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J Cutan Pathol 2022 Jul 22;49(7):597-603. Epub 2022 Mar 22.

Kempf und Pfaltz Histologische Diagnostik, Zurich, Switzerland.

We report the largest case series to date of granulomatous pigmented purpuric dermatosis (GPPD), a rare variant of pigmented purpuric dermatoses (PPD). GPPD can cause diagnostic difficulties as it can be mistaken clinically and histopathologically with numerous inflammatory and infectious dermatoses or even cutaneous T-cell lymphoma. We compared the histopathological findings of nine cases of GPPD with a control group consisting of 10 randomly selected PPD of other subtypes. Read More

J Clin Med 2021 May 25;10(11). Epub 2021 May 25.

Dermatology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy.

Pigmented purpuric dermatoses (PPD) include several skin diseases characterized by multiple petechial hemorrhage as consequence of capillaritis. PPD generally present with red to purple macules that progressively evolve to golden-brown color as the hemosiderin is reabsorbed. These lesions, often asymptomatic or associated with mild pruritus, usually occur on the lower extremities and may be a diagnostic and therapeutic challenge both for general practitioners and specialists in internal medicine or flebology. Read More

J Cutan Pathol 2021 08 3;48(8):1101-1102. Epub 2021 Jun 3.

Pathology, Institute of Araçatuba, Araçatuba, São Paulo, Brazil.

Pediatr Dermatol 2021 Mar 5;38(2):506-507. Epub 2021 Feb 5.

Division of Dermatopathology, Department of Dermatology, UConn Health, Farmington, CT, USA.

Granulomatous pigmented purpuric dermatoses (PPD) are rarely reported. We present a case of granulomatous PPD in a 7-year-old boy, one of only two pediatric cases with reported solitary disease. The pathogenesis of unilesional granulomatous PPD may be different from the more commonly described multifocal/widespread disease variant. Read More

Pediatr Dermatol 2021 Mar 6;38(2):504-505. Epub 2021 Jan 6.

Department of Dermatology, Hospital Infantil Niño Jesús, Madrid, Spain.

Pigmented purpuric dermatoses (PPDs) are a group of idiopathic, chronic, and self-resolving conditions easily recognizable in adults but extremely uncommon in infants. We present the youngest patient with PPD reported to date. Read More

Dermatol Pract Concept 2020 Oct 26;10(4):e2020075. Epub 2020 Oct 26.

Dermatology Department, Centro Hospitalar Universitário Lisboa Norte, EPE (CHULN), Lisbon, Portugal.

Dermatol Ther 2020 03 20;33(2):e13265. Epub 2020 Feb 20.

Department of Dermatovenerology, Tianjin Medical University General Hospital, Tianjin, China.

Lichen aureus is a particularly rare subtype of pigmented purpuric dermatosis and is characterized by the sudden appearance of golden or rust-colored macules or needle-tip-sized flat papules (concentrated in one region to form lichenoid papules) on the lower limbs. These skin lesions are usually confined to an isolated, unilateral distribution, and linear segmental distribution is rare. In this report, we have documented one such case, where the lesions on the limb were arranged in strips (segmental distribution) that roughly followed the direction of the venous drainage. Read More

Actas Dermosifiliogr (Engl Ed) 2020 Apr 23;111(3):196-204. Epub 2020 Jan 23.

Servicio de Dermatología y Venereología, Hospital Clínico Lozano Blesa, Zaragoza, España.

The pigmented purpuric dermatoses are a group of benign, chronic diseases. The variants described to date represent different clinical presentations of the same entity, all having similar histopathologic characteristics. We provide an overview of the most common PPDs and describe their clinical, dermatopathologic, and epiluminescence features. Read More

Ital J Dermatol Venerol 2021 Dec 18;156(Suppl. 1 to No. 6):74-75. Epub 2019 Nov 18.

Department of Dermatology and Venereology, Umberto I Polyclinic Hospital, Sapienza University, Rome, Italy.

J Am Acad Dermatol 2019 Nov 1;81(5):1157-1164. Epub 2019 Aug 1.

Department of Dermatology, University of Florida College of Medicine, Gainesville, Florida. Electronic address:

Background: Lichenoid granulomatous dermatitis (LGD) is an uncommon reaction pattern for which clinical correlates can be difficult to establish. LGD combines vacuolar degeneration with variable types of granulomas.

Objective: To determine clinical correlates of LGD. Read More

Cutan Ocul Toxicol 2019 Sep 25;38(3):258-260. Epub 2019 Mar 25.

a Department of Dermatology, Kocaeli University School of Medicine , Kocaeli , Turkey.

The aetiology of pigmented purpuric dermatoses is unclear. Recent studies speculate about contact sensitivity to play a role in the aetiology of the disease. In most patients, the lesions begin and stay limited on the lower extremities as textile products are in tight contact with the skin. Read More

Skinmed 2018;16(1):13-17. Epub 2018 Feb 1.

Section on Dermatology, University of Chicago Pritzker School of Medicine, Chicago, IL.

We describe two cases of cutaneous eruptions of pigmented purpuric dermatoses (PPDs) arising after exposure to medications not previously reported in the literature as causing these reactions. Specifically, two women had biopsy-proven PPDs, one after exposure to an over-the-counter iodine supplement marketed as an extract from "Norwegian kelp," and the other after intraocular injections of pegaptanib, a vascular endothelial growth factor inhibitor. The eruption occurred shortly after beginning the medication and resolved upon discontinuation. Read More

Case Rep Dermatol 2017 Sep-Dec;9(3):169-176. Epub 2017 Sep 15.

Department of Dermatology, Aarhus University Hospital, Aarhus, Denmark.

We report the case of a 12-year-old girl who presented a rash with reddish-brown patches on the trunk and extremities indicative of pigmented purpuric lichenoid dermatitis of Gougerot-Blum (PPLD). The histological findings were characteristic for PPLD, thus supporting the diagnosis. Topically administered corticosteroid led to a fast resolution of all symptoms. Read More

Ann Hematol 2017 Jul 8;96(7):1209-1210. Epub 2017 Apr 8.

Department of Dermatology, Hospital Universitario Infanta Cristina, Parla, Madrid, Spain.

Arch Argent Pediatr 2017 04;115(2):e82-e84

Servicio de Dermatología, Hospital Clínico Universitario Lozano Blesa, Zaragoza, España.

Lichen aureus is a rare pigmented purpuric dermatosis. We present an unusual case because of the pediatric age and the great number of lesions with zosteriform distribution. He is a 10-yearold boy, with a brownish, smaller than 1 cm, sharp edges, lichenified surface, asymptomatic macule, over the inner aspect of the left leg with a zosteriform distribution. Read More

Am J Clin Dermatol 2017 Jun;18(3):383-390

Department of Dermatology, University of Texas McGovern Medical School at Houston, 6655 Travis St, Ste 980, Houston, TX, 77030, USA.

Stasis dermatitis commonly occurs in older age. It is caused by venous hypertension resulting from retrograde flow due to incompetent venous valves, valve destruction, or obstruction of the venous system. Further tissue changes arise from an inflammatory process mediated by metalloproteinases, which are up-regulated by ferric ion from extravasated red blood cells. Read More

J Dermatol 2017 May 3;44(5):533-537. Epub 2016 Dec 3.

Department of Dermatology, Kosin University College of Medicine, Busan, Korea.

Lichen aureus (LA) is a variant of pigmented purpuric dermatosis that is characterized clinically by rust macules, papules or plaques, mainly on the legs. In some cases, LA can be difficult to be distinguished from nummular eczema (NE) with the naked eye. Dermoscopy can be applied to skin lesions, revealing additional features that can be highly valuable for correct diagnosis. Read More

Eur J Dermatol 2016 Jun;26(3):290-4

Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Lichen aureus (LA) is a rare variant of pigmented purpuric dermatosis. There are few Chinese cases of LA documented in the literature in English. We aimed to investigate the clinical and histopathological characteristics of LA in a series of Chinese patients. Read More

J Dtsch Dermatol Ges 2015 Nov;13(11):1073-88; quiz 1089

Division of Environmental Dermatology and Venereology, Department of Dermatology and Venereology, Medical University Graz, Austria.

Similar to all eczematous disorders, irritant and allergic contact dermatitis are primarily defined by their morphology. In addition, the diagnosis of this specific reaction pattern on the skin (and mucous membranes) also requires prior exposure (direct or indirect) to an allergen or irritant. While it is quite easy to give a textbook description of the typical features of eczema, its clinical manifestations in daily practice are diverse and frequently uncharacteristic. Read More

Pediatr Dermatol 2015 Mar-Apr;32(2):291-2. Epub 2015 Jan 30.

Department of Dermatology, Massachusetts General Hospital, Boston, Massachusetts.

Eczematid-like purpura of Doucas and Kapetanakis is a subtype of the pigmented purpuric dermatoses, a group of uncommon dermatoses of unclear etiology characterized by purpura, petechiae, and hyperpigmentation. The Doucas and Kapetanakis subtype is rare in children, and its subtle findings can initially be overlooked and mistaken for other, more common dermatologic disorders in this age group. We present a case eczematid-like purpura of Doucas and Kapetanakis in an 11-year-old boy initially treated as eczema. Read More

Pan Afr Med J 2015 17;20:144. Epub 2015 Feb 17.

Service de Dermatologie Vénérologie CHU Ibn Sina, Rabat, Maroc.

JAMA Dermatol 2014 Feb;150(2):182-4

Ronald O. Perelman Department of Dermatology, New York University Langone Medical Center, New York.

IMPORTANCE Medications as well as chemical and food exposures have been causally linked to the development of pigmented purpuric dermatosis (PPD). We describe herein what is to our knowledge the first reported case of isotretinoin-induced PPD. OBSERVATIONS A woman in her 30s presented with purpura annularis telangiectodes of Majocchi on the lower extremities 2 months after initiating isotretinoin for the treatment of refractory nodulocystic acne. Read More

Eur J Dermatol 2013 Sep-Oct;23(5):701-2

Department of Dermatology, Kyoto University School of Medicine, 54 Shogoin-Kawara, Sakyo, Kyoto 606-8507, Japan.

Am J Clin Dermatol 2014 Feb;15(1):65-70

Dermatology Clinic, Ataturk Training and Research Hospital, Bilkent way, 3. Street, Ankara, 06800, Turkey,

Background: The relationship between skin diseases and extracutaneous complications in diabetes mellitus (DM) is unclear.

Objective: We aimed to investigate the relationship between skin disorders and diabetic neuropathy, nephropathy, and retinopathy in patients with DM.

Methods: A total of 750 patients with DM were prospectively enrolled. Read More

ISRN Allergy 2013 Sep 15;2013:361746. Epub 2013 Sep 15.

Department of Biomedical Science and Human Oncology, Section of Dermatology, University of Bari, Piazza Giulio Cesare 1, 70124 Bari, Italy.

Irritant or allergic contact dermatitis usually presents as an eczematous process, clinically characterized by erythematoedematovesicous lesions with intense itching in the acute phase. Such manifestations become erythematous-scaly as the condition progresses to the subacute phase and papular-hyperkeratotic in the chronic phase. Not infrequently, however, contact dermatitis presents with noneczematous features. Read More

Pol J Pathol 2013 Jun;64(2):157-9; answer 160

Grzegorz Dyduch, Department of Pathomorphology, ul. Grzegórzecka 16, 31-351 Kraków.

We report a pediatric patient with granulomatous variant of pigmented purpuric dermatitis of 8 years duration. Read More

Photodermatol Photoimmunol Photomed 2013 Apr;29(2):97-9

Department of Dermatology, Istanbul Medeniyet University, Goztepe Research and Training Hospital, Dermatology, Istanbul, Turkey.

Eczematid-like purpura of Doucas and Kapetanakis is a type of pigmented purpuric dermatoses (PPDs) with eczematous changes in the purpuric surface. A 10-year-old male and a 44-year-old male patients were admitted to our clinics for itching and flaking of the skin rashes. Based on the clinical and histopathological evaluations, the rashes were identified as eczematid-like PPDs of Doucas and Kapetanakis. Read More

Acta Dermatovenerol Croat 2012 ;20(3):181-6

Polyclinic Department of Dermatology and Venereology, Dubrava University Hospital, Zagreb, Croatia.

Hereditary hemochromatosis (HHC) is a common genetic disorder of iron overload, caused by mutations in the HFE gene. If untreated, abnormal accumulation of iron may lead to organ damage and premature death. Significant changes in the symptomatology of HHC have been observed in recent years, and its full clinical expression is rarely seen. Read More

Acta Derm Venereol 2013 Jan;93(1):95-6