93,027 results match your criteria Pigment Cell & Melanoma Research[Journal]
Int J Biol Macromol 2018 Dec 3. Epub 2018 Dec 3.
Department of Biochemistry, Faculty of life sciences, Aligarh Muslim University, Aligarh, UP 202002, India. Electronic address:
Thiol Protease inhibitors (cystatins) are endogenous natural inhibitors of cysteine proteases. They are present in all mammalians cells and body fluids. Cystatin are allocated into three major families. Read More
Hemodial Int 2018 Dec 6. Epub 2018 Dec 6.
Department of Nephrology, Cleveland Clinic Akron General, Akron, Ohio, USA.
Skin manifestations are commonly seen in end stage renal disease (ESRD). Skin involvement in this population can be extensive and dramatically worsen quality of life. Close observation of the skin and nails of ESRD patients by clinicians allows for timely diagnosis and treatment, which ultimately improves quality of life and reduces mortality. Read More
J Eur Acad Dermatol Venereol 2018 Dec 6. Epub 2018 Dec 6.
Dermatology Department. Hospital, Universitario de Alicante. ISABIAL. Miguel Hernandez University. Sant Joan de Alicante, Spain.
Background: A variety of cutaneous smooth muscle neoplasms may arise in the skin and are frequently unrecognized by clinicians. There is sparse data relating to the dermoscopy of piloleiomyiomas (PL) and nothing has been published about the dermoscopy of angioleiomyomas (AL) and leiomyosarcomas (LS).
Objectives: To evaluate the morphological findings of a large series of cutaneous PL, AL and LS under dermoscopic observation, comparing these findings among them. Read More
Zoolog Sci 2018 Dec;35(6):505-513
2 Department of Chemistry, Fujita Health University School of Health Sciences, Toyoake, Aichi 470-1192, Japan.
Pheomelanin-based plumage pigmentation has been suggested to be an honest signal of individual quality to conspecifics. It has been hypothesized that oxidative stress is an important agent linking pheomelanic pigmentation to individual quality. Using the Asian barn swallow Hirundo rustica gutturalis, a wild passerine, we tested whether the pheomelanin pigmentation in the red throat patch of adult males, a sexually selected trait, is associated with the ratio between reduced and oxidized glutathione (RGSH/GSSG) as an indicator of current oxidative balance during the early breeding season. Read More
J Eur Acad Dermatol Venereol 2018 Dec 6. Epub 2018 Dec 6.
Dermatology Clinic - Department of Medical Science and Public Health, University of Cagliari, Via Ospedale 54, 09124, Cagliari, Italy.
Background: The clinical and dermoscopic changes of melanocytic nevi under the effects of photo-epilation are poorly known.
Objective: Prospective study on clinical and dermatoscopic effects of photoepilation on melanocytic nevi.
Methods: Eighteen patients exposed to photo-epilation gave consent to a follow-up program from 2008 to 2017 at the Videodermatoscopic Office of the Dermatology Clinic of Cagliari (Italy), with clinical and dermoscopic assessment. Read More
Transl Vis Sci Technol 2018 Nov 30;7(6):18. Epub 2018 Nov 30.
Carver College of Medicine, Department of Ophthalmology and Visual Sciences, Institute for Vision Research, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA.
Purpose: We correlate optical coherence tomography (OCT) retinal layer thickness measurements with histology in wild-type and retinal degenerative pigs.
Methods: OCT scans were obtained using the Bioptigen Envisu R2200. In normal pigs, three eyes were imaged in vivo, and three eyes were imaged after enucleation. Read More
Clin Cosmet Investig Dermatol 2018 12;11:571-578. Epub 2018 Nov 12.
Innovation and Development, ISDIN SA, Barcelona, Spain,
Background: The effects of pollution on health have received increasing attention in recent years. Extrinsic skin aging occurs via multiple processes, and pollution is now recognized as a major component, causing increased pigmentation and wrinkles via oxidative mechanisms. We tested the antipollution efficacy of a cosmetic facial cream (FC) by assessing its effects on carbon particle adhesion to skin and on oxidative and inflammatory pathways in the skin. Read More
Sci Rep 2018 Dec 5;8(1):17660. Epub 2018 Dec 5.
Advanced Photonics Research Institute, Gwangju Institute of Science and Technology, Gwangju, 61005, South Korea.
Optical coherence tomography (OCT) is a noninvasive imaging modality that can provide high-resolution, cross-sectional images of tissues. Especially in retinal imaging, OCT has become one of the most valuable imaging tools for diagnosing eye diseases. Considering the scattering and absorption properties of the eye, the 1000-nm OCT system is preferred for retinal imaging. Read More
Nature 2018 Dec 5. Epub 2018 Dec 5.
Department of Geology, Lund University, Lund, Sweden.
Ichthyosaurs are extinct marine reptiles that display a notable external similarity to modern toothed whales. Here we show that this resemblance is more than skin deep. We apply a multidisciplinary experimental approach to characterize the cellular and molecular composition of integumental tissues in an exceptionally preserved specimen of the Early Jurassic ichthyosaur Stenopterygius. Read More
Microbiome 2018 Dec 5;6(1):216. Epub 2018 Dec 5.
Univ Lyon, Université Claude Bernard Lyon 1, CNRS, INRA, VetAgro Sup, UMR5557/1418 Ecologie Microbienne, 69622, Villeurbanne, France.
Background: The World-famous UNESCO heritage from the Paleolithic human society, Lascaux Cave (France), has endeavored intense microclimatic perturbations, in part due to high touristic pressure. These perturbations have resulted in numerous disturbances of the cave ecosystem, including on its microbial compartment, which resulted in the formation of black stains especially on the rock faces of the passage. We investigated the cave microbiome in this part of Lascaux by sampling three mineral substrates (soil, banks, and inclined planes) on and outside stains to assess current cave microbial assemblage and explore the possibility that pigmented microorganisms involved in stain development occur as microbial consortia. Read More
BMC Plant Biol 2018 Dec 5;18(1):331. Epub 2018 Dec 5.
Iwate Biotechnology Research Center, 22-174-4, Narita, Kitakami, Iwate, 024-0003, Japan.
Background: CRISPR/Cas9 technology is one of the most powerful and useful tools for genome editing in various living organisms. In higher plants, the system has been widely exploited not only for basic research, such as gene functional analysis, but also for applied research such as crop breeding. Although the CRISPR/Cas9 system has been used to induce mutations in genes involved in various plant developmental processes, few studies have been performed to modify the color of ornamental flowers. Read More
Toxicol Ind Health 2018 Dec 5:748233718807046. Epub 2018 Dec 5.
2 Department of Animal Biology, School of life Sciences, University of Hyderabad, Telangana, India.
Evaluation of the toxic effects of a widely used synthetic pyrethroid, deltamethrin (DM), was carried out in this study. This pesticide is preferred for pest control because of its low environmental persistence and toxicity. We investigated the expression pattern of four genes, namely, you ( you), yot ( you-too), momo ( mom) and ubo ( u-boot) during early development of zebrafish, that is, from 12 hpf to 48 hpf stages. Read More
J Invest Dermatol 2018 Nov 30. Epub 2018 Nov 30.
Center for Dermatoepidemiology, Veterans Affairs Medical Center, Providence, Rhode Island, USA; Department of Dermatology, Alpert Medical School of Brown University, Providence, Rhode Island, USA.
ACS Appl Mater Interfaces 2018 Dec 3. Epub 2018 Dec 3.
Department of Chemistry and Chemical Biology , Northeastern University , Boston , Massachusetts 02115 , United States.
Color is a signature visual feature in nature; however, the ability to trigger color change in the presence of different environmental stimuli is unique to only a handful of species in the animal kingdom. We exploit the natural color-changing properties of the predominant pigment in arthropods and cephalopods-xanthommatin (Xa)-and describe its utility as a new broad-spectrum electrochromic material. To accomplish this goal, we explored the spectroelectrochemical properties of Xa adsorbed to an indium-doped tin oxide-coated substrate chemically modified with poly(3,4-ethylene dioxythiophene) doped with poly(styrenesulfonate) (PEDOT:PSS). Read More
J Zhejiang Univ Sci B 2018 Dec.;19(12):895-909
Eye Center, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China.
Objective: This paper applied a transcriptomic approach to investigate the mechanisms of adriamycin (ADR) in treating proliferative vitreoretinopathy (PVR) using ARPE-19 cells.
Methods: The growth inhibitory effects of ADR on ARPE-19 cells were assessed by sulforhodamine B (SRB) assay and propidium iodide (PI) staining using flow cytometry. The differentially expressed genes between ADR-treated ARPE-19 cells and normal ARPE-19 cells and the signaling pathways involved were investigated by microarray analysis. Read More
Pigment Cell Melanoma Res 2018 Dec 2. Epub 2018 Dec 2.
Department of Dermatology and Allergy, University Hospital, LMU Munich, Frauenlobstr. 9-11, 80337, Munich, Germany.
The transcription factor sex determining region Y-box 10 (SOX10) plays a key role in the development of melanocytes and glial cells from neural crest precursors. SOX10 is involved in melanoma initiation, proliferation, invasion, and survival. However, specific mediators which impart its oncogenic properties remain widely unknown. Read More
Pigment Cell Melanoma Res 2018 Dec 2. Epub 2018 Dec 2.
Department of Dermatology, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012, India.
Most of the cancer types in general and melanoma in particular exhibit mitochondrial dysfunction leading to the Warburg effect. Our present study stemmed from the observation that human melanoma A-375 and B16 cells displayed overexpression of a novel micro-RNA, miR-2909, shown in our earlier studies to be involved in aerobic glycolysis. Consequently, our study attempts to demonstrate the role of miR-2909 in the regulation of mitochondrial function within human melanocytes. Read More
Exp Dermatol 2018 Dec 2. Epub 2018 Dec 2.
Department of Molecular Biology, Princeton University, Princeton, NJ, 08544.
Mammalian periodic pigment patterns, such as spots and stripes, have long interested mathematicians and biologists because they arise from nonrandom developmental processes that are programmed to be spatially constrained, and can therefore be used as a model to understand how organized morphological structures develop. Despite such interest, the developmental and molecular processes underlying their formation remain poorly understood. Here, we argue that Arvicanthines, a clade of African rodents that naturally evolved a remarkable array of coat patterns, represent a tractable model system in which to dissect the mechanistic basis of pigment pattern formation. Read More
Pigment Cell Melanoma Res 2018 Dec 1. Epub 2018 Dec 1.
Institute of Pathology, First Faculty of Medicine, Charles University and General University Hospital in Prague, Czech Republic.
The objective of our study is a comparison of five different scoring methods of tumor infiltrating lymphocytes (TILs) assessment in a group of 213 cases of superficial spreading and nodular melanoma. The scoring methods include i) Clark scoring; ii) Melanoma Institute Australia system; iii) scoring system used in the study of Saldanha et al.; iv) scoring system used in the TCGA study and modified by Park et al. Read More
Pigment Cell Melanoma Res 2018 Dec 1. Epub 2018 Dec 1.
Unilever R&D, 40 Merritt Blvd, Trumbull, CT, 06611.
Melasma is a skin disorder characterized by hyperpigmented patches due to increased melanin production and deposition. In this pilot study we evaluate the potential of multiphoton microscopy (MPM) to characterize non-invasively the melanin content, location, and distribution in melasma and assess the elastosis severity. We employed a clinical MPM tomograph to image in-vivo morphological features in melasma lesions and adjacent normal skin in 12 patients. Read More
Naunyn Schmiedebergs Arch Pharmacol 2018 Nov 30. Epub 2018 Nov 30.
Department of Cardiology, Tangdu Hospital, Air Force Military Medical University, Xinsi Road, Xi'an, 710000, China.
Coronary microembolization (CME) caused by physical obstruction in coronary microcirculation induces myocardial apoptosis and cardiac dysfunction, and it was reported that the inactivation of the Nrf2/HO-1 signaling was involved in this process. Astaxanthin (AST) is a reddish pigment that belongs to keto-carotenoids. It is also a potent antioxidant and has been reported to activate Nrf2/HO-1 signaling in vein endothelial cells. Read More
J Mater Sci Mater Med 2018 Nov 30;29(12):181. Epub 2018 Nov 30.
Department of Women's and Reproductive Health, Oxford University, Oxford, Oxfordshire, UK.
Dysregulation of iron metabolism is a common characteristic of cancer cells. The rapid proliferation of the tumour cells means that there is an increased dependence upon iron compared to healthy cells. Chelation of iron can be undertaken with a number of different compounds, however, simply lowering systemic iron levels to control tumour growth is not possible since iron is essential for cellular metabolism in the rest of the body. Read More
Ophthalmol Retina 2018 Oct 2;2(10):1021-1027. Epub 2018 Jun 2.
Division of Epidemiology and Clinical Applications, National Eye Institute, Bethesda, Maryland.
Purpose: To identify the development and progression of macular retinal pigment epithelial atrophy in eyes with neovascular (CNV) age-related macular degeneration (AMD) and to correlate with visual acuity (VA).
Design: Cohort study.
Participants: Age-Related Eye Disease Study 2 (AREDS2) participants with intermediate AMD enrolled in a randomized controlled clinical trial of oral supplements. Read More
Rom J Ophthalmol 2018 Jul-Sep;62(3):222-227
Ophthalmology Department, Bucharest University Emergency Hospital, Bucharest, Romania.
To present a series of 2 cases of central serous chorioretinopathy and the changes in the macular pigment optical density during the evolution of the disease. A 32-year-old patient presented himself for blurred vision on his LE. The SD OCT imaging revealed serous macular detachment of the neurosensory retina on the LE. Read More
Rom J Ophthalmol 2018 Jul-Sep;62(3):217-221
Anatomy Department, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
Serpiginous choroiditis represents an inflammation, often asymmetric, situated at the level of the inner choroid, which is related to the retinal pigment epithelium and the choriocapillaris. It is known as a primarily idiopathic, but there are authors who consider it an autoimmune process. Many times, fundus autofluorescence is the investigation which is guiding the diagnosis, the management, also the follow-up together with the determination of the progressive visual prognosis. Read More
Rom J Ophthalmol 2018 Jul-Sep;62(3):183-187
Anatomy Department, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
White dot syndromes consists a group of inflammatory eye diseases with an unknown etiology involving the external retina, retinal pigment epithelium, choroid or combinations of them. They affect one or both eyes, at the same time or not. White dot syndromes are often self-limited, with a variable prognosis, depending on the type of the disease. Read More
Indian Dermatol Online J 2018 Nov-Dec;9(6):467-468
Department of Pathology, AIIMS, Jodhpur, Rajasthan, India.
Saudi J Biol Sci 2018 Nov 6;25(7):1411-1419. Epub 2015 Nov 6.
Genome Research Chair, Dept of Biochemistry, College of Science, King Saud University, Riyadh 11451, Saudi Arabia.
Halophilic microbes are studied to understand the metabolic pathways adopted by organisms in such extreme environment and for their biotechnological exploitation. In thallosohaline environments worldwide, the autotrophic alga Teodoresco is omnipresent, but it is being recently realised that the heterotrophic components vary in different regions. The unexplored eastern coastline of India abutted by Bay of Bengal was investigated for the heterotrophic halophilic microbes in this region. Read More
Saudi J Biol Sci 2018 Nov 3;25(7):1393-1401. Epub 2016 Oct 3.
Department of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
The effects of magnesium (Mg) supplementation on the growth performance, oxidative damage, DNA damage, and photosynthetic pigment synthesis, as well as on the activity level of carbonic anhydrase (CA), ribulose-1,5-bisphosphate carboxylase (Rubisco), and antioxidant enzymes were studied in L. plants exposed to heat stress (HS) and non-heat-stress (non-HS) conditions. Seeds were grown in pots containing a 1:1 mixture of sand and peat, with Mg treatments. Read More
Saudi J Biol Sci 2018 Nov 12;25(7):1339-1347. Epub 2016 Feb 12.
Department of Botany and Microbiology, Faculty of Science, Alexandria University, Alexandria, Egypt.
Germination bioassay was carried out to test the biological activity of L. (ASAE), Del. (AMAE), L. Read More
Oman J Ophthalmol 2018 Sep-Dec;11(3):294-296
Department of Ophthalmology, Government Medical College, Srinagar, Jammu and Kashmir, India.
The purpose of this study was to present the surgical outcome in optic disc pit associated maculopathy in a patient who was treated with vitrectomy, internal limiting membrane (ILM) peeling, barrage laser photocoagulation, and silicone oil tamponade. A 21-year-old Indian male was diagnosed with optic disc pit maculopathy in his left eye with a best-corrected visual acuity (BCVA) of 20/200. A 23-gauge pars plana vitrectomy with peeling of ILM was done using brilliant blue dye. Read More
J Prosthet Dent 2018 Nov 30. Epub 2018 Nov 30.
Professor, Department of Chemical Engineering and Department of Bioengineering, University of Illinois at Chicago, Chicago, Ill. Electronic address:
Statement Of Problem: Maxillofacial prostheses made of silicone elastomers undergo undesirable color degradation over time. How this color change can be prevented is unclear.
Purpose: The purpose of this in vitro study was to evaluate the ability of an oxide nanocoating to prevent color degradation of maxillofacial silicone elastomers after artificial accelerated aging. Read More
Free Radic Biol Med 2018 Nov 28. Epub 2018 Nov 28.
Laboratory of Retinal Neurochemistry and Experimental Ophthalmology, Department of Human Biochemistry, School of Medicine/CEFyBO, University of Buenos Aires/CONICET, Buenos Aires, Argentina. Electronic address:
Non-exudative age-related macular degeneration (NE-AMD) represents the leading cause of blindness in the elderly. The macular retinal pigment epithelium (RPE) lies in a high oxidative environment because its high metabolic demand, mitochondria concentration, reactive oxygen species levels, and macular blood flow. It has been suggested that oxidative stress-induced damage to the RPE plays a key role in NE-AMD pathogenesis. Read More
Dev Biol 2018 Nov 28. Epub 2018 Nov 28.
Institute for Integrative Neurobiology and Department of Biology, Faculty of Science and Engineering, Konan University, Kobe 658-8501, Japan. Electronic address:
The ascidian larva has a pigmented ocellus comprised of a cup-shaped array of approximately 30 photoreceptor cells, a pigment cell, and three lens cells. Morphological, physiological and molecular evidence has suggested evolutionary kinship between the ascidian larval photoreceptors and vertebrate retinal and/or pineal photoreceptors. Rx, an essential factor for vertebrate photoreceptor development, has also been suggested to be involved in the development of the ascidian photoreceptor cells, but a recent revision of the photoreceptor cell lineage raised a crucial discrepancy between the reported expression patterns of Rx and the cell lineage. Read More
Food Chem 2019 Mar 31;277:744-752. Epub 2018 Oct 31.
Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China; National Engineering Research Center for Fruit and Vegetable Processing, Beijing 100083, China. Electronic address:
This study investigated an efficient and recyclable approach for purification of crude pumpkin oligosaccharide (POS) by macroporous resins. Five resins with different physical and chemical properties were tested for decoloration of POS. In virtue of its higher decoloration ratio (92. Read More
Food Chem 2019 Mar 2;277:533-542. Epub 2018 Nov 2.
College of Life Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China. Electronic address:
In this study, solid-state fermentation was used to produce Inonotus hispidus melanin (IH melanin). Its physicochemical properties were characterized, and ultrasonic-assisted extraction was used to optimize its extraction process. Characterization techniques like elemental analysis and so on were used to identify melanin. Read More
Food Chem 2019 Mar 25;277:438-447. Epub 2018 Oct 25.
Centre de Développement Bioalimentaire du Québec, La Pocatière, QC G0R 1Z0, Canada; Department of Food Science, Université Laval, Québec, QC G1V 0A6, Canada; Department of Science, Université Sainte-Anne, 1695 Rd 1, Church Point, NS B0W 1M0, Canada. Electronic address:
The impact of different factors (must protein treatment: bentonite and heat; pomace: fermented with and without; tannin addition: 0-9 g/L; and time of maceration: 0-11 days) on tannin, pigment, and protein extraction/retention in Frontenac wines was investigated. Wine tannin concentration and composition were determined by HPLC-fluorescence. Protein and pigment parameters were analysed by BCA assay and Boulton's method, respectively, using UV-spectrophotometry. Read More
Food Chem 2019 Mar 17;277:391-397. Epub 2018 Oct 17.
Facultad de Agronomía, Universidad de la República, Avda. Garzón 780. C.P., 12900 Montevideo, Uruguay.
The purpose of this investigation was to assess the grape pigment extraction during red-winemaking. The pigment content and profile of skin, wines and pomace of Vitis vinifera grapes with different pigment profiles Syrah, Marselan and Tannat was thoroughly studied. The p-coumaroylated anthocyanin proportions were 37% in pomace, compared to 19% in skins and just 5% in wines, highlighting their poor extraction. Read More
J Oncol Pharm Pract 2018 Nov 30:1078155218815557. Epub 2018 Nov 30.
Department of Pediatrics, School of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan.
Ann Plast Surg 2018 Dec 3. Epub 2018 Dec 3.
Division of Plastic and Reconstructive Surgery, Department of Surgery, Tri-Service General Hospital, National Defense Medical Center.
The pigment melanin is produced by melanocytes, is primarily responsible for skin color, and protects it against ultraviolet rays that can cause the destruction of genetic material within the keratinocytes. To elucidate the mechanisms of many diseases associated with melanocytes, such as melanoma and albinism, or burns with uneven pigment distribution, the disease model needs to be established first. In this study, we aimed to construct the melanocyte model from patients in a short period. Read More
Front Plant Sci 2018 20;9:1699. Epub 2018 Nov 20.
Institute for Molecular Biology and Genetics, Chonbuk National University, Jeonju, South Korea.
We have reported 15 agarose gel band patterns of double-stranded RNA (dsRNA) from spp. We describe herein that band pattern IX in NFCF319, which appeared to be a single band but consisted of two dsRNAs of similar size, was identified as a novel mycovirus, designated partitivirus 1 (ThPV1). The larger segment (dsRNA1) of the ThPV1 genome comprised 2,289 bp and contained a single open reading frame (ORF) encoding an RNA-dependent RNA polymerase (RdRp). Read More
Front Plant Sci 2018 20;9:1687. Epub 2018 Nov 20.
National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest of China, Key Laboratory of the Ministry of Education for Medicinal Resources and Natural Pharmaceutical Chemistry, Shaanxi Normal University, Xi'an, China.
Phenolic acids from have drawn considerable attention in recent years because of their remarkable pharmacological activities. We previously reported that transcription factor production of anthocyanin pigment 1 (AtPAP1) has strong capability to promote the production of phenolic acids in . However, the responsible molecular mechanism is unclear. Read More
Genetics 2018 Dec 4. Epub 2018 Dec 4.
University of Toronto
G protein-coupled receptors (GPCRs) are crucial sensors of extracellular signals in eukaryotes, with multiple GPCR mutations linked to human diseases. With the growing number of sequenced human genomes, determining the pathogenicity of a mutation is challenging, but can be aided by a direct measurement of GPCR-mediated signaling. This is particularly difficult for the visual pigment rhodopsin, a GPCR activated by light, for which hundreds of mutations have been linked to inherited degenerative retinal diseases such as retinitis pigmentosa (RP). Read More
J Dermatol Sci 2018 Nov 8. Epub 2018 Nov 8.
Department of Tissue and Organ Development, Regeneration and Advanced Medical Science, Gifu University Graduate School of Medicine, Gifu 5011194, Japan. Electronic address:
Syst Appl Microbiol 2018 Nov 20. Epub 2018 Nov 20.
Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, INF 364, 69120 Heidelberg, Germany. Electronic address:
Although birds are hosts to a large number of microorganisms, microbes have rarely been found in avian oil glands. Here, we report on two strains of a new bacterial species from the preen oil of American barn owls (Tyto furcata). Phenotypic as well as genotypic methods placed the isolates to the genus Kocuria. Read More
Nutrients 2018 Dec 2;10(12). Epub 2018 Dec 2.
Instituto Universitario Fernández-Vega (Fundación de Investigación Oftalmológica, Universidad de Oviedo), 33012 Oviedo, Spain.
Oxidative stress affects all the structures of the human eye, particularly the retina and its retinal pigment epithelium (RPE). The RPE limits oxidative damage by several protective mechanisms, including the non-enzymatic antioxidant system zinc-metallothionein (Zn-MT). This work aimed to investigate the role of Zn-MT in the protection of RPE from the oxidative damage of reactive oxygen intermediates by analytical and biochemical-based techniques. Read More
J Photochem Photobiol B 2018 Nov 19;190:110-117. Epub 2018 Nov 19.
Department of Chemistry, Princeton University, Washington Road, Princeton, NJ 08540, United States. Electronic address:
The attribution of quantum beats observed in the time-resolved spectroscopy of photosynthetic light-harvesting antennae to nontrivial quantum coherences has sparked a flurry of research activity beginning a decade ago. Even though investigations into the functional aspects of photosynthetic light-harvesting were supported by X-ray crystal structures, the non-covalent interactions between pigments and their local protein environment that drive such function has yet to be comprehensively explored. Using symmetry-adapted perturbation theory (SAPT), we have comprehensively determined the magnitude and compositions of these non-covalent interactions involving light-harvesting chromophores in two quintessential photosynthetic pigment-protein complexes - peridinin chlorophyll-a protein (PCP) from dinoflagellate Amphidinium carterae and phycocyanin 645 (PC645) from cryptophyte Chroomonas mesostigmatica. Read More
Invest Ophthalmol Vis Sci 2018 Dec;59(15):5705-5716
Department of Ophthalmology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States.
Purpose: To characterize in vivo morphometry and multispectral autofluorescence of the retinal pigment epithelial (RPE) cell mosaic and its relationship to cone cell topography across the macula.
Methods: RPE cell morphometrics were computed in regularly spaced regions of interest (ROIs) from contiguous short-wavelength autofluorescence (SWAF) and photoreceptor reflectance images collected across the macula in one eye of 10 normal participants (23-65 years) by using adaptive optics scanning light ophthalmoscopy (AOSLO). Infrared autofluorescence (IRAF) images of the RPE were collected with AOSLO in seven normal participants (22-65 years), with participant overlap, and compared to SWAF quantitatively and qualitatively. Read More