30,452 results match your criteria Pigmented Lesions of the Eyelid


Immunotoxic effects of 4-nonylphenol on Clarias gariepinus: Cytopathological changes in hepatic melanomacrophages.

Aquat Toxicol 2018 Dec 3;207:83-90. Epub 2018 Dec 3.

Medical Physiology Department, Faculty of Medicine, Assiut University, Assiut, Egypt.

Melanomacrophage centres (MMCs) play a key role in the immune response in fish. They are considered sensitive bio-monitoring structures with roles in the assessment of toxicant impacts. The aim of this study was to examine the potential histopathological effect of 4-nonylphenol (4-NP) on hepatic MMCs in Clarias gariepinus. Read More

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December 2018

Molecular and cellular basis of depigmentation in vitiligo patients.

Exp Dermatol 2018 Dec 10. Epub 2018 Dec 10.

Institut Curie, PSL Research University, INSERM U1021, Normal and Pathological Development of Melanocytes, Orsay, France.

Vitiligo is a chronic skin disease characterized by the appearance of zones of depigmentation. It is mostly described as an autoimmune disease in which the immune system destroys the melanocytes. Consistent with this origin, genetic studies have implicated genes encoding proteins mediating the immune response targeting melanocytes in the etiology of this disease, together with proteins specific to these cells. Read More

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December 2018
1 Read

Prenatal development of retina in buffalo (Bubalus bubalis).

Anat Histol Embryol 2018 Dec 10. Epub 2018 Dec 10.

Department of Veterinary Anatomy, Guru Angad Dev Veterinary & Animal Sciences University, Ludhiana, India.

The development of retina in Indian buffalo (Bubalus bubalis) has not been reported previously. The aim of the present study was therefore to report the major landmarks and the time course in the development of retina. Serial histological sections of Indian buffalo embryos and foetuses were used as group1 (<20. Read More

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December 2018

High-resolution, in vivo multimodal photoacoustic microscopy, optical coherence tomography, and fluorescence microscopy imaging of rabbit retinal neovascularization.

Light Sci Appl 2018 5;7:103. Epub 2018 Dec 5.

1Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48105 USA.

Photoacoustic microscopy (PAM) is an emerging imaging technology that can non-invasively visualize ocular structures in animal eyes. This report describes an integrated multimodality imaging system that combines PAM, optical coherence tomography (OCT), and fluorescence microscopy (FM) to evaluate angiogenesis in larger animal eyes. High-resolution in vivo imaging was performed in live rabbit eyes with vascular endothelial growth factor (VEGF)-induced retinal neovascularization (RNV). Read More

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December 2018

Draft Genome Sequence of " Spirobacillus cienkowskii," a Pathogen of Freshwater Species, Reconstructed from Hemolymph Metagenomic Reads.

Microbiol Resour Announc 2018 Dec 6;7(22). Epub 2018 Dec 6.

Department of Land, Air, and Water Resources, University of California, Davis, California, USA.

We report here the near-complete genome sequence of " Spirobacillus cienkowskii," a spiral-shaped, red-pigmented uncultivated bacterial pathogen of spp. The genome is 2.74 Mbp in size, has a GC content of 32. Read More

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December 2018

[Discrasia linfoide epiteliotrópica de células T. Tratamiento con radiación ultravioleta].

Gac Med Mex 2018 ;154(Supp 2):S41-S49

Unidad de Fototerapia. Hospital General Dr. Manuel Gea González, Ciudad de México, México.

Introduction: T-cell lymphoid dyscrasia is a group of different, infrequent, epitheliotropic inflammatory dermatosis that precede cutaneous T-cell lymphomas. Treatment with ultraviolet radiation is safe and efficacious.

Objective: To describe responses to treatment, secondary effects and complications. Read More

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January 2018

Acquired diffuse slate-grey facial dyspigmentation due to henna: an unrecognized cause of pigment contact dermatitis in Korean patients.

Eur J Dermatol 2018 Oct;28(5):644-648

Department of Dermatology, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Henna is a vegetable hair dye that can be used by individuals who are sensitized to oxidative dyes due to low allergenicity. The reported incidence of slate-grey facial dyspigmentation following the use of henna hair dye is extremely rare. This study aimed to identify the clinical, dermoscopic, and histopathological features of slate-grey facial dyspigmentation following the use of henna hair dye in Korean patients. Read More

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October 2018

Innocuous "foot lump" in patient with diabetes mellitus: A manifestation of phaeohyphomycosis.

Foot (Edinb) 2018 Nov 28;38:4-7. Epub 2018 Nov 28.

Department of Endocrinology, PGIMER, Chandigarh, 160012, IndiaIndia.

Invasive mycotic infection presenting as "foot lump" in an immunocompetent patient is extremely rare. The case highlights the difficulty in diagnosis of fungal infections of foot including attempts to isolate the fungus and non-response to anti-fungal agents. A 64-year-old lady with T2DM for four years presented with painless, gradually progressive swelling over plantar aspect of left mid-foot for six months. Read More

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November 2018

Visual inspection and dermoscopy, alone or in combination, for diagnosing keratinocyte skin cancers in adults.

Cochrane Database Syst Rev 2018 Dec 3;12:CD011901. Epub 2018 Dec 3.

Institute of Applied Health Research, University of Birmingham, Birmingham, UK, B15 2TT.

Background: Early accurate detection of all skin cancer types is important to guide appropriate management, to reduce morbidity and to improve survival. Basal cell carcinoma (BCC) is almost always a localised skin cancer with potential to infiltrate and damage surrounding tissue, whereas a minority of cutaneous squamous cell carcinomas (cSCCs) and invasive melanomas are higher-risk skin cancers with the potential to metastasise and cause death. Dermoscopy has become an important tool to assist specialist clinicians in the diagnosis of melanoma, and is increasingly used in primary-care settings. Read More

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December 2018
3 Reads

Opposing Effects of PPARα Agonism and Antagonism on Refractive Development and Form Deprivation Myopia in Guinea Pigs.

Invest Ophthalmol Vis Sci 2018 Dec;59(15):5803-5815

School of Ophthalmology and Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China.

Purpose: To determine if drug-induced peroxisome proliferator-activated receptor α (PPARα) signal pathway modulation affects refractive development and myopia in guinea pigs.

Methods: Pigmented guinea pigs were randomly divided into normal vision (unoccluded) and form deprivation myopia (FDM) groups. Each group received daily peribulbar injections of either a vehicle or (1) PPARα agonist, GW7647, clofibrate, or bezafibrate or (2) PPARα antagonist, GW6471, for 4 weeks. Read More

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December 2018

Winogradskyella algae sp. nov., a marine bacterium isolated from the brown alga.

Antonie Van Leeuwenhoek 2018 Dec 5. Epub 2018 Dec 5.

G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch, Russian Academy of Sciences, Prospect 100 Let Vladivostoku, 159, Vladivostok, Russia, 690022.

An aerobic, Gram-negative, yellow-pigmented non-motile rod-shaped bacterium Kr9-9 was isolated from a brown alga specimen collected near the Kuril Islands. Based on the 16S rRNA gene sequence analysis strain Kr9-9 was assigned to the genus Winogradskyella, and its close phylogenetic neighbors were found to be Winogradskyella damuponensis KCTC 23552, Winogradskyella sediminis LMG 28075, and Winogradskyella rapida CCUG 59098 showing high similarities of 98.1%, 97. Read More

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December 2018
4 Reads

Rock substrate rather than black stain alterations drives microbial community structure in the passage of Lascaux Cave.

Microbiome 2018 Dec 5;6(1):216. Epub 2018 Dec 5.

Univ Lyon, Université Claude Bernard Lyon 1, CNRS, INRA, VetAgro Sup, UMR5557/1418 Ecologie Microbienne, 69622, Villeurbanne, France.

Background: The World-famous UNESCO heritage from the Paleolithic human society, Lascaux Cave (France), has endeavored intense microclimatic perturbations, in part due to high touristic pressure. These perturbations have resulted in numerous disturbances of the cave ecosystem, including on its microbial compartment, which resulted in the formation of black stains especially on the rock faces of the passage. We investigated the cave microbiome in this part of Lascaux by sampling three mineral substrates (soil, banks, and inclined planes) on and outside stains to assess current cave microbial assemblage and explore the possibility that pigmented microorganisms involved in stain development occur as microbial consortia. Read More

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December 2018

Development of a Pigmented Facial Lesion Scale based on darkness and extent of lesions in older veterans.

J Invest Dermatol 2018 Nov 30. Epub 2018 Nov 30.

Center for Dermatoepidemiology, Veterans Affairs Medical Center, Providence, Rhode Island, USA; Department of Dermatology, Alpert Medical School of Brown University, Providence, Rhode Island, USA.

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November 2018

An unusually pigmented colon.

Lancet Gastroenterol Hepatol 2018 Dec;3(12):884

University Hospital Coventry and Warwickshire, Clifford Bridge Road, Coventry, CV2 2DX, UK.

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December 2018

Pigmented skin lesions displaying regression features: dermoscopy and reflectance confocal microscopy criteria for diagnosis.

Exp Dermatol 2018 Dec 2. Epub 2018 Dec 2.

Centro Oncologico ad Alta Tecnologia Diagnostica, Azienda Unità Sanitaria Locale - IRCCS, Reggio Emilia, Italy.

Melanomas and nevi displaying regression features can be difficult to differentiate. To describe reflectance confocal microscopy features in benign and malignant pigmented skin lesions characterized by regression features in dermoscopy. Methods: Observational retrospective study. Read More

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December 2018
3 Reads

Acral and Multicentric Pigmented Bowen's Disease in HIV-Positive Patients: Report on Two Unusual Cases.

Indian J Dermatol 2018 Nov-Dec;63(6):506-508

Centro De Investigación En Enfermedades Infecciosas, Instituto Nacional De Enfermedades Respiratorias, Ismael Cosío Villegas, México City, México.

squamous cell carcinoma of the skin (SCCis or Bowen's disease) is a common intraepidermal cutaneous malignancy with a low invasive potential. Acral Bowen's disease is usually solitary, but multiple acral SCCis have been reported. Pigmented Bowen's disease is typically unilesional and characterized by a hyperpigmented plaque with a velvety of keratotic surface, which can eventually simulate melanoma clinically. Read More

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December 2018

Spatio-temporal regulation of Rx and mitotic patterns shape the eye-cup of the photoreceptor cells in Ciona.

Dev Biol 2018 Nov 28. Epub 2018 Nov 28.

Institute for Integrative Neurobiology and Department of Biology, Faculty of Science and Engineering, Konan University, Kobe 658-8501, Japan. Electronic address:

The ascidian larva has a pigmented ocellus comprised of a cup-shaped array of approximately 30 photoreceptor cells, a pigment cell, and three lens cells. Morphological, physiological and molecular evidence has suggested evolutionary kinship between the ascidian larval photoreceptors and vertebrate retinal and/or pineal photoreceptors. Rx, an essential factor for vertebrate photoreceptor development, has also been suggested to be involved in the development of the ascidian photoreceptor cells, but a recent revision of the photoreceptor cell lineage raised a crucial discrepancy between the reported expression patterns of Rx and the cell lineage. Read More

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November 2018

Bioactive compounds in rice on Italian market: pigmented varieties as a source of carotenoids, total phenolic compounds and anthocyanins, before and after cooking.

Food Chem 2019 Mar 11;277:119-127. Epub 2018 Oct 11.

CREA Research Centre for Food and Nutrition, Via Ardeatina 546, I-00178 Rome, Italy.

The aim of this study was to fully characterize the main pigmented rice varieties, available to consumers on the Italian market, in terms of carotenoids, total phenolic compounds and anthocyanins, and to investigate the effect of cooking on these components. Lutein was the main carotenoid in all samples under investigation (0.33-4. Read More

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A Deep Learning Approach to Vascular Structure Segmentation in Dermoscopy Colour Images.

Biomed Res Int 2018 1;2018:5049390. Epub 2018 Nov 1.

Department of Automatic Control and Robotics, AGH University of Science and Technology, Cracow, Poland.

Background: Atypical vascular pattern is one of the most important features by differentiating between benign and malignant pigmented skin lesions. Detection and analysis of vascular structures is a necessary initial step for skin mole assessment; it is a prerequisite step to provide an accurate outcome for the widely used 7-point checklist diagnostic algorithm.

Methods: In this research we present a fully automated machine learning approach for segmenting vascular structures in dermoscopy colour images. Read More

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November 2018
9 Reads

[miR-122-5p inhibits the proliferation of melanoma cells by targeting NOP14].

Nan Fang Yi Ke Da Xue Xue Bao 2018 Nov;38(11):1360-1365

Department of Dermatology, Guangzhou Institute of Dermatology, Guangzhou 510095, China.

Objective: To investigate the expression profile of miR-122-5p in melanoma tissues and the effect of miR-122-5p on the proliferation, cell cycle and apoptosis of human melanoma cell lines SK-MEL-110 and A375.

Methods: The expression profiles of miR-122-5p in melanoma and pigmented nevus tissues were detected using real-time fluorescence quantitative PCR (qRT-PCR). SK-MEL-110 and A375 cells transfected with miR-122-5p inhibitor or negative control inhibitor (NC) I were examined for miR-122- 5p expression using qRT-PCR and changes in cell proliferation, cell cycle and apoptosis using MTT assay or flow cytometry. Read More

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November 2018
4 Reads

MicroRNA-29 enhances autophagy and cleanses exogenous mutant αB-crystallin in retinal pigment epithelial cells.

Exp Cell Res 2018 Dec 1. Epub 2018 Dec 1.

School of Optometry and Ophthalmology and the Eye Hospital, Wenzhou Medical University, PR China; State Key Laboratory of Optometry, Ophthalmology, and Visual Science, Wenzhou, Zhejiang, 325027, PR China. Electronic address:

Retinal pigment epithelial cells (RPEs), a pigmented cell layer in the outer retina, are constantly exposed to photo-oxidative stress. Autophagy relieves the stress by removing oxidative protein adducts, protein aggregates, and damaged mitochondria. We previously found that miR-29 is downregulated in choroid/RPE tissue in a model of exudative age-related macular degeneration (AMD), suggesting that miR-29 deficiency may contribute to autophagy inhibition and AMD progression. Read More

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December 2018
1 Read

Pigmented lesion in the anterior chamber angle following multiple trans-scleral diode laser photocoagulation for congenital glaucoma.

Am J Ophthalmol Case Rep 2019 Mar 14;13:32-33. Epub 2018 Nov 14.

King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia.

Purpose: To describe a child with primary congenital glaucoma found to have pigment tissue proliferation in the angle following multiple applications of trans-scleral cyclophotocoagulation.

Observations: During examination under anaesthesia, a 4-year-old girl was found to have pigmented tissue overlying the trabecular meshwork. Anterior segment ocular coherence tomography confirmed mounds of abnormal tissue in the angle. Read More

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Carney complex: Two case reports and review of literature.

World J Clin Cases 2018 Nov;6(14):800-806

Department of Radiology, Peking Union Medical College Hospital, Beijing 100730, China.

Carney complex (CNC) is an extremely rare genetic syndrome of pigmented skin lesions, endocrine hyperfunction and myxoma. Given its diverse clinical manifestations, CNC is often misdiagnosed. Recognition of some special clinical manifestations and imaging features may help with the diagnosis. Read More

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November 2018
3 Reads

UVB-induced depletion of donor-derived dendritic cells prevents allograft rejection of immune-privileged hair follicles in humanized mice.

Am J Transplant 2018 Nov 30. Epub 2018 Nov 30.

Department of Dermatology, Seoul National University College of Medicine, Seoul, Korea.

Dendritic cells (DCs) are key targets for immunity and tolerance induction; they present donor antigens to recipient T cells by donor- and recipient-derived pathways. Donor-derived DCs, which are critical during the acute posttransplantation period, can be depleted in graft tissue by forced migration via UVB irradiation. Here, we investigated the tolerogenic potential of donor-derived DC depletion through in vivo and ex vivo UVB preirradiation (UV) combined with injection of anti-CD154 Ab into recipients in an MHC-mismatched hair follicle (HF) allograft model in humanized mice. Read More

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November 2018
1 Read

Non-Invasive Analysis of High-Risk Driver Mutations and Gene Expression Profiles in Primary Cutaneous Melanoma.

J Invest Dermatol 2018 Nov 27. Epub 2018 Nov 27.

Cockerell Dermatopathology, Dallas, TX.

Tools that help reduce the number of surgical biopsies performed on benign lesions have the potential to improve patient care. The pigmented lesion assay (PLA) is a non-invasive tool validated against histopathology that helps rule out melanoma and the need for surgical biopsies of atypical pigmented skin lesions. Genetic information is collected using adhesive patches and the expression of two genes, LINC00518 and PRAME, is measured. Read More

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November 2018
3 Reads

Malignant melanoma of conjunctiva: Diagnosis on fine-needle aspiration cytology.

J Lab Physicians 2018 Oct-Dec;10(4):453-456

Department of Pathology, Post Graduate Institute of Medical Education and Research, Dr. Ram Manohar Lohia Hospital, New Delhi, India.

Malignant melanoma of conjunctiva is an uncommon malignancy. The diagnosis is suspected clinically and confirmed on pathological examination. We present a case of a 63-year-old female with previous history of pigmented lesion in the right eye and subsequently diagnosed as malignant melanoma of right conjunctiva and cornea on fine-needle aspiration cytology and histopathology. Read More

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December 2018

Pigmented villonodular synovitis occurring in the temporomandibular joint.

Auris Nasus Larynx 2018 Nov 26. Epub 2018 Nov 26.

Department of Head and Neck Surgry, Tokyo Medical and Dental University, Japan.

Objective: Pigmented villonodular synovitis occurring in the region of the temporomandibular joint is a rare disease, requiring a review of the treatment method, follow-up period.

Method: Refer to the past literature, along with a retrospective search.

Results: An excision, including the skull base bone, was performed in all cases; however, recurrence was found in one case on which fractional excision was performed. Read More

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November 2018
1 Read

Pigmented pruritic macules in the genital area.

Cutis 2018 Oct;102(4):E21-E22

Division of Dermatology, Ohio State University Department of Internal Medicine, Columbus, Ohio, USA.

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October 2018

New record of Hydrozoa Distichopora violacea (Pallas, 1766) (Anthoathecata: Stylasteridae) from Andaman and Nicobar Islands, India.

Zootaxa 2018 Oct 31;4508(3):439-442. Epub 2018 Oct 31.

Zoological Survey of India, Andaman Nicobar Regional Centre, Port Blair-744102, Andaman and Nicobar Islands, India..

The class Hydrozoa consists of mostly marine and few freshwater organisms classified into 7 orders amongst which the order Anthoathecata consists of 48 families with approximately 1,140 valid species (Cartwright Collins 2007). Stylasteridae is one among the families that comprises the order Anthoathecata, and is characterized by a calcareous exoskeleton which is often brightly pigmented. The members of the family are commonly called lace corals. Read More

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October 2018

Mechanism of miR-137 regulating migration and invasion of melanoma cells by targeting PIK3R3 gene.

J Cell Biochem 2018 Nov 28. Epub 2018 Nov 28.

Department of Laboratory Medicine, Tongji hospital of Tongji University, Shanghai, China.

Objective: To investigate the effect of microRNA-137 (miR-137) on the migration and invasion of melanoma cells and its mechanism.

Methods: Quantitative real-time polymerase chain reaction (qRT-PCR) was used to detect the expression of miR-137 in melanoma tissues and cells. miR-137 mimics, phosphoinositide-3-kinase regulatory subunit 3 (PIK3R3) small interfering RNA and corresponding controls were transfected into A375 and WM451 cells by lipofection. Read More

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November 2018

Expert-Level Diagnosis of Nonpigmented Skin Cancer by Combined Convolutional Neural Networks.

JAMA Dermatol 2018 Nov 28. Epub 2018 Nov 28.

Vienna Dermatologic Imaging Research Group, Department of Dermatology, Medical University of Vienna, Vienna, Austria.

Importance: Convolutional neural networks (CNNs) achieve expert-level accuracy in the diagnosis of pigmented melanocytic lesions. However, the most common types of skin cancer are nonpigmented and nonmelanocytic, and are more difficult to diagnose.

Objective: To compare the accuracy of a CNN-based classifier with that of physicians with different levels of experience. Read More

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November 2018
5 Reads

Assessing the efficacy of a 10-point referral tool in the triaging of pigmented lesions to a Dermatology clinic.

An Bras Dermatol 2018 Nov/Dec;93(6):932-933

Department of Dermatology, NHS Lothian, Edinburgh, United Kingdom.

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January 2018

Descriptive dermoscopy terminology in Portuguese language in Brazil: a reproducibility analysis of the 3rd consensus of the International Dermoscopy Society.

An Bras Dermatol 2018 Nov/Dec;93(6):852-858

Pigmented Lesions Outpatient Clinic, Dermoscopy and Confocal Microscopy, Hospital Universitário Pedro Ernesto, Universidade do Estado do Rio de Janeiro, Rio de Janeiro (RJ), Brazil.

Background: Dermoscopy is a noninvasive complementary diagnostic method largely used in dermatology. Feasibility, accuracy, and reproducibility are key elements for a diagnostic method to be useful, hence the importance of the terminology used to describe dermoscopic criteria.

Objective: To evaluate the reproducibility of the English descriptive terminology proposed for dermoscopic criteria at the 3rd Consensus Meeting of the International Dermoscopy Society in Brazilian Portuguese. Read More

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October 2017

Evaluation of skin expression profiles of patients with vitiligo treated with narrow-band UVB therapy by targeted RNA-seq.

An Bras Dermatol 2018 Nov/Dec;93(6):843-851

Department of Biochemistry and Molecular Medicine, Facultad de Medicina, Universidad Autónoma de Nuevo León, Nuevo León, México.

Background: Vitiligo is characterized by a lack of pigmentation in the skin. To date, there are no studies that analyze the changes in gene expression in the skin of vitiligo patients in response to narrow-band ultraviolet B (nb-UVB) phototherapy treatment.

Objective: Explore the usefulness of new generation RNA sequencing in the identification of gene expression changes in the skin of vitiligo patients treated with nb-UVB phototherapy. Read More

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August 2017
1 Read

Artificial Pigmented Human Skin Created by Muse Cells.

Adv Exp Med Biol 2018 ;1103:255-271

Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan.

The skin composes physiological and chemical barrier and renews skin component cells throughout the human life. Melanocytes locate in the basal layer of the epidermis and produce melanin to protect the skin from ultraviolet. Melanin plays key roles in determining human skin and hair color. Read More

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January 2018

Breast Cancer Metastasis in the Skin with Hyperkeratotic Pigmentation Caused by Melanocyte Colonization.

Case Rep Oncol 2018 Sep-Dec;11(3):660-664. Epub 2018 Oct 23.

Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan.

Pigmented breast cancer in the skin caused by nonneoplastic melanocytes of epidermal origin is a rare condition of metastasis from breast cancer, but the pathogenesis of this phenomenon is almost unknown. In this report, we describe a case of breast cancer metastasis in the skin with prominent hyperkeratotic pigmentation caused by nonneoplastic melanocyte colonization. Immunohistochemical staining revealed that the metastatic tumor cells produced IL-23, which is reported not only to induce IL-17 but also to inhibit cell apoptosis in breast cancer cells, which affects tumor progression. Read More

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October 2018
3 Reads

What's in a name? A call for consistency in the classification of tenosynovial giant cell tumour.

Knee 2018 Dec 25;25(6):1322-1323. Epub 2018 Oct 25.

IRCCS Istituto Ortopedico Galeazzi, Via Riccardo Galeazzi, 4, 20161 Milan, Italy.

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December 2018

Treatment of benign pigmented lesions using a novel Dermal Cooling System.

Lasers Surg Med 2018 Nov 27. Epub 2018 Nov 27.

Department of Dermatology, University of California San Diego, La Jolla 92122, California.

Benign pigmented lesions are among the most common dermatologic diagnoses that patients seek treatments for. Treatment modalities range from cryotherapy to light and laser-based technologies. These treatments have been shown to be effective, yet may lead to dyschromia or significant downtime. Read More

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November 2018
1 Read

The Cliff Sign: A New Radiographic Sign of Hip Instability.

Orthop J Sports Med 2018 Nov 12;6(11):2325967118807176. Epub 2018 Nov 12.

Department of Orthopaedic Surgery, Stanford University School of Medicine, Stanford, California, USA.

Background: The preoperative diagnosis of hip microinstability is challenging. Although physical examination maneuvers and magnetic resonance imaging findings associated with microinstability have been described, there are limited reports of radiographic features. In patients with microinstability, we observed a high incidence of a steep drop-off on the lateral edge of the femoral head, which we have named the "cliff sign. Read More

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November 2018

A tiny facial pigmented macule: overcoming the diagnostic challenge.

Dermatol Pract Concept 2018 Oct 31;8(4):322-323. Epub 2018 Oct 31.

First Department of Dermatology, Aristotle University, Thessaloniki, Greece.

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October 2018
1 Read

Onychoscopy: an observational study in 237 patients from the Kashmir Valley of North India.

Dermatol Pract Concept 2018 Oct 31;8(4):283-291. Epub 2018 Oct 31.

Postgraduate Department of Dermatology, STD & Leprosy, Government Medical College, Srinagar, University of Kashmir, Jammu & Kashmir, India.

Background: Nail disorders comprise approximately 10% of all dermatological conditions. Because diagnosis is not always possible by clinical means alone, additional diagnostic procedures may be required at times. Dermoscopy of nails (onychoscopy) has shown promising results in diagnosing various nail disorders and also avoids time-consuming investigations such as culture and biopsy. Read More

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October 2018
2 Reads

Regressing Conjunctival Nevus in a Child.

J Ophthalmic Vis Res 2018 Oct-Dec;13(4):501-503

Liverpool Ocular Oncology Centre, St. Paul's Eye Unit, Royal Liverpool University Hospital, Liverpool, England, UK.

Purpose: To report a case exhibiting drastic regression of a conjunctival nevus in a child.

Case Report: Spontaneous regression of conjunctival nevus is uncommon. We report the case of a nine-year-old Caucasian boy presenting a conjunctival-pigmented lesion situated at the plica semilunaris that underwent a significant reduction in size and color over a period of 15 months. Read More

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November 2018
3 Reads

Lokivetmab therapy for pruritus in a dog with cutaneous mastocytosis.

Vet Dermatol 2018 Nov 26. Epub 2018 Nov 26.

Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, University of Georgia, 2200 College Station Road, Athens, GA, 30602, USA.

Background: Cutaneous mastocytosis (CM) is a rare disease of dogs characterized by rash, pruritus and proliferation of mast cells in the skin. Oral H1 antihistamines are recommended as the treatment to control pruritus.

Hypothesis/objective: To describe the effective treatment of pruritus associated with CM with lokivetmab in one dog. Read More

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November 2018
7 Reads

Amelanotic primary vaginal melanoma: A case report with cyto-histological correlations.

Diagn Cytopathol 2018 Nov 27. Epub 2018 Nov 27.

Pathology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.

Vaginal mucosa represents a rare site for primary melanoma. These neoplasms more commonly occur in the postmenopausal period, usually presenting with vaginal discharge, bleeding, or palpable mass. We report a case of an 89-year-old woman presenting with vaginal bleeding and a non-pigmented lesion in the lower third of the vagina at the gynaecological examination. Read More

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November 2018
1 Read

SCY-078, A Novel Fungicidal Agent, Demonstrates Distribution to Tissues Associated with Fungal Infections During Mass Balance Studies with IV and PO C-SCY-078 in Albino and Pigmented Rats.

Antimicrob Agents Chemother 2018 Nov 26. Epub 2018 Nov 26.

SCYNEXIS, Inc., Jersey City, New Jersey

SCY-078, a fungicidal ß-1,3-glucan synthesis inhibitor, administered as intravenous or oral [C]-SCY-078 to rat, distributed primarily into tissues associated with invasive fungal disease (kidney, lung, liver, spleen, bone marrow, muscle, vaginal tissue, and skin) to levels exceeding plasma. Oral fraction absorbed was ∼40%. Elimination was primarily via bile and feces (∼90%) and urine (∼1. Read More

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November 2018
2 Reads

Les difficultés du diagnostic : du carcinome basocellulaire aux tumeurs trichoblastiques: From basal cell carcinoma to trichoblastic tumors: a diagnostic challenge.

Authors:
B Cribier

Ann Dermatol Venereol 2018 Nov;145 Suppl 5:VS3-VS11

Clinique dermatologique, hôpitaux universitaires de Strasbourg, 1, place de l'Hôpital, 67091 Strasbourg cedex, France. Electronic address:

Basal cell carcinoma (BCC) is a very common tumor, of which the diagnosis is generally easy. Clinical prediction of histopathological subtype however is however often difficult, i.e. Read More

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November 2018
2 Reads

Characterization of a tissue-engineered choroid.

Acta Biomater 2018 Nov 23. Epub 2018 Nov 23.

Département d'ophtalmologie et d'ORL-CCF, Faculté de médecine, Université Laval, Québec, QC, Canada; Centre de recherche du CHU de Québec-UL, Axe médecine régénératrice, Québec, QC, Canada; Centre de recherche en organogénèse expérimentale de l'Université Laval/LOEX, Québec, QC, Canada. Electronic address:

The choroid of the eye is a vascularized and pigmented connective tissue lying between the retina and the sclera. Increasing evidence demonstrates that, beyond supplying nutrients to the outer retina, the different choroidal cells contribute to the retina's homeostasis, especially by paracrine signaling. However, the precise role of each cell type is currently unclear. Read More

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November 2018
6 Reads

Distinct Genomic Patterns in Pigmented Epithelioid Melanocytoma: A Molecular and Histologic Analysis of 16 Cases.

Am J Surg Pathol 2018 Nov 20. Epub 2018 Nov 20.

Dermatology, Feinberg School of Medicine, Northwestern University.

Pigmented epithelioid melanocytoma (PEM) is considered an intermediate grade melanocytic lesion that is histologically indistinguishable from epithelioid blue nevi associated with Carney complex. PEM are characterized by an intradermal population of heavily pigmented epithelioid-shaped melanocytes along with some spindled and dendritic melanocytes with frequent melanophages. These melanocytic tumors occasionally involve regional lymph nodes but only rarely result in distant metastases. Read More

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November 2018
4 Reads

Pantothenate auxotrophy of Methylobacterium spp. isolated from living plants.

Biosci Biotechnol Biochem 2018 Nov 26:1-9. Epub 2018 Nov 26.

a Division of Applied Life Sciences, Graduate School of Agriculture , Kyoto University , Kyoto , Japan.

A number of pink-pigmented facultative methylotrophs (PPFMs) belonging to Methylobacterium spp. isolated from living plant samples were found to require B vitamins for their growth in minimal medium, and most B vitamin-auxotrophic PPFMs required pantothenate (vitamin B). Further investigation of pantothenate auxotrophy using the representative strain Methylobacterium sp. Read More

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November 2018