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Zhonghua Yan Ke Za Zhi 2019 Nov;55(11):847-853

Department of Ophthalmology, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China.

To investigate the anatomical region, histopathological classification and histogensis distribution of ocular mass lesions in South China. Retrospective cases study. The clinical and pathological data of 7 910 samples with ocular (adnexal) tumors or proliferative lesions which were examined from January 2000 to May 2018 were retrospectively retrieved. Read More

Graefes Arch Clin Exp Ophthalmol 2019 Aug 16;257(8):1783-1788. Epub 2019 May 16.

Department of Ophthalmology, Leiden University Medical Center, P.O. Box 9600, 2300 RC, Leiden, The Netherlands.

Purpose: In primary conjunctival melanoma (CoM), one of the characteristics that is associated with an increased risk of metastases and death is a lack of tumour pigmentation. The aim of this study was to investigate whether the degree of pigmentation of CoM recurrences relates similarly to clinical outcome.

Methods: A data set of 177 patients with a CoM recurrence from the Wills Eye Hospital (USA) and the Leiden University Medical Center (The Netherlands) was analysed. Read More

Cesk Slov Oftalmol Winter 2018;74(3):92-97

The etiology of papilloma formation is multifactorial. There is a strong association between human papillomavirus (HPV) and the development of these conjunctival lesions. HPV is tumorigenic and commonly produces benign tumors with low malignant potential. Read More

Dermatol Surg 2019 07;45(7):898-905

University of Washington School of Medicine, Spokane, Washington.

Background: Lateral tarsal strip (LTS) and medial spindle (MS) procedures are surgical techniques used to address cicatricial ectropion.

Objective: To evaluate the clinical characteristics and efficacy of simultaneous LTS and MS procedures for repair of cicatricial ectropion occurring after dermatologic surgeries.

Methods: A retrospective review of all cases of symptomatic, cicatricial, lateral, and medial punctal ectropion in 1 author's (C. Read More

Eye (Lond) 2019 05 18;33(5):767-771. Epub 2018 Dec 18.

Jules'Gonin Eye Hospital, University of Lausanne, Lausanne, Switzerland.

Purpose: To report the clinical and histopathologic features of two cases of eyelids metastases from uveal melanoma diagnosed in a metachronous and synchronous fashion.

Methods: Monocentric retrospective case series of histopathologically proven eyelids metastases from uveal melanoma at our institution.

Results: Two patients were presented to our hospital for upper eyelids pigmented and firm lesions. Read More

Toxicol Pathol 2018 10 22;46(7):799-820. Epub 2018 Oct 22.

2 Preclinical Development, Alcon Research Ltd., Fort Worth, Texas, USA.

Information on background changes in the ocular tissues of rabbits ( Oryctolagus cuniculus), a common species employed in ophthalmic toxicology studies, is sparse. This complicates interpretation of changes in light of small sample sizes on any single study. The purpose of this publication is to document the interstudy incidence of spontaneous or iatrogenic changes occurring in eyes of control rabbits. Read More

J Fr Ophtalmol 2018 May;41(5):475-476

Service d'ophtalmologie, hôpital militaire Mohamed V, faculté de médecine et de pharmacie Rabat, université Mohammed V, 10000 Rabat, Maroc.

Ophthalmology 2018 08 15;125(8):1189-1198. Epub 2018 Mar 15.

Bascom Palmer Eye Institute, University of Miami, Miami, Florida. Electronic address:

Purpose: Blue nevus is a melanocytic tumor that is commonly found in the skin. Extracutaneous presentations, including the ocular surface, are rare. As such, the purpose of this study was to characterize the clinical features and clinical course of congenital melanocytic tumor (blue nevus) of the conjunctiva. Read More

PLoS One 2018 14;13(2):e0192908. Epub 2018 Feb 14.

University of Szeged, Department of Ophthalmology, Szeged, Hungary.

Purpose: Conjunctival naevi are the most frequently diagnosed primary melanocytic lesions of the conjunctiva. The clinical manifestations are greatly variable which may result in diagnostic difficulties and differential diagnostic confusions. Therefore aims of the present study were: 1) to assess the morphologic features of conjunctival naevi; 2) to delineate the anterior segment optical coherence tomography (AS-OCT) characteristics of these lesions; 3) to compare AS-OCT and ultrasound biomicroscopy (UBM) as diagnostic tools in these alterations and 4) to correlate histological results with the AS-OCT pictures in case of surgically excised naevi. Read More

Invest Ophthalmol Vis Sci 2018 01;59(1):117-121

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, United States.

Purpose: To evaluate BRAF, NRAS, and GNAQ mutations in surgical specimens of common and blue conjunctival melanocytic nevi.

Methods: Surgical specimens from 25 conjunctival melanocytic nevi (23 common and 2 blue) of 25 patients were evaluated. All common nevi were analyzed immunohistochemically for the expression of BRAF V600E or NRAS Q61R. Read More

Arch Craniofac Surg 2016 Sep 23;17(3):176-179. Epub 2016 Sep 23.

Department of Pathology, Soonchunhyang University Seoul Hospital, Soonchunhyang University College of Medicine, Seoul, Korea.

Primary cutaneous mucinous carcinoma (PCMC) is a rare low-grade malignant neoplasm derived from the eccrine glands. PCMC most commonly arises in the head and neck, with the eyelid being the most common site of origin. This case report describes a 51-year-old male with a painless, pigmented superficial nodular lesion over his right lower eyelid. Read More

J Vet Diagn Invest 2017 Jul 3;29(4):483-488. Epub 2017 May 3.

Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado (Hughes).

Pigmented tumors have been reported infrequently in captive deer. We document herein the clinical progression and gross and histopathologic features of pigmented tumors diagnosed as melanoma and pigmented schwannoma in 11 white fallow deer ( Dama dama). Affected animals were part of a captive herd maintained at a drive-through park in southern Oregon and were 5-17 y of age during the study period (2004-2013). Read More

Cornea 2017 Jun;36(6):747-748

*Ophthalmic Oncology Service, Memorial Sloan-Kettering Cancer Center, New York, NY; †Department of Ophthalmology, Weill Cornell Medical College, New York, NY; ‡Department of Pathology, Dermatopathology Service, Memorial Sloan-Kettering Cancer Center, New York, NY; and §Pathology and Laboratory Services, Duke University Health System, Durham, NC.

Purpose: To present a novel case of ocular argyrosis mimicking conjunctival melanoma.

Methods: A 48-year-old man who is a jewelry manufacturer presented with raised pigmented lesions in the inferior fornices of both eyes. Brown-black colored, follicle-like, masses were observed in both fornices. Read More

Ocul Immunol Inflamm 2018 1;26(6):897-899. Epub 2017 Feb 1.

b Shahid Beheshti Hospital, Kashan University of Medical Sciences , Kashan , Iran.

Importance: Lichen planus pigmentosus (LPP) is an exclusive form of lichen planus (LP) characterized by pigmentary incontinence in histopathologic slides.

Observations: We report a known case of LPP with ocular manifestations including pigmented eyelid margins and conjunctival and corneal pigmented lesions. Histopathologic and confocal scanning findings of these lesions were compatible with the diagnosis of underlying systemic disease. Read More

Arch Soc Esp Oftalmol 2017 Nov 5;92(11):547-551. Epub 2017 Jan 5.

Departamento de Anatomía Patológica, Hospital Virgen de los Lirios, Alcoy, Alicante, España.

Case Report: An 87-year-old male presented with a slow-growing, painless and well defined nodule in the upper eyelid. The tumour measured 1cm, and was pigmented and adhered to deep planes. The histopathology analysis was compatible with renal cell carcinoma. Read More

Rev Stomatol Chir Maxillofac Chir Orale 2016 Dec 4;117(6):433-437. Epub 2016 Oct 4.

Service de chirurgie maxillo-faciale et plastique, hôpital Necker-Enfants-Malades, AP-HP, 149, rue de Sèvres, 75015 Paris, France; Centre de référence des malformations faciales et de la cavité buccale, MAFACE, AP-HP, 75015 Paris, France; Université Paris Descartes, 75005 Paris, France. Electronic address:

Introduction: "Café au lait" spots (CLS) are pigmented skin lesions principally located at the trunk and the limbs. Histologically, CLSs consist in an excessive pigmentation of the epidermis, with no risk of malignant transformation. The "kissing" nevus is a rare pigmented congenital nevus affecting both lower and upper eyelids in a mirror layout. Read More

Balkan Med J 2016 Jul 1;33(4):477-9. Epub 2016 Jul 1.

Bursa Pathology Center, Bursa, Turkey.

Background: Melanocytic nevus is a rare occurrence in the tarsal conjunctiva and only 7 well-described cases have been reported previously in the English literature.

Case Report: The medical records of 4 patients with tarsal conjunctival melanocytic nevus were reviewed, together with the relevant literature. All patients (3 women and 1 man; age range: 17 - 40 years) had been referred with a suspicion of melanoma. Read More

Middle East Afr J Ophthalmol 2016 Jul-Sep;23(3):247-9

Department of Research, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia.

Purpose: To evaluate the outcomes of argon laser photoablation of benign conjunctival pigmented nevi with different clinical presentations.

Patients And Methods: This interventional case series was conducted between July 2014 and January 2015. Patients presenting with benign conjunctival nevi were included. Read More

Surv Ophthalmol 2016 Mar-Apr;61(2):228-35. Epub 2015 Oct 22.

Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, USA; Department of Ophthalmology, Ophthalmic Plastic Surgery, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA.

A 16-year-old boy developed over a 2-month interval a lightly pigmented left upper eyelid lesion measuring 1.5 mm in greatest diameter that, when excised, microscopically was hypercellular and composed almost exclusively of nonpigmented epithelioid cells that created florid, large intraepidermal junctional nests and sheets and nests of subepidermal cells. The diagnosis was a Spitz nevus. Read More

J Anim Sci 2015 Jul;93(7):3654-60

Cancer of the eye in cattle with white faces occurs less frequently in cattle with pigmented eyelids. Corneoscleral pigmentation is related to eyelid pigmentation and occurrence of lesions that may precede cancer. Objectives of this study were to assess 1) variation in the proportion of eyelid and corneoscleral pigmentation in Hereford, Bos taurus, and Bos indicus crossbreds and 2) the occurrence of lesions with the presence of pigmentation in those areas. Read More

J Neurosci Rural Pract 2015 Jul-Sep;6(3):417-9

Department of Plastic Surgery, Indira Gandhi Medical College, Shimla, Himachal Pradesh, India.

A kissing nevus is a type of congenital compound nevus that affects equal portions of the upper and lower eyelid, and it extends to the lid margins. Congenital divided nevi of the eyelids are a rare melanocytic lesion. Only 30 patients are reported in the literature. Read More

Ocul Surf 2015 Jul 6;13(3):226-35. Epub 2015 Apr 6.

Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami, Miami, FL, USA. Electronic address:

Purpose: To evaluate the use of a commercially available, high-resolution, spectral-domain optical coherence tomography (HR-OCT) device in the diagnosis of corneal and conjunctival pathologies, with a focus on malignant lesions.

Methods: Eighty-two eyes of 71 patients were enrolled in this prospective case series, including 10 normal eyes, 21 with ocular surface squamous neoplasia (OSSN), 24 with a pterygium or pingueculum, 3 with lymphoma, 18 with pigmented conjunctival lesions (nevus, flat melanosis, or melanoma), and 6 with Salzmann nodular degeneration. Subjects were imaged using photography and HR-OCT (RTVue, Optovue, Fremont, CA). Read More

Pediatr Dermatol 2015 Jul-Aug;32(4):514-7. Epub 2015 May 4.

Department of Dermatology and Venereology, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey.

Background: Divided nevus is a rare entity that has been described for a special appearance of congenital melanocytic nevi (CMNs) occurring on the eyelid and penis. It is presumed that the formation of divided nevi is related with the embryologic development of the eyelid and penis, thus giving a hint about the occurrence time of CMN in utero. This article focuses on a formerly undescribed observation of another special clinical appearance of CMN discussing possible relation with embryogenesis. Read More

Vet Ophthalmol 2016 Mar 19;19(2):110-6. Epub 2015 Mar 19.

Department of Diagnostic Medicine/Pathobiology, Kansas State University, Manhattan, KS, USA.

Objective: To describe the clinical and histologic ocular anatomy of the black-tailed prairie dog (PD).

Animals Studied: Seventeen captive black-tailed PDs (11 males and six females), ranging in age from approximately 4 months to 4.5 years. Read More

Clin Dermatol 2015 Mar-Apr;33(2):197-206

Department of Dermatology, University of Connecticut Health Center, 21 South Road, Farmington, Connecticut. Electronic address:

Advances in laser technology in recent decades have increased the options for the treatment of dermatologic conditions of the eye and eyelid. Benign tumors can be laser-ablated with relative ease, and vascular and melanocytic lesions can be precisely targeted with modern lasers. In this contribution, we review treatment of periocular pigmented lesions, including melanocytic nevi and nevus of Ota; vascular lesions including telangiectasias, port wine stains, and infantile hemangiomas; hair removal; eyeliner tattoo removal; laser ablation of common benign periocular tumors, such as syringomas, xanthelasma, milia, and seborrheic keratoses; and laser resurfacing. Read More

Cornea 2015 Jan;34(1):90-3

*Department of Ophthalmology, University of Colorado, Aurora, CO; †Department of Dermatology, University of Colorado, Aurora, CO; ‡Texas Oculoplastic Consultants, Austin, TX; §Department of Ophthalmology, Division of Corneal and External Disease, University of Colorado, Aurora, CO; and ¶Department of Moh's Micrographic Surgery, University of Colorado, Aurora, CO.

Purpose: To report the case of a patient who initially presented with primary acquired melanosis (PAM) without atypia of the conjunctiva and later developed lentigo maligna of the eyelids and PAM with atypia of the conjunctiva. We illustrate the utility of combination topical therapy with adjunctive cryotherapy to treat extensive eyelid and conjunctival lesions.

Methods: Case report with a review of the current literature. Read More

Ophthalmic Plast Reconstr Surg 2016 Nov/Dec;32(6):e129-e130

*Department of Ophthalmology, Louisiana State University Health Sciences Center; †Department of Ophthalmology, Ochsner Clinic Foundation, New Orleans, Louisiana, U.S.A.; and ‡Charlotte Eye Ear Nose & Throat Associates, Charlotte, North Carolina, U.S.A.

Minocycline is a tetracycline antibiotic commonly used to treat acne and rosacea. Although pigmentation of the skin, nails, teeth, oral mucosa, and sclera is a well-recognized adverse outcome associated with minocycline, ocular pigmentation may be missed on routine examination. The authors present a case of a 43-year-old white woman who demonstrated bilateral pigmented palpebral conjunctival cysts after 12 months of minocycline therapy for cystic acne. Read More

An Bras Dermatol 2014 Mar-Apr;89(2):329-31

The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.

Kissing nevus is a curious type of nevus that was first described on the eyelids and rarely described on the penis. We report two cases of kissing nevus of the penis and review previously reported cases. The lesions of the kissing nevus of the penis showed characteristic mirror-image symmetry relative to the coronal sulcus. Read More

Australas J Dermatol 2014 Nov 14;55(4):289-91. Epub 2014 Jan 14.

Department of Ophthalmology, Flinders Medical Centre, University of Adelaide, South Australia, Australia.

The popularity of intense pulsed light (IPL) therapy continues to increase due to its relative safety, high skin coverage rate and ability to treat both vascular and pigmented lesions. An often-overlooked risk is the potential for IPL-induced ocular damage. The damage sustained can cause significant, persistent morbidity and can occur even with very limited IPL exposure to the eye. Read More

J Craniofac Surg 2014 Jan;25(1):e4-7

From the *Tianjin Medical University Eye Hospital, Tianjin Medical University Eye Institute; †Tianjin Medical University Eye Hospital; ‡Tianjin Eye Hospital, Tianjin Key Lab of Ophthalmology and Visual Science, Tianjin Eye Institute, Clinical College of Ophthalmology Tianjin Medical University; and §Pathology Department, Tianjin Medical University General Hospital, Tianjin, China.

The authors report a rare case of primary orbital melanoma (POM) combined with giant divided nevus of the eyelid. An 8-year-old Chinese girl is referred for evaluation of 2-month duration of exophthalmos with decreased vision, epiphora, and pain on her right eye. His presentation, imaging, biopsy, histopathology, and management are presented. Read More

Dermatol Online J 2013 Oct 16;19(10):20027. Epub 2013 Oct 16.

Fort Belvoir Community Hospital.

The divided or kissing nevus is an unusual congenital melanocytic nevus. By definition, these nevi appear on skin that separates during embryological development. These lesions have been reported on the eyelids, fingers, and rarely the penis. Read More

Middle East Afr J Ophthalmol 2013 Jul-Sep;20(3):187-92

Ophthalmic Research Center, Shahid Beheshti Medical University, Department of Ophthalmology, Labbafinejad Hospital, Tehran, Iran.

Purpose: The purpose of this study was to evaluate the demographics and clinical features of eyelid masses in a tertiary eye hospital over a 10-year period.

Materials And Methods: A retrospective chart review was performed for patients admitted with eyelid tumors from 2000 to 2010. Data were collected and analyzed on the demographic features, location of the tumor, types of treatment, and pathologic findings. Read More

Am J Ophthalmol 2013 Oct 24;156(4):813-18. Epub 2013 Jul 24.

Department of Ophthalmology and Visual Sciences, Washington University, St. Louis, Missouri. Electronic address:

Purpose: To describe a method for staged partial resection of congenital divided eyelid nevus. The rationale, technique, and outcomes for this approach are described.

Design: Retrospective chart review of a case series. Read More

Klin Oczna 2013 ;115(1):48-50

Department of Pediatric Ophthalmology with Centre for Treatment of Strabismus, Medical University of Bialystok, Poland.

The aim of our study is to report a case of pigmented squamous cell carcinoma of the palpebral conjunctiva referred to our clinic because of eye pain. A 86 year old patient suffering from eye pain due to a lower right eyelid tumour was admitted to our department. The basic ophthalmic examination and CT scans of orbits were performed. Read More

Insights Imaging 2013 Feb 12;4(1):119-33. Epub 2013 Jan 12.

Department of Radiology and Medical Imaging, University Hospital of Alexandroupolis, Democritus University of Thrace, Alexandroupolis, 68100, Greece,

The complex of myxomas, spotty skin pigmentation and endocrine overactivity, or Carney complex (CNC), is a familial multiple endocrine neoplasia and lentiginosis syndrome. CNC is inherited in an autosomal dominant manner and is genetically heterogeneous. Its features overlap those of McCune-Albright syndrome and other multiple endocrine neoplasia (MEN) syndromes. Read More

Vet Ophthalmol 2013 Jul 7;16 Suppl 1:117-22. Epub 2012 Nov 7.

Eye Care for Animals, 1021 E. 3300 S., Salt Lake City, UT 84106, USA.

This case report describes concurrent ocular melanosis and limbal melanocytoma in a 6-year-old Golden Retriever dog. Three years prior, the pet was examined for progressive corneal pigmentation and started on topical Tacrolimus but was subsequently lost to followup. Current ophthalmic examination revealed a large pigmented limbal mass and severe corneal pigmentation of the left eye as well as a small focal raised pigmented mass of the right third eyelid. Read More

Vet Ophthalmol 2013 Jul 9;16 Suppl 1:105-12. Epub 2012 Aug 9.

Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA.

A 6-year-old female spayed Chihuahua was presented for the evaluation of generalized pigmented cutaneous masses, one of which was present on the lower right eyelid. The dog was not on immunosuppressive medications and did not have historical or laboratory evidence of underlying endocrine disease, including hypothyroidism and hyperadrenocorticism. Histopathology, immunohistochemistry, and polymerase chain reaction of a cutaneous biopsy from the left antebrachium containing representative lesions confirmed viral papillomatosis. Read More

Nepal J Ophthalmol 2012 Jul-Dec;4(2):329-32

Department of Ophthalmology, Tribhuvan University Teaching Hospital, Maharajgunj, Kathmandu, Nepal.

Background: Kissing nevus is a congenital nevus in adjacent parts of the eyelids. Malignant transformation of kissing or divided nevi of the eyelids is rarely described.

Objective: To report a very rare case of malignant transformation of kissing nevus with ocular and extraocular spread. Read More

Orbit 2012 Apr;31(2):137-9

Guru Nanak Eye Centre, Maulana Azad Medical College, New Delhi, India.

Ophthalmomyiasis is a rare infection seen in susceptible individuals. We report a case of orbital myiasis in squamous cell carcinoma (SCC) in a patient of xeroderma pigmentosum. On presentation, reddish brown ulcerated mass with numerous maggots in orbit were seen. Read More

J Med Assoc Thai 2011 Dec;94 Suppl 6:S70-8

Division of Plastic Surgery, Department of Surgery, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.

Background: The challenges of management of facial congenital melanocytic nevi (CMN) are the balance of the risk of malignant transformation, surgical management and the long-term evaluation of the functional and cosmetic outcomes.

Objective: To present information on the long-term surgical management outcomes of patients with facial CMN, which may be applicable for future clinical and surgical approaches for these lesions.

Material And Method: A follow-up study was performed of patients with facial CMN that were clinically evaluated by the author at Srinagarind Hospital, Khon Kaen University, between 1993 and 2011. Read More

Ophthalmic Plast Reconstr Surg 2012 Sep-Oct;28(5):e107-8

Wills Eye Institute, Wills Eye Institute, Philadelphia, Pennsylvania 19057, USA.

A 62-year-old woman with a history of dry eyes was found to have unilateral pedunculated, nonpigmented palpebral conjunctival lesions. Excisional biopsy was performed, and the lesions were studied histopathologically. Microscopic examination of the lesions demonstrated exuberant granulation tissue with a granulomatous foreign body giant cell reaction surrounding pigmented and partially birefringent foreign material. Read More

Am J Ophthalmol 2012 Feb 6;153(2):242-252.e2. Epub 2011 Oct 6.

David G. Cogan Ophthalmic Pathology Laboratory, Massachusetts Eye and Ear Infirmary, Room 321, 243 Charles St, Boston, MA 02114, USA.

Purpose: To describe the clinical and microscopic features of pigmented basal cell carcinomas (pBCC) of the eyelid.

Design: Retrospective observational case series collected at one institution.

Methods: An analysis of clinical records, photographs, and histopathologic characteristics of 257 BCCs with a review of the literature. Read More

J Avian Med Surg 2011 Mar;25(1):44-9

Department of Clinical Sciences, Faculty of Veterinary Medicine, University of Tehran, Iran.

Mute swans (Cygnus olor), whooper swans (Cygnus cygnus), and mixed-breed domestic geese (Anser anser domesticus) were presented for necrotic lesions on the feet, eyelids, and beak. Individuals from the same collection of birds had developed identical lesions during March-September of each of the previous 3 years. Vesicular and necrotic dermatitis involved only nonfeathered and nonpigmented areas of the integument. Read More

Ann Plast Surg 2012 Feb;68(2):166-70

Department of Ophthalmology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.

Currently, there is a lack of comprehensive data regarding clinicopathologic characteristics and surgical treatment of divided nevus of the eyelids. Here clinicopathologic features and reconstructive procedures performed on 73 patients were described. We showed that the lesion was randomly located on both eyes with a predominant incidence in females. Read More

J Cutan Aesthet Surg 2011 Jan;4(1):61-4

Department of Oral and Maxillofacial Surgery, AME'S Dental College Hospital and Research Centre, Raichur, Karnataka, India.

Congenital nevi are present in approximately 2-3% of neonates. These lesions are present at birth. They are characterized by pigmented lesions with regular margins, smooth or lobular surfaces and occasionally have long coarse hair. Read More

Ophthalmic Plast Reconstr Surg 2011 Sep-Oct;27(5):338-42

Department of Ophthalmology, Harvard Medical School, Boston, MA, USA.

Purpose: To describe the first isolated and focal benign blue nevus of the eyelid margin.

Methods: Review of clinical, histopathologic, and immunohistochemical characteristics and relevant literature.

Results: A 93-year-old Caucasian woman with a flat, irregular, and deeply pigmented black growth of the left upper eyelid margin of unknown duration underwent a full-thickness eyelid excisional biopsy. Read More

Ophthalmic Plast Reconstr Surg 2011 Jul-Aug;27(4):e94-6

David G Cogan Laboratory of Ophthalmic Pathology, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts 02114, USA.

A 40-year-old man presented with a pigmented lesion of the palpebral conjunctiva and margin of the right lower eyelid. Because of suspicion of melanoma, the lesion was resected. Microscopic examination revealed 2 distinct components: a dominant blue nevus in the tarsus consisting of bland pigmented spindle and epithelioid cells that dissected among the orbicularis muscle fibers and meibomian glands, and a small subepithelial nevomelanocytic component with no overlying junctional activity. Read More

Ophthalmic Plast Reconstr Surg 2010 Nov-Dec;26(6):438-42

Department of Ophthalmology, New Jersey Medical School, Newark, New Jersey, USA.

Purpose: To describe 4 patients with histopathologically confirmed tarsal conjunctival nevi and to review the literature regarding nevi in this location.

Methods: Clinicopathologic series of 4 cases diagnosed at the New York Eye and Ear Infirmary between January 1990 and April 2009. PubMed was searched for reported cases of tarsal conjunctival nevi. Read More

Jpn J Ophthalmol 2010 May 25;54(3):244-6. Epub 2010 Jun 25.