12,097 results match your criteria Pick Disease


Pneumolabyrinth and Recurrent Paroxysmal Positional Vertigo After Traumatic Stapes Fracture.

Ann Otol Rhinol Laryngol 2018 Dec 17:3489418819553. Epub 2018 Dec 17.

3 Institute of Otolaryngology, Department of Neurosciences, Padova University, Padova, Italy.

Objectives:: The development of pneumolabyrinth without previous head trauma is a rare event; the associated symptoms may be nonspecific, and they can simulate various cochleo-vestibular pathological entities. The aim of the present study is to describe one of these rare occurrences, characterized by a peculiar onset.

Methods:: We report a case of stapes fracture secondary to ear pick penetration into the middle ear with a pneumolabyrinth that caused a recurrent paroxysmal positional vertigo (PPV) mimicking a canalolithiasis. Read More

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December 2018

Enrichment of pathogenic variants in genes associated with inborn errors of metabolism in psychiatric populations.

Am J Med Genet B Neuropsychiatr Genet 2018 Dec 16. Epub 2018 Dec 16.

Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.

Many genetic conditions can mimic mental health disorders, with psychiatric symptoms that are difficult to treat with standard psychotropic medications. This study tests the hypothesis that psychiatric populations are enriched for pathogenic variants associated with selected inborn errors of metabolism (IEMs). Using next-generation sequencing, 2046 psychiatric patients were screened for pathogenic variants in genes associated with four IEMs, Niemann-Pick disease type C (NPC), Wilson disease (WD), homocystinuria (HOM), and acute intermittent porphyria (AIP). Read More

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December 2018

Optimal duration and predictors of diagnostic utility of patient-activated ambulatory ECG monitoring.

Heart Asia 2018 24;10(2):e011061. Epub 2018 Nov 24.

Department of Cardiology, National University Heart Centre Singapore, Singapore, Singapore.

Objective: We studied the optimal duration of ambulatory event monitors for symptomatic patients and the predictors of detected events.

Methods: Patients with palpitations or dizziness received a patient-activated handheld event monitor which records 30 s single-lead ECG strips. Patients were monitored in an ambulatory setting for a range of 1-4 weeks and ECG strips interpreted by five independent electrophysiologists. Read More

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November 2018

Identification of Potential Prognostic Genes for Neuroblastoma.

Front Genet 2018 29;9:589. Epub 2018 Nov 29.

College of Computer Science and Technology, Jilin University, Changchun, China.

Neuroblastoma (NB), the most common pediatric solid tumor apart from brain tumor, is associated with dismal long-term survival. The aim of this study was to identify a gene signature to predict the prognosis of NB patients. GSE49710 dataset from the Gene Expression Omnibus (GEO) database was downloaded and differentially expressed genes (DEGs) were analyzed using R package "limma" and SPSS software. Read More

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November 2018

Mid-Luteal 17-OH Progesterone Levels in 614 Women Undergoing IVF-Treatment and Fresh Embryo Transfer-Daytime Variation and Impact on Live Birth Rates.

Front Endocrinol (Lausanne) 2018 29;9:690. Epub 2018 Nov 29.

The Fertility Clinic, Herlev University Hospital, Herlev, Denmark.

Corpus luteum (CL) produces progesterone (P) and 17-OH progesterone (17-OH P) during the luteal phase. Contrary to P, 17-OH P is not supplied as part of the luteal phase support following IVF-treatment. Therefore, measuring endogenous serum 17-OH P levels may more accurately reflect the CL function compared to monitoring serum P concentrations. Read More

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November 2018

Total Intravenous Anesthetic Versus Inhaled Anesthetic: Pick Your Poison.

Anesth Analg 2019 Jan;128(1):13-15

University of North Carolina School of Medicine, Chapel Hill, North Carolina.

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January 2019

A study in a Polish ataxia cohort indicates genetic heterogeneity and points to MTCL1 as a novel candidate gene.

Clin Genet 2018 Dec 11. Epub 2018 Dec 11.

Department of Medical Genetics, Medical University of Warsaw, Warsaw, Poland.

Inherited ataxias are a group of highly heterogeneous, complex neurological disorders representing a significant diagnostic challenge in clinical practice. We performed next generation sequencing analysis in 10 index cases with unexplained progressive cerebellar ataxia of suspected autosomal recessive inheritance. A definite molecular diagnosis was obtained in 5/10 families and included the following diseases: autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS), POLR3B-related hypomyelinating leukodystrophy, primary coenzyme Q10 deficiency type 4, Niemann-Pick disease type C1 and SYNE1-related ataxia. Read More

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December 2018

Microneedling by dermapen and glycolic acid peel for the treatment of acne scars: Comparative study.

J Cosmet Dermatol 2018 Dec 9. Epub 2018 Dec 9.

Faculty of Medicine, Zagazig University, Zagazig, Egypt.

Background: Many methods have been performed to achieve a satisfying outcome in acne scars but some of them were high cost and also were associated with low results and some complications.

Objectives: To evaluate and compare the efficacy and safety therapy of glycolic acid (GA) peel, microneedling with dermapen and a combination of both procedures in treatment of atrophic acne scars.

Patents And Methods: This study was conducted on 30 patients suffering from acne scars. Read More

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December 2018
2 Reads

Patient Perceptions of Electronic Prescriptions in Belgium: An Exploratory Policy Analysis.

Pharmacy (Basel) 2018 Dec 8;6(4). Epub 2018 Dec 8.

Laboratory of Physiopharmacology, University of Antwerp, Universiteitsplein 1, B-2610 Antwerp, Belgium.

In today's world, digitalization and automation are ubiquitous and different countries have different strategies for implementing information technology in health care. In Belgium, these plans include the dematerialization of prescriptions, following the implementation of a system of electronic prescribing. In the light of these changes, we studied the attitudes of patients toward a paperless prescription. Read More

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December 2018

In vitro lipid transfer assays of phosphatidylinositol transfer proteins provide insight into the in vivo mechanism of ligand transfer.

Biochim Biophys Acta Biomembr 2018 Dec 10. Epub 2018 Dec 10.

Department of Chemistry and Centre for Biotechnology, Brock University, St. Catharines, Ontario L2A 3S1, Canada. Electronic address:

Fluorescence resonance energy transfer (FRET) assays and membrane binding determinations were performed using three phosphatidylinositol transfer proteins, including the yeast Sec14 and two mammalian proteins PITPα and PITPβ. These proteins were able to specifically bind the fluorescent phosphatidylcholine analogue NBD-PC ((2-(12-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)dodecanoyl-1-hexadecanoyl-sn-glycero-3-phosphocholine)) and to transfer it to small unilamellar vesicles (SUVs). Rate constants for transfer to vesicles comprising 100% PC were slower for all proteins than when increasing percentages of phosphatidylinositol were incorporated into the same SUVs. Read More

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December 2018
1 Read

Decoding motor neuron activity from epimysial thin-film electrode recordings following targeted muscle reinnervation.

J Neural Eng 2018 Nov 1. Epub 2018 Nov 1.

Department of Bioengineering, Imperial College London, London, SW7 2AZ, UNITED KINGDOM OF GREAT BRITAIN AND NORTHERN IRELAND.

Objective: Surface electromyography (EMG) is currently used as a control signal for active prostheses in amputees who underwent targeted muscle reinnervation (TMR) surgery. Recent research has shown that it is possible to access the spiking activity of spinal motor neurons from multi-channel surface EMG. In this study, we propose the use of multi-channel epimysial EMG electrodes as an interface for decoding motor neurons activity following TMR. Read More

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November 2018
2 Reads

Combination of high-frequency SSVEP-based BCI and computer vision for controlling a robotic arm.

J Neural Eng 2018 Dec 3. Epub 2018 Dec 3.

Department of Biomedical Engineering School of Medicine, Tsinghua University, Beijing 100084, PR CHINA, Beijing, CHINA.

Objective: Recent attempts in developing brain-computer interface (BCI)-controlled robots have shown the potential of this area in the field of assistive robots. However, implementing the process of objects picking and placing using BCI-controlled robotic arm still remains challenging. BCI performance, system portability, and user comfortableness need to be further improved. Read More

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December 2018

Positive airway pressure for sleep-disordered breathing in acute quadriplegia: a randomised controlled trial.

Thorax 2018 Dec 11. Epub 2018 Dec 11.

Department of Respiratory and Sleep Medicine, Royal North Shore Hospital, St Leonards, New South Wales, Australia.

Rationale: Highly prevalent and severe sleep-disordered breathing caused by acute cervical spinal cord injury (quadriplegia) is associated with neurocognitive dysfunction and sleepiness and is likely to impair rehabilitation.

Objective: To determine whether 3 months of autotitrating CPAP would improve neurocognitive function, sleepiness, quality of life, anxiety and depression more than usual care in acute quadriplegia.

Methods And Measurements: Multinational, randomised controlled trial (11 centres) from July 2009 to October 2015. Read More

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December 2018

Edge-Functionalized Graphene Nanoplatelets as Metal-Free Electrocatalysts for Dye-Sensitized Solar Cells.

Adv Mater 2018 Dec 9:e1804440. Epub 2018 Dec 9.

Center for Dimension-Controllable Organic Frameworks, School of Energy and Chemical Engineering, Ulsan National Institute of Science and Technology (UNIST), 50 UNIST, Ulsan, 44919, Korea.

A scalable and low-cost production of graphene nanoplatelets (GnPs) is one of the most important challenges for their commercialization. A simple mechanochemical reaction has been developed and applied to prepare various edge-functionalized GnPs (EFGnPs). EFGnPs can be produced in a simple and ecofriendly manner by ball milling of graphite with target substances (X = nonmetals, halogens, semimetals, or metalloids). Read More

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December 2018
1 Read

Lipid-induced lysosomal damage after demyelination corrupts microglia protective function in lysosomal storage disorders.

EMBO J 2018 Dec 7. Epub 2018 Dec 7.

Department of Molecular Neuropathology, Centro de Biología Molecular "Severo Ochoa" (CSIC-UAM), Madrid, Spain

Neuropathic lysosomal storage disorders (LSDs) present with activated pro-inflammatory microglia. However, anti-inflammatory treatment failed to improve disease pathology. We characterise the mechanisms underlying microglia activation in Niemann-Pick disease type A (NPA). Read More

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December 2018
10.434 Impact Factor

Circadian Expression of Migratory Factors Establishes Lineage-Specific Signatures that Guide the Homing of Leukocyte Subsets to Tissues.

Immunity 2018 Nov 27. Epub 2018 Nov 27.

Walter Brendel Centre of Experimental Medicine, University Hospital, Ludwig Maximilians University of Munich, BioMedical Centre, 82152 Planegg-Martinsried, Germany; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany; Department of Pathology and Immunology, Centre Médical Universitaire, University of Geneva, Switzerland. Electronic address:

The number of leukocytes present in circulation varies throughout the day, reflecting bone marrow output and emigration from blood into tissues. Using an organism-wide circadian screening approach, we detected oscillations in pro-migratory factors that were distinct for specific vascular beds and individual leukocyte subsets. This rhythmic molecular signature governed time-of-day-dependent homing behavior of leukocyte subsets to specific organs. Read More

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November 2018

Biodegradable thermomagnetically responsive soft untethered grippers.

ACS Appl Mater Interfaces 2018 Dec 10. Epub 2018 Dec 10.

Soft-robotic devices such as polymeric microgrippers offer the possibility for pick-and-place of fragile biological cargo in hard to reach conduits with potential applications in drug delivery, minimally invasive surgery and biomedical engineering. Previously, millimeter-sized self-folding thermomagnetically responsive soft-grippers have been designed, fabricated, and utilized for pick-and-place applications but there is the concern that such devices could get lost or left behind after their utilization in practical clinical applications in the human body. Consequently, strategies need to be developed to ensure that these soft-robotic devices are biodegradable so that they would disintegrate if left behind in the body. Read More

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December 2018
1 Read

Wafer-scale van der Waals heterostructures with ultraclean interfaces via the aid of viscoelastic polymer.

ACS Appl Mater Interfaces 2018 Dec 10. Epub 2018 Dec 10.

Two-dimensional (2D) van der Waals (vdW) heterostructures exhibit novel physical and chemical properties, allowing the development of unprecedented electronic, optical, and electrochemical devices. However, the construction of wafer-scale vdW heterostructures for practical applications is still limited due to the lack of well-established growth and transfer techniques. Herein, we report a method for the fabrication of wafer-scale 2D vdW heterostructures with ultraclean interface between layers via the aid of freestanding viscoelastic polymer support layer (VEPSL). Read More

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December 2018

Radiochemical synthesis and preclinical evaluation of Ga-labeled NODAGA-hydroxypropyl-beta-cyclodextrin (Ga-NODAGA-HPBCD).

Eur J Pharm Sci 2018 Dec 4;128:202-208. Epub 2018 Dec 4.

Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Debrecen, Nagyerdei St. 98, H-4032 Debrecen, Hungary. Electronic address:

A new renaissance started in the research and application of cyclodextrins a few years ago. 2-Hydroxypropyl-beta-cyclodextrin (HPBCD) is used in the formulation of drugs and recently orphan designation was granted for the treatment of Niemann-Pick disease, type C. HPBCD is considered to be safe, but the exact mechanism of action and side effects are not completely explained. Read More

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December 2018
2 Reads

Bladder hematoma: a complication from an oocyte retrieval procedure.

JBRA Assist Reprod 2018 Dec 6. Epub 2018 Dec 6.

Fertipraxis-Centro de Reprodução Humana- RJ, Brazil.

Introduction: More than one million fertilization cycles are performed every year. The incidence of serious complications associated with transvaginal oocyte pick-up is low, but the procedure is not risk-free. Risks are inherent to procedures in which thin needles and sharp instruments are introduced into the vaginal wall and ovarian capsule to access the ovaries. Read More

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December 2018
6 Reads

Examining the effectiveness of examination at 6-8 weeks for developmental dysplasia: testing the safety net.

Arch Dis Child 2018 Dec 5. Epub 2018 Dec 5.

Trauma and Orthopaedic Department, Ninewells Hospital, Dundee, UK.

Objective: The 'GP check' at 6-8 weeks forms part of the selective surveillance system for developmental dysplasia of the hip (DDH) in the UK. It is imperative to pick up DDH within the first months of life to allow for non-invasive treatment and the avoidance of surgery. We aim to investigate the effectiveness of hip examination at 6-8 weeks. Read More

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December 2018
1 Read

Proteasome lid bridges mitochondrial stress with Cdc53/Cullin1 NEDDylation status.

Redox Biol 2018 Nov 17;20:533-543. Epub 2018 Nov 17.

Department of Human Biology, The Faculty of Natural Sciences, University of Haifa, Haifa 3190500, Israel; Department of Biology and Environment, The Faculty of Natural Sciences, University of Haifa at Oranim, Tivon 3600600, Israel. Electronic address:

Cycles of Cdc53/Cullin1 rubylation (a.k.a NEDDylation) protect ubiquitin-E3 SCF (Skp1-Cullin1-F-box protein) complexes from self-destruction and play an important role in mediating the ubiquitination of key protein substrates involved in cell cycle progression, development, and survival. Read More

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November 2018
2 Reads

Non-destructive position measurement of coasting beam using Schottky signals.

Rev Sci Instrum 2018 Nov;89(11):113305

GSI Helmholtzzentrum für Schwerionenforschung, Planckstrasse 1, 64291 Darmstadt, Germany.

The beam position appears in the transverse Schottky signal spectra of coasting beams at revolution frequency and its harmonics. In this contribution, we utilize this signal for beam position monitoring using regular shoe-box monitors at heavy ion synchrotron GSI SIS-18. Position resolution below 1 mm at 1 kHz rate for 10 mA current was obtained. Read More

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November 2018
2 Reads

Comparison and assessment of family- and population-based genotype imputation methods in large pedigrees.

Genome Res 2018 Dec 4. Epub 2018 Dec 4.

Qatar Computing Research Institute, Hamad Bin Khalifa University, Doha, Qatar.

Genotype imputation is widely used in genome-wide association studies to boost variant density, allowing increased power in association testing. Many studies currently include pedigree data due to increasing interest in rare variants coupled with the availability of appropriate analysis tools. The performance of population-based (subjects are unrelated) imputation methods is well established. Read More

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December 2018
1 Read

A DNA nanomachine chemically resolves lysosomes in live cells.

Nat Nanotechnol 2018 Dec 3. Epub 2018 Dec 3.

Department of Chemistry, The University of Chicago, Chicago, IL, USA.

Lysosomes are multifunctional, subcellular organelles with roles in plasma membrane repair, autophagy, pathogen degradation and nutrient sensing. Dysfunctional lysosomes underlie Alzheimer's disease, Parkinson's disease and rare lysosomal storage diseases, but their contributions to these pathophysiologies are unclear. Live imaging has revealed lysosome subpopulations with different physical characteristics including dynamics, morphology or cellular localization. Read More

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December 2018
2 Reads

Influences of augmented reality head-worn display type and user interface design on performance and usability in simulated warehouse order picking.

Appl Ergon 2019 Jan 3;74:186-193. Epub 2018 Sep 3.

Department of Industrial and Systems Engineering, Virginia Tech, Blacksburg, VA, 24061, USA.

Limited information is available regarding the effective use of workplace head-worn displays (HWD), especially the choices of HWD types and user interface (UI) designs. We explored how different HWD types and UI designs affect perceived workload, usability, visual discomfort, and job performance during a simulated warehouse job involving order picking and part assembly. Sixteen gender-balanced participants completed the simulated job in all combinations of two HWD types (binocular vs. Read More

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January 2019
1 Read

A Comprehensive Approach to Powder Feedstock Characterization for Powder Bed Fusion Additive Manufacturing: A Case Study on AlSi7Mg.

Materials (Basel) 2018 Nov 27;11(12). Epub 2018 Nov 27.

REGAL Aluminum Research Center, Department of Mining and Materials Engineering, McGill University, Montreal, QC H3A 0C5, Canada.

In powder bed fusion additive manufacturing, the powder feedstock quality is of paramount importance; as the process relies on thin layers of powder being spread and selectively melted to manufacture 3D metallic components. Conventional powder quality assessments for additive manufacturing are limited to particle morphology, particle size distribution, apparent density and flowability. However, recent studies are highlighting that these techniques may not be the most appropriate. Read More

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November 2018
1 Read

Novel Tetrazole-containing Analogs of Itraconazole as Potent Anti-angiogenic Agents with Reduced CYP3A4 Inhibition.

J Med Chem 2018 Nov 27. Epub 2018 Nov 27.

Itraconazole has been found to possess potent anti-angiogenic activity, exhibiting promising antitumor activity in several human clinical studies. The wider use of itraconazole in the treatment of cancer, however, has been limited by its potent inhibition of the drug metabolizing enzyme CYP3A4. In an effort to eliminate the CYP3A4 inhibition while retaining its anti-angiogenic activity, we designed and synthesized a series of derivatives in which the 1, 2, 4-triazole ring is replaced with various azoles and non-azoles. Read More

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November 2018
1 Read
5.447 Impact Factor

Neighborhood bystander intervention in intimate partner abuse: The role of social cohesion.

J Community Psychol 2018 Nov 26. Epub 2018 Nov 26.

Utah State University.

This study examines the relationships among individual beliefs about intimate partner abuse (IPA), attitudes about IPA reporting, social cohesion, and the intention of intervening in neighborhood IPA. Data for this study come from a larger cross-sectional, community-based study in which participants (N = 1,626) were surveyed face to face using stratified random sampling in targeted communities in a Mountain West state (i.e. Read More

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November 2018
4 Reads

Exploring the Therapeutic Landscape of Sphingomyelinases.

Handb Exp Pharmacol 2018 Nov 27. Epub 2018 Nov 27.

Biochemistry and Cell Biology, Stony Brook University, Stony Brook, NY, USA.

Sphingosine, ceramide, sphingosine-1-phosphate, and other related sphingolipids have emerged as important bioactive molecules involved in a variety of key cellular processes such as cell growth, differentiation, apoptosis, exosome release, and inter- and intracellular cell communication, making the pathways of sphingolipid metabolism a key domain in maintaining cell homeostasis (Hannun and Obeid, Trends Biochem Sci 20:73-77, 1995; Hannun and Obeid, Nat Rev Mol Cell Biol 9:139-150, 2008; Kosaka et al., J Biol Chem 288:10849-10859, 2013). Various studies have determined that these pathways play a central role in regulating intracellular production of ceramide and the other bioactive sphingolipids and hence are an important component of signaling in various diseases such as cancer, diabetes, and neurodegenerative and cardiovascular diseases (Chaube et al. Read More

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November 2018
1 Read

Pediatric Considerations Before, During, and After Radiological or Nuclear Emergencies.

Pediatrics 2018 Dec;142(6)

Infants, children, and adolescents can be exposed unexpectedly to ionizing radiation from nuclear power plant events, improvised nuclear or radiologic dispersal device explosions, or inappropriate disposal of radiotherapy equipment. Children are likely to experience higher external and internal radiation exposure levels than adults because of their smaller body and organ size and other physiologic characteristics as well as their tendency to pick up contaminated items and consume contaminated milk or foodstuffs. This technical report accompanies the revision of the 2003 American Academy of Pediatrics policy statement on pediatric radiation emergencies by summarizing newer scientific data from studies of the Chernobyl and the Fukushima Daiichi nuclear power plant events, use of improvised radiologic dispersal devices, exposures from inappropriate disposal of radiotherapy equipment, and potential health effects from residential proximity to nuclear plants. Read More

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December 2018
2 Reads

Influence of response instructions and response format on applicant perceptions of a situational judgement test for medical school selection.

BMC Med Educ 2018 Nov 26;18(1):282. Epub 2018 Nov 26.

Institute of Medical Education Research Rotterdam, Erasmus MC, IMERR, Room AE-227, PO Box 2040, 3000CA, Rotterdam, the Netherlands.

Background: This study examined the influence of two Situational Judgement Test (SJT) design features (response instructions and response format) on applicant perceptions. Additionally, we investigated demographic subgroup differences in applicant perceptions of an SJT.

Methods: Medical school applicants (N = 372) responded to an online survey on applicant perceptions, including a description and two example items of an SJT. Read More

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November 2018
1 Read

Development of a novel nomogram for predicting ongoing pregnancy after fertilization and embryo transfer.

Obstet Gynecol Sci 2018 Nov 8;61(6):669-674. Epub 2018 Oct 8.

Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea.

Objective: This study aimed to develop a nomogram that predicts ongoing pregnancy after fertilization and embryo transfer (IVF-ET) using patient age and serum hormonal markers.

Methods: A total of 284 IVF-ET cycles were retrospectively analyzed. At 14 days post-oocyte pick-up (OPU), the serum human chorionic gonadotropin (HCG) and progesterone levels were measured. Read More

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November 2018
1 Read

Simultaneously targeted and untargeted multicomponent characterization of Erzhi Pill by offline two-dimensional liquid chromatography/quadrupole-Orbitrap mass spectrometry.

J Chromatogr A 2018 Nov 16. Epub 2018 Nov 16.

Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, 312 Anshanxi Road, Tianjin, 300193, China; Shanghai Research Center for Modernization of Traditional Chinese Medicine, National Engineering Laboratory for TCM Standardization Technology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Shanghai, 201203, China. Electronic address:

Large-scale targeted and untargeted metabolites characterization can be achieved by feat of different liquid chromatography/mass spectrometry (LC-MS) platforms by multiple MS experiments or using data-independent acquisition followed by precursor-product ions matching based on certain algorithms. The resulting insufficiency in efficiency and availability greatly restricts the applicability of these strategies in large-scale profiling and identification of various metabolites. A strategy simultaneously enabling both the targeted and untargeted metabolites characterization is established on a Q Exactive hybrid quadrupole-Orbitrap mass spectrometer, by integrating precursor ions list-triggered data-dependent MS acquisition (PIL/dd-MS) of the targeted components and using the "If idle-pick others" (IIPO) function to induce untargeted metabolites fragmentation. Read More

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November 2018
3 Reads

Pharmacokinetics and efficacy of PT302, a sustained-release Exenatide formulation, in a murine model of mild traumatic brain injury.

Neurobiol Dis 2018 Nov 21. Epub 2018 Nov 21.

Drug Design and Development Section, Translational Gerontology Branch, Intramural Research Program, National Institutes of Health, National Institute on Aging, Baltimore, MD, USA; Peptron Inc., Yuseong-gu, Daejeon, Republic of Korea.

Traumatic brain injury (TBI) is a neurodegenerative disorder for which no effective pharmacological treatment is available. Glucagon-like peptide 1 (GLP-1) analogues such as Exenatide have previously demonstrated neurotrophic and neuroprotective effects in cellular and animal models of TBI. However, chronic or repeated administration was needed for efficacy. Read More

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November 2018
9 Reads

A hypothesis about the origin of carotenoid lipid droplets in the green algae Dunaliella and Haematococcus.

Planta 2018 Nov 23. Epub 2018 Nov 23.

Department of Chemistry and Biochemistry, University of California, Los Angeles, CA, 90095-1569, USA.

Main Conclusion: Hypercarotenogenesis in green algae evolved by mutation of PSY that increased its transcription at high light, disintegration of the eyespot in Dunaliella and acquisition of the capacity to export carotenoids from chloroplasts in Haematococcus. Carotenoids (Car) are lipid-soluble pigments synthesized in plants, algae, bacteria and fungi. Car have strong antioxidative properties and as such are utilized to reduce the danger of different diseases in humans. Read More

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November 2018
3 Reads

A robotic microsurgical forceps for transoral laser microsurgery.

Int J Comput Assist Radiol Surg 2018 Nov 21. Epub 2018 Nov 21.

Department of Advanced Robotics, Istituto Italiano di Tecnologia, Via Morego 30, 16163, Genoa, Italy.

Purpose: In transoral laser microsurgery (TLM), the close curved cylindrical structure of the laryngeal region offers functional challenges to surgeons who operate on its malignancies with rigid, single degree-of-freedom (DOF) forceps. These challenges include surgeon hand tremors, poor reachability, poor tissue surface perception, and reduced ergonomy in design. The integrated robotic microsurgical forceps presented here is capable of addressing the above challenges through tele-operated tissue manipulation in TLM. Read More

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November 2018
5 Reads

Decrease in preovulatory serum estradiol is a valuable marker for predicting premature ovulation in natural/unstimulated in vitro fertilization cycle.

J Ovarian Res 2018 Nov 21;11(1):96. Epub 2018 Nov 21.

Department of Assisted Reproduction, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, 639 Zhizaoju Rd, Shanghai, 200011, China.

Background: Premature ovulation occurs at a high rate in natural-cycle in vitro fertilization (IVF), and cycle cancellation further hampers the overall efficiency of the procedure. While lower levels of estradiol (E2) are observed in preovulatory follicles, it is unclear whether declines in E2 can be used as an effective marker of premature ovulation.

Methods: This retrospective analysis includes 801 natural/unstimulated IVF/ICSI cycles undergoing scheduled ovum pick-up (OPU) and 153 natural/unstimulated IVF/ICSI cycles undergoing emergency OPU at a university IVF center from May 2014 to February 2017. Read More

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November 2018
2 Reads

Association of Uncoupling Protein 1 (UCP1) gene polymorphism with obesity: a case-control study.

BMC Med Genet 2018 Nov 20;19(1):203. Epub 2018 Nov 20.

Department of Biochemistry, Imam Abdulrahman Bin Faisal University, Dammam, 31441, Saudi Arabia.

Background: Obesity is one of the main causes of morbidity and mortality worldwide. More than 120 genes have been shown to be associated with obesity related phenotypes. The aim of this study was to determine the effect of selected genetic polymorphisms in Uncoupling protein 1 (UCP1) and Niemann-Pick C1 (NPC1) genes in an obese population in Saudi Arabia. Read More

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November 2018
9 Reads

Emotional processing in functional neurological disorder: a review, biopsychosocial model and research agenda.

J Neurol Neurosurg Psychiatry 2018 Nov 19. Epub 2018 Nov 19.

Section of Cognitive Neuropsychiatry, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.

Functional neurological disorder (FND) is a common and highly disabling disorder, but its aetiology remains enigmatic. Conceptually, there has been reduced emphasis on the role of psychosocial stressors in recent years, with a corresponding increase in neurobiological explanations. However, a wealth of evidence supports the role of psychosocial adversities (eg, stressful life events, interpersonal difficulties) as important risk factors for FND. Read More

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November 2018
3 Reads

Understanding Moment-to-Moment Processing of Visual Narratives.

Cogn Sci 2018 Nov 16;42(8):2999-3033. Epub 2018 Nov 16.

Department of Psychological Sciences, Kansas State University.

What role do moment-to-moment comprehension processes play in visual attentional selection in picture stories? The current work uniquely tested the role of bridging inference generation processes on eye movements while participants viewed picture stories. Specific components of the Scene Perception and Event Comprehension Theory (SPECT) were tested. Bridging inference generation was induced by manipulating the presence of highly inferable actions embedded in picture stories. Read More

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November 2018
4 Reads

Delayed Application of Binding Condition C During Cataphoric Pronoun Resolution.

J Psycholinguist Res 2018 Nov 15. Epub 2018 Nov 15.

Potsdam Research Institute for Multilingualism, University of Potsdam, Karl Liebknecht- Strasse 24-25, 14476, Potsdam, Germany.

Previous research has shown that during cataphoric pronoun resolution, the predictive search for an antecedent is restricted by a structure-sensitive constraint known as 'Condition C', such that an antecedent is only considered when the constraint does not apply. Evidence has mainly come from self-paced reading (SPR), a method which may not be able to pick up on short-lived effects over the timecourse of processing. This study investigates whether or not the active search mechanism is constrained by Condition C at all points in time during cataphoric processing. Read More

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November 2018
1 Read

Gadolinium Chloride Rescues Niemann⁻Pick Type C Liver Damage.

Int J Mol Sci 2018 Nov 14;19(11). Epub 2018 Nov 14.

Departamento de Gastroenterología, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago 8331150, Chile.

Niemann⁻Pick type C (NPC) disease is a rare neurovisceral cholesterol storage disorder that arises from loss of function mutations in the or genes. Soon after birth, some patients present with an aggressive hepatosplenomegaly and cholestatic signs. Histopathologically, the liver presents with large numbers of foam cells; however, their role in disease pathogenesis has not been explored in depth. Read More

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November 2018
2 Reads

Limited-view CT Reconstruction Based on Autoencoder-like Generative Adversarial Networks with Joint Loss.

Conf Proc IEEE Eng Med Biol Soc 2018 Jul;2018:5570-5574

Limiting the scan views of X-ray computed tomography (CT) can make radiation dose reduced efficiently and consequently weaken the damage of ionizing radiation. However, it will degrade the reconstructed CT images. In this paper, we proposed to predict the missing projections and improve the reconstructed CT images by constructing an autoencoder-like generative adversarial network (GAN) with joint loss function. Read More

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July 2018
3 Reads

Optimization of Tetrapolar Impedance Electrodes in Microfluidic Devices for Point of Care Diagnostics using Finite Element Modeling.

Conf Proc IEEE Eng Med Biol Soc 2018 Jul;2018:5321-5324

Electrophoresis is widely applied in the field of biochemistry and molecular biology. Tetrapolar electrical impedance sensing (TEIS) has been shown capable of replacing the conventional detection technology in order to develop a point of care electrophoretic analyzer. Besides the advantages of reduced influence of electrode polarization, TEIS is affected by sensitivity distribution depending on the electrode design. Read More

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July 2018
1 Read

Performance of graphene ECG electrodes under varying conditions.

Conf Proc IEEE Eng Med Biol Soc 2018 Jul;2018:3813-3816

Smart garments for invisible health sensing have been available for a number of years, with heart sensing typically performed using silver loaded conductive threads integrated into the fabric to pick up the electrocardiogram. Recent work has investigated printed graphene textiles as an alternative to this, which are potentially more environmentally friendly, cost-effective, and can be performed after garment manufacturing. This paper presents an exploration of second order factors on the performance of graphene textile electrodes for electrocardiogram measurements. Read More

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July 2018
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Comparison of Different Strategies to Assess Cardiac Baroreflex Sensitivity Based on Transfer Function Technique in Patients Undergoing General Anesthesia.

Conf Proc IEEE Eng Med Biol Soc 2018 Jul;2018:2780-2783

Baroreflex sensitivity (BRS) can be noninvasively assessed from heart period (HP) and arterial pressure (AP) variability series via the estimation of the gain of the transfer function (TF) in the low frequency (LF, 0.04-0.15 Hz) band. Read More

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July 2018
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Evaluation of Compensatory Movement by Shoulder Joint Torque during Gain Adjustment of a Powered Prosthetic Wrist Joint.

Conf Proc IEEE Eng Med Biol Soc 2018 Jul;2018:1891-1894

Powered prostheses with low degree of freedom (DoF) have been developed for people with disabilities to assist daily tasks. These prostheses neglect the user's compensatory movements caused by the low degree of freedom. We assume that the movements can be reduced by well-designed controller of the devices. Read More

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July 2018
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Early fetal echocardiography.

Birth Defects Res 2018 Nov 14. Epub 2018 Nov 14.

Fetal & Neonatal Cardiology Program, Division of Cardiology, Department of Pediatrics, Stollery Children's Hospital, Edmonton, Alberta, Canada.

Objectives: To explore the technical aspects and clinical utility of early fetal echocardiography and screening of the fetal heart in early pregnancy. Also, to document differences in cardiac structure and function which can be demonstrated in the late first/early second trimesters.

Methods: In addition to summarizing our own experiences of late first/early second trimester fetal echocardiography, we reviewed the literature to explore clinical indications for, technical aspects, safety, accuracy, strengths and weaknesses of early fetal echocardiography. Read More

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November 2018
6 Reads