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    Comparison of Palivizumab Like Antibody Binding to Different Conformations of the RSV F Protein in RSV Infected Adult Hematopoietic Cell Transplant Recipients.
    J Infect Dis 2018 Jan 22. Epub 2018 Jan 22.
    Department of Molecular Virology & Microbiology, Baylor College of Medicine, Houston, TX, USA.
    Background: Most RSV vaccine candidates include fusion (F) protein in different conformations. Antigenic site II found in the different F conformations is the target of palivizumab, the only FDA approved monoclonal antibody (mAb). Serum palivizumab-like antibody (PLA) is a potential serologic correlate of immunity. Read More

    Long-term pubic dermatitis diagnosed as white piedra.
    Cutis 2017 Dec;100(6):448-450
    Premier Dermatology, Abilene, Texas, USA.
    The case of a 58-year-old man with a pruritic rash involving the pubic area that had been undiagnosed for 30 years is presented. At least 15 different primary care physicians and dermatologists evaluated the patient during this time period. Multiple treatments were unsuccessful and a definitive diagnosis was not rendered. Read More

    Establishing Correlates of Protection for Vaccine Development: Considerations for the Respiratory Syncytial Virus Vaccine Field.
    Viral Immunol 2018 Jan 16. Epub 2018 Jan 16.
    6 Department of Molecular Virology and Microbiology, Baylor College of Medicine , Houston, Texas.
    Correlates of protection (CoPs) can play a significant role in vaccine development by assisting the selection of vaccine candidates for clinical trials, supporting clinical trial design and implementation, and simplifying tests of vaccine modifications. Because of this important role in vaccine development, it is essential that CoPs be defined by well-designed immunogenicity and efficacy studies, with attention paid to benefits and limitations. The respiratory syncytial virus (RSV) field is unique in that a great deal of information about the humoral response is available from basic research and clinical studies. Read More

    The association between anterior nares and nasopharyngeal microbiota in infants hospitalized for bronchiolitis.
    Microbiome 2018 Jan 3;6(1). Epub 2018 Jan 3.
    Department of Medicine, Boston Children's Hospital, Boston, MA, USA.
    Background: The airway microbiome is a subject of great interest for the study of respiratory disease. Anterior nare samples are more accessible than samples from deeper within the nasopharynx. However, the correlation between the microbiota found in the anterior nares and the microbiota found within the nasopharynx is unknown. Read More

    Respiratory syncytial virus and rhinovirus bronchiolitis are associated with distinct metabolic pathways.
    J Infect Dis 2017 Dec 25. Epub 2017 Dec 25.
    Department of Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA.
    Background: Bronchiolitis, the leading cause of US infant hospitalizations, is most commonly caused by respiratory syncytial virus (RSV) followed by rhinovirus (RV). Conventional perception is that bronchiolitis is a single entity, albeit with different viral etiologies and degrees of severity.

    Methods: We conducted a cross-sectional study of nasopharyngeal aspirates from 106 infants hospitalized with either RSV-only (n=80) or RV-only (n=26) bronchiolitis. Read More

    RSV vs. rhinovirus bronchiolitis: difference in nasal airway microRNA profiles and NFκB signaling.
    Pediatr Res 2018 Jan 17. Epub 2018 Jan 17.
    Division of Emergency Medicine, Children's National Health System, Washington, DC.
    BackgroundAlthough rhinovirus infection is associated with increased risks of acute and chronic respiratory outcomes during childhood compared with respiratory syncytial virus (RSV), the underlying mechanisms remain unclear. We aimed to determine the differences in nasal airway microRNA profiles and their downstream effects between infants with rhinovirus and RSV bronchiolitis.MethodsAs part of a multicenter cohort study of infants hospitalized for bronchiolitis, we examined nasal samples obtained from 16 infants with rhinovirus and 16 infants with RSV. Read More

    White piedra, black piedra, tinea versicolor, and tinea nigra: contribution to the diagnosis of superficial mycosis.
    An Bras Dermatol 2017 May-Jun;92(3):413-416
    Dermatology Clinic, Hospital da Irmandade da Santa Casa de Misericórdia de São Paulo - São Paulo (SP) Brazil.
    Superficial mycoses are fungal infections restricted to the stratum corneum and to the hair shafts, with no penetration in the epidermis; they are: white piedra, black piedra, tinea versicolor, and tinea nigra. This study presents images of mycological tests performed in the laboratory, as well as exams performed at the authors office, in order to improve the dermatologist's knowledge about the diagnosis of these dermatoses, which are common in many countries. Read More

    Analysis of the influence of the T393C polymorphism of the GNAS gene on the clinical expression of primary hyperparathyroidism.
    Endocrinol Diabetes Nutr 2017 Dec 18;64(10):524-530. Epub 2017 Oct 18.
    Servicio de Endocrinología, Hospital Universitario "Marqués de Valdecilla", Instituto de Investigación "Marqués de Valdecilla" (IDIVAL), Universidad de Cantabria, Avda. de Valdecilla s/n, Santander 39008, Cantabria, Spain.
    Background: The receptor of parathyroid hormone and parathyroid hormone-related-protein (PTH/PTHrp) is located in the cell membrane of target tissues - kidney and osteoblasts. It is a G protein-coupled-receptor whose Gα subunit is encoded by the GNAS gene. Our aim was to study whether the single nucleotide polymorphism (SNP) T393C of the GNAS gene is associated with renal stones, bone mineral density (BMD), or bone remodelling markers in primary hyperparathyroidism (PHPT). Read More

    Effects of Cyclosporine, Tacrolimus, and Rapamycin on Osteoblasts.
    Transplant Proc 2017 Nov;49(9):2219-2224
    Bioquímica Investigación, Instituto de Investigación Sanitaria Fundación Jiménez Díaz, Madrid, Spain. Electronic address:
    Purpose: One factor that can contribute to severe bone loss after transplantation is the direct action of immunosuppressants on bone cells. The aim of this work was to study the effects of cyclosporine (CsA), tacrolimus (FK-506), and rapamycin (RAPA) on the release of three local factors directly implicated in bone-remodeling regulation and apoptosis of human osteoblasts: interleukin (IL)-6, osteoprotegerin, and receptor activator of nuclear factor κβ (RANKL).

    Basic Procedures: Human osteoblasts were obtained from five different patients who underwent orthopedic surgery. Read More

    Respiratory Syncytial Virus Genotypes, Host Immune Profiles, and Disease Severity in Young Children Hospitalized With Bronchiolitis.
    J Infect Dis 2017 Dec;217(1):24-34
    Center for Vaccines and Immunity, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio.
    Background: Data on how respiratory syncytial virus (RSV) genotypes influence disease severity and host immune responses is limited. Here, we characterized the genetic variability of RSV during 5 seasons, and evaluated the role of RSV subtypes, genotypes, and viral loads in disease severity and host transcriptional profiles.

    Methods: A prospective, observational study was carried out, including a convenience sample of healthy infants hospitalized with RSV bronchiolitis. Read More

    Listening to Relaxing Music Improves Physiological Responses in Premature Infants: A Randomized Controlled Trial.
    Adv Neonatal Care 2018 Feb;18(1):58-69
    Mind, Brain, and Behavior Research Center (CIMCYC), University of Granada, Granada, Spain (Mr Caparros-Gonzalez, Dr Diaz-Piedra, and Dr Buela-Casal); Faculty of Psychology, University of Balearic Islands, Balearic Islands, Spain (Mr de la Torre-Luque); School of Computer Science, University of Malaga, Malaga, Spain (Dr Vico); and Gynecology and Obstetric Department, Hospital Poniente, El Ejido, Almeria, Spain (Mr Caparros-Gonzalez).
    Background: Premature infants are exposed to high levels of noise in the neonatal intensive care unit (NICU).

    Purpose: This study evaluated the effect of a relaxing music therapy intervention composed by artificial intelligence on respiratory rate, systolic and diastolic blood pressure, and heart rate.

    Methods: A double-blind, randomized, controlled trial was conducted in the NICUs of 2 general public hospitals in Andalusia, Spain. Read More

    Debates in Allergy Medicine: Allergy skin testing cannot be replaced by molecular diagnosis in the near future.
    World Allergy Organ J 2017 19;10(1):32. Epub 2017 Sep 19.
    Institute of Medical Statistics and Epidemiology, Faculty of Medicine, University of Cologne, Cologne, Germany.
    Percutaneous skin prick tests (SPT) have been considered the preferred method for confirming IgE-mediated sensitization. This reliable and minimally invasive technique correlates with in vivo challenges, has good reproducibility, is easily quantified, and allows analyzing multiple allergens simultaneously. Potent extracts and a proficient tester improve its accuracy. Read More

    Flamingos and drought as drivers of nutrients and microbial dynamics in a saline lake.
    Sci Rep 2017 Sep 22;7(1):12173. Epub 2017 Sep 22.
    Departamento de Ecología e Instituto del Agua, Universidad de Granada, 18071, Granada, Spain.
    Waterbird aggregations and droughts affect nutrient and microbial dynamics in wetlands. We analysed the effects of high densities of flamingos on nutrients and microbial dynamics in a saline lake during a wet and a dry hydrological year, and explored the effects of guano on prokaryotic growth. Concentrations of dissolved organic carbon, total phosphorus and total nitrogen in the surface waters were 2-3 fold higher during the drought and were correlated with salinity. Read More

    Immunologic Profiling of Human Metapneumovirus for the Development of Targeted Immunotherapy.
    J Infect Dis 2017 Sep;216(6):678-687
    Center for Cell and Gene Therapy, Baylor College of Medicine, Texas Children's Hospital, and Houston Methodist Hospital.
    Human metapneumovirus (hMPV) is a respiratory virus detected in ≥9% of allogeneic hematopoietic stem cell transplant (HSCT) recipients, in whom it can cause significant morbidity and mortality. Given the lack of effective antivirals, we investigated the potential for immunotherapeutic intervention, using adoptively transferred T cells. Thus, we characterized the cellular immune response to the virus and identified F, N, M2-1, M, and P as immunodominant target antigens. Read More

    Changes in Radial Artery Pulse Pressure During a Fluid Challenge Cannot Assess Fluid Responsiveness in Patients With Septic Shock.
    J Intensive Care Med 2017 Jan 1:885066617732291. Epub 2017 Jan 1.
    1 Department of Critical Care Medicine, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Vasco de Quiroga 15, Mexico City, Mexico.
    Background: Arterial blood pressure is the most common variable used to assess the response to a fluid challenge in routine clinical practice. The aim of this study was to evaluate the accuracy of the change in the radial artery pulse pressure (rPP) to detect the change in cardiac output after a fluid challenge in patients with septic shock.

    Methods: Prospective observational study including 35 patients with septic shock in which rPP and cardiac output were measured before and after a fluid challenge with 400 mL of crystalloid solution. Read More

    Identifying Gaps in Respiratory Syncytial Virus Disease Epidemiology in the United States Prior to the Introduction of Vaccines.
    Clin Infect Dis 2017 Sep;65(6):1020-1025
    Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.
    Respiratory syncytial virus (RSV) causes lower respiratory tract illness frequently. No effective antivirals or vaccines for RSV are approved for use in the United States; however, there are at least 50 vaccines and monoclonal antibody products in development, with those targeting older adults and pregnant women (to protect young infants) in phase 2 and 3 clinical trials. Unanswered questions regarding RSV epidemiology need to be identified and addressed prior to RSV vaccine introduction to guide the measurement of impact and future recommendations. Read More

    Stigma-Stop: A Serious Game against the Stigma toward Mental Health in Educational Settings.
    Front Psychol 2017 21;8:1385. Epub 2017 Aug 21.
    Department of Education, University of AlmeríaAlmería, Spain.
    This paper presents the results from the application of a serious game called Stigma-Stop among a group of high school students with the aim of reducing the stigma toward mental illnesses. The video game features characters with various mental disorders (schizophrenia, depression, bipolar disorder, and panic disorder with agoraphobia) and provides information about these problems. Additionally, the game asks players about whether they have ever felt the same as the characters, if they believe the characters are psychologically well, and if they think they could help these individuals. Read More

    Annual killifish adaptations to ephemeral environments: Diapause i in two austrolebias species.
    Dev Dyn 2017 Nov 18;246(11):848-857. Epub 2017 Sep 18.
    Independent researcher, Viña del Mar, Chile.
    Background: Many organisms are able to survive in extreme environments by entering a state of dormancy. In dormancy, vital activities are reduced until environmental conditions are compatible with active life. Annual killifishes show a special developmental pattern characterized by a phase of dispersion-reaggregation of the blastomeres that separates epiboly from organogenesis, and the capability to enter dormancy in diapause. Read More

    Apex Predators, Rockshelters, and Zoonoses in the Patagonian Holocene.
    J Parasitol 2017 Dec 7;103(6):791-794. Epub 2017 Aug 7.
    Laboratorio de Parasitología de Sitios Arqueológicos. CONICET-Depto. de Biología, FCEyN, Universidad Nacional de Mar del Plata, Calle Funes 3350, Mar del Plata (7600), Argentina.
    Carnivorous mammals are a trophic guild with an important role in the dissemination of parasite infective stages (larvae, eggs, cysts, and oocysts). In the present study, new samples of coprolites attributed to carnivorous mammals, obtained from 2 archaeological caves, were analyzed for the presence of parasites with the aim to increase the knowledge about parasites in rockshelters that could have spread to humans and other mammals. To this purpose, fragments of 3 coprolites from Cerro Casa de Piedra, cave 5 and cave 7, were examined. Read More

    Multicenter Observational Study of the Use of Nebulized Hypertonic Saline to Treat Children Hospitalized for Bronchiolitis From 2008 to 2014.
    Hosp Pediatr 2017 Jul 31. Epub 2017 Jul 31.
    Department of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts; and.
    Objectives: Among children hospitalized for bronchiolitis, we examined temporal trends in the use of hypertonic saline (HTS) and the characteristics associated with receiving this treatment.

    Methods: We conducted a secondary analysis of data from 2 large, multicenter prospective cohort studies that included young children hospitalized with bronchiolitis during 5 winter seasons (2008-2014). Our outcome was receipt of HTS any time during the preadmission visit or hospitalization. Read More

    A Phase 2 randomized, observer-blind, placebo-controlled, dose-ranging trial of aluminum-adjuvanted respiratory syncytial virus F particle vaccine formulations in healthy women of childbearing age.
    Vaccine 2017 Jun 1;35(30):3749-3759. Epub 2017 Jun 1.
    Novavax, Inc., 20 Firstfield Road, Gaithersburg, MD 20878, USA. Electronic address:
    Objective: Respiratory syncytial virus (RSV) causes significant morbidity and mortality in infants. We are developing an RSV fusion (F) protein nanoparticle vaccine for immunization of third trimester pregnant women to passively protect infants through transfer of RSV-specific maternal antibodies. The present trial was performed to assess the immunogenicity and safety of several formulations of RSV F vaccine in 1-dose or 2-dose schedules. Read More

    [Hip osteosynthesis with IM nail: lateral decubitus without fracture table].
    Acta Ortop Mex 2016 Nov-Dec;30(6):279-283
    Hospital Ángeles Pedregal, Periférico Sur Núm. 3707, Col. Héroes de Padierna, Del. Magdalena Contreras, CP 10700 Ciudad de México.
    Background: Hip fractures have increased in the last decades, mainly in elderly patients with osteoporosis. The incidence becomes in some countries up to 250 thousand new cases per year, generating millions for health systems costs, so it should be considered a public health problem. They are treated in supine position, with a fracture table, through a lateral approach. Read More

    Marked variability observed in inpatient management of bronchiolitis in three Finnish hospitals.
    Acta Paediatr 2017 Sep 16;106(9):1512-1518. Epub 2017 Jun 16.
    Department of Paediatrics and Adolescent Medicine, Turku University Hospital, Turku, Finland.
    Aim: Infants hospitalised for bronchiolitis undergo examinations and treatments not supported by current research evidence and we investigated practice variations with regard to Finnish children under the age of two.

    Methods: This prospective, multicentre cohort study was conducted in paediatric units in three university hospitals in Finland from 2008 to 2010. Hospital medical records were reviewed to collect data on clinical course, testing and treatment. Read More

    [Trichomycosis (trichobacteriosis) capitis in an infant: Microbiological, dermoscopic and ultrastructural features].
    Rev Chil Pediatr 2017 Apr;88(2):258-262
    Servicio de Dermatología, Hospital Infantil de México Dr. Federico Gómez, Ciudad de México, México.
    Trichomycosis is a superficial infection caused by Corynebacterium flavescens, which regularly affects axillary, and to a a lesser extent, pubic, scrotal and intergluteal, and exceptionally, head hairs or trichomycosis capitis (TC). This condition is characterised by the formation of bacterial nodules. Clinically, it can be confused with white piedra or pediculosis. Read More

    Serum LL-37 Levels Associated With Severity of Bronchiolitis and Viral Etiology.
    Clin Infect Dis 2017 Sep;65(6):967-975
    Department of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston.
    Background: LL-37 is a host defense peptide with antimicrobial and immunomodulatory properties. We examined the relation of serum LL-37 levels to the severity of bronchiolitis and viral etiology.

    Methods: We performed a 17-center prospective cohort study in infants hospitalized with bronchiolitis over 3 winters (2011-2014). Read More

    High prevalence of cardiovascular risk factors in Peruvian adolescents living in a peri-urban shantytown: a cross-sectional study.
    J Health Popul Nutr 2017 May 22;36(1):19. Epub 2017 May 22.
    Departments of Neurology, Global Health and Medicine (Infectious Disease) of University of Washington, 325 Ninth Avenue, Seattle, WA, USA.
    Background: Adults of the peri-urban Peruvian shantytown of Lomas de Zapallal have a high prevalence of risk factors for developing cardiovascular disease (CVD)-likely due to behavioral choices established during childhood and adolescence. To guide the development of community-based risk reduction programs, we assessed the prevalence of risk factors for developing CVD among adolescents.

    Methods: We collected cross sectional data from adolescents of Peruvian peri-urban shantytown to evaluate four domains of CVD risk factors: (1) clinical (blood pressure, fasting blood glucose, and blood lipids), (2) anthropometric (height, weight, and waist circumference), (3) behavioral (physical activity, diet, and substance abuse), and (4) psychosocial (mental health and violence). Read More

    Characterizing the Cellular Immune Response to Parainfluenza Virus 3.
    J Infect Dis 2017 Jul;216(2):153-161
    Center for Cell and Gene Therapy, Baylor College of Medicine, Texas Children's Hospital, and Houston Methodist Hospital.
    Parainfluenza virus type 3 (PIV3) infections are a major cause of morbidity and mortality in immunocompromised individuals, with no approved therapies. Our group has demonstrated the safety and efficacy of adoptively transferred virus-specific T cells for the prevention and treatment of a broad range of viral infections including BK virus, cytomegalovirus, adenovirus, human herpesvirus 6, and Epstein-Barr virus. However, this approach is restricted to well-characterized viruses with known immunogenic/protective T-cell target antigens, precluding extension to PIV3. Read More

    Topical corticosteroid phobia in atopic dermatitis: International feasibility study of the TOPICOP score.
    Allergy 2017 Nov 22;72(11):1713-1719. Epub 2017 May 22.
    Department of Dermatology, Nantes University Hospital, Nantes, France.
    Background: Adherence to topical corticosteroids (TCS) is essential for the effective treatment of atopic dermatitis but can be limited by concerns about their use. This study examined the feasibility of applying the validated TOPICOP score for assessing TCS phobia across different countries.

    Methods: This was a prospective multicentre feasibility study conducted in 21 hospitals in 17 countries. Read More

    Differences between 2nd and 3rd generation seric parathormone determination methods on mortality in haemodialysis patients.
    Nefrologia 2017 Jul - Aug;37(4):389-396. Epub 2017 Apr 14.
    Servicio de Nefrología, Fundación Jiménez Díaz, Madrid, España; Instituto de Investigación Sanitaria, Fundación Jiménez Díaz (IIS-FJD), Madrid, España; Servicio de Nefrología, Fundación Jiménez Díaz, Universidad Autónoma de Madrid, Madrid, España. Electronic address:
    Parathormone plays a key role in controlling mineral metabolism. PTH is considered a uremic toxin causing cardiovascular damage and cardiovascular mortality in dialysis patients. There are two different assays to measure PTH called 2nd generation or intact PTH (iPTH) and 3rd generation or bioPTH (PTHbio). Read More

    Sequence variability of the respiratory syncytial virus (RSV) fusion gene among contemporary and historical genotypes of RSV/A and RSV/B.
    PLoS One 2017 17;12(4):e0175792. Epub 2017 Apr 17.
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, United States of America.
    Background: The fusion (F) protein of RSV is the major vaccine target. This protein undergoes a conformational change from pre-fusion to post-fusion. Both conformations share antigenic sites II and IV. Read More

    Immunogenicity and safety of a respiratory syncytial virus fusion protein (RSV F) nanoparticle vaccine in older adults.
    Immun Ageing 2017 12;14. Epub 2017 Apr 12.
    Novavax, Inc, 20 Firstfield Road, Gaithersburg, MD 20878 USA.
    Background: A preventative strategy for Respiratory Syncytial Virus (RSV) infection constitutes an under-recognized unmet medical need among older adults. Four formulations of a novel recombinant RSV F nanoparticle vaccine (60 or 90 μg RSV F protein, with or without aluminum phosphate adjuvant) administered concurrently with a licensed inactivated trivalent influenza vaccine (TIV) in older adult subjects were evaluated for safety and immunogenicity in this randomized, observer-blinded study.

    Results: A total of 220 healthy males and females ≥ 60 years of age, without symptomatic cardiopulmonary disease, were vaccinated concurrently with TIV and RSV F vaccine or placebo. Read More

    Clinical Profiles of Respiratory Syncytial Virus Subtypes A AND B Among Children Hospitalized with Bronchiolitis.
    Pediatr Infect Dis J 2017 Aug;36(8):808-810
    From the *Department of Pediatric Infectious Diseases, Arnold Palmer Hospital for Children, Orlando, Florida; †Department of Medicine, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts; ‡Departments of Molecular Virology and Microbiology and Pediatrics, Baylor College of Medicine, Houston, Texas; and §Department of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
    In this analysis of a prospective, multicenter study of children hospitalized with bronchiolitis, 925 had respiratory syncytial virus (RSV)-A and 649 had RSV-B. Overall, bronchiolitis severity did not differ by RSV subtype. However, among children with RSV-only bronchiolitis, those children with RSV-A had higher risk of intensive care treatment (odds ratio, 1. Read More

    A decrease in intact parathyroid hormone (iPTH) levels is associated with higher mortality in prevalent hemodialysis patients.
    PLoS One 2017 24;12(3):e0173831. Epub 2017 Mar 24.
    Servicio de Nefrología, Fundación Jiménez Díaz, Madrid, España.
    Background: The mortality of dialysis patients is 10- to 100-fold higher than in the general population. Baseline serum PTH levels, and more recently, changes in serum PTH levels (ΔPTH) over time, have been associated to mortality in dialysis patients.

    Methods: We explored the relationship between ΔPTH over 1 year with mortality over the next year in a prospective cohort of 115 prevalent hemodialysis patients from a single center that had median baseline iPTH levels within guideline recommendations. Read More

    Genomic Loads and Genotypes of Respiratory Syncytial Virus: Viral Factors during Lower Respiratory Tract Infection in Chilean Hospitalized Infants.
    Int J Mol Sci 2017 Mar 21;18(3). Epub 2017 Mar 21.
    Department of Pediatrics and Pediatric Surgery, Hospital Roberto del Río, Facultad de Medicina, Universidad de Chile, Profesor Zañartu 1085, Independencia, 8380418 Santiago, Chile.
    The clinical impact of viral factors (types and viral loads) during respiratory syncytial virus (RSV) infection is still controversial, especially regarding newly described genotypes. In this study, infants with RSV bronchiolitis were recruited to describe the association of these viral factors with severity of infection. RSV antigenic types, genotypes, and viral loads were determined from hospitalized patients at Hospital Roberto del Río, Santiago, Chile. Read More

    The Influence of Exercise on Cognitive Function in Older Hispanic/Latino Adults: Results From the "¡Caminemos!" Study.
    Gerontologist 2017 Nov;57(6):1072-1083
    Department of Medicine, David Geffen School of Medicine at UCLA and VA Greater Los Angeles Geriatric Research Education and Clinical Center, Los Angeles, California.
    Purpose Of The Study: We examined the prospective effect of an evidence-based exercise intervention (¡Caminemos!) on cognitive function among older Hispanic/Latino adults and the potential synergistic effects (if any) of an attribution-retraining intervention given to a random sample to counter negative ascriptions of the aging process.

    Design And Methods: We analyzed baseline and follow-up (1- and 2-year) data collected from Hispanics/Latinos ≥60 years (N = 571) who participated in ¡Caminemos! across 27 senior centers. All participants were randomly assigned to either (a) the treatment group-a 1-hr attribution-retraining session plus a 1-hr exercise class or (b) the control group-health education plus a 1-hr exercise class. Read More

    The relationship between nasopharyngeal CCL5 and microbiota on disease severity among infants with bronchiolitis.
    Allergy 2017 Nov 12;72(11):1796-1800. Epub 2017 Apr 12.
    Department of Emergency Medicine, Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA.
    Emerging evidence suggests that the airway microbiota plays an important role in viral bronchiolitis pathobiology. However, little is known about the combined role of airway microbiota and CCL5 in infants with bronchiolitis. In this multicenter prospective cohort study of 1005 infants (age <1 year) hospitalized for bronchiolitis during 2011-2014, we observed statistically significant interactions between nasopharyngeal airway CCL5 levels and microbiota profiles with regard to the risk of both intensive care use (P=. Read More

    The interdependencies of viral load, the innate immune response, and clinical outcome in children presenting to the emergency department with respiratory syncytial virus-associated bronchiolitis.
    PLoS One 2017 7;12(3):e0172953. Epub 2017 Mar 7.
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, United States of America.
    Respiratory syncytial virus (RSV) causes significant infant morbidity and mortality. For decades severe RSV-induced disease was thought to result from an uncontrolled host response to viral replication, but recent work suggests that a strong innate immune response early in infection is protective. To shed light on host-virus interactions and the viral determinants of disease, copy numbers of five RSV genes (NS1, NS2, N, G, F) were measured by quantitative real-time polymerase chain reaction (qPCR) in nasal wash samples from children with RSV-associated bronchiolitis. Read More

    [Rapidly progressive dementia and parkinsonism associated to multiple dural arteriovenous fistulas].
    Rev Neurol 2017 Mar;64(5):214-218
    Hospital Jose Carrasco Arteaga, Azuay, Ecuador.
    Introduction: Rapidly progressive dementias are an infrequent group of diseases characterised by cognitive deterioration and other neurological disorders that develop over a period ranging from weeks to months. Their causation is varied and includes a large number of neurodegenerative, toxic, metabolic, autoimmune, infectious and vascular conditions.

    Case Report: We report the case of a 69-year-old male who was admitted to hospital due to a rapidly progressive dementia and parkinsonism caused by multiple dural arteriovenous fistulas, which were successfully treated by means of endovascular therapy. Read More

    Very high MHC Class IIB diversity without spatial differentiation in the mediterranean population of greater Flamingos.
    BMC Evol Biol 2017 Feb 20;17(1):56. Epub 2017 Feb 20.
    Université de Bourgogne, Equipe Ecologie Evolutive, UMR CNRS 6282 Biogéosciences, 6 bd. Gabriel, 21000, Dijon, France.
    Background: Selective pressure from pathogens is thought to shape the allelic diversity of major histocompatibility complex (MHC) genes in vertebrates. In particular, both local adaptation to pathogens and gene flow are thought to explain a large part of the intraspecific variation observed in MHC allelic diversity. To date, however, evidence that adaptation to locally prevalent pathogens maintains MHC variation is limited to species with limited dispersal and, hence, reduced gene flow. Read More

    The Usefulness of Bone Biomarkers for Monitoring Treatment Disease: A Comparative Study in Osteolytic and Osteosclerotic Bone Metastasis Models.
    Transl Oncol 2017 Apr 16;10(2):255-261. Epub 2017 Feb 16.
    Bioquímica Investigación, Instituto de Investigación Sanitaria Fundación Jiménez Díaz, Madrid, Spain. Electronic address:
    Background: The skeleton is the most common site of colonization by metastatic cancers. Zoledronic acid (ZA) has been shown to be effective for the treatment of bone metastases regardless of whether the bone lesions are osteolytic or osteoblastic. Biochemical markers of bone turnover may be useful tools to quantify the degree of bone remodeling in the presence of bone metastases. Read More

    New records of Ornithodoros puertoricensis Fox 1947 (Ixodida: Argasidae) parasitizing humans in rural and urban dwellings, Panama.
    Ticks Tick Borne Dis 2017 Jun 5;8(4):466-469. Epub 2017 Feb 5.
    Department of Pediatrics, National School of Tropical Medicine, Baylor College of Medicine, TX, USA; Department of Molecular Virology and Microbiology, Baylor College of Medicine, TX, USA.
    The presence of ticks inside human constructions was evaluated in two localities from Colon province (Charco La Piedra and Espinar) and one from Panama province (Ancon, City of Panama). In two of houses, eight people from Charco La Piedra and one from Ancón reported "insect bites," which produced blisters for several weeks. The investigation resulted in the collection of argasid ticks, which were identified by morphology and sequencing the 16s ribosomal RNA gene, and later evaluated for the presence of relapsing fever Borrelia DNA. Read More

    Alchemy, Prophecy, and Politics in Eighteenth-Century Iberia: Anselmo Castelo Branco's Critique of Benito Feijoo.
    Ambix 2016 Nov 30;63(4):304-325. Epub 2017 Jan 30.
    a Independent scholar , Haarlem , The Netherlands.
    The Benedictine monk Benito Jerónimo Feijoo (1676-1764) is now considered one of the major figures of the Spanish and Iberian Enlightenment. However his work, both in Spain and in Portugal, was far from being universally acclaimed. His critical approach to the subject of alchemy in his essay "Piedra Filosofal," published in the third volume of his magisterial Teatro Crítico Universal (1726-1739), sparked an unexpected response from the Portuguese alchemist Anselmo Castelo Branco, who sought to refute Feijoo's claims in his own work, the Ennoea. Read More

    Validity of a PCR assay in CSF for the diagnosis of neurocysticercosis.
    Neurol Neuroimmunol Neuroinflamm 2017 Mar 16;4(2):e324. Epub 2017 Jan 16.
    Facultad de Ciencias Médicas (A. Carpio, A. Campoverde, L.G., L.M.P.), Universidad de Cuenca, Ecuador; GH Sergievsky Center (A. Carpio), College of Physicians and Surgeons, Columbia University; Department of Epidemiology and Biostatistics (M.L.R.), CUNY Graduate School of Public Health and Health Policy, City University of New York, NY; Hospital del Instituto Ecuatoriano de Seguridad Social (L.M.P., N.L.), José Carrasco Arteaga; Hospital Vicente Corral Moscoso (M.P., J.A.), Ministerio de Salud Pública; Hospital Santa Inés (S.L.); Clínica Santa Ana (L.C.V.); and Hospital Universitario del Río (A.M.T., P.P.-T.), Cuenca, Ecuador.
    Objective: To prospectively evaluate the validity of a PCR assay in CSF for the diagnosis of neurocysticercosis (NC).

    Methods: We conducted a multicenter, prospective case-control study, recruiting participants from 5 hospitals in Cuenca, Ecuador, from January 2015 to February 2016. Cases fulfilled validated diagnostic criteria for NC. Read More

    Nasal Airway Microbiota Profile and Severe Bronchiolitis in Infants: A Case-control Study.
    Pediatr Infect Dis J 2017 Nov;36(11):1044-1051
    From the *Department of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts; †Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia; ‡Department of Medicine, Boston Children's Hospital, Boston, Massachusetts; §Alkek Center for Metagenomics and Microbiome Research, Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas; ¶Department of Molecular Virology and Microbiology, and Pediatrics, Baylor College of Medicine, Houston, Texas; ‖Department of Pediatrics, University of Louisville, Louisville, Kentucky; and **Alfred I. duPont Hospital for Children, Wilmington, Delaware.
    Background: Little is known about the relationship of airway microbiota with bronchiolitis in infants. We aimed to identify nasal airway microbiota profiles and to determine their association with the likelihood of bronchiolitis in infants.

    Methods: A case-control study was conducted. Read More

    A live RSV vaccine with engineered thermostability is immunogenic in cotton rats despite high attenuation.
    Nat Commun 2016 Dec 21;7:13916. Epub 2016 Dec 21.
    Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia 30322, USA.
    Respiratory syncytial virus (RSV) is a leading cause of infant hospitalization and there remains no pediatric vaccine. RSV live-attenuated vaccines (LAVs) have a history of safe testing in infants; however, achieving an effective balance of attenuation and immunogenicity has proven challenging. Here we seek to engineer an RSV LAV with enhanced immunogenicity. Read More


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