136 results match your criteria Pigmented Lesions of the Eyelid


Hyperpigmented spots at fundus examination: a new ocular sign in Neurofibromatosis Type I.

Orphanet J Rare Dis 2021 03 23;16(1):147. Epub 2021 Mar 23.

Department of Dermatology and Venereology, Sapienza University of Rome, Policlinico Umberto I, Rome, Italy.

Background: Neurofibromatosis Type I (NF1), also termed von Recklinghausen disease, is a rare genetic disorder that is transmitted by autosomal dominant inheritance, with complete penetrance and variable expressivity. It is caused by mutation in the NF1 gene on chromosome 17 encoding for neurofibromin, a protein with oncosuppressive activity, and it is 50% sporadic or inherited. The disease is characterized by a broad spectrum of clinical manifestations, mainly involving the nervous system, the eye and skin, and a predisposition to develop multiple benign and malignant neoplasms. Read More

View Article and Full-Text PDF

Both Age and Disease Duration are Associated with Clinical Phenotype of Hori's Nevus in Chinese: A Retrospective Analysis of 497 Cases.

Clin Cosmet Investig Dermatol 2021 18;14:65-71. Epub 2021 Jan 18.

Aesthetic Department, Dermatology Hospital, Southern Medical University, Guangzhou, Guangdong 510091, People's Republic of China.

Background: Hori's nevus is a common pigmented disorder on the face, preferentially in females. The clinical features have not been well characterized.

Aim: To characterize the clinical features of Hori's nevus in Chinese adults. Read More

View Article and Full-Text PDF
January 2021

[Ocular manifestations and surgical treatment of the linear nevus sebaceous syndrome].

Zhonghua Yan Ke Za Zhi 2020 Nov;56(11):846-852

Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Key Laboratory of Ophthalmology & Visual Sciences, Beijing 100730, China.

To report the clinical and pathological features and surgical treatment of the linear nevus sebaceous syndrome. It was a retrospective case series study. The clinical records of 11 patients (14 eyes) who were diagnosed as linear nevus sebaceous syndrome between April 2009 and February 2018 at Beijing Tongren Hospital were analyzed. Read More

View Article and Full-Text PDF
November 2020

Anterior Segment OCTA of Melanocytic Lesions of the Conjunctiva and Iris.

Am J Ophthalmol 2021 02 12;222:137-147. Epub 2020 Sep 12.

Department of Ophthalmology, Leiden University Medical Center, Leiden, the Netherlands.

Purpose: To study the feasibility and diagnostic value of vascular imaging using optical coherence tomography (OCT)-angiography (OCTA) of melanocytic lesions of the conjunctiva and iris.

Design: Cross-sectional study.

Methods: Twenty-five patients with an untreated conjunctival lesion (5 melanoma, 13 nevus, 7 primary acquired melanosis [PAM]) and 52 patients with an untreated iris lesion (10 melanoma, 42 nevus) were included. Read More

View Article and Full-Text PDF
February 2021

Tick infestation masquerading as a nodule in the eye lid.

Nepal J Ophthalmol 2020 Jan;12(23):106-109

Hospital for Children, Eye, ENT and Rehabilitation Services (CHEERS).

Introduction: Ticks are ectoparasites which can lead to various blood borne diseases. Tick bite may resemble pigmented nevi, mole or nodule resulting a diagnostic dilemma. Tick bite in eye lid is rare and this case report describes tick bite in lower eye lid mimicking a traumatized pigmented nodule where the tick was identified only on magnification and was successfully removed mechanically. Read More

View Article and Full-Text PDF
January 2020

[Diagnosis and Therapy of Benign and Malignant Tumors of the Conjunctiva].

Klin Monbl Augenheilkd 2020 Sep 10;237(9):1143-1159. Epub 2020 Aug 10.

The aim of this paper is to give an overview of different benign and malignant epibulbar tumors. Categories can be made of the age of manifestation (paediatric tumors versus tumors of adults), the originating cell types (squamous cell tumors, melanocytic tumors, lymphomas or germ cell tumors) or genesis (proliferative, infectious or degenerating tumors). Most epibulbar tumors show lesions on the conjunctiva or the cornea. Read More

View Article and Full-Text PDF
September 2020

Conjunctival pigmented lesion: Clinicopathological analysis of 85 cases in Korean population.

Sci Rep 2019 12 3;9(1):18204. Epub 2019 Dec 3.

Department of Ophthalmology, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul, 03080, Korea.

To evaluate histopathological characteristics of conjunctival pigmented lesions and analyze clinical features related to histologic classification in Asian population, we analyzed medical records, anterior segment photographs, and histological specimen of 85 eyes who had undergone biopsy for pigmented conjunctival lesions at Seoul National University Hospital between 1999 and 2018. Compound nevus was the most common type of conjunctival pigmented lesions (67.1%), followed by conjunctival melanocytic intraepithelial neoplasia (primary acquired melanosis)(11. Read More

View Article and Full-Text PDF
December 2019

[A clinicopathological classification analysis of ocular mass lesions in 7 910 cases].

Zhonghua Yan Ke Za Zhi 2019 Nov;55(11):847-853

Department of Ophthalmology, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China.

To investigate the anatomical region, histopathological classification and histogensis distribution of ocular mass lesions in South China. Retrospective cases study. The clinical and pathological data of 7 910 samples with ocular (adnexal) tumors or proliferative lesions which were examined from January 2000 to May 2018 were retrospectively retrieved. Read More

View Article and Full-Text PDF
November 2019

Pigmentation of conjunctival melanoma recurrences and outcome.

Graefes Arch Clin Exp Ophthalmol 2019 Aug 16;257(8):1783-1788. Epub 2019 May 16.

Department of Ophthalmology, Leiden University Medical Center, P.O. Box 9600, 2300 RC, Leiden, The Netherlands.

Purpose: In primary conjunctival melanoma (CoM), one of the characteristics that is associated with an increased risk of metastases and death is a lack of tumour pigmentation. The aim of this study was to investigate whether the degree of pigmentation of CoM recurrences relates similarly to clinical outcome.

Methods: A data set of 177 patients with a CoM recurrence from the Wills Eye Hospital (USA) and the Leiden University Medical Center (The Netherlands) was analysed. Read More

View Article and Full-Text PDF

Cosmetically Challenging Congenital Melanocytic Nevi.

Ann Plast Surg 2019 05;82(5S Suppl 4):S306-S309

Division of Plastic and Reconstructive Surgery, Cedar-Sinai, Los Angeles, CA.

Background: Congenital melanocytic nevi (CMN) have a 1% to 5% lifetime risk for malignant transformation, with 50% of transformations occurring before the age of 5 years.The aim of this study is to assess the risk of melanoma development in pediatric patients with facial CMN involving the eyebrows, eyelid margins, and nasal alae where a margin of CMN was not excised to preserve these structures.

Methods: A retrospective chart review of all pediatric patients with CMN from 1986 to 2014 was performed to review demographic information, diagnosis, and number of surgeries. Read More

View Article and Full-Text PDF

Conjuctival lesions - the relationship of papillomas and squamous cell carcinoma to HPV infection.

Cesk Slov Oftalmol Winter 2018;74(3):92-97

The etiology of papilloma formation is multifactorial. There is a strong association between human papillomavirus (HPV) and the development of these conjunctival lesions. HPV is tumorigenic and commonly produces benign tumors with low malignant potential. Read More

View Article and Full-Text PDF

Simultaneous Lateral Tarsal Strip and Medial Spindle Procedures for Cicatricial Ectropion.

Dermatol Surg 2019 07;45(7):898-905

University of Washington School of Medicine, Spokane, Washington.

Background: Lateral tarsal strip (LTS) and medial spindle (MS) procedures are surgical techniques used to address cicatricial ectropion.

Objective: To evaluate the clinical characteristics and efficacy of simultaneous LTS and MS procedures for repair of cicatricial ectropion occurring after dermatologic surgeries.

Methods: A retrospective review of all cases of symptomatic, cicatricial, lateral, and medial punctal ectropion in 1 author's (C. Read More

View Article and Full-Text PDF

Eyelids metastases from uveal melanoma: clinical and histopathologic features of two cases and literature review.

Eye (Lond) 2019 05 18;33(5):767-771. Epub 2018 Dec 18.

Jules'Gonin Eye Hospital, University of Lausanne, Lausanne, Switzerland.

Purpose: To report the clinical and histopathologic features of two cases of eyelids metastases from uveal melanoma diagnosed in a metachronous and synchronous fashion.

Methods: Monocentric retrospective case series of histopathologically proven eyelids metastases from uveal melanoma at our institution.

Results: Two patients were presented to our hospital for upper eyelids pigmented and firm lesions. Read More

View Article and Full-Text PDF

Historical Data: Histopathology Lesions Observed in the Eyes of Control Rabbits in Topical Ocular Administration and Contact Lens Studies.

Toxicol Pathol 2018 10 22;46(7):799-820. Epub 2018 Oct 22.

2 Preclinical Development, Alcon Research Ltd., Fort Worth, Texas, USA.

Information on background changes in the ocular tissues of rabbits ( Oryctolagus cuniculus), a common species employed in ophthalmic toxicology studies, is sparse. This complicates interpretation of changes in light of small sample sizes on any single study. The purpose of this publication is to document the interstudy incidence of spontaneous or iatrogenic changes occurring in eyes of control rabbits. Read More

View Article and Full-Text PDF
October 2018

[Congenital "kissing Nevus" lid lesions].

J Fr Ophtalmol 2018 May;41(5):475-476

Service d'ophtalmologie, hôpital militaire Mohamed V, faculté de médecine et de pharmacie Rabat, université Mohammed V, 10000 Rabat, Maroc.

View Article and Full-Text PDF

Blue Nevi of the Ocular Surface: Clinical Characteristics, Pathologic Features, and Clinical Course.

Ophthalmology 2018 08 15;125(8):1189-1198. Epub 2018 Mar 15.

Bascom Palmer Eye Institute, University of Miami, Miami, Florida. Electronic address:

Purpose: Blue nevus is a melanocytic tumor that is commonly found in the skin. Extracutaneous presentations, including the ocular surface, are rare. As such, the purpose of this study was to characterize the clinical features and clinical course of congenital melanocytic tumor (blue nevus) of the conjunctiva. Read More

View Article and Full-Text PDF

Conjunctival melanocytic naevus: Diagnostic value of anterior segment optical coherence tomography and ultrasound biomicroscopy.

PLoS One 2018 14;13(2):e0192908. Epub 2018 Feb 14.

University of Szeged, Department of Ophthalmology, Szeged, Hungary.

Purpose: Conjunctival naevi are the most frequently diagnosed primary melanocytic lesions of the conjunctiva. The clinical manifestations are greatly variable which may result in diagnostic difficulties and differential diagnostic confusions. Therefore aims of the present study were: 1) to assess the morphologic features of conjunctival naevi; 2) to delineate the anterior segment optical coherence tomography (AS-OCT) characteristics of these lesions; 3) to compare AS-OCT and ultrasound biomicroscopy (UBM) as diagnostic tools in these alterations and 4) to correlate histological results with the AS-OCT pictures in case of surgically excised naevi. Read More

View Article and Full-Text PDF

BRAF, NRAS, and GNAQ Mutations in Conjunctival Melanocytic Nevi.

Invest Ophthalmol Vis Sci 2018 01;59(1):117-121

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, United States.

Purpose: To evaluate BRAF, NRAS, and GNAQ mutations in surgical specimens of common and blue conjunctival melanocytic nevi.

Methods: Surgical specimens from 25 conjunctival melanocytic nevi (23 common and 2 blue) of 25 patients were evaluated. All common nevi were analyzed immunohistochemically for the expression of BRAF V600E or NRAS Q61R. Read More

View Article and Full-Text PDF
January 2018

Primary Cutaneous Mucinous Carcinoma of the Eyelid.

Arch Craniofac Surg 2016 Sep 23;17(3):176-179. Epub 2016 Sep 23.

Department of Pathology, Soonchunhyang University Seoul Hospital, Soonchunhyang University College of Medicine, Seoul, Korea.

Primary cutaneous mucinous carcinoma (PCMC) is a rare low-grade malignant neoplasm derived from the eccrine glands. PCMC most commonly arises in the head and neck, with the eyelid being the most common site of origin. This case report describes a 51-year-old male with a painless, pigmented superficial nodular lesion over his right lower eyelid. Read More

View Article and Full-Text PDF
September 2016

Pigmented tumors in fallow deer ( Dama dama): 11 cases.

J Vet Diagn Invest 2017 Jul 3;29(4):483-488. Epub 2017 May 3.

Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado (Hughes).

Pigmented tumors have been reported infrequently in captive deer. We document herein the clinical progression and gross and histopathologic features of pigmented tumors diagnosed as melanoma and pigmented schwannoma in 11 white fallow deer ( Dama dama). Affected animals were part of a captive herd maintained at a drive-through park in southern Oregon and were 5-17 y of age during the study period (2004-2013). Read More

View Article and Full-Text PDF

Ocular Argyrosis Mimicking Conjunctival Melanoma.

Cornea 2017 Jun;36(6):747-748

*Ophthalmic Oncology Service, Memorial Sloan-Kettering Cancer Center, New York, NY; †Department of Ophthalmology, Weill Cornell Medical College, New York, NY; ‡Department of Pathology, Dermatopathology Service, Memorial Sloan-Kettering Cancer Center, New York, NY; and §Pathology and Laboratory Services, Duke University Health System, Durham, NC.

Purpose: To present a novel case of ocular argyrosis mimicking conjunctival melanoma.

Methods: A 48-year-old man who is a jewelry manufacturer presented with raised pigmented lesions in the inferior fornices of both eyes. Brown-black colored, follicle-like, masses were observed in both fornices. Read More

View Article and Full-Text PDF

Corneal Involvement by Lichen Planus Pigmentosus.

Ocul Immunol Inflamm 2018 1;26(6):897-899. Epub 2017 Feb 1.

b Shahid Beheshti Hospital, Kashan University of Medical Sciences , Kashan , Iran.

Importance: Lichen planus pigmentosus (LPP) is an exclusive form of lichen planus (LP) characterized by pigmentary incontinence in histopathologic slides.

Observations: We report a known case of LPP with ocular manifestations including pigmented eyelid margins and conjunctival and corneal pigmented lesions. Histopathologic and confocal scanning findings of these lesions were compatible with the diagnosis of underlying systemic disease. Read More

View Article and Full-Text PDF
September 2018

Eyelid metastasis as first presentation of renal cell carcinoma.

Arch Soc Esp Oftalmol 2017 Nov 5;92(11):547-551. Epub 2017 Jan 5.

Departamento de Anatomía Patológica, Hospital Virgen de los Lirios, Alcoy, Alicante, España.

Case Report: An 87-year-old male presented with a slow-growing, painless and well defined nodule in the upper eyelid. The tumour measured 1cm, and was pigmented and adhered to deep planes. The histopathology analysis was compatible with renal cell carcinoma. Read More

View Article and Full-Text PDF
November 2017

[Congenital "kissing" lesions: Nevus or "café au lait" spot?]

Rev Stomatol Chir Maxillofac Chir Orale 2016 Dec 4;117(6):433-437. Epub 2016 Oct 4.

Service de chirurgie maxillo-faciale et plastique, hôpital Necker-Enfants-Malades, AP-HP, 149, rue de Sèvres, 75015 Paris, France; Centre de référence des malformations faciales et de la cavité buccale, MAFACE, AP-HP, 75015 Paris, France; Université Paris Descartes, 75005 Paris, France. Electronic address:

Introduction: "Café au lait" spots (CLS) are pigmented skin lesions principally located at the trunk and the limbs. Histologically, CLSs consist in an excessive pigmentation of the epidermis, with no risk of malignant transformation. The "kissing" nevus is a rare pigmented congenital nevus affecting both lower and upper eyelids in a mirror layout. Read More

View Article and Full-Text PDF
December 2016

Melanocytic Nevus of the Tarsal Conjunctiva.

Balkan Med J 2016 Jul 1;33(4):477-9. Epub 2016 Jul 1.

Bursa Pathology Center, Bursa, Turkey.

Background: Melanocytic nevus is a rare occurrence in the tarsal conjunctiva and only 7 well-described cases have been reported previously in the English literature.

Case Report: The medical records of 4 patients with tarsal conjunctival melanocytic nevus were reviewed, together with the relevant literature. All patients (3 women and 1 man; age range: 17 - 40 years) had been referred with a suspicion of melanoma. Read More

View Article and Full-Text PDF

Argon Laser Photoablation for Treating Benign Pigmented Conjunctival Nevi.

Middle East Afr J Ophthalmol 2016 Jul-Sep;23(3):247-9

Department of Research, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia.

Purpose: To evaluate the outcomes of argon laser photoablation of benign conjunctival pigmented nevi with different clinical presentations.

Patients And Methods: This interventional case series was conducted between July 2014 and January 2015. Patients presenting with benign conjunctival nevi were included. Read More

View Article and Full-Text PDF

Spitz nevus arising in the eyelid of a teenager.

Surv Ophthalmol 2016 Mar-Apr;61(2):228-35. Epub 2015 Oct 22.

Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, USA; Department of Ophthalmology, Ophthalmic Plastic Surgery, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA.

A 16-year-old boy developed over a 2-month interval a lightly pigmented left upper eyelid lesion measuring 1.5 mm in greatest diameter that, when excised, microscopically was hypercellular and composed almost exclusively of nonpigmented epithelioid cells that created florid, large intraepidermal junctional nests and sheets and nests of subepidermal cells. The diagnosis was a Spitz nevus. Read More

View Article and Full-Text PDF
September 2016

Technical note: Digital quantification of eye pigmentation of cattle with white faces.

J Anim Sci 2015 Jul;93(7):3654-60

Cancer of the eye in cattle with white faces occurs less frequently in cattle with pigmented eyelids. Corneoscleral pigmentation is related to eyelid pigmentation and occurrence of lesions that may precede cancer. Objectives of this study were to assess 1) variation in the proportion of eyelid and corneoscleral pigmentation in Hereford, Bos taurus, and Bos indicus crossbreds and 2) the occurrence of lesions with the presence of pigmentation in those areas. Read More

View Article and Full-Text PDF

Kissing naevus arising from neural crest cells presenting as upper and the lower lid mass.

J Neurosci Rural Pract 2015 Jul-Sep;6(3):417-9

Department of Plastic Surgery, Indira Gandhi Medical College, Shimla, Himachal Pradesh, India.

A kissing nevus is a type of congenital compound nevus that affects equal portions of the upper and lower eyelid, and it extends to the lid margins. Congenital divided nevi of the eyelids are a rare melanocytic lesion. Only 30 patients are reported in the literature. Read More

View Article and Full-Text PDF