. Read More

View Article
August 2017
2 Reads

Artificial Pigmented Human Skin Created by Muse Cells.

Adv Exp Med Biol 2018 ;1103:255-271

Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan.

The skin composes physiological and chemical barrier and renews skin component cells throughout the human life. Melanocytes locate in the basal layer of the epidermis and produce melanin to protect the skin from ultraviolet. Melanin plays key roles in determining human skin and hair color. Read More

View Article
January 2018

Breast Cancer Metastasis in the Skin with Hyperkeratotic Pigmentation Caused by Melanocyte Colonization.

Case Rep Oncol 2018 Sep-Dec;11(3):660-664. Epub 2018 Oct 23.

Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan.

Pigmented breast cancer in the skin caused by nonneoplastic melanocytes of epidermal origin is a rare condition of metastasis from breast cancer, but the pathogenesis of this phenomenon is almost unknown. In this report, we describe a case of breast cancer metastasis in the skin with prominent hyperkeratotic pigmentation caused by nonneoplastic melanocyte colonization. Immunohistochemical staining revealed that the metastatic tumor cells produced IL-23, which is reported not only to induce IL-17 but also to inhibit cell apoptosis in breast cancer cells, which affects tumor progression. Read More

View Article
October 2018
3 Reads