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    Differences between 2nd and 3rd generation seric parathormone determination methods on mortality in haemodialysis patients.
    Nefrologia 2017 Apr 14. Epub 2017 Apr 14.
    Servicio de Nefrología, Fundación Jiménez Díaz, Madrid, España; Instituto de Investigación Sanitaria, Fundación Jiménez Díaz (IIS-FJD), Madrid, España; Servicio de Nefrología, Fundación Jiménez Díaz, Universidad Autónoma de Madrid, Madrid, España. Electronic address:
    Parathormone plays a key role in controlling mineral metabolism. PTH is considered a uremic toxin causing cardiovascular damage and cardiovascular mortality in dialysis patients. There are two different assays to measure PTH called 2nd generation or intact PTH (iPTH) and 3rd generation or bioPTH (PTHbio). Read More

    Sequence variability of the respiratory syncytial virus (RSV) fusion gene among contemporary and historical genotypes of RSV/A and RSV/B.
    PLoS One 2017 17;12(4):e0175792. Epub 2017 Apr 17.
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, United States of America.
    Background: The fusion (F) protein of RSV is the major vaccine target. This protein undergoes a conformational change from pre-fusion to post-fusion. Both conformations share antigenic sites II and IV. Read More

    Immunogenicity and safety of a respiratory syncytial virus fusion protein (RSV F) nanoparticle vaccine in older adults.
    Immun Ageing 2017 12;14. Epub 2017 Apr 12.
    Novavax, Inc, 20 Firstfield Road, Gaithersburg, MD 20878 USA.
    Background: A preventative strategy for Respiratory Syncytial Virus (RSV) infection constitutes an under-recognized unmet medical need among older adults. Four formulations of a novel recombinant RSV F nanoparticle vaccine (60 or 90 μg RSV F protein, with or without aluminum phosphate adjuvant) administered concurrently with a licensed inactivated trivalent influenza vaccine (TIV) in older adult subjects were evaluated for safety and immunogenicity in this randomized, observer-blinded study.

    Results: A total of 220 healthy males and females ≥ 60 years of age, without symptomatic cardiopulmonary disease, were vaccinated concurrently with TIV and RSV F vaccine or placebo. Read More

    Clinical Profiles of Respiratory Syncytial Virus Subtypes A and B among Children Hospitalized with Bronchiolitis.
    Pediatr Infect Dis J 2017 Apr 5. Epub 2017 Apr 5.
    From the Department of Pediatric Infectious Diseases, Arnold Palmer Hospital for Children, Orlando, FL (FRL); Department of Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA (JMM); Departments of Molecular Virology and Microbiology, and Pediatrics, Baylor College of Medicine, Houston, TX (PAP); and Department of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA (KH, AFS, JAE, CAC).
    In this analysis of a prospective, multicenter study of children hospitalized with bronchiolitis, 925 had RSV-A and 649 had RSV-B. Overall, bronchiolitis severity did not differ by RSV subtype. However, among children with RSV-only bronchiolitis, those children with RSV-A had higher risk of intensive care treatment (OR, 1. Read More

    A decrease in intact parathyroid hormone (iPTH) levels is associated with higher mortality in prevalent hemodialysis patients.
    PLoS One 2017 24;12(3):e0173831. Epub 2017 Mar 24.
    Servicio de Nefrología, Fundación Jiménez Díaz, Madrid, España.
    Background: The mortality of dialysis patients is 10- to 100-fold higher than in the general population. Baseline serum PTH levels, and more recently, changes in serum PTH levels (ΔPTH) over time, have been associated to mortality in dialysis patients.

    Methods: We explored the relationship between ΔPTH over 1 year with mortality over the next year in a prospective cohort of 115 prevalent hemodialysis patients from a single center that had median baseline iPTH levels within guideline recommendations. Read More

    Genomic Loads and Genotypes of Respiratory Syncytial Virus: Viral Factors during Lower Respiratory Tract Infection in Chilean Hospitalized Infants.
    Int J Mol Sci 2017 Mar 21;18(3). Epub 2017 Mar 21.
    Department of Pediatrics and Pediatric Surgery, Hospital Roberto del Río, Facultad de Medicina, Universidad de Chile, Profesor Zañartu 1085, Independencia, 8380418 Santiago, Chile.
    The clinical impact of viral factors (types and viral loads) during respiratory syncytial virus (RSV) infection is still controversial, especially regarding newly described genotypes. In this study, infants with RSV bronchiolitis were recruited to describe the association of these viral factors with severity of infection. RSV antigenic types, genotypes, and viral loads were determined from hospitalized patients at Hospital Roberto del Río, Santiago, Chile. Read More

    The Influence of Exercise on Cognitive Function in Older Hispanic/Latino Adults: Results From the "¡Caminemos!" Study.
    Gerontologist 2017 Mar 15. Epub 2017 Mar 15.
    Department of Medicine, David Geffen School of Medicine at UCLA and VA Greater Los Angeles Geriatric Research Education and Clinical Center, Los Angeles, California.
    Purpose Of The Study: We examined the prospective effect of an evidence-based exercise intervention (¡Caminemos!) on cognitive function among older Hispanic/Latino adults and the potential synergistic effects (if any) of an attribution-retraining intervention given to a random sample to counter negative ascriptions of the aging process.

    Design And Methods: We analyzed baseline and follow-up (1- and 2-year) data collected from Hispanics/Latinos ≥60 years (N = 571) who participated in ¡Caminemos! across 27 senior centers. All participants were randomly assigned to either (a) the treatment group-a 1-hr attribution-retraining session plus a 1-hr exercise class or (b) the control group-health education plus a 1-hr exercise class. Read More

    The relationship between nasopharyngeal CCL5 and microbiota on disease severity among infants with bronchiolitis.
    Allergy 2017 Mar 17. Epub 2017 Mar 17.
    Department of Emergency Medicine, Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA.
    Emerging evidence suggests that the airway microbiota plays an important role in viral bronchiolitis pathobiology. However, little is known about the combined role of airway microbiota and CCL5 in infants with bronchiolitis. In this multicenter prospective cohort study of 1005 infants (age <1 year) hospitalized for bronchiolitis during 2011-2014, we observed statistically significant interactions between nasopharyngeal airway CCL5 levels and microbiota profiles with regard to the risk of both intensive care use (Pinteraction =. Read More

    The interdependencies of viral load, the innate immune response, and clinical outcome in children presenting to the emergency department with respiratory syncytial virus-associated bronchiolitis.
    PLoS One 2017 7;12(3):e0172953. Epub 2017 Mar 7.
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, United States of America.
    Respiratory syncytial virus (RSV) causes significant infant morbidity and mortality. For decades severe RSV-induced disease was thought to result from an uncontrolled host response to viral replication, but recent work suggests that a strong innate immune response early in infection is protective. To shed light on host-virus interactions and the viral determinants of disease, copy numbers of five RSV genes (NS1, NS2, N, G, F) were measured by quantitative real-time polymerase chain reaction (qPCR) in nasal wash samples from children with RSV-associated bronchiolitis. Read More

    [Rapidly progressive dementia and parkinsonism associated to multiple dural arteriovenous fistulas].
    Rev Neurol 2017 Mar;64(5):214-218
    Hospital Jose Carrasco Arteaga, Azuay, Ecuador.
    Introduction: Rapidly progressive dementias are an infrequent group of diseases characterised by cognitive deterioration and other neurological disorders that develop over a period ranging from weeks to months. Their causation is varied and includes a large number of neurodegenerative, toxic, metabolic, autoimmune, infectious and vascular conditions.

    Case Report: We report the case of a 69-year-old male who was admitted to hospital due to a rapidly progressive dementia and parkinsonism caused by multiple dural arteriovenous fistulas, which were successfully treated by means of endovascular therapy. Read More

    Very high MHC Class IIB diversity without spatial differentiation in the mediterranean population of greater Flamingos.
    BMC Evol Biol 2017 Feb 20;17(1):56. Epub 2017 Feb 20.
    Université de Bourgogne, Equipe Ecologie Evolutive, UMR CNRS 6282 Biogéosciences, 6 bd. Gabriel, 21000, Dijon, France.
    Background: Selective pressure from pathogens is thought to shape the allelic diversity of major histocompatibility complex (MHC) genes in vertebrates. In particular, both local adaptation to pathogens and gene flow are thought to explain a large part of the intraspecific variation observed in MHC allelic diversity. To date, however, evidence that adaptation to locally prevalent pathogens maintains MHC variation is limited to species with limited dispersal and, hence, reduced gene flow. Read More

    The Usefulness of Bone Biomarkers for Monitoring Treatment Disease: A Comparative Study in Osteolytic and Osteosclerotic Bone Metastasis Models.
    Transl Oncol 2017 Apr 16;10(2):255-261. Epub 2017 Feb 16.
    Bioquímica Investigación, Instituto de Investigación Sanitaria Fundación Jiménez Díaz, Madrid, Spain. Electronic address:
    Background: The skeleton is the most common site of colonization by metastatic cancers. Zoledronic acid (ZA) has been shown to be effective for the treatment of bone metastases regardless of whether the bone lesions are osteolytic or osteoblastic. Biochemical markers of bone turnover may be useful tools to quantify the degree of bone remodeling in the presence of bone metastases. Read More

    New records of Ornithodoros puertoricensis Fox 1947 (Ixodida: Argasidae) parasitizing humans in rural and urban dwellings, Panama.
    Ticks Tick Borne Dis 2017 Feb 5. Epub 2017 Feb 5.
    Department of Pediatrics, National School of Tropical Medicine, Baylor College of Medicine, TX, USA; Department of Molecular Virology and Microbiology, Baylor College of Medicine, TX, USA.
    The presence of ticks inside human constructions was evaluated in two localities from Colon province (Charco La Piedra and Espinar) and one from Panama province (Ancon, City of Panama). In two of houses, eight people from Charco La Piedra and one from Ancón reported "insect bites," which produced blisters for several weeks. The investigation resulted in the collection of argasid ticks, which were identified by morphology and sequencing the 16s ribosomal RNA gene, and later evaluated for the presence of relapsing fever Borrelia DNA. Read More

    Alchemy, Prophecy, and Politics in Eighteenth-Century Iberia: Anselmo Castelo Branco's Critique of Benito Feijoo.
    Ambix 2016 Nov 30;63(4):304-325. Epub 2017 Jan 30.
    a Independent scholar , Haarlem , The Netherlands.
    The Benedictine monk Benito Jerónimo Feijoo (1676-1764) is now considered one of the major figures of the Spanish and Iberian Enlightenment. However his work, both in Spain and in Portugal, was far from being universally acclaimed. His critical approach to the subject of alchemy in his essay "Piedra Filosofal," published in the third volume of his magisterial Teatro Crítico Universal (1726-1739), sparked an unexpected response from the Portuguese alchemist Anselmo Castelo Branco, who sought to refute Feijoo's claims in his own work, the Ennoea. Read More

    Validity of a PCR assay in CSF for the diagnosis of neurocysticercosis.
    Neurol Neuroimmunol Neuroinflamm 2017 Mar 16;4(2):e324. Epub 2017 Jan 16.
    Facultad de Ciencias Médicas (A. Carpio, A. Campoverde, L.G., L.M.P.), Universidad de Cuenca, Ecuador; GH Sergievsky Center (A. Carpio), College of Physicians and Surgeons, Columbia University; Department of Epidemiology and Biostatistics (M.L.R.), CUNY Graduate School of Public Health and Health Policy, City University of New York, NY; Hospital del Instituto Ecuatoriano de Seguridad Social (L.M.P., N.L.), José Carrasco Arteaga; Hospital Vicente Corral Moscoso (M.P., J.A.), Ministerio de Salud Pública; Hospital Santa Inés (S.L.); Clínica Santa Ana (L.C.V.); and Hospital Universitario del Río (A.M.T., P.P.-T.), Cuenca, Ecuador.
    Objective: To prospectively evaluate the validity of a PCR assay in CSF for the diagnosis of neurocysticercosis (NC).

    Methods: We conducted a multicenter, prospective case-control study, recruiting participants from 5 hospitals in Cuenca, Ecuador, from January 2015 to February 2016. Cases fulfilled validated diagnostic criteria for NC. Read More

    Nasal Airway Microbiota Profile and Severe Bronchiolitis in Infants: A Case-Control Study.
    Pediatr Infect Dis J 2016 Dec 21. Epub 2016 Dec 21.
    1Department of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA; 2Department of Pediatrics, Emory University School of Medicine, Atlanta, GA; 3Department of Medicine, Boston Children's Hospital, Boston, MA; 4Alkek Center for Metagenomics and Microbiome Research, Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX; 5Department of Molecular Virology and Microbiology, and Pediatrics, Baylor College of Medicine, Houston, TX; 6Department of Pediatrics, University of Louisville, Louisville, KY; and 7Alfred I. duPont Hospital for Children, Wilmington, DE.
    Background: Little is known about the relationship of airway microbiota with bronchiolitis in infants. We aimed to identify nasal airway microbiota profiles and to determine their association with the likelihood of bronchiolitis in infants.

    Methods: A case-control study. Read More

    A live RSV vaccine with engineered thermostability is immunogenic in cotton rats despite high attenuation.
    Nat Commun 2016 Dec 21;7:13916. Epub 2016 Dec 21.
    Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia 30322, USA.
    Respiratory syncytial virus (RSV) is a leading cause of infant hospitalization and there remains no pediatric vaccine. RSV live-attenuated vaccines (LAVs) have a history of safe testing in infants; however, achieving an effective balance of attenuation and immunogenicity has proven challenging. Here we seek to engineer an RSV LAV with enhanced immunogenicity. Read More

    Serum cathelicidin, nasopharyngeal microbiota, and disease severity among infants hospitalized with bronchiolitis.
    J Allergy Clin Immunol 2017 Apr 12;139(4):1383-1386.e6. Epub 2016 Nov 12.
    Department of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Mass.

    Latino immigrants, depressive symptoms, and cognitive behavioral therapy: A systematic review.
    J Affect Disord 2017 Jan 24;208:567-576. Epub 2016 Oct 24.
    School of Social Work, University of Illinois at Urbana-Champaign, USA.
    Background: In order to address the needs of the growing Latino immigrant population, this study aimed to systematically review peer-reviewed articles of intervention studies that used cognitive behavioral therapy to treat depressive symptoms among Latino immigrants in the U.S.

    Methods: We searched PsycINFO, PubMed, and Medline databases from January 1995 through July 2016 as part of a registered review protocol (PROSPERO) following PRISMA guidelines. Read More

    GDP-to-GTP exchange on the microtubule end can contribute to the frequency of catastrophe.
    Mol Biol Cell 2016 Nov 4;27(22):3515-3525. Epub 2016 May 4.
    Departments of Biophysics and Biochemistry, UT Southwestern Medical Center, Dallas, TX 75390
    Microtubules are dynamic polymers of αβ-tubulin that have essential roles in chromosome segregation and organization of the cytoplasm. Catastrophe-the switch from growing to shrinking-occurs when a microtubule loses its stabilizing GTP cap. Recent evidence indicates that the nucleotide on the microtubule end controls how tightly an incoming subunit will be bound (trans-acting GTP), but most current models do not incorporate this information. Read More

    Association of nasopharyngeal microbiota profiles with bronchiolitis severity in infants hospitalised for bronchiolitis.
    Eur Respir J 2016 Nov 6;48(5):1329-1339. Epub 2016 Oct 6.
    Dept of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
    Little is known about the relationship between the specific airway microbiota composition and severity of bronchiolitis. We aimed to identify nasopharyngeal microbiota profiles and link these profiles to acute severity in infants hospitalised for bronchiolitis.We conducted a multicentre prospective cohort study of 1005 infants (age <1 year) hospitalised for bronchiolitis over three winters, 2011-2014. Read More

    Hydrochemical and isotopes studies in a hypersaline wetland to define the hydrogeological conceptual model: Fuente de Piedra Lake (Malaga, Spain).
    Sci Total Environ 2017 Jan 25;576:335-346. Epub 2016 Oct 25.
    ETSI de Minas de Madrid, Universidad Politécnica de Madrid, C/Ríos Rosas, 21, 28003 Madrid, Spain. Electronic address:
    The Fuente de Piedra lake is a hypersaline wetland of great extension (13.5km(2)) and rich in aquatic birds and other species. It became therefore the third Spanish wetland to be included in the Ramsar convention and has been a "nature reserve" since 1984. Read More

    2014-2015 Influenza Vaccine Effectiveness in the United States by Vaccine Type.
    Clin Infect Dis 2016 Dec 4;63(12):1564-1573. Epub 2016 Oct 4.
    Centers for Disease Control and Prevention, Atlanta, Georgia.
    Background:  Circulating A/H3N2 influenza viruses drifted significantly after strain selection for the 2014-2015 vaccines. Also in 2014-2015, the Advisory Committee on Immunization Practices recommended preferential use of live attenuated influenza vaccine (LAIV) over inactivated influenza vaccine (IIV) among children aged 2-8 years.

    Methods:  Vaccine effectiveness (VE) across age groups and vaccine types was examined among outpatients with acute respiratory illness at 5 US sites using a test-negative design, that compared the odds of vaccination among reverse transcription polymerase chain reaction-confirmed influenza positives and negatives. Read More

    Anti-inflammatory effect of prophylactic macrolides on children with chronic lung disease: a protocol for a double-blinded randomised controlled trial.
    BMJ Open 2016 Sep 16;6(9):e012060. Epub 2016 Sep 16.
    Department of Pediatrics, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, Texas, USA.
    Introduction: Recent studies suggest that the high mortality rate of respiratory viral infections is a result of an overactive neutrophilic inflammatory response. Macrolides have anti-inflammatory properties, including the ability to downregulate the inflammatory cascade, attenuate excessive cytokine production in viral infections, and may reduce virus-related exacerbations. In this study, we will test the hypothesis that prophylactic macrolides will reduce the severity of respiratory viral illness in children with chronic lung disease by preventing the full activation of the inflammatory cascade. Read More

    Metabolic Features of Alcoholic Liver Disease.
    Rev Recent Clin Trials 2016 ;11(3):220-6
    Liver Research Unit, Medica Sur Clinic & Foundation, Puente de Piedra 150, Col. Toriello Guerra, ZP 14050, Mexico City, Mexico.
    Background: Alcoholic Liver Disease (ALD) can be defined as the hepatic manifestations caused by excessive alcohol intake. ALD comprises a spectrum from simple steatosis to cirrhosis.

    Objective: To review diverse clinical and metabolic characteristics and their impact in ALD. Read More

    An Unusual Case of White Piedra Due to Trichosporon inkin Mimicking Trichobacteriosis.
    Mycopathologia 2016 Dec 10;181(11-12):909-914. Epub 2016 Aug 10.
    Department of Dermatovenereology, West China Hospital, Sichuan University, Yuping Ran. No. 37, Guo Xue Xiang, Wuhou District, Chengdu, 610041, Sichuan Province, China.
    White piedra is a superficial mycosis characterized by soft, white-to-tan, irregular nodules attached to the hair shafts. A 36-year-old man presented with small lumps in his pubic hair, without any other symptoms. The clinical features were suggestive of trichobacteriosis. Read More

    Role of bioactive fatty acids in nonalcoholic fatty liver disease.
    Nutr J 2016 Aug 2;15(1):72. Epub 2016 Aug 2.
    Translational Research Unit, Medica Sur Clinic & Foundation, Puente de Piedra 150 Toriello Guerra, Tlalpan, ZC 14050, Mexico City, Mexico.
    Nonalcoholic fatty liver disease (NAFLD) is characterized by fat deposition in hepatocytes, and a strong association with nutritional factors. Dietary fatty acids are classified according to their biochemical properties, which confer their bioactive roles. Monounsaturated fatty acids have a dual role in various human and murine models. Read More

    Respiratory Syncytial Virus (RSV): Neutralizing Antibody, a Correlate of Immune Protection.
    Methods Mol Biol 2016 ;1442:77-91
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, BCM MS280, One Baylor Plaza, Houston, TX, 77030, USA.
    Assays that measure RSV-specific neutralizing antibody activity are very useful for evaluating vaccine candidates, performing seroprevalence studies, and detecting infection. Neutralizing antibody activity is normally measured by a plaque reduction neutralization assay or by a microneutralization assay with or without complement. These assays measure the functional capacity of serum (or other fluids) to neutralize virus infectivity in cells as compared to ELISA assays that only measure the binding capacity against an antigen. Read More

    The Fecal Microbiota Profile and Bronchiolitis in Infants.
    Pediatrics 2016 Jul;138(1)
    Department of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts;
    Background: Little is known about the association of gut microbiota, a potentially modifiable factor, with bronchiolitis in infants. We aimed to determine the association of fecal microbiota with bronchiolitis in infants.

    Methods: We conducted a case-control study. Read More

    A clustering approach to identify severe bronchiolitis profiles in children.
    Thorax 2016 Aug 23;71(8):712-8. Epub 2016 Jun 23.
    Department of Emergency Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA Harvard Medical School, Boston, Massachusetts, USA.
    Objective: Although bronchiolitis is generally considered a single disease, recent studies suggest heterogeneity. We aimed to identify severe bronchiolitis profiles using a clustering approach.

    Methods: We analysed data from two prospective, multicentre cohorts of children younger than 2 years hospitalised with bronchiolitis, one in the USA (2007-2010 winter seasons, n=2207) and one in Finland (2008-2010 winter seasons, n=408). Read More

    A Recombinant Respiratory Syncytial Virus Vaccine Candidate Attenuated by a Low-Fusion F Protein Is Immunogenic and Protective against Challenge in Cotton Rats.
    J Virol 2016 Aug 27;90(16):7508-18. Epub 2016 Jul 27.
    Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA Children's Healthcare of Atlanta, Atlanta, Georgia, USA
    Unlabelled: Although respiratory syncytial virus (RSV) is the leading cause of lower respiratory tract infections in infants, a safe and effective vaccine is not yet available. Live-attenuated vaccines (LAVs) are the most advanced vaccine candidates in RSV-naive infants. However, designing an LAV with appropriate attenuation yet sufficient immunogenicity has proven challenging. Read More

    Standard finishing categories for high-throughput sequencing of viral genomes.
    Rev Sci Tech 2016 Apr;35(1):43-52
    Viral genome sequencing has become the cornerstone of almost all aspects of virology. In particular, high-throughput, next-generation viral genome sequencing has become an integral part of molecular epidemiological investigations into outbreaks of viral disease, such as the recent outbreaks of Middle Eastern respiratory syndrome, Ebola virus disease and Zika virus infection. Multiple institutes have acquired the expertise and necessary infrastructure to perform such investigations, as evidenced by the accumulation of thousands of novel viral sequences over progressively shorter time periods. Read More

    Trichosporon isolation from human ungueal infections: is there a pathogenic role?
    An Bras Dermatol 2016 Apr;91(2):173-9
    Universidade Federal Fluminense, Niterói, RJ, Brazil.
    Background: Although dermatophytes are considered the major cause of onychomycosis, many reports have incriminated non-dermatophyte moulds and yeasts in the disease's etiology. Successive Trichosporon isolation from onychomycosis has led to the genus being suspected as a nail primary pathogen.

    Objective: To determine the prevalence of Trichosporon isolation in onychomycosis patients who attended a mycology diagnostic service in Rio de Janeiro, Brazil, between January 2003 and December 2006. Read More

    Robust Cytokine and Chemokine Response in Nasopharyngeal Secretions: Association With Decreased Severity in Children With Physician Diagnosed Bronchiolitis.
    J Infect Dis 2016 Aug 18;214(4):649-55. Epub 2016 May 18.
    Department of Pediatric Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston.
    Background: Bronchiolitis causes substantial disease in young children. Previous findings had indicated that a robust innate immune response was not associated with a poor clinical outcome in bronchiolitis. This study tested the hypothesis that increased concentrations of cytokines and chemokines in nasal wash specimens were associated with decreased severity in bronchiolitis. Read More

    Enhanced Genetic Characterization of Influenza A(H3N2) Viruses and Vaccine Effectiveness by Genetic Group, 2014-2015.
    J Infect Dis 2016 Oct 6;214(7):1010-9. Epub 2016 May 6.
    Influenza Division, Centers for Disease Control and Prevention.
    Background: During the 2014-2015 US influenza season, expanded genetic characterization of circulating influenza A(H3N2) viruses was used to assess the impact of the genetic variability of influenza A(H3N2) viruses on influenza vaccine effectiveness (VE).

    Methods: A novel pyrosequencing assay was used to determine genetic group, based on hemagglutinin (HA) gene sequences, of influenza A(H3N2) viruses from patients enrolled at US Influenza Vaccine Effectiveness Network sites. VE was estimated using a test-negative design comparing vaccination among patients infected with influenza A(H3N2) viruses and uninfected patients. Read More

    [Minimal invasive anterolateral ankle stabilization with a modified Hemi-Castaing technique].
    Acta Ortop Mex 2015 Jul-Aug;29(4):212-7
    División de Ortopedia, Hospital General "Dr. Manuel Gea González", Av. Calzada de Tlalpan 4800, Tlalpan, Sección XVI, 14080 Ciudad de México, D.F.
    Background: The lesions to the lateral ligaments of the ankle are a common sports related injury. There are multiple surgical technics to address the problem all with a common goal: achieve a proper stability of the ankle. The improvements in the minimal invasive technics as well as those in the materials to fixate bone-tissue have also impacted the technics for lateral stabilization of the ankle. Read More

    Onycholysis and Chromonychia: A Case Caused by Trichosporon inkin.
    Skin Appendage Disord 2016 Feb 24;1(3):144-6. Epub 2015 Nov 24.
    Mycology Section, Department of Dermatology, 'Dr. Manuel Gea Gonzalez' General Hospital, Mexico City, Mexico.
    Yeasts cause only 5-10% of onychomycosis; the most common yeast is Candida albicans, and rarely Trichosporon spp. is found. Recently, it has become an important cause of fungemia with a high mortality rate in immunocompromised patients. Read More

    [Trichomycosis (trichobacteriosis) capitis in an infant. Microbiological, dermoscopic and ultrastructural features].
    Rev Chil Pediatr 2016 May 5. Epub 2016 May 5.
    Servicio de Dermatología, Hospital Infantil de México Dr. Federico Gómez, Ciudad de México, México.
    Introduction: Trichomycosis is a superficial infection caused by Corynebacterium flavescens, which regularly affects axillary, and to a a lesser extent, pubic, scrotal and intergluteal, and exceptionally, head hairs or trichomycosis capitis (TC). This condition is characterised by the formation of bacterial nodules. Clinically, it can be confused with white piedra or pediculosis. Read More

    Respiratory syncytial virus and rhinovirus severe bronchiolitis are associated with distinct nasopharyngeal microbiota.
    J Allergy Clin Immunol 2016 Jun 6;137(6):1909-1913.e4. Epub 2016 Apr 6.
    Department of Emergency Medicine, Massachusetts General Hospital, Boston, Mass; Division of Rheumatology, Allergy and Immunology, Department of Medicine, Massachusetts General Hospital, Boston, Mass.

    Metal(loid) Contamination in Seafood Products.
    Crit Rev Food Sci Nutr 2016 Apr 6. Epub 2016 Apr 6.
    a Instituto de Agroquímica y Tecnología de los Alimentos. Av. Agustín Escardino, 9 , 46980 Paterna, Valencia , Spain.
    Seafood products are important sources of proteins, polyunsaturated lipids and phospholipids, and also of numerous micronutrients (vitamins and minerals). However, they may also present chemical contaminants that can constitute a health risk and that must be considered when evaluating the risk/benefit associated with consumption of this group of foods. Toxic metals and metalloids in seafood, such as mercury (Hg), cadmium (Cd), arsenic (As) and lead (Pb), are subjected to legislative control in order to provide the consumer with safe seafood. Read More

    [The diagnosis artifice].
    Rev Med Inst Mex Seguro Soc 2016 Mar-Apr;54(2):140-1
    Secretario de Enseñanza Clínica e Internado Médico, Facultad de Medicina, Universidad Nacional Autónoma de México, Ciudad de México, México.
    The clinical diagnosis is considered the cornerstone in the decisions making process, since it has various functions, including the executive. However, the diagnosis is not only a goal by itself, but a mean to help patients. It is not enough to identify how the disease which ails the patient is called; the diagnosis must be individualized as much as possible in each case, for the mere mention of the diagnosis can mean a wide variety of problems. Read More

    Treatment for small cell lung cancer, where are we now?-a review.
    Transl Lung Cancer Res 2016 Feb;5(1):26-38
    1 Fundación Clínica, Médica Sur. Puente de piedra 150, Col Toriello Guerra, 14050 Mexico City, Mexico ; 2 Translational Research Laboratory, Catalan Institute of Oncology, Hospital Germans Trias i Pujol, Badalona, 08916 Barcelona, Spain ; 3 Dr Rosell Oncology Institute, Quirón Dexeus University Hospital, 08028 Barcelona, Spain.
    Small cell lung cancer (SCLC) represents between 13% and 15% of all diagnosed lung cancers worldwide. It is an aggressive neoplasia, with a 5-year mortality of 90% or more. It has historically been classified as limited disease (LD) and extensive disease (ED) in most study protocols. Read More

    Relevance of dosage in adherence to treatment with long-acting anticholinergics in patients with COPD.
    Int J Chron Obstruct Pulmon Dis 2016 10;11:289-93. Epub 2016 Feb 10.
    Department of Primary Care, Guadalajara Integrated Care Management, Guadalajara, Spain.
    Introduction: The aim of this study was to assess the degree of adherence for two standard regimens for administrating anticholinergic drugs (12 and 24 hours) in patients with chronic obstruction of the airflow and to establish whether the use of a once-daily dose improves the level of treatment adherence.

    Methods: We used long-acting anticholinergics (LAMAs) as a study variable, and included the entire health area of Castile-La Mancha, numbering 2,100,998 inhabitants, as the study population. We analyzed a total of 16,446 patients who had been prescribed a LAMA between January 1, 2013 and December 31, 2013. Read More

    Children Hospitalized with Rhinovirus Bronchiolitis Have Asthma-Like Characteristics.
    J Pediatr 2016 May 11;172:202-204.e1. Epub 2016 Feb 11.
    Department of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
    Children with bronchiolitis often are considered a homogeneous group. However, in a multicenter, prospective study of 2207 young children hospitalized for bronchiolitis, we found that children with respiratory syncytial virus detected differ from those with rhinovirus detected; the latter patients resemble older children with asthma, including more frequent treatment with corticosteroids. Read More

    Influenza Vaccine Effectiveness Against 2009 Pandemic Influenza A(H1N1) Virus Differed by Vaccine Type During 2013-2014 in the United States.
    J Infect Dis 2016 May 6;213(10):1546-56. Epub 2016 Jan 6.
    Centers for Disease Control and Prevention, Atlanta, Georgia.
    Background: The predominant strain during the 2013-2014 influenza season was 2009 pandemic influenza A(H1N1) virus (A[H1N1]pdm09). This vaccine-component has remained unchanged from 2009.

    Methods: The US Flu Vaccine Effectiveness Network enrolled subjects aged ≥6 months with medically attended acute respiratory illness (MAARI), including cough, with illness onset ≤7 days before enrollment. Read More

    GS-5806 Inhibits a Broad Range of Respiratory Syncytial Virus Clinical Isolates by Blocking the Virus-Cell Fusion Process.
    Antimicrob Agents Chemother 2015 Dec 14;60(3):1264-73. Epub 2015 Dec 14.
    Gilead Sciences, Foster City, California, USA.
    Respiratory syncytial virus (RSV) is a leading cause of lower respiratory tract infections in infants and young children. In addition, RSV causes significant morbidity and mortality in hospitalized elderly and immunocompromised patients. Currently, only palivizumab, a monoclonal antibody against the RSV fusion (F) protein, and inhaled ribavirin are approved for the prophylactic and therapeutic treatment of RSV, respectively. Read More

    Post-bronchiolitis Use of Asthma Medication: A Prospective 1-year Follow-up Study.
    Pediatr Infect Dis J 2016 Apr;35(4):363-8
    From the *Department of Pediatrics, Kuopio University Hospital, Kuopio, Finland; †Department of Pediatrics, Central Hospital of Central Finland, Jyväskylä, Finland; ‡Department of Pediatrics, Turku University Hospital, Turku, Finland; §Center for Child Health Research, Tampere University and University Hospital, Tampere, Finland; ¶Allergy Centre, Tampere University Hospital, Tampere, Finland; ‖Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; **Department of Molecular Virology and Microbiology and ††Department of Pediatrics, Baylor College of Medicine, Houston, Texas; and ‡‡Department of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
    Background: Our aim was to evaluate the association between viral findings during bronchiolitis and the use of asthma controller medication (primary outcome) and systemic corticosteroids (secondary outcome) during the first post-bronchiolitis year.

    Methods: We enrolled 408 children hospitalized for bronchiolitis at <24 months of age in a prospective, 3-center, 1-year follow-up study in Finland. Viruses were detected with polymerase chain reaction in nasopharyngeal aspirates. Read More

    Detection of respiratory syncytial virus and rhinovirus in healthy infants.
    BMC Res Notes 2015 Nov 25;8:718. Epub 2015 Nov 25.
    Department of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, 125 Nashua Street, Suite 920, Boston, MA, 02114, USA.
    Background: Despite the research importance of rhinovirus detection in asymptomatic healthy infants, the literature remains sparse.

    Objective: To investigate the prevalence of respiratory syncytial virus (RSV) and rhinovirus (and its species).

    Methods: We conducted a cross-sectional study of 110 healthy, non-hospitalized infants without acute illness at an academic medical center from November 2013 through May 2014. Read More

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