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Demographic and clinical characteristics, and adverse reactions of people with overweight and obesity consumers of orlistat, attended by a call center (2009 – 2017).

Medwave 2018 Oct 16;17(6):e7288. Epub 2018 Oct 16.

Consulta Externa de Nutrición Clínica, Hospital Médica Sur, Tlalpan, México. Address: Puente de Piedra 150, Toriello Guerra, Tlalpan, Ciudad de México, México, CP: 14050. Email:

Introduction: Chronic diseases are on the rise and are associated with weight gain. Multidisciplinary strategies are required for its control.

Methods: The design was descriptive, observational and retrospective. Read More

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October 2018

Tumor growth rate of pancreatic serous cystadenomas: Endosonographic follow-up with volume measurement to predict cyst enlargement.

Pancreatology 2018 Nov 23. Epub 2018 Nov 23.

Gastroclinica WGO Training Center, Tibás, San José, Costa Rica.

Background: Serous cystadenomas are benign lesions of the pancreas. Usually they are diagnosed incidentally on cross-sectional imaging studies. Endosonography is a valuable tool in the diagnosis and follow-up of these cystic lesions. Read More

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November 2018

Natural variation in acyl editing is a determinant of seed storage oil composition.

Sci Rep 2018 Nov 26;8(1):17346. Epub 2018 Nov 26.

Department of Plant Science, Rothamsted Research, Harpenden, Hertfordshire, AL5 2JQ, UK.

Seeds exhibit wide variation in the fatty acid composition of their storage oil. However, the genetic basis of this variation is only partially understood. Here we have used a multi-parent advanced generation inter-cross (MAGIC) population to study the genetic control of fatty acid chain length in Arabidopsis thaliana seed oil. Read More

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November 2018

Health care costs and resource utilization for different asthma severity stages in Colombia: a claims data analysis.

World Allergy Organ J 2018 12;11(1):26. Epub 2018 Nov 12.

1Health Economics Research Group, University of Cartagena, Campus Piedra de Bolívar, Cartagena, Colombia.

Background: Asthma is one of the most common chronic respiratory conditions worldwide. Asthma-related economic burden has been reported in Latin America, but knowledge about its economic impact to the Colombian health care system and the influence of disease severity is lacking. This study estimated direct medical costs and health care resource utilization (HCRU) in patients with asthma according to severity in Colombia. Read More

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November 2018
3 Reads

Varenicline for long term smoking cessation in patients with COPD.

Pulm Pharmacol Ther 2018 Dec 3;53:116-120. Epub 2018 Nov 3.

Department of Experimental Medicine and Surgery, Chair of Respiratory Medicine, University of Rome 'Tor Vergata', Via Montpellier, 100133, Rome, Italy.

Background: Quitting smoking is key for patients with Chronic Obstructive Pulmonary Disease (COPD). Standard recommendations for quitting smoking are implemented for COPD as well. Varenicline Tartrate (VT) is the most effective drug to help quit smoking, but few studies have analysed its effectiveness. Read More

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December 2018
5 Reads

The characterization of asthma with blood eosinophilia in adults in Latin America.

J Asthma 2018 Nov 5:1-9. Epub 2018 Nov 5.

d Unidad de Investigación , Hospital Médica Sur , Puente de Piedra 150, Colonia Toriello Guerra , Ciudad de México , CP. 14050 , México.

Objective: To identify and characterize asthma with blood eosinophilia in adults.

Methods: This cross-sectional study consisted of 164 asthma patients, aged 18 years or older. Multivariate analyses by logistic regression were performed to identify clinical characteristics and biomarkers associated with asthma with blood eosinophilia (defined as asthma and a peripheral blood eosinophil count ≥400 cells/mm). Read More

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November 2018
11 Reads

Respiratory syncytial virus fusion nanoparticle vaccine immune responses target multiple neutralizing epitopes that contribute to protection against wild-type and palivizumab-resistant mutant virus challenge.

Vaccine 2018 Dec 30;36(52):8069-8078. Epub 2018 Oct 30.

Novavax, Inc., Gaithersburg, MD, USA. Electronic address:

Human respiratory syncytial virus (RSV) is the leading cause of severe lower respiratory tract infections in newborns, young children, elderly, and immune-compromised. The RSV fusion (F) glycoprotein is a major focus of vaccine development and the target of palivizumab (Synagis®) which is licensed as an immuno-prophylactic for use in newborn children at high risk of infection. However, clinical use of a narrowly targeted monoclonal antibodies leads to the generation of escape mutant strains that are fully resistant to neutralization by the antibody. Read More

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December 2018
1 Read

Impacto de la medicina nuclear en el diagnóstico y tratamiento del cáncer diferenciado de tiroides.

Gac Med Mex 2018 ;154(4):509-519

Departamento de Cirugía de Cabeza y Cuello. Secretaría de Salud, Instituto Nacional de Cancerología, Ciudad de México, México.

Los pacientes afectados por el cáncer diferenciado de tiroides habitualmente presentan un curso clínico favorable, ya que la piedra angular del tratamiento es la cirugía; a pesar de esto, algunos pueden desarrollar un ominoso desenlace, debido a las características clinico-patológicas de esta enfermedad. El tratamiento óptimo aún es controvertido, en especial respecto a la extensión de la cirugía, indicaciones de radioyodo y la supresión de la hormona estimulante de la tiroides. La correcta evaluación de los riesgos, antes y después de la cirugía, facilita un selectivo enfoque del tratamiento; destacando la relevancia de revisar el impacto de la medicina nuclear en la correcta evaluación, tratamiento y seguimiento de los pacientes que padecen esta neoplasia. Read More

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January 2018

Severe bronchiolitis profiles and risk of recurrent wheeze by age 3 years.

J Allergy Clin Immunol 2018 Sep 18. Epub 2018 Sep 18.

Department of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Mass.

Background: A better understanding of bronchiolitis heterogeneity might help clarify its relationship with the development of recurrent wheezing and asthma.

Objectives: We sought to identify severe bronchiolitis profiles using a clustering approach and to investigate for the first time their association with allergy/inflammatory biomarkers, nasopharyngeal microbiota, and development of recurrent wheezing by age 3 years.

Methods: We analyzed data from a prospective, 17-center US cohort study of 921 infants (age <1 year) hospitalized with bronchiolitis (2011-2014 winters) with posthospitalization follow-up. Read More

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September 2018
3 Reads
11.480 Impact Factor

Trichosporon inkin meningitis in Northeast Brazil: first case report and review of the literature.

BMC Infect Dis 2018 Sep 18;18(1):470. Epub 2018 Sep 18.

Centro de Ciências da Saúde, Laboratório de Micologia Médica e Molecular, Departamento de Análises Clínicas e Toxicológicas, Universidade Federal do Rio Grande do Norte, Rua Gal. Gustavo Cordeiro de Faria S/N, Petrópolis, Natal, Rio Grande do Norte, Brazil.

Background: Trichosporon species may colonize the skin, respiratory tract and gastrointestinal tract of human beings. The yeast is recognized as etiological agent of white piedra, a superficial mycosis. Nevertheless, immunocompromised hosts may develop invasive Trichosporonosis. Read More

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September 2018
1 Read

RSV Strains and Disease Severity.

J Infect Dis 2018 Sep 11. Epub 2018 Sep 11.

Department of Molecular Virology and Microbiology and Department of Pediatrics, Baylor College of Medicine, Houston, Texas.

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September 2018
4 Reads

Initiation of anti-retroviral therapy before pregnancy reduces the risk of infection-related hospitalization in HIV-exposed uninfected infants born in a high-income country.

Clin Infect Dis 2018 Sep 12. Epub 2018 Sep 12.

Institute for Medical Immunology, Université libre de Bruxelles, Charleroi, Belgium.

Background: Epidemiological studies conducted in low and high-income countries showed that infants exposed to maternal HIV but not infected themselves by the virus have a high risk of severe infections. Immune alterations during fetal life have been proposed as a possible mechanism.

Methods: This prospective study was conducted to assess the relative risk of hospitalization for infection in HIV-exposed uninfected (HEU) infants as compared to HIV-unexposed (HU) infants born in a high-income country (HIC). Read More

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September 2018
1 Read

The Risk of Serious Bacterial Infection in Febrile Infants 0-90 Days of Life with a Respiratory Viral Infection.

Pediatr Infect Dis J 2018 Aug 30. Epub 2018 Aug 30.

Department of Pediatrics, Baylor College of Medicine, Houston, TX.

Background: Molecular diagnostic methods enhance the sensitivity and broaden the spectrum of detectable respiratory viruses in febrile infants ≤90 days of life. We describe the occurrence of respiratory viruses in this population as well as the rates of serious bacterial infection (SBI) and respiratory viral co-infection with regard to viral characteristics.

Methods: This was a prospective observational cohort study performed in the emergency department that included previously healthy febrile infants ≤90 days of life. Read More

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August 2018
1 Read

Comparative study of the effects of osteoprotegerin and testosterone on bone quality in male orchidectomised rats.

Aging Male 2018 Aug 25:1-13. Epub 2018 Aug 25.

a Department of Biochemical Research , Institute of Sanitary Research Fundación Jiménez Díaz , Madrid , Spain.

Aim: The aim of this work is to compare the effects of osteoprotegerin (OPG) and testosterone on bone quality in a model of orchidectomised (ORX) rats.

Methods: Three-month-old ORX or SHAM operated groups (n = 15 each group) were used. The SHAM and ORX groups received saline. Read More

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August 2018
4 Reads

Let's walk! Age reattribution and physical activity among older Hispanic/Latino adults: results from the ¡Caminemos! Randomized trial.

BMC Public Health 2018 Aug 3;18(1):964. Epub 2018 Aug 3.

David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.

Background: Many older Hispanics/Latinos are physically inactive and suffer the harmful health consequences associated with prolonged periods of inactivity. Negative age attributions that equate getting older with "slowing down" reinforce this inactive behavior. We implemented a community-based exercise intervention among insufficiently active older Hispanics/Latinos with a randomized trial of an attribution-retraining program, ¡Caminemos! (Let's Walk!), and measured the effect of the program on walking behavior. Read More

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August 2018
1 Read

Rhinovirus Species in Children with Severe Bronchiolitis: Multicenter Cohort Studies in the US and Finland.

Pediatr Infect Dis J 2018 Jul 11. Epub 2018 Jul 11.

the Department of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA (KH, LT, CAC) Department of Paediatrics and Adolescent Medicine, Turku University Hospital and University of Turku, Turku, Finland (TJ, LT) Departments of Pediatrics and Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA (YAB, JEG) Department of Medicine, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA (JMM) Departments of Molecular Virology and Microbiology and Pediatrics, Baylor College of Medicine, Houston, Texas, USA (PAP).

In this analysis of two prospective multi-center, multi-year cohorts of children hospitalized for bronchiolitis in the US and Finland, 306 rhinovirus infections were genotyped. Rhinovirus-A and -C species were predominant in the US study while rhinovirus-C species was predominant in the Finland study. In both cohorts, there were no significant between-species differences in clinical characteristics, including acute severity measures. Read More

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July 2018
1 Read
2.720 Impact Factor

The respiratory syncytial virus vaccine landscape: lessons from the graveyard and promising candidates.

Lancet Infect Dis 2018 Oct 18;18(10):e295-e311. Epub 2018 Jun 18.

Laboratory of Translational Immunology, University Medical Centre Utrecht, Utrecht, Netherlands; Department of Paediatrics, Wilhelmina Children's Hospital, University Medical Centre Utrecht, Utrecht, Netherlands; Respiratory Syncytial Virus Network (ReSViNET) Foundation, Zeist, Netherlands. Electronic address:

The global burden of disease caused by respiratory syncytial virus (RSV) is increasingly recognised, not only in infants, but also in older adults (aged ≥65 years). Advances in knowledge of the structural biology of the RSV surface fusion glycoprotein have revolutionised RSV vaccine development by providing a new target for preventive interventions. The RSV vaccine landscape has rapidly expanded to include 19 vaccine candidates and monoclonal antibodies (mAbs) in clinical trials, reflecting the urgency of reducing this global health problem and hence the prioritisation of RSV vaccine development. Read More

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October 2018
36 Reads

Fox parasites in pre-Columbian times: Evidence from the past to understand the current helminth assemblages.

Acta Trop 2018 Sep 11;185:380-384. Epub 2018 Jun 11.

Instituto Nacional de Antropología y Pensamiento Latinoamericano, Argentina; Universidad de Buenos Aires, Argentina.

This work aims to increase the information on the entero-parasitism in Holocene carnivores, by examining coprolites found in Patagonia. Molecular analysis was conducted following the Authenticity Criteria to Determine Ancient DNA sequences. The nucleotide sequences showed 99% of identity with the Control Region sequences of Lycalopex culpaeus (culpeo fox). Read More

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September 2018
2 Reads

Cases of white piedra of the hair on the American continent: a case report and a systematic literature review.

J Eur Acad Dermatol Venereol 2018 Jun 11. Epub 2018 Jun 11.

Facultad de Ciencias, Universidad Nacional de San Antonio Abad del Cusco (UNSAAC), Cusco, Peru.

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June 2018
2 Reads

Complications following pediatric cranioplasty after decompressive craniectomy: a multicenter retrospective study.

J Neurosurg Pediatr 2018 Sep 8;22(3):225-232. Epub 2018 Jun 8.

Department of Neurosurgery, Baylor College of Medicine, Houston, Texas.

OBJECTIVE In children, the repair of skull defects arising from decompressive craniectomy presents a unique set of challenges. Single-center studies have identified different risk factors for the common complications of cranioplasty resorption and infection. The goal of the present study was to determine the risk factors for bone resorption and infection after pediatric cranioplasty. Read More

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September 2018
16 Reads

Extensive Gastrointestinal Manifestations as the Main Relapsing Disease in Granulomatosis with Polyangiitis.

Dig Dis Sci 2018 10 4;63(10):2810-2812. Epub 2018 Jun 4.

Primary Systemic Vasculitides Clinic, Instituto Nacional de Enfermedades Respiratorias, Calzada de Tlalpan 4502, Col. Sección XVI, Tlalpan, C.P. 14080, Mexico City, Mexico.

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October 2018
18 Reads
2.550 Impact Factor

Nasopharyngeal CCL5 in infants with severe bronchiolitis and risk of recurrent wheezing: A multi-center prospective cohort study.

Clin Exp Allergy 2018 Aug 4;48(8):1063-1067. Epub 2018 Jun 4.

Department of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

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August 2018
2 Reads

Update on Omalizumab for Urticaria: What's New in the Literature from Mechanisms to Clinic.

Curr Allergy Asthma Rep 2018 May 9;18(5):33. Epub 2018 May 9.

Grupo de Alergología Clínica y Expermiental, IPS Universitaria, Universidad de Antioquia, Medellín, Colombia.

Purpose Of Review: Since omalizumab has been approved for urticaria, numerous randomized and real-life observational trials have been published. We reviewed the period January 2017-February 2018.

Recent Findings: Omalizumab is effective for the control of urticaria recalcitrant to antihistamines in different populations globally. Read More

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May 2018
5 Reads

A Cross-sectional Surveillance Study of the Frequency and Etiology of Acute Respiratory Illness Among Pregnant Women.

J Infect Dis 2018 Jul;218(4):528-535

Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas.

Background: Other than influenza, little is known about the consequences of viral acute respiratory illness (ARI) on pregnant women and fetuses. Our objectives were to determine the frequency of ARI due to respiratory viruses and the associated clinical outcomes during pregnancy.

Methods: Pregnant women in their second or third trimester were enrolled if they reported having symptoms of ARI or were healthy within the preceding 2 weeks. Read More

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July 2018
1 Read

The role of the gut microbiota in the pathology and prevention of liver disease.

J Nutr Biochem 2018 Oct 16;60:1-8. Epub 2018 Mar 16.

Translational Research Unit, Medica Sur Clinic & Foundation, Puente de Piedra 150, Toriello Guerra Tlalpan, C.P. 14050, Mexico City, Mexico. Electronic address:

Several microorganisms belonging to the intestinal microbiota act in an ecosystem responsible for maintaining the homeostasis and vital functions of human beings. From birth to old age the diversity of the intestinal microbiota may change due to environmental factors such as nutrition, immunity, diseases or the use of antibiotics leading to dysbiosis. Improvement in microbiota diversity can be achieved by modifying related risk factors through changes in lifestyle and a healthy diet. Read More

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October 2018
6 Reads
3.794 Impact Factor

The impact of exercise on depressive symptoms in older Hispanic/Latino adults: results from the '¡Caminemos!' study.

Aging Ment Health 2018 Apr 2:1-6. Epub 2018 Apr 2.

c Department of Medicine , David Geffen School of Medicine at UCLA and VA Greater Los Angeles Geriatric Research Education and Clinical Center , Los Angeles , CA , United States.

Objectives: We examined the prospective effects of an evidence-based exercise intervention on depressive symptoms in older Hispanics/Latinos and the potential synergistic effects (if any) of an attribution-retraining component to counter negative ascriptions to the aging process.

Method: We analyzed baseline, 1-, 12-, 24-month data collected from Hispanics/Latinos ≥ 60 years participating in an exercise intervention ("¡Caminemos!") across 27 senior centers (N = 572). All participants were given 4 weekly 1-hour group-based exercise classes targeting strength training, endurance, balance and flexibility. Read More

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April 2018
1 Read

Fungal diseases in children and adolescents in a referral centre in Bogota, Colombia.

Mycoses 2018 Aug 13;61(8):543-548. Epub 2018 Jun 13.

Dermatology Resident, Fundación Universitaria Sanitas, Centro Dermatológico Federico Lleras Acosta, E.S.E., Bogotá, Colombia.

A cross-sectional descriptive study was conducted at a dermatology referral centre in Bogotá, to estimate the frequencies and aetiologies of mycoses in the population under 18 years of age attending the medical mycology laboratory over a 13-year period (2000-2012). A total of 1337 samples from 1221 patients were evaluated, involving direct examination and culture for 1279 samples, direct examination alone for 50 and culture alone for 8. During the study period, dermatophytosis was diagnosed via culture in 537 cases (40. Read More

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August 2018
6 Reads

Wildlife-vehicle collisions in Lanzarote Biosphere Reserve, Canary Islands.

PLoS One 2018 21;13(3):e0192731. Epub 2018 Mar 21.

Department of Evolutionary Ecology, Estación Biológica de Doñana (CSIC), Avda. Américo Vespucio 26, Seville, Spain.

Insular wildlife is more prone to extinction than their mainland relatives. Thus, a basic understanding of non-natural mortality sources is the first step in the development of conservation management plans. The Canary Islands are an important tourist destination due to their unique climate and rich scenery and biodiversity. Read More

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Toxicity of atrazine- and glyphosate-based formulations on Caenorhabditis elegans.

Ecotoxicol Environ Saf 2018 Jul 20;156:216-222. Epub 2018 Mar 20.

Environmental and Computational Chemistry Group, Zaragocilla Campus. School of Pharmaceutical Sciences. University of Cartagena, Cartagena 130015, Colombia. Electronic address:

Atrazine and Glyphosate are herbicides massively used in agriculture for crop protection. Upon application, they are available to the biota in different ecosystems. The aim of this research was to evaluate the toxicity of Glyphosate and Atrazine based formulations (GBF and ABF, respectively). Read More

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Clinical and echocardiographic factors associated with mitral plasticity in patients with chronic inferior myocardial infarction.

Eur Heart J Cardiovasc Imaging 2018 05;19(5):508-515

Department of Out patients Care, Echocardiography, Nuclear medicine National Instituto of Cardiology Ignacio Chávez, Juan Badiano No.1, Colonia Sección XVI, Tlalpan, Mexico City 14080, Mexico.

Aims: Ischaemic mitral regurgitation (IMR) is consequence of left ventricular (LV) remodelling after myocardial infarction. In some cases, the mitral valve enlarges to compensate for LV remodelling and tenting, improving its coaptation; a process termed 'plasticity'. We sought to identify clinical and echocardiographic factors associated with plasticity in patients with chronic inferior myocardial infarction (CII). Read More

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May 2018
5 Reads

Comparison of Palivizumab-Like Antibody Binding to Different Conformations of the RSV F Protein in RSV-Infected Adult Hematopoietic Cell Transplant Recipients.

J Infect Dis 2018 Mar;217(8):1247-1256

Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX.

Background: Most respiratory syncytial virus (RSV) vaccine candidates include fusion (F) protein in different conformations. Antigenic site II found in the different F conformations is the target of palivizumab, the only US Food and Drug Administration approved monoclonal antibody (mAb). Serum palivizumab-like antibody (PLA) is a potential serologic correlate of immunity. Read More

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March 2018
12 Reads

Long-term pubic dermatitis diagnosed as white piedra.

Authors:
James Landero

Cutis 2017 Dec;100(6):448-450

Premier Dermatology, Abilene, Texas, USA.

The case of a 58-year-old man with a pruritic rash involving the pubic area that had been undiagnosed for 30 years is presented. At least 15 different primary care physicians and dermatologists evaluated the patient during this time period. Multiple treatments were unsuccessful and a definitive diagnosis was not rendered. Read More

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December 2017
1 Read

Establishing Correlates of Protection for Vaccine Development: Considerations for the Respiratory Syncytial Virus Vaccine Field.

Viral Immunol 2018 03 16;31(2):195-203. Epub 2018 Jan 16.

6 Department of Molecular Virology and Microbiology, Baylor College of Medicine , Houston, Texas.

Correlates of protection (CoPs) can play a significant role in vaccine development by assisting the selection of vaccine candidates for clinical trials, supporting clinical trial design and implementation, and simplifying tests of vaccine modifications. Because of this important role in vaccine development, it is essential that CoPs be defined by well-designed immunogenicity and efficacy studies, with attention paid to benefits and limitations. The respiratory syncytial virus (RSV) field is unique in that a great deal of information about the humoral response is available from basic research and clinical studies. Read More

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March 2018
14 Reads

The association between anterior nares and nasopharyngeal microbiota in infants hospitalized for bronchiolitis.

Microbiome 2018 01 3;6(1). Epub 2018 Jan 3.

Department of Medicine, Boston Children's Hospital, Boston, MA, USA.

Background: The airway microbiome is a subject of great interest for the study of respiratory disease. Anterior nare samples are more accessible than samples from deeper within the nasopharynx. However, the correlation between the microbiota found in the anterior nares and the microbiota found within the nasopharynx is unknown. Read More

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January 2018
7 Reads

Respiratory Syncytial Virus and Rhinovirus Bronchiolitis Are Associated With Distinct Metabolic Pathways.

J Infect Dis 2018 Mar;217(7):1160-1169

Department of Medicine, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts.

Background: Bronchiolitis, the leading cause of hospitalization among infants in the United States, is most commonly caused by respiratory syncytial virus (RSV), followed by rhinovirus (RV). Conventional perception is that bronchiolitis is a single entity, albeit with different viral etiologies and degrees of severity.

Methods: We conducted a cross-sectional study of nasopharyngeal aspirates from 106 infants hospitalized with bronchiolitis due to either RSV only (80 patients) or RV only (26 patients). Read More

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March 2018
8 Reads
1 Citation
6.000 Impact Factor

RSV vs. rhinovirus bronchiolitis: difference in nasal airway microRNA profiles and NFκB signaling.

Pediatr Res 2018 Mar 17;83(3):606-614. Epub 2018 Jan 17.

Division of Emergency Medicine, Children's National Health System, Washington, DC.

BackgroundAlthough rhinovirus infection is associated with increased risks of acute and chronic respiratory outcomes during childhood compared with respiratory syncytial virus (RSV), the underlying mechanisms remain unclear. We aimed to determine the differences in nasal airway microRNA profiles and their downstream effects between infants with rhinovirus and RSV bronchiolitis.MethodsAs part of a multicenter cohort study of infants hospitalized for bronchiolitis, we examined nasal samples obtained from 16 infants with rhinovirus and 16 infants with RSV. Read More

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March 2018
14 Reads
2.310 Impact Factor

White piedra, black piedra, tinea versicolor, and tinea nigra: contribution to the diagnosis of superficial mycosis.

An Bras Dermatol 2017 May-Jun;92(3):413-416

Dermatology Clinic, Hospital da Irmandade da Santa Casa de Misericórdia de São Paulo - São Paulo (SP) Brazil.

Superficial mycoses are fungal infections restricted to the stratum corneum and to the hair shafts, with no penetration in the epidermis; they are: white piedra, black piedra, tinea versicolor, and tinea nigra. This study presents images of mycological tests performed in the laboratory, as well as exams performed at the authors office, in order to improve the dermatologist's knowledge about the diagnosis of these dermatoses, which are common in many countries. Read More

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January 2018
11 Reads

Analysis of the influence of the T393C polymorphism of the GNAS gene on the clinical expression of primary hyperparathyroidism.

Endocrinol Diabetes Nutr 2017 Dec 18;64(10):524-530. Epub 2017 Oct 18.

Servicio de Endocrinología, Hospital Universitario "Marqués de Valdecilla", Instituto de Investigación "Marqués de Valdecilla" (IDIVAL), Universidad de Cantabria, Avda. de Valdecilla s/n, Santander 39008, Cantabria, Spain.

Background: The receptor of parathyroid hormone and parathyroid hormone-related-protein (PTH/PTHrp) is located in the cell membrane of target tissues - kidney and osteoblasts. It is a G protein-coupled-receptor whose Gα subunit is encoded by the GNAS gene. Our aim was to study whether the single nucleotide polymorphism (SNP) T393C of the GNAS gene is associated with renal stones, bone mineral density (BMD), or bone remodelling markers in primary hyperparathyroidism (PHPT). Read More

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December 2017
20 Reads

Effects of Cyclosporine, Tacrolimus, and Rapamycin on Osteoblasts.

Transplant Proc 2017 Nov;49(9):2219-2224

Bioquímica Investigación, Instituto de Investigación Sanitaria Fundación Jiménez Díaz, Madrid, Spain. Electronic address:

Purpose: One factor that can contribute to severe bone loss after transplantation is the direct action of immunosuppressants on bone cells. The aim of this work was to study the effects of cyclosporine (CsA), tacrolimus (FK-506), and rapamycin (RAPA) on the release of three local factors directly implicated in bone-remodeling regulation and apoptosis of human osteoblasts: interleukin (IL)-6, osteoprotegerin, and receptor activator of nuclear factor κβ (RANKL).

Basic Procedures: Human osteoblasts were obtained from five different patients who underwent orthopedic surgery. Read More

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November 2017
20 Reads

Noninvasive ventilation in hypercapnic chronic obstructive pulmonary disease.

Crit Care 2017 10 26;21(1):266. Epub 2017 Oct 26.

Department of Critical Care Medicine, Fundación Clínica Médica Sur, Mexico City, Mexico.

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October 2017
8 Reads

Respiratory Syncytial Virus Genotypes, Host Immune Profiles, and Disease Severity in Young Children Hospitalized With Bronchiolitis.

J Infect Dis 2017 Dec;217(1):24-34

Center for Vaccines and Immunity, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio.

Background: Data on how respiratory syncytial virus (RSV) genotypes influence disease severity and host immune responses is limited. Here, we characterized the genetic variability of RSV during 5 seasons, and evaluated the role of RSV subtypes, genotypes, and viral loads in disease severity and host transcriptional profiles.

Methods: A prospective, observational study was carried out, including a convenience sample of healthy infants hospitalized with RSV bronchiolitis. Read More

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December 2017
19 Reads

Listening to Relaxing Music Improves Physiological Responses in Premature Infants: A Randomized Controlled Trial.

Adv Neonatal Care 2018 Feb;18(1):58-69

Mind, Brain, and Behavior Research Center (CIMCYC), University of Granada, Granada, Spain (Mr Caparros-Gonzalez, Dr Diaz-Piedra, and Dr Buela-Casal); Faculty of Psychology, University of Balearic Islands, Balearic Islands, Spain (Mr de la Torre-Luque); School of Computer Science, University of Malaga, Malaga, Spain (Dr Vico); and Gynecology and Obstetric Department, Hospital Poniente, El Ejido, Almeria, Spain (Mr Caparros-Gonzalez).

Background: Premature infants are exposed to high levels of noise in the neonatal intensive care unit (NICU).

Purpose: This study evaluated the effect of a relaxing music therapy intervention composed by artificial intelligence on respiratory rate, systolic and diastolic blood pressure, and heart rate.

Methods: A double-blind, randomized, controlled trial was conducted in the NICUs of 2 general public hospitals in Andalusia, Spain. Read More

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February 2018
16 Reads

Debates in Allergy Medicine: Allergy skin testing cannot be replaced by molecular diagnosis in the near future.

World Allergy Organ J 2017 19;10(1):32. Epub 2017 Sep 19.

Institute of Medical Statistics and Epidemiology, Faculty of Medicine, University of Cologne, Cologne, Germany.

Percutaneous skin prick tests (SPT) have been considered the preferred method for confirming IgE-mediated sensitization. This reliable and minimally invasive technique correlates with in vivo challenges, has good reproducibility, is easily quantified, and allows analyzing multiple allergens simultaneously. Potent extracts and a proficient tester improve its accuracy. Read More

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September 2017
30 Reads

Local Versus Global Enterovirus (EV) Surveillance: A Discussion for the Need for Active Surveillance to Guide EV-A71 Vaccines.

J Infect Dis 2017 Dec;216(11):1337-1339

Department of Molecular Virology and Microbiology, and Pediatrics, Baylor College of Medicine, Houston, Texas.

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December 2017
16 Reads

Flamingos and drought as drivers of nutrients and microbial dynamics in a saline lake.

Sci Rep 2017 Sep 22;7(1):12173. Epub 2017 Sep 22.

Departamento de Ecología e Instituto del Agua, Universidad de Granada, 18071, Granada, Spain.

Waterbird aggregations and droughts affect nutrient and microbial dynamics in wetlands. We analysed the effects of high densities of flamingos on nutrients and microbial dynamics in a saline lake during a wet and a dry hydrological year, and explored the effects of guano on prokaryotic growth. Concentrations of dissolved organic carbon, total phosphorus and total nitrogen in the surface waters were 2-3 fold higher during the drought and were correlated with salinity. Read More

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September 2017
19 Reads

Immunologic Profiling of Human Metapneumovirus for the Development of Targeted Immunotherapy.

J Infect Dis 2017 Sep;216(6):678-687

Center for Cell and Gene Therapy, Baylor College of Medicine, Texas Children's Hospital, and Houston Methodist Hospital.

Human metapneumovirus (hMPV) is a respiratory virus detected in ≥9% of allogeneic hematopoietic stem cell transplant (HSCT) recipients, in whom it can cause significant morbidity and mortality. Given the lack of effective antivirals, we investigated the potential for immunotherapeutic intervention, using adoptively transferred T cells. Thus, we characterized the cellular immune response to the virus and identified F, N, M2-1, M, and P as immunodominant target antigens. Read More

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September 2017
13 Reads

Changes in Radial Artery Pulse Pressure During a Fluid Challenge Cannot Assess Fluid Responsiveness in Patients With Septic Shock.

J Intensive Care Med 2017 Jan 1:885066617732291. Epub 2017 Jan 1.

1 Department of Critical Care Medicine, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Vasco de Quiroga 15, Mexico City, Mexico.

Background: Arterial blood pressure is the most common variable used to assess the response to a fluid challenge in routine clinical practice. The aim of this study was to evaluate the accuracy of the change in the radial artery pulse pressure (rPP) to detect the change in cardiac output after a fluid challenge in patients with septic shock.

Methods: Prospective observational study including 35 patients with septic shock in which rPP and cardiac output were measured before and after a fluid challenge with 400 mL of crystalloid solution. Read More

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January 2017
5 Reads

Identifying Gaps in Respiratory Syncytial Virus Disease Epidemiology in the United States Prior to the Introduction of Vaccines.

Clin Infect Dis 2017 Sep;65(6):1020-1025

Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.

Respiratory syncytial virus (RSV) causes lower respiratory tract illness frequently. No effective antivirals or vaccines for RSV are approved for use in the United States; however, there are at least 50 vaccines and monoclonal antibody products in development, with those targeting older adults and pregnant women (to protect young infants) in phase 2 and 3 clinical trials. Unanswered questions regarding RSV epidemiology need to be identified and addressed prior to RSV vaccine introduction to guide the measurement of impact and future recommendations. Read More

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September 2017
28 Reads

Stigma-Stop: A Serious Game against the Stigma toward Mental Health in Educational Settings.

Front Psychol 2017 21;8:1385. Epub 2017 Aug 21.

Department of Education, University of AlmeríaAlmería, Spain.

This paper presents the results from the application of a serious game called Stigma-Stop among a group of high school students with the aim of reducing the stigma toward mental illnesses. The video game features characters with various mental disorders (schizophrenia, depression, bipolar disorder, and panic disorder with agoraphobia) and provides information about these problems. Additionally, the game asks players about whether they have ever felt the same as the characters, if they believe the characters are psychologically well, and if they think they could help these individuals. Read More

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August 2017
21 Reads