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J Dermatol 2022 May 24. Epub 2022 May 24.

Department of Dermatology, Venereology and Allergology, Faculty of Medicine, Medical University of Gdańsk, Gdańsk, Poland.

Despite rapid growth in the significance of dermoscopy in dermatological oncology, relatively little is yet known about the dermoscopic patterns of eyelid margin tumors. The aim of the study was to analyze the dermoscopic features of eyelid margin tumors. This was a retrospective, single-center, consecutive study which included clinical and dermoscopic analysis of eyelid margin tumors diagnosed at the Department of Dermatology, Venereology and Allergology at the Medical University of Gdańsk from 1 June 2016 to 31 December 2020. Read More

Orbit 2022 Apr 28:1-8. Epub 2022 Apr 28.

Department of Ophthalmology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.

Purpose: To describe two patients with blue nevi of the palpebral conjunctiva and to review the existing literature on common and cellular blue nevi of the conjunctiva.

Methods: Report of two cases and literature review.

Results: We present two cases of blue nevi in the palpebral conjunctiva: an atypical cellular blue nevus of the left upper eyelid and a common blue nevus around the lacrimal punctum of the left lower eyelid. Read More

Cureus 2021 Aug 9;13(8):e17029. Epub 2021 Aug 9.

Ophthalmic Plastic Surgery & Ocular Oncology, Advanced Eye Hospital & Institute, Mumbai, IND.

Pyogenic granuloma is a common, benign, vascular growth that often appears as a rapidly growing mass on mucus membrane-lined surfaces such as the conjunctiva. Conjunctival pyogenic granulomas are common following trauma, burst chalazion or ill-fitting prosthesis. Also known as 'lobular capillary hemangiomas', these lesions typically appear bright red, fleshy and pedunculated. Read More

Turk J Ophthalmol 2021 08;51(4):243-245

Ankara University Faculty of Medicine, Department of Pathology, Ankara, Turkey

A 29-year-old woman presented with dark-colored raised lesions on both eyelids since early childhood. Ophthalmological examination revealed pigmented verrucous lesions on her upper and lower eyelids bilaterally. The patient had a history of generalized tonic-clonic seizures. Read More

Ophthalmic Plast Reconstr Surg 2022 Mar-Apr 01;38(2):154-159

Clinico-Path Laboratory, Chembur, Mumbai, India.

Purpose: To report the epidemiology, histopathological spectrum, and surgical outcomes of peripunctal mass lesions.

Methods: Multicentric retrospective case series involving 6 centers in India. All cases of peripunctal masses with histopathological diagnoses and minimum follow up of 3 months were included. Read More

Anticancer Res 2021 Jun;41(6):3161-3167

Department of Ophthalmology and Ocular Oncology, Faculty of Medicine, Jagiellonian University Medical College, Krakow, Poland;

Background/aim: This study aimed to develop an algorithm allowing the differentiation between conjunctival melanoma and other melanocytic infiltrations of the conjunctiva, on the basis of a dermatoscopic examination.

Patients And Methods: A total of 160 conjunctival pigmented lesions were studied (40 melanomas and 120 non-melanoma conjunctival infiltrations). The clinical characteristics of the tumours were assessed with the use of dermatoscopic characteristics as described by Kittler, and with taking into consideration the typical characteristics of conjunctival lesions. Read More

Curr Opin Ophthalmol 2021 07;32(4):369-378

Bascom Palmer Eye Institute, Department of Ophthalmology University of Miami, Miami, Florida, USA.

Purpose Of Review: This review will discuss the utility of high-resolution anterior segment optical coherence tomography (HR-OCT), in-vivo confocal microscopy (IVCM) and ultrasound biomicroscopy (UBM) in characterizing and diagnosing various ocular surface tumors, namely ocular surface squamous neoplasia (OSSN), conjunctival lymphoma and conjunctival melanoma. The strengths and limitations of each imaging modality will be discussed along with the characteristics findings of each lesion on each imaging platform.

Recent Findings: HR-OCT can consistently be utilized in the clinic setting to distinguish between epithelial ocular surface tumors such as OSSN as compared with subepithelial tumors such as conjunctival lymphoma and conjunctival melanoma given their distinctive findings. Read More

Orphanet J Rare Dis 2021 03 23;16(1):147. Epub 2021 Mar 23.

Department of Dermatology and Venereology, Sapienza University of Rome, Policlinico Umberto I, Rome, Italy.

Background: Neurofibromatosis Type I (NF1), also termed von Recklinghausen disease, is a rare genetic disorder that is transmitted by autosomal dominant inheritance, with complete penetrance and variable expressivity. It is caused by mutation in the NF1 gene on chromosome 17 encoding for neurofibromin, a protein with oncosuppressive activity, and it is 50% sporadic or inherited. The disease is characterized by a broad spectrum of clinical manifestations, mainly involving the nervous system, the eye and skin, and a predisposition to develop multiple benign and malignant neoplasms. Read More

Clin Cosmet Investig Dermatol 2021 18;14:65-71. Epub 2021 Jan 18.

Aesthetic Department, Dermatology Hospital, Southern Medical University, Guangzhou, Guangdong 510091, People's Republic of China.

Background: Hori's nevus is a common pigmented disorder on the face, preferentially in females. The clinical features have not been well characterized.

Aim: To characterize the clinical features of Hori's nevus in Chinese adults. Read More

Eye (Lond) 2021 09 16;35(9):2579-2584. Epub 2020 Nov 16.

Department of Ocular Oncology, Moorfields Eye Hospital, City Road, London, EC1V 2PD, UK.

Objective: The objective of this study is to characterise the natural history of conjunctival naevi in a paediatric and adolescent population.

Methods: All children and adolescents referred to Moorfields Ocular Oncology Service for evaluation between January 2015 and 2020 were included. Exclusion criteria included age >20 years old and lack of anterior segment photographs. Read More

Zhonghua Yan Ke Za Zhi 2020 Nov;56(11):846-852

Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Key Laboratory of Ophthalmology & Visual Sciences, Beijing 100730, China.

To report the clinical and pathological features and surgical treatment of the linear nevus sebaceous syndrome. It was a retrospective case series study. The clinical records of 11 patients (14 eyes) who were diagnosed as linear nevus sebaceous syndrome between April 2009 and February 2018 at Beijing Tongren Hospital were analyzed. Read More

Am J Ophthalmol 2021 02 12;222:137-147. Epub 2020 Sep 12.

Department of Ophthalmology, Leiden University Medical Center, Leiden, the Netherlands.

Purpose: To study the feasibility and diagnostic value of vascular imaging using optical coherence tomography (OCT)-angiography (OCTA) of melanocytic lesions of the conjunctiva and iris.

Design: Cross-sectional study.

Methods: Twenty-five patients with an untreated conjunctival lesion (5 melanoma, 13 nevus, 7 primary acquired melanosis [PAM]) and 52 patients with an untreated iris lesion (10 melanoma, 42 nevus) were included. Read More

Nepal J Ophthalmol 2020 Jan;12(23):106-109

Hospital for Children, Eye, ENT and Rehabilitation Services (CHEERS).

Introduction: Ticks are ectoparasites which can lead to various blood borne diseases. Tick bite may resemble pigmented nevi, mole or nodule resulting a diagnostic dilemma. Tick bite in eye lid is rare and this case report describes tick bite in lower eye lid mimicking a traumatized pigmented nodule where the tick was identified only on magnification and was successfully removed mechanically. Read More

Klin Monbl Augenheilkd 2020 Sep 10;237(9):1143-1159. Epub 2020 Aug 10.

The aim of this paper is to give an overview of different benign and malignant epibulbar tumors. Categories can be made of the age of manifestation (paediatric tumors versus tumors of adults), the originating cell types (squamous cell tumors, melanocytic tumors, lymphomas or germ cell tumors) or genesis (proliferative, infectious or degenerating tumors). Most epibulbar tumors show lesions on the conjunctiva or the cornea. Read More

Br J Ophthalmol 2021 06 16;105(6):775-778. Epub 2020 Jul 16.

Ocular Oncology Service, Moorfields Eye Hospital NHS Foundation Trust, London, UK.

Background: Conjunctival melanoma is the second most common conjunctival malignant tumour after squamous cell carcinoma, usually arising from primary acquired melanosis and less commonly from a conjunctival naevus or de novo. We report four cases of conjunctival melanoma masquerading as ocular surface squamous neoplasia.

Methods: Four patients (2 females and 2 males; mean age 60. Read More

Sci Rep 2019 12 3;9(1):18204. Epub 2019 Dec 3.

Department of Ophthalmology, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul, 03080, Korea.

To evaluate histopathological characteristics of conjunctival pigmented lesions and analyze clinical features related to histologic classification in Asian population, we analyzed medical records, anterior segment photographs, and histological specimen of 85 eyes who had undergone biopsy for pigmented conjunctival lesions at Seoul National University Hospital between 1999 and 2018. Compound nevus was the most common type of conjunctival pigmented lesions (67.1%), followed by conjunctival melanocytic intraepithelial neoplasia (primary acquired melanosis)(11. Read More

Zhonghua Yan Ke Za Zhi 2019 Nov;55(11):847-853

Department of Ophthalmology, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China.

To investigate the anatomical region, histopathological classification and histogensis distribution of ocular mass lesions in South China. Retrospective cases study. The clinical and pathological data of 7 910 samples with ocular (adnexal) tumors or proliferative lesions which were examined from January 2000 to May 2018 were retrospectively retrieved. Read More

Graefes Arch Clin Exp Ophthalmol 2019 Aug 16;257(8):1783-1788. Epub 2019 May 16.

Department of Ophthalmology, Leiden University Medical Center, P.O. Box 9600, 2300 RC, Leiden, The Netherlands.

Purpose: In primary conjunctival melanoma (CoM), one of the characteristics that is associated with an increased risk of metastases and death is a lack of tumour pigmentation. The aim of this study was to investigate whether the degree of pigmentation of CoM recurrences relates similarly to clinical outcome.

Methods: A data set of 177 patients with a CoM recurrence from the Wills Eye Hospital (USA) and the Leiden University Medical Center (The Netherlands) was analysed. Read More

Klin Monbl Augenheilkd 2021 Aug 2;238(8):899-900. Epub 2019 May 2.

Klinik für Augenheilkunde, Universitätsklinikum Ulm.

Ann Plast Surg 2019 05;82(5S Suppl 4):S306-S309

Division of Plastic and Reconstructive Surgery, Cedar-Sinai, Los Angeles, CA.

Background: Congenital melanocytic nevi (CMN) have a 1% to 5% lifetime risk for malignant transformation, with 50% of transformations occurring before the age of 5 years.The aim of this study is to assess the risk of melanoma development in pediatric patients with facial CMN involving the eyebrows, eyelid margins, and nasal alae where a margin of CMN was not excised to preserve these structures.

Methods: A retrospective chart review of all pediatric patients with CMN from 1986 to 2014 was performed to review demographic information, diagnosis, and number of surgeries. Read More

Cesk Slov Oftalmol Winter 2018;74(3):92-97

The etiology of papilloma formation is multifactorial. There is a strong association between human papillomavirus (HPV) and the development of these conjunctival lesions. HPV is tumorigenic and commonly produces benign tumors with low malignant potential. Read More

Dermatol Surg 2019 07;45(7):898-905

University of Washington School of Medicine, Spokane, Washington.

Background: Lateral tarsal strip (LTS) and medial spindle (MS) procedures are surgical techniques used to address cicatricial ectropion.

Objective: To evaluate the clinical characteristics and efficacy of simultaneous LTS and MS procedures for repair of cicatricial ectropion occurring after dermatologic surgeries.

Methods: A retrospective review of all cases of symptomatic, cicatricial, lateral, and medial punctal ectropion in 1 author's (C. Read More

Eye (Lond) 2019 05 18;33(5):767-771. Epub 2018 Dec 18.

Jules'Gonin Eye Hospital, University of Lausanne, Lausanne, Switzerland.

Purpose: To report the clinical and histopathologic features of two cases of eyelids metastases from uveal melanoma diagnosed in a metachronous and synchronous fashion.

Methods: Monocentric retrospective case series of histopathologically proven eyelids metastases from uveal melanoma at our institution.

Results: Two patients were presented to our hospital for upper eyelids pigmented and firm lesions. Read More

Toxicol Pathol 2018 10 22;46(7):799-820. Epub 2018 Oct 22.

2 Preclinical Development, Alcon Research Ltd., Fort Worth, Texas, USA.

Information on background changes in the ocular tissues of rabbits ( Oryctolagus cuniculus), a common species employed in ophthalmic toxicology studies, is sparse. This complicates interpretation of changes in light of small sample sizes on any single study. The purpose of this publication is to document the interstudy incidence of spontaneous or iatrogenic changes occurring in eyes of control rabbits. Read More

J Fr Ophtalmol 2018 May;41(5):475-476

Service d'ophtalmologie, hôpital militaire Mohamed V, faculté de médecine et de pharmacie Rabat, université Mohammed V, 10000 Rabat, Maroc.

Ophthalmology 2018 08 15;125(8):1189-1198. Epub 2018 Mar 15.

Bascom Palmer Eye Institute, University of Miami, Miami, Florida. Electronic address:

Purpose: Blue nevus is a melanocytic tumor that is commonly found in the skin. Extracutaneous presentations, including the ocular surface, are rare. As such, the purpose of this study was to characterize the clinical features and clinical course of congenital melanocytic tumor (blue nevus) of the conjunctiva. Read More

PLoS One 2018 14;13(2):e0192908. Epub 2018 Feb 14.

University of Szeged, Department of Ophthalmology, Szeged, Hungary.

Purpose: Conjunctival naevi are the most frequently diagnosed primary melanocytic lesions of the conjunctiva. The clinical manifestations are greatly variable which may result in diagnostic difficulties and differential diagnostic confusions. Therefore aims of the present study were: 1) to assess the morphologic features of conjunctival naevi; 2) to delineate the anterior segment optical coherence tomography (AS-OCT) characteristics of these lesions; 3) to compare AS-OCT and ultrasound biomicroscopy (UBM) as diagnostic tools in these alterations and 4) to correlate histological results with the AS-OCT pictures in case of surgically excised naevi. Read More

Invest Ophthalmol Vis Sci 2018 01;59(1):117-121

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, United States.

Purpose: To evaluate BRAF, NRAS, and GNAQ mutations in surgical specimens of common and blue conjunctival melanocytic nevi.

Methods: Surgical specimens from 25 conjunctival melanocytic nevi (23 common and 2 blue) of 25 patients were evaluated. All common nevi were analyzed immunohistochemically for the expression of BRAF V600E or NRAS Q61R. Read More

Arch Craniofac Surg 2016 Sep 23;17(3):176-179. Epub 2016 Sep 23.

Department of Pathology, Soonchunhyang University Seoul Hospital, Soonchunhyang University College of Medicine, Seoul, Korea.

Primary cutaneous mucinous carcinoma (PCMC) is a rare low-grade malignant neoplasm derived from the eccrine glands. PCMC most commonly arises in the head and neck, with the eyelid being the most common site of origin. This case report describes a 51-year-old male with a painless, pigmented superficial nodular lesion over his right lower eyelid. Read More