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Machine learning-based prediction of acute severity in infants hospitalized for bronchiolitis: a multicenter prospective study.

Sci Rep 2020 Jul 3;10(1):10979. Epub 2020 Jul 3.

Department of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, 125 Nashua Street, Suite 920, Boston, MA, 02114-1101, USA.

We aimed to develop machine learning models to accurately predict bronchiolitis severity, and to compare their predictive performance with a conventional scoring (reference) model. In a 17-center prospective study of infants (aged < 1 year) hospitalized for bronchiolitis, by using routinely-available pre-hospitalization data as predictors, we developed four machine learning models: Lasso regression, elastic net regression, random forest, and gradient boosted decision tree. We compared their predictive performance-e. Read More

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http://dx.doi.org/10.1038/s41598-020-67629-8DOI Listing

Detection of respiratory syncytial virus or rhinovirus weeks after hospitalization for bronchiolitis and the risk of recurrent wheezing.

J Infect Dis 2020 Jun 20. Epub 2020 Jun 20.

Department of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA.

Background: In severe bronchiolitis, it is unclear if delayed clearance or sequential infection of respiratory syncytial virus (RSV) or rhinovirus (RV) is associated with recurrent wheezing.

Methods: In a 17-center severe bronchiolitis cohort, we tested nasopharyngeal aspirates (NPA) upon hospitalization and parents collected nasal swabs ~3 weeks later (clearance swab) for respiratory viruses using PCR. The same RSV subtype or RV genotype in both the NPA and clearance swab defined delayed clearance (DC), while a new RSV subtype or RV genotype at clearance defined sequential infection (SI). Read More

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http://dx.doi.org/10.1093/infdis/jiaa348DOI Listing

Comorbidity burden in terms of disability in patients with osteoarthritis in Mexico. The IMPACTAR registry.

Reumatol Clin 2020 Jun 17. Epub 2020 Jun 17.

Instituto Nacional de Rehabilitación, Departamento de Reumatología, Calz México-Xochimilco 289, Arenal Tepepan, C.P. 14389 Mexico City, Mexico. Electronic address:

Objective: To determine the comorbidities associated with disability in patients with OA in Mexico (2013-2015).

Material And Methods: A cross-sectional, retrospective and multicentre IMPACTAR study (n=7703) in Mexican patients (2013-2015). Comorbidities associated with disability were identified in 4971 patients diagnosed with OA from the IMPACTAR registry (n=7073). Read More

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http://dx.doi.org/10.1016/j.reuma.2020.03.005DOI Listing

Respiratory Syncytial Virus-Associated Hospitalizations Among Young Children: 2015-2016.

Pediatrics 2020 Jul 16;146(1). Epub 2020 Jun 16.

Division of Viral Diseases and.

Background: Respiratory syncytial virus (RSV) is a major cause of hospitalized acute respiratory illness (ARI) among young children. With RSV vaccines and immunoprophylaxis agents in clinical development, we sought to update estimates of US pediatric RSV hospitalization burden.

Methods: Children <5 years old hospitalized for ARI were enrolled through active, prospective, population-based surveillance from November 1, 2015, to June 30, 2016, at 7 US pediatric hospital sites. Read More

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http://dx.doi.org/10.1542/peds.2019-3611DOI Listing

Vitamin D deficiency in Mexicans have a high prevalence: a cross-sectional analysis of the patients from the Centro Médico Nacional 20 de Noviembre.

Arch Osteoporos 2020 Jun 16;15(1):88. Epub 2020 Jun 16.

Translational Research Unit, Medica Sur Clinic & Foundation, Puente de Piedra 150, Toriello Guerra Tlalpan, C.P, 14050, Mexico City, Mexico.

Disorders of vitamin D concentration (deficiency or insufficiency) are a global health problem, which are associated with various chronic diseases. In Latin America, alterations in vitamin D prevalence are different from those shown in previous studies and may be due to differences in geographic location, skin color, and diet type.

Purpose: To know the prevalence of vitamin D insufficiency (21-29 ng/mL) and deficiency (< 20 ng/mL) in Mexican patients; although it is a risk factor for developing multiple complex diseases, its prevalence in the population is still unknown. Read More

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http://dx.doi.org/10.1007/s11657-020-00765-wDOI Listing

Non-alcoholic fatty liver disease and microRNAs expression, how it affects the development and progression of the disease.

Ann Hepatol 2020 Jun 6. Epub 2020 Jun 6.

Traslational Research Unit, Medica Sur Clinic & Foundation, Puente de Piedra 150, Toriello Guerra, Tlalpan, Z.C. 14050 Mexico City, Mexico. Electronic address:

The obesity pandemic that affects the global population generates one of the most unfavorable microenvironmental conditions in the hepatocyte, which triggers the metabolic hepatopathy known as non-alcoholic fatty liver; its annual rates increase in its prevalence and does not seem to improve in the future. The international consortia, LITMUS by the European Union and NIMBLE by the United States of America, have started a race for the development of hepatic steatosis and steatohepatitis reliable biomarkers to have an adequate diagnosis. MicroRNAs have been proposed as diagnostic and prognostic biomarkers involved in adaptation to changes in the liver microenvironment, which could improve clinical intervention strategies in patients with hepatic steatosis. Read More

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http://dx.doi.org/10.1016/j.aohep.2020.04.012DOI Listing
June 2020
2.193 Impact Factor

Severe Coronavirus Bronchiolitis in the Pre-COVID-19 Era.

Pediatrics 2020 Jun 10. Epub 2020 Jun 10.

Department of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1542/peds.2020-1267DOI Listing

Baloxavir Marboxil Single-dose Treatment in Influenza-infected Children: A Randomized, Double-blind, Active Controlled Phase 3 Safety and Efficacy Trial (miniSTONE-2).

Pediatr Infect Dis J 2020 Jun 5. Epub 2020 Jun 5.

Baylor College of Medicine, Houston, Texas.

Background: Baloxavir marboxil (baloxavir) is a novel, cap-dependent endonuclease inhibitor that has previously demonstrated efficacy in the treatment of influenza in adults and adolescents. We assessed the safety and efficacy of baloxavir in otherwise healthy children with acute influenza.

Methods: MiniSTONE-2 (Clinicaltrials. Read More

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http://dx.doi.org/10.1097/INF.0000000000002747DOI Listing

The Influence of Evidence-Based Exercise and Age Reattribution on Physical Function in Hispanic Older Adults: Results From the Randomized Controlled Trial.

J Appl Gerontol 2020 Jun 8:733464820927171. Epub 2020 Jun 8.

University of Illinois at Urbana-Champaign, USA.

Older Hispanics routinely exhibit unhealthy beliefs about "normal" aging trajectories, particularly related to exercise and physical function. We evaluated the prospective effects of age reattribution on physical function in older Hispanics. Participants ( = 565, ≥60 years) were randomly assigned into (a) treatment group-attribution-retraining, or (b) control group-health education. Read More

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http://dx.doi.org/10.1177/0733464820927171DOI Listing

Pelvic radiation therapy with volumetric modulated arc therapy and intensity-modulated radiotherapy after renal transplant: A report of 3 cases.

Rep Pract Oncol Radiother 2020 Jul-Aug;25(4):548-555. Epub 2020 Apr 28.

Radiotherapy and Medical Physics Department, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán. 15 Vasco de Quiroga, Belisario Domínguez, Sección XVI, Tlalpan, Mexico City, 14080, Mexico.

Aim: Describe characteristics and outcomes of three patients treated with pelvic radiation therapy after kidney transplant.

Background: The incidence of pelvic cancers in kidney transplant (KT) recipients is rising. Currently it is the leading cause of death. Read More

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http://dx.doi.org/10.1016/j.rpor.2020.04.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7256055PMC

Respiratory viruses are associated with serum metabolome among infants hospitalized for bronchiolitis: A multicenter study.

Pediatr Allergy Immunol 2020 May 27. Epub 2020 May 27.

Department of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

Background: Bronchiolitis is the leading cause of infant hospitalizations in the United States. Growing evidence supports the heterogeneity of bronchiolitis. However, little is known about the interrelationships between major respiratory viruses (and their species), host systemic metabolism, and disease pathobiology. Read More

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http://dx.doi.org/10.1111/pai.13296DOI Listing
May 2020
3.397 Impact Factor

Baloxavir Marboxil 2% Granules in Japanese Children With Influenza: An Open-label Phase 3 Study.

Pediatr Infect Dis J 2020 May 19. Epub 2020 May 19.

Project Management Department.

Background: A granule formulation of baloxavir marboxil, a selective inhibitor of influenza cap-dependent endonuclease, was newly developed for children with difficulty swallowing tablets.

Methods: A multicenter open-label study was conducted during the 2017-2018 influenza season to assess the safety, pharmacokinetics and clinical/virologic outcomes of single, oral, weight-based doses of baloxavir granules in Japanese children infected with influenza virus. The primary clinical endpoint was the time to illness alleviation of influenza. Read More

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http://dx.doi.org/10.1097/INF.0000000000002748DOI Listing

Effects of Virgin Olive Oil on Bone Health in Ovariectomized Rats.

Nutrients 2020 Apr 30;12(5). Epub 2020 Apr 30.

Biochemistry Research, Instituto de Investigación Sanitaria Fundación Jiménez Díaz, 28040 Madrid, Spain.

Osteoporosis is a pressing concern facing public health, thus making research into the effects of nutrients on bone health particularly important. Evidence from preclinical studies using animal models and a limited number of studies in human suggests that olive oil (OO) is a protective agent for bone. The aim of this work is to study the effects of virgin olive oil (VOO) consumption by ovariectomized rats on bone health. Read More

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http://dx.doi.org/10.3390/nu12051270DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7284979PMC

Synthesis and Sustainability Evaluation of a Lignocellulosic Multifeedstock Biorefinery Considering Technical Performance Indicators.

ACS Omega 2020 Apr 14;5(16):9259-9275. Epub 2020 Apr 14.

Process Design and Biomass Utilization Research Group (IDAB), Chemical Engineering Program, University of Cartagena, Campus Piedra de Bolívar, Street 30 #48-152, Cartagena 13000, Colombia.

Nowadays, green-chemistry principles offer an approach that fits to ensure chemical process sustainability by the use of low-cost renewable raw materials, waste prevention, inherent safer designs, among others. Based on this motivation, this study presents a novel methodology for sustainable process design that comprises the synthesis of a multifeedstock optimal biorefinery under simultaneous optimization of economic and environmental targets and further sustainability evaluation using the sustainability weighted return on investment metric (SWROIM). The first step of the proposed method is the formulation of an optimization model to generate the most suitable process alternatives. Read More

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http://dx.doi.org/10.1021/acsomega.0c00114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191568PMC

A Matter of Degrees: A Systematic Review of the Ergogenic Effect of Pre-Cooling in Highly Trained Athletes.

Int J Environ Res Public Health 2020 04 24;17(8). Epub 2020 Apr 24.

Department of Functional Biology, Universidad de Oviedo, 33006 Oviedo, Spain.

The current systematic review evaluated the effects of different pre-cooling techniques on sports performance in highly-trained athletes under high temperature conditions. PubMed/MEDLINE, EMBASE, Web of Science, CENTRAL, Scopus, and SPORTDiscus databases were searched from inception to December 2019. Studies performing pre-cooling interventions in non-acclimatized highly-trained athletes (>55 mL/kg/min of maximal oxygen consumption) under heat conditions (≥30 °C) were included. Read More

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http://dx.doi.org/10.3390/ijerph17082952DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7215649PMC

Antibody Response to the Furin Cleavable Twenty-Seven Amino Acid Peptide (p27) of the Fusion Protein in Respiratory Syncytial Virus (RSV) Infected Adult Hematopoietic Cell Transplant (HCT) Recipients.

Vaccines (Basel) 2020 Apr 21;8(2). Epub 2020 Apr 21.

Department of Molecular Virology & Microbiology, Baylor College of Medicine, Houston, TX 77030, USA.

Cleavage of the inactive precursor fusion protein (F0) of respiratory syncytial virus (RSV) at two furin-recognition sites is required for membrane fusion activity, and the cleavage releases the twenty-seven amino acid peptide (p27). However, a recent study shows that p27 was an immunodominant epitope in RSV infected children, indicating that p27 was recognized as an immunogen. In the present study, we investigated the immunogenicity of p27 in an immunocompromised population of adults by measuring serum and mucosal antibody responses to p27 in samples from adult hematopoietic cell transplant (HCT) recipients. Read More

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http://dx.doi.org/10.3390/vaccines8020192DOI Listing

Association of rhinovirus species with nasopharyngeal metabolome in bronchiolitis infants: A multicenter study.

Allergy 2020 Apr 18. Epub 2020 Apr 18.

Department of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1111/all.14326DOI Listing
April 2020
6.028 Impact Factor

Delirious mania as a frequent and recognizable neuropsychiatric syndrome in patients with anti-NMDAR encephalitis.

Gen Hosp Psychiatry 2020 May - Jun;64:50-55. Epub 2020 Mar 14.

Neuropsychiatry Unit, National Institute of Neurology and Neurosurgery of Mexico, Insurgentes Sur No. 3877 ZC, 14269 Mexico, Mexico; Neurology and Neurosurgery Center, Medica Sur Puente de Piedra 150, Toriello Guerra, Mexico, Mexico. Electronic address:

Background: Previous case reports showed that delirious mania could be one of the many neuropsychiatric presentations of Anti-N-methyl-d-aspartate receptor encephalitis (ANMDARE).

Objective: To evaluate the frequency of delirious mania and its associated factors in ANMDARE.

Method: A prospective study, including all patients with ANMDARE admitted to the National Institute of Neurology and Neurosurgery of Mexico, from January 2014 to April 2019. Read More

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http://dx.doi.org/10.1016/j.genhosppsych.2020.03.003DOI Listing

[Ferropenic anemia in premenopause].

Aten Primaria 2020 Mar 9. Epub 2020 Mar 9.

Departamento de Cirugía Ortopédica y Traumatología, Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz, Madrid, España. Electronic address:

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http://dx.doi.org/10.1016/j.aprim.2019.10.008DOI Listing

The Piedra Chamana fossil woods and leaves: a record of the vegetation and palaeoenvironment of the Neotropics during the late middle Eocene.

Ann Bot 2020 Jun;125(7):1077-1089

US National Park Service, Florissant Fossil Beds National Monument, Florissant, CO, USA.

Background And Aims: The Piedra Chamana fossil forest in northern Peru is an assemblage of angiosperm woods and leaves preserved in volcaniclastic rocks dated to 39 Mya (late Middle Eocene). We analysed the anatomical and morphological features of the fossils to reconstruct the palaeoenvironment during this time of global warmth, taking advantage of the co-occurrence of woods and leaves to compare different proxies and analytical approaches.

Methods: Wood characters analysed include vessel-related functional traits, traits linked to Baileyan trends, and quantitative features such as vessel diameter and density. Read More

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http://dx.doi.org/10.1093/aob/mcaa039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7262476PMC

Comparing Spirometric Reference Values From Childhood to Old Age Estimated by LMS and Linear Regression Models.

Arch Bronconeumol 2020 Feb 29. Epub 2020 Feb 29.

Department of Research in Smoking and COPD, National Institute of Respiratory Diseases "Ismael Cosío Villegas", Mexico City, Mexico. Electronic address:

Background: Proper reference values for lung function testing are essential for achieving adequate interpretations. The LMS procedure (lambda, mu, sigma) permits continuous analyses of entire populations avoiding gaps in the transition between childhood and adulthood. It also allows more precise calculations of average values, dispersion, and 5th percentiles, which are usually considered the lower limit of normality. Read More

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http://dx.doi.org/10.1016/j.arbres.2019.12.033DOI Listing
February 2020

Premature Infants with RSV: the Need for Both Maternal and Pediatric RSV Prevention Strategies.

J Infect Dis 2020 Feb 1. Epub 2020 Feb 1.

Departments of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas.

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http://dx.doi.org/10.1093/infdis/jiaa034DOI Listing
February 2020

The importance of image guided radiotherapy in small cell lung cancer: Case report and review of literature.

Rep Pract Oncol Radiother 2020 Jan-Feb;25(1):146-149. Epub 2019 Dec 20.

Instituto Nacional de Cancerologia (INCan), 22 San Fernando, Colonia Sección XVI, Mexico City, 14080.

Aim: Describe the anatomical changes and tumor displacement due to a rapid response of a patient's small cell lung cancer (SCLC) during definitive chemoradiotherapy (CRT).

Background: The treatment for SCLC is based on CRT. If interfractional changes during RT are incorrectly assessed they might compromise adequate coverage of the tumor or increase dose to organs at risk. Read More

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http://dx.doi.org/10.1016/j.rpor.2019.12.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6951087PMC
December 2019

Non-gradient and genotype-dependent patterns of RSV gene expression.

PLoS One 2020 10;15(1):e0227558. Epub 2020 Jan 10.

Department of Molecular Virology & Microbiology, Baylor College of Medicine, Houston, TX, United States of America.

Respiratory syncytial virus (RSV) is a nonsegmented negative-strand RNA virus (NSV) and a leading cause of severe lower respiratory tract illness in infants and the elderly. Transcription of the ten RSV genes proceeds sequentially from the 3' promoter and requires conserved gene start (GS) and gene end (GE) signals. Previous studies using the prototypical GA1 genotype Long and A2 strains have indicated a gradient of gene transcription extending across the genome, with the highest level of mRNA coming from the most promoter-proximal gene, the first nonstructural (NS1) gene, and mRNA levels from subsequent genes dropping until reaching a minimum at the most promoter-distal gene, the polymerase (L) gene. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0227558PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6953876PMC

Environmental and Safety Assessments of Industrial Production of Levulinic Acid via Acid-Catalyzed Dehydration.

ACS Omega 2019 Dec 20;4(27):22302-22312. Epub 2019 Dec 20.

Process Design and Biomass Utilization Research Group (IDAB), Chemical Engineering Program, University of Cartagena, Campus Piedra de Bolívar. Street 30 # 48-152, Cartagena 130000, Colombia.

These days, there is a need to develop novel and emerging processing pathways that permit production of value-added substances and fuels considering sustainability aspects. In this sense, levulinic acid (LA) is one of the most promising biorefinery products. This paper presents environmental and safety assessments of LA production via acid-catalyzed dehydration (ACD) of biomass. Read More

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http://dx.doi.org/10.1021/acsomega.9b02231DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6941184PMC
December 2019

Pre-Existing Comorbid Emotional Symptoms Moderate Short-Term Methylphenidate Adverse Effects in a Randomized Trial of Children with Attention-Deficit/Hyperactivity Disorder.

J Child Adolesc Psychopharmacol 2020 Apr 16;30(3):137-147. Epub 2019 Dec 16.

Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio.

We sought to ascertain whether baseline anxiety/depression and oppositional defiant disorder (ODD) symptoms impacted the experience of short-term methylphenidate (MPH) adverse effects (AEs) in 7- to 11-year-old children with attention-deficit/hyperactivity disorder (ADHD) ( = 171) undergoing a double-blind MPH crossover trial. The Vanderbilt ADHD Diagnostic Parent Rating Scale measured baseline child anxiety/depression and ODD symptomology. The parent-completed Pittsburgh Side Effect Rating Scale assessed the AEs of anxiety, sadness, and irritability at baseline, on placebo, and on three MPH dosages. Read More

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http://dx.doi.org/10.1089/cap.2019.0125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7153644PMC

Reversal of Resistance to the Larvicide Temephos in an Aedes aegypti (Diptera: Culicidae) Laboratory Strain From Cuba.

J Med Entomol 2020 May;57(3):801-806

Department of Vector Control, Center for Research, Diagnostic and Reference, Institute of Tropical Medicine Pedro Kourí, Havana, Cuba.

The objective of this investigation was to know whether the organophosphate temephos resistance developed in larvae from a laboratory strain of Aedes aegypti (Linnaeus, 1762) from Cuba could be reversed. The resistant laboratory strain of Ae. aegypti, named SAN-F6, was left without temephos selection pressure for 12 generations. Read More

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http://dx.doi.org/10.1093/jme/tjz206DOI Listing
May 2020
1.953 Impact Factor

Antigenic Fingerprinting of Respiratory Syncytial Virus (RSV)-A-Infected Hematopoietic Cell Transplant Recipients Reveals Importance of Mucosal Anti-RSV G Antibodies in Control of RSV Infection in Humans.

J Infect Dis 2020 Feb;221(4):636-646

Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA.

Background: Respiratory syncytial virus (RSV) infection causes significant morbidity in hematopoietic cell transplant (HCT) recipients. However, antibody responses that correlate with recovery from RSV disease are not fully understood.

Methods: In this study, antibody repertoire in paired serum and nasal wash samples from acutely RSV-A-infected HCT recipients who recovered early (<14 days of RSV shedding) were compared with late-recovered patients (≥14 days of shedding) using gene fragment phage display libraries and surface plasmon resonance. Read More

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http://dx.doi.org/10.1093/infdis/jiz608DOI Listing
February 2020

Increased Moraxella and Streptococcus species abundance after severe bronchiolitis is associated with recurrent wheezing.

J Allergy Clin Immunol 2020 Feb 15;145(2):518-527.e8. Epub 2019 Nov 15.

Department of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Mass.

Background: The role of the airway microbiome in the development of recurrent wheezing and asthma remains uncertain, particularly in the high-risk group of infants hospitalized for bronchiolitis.

Objective: We sought to examine the relation of the nasal microbiota at bronchiolitis-related hospitalization and 3 later points to the risk of recurrent wheezing by age 3 years.

Methods: In 17 US centers researchers collected clinical data and nasal swabs from infants hospitalized for bronchiolitis. Read More

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http://dx.doi.org/10.1016/j.jaci.2019.10.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7010548PMC
February 2020
11.476 Impact Factor

Interventions for pityriasis rosea.

Cochrane Database Syst Rev 2019 10 30;2019(10). Epub 2019 Oct 30.

The University of Nottingham, c/o Cochrane Skin Group, A103, King's Meadow Campus, Lenton Lane, Nottingham, UK, NG7 2NR.

Background: Pityriasis rosea is a scaly, itchy rash that mainly affects young adults and lasts for 2 to 12 weeks. The effects of many available treatments are uncertain. This is an update of a Cochrane Review first published in 2007. Read More

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http://dx.doi.org/10.1002/14651858.CD005068.pub3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6819167PMC
October 2019

Image Gallery: White piedra.

Br J Dermatol 2020 Mar 15;182(3):e86. Epub 2019 Oct 15.

Naval Hospital Guam, Agana Heights, Guam.

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http://dx.doi.org/10.1111/bjd.18532DOI Listing
March 2020
1 Read

Molecular Identification and Virulence Potential of the Genus Isolated from Wild Rainbow Trout () in Mexico.

J Food Prot 2019 Oct;82(10):1706-1713

Área Académica de Medicina Veterinaria y Zootecnia, Instituto de Ciencias Agropecuarias, Universidad Autónoma del Estado de Hidalgo, Tulancingo, Hidalgo 43600, México (ORCID: https://orcid.org/0000-0003-3466-8677 [V.V.-S.]).

The members of the genus are important foodborne pathogens, with a worldwide distribution. Wild rainbow trout, from the national protected area Santuario del Agua State Park, Corral de Piedra, were analyzed. Species of were isolated from the trout, and their pathogenic potential was analyzed based on different pathogenicity and virulence factors. Read More

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http://dx.doi.org/10.4315/0362-028X.JFP-18-545DOI Listing
October 2019
2 Reads

Rhinovirus Type in Severe Bronchiolitis and the Development of Asthma.

J Allergy Clin Immunol Pract 2020 Feb 11;8(2):588-595.e4. Epub 2019 Sep 11.

Department of Pediatrics and Adolescent Medicine, Turku University Hospital and University of Turku, Turku, Finland. Electronic address:

Background: Respiratory syncytial virus (RSV)- and rhinovirus (RV)-induced bronchiolitis are associated with an increased risk of asthma, but more detailed information is needed on virus types.

Objective: To study whether RSV or RV types are differentially associated with the future use of asthma control medication.

Methods: Over 2 consecutive winter seasons (2008-2010), we enrolled 408 children hospitalized for bronchiolitis at age less than 24 months into a prospective, 3-center, 4-year follow-up study in Finland. Read More

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http://dx.doi.org/10.1016/j.jaip.2019.08.043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7012669PMC
February 2020
5 Reads

Safety and Immunogenicity of a Respiratory Syncytial Virus Fusion (F) Protein Nanoparticle Vaccine in Healthy Third-Trimester Pregnant Women and Their Infants.

J Infect Dis 2019 10;220(11):1802-1815

Novavax, Inc., Gaithersburg, Maryland.

Background: Respiratory syncytial virus (RSV) is the leading cause of infant lower respiratory tract disease and hospitalization worldwide.

Methods: Safety and immunogenicity of RSV fusion (F) protein nanoparticle vaccine or placebo were evaluated in 50 healthy third-trimester pregnant women. Assessments included vaccine tolerability and safety in women and infants, and RSV-specific antibody measures in women before and after vaccination, at delivery and post partum. Read More

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http://dx.doi.org/10.1093/infdis/jiz390DOI Listing
October 2019
4 Reads

Acute Abdomen in Kawasaki Disease.

Indian J Pediatr 2019 12 7;86(12):1151-1152. Epub 2019 Aug 7.

Department of Clinical Immunology, Instituto Nacional de Pediatría, Insurgentes Cuicuilco, 04530, Mexico City, Mexico.

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http://dx.doi.org/10.1007/s12098-019-03048-6DOI Listing
December 2019
4 Reads

Understanding the association of polycystic ovary syndrome and non-alcoholic fatty liver disease.

J Steroid Biochem Mol Biol 2019 11 2;194:105445. Epub 2019 Aug 2.

Traslational Research Unit, Medica Sur Clinic & Foundation, Puente de Piedra 150, Toriello Guerra Tlalpan, Z.C. 14050, Mexico City, Mexico. Electronic address:

Polycystic ovary syndrome (PCOS) is the most common endocrine disorder among reproductive-age women. Patients with non-alcoholic fatty liver disease (NAFLD) often suffer from metabolic syndrome, atherosclerosis, ischemic heart disease, and extrahepatic tumors, conferring a lower survival than the general population; therefore it is crucial to study the association between NAFLD and PCOS since it remains poorly understood. Insulin resistance (IR) plays a central role in the pathogenesis of NAFLD and PCOS; also, hyperandrogenism enhances IR in these patients. Read More

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http://dx.doi.org/10.1016/j.jsbmb.2019.105445DOI Listing
November 2019
9 Reads
3.628 Impact Factor

A Case of Scalp White Piedra Caused by Trichosporon Ovoides.

Int J Trichology 2019 May-Jun;11(3):134-137

Department of Dermatology, Venereology and Leprosy, GMC, Kota, Rajasthan, India.

White piedra also known as trichomycosis nodularis or trichomycosis nodosa is a superficial fungal infection of the hair shaft caused by . We are reporting a case of white piedra in a female for the rarity of such occurrence. Read More

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http://dx.doi.org/10.4103/ijt.ijt_19_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6580808PMC
July 2019
4 Reads

Alkalinizing Agents: A Review of Prescription, Over-the-Counter, and Medical Food Supplements.

J Endourol 2020 Jan 25;34(1):1-6. Epub 2019 Sep 25.

Department of Urology, David Geffen School of Medicine at UCLA, Los Angeles.

Kidney stones affect 1 in every 11 people in the United States each year. There is a significant high recurrence rate without a stone prevention protocol. Alkali citrate is beneficial in decreasing stone recurrence, but because of the cost and gastrointestinal side effects there is a low adherence rate. Read More

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http://dx.doi.org/10.1089/end.2019.0292DOI Listing
January 2020
5 Reads

Respiratory Virus Epidemiology Among US Infants With Severe Bronchiolitis: Analysis of 2 Multicenter, Multiyear Cohort Studies.

Pediatr Infect Dis J 2019 08;38(8):e180-e183

From the Department of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.

In 2 multicenter cohort studies of 2912 infants hospitalized for bronchiolitis during 2007-2014, the 5 most common pathogens were RSV (76.5%), rhinovirus (23.8%), coronavirus (6. Read More

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http://dx.doi.org/10.1097/INF.0000000000002279DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6636850PMC
August 2019
9 Reads
2.723 Impact Factor

Efficacy and safety of nimotuzumab in addition to radiotherapy and temozolomide for cerebral glioblastoma: a phase II multicenter clinical trial.

J Cancer 2019 2;10(14):3214-3223. Epub 2019 Jun 2.

Department of Radiation Oncology, Sun Yat-sen University Cancer Center; State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine, No. 651 Dongfeng Road East, Guangzhou 510060, China.

: Nimotuzumab is a humanized anti-epidermal growth factor receptor (EGFR) antibody that has shown preclinical and clinical anticancer activity in cerebral glioblastoma multiforme (GBM). We conducted a phase II, single-arm, multicenter clinical trial to evaluate the benefit of adding nimotuzumab to current standard chemo-radiotherapy for patients with GBM with positive EGFR expression. : Newly diagnosed patients with histologically proven single supratentorial GBM and epidermal growth factor receptor (EGFR) positive expressions were recruited. Read More

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http://dx.doi.org/10.7150/jca.30123DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6603389PMC
June 2019
5 Reads

Association of respiratory viruses with serum metabolome in infants with severe bronchiolitis.

Pediatr Allergy Immunol 2019 12 18;30(8):848-851. Epub 2019 Jul 18.

Department of Emergency Medicine, Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA.

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http://dx.doi.org/10.1111/pai.13101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6906233PMC
December 2019
23 Reads
3.397 Impact Factor

Duplex real-time RT-PCR assay for detection and subgroup-specific identification of human respiratory syncytial virus.

J Virol Methods 2019 09 7;271:113676. Epub 2019 Jun 7.

Respiratory Viruses Branch, Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, GA, United States. Electronic address:

Human respiratory syncytial virus (HRSV) is a leading cause of acute respiratory illness in young children worldwide. Reliable detection and identification of HRSV subgroup A and B infections are essential for accurate disease burden estimates in anticipation of licensure of novel HRSV vaccines and immunotherapies. To ensure continued reliability, molecular assays must remain current with evolving virus strains. Read More

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http://dx.doi.org/10.1016/j.jviromet.2019.113676DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7172218PMC
September 2019
9 Reads

Genetic identification of newborns in Peru: A pilot study.

Rev Chil Pediatr 2019 ;90(1):26-35

Centro Nacional de Salud Pública, Instituto Nacional de Salud, Lima, Perú.

Objective: To determine the feasibility of genetic identification in a group of newborns from a public hospital in Lima, Peru.

Material And Method: Descriptive cross-sectional study, carried out by the National Registry of Identification and Civil Status of Peru, on live newborns and their mothers, from the Carlos Lanfranco La Hoz Hospital (Puente Piedra, Lima) during January. 2015. Read More

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http://dx.doi.org/10.32641/rchped.v90i1.730DOI Listing
December 2019
4 Reads

Clinical characteristics and outcomes of respiratory syncytial virus infection in pregnant women.

Vaccine 2019 06 10;37(26):3464-3471. Epub 2019 May 10.

Departments of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, United States; Pediatrics, Baylor College of Medicine, Houston, TX 77030, United States. Electronic address:

Objective: To describe the clinical presentation and laboratory diagnosis of pregnant women with respiratory syncytial virus (RSV) infection.

Methods: Pregnant women in their second and third trimester were enrolled during the course of routine prenatal care visits when they were asymptomatic within the preceding two weeks (healthy controls) or when they reported symptoms of acute respiratory illness (ARI) of ≤7 days of duration (cases). Clinical outcomes were assessed at enrollment and two weeks after. Read More

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http://dx.doi.org/10.1016/j.vaccine.2019.04.098DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7126758PMC
June 2019
11 Reads

Trichoscopy in the Differential Diagnosis of Pseudonits.

Skin Appendage Disord 2019 Apr 3;5(3):142-145. Epub 2019 Jan 3.

Dermatology Clinic, University of Catania, Catania, Italy.

Aim: The purpose of the study was to describe the trichoscopic features of pseudonits and to assess the usefulness of trichoscopy in their differential diagnosis.

Methods: A retrospective study was performed on those patients seen for the suspicion of head or pubic lice and who underwent trichoscopy with polarized light at ×10 magnification for a more accurate diagnosis. Forty-two patients (28 males/14 females, mean age: 34. Read More

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http://dx.doi.org/10.1159/000493741DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6489062PMC
April 2019
15 Reads

White Piedra: Clinical, Mycological, and Therapeutic Experience of Fourteen Cases.

Skin Appendage Disord 2019 Apr 13;5(3):135-141. Epub 2018 Dec 13.

Private practice, Culiacán, Mexico.

Background: White piedra (WP) is an asymptomatic superficial mycosis that affects the hair stems, forming whitish nodules caused by various species of the genus .

Objective: To present a case series of WP of the head, its epidemiological data, as well as clinical, mycological, and therapeutic experience.

Methods: We conducted a 12-year retrospective and observational study of WP cases tested by dermoscopy, mycological study, and the identification of species through morphology, biochemistry, and proteomics (matrix-assisted laser desorption/ionization time-of-flight mass spectrometry). Read More

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http://dx.doi.org/10.1159/000493374DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6489071PMC
April 2019
11 Reads

Remote Laboratory Management: Respiratory Virus Diagnostics.

J Vis Exp 2019 04 6(146). Epub 2019 Apr 6.

Baylor Global Health, Baylor College of Medicine; Department of Medicine, Baylor College of Medicine;

An uptick in recent pandemics (Ebola, Zika, MERS, influenza, etc.) underlines the need for a more 'nimble,' coordinated response that addresses a multitude of issues ranging from transportation, access, facilities, equipment, and communication to provider training. To address this need, we have developed an innovative, scalable, logistics-enhanced, mobile, laboratory facility for emergencies and epidemics in resource-constrained global settings. Read More

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http://dx.doi.org/10.3791/59188DOI Listing
April 2019
11 Reads

A Rare Case of White Piedra Caused by in the Sub-Himalayan Region of North India.

Int J Trichology 2019 Mar-Apr;11(2):82-85

Department of Microbiology, IGMC, Shimla, Himachal Pradesh, India.

White piedra is a superficial fungal infection of the hair shaft, caused by , a noncandidal yeast characterized by the presence of numerous, discrete, asymptomatic nodules attached to the infected hair shafts. White piedra is considered a disease of tropical regions and occasionally reported from temperate countries. Although such as is well known to cause cutaneous infections, it has been reported as a co-isolate for white piedra along with . Read More

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http://www.ijtrichology.com/text.asp?2019/11/2/82/255697
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http://dx.doi.org/10.4103/ijt.ijt_25_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463451PMC
April 2019
22 Reads

Antigenic Site-Specific Competitive Antibody Responses to the Fusion Protein of Respiratory Syncytial Virus Were Associated With Viral Clearance in Hematopoietic Cell Transplantation Adults.

Front Immunol 2019 29;10:706. Epub 2019 Mar 29.

Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, United States.

Recent studies of human sera showed that the majority of the respiratory syncytial virus (RSV) neutralizing antibodies are directed against pre-fusion conformation of the fusion (F) protein of RSV and revealed the importance of pre-fusion antigenic site Ø specific antibodies. However, detailed analysis of multiple antigenic site-specific competitive antibody responses to RSV F protein and their contribution to virus clearance in humans are lacking. We prospectively enrolled a cohort of RSV infected hematopoietic cell transplantation (HCT) adults ( = 40). Read More

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http://dx.doi.org/10.3389/fimmu.2019.00706DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449644PMC
March 2019
9 Reads