7,177 results match your criteria Phytochemistry[Journal]


Chemometric analysis of Amaranthus retroflexus in relation to livestock toxicity in southern Australia.

Phytochemistry 2019 Feb 15;161:1-10. Epub 2019 Feb 15.

Graham Centre for Agricultural Innovation (Charles Sturt University and NSW Department of Primary Industries), Wagga Wagga, NSW, 2650, Australia; Charles Sturt University, School of Agricultural and Wine Sciences, Wagga Wagga, NSW, 2678, Australia.

Amaranthus retroflexus L., an introduced invasive weed in southern Australia, has been associated with acute renal failure and/or mortality in a number of livestock species. While its leaves, flowers and stems are generally reported to contain high levels of nitrogen, few studies have fully characterised the chemical composition of A. Read More

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http://dx.doi.org/10.1016/j.phytochem.2019.01.016DOI Listing
February 2019

Steroidal glycosides from Ornithogalum dubium Houtt.

Phytochemistry 2019 Feb 8;160:78-84. Epub 2019 Feb 8.

Laboratoire de Pharmacognosie, PEPITE EA 4267, UFR des Sciences de Santé, Université de Bourgogne Franche-Comté, 21079, Dijon Cedex, France. Electronic address:

The phytochemical study of Ornithogalum dubium Houtt. (Asparagaceae) led to the isolation of five undescribed steroidal glycosides together with two known ones. Their structures were established by using NMR analysis and mass spectrometry as (25R)-3β-hydroxyspirost-5-en-1β-yl O-α-L-arabinopyranosyl-(1 → 2)-α-L-rhamnopyranoside, (25S)-3β-hydroxyspirost-5-en-1β-yl O-β-D-glucopyranosyl-(1 → 6)-β-D-glucopyranoside, (22S)-16β-[(α-L-rhamnopyranosyl)oxy]-22-hydroxycholest-5-en-3β-yl O-β-D-glucopyranosyl-(1 → 4)-β-D-glucopyranoside, (22S,23S)-1β,3β,11α,16β,23-pentahydroxy-5α-cholest-24-en-22β-yl β-D-glucopyranoside, (22S,23S)-3β-[(β-D-glucopyranosyl)oxy]-22,23-dihydroxy-5α-cholest-24-en-16β-yl O-α-L-rhamnopyranosyl)-(1 → 4)-β-D-glucopyranoside. Read More

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http://dx.doi.org/10.1016/j.phytochem.2019.01.013DOI Listing
February 2019

Diterpenoid alkaloids from the whole plant of Aconitum tanguticum (Maxim.) Stapf.

Phytochemistry 2019 Feb 5;160:71-77. Epub 2019 Feb 5.

Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, China.

Five undescribed diterpenoid alkaloids tanguticulines A-E and two undescribed amide compounds 5-methoxy-N-Salicylanthranilic acid methyl ester and 3, 5-dimethoxy-4- hydroxycinnamamide-4-O-β-D-glucopyranoside, were isolated from the whole plant of Aconitum tanguticum (Maxim.) Stapf. Their structures were assigned by detailed analysis of MS and NMR spectroscopic data. Read More

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http://dx.doi.org/10.1016/j.phytochem.2018.11.008DOI Listing
February 2019

Cytochrome P450 enzymes: A driving force of plant diterpene diversity.

Phytochemistry 2019 Feb 5. Epub 2019 Feb 5.

Department of Cell and Metabolic Biology, Leibniz Institute of Plant Biochemistry, Weinberg 3, 06120 Halle, Germany. Electronic address:

In plant terpene biosynthesis, oxidation of the hydrocarbon backbone produced by terpene synthases is typically carried out by cytochrome P450 oxygenases (CYPs). The modifications introduced by CYPs include hydroxylations, sequential oxidations at one position and ring rearrangements and closures. These reactions significantly expand the structural diversity of terpenoids, but also provide anchoring points for further decorations by various transferases. Read More

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http://dx.doi.org/10.1016/j.phytochem.2018.12.003DOI Listing
February 2019

Volatile monoterpene 'fingerprints' of resinous Protium tree species in the Amazon rainforest.

Phytochemistry 2019 Feb 1;160:61-70. Epub 2019 Feb 1.

Climate and Ecosystem Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA; Department of Geography, University of California Berkeley, Berkeley, CA, USA. Electronic address:

Volatile terpenoid resins represent a diverse group of plant defense chemicals involved in defense against herbivory, abiotic stress, and communication. However, their composition in tropical forests remains poorly characterized. As a part of tree identification, the 'smell' of damaged trunks is widely used, but is highly subjective. Read More

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http://dx.doi.org/10.1016/j.phytochem.2019.01.014DOI Listing
February 2019

Chemical components from Metapanax delavayi leaves and their anti-BHP activities in vitro.

Phytochemistry 2019 Jan 31;160:56-60. Epub 2019 Jan 31.

School of Pharmacy, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, PR China. Electronic address:

Two previously undescribed oleanane-type triterpene saponins named liangwanosides III-IV, and one undescribed eudesmane glycoside named liangwanoside A were obtained from the leaves of Metapanax delavayi, a Chinese folk medicine especially for tea used in Yunnan, together with four known compounds. The structures of the undescribed compounds were determined by detailed spectroscopic (1D/2D NMR), HR-ESI-MS data analysis and chemical evidence. The activity against human benign prostate hyperplasia was evaluated with BPH-1 cell line. Read More

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http://dx.doi.org/10.1016/j.phytochem.2019.01.002DOI Listing
January 2019
3 Reads

Cytotoxic 9,19-cycloartane type triterpenoid glycosides from the roots of Actaea dahurica.

Phytochemistry 2019 Jan 29;160:48-55. Epub 2019 Jan 29.

State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China. Electronic address:

Ten undescribed 9,19-cycloartane type triterpenoid glycosides (cimdahxynoside A-J) and five known analogues were obtained from the phytochemical research on the roots of Actaea dahurica (syn. Cimicifuga dahurica). All compounds were characterised by spectroscopic experiments, chemical method and X-ray Single-crystal diffraction analysis. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00319422183043
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http://dx.doi.org/10.1016/j.phytochem.2019.01.004DOI Listing
January 2019
3 Reads

Chemical partitioning and DNA fingerprinting of some pistachio (Pistacia vera L.) varieties of different geographical origin.

Phytochemistry 2019 Jan 25;160:40-47. Epub 2019 Jan 25.

Plant Physiology Unit, Dept. Life Sciences and Systems Biology. University of Turin, Via Quarello 15/a, 10135, Turin, Italy. Electronic address:

The genus Pistacia (Anacardiaceae family) is represented by several species, of which only P. vera L. produces edible seeds (pistachio). Read More

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http://dx.doi.org/10.1016/j.phytochem.2019.01.010DOI Listing
January 2019

Occurrence and distribution of unsubstituted B-ring flavanones in Eucalyptus foliage.

Phytochemistry 2019 Jan 22;160:31-39. Epub 2019 Jan 22.

Research School of Biology, The Australian National University, Canberra, ACT 2601, Australia.

A group of plant specialised metabolites (PSMs) collectively known as unsubstituted B-ring flavanones (UBFs) have previously been found in the foliage of some species from the genus Eucalyptus L'Hér. (Myrtaceae), specifically from the subgenus Eucalyptus (monocalypts). Captive feeding studies using artificial diets suggest that these compounds may potentially influence the feeding preferences of marsupial folivores, such as koalas. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00319422183067
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http://dx.doi.org/10.1016/j.phytochem.2019.01.005DOI Listing
January 2019
3 Reads
2.547 Impact Factor

LC-MS guided isolation and dereplication of Lycopodium alkaloids from Lycopodium cernuum var. sikkimense of different geographical origins.

Phytochemistry 2019 Jan 22;160:25-30. Epub 2019 Jan 22.

Department of Natural Products Chemistry, School of Pharmacy, Fudan University, Shanghai, 201203, PR China; Zhejiang Provincial Key Laboratory of Plant Evolutionary Ecology and Conservation, Taizhou University, Taizhou, 318000, Zhejiang, PR China. Electronic address:

Lycopodium alkaloids (LAs) are the characteristic metabolites of club mosses. Chemical differences often exist in different specimens of a single plant species collected from different geographic origins. In this study, a preliminary LC-MS detection and dereplication analyses of alkaloidal constituents of Lycopodium cernuum var. Read More

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http://dx.doi.org/10.1016/j.phytochem.2019.01.006DOI Listing
January 2019
1 Read

The influence of the H5⋯OC4 intramolecular hydrogen-bond (IHB) on the antioxidative activity of flavonoid.

Phytochemistry 2019 Jan 19;160:19-24. Epub 2019 Jan 19.

College of Bee Science, Fujian Agriculture and Forestry University, Fuzhou 350002, PR China. Electronic address:

Flavonoids widely found in natural foods are characterized by acting as antioxidants compounds. There are close relationship between the antiradical activities and structural properties of flavonoids. In this work, density functional theory (DFT) methods were applied to investigate the influence of the H5⋯OC4 intramolecular hydrogen-bond (IHB) on the antiradical activity of flavonoid based on three prevalently accepted radical scavenging mechanisms: hydrogen atom transfer (HAT), single electron transfer-proton transfer (SET-PT) and sequential proton-loss electron-transfer (SPLET). Read More

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http://dx.doi.org/10.1016/j.phytochem.2019.01.011DOI Listing
January 2019
1 Read

Characterization of enantiomeric lignanamides from Solanum nigrum L. and their neuroprotective effects against MPP-induced SH-SY5Y cells injury.

Phytochemistry 2019 Jan 17. Epub 2019 Jan 17.

School of Traditional Chinese Materia Medica, Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China. Electronic address:

Five pairs of enantiomeric lignanamides including nine undescribed compounds along with a known one were obtained from Solanum nigrum L. (Solanaceae). Their structures with absolute configurations were elucidated based on comprehensive spectroscopic analyses and quantum chemical calculations of electronic circular dichroism (ECD) curves. Read More

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http://dx.doi.org/10.1016/j.phytochem.2019.01.001DOI Listing
January 2019
1 Read

Identification of fermented tea (Camellia sinensis) polyphenols and their inhibitory activities against amyloid-beta aggregation.

Phytochemistry 2019 Jan 17;160:11-18. Epub 2019 Jan 17.

College of Pharmacy and Integrated Research Institute of Pharmaceutical Sciences, The Catholic University of Korea, Bucheon, 14662, Republic of Korea. Electronic address:

Thirty-three phenolic compounds were identified from the extract of fermented tea (Camellia sinensis L.), including three undescribed flavonoids, namely quamoreokchaside I-II and kamoreokchaside I, along with thirty known compounds. All isolates were tested to evaluate their inhibitory effects against amyloid-beta (Aβ) aggregation through thioflavin-T (ThT) fluorescence-based assay and transmission electron microscopy (TEM). Read More

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http://dx.doi.org/10.1016/j.phytochem.2018.12.013DOI Listing
January 2019
2 Reads

Cycloartane triterpenoids from Actaea vaginata with anti-inflammatory effects in LPS-stimulated RAW264.7 macrophages.

Phytochemistry 2019 Jan 11;160:1-10. Epub 2019 Jan 11.

College of Pharmaceutical Sciences, Zhejiang University, 866 Yuhangtang Road, Hangzhou 310058, PR China; Hangzhou Institute of Innovative Medicine, Zhejiang University, 291 Fucheng Road, Hangzhou 310018, PR China. Electronic address:

Five undescribed cycloartane triterpenoids, including two cycloartane trinor-triterpenoids, were isolated from a 70% ethanol extract of the whole plant of Actaea vaginata (Ranunculaceae), together with thirteen known cycloartane triterpenoids. Their structures were determined by spectroscopic techniques and quantum chemical calculations for intramolecular noncovalent interactions with reduced density gradient method. All compounds were evaluated for their anti-inflammatory effects by a lipopolysaccharide (LPS)-stimulated nitric oxide (NO) production model in RAW264. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00319422183053
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http://dx.doi.org/10.1016/j.phytochem.2019.01.003DOI Listing
January 2019
4 Reads

A phytochemical investigation of Stemona parviflora roots reveals several compounds with nematocidal activity.

Phytochemistry 2019 Mar 8;159:208-215. Epub 2019 Jan 8.

Hainan Key Laboratory for Research and Development of Natural Products from Li Folk Medicine, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agriculture Sciences, Haikou 571101, China. Electronic address:

Twelve undescribed compounds including six phenanthrene derivatives (parviphenanthrines A-F), two stilbene derivatives (parvistilbines A-B), three esters (parviesters A-C), and one sesquiterpenoid (parvidiol A) were isolated from the roots of Stemona parviflora, together with twenty-two known ones. The structures of the undescribed compounds were elucidated based on the analyses of their spectroscopic data. The absolute configuration of parviphenanthrine A was determined by the quantum ECD calculations. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00319422183048
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http://dx.doi.org/10.1016/j.phytochem.2018.12.021DOI Listing
March 2019
7 Reads

Cholinesterase inhibitory isoquinoline alkaloids from Corydalis mucronifera.

Phytochemistry 2019 Mar 9;159:199-207. Epub 2019 Jan 9.

Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing, 100191, People's Republic of China. Electronic address:

Eight previously undescribed isoquinoline alkaloids, mucroniferanines H-M, together with 16 known isoquinoline alkaloids, were isolated from Corydalis mucronifera Maxim.. The structures of the previously undescribed compounds were elucidated by interpretation of 1D and 2D NMR spectroscopic and HRMS data, and their absolute configurations were established by computational electronic circular dichroism (ECD) calculations and X-ray diffraction data. Read More

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http://dx.doi.org/10.1016/j.phytochem.2018.11.019DOI Listing
March 2019
2 Reads
2.547 Impact Factor

The identification and functional characterization of three liverwort class I O-methyltransferases.

Phytochemistry 2019 Mar 9;159:190-198. Epub 2019 Jan 9.

Key Laboratory of Chemical Biology of Natural Products, Ministry of Education, School of Pharmaceutical Sciences, Shandong University, Jinan, 250012, China. Electronic address:

Previously it has been shown that the caffeoyl coenzyme A O-methyltransferase (CCoAOMT) type enzyme PaF6OMT, synthesized by the liverwort Plagiochasma appendiculatum Lehm. & Lindenb., (Aytoniaceae), interacts preferentially with 6-OH flavones. Read More

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http://dx.doi.org/10.1016/j.phytochem.2018.12.001DOI Listing
March 2019
2 Reads

Biosynthesis of methyleugenol and methylisoeugenol in Daucus carota leaves: Characterization of eugenol/isoeugenol synthase and O-Methyltransferase.

Phytochemistry 2019 Mar 9;159:179-189. Epub 2019 Jan 9.

Newe Yaar Research Center, Agricultural Research Organization, P. O. Box 1021, Ramat Yishay, 30095, Israel. Electronic address:

Carrot (Daucus carota subsp. sativus) is a widely cultivated root vegetable of high economic importance. The aroma of carrot roots and aboveground organs is mainly defined by terpenes. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00319422183024
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http://dx.doi.org/10.1016/j.phytochem.2018.12.020DOI Listing
March 2019
3 Reads
2.547 Impact Factor

Phytochemical profiles of the leaves of Stizolophus balsamita and Psephellus sibiricus and their chemotaxonomic implications.

Phytochemistry 2019 Mar 9;159:172-178. Epub 2019 Jan 9.

Department of Medicinal and Cosmetic Natural Products, Poznan University of Medical Sciences, Mazowiecka Str. 33, 60-623 Poznan, Poland. Electronic address:

Seven germacranolides - balsamin, izospiciformin, stizolin, 9α-hydroxyparthenolide, 8α-E-(4'-hydroxy)-senecioyloxy-9α-hydroxyparthenolide, stizolicin and 11βH,13-dihydrostizolicin, as well as one undescribed phenol glycoside 3-(3,4-dihydroxyphenyl) propyl senecioate 3-O-β-glucopyranoside were isolated from the leaves of Stizolophus balsamita growing in Iran. Three coumarins, scoparone, scopoletin, umbelliferone and two guaianolides, cynaropicrin and desacylcynaropicrin 8α-(Z)-(4'-hydroxy-2'-methyl)butenoate (= cebellin F) were isolated from the leaves of Psephellus sibiricus. Phytochemical profile of Stizolophus balsamita growing in Iran differs from that of Stizolophus balsamita growing in Kazakhstan. Read More

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http://dx.doi.org/10.1016/j.phytochem.2018.12.022DOI Listing
March 2019
1 Read

Purification and characterization of Bowman-Birk and Kunitz isoinhibitors from the seeds of Rhynchosia sublobata (Schumach.) Meikle, a wild relative of pigeonpea.

Phytochemistry 2019 Mar 9;159:159-171. Epub 2019 Jan 9.

Department of Biotechnology & Bioinformatics, School of Life Sciences, University of Hyderabad, Hyderabad, 500 046, Telangana, India. Electronic address:

Rhynchosia sublobata, a wild relative of pigeonpea, possesses defensive proteinase/protease inhibitors (PIs). Characterization of trypsin specific PIs (RsPI) separated from seeds by column chromatography using 2-D gel electrophoresis and Edman degradation method identified R. sublobata possessed both Bowman-Birk isoinhibitors (RsBBI) and Kunitz isoinhibitors (RsKI). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00319422183088
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http://dx.doi.org/10.1016/j.phytochem.2018.12.018DOI Listing
March 2019
3 Reads

In depth LC-ESIMS-guided phytochemical analysis of Ziziphus jujuba Mill. leaves.

Phytochemistry 2019 Mar 4;159:148-158. Epub 2019 Jan 4.

Dipartimento di Farmacia, Università degli Studi di Salerno, Via Giovanni Paolo II, 84084, Salerno, Italy. Electronic address:

Ziziphus jujuba Mill. leaves are receiving a great attention for their ability to improve sleep, exerting beneficial effects for both the heart and the central nervous system. With the aim to obtain a comprehensive analysis of the specialised metabolites occurring in the leaves of Z. Read More

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http://dx.doi.org/10.1016/j.phytochem.2018.12.014DOI Listing
March 2019
1 Read

Dynamic translocation of stilbene synthase VpSTS29 from a Chinese wild Vitis species upon UV irradiation.

Phytochemistry 2019 Mar 3;159:137-147. Epub 2019 Jan 3.

College of Horticulture, Northwest A & F University, Yangling, Shaanxi, 712100, People's Republic of China; Key Laboratory of Horticultural Plant Biology and Germplasm Innovation in Northwest China, Ministry of Agriculture, Yangling, Shaanxi, 712100, People's Republic of China; State Key Laboratory of Crop Stress Biology in Arid Areas, Northwest A&F University, Yangling, Shaanxi, 712100, People's Republic of China. Electronic address:

Stilbene phytoalexins derived from grapevine can be rapidly accumulated when exposed to an artificial UV-C treatment. However, the underlying mechanisms involved in this accumulation and translocation are unclear. Here, we describe an investigation of the influence of UV-C treatment on the dynamic subcellular distribution of a member of a stilbene synthase family VpSTS29 derived from Chinese wild Vitis pseudoreticulata W. Read More

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http://dx.doi.org/10.1016/j.phytochem.2018.12.019DOI Listing
March 2019
10 Reads

Metabolomics as a complement to phylogenetics for assessing intraspecific boundaries in the desiccation-tolerant medicinal shrub Myrothamnus flabellifolia (Myrothamnaceae).

Phytochemistry 2019 Mar 3;159:127-136. Epub 2019 Jan 3.

Department of Molecular and Cell Biology, University of Cape Town, Private Bag, 7701, Cape Town, South Africa. Electronic address:

The desiccation-tolerant shrub Myrothamnus flabellifolia has colonised a unique and harsh niche that provides little protection from the elements. It has a wide distribution range in southern Africa, occurring across an environmental gradient that is exceptionally arid in the southwest and highly mesic in the northeast. It is also harvested for use in medicinal preparations, both traditionally and commercially. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00319422183051
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http://dx.doi.org/10.1016/j.phytochem.2018.12.016DOI Listing
March 2019
3 Reads

Inter-organ transport of secologanin allows assembly of monoterpenoid indole alkaloids in a Catharanthus roseus mutant.

Phytochemistry 2019 Mar 3;159:119-126. Epub 2019 Jan 3.

Department of Biological Sciences, Brock University, 1812 Sir Isaac Brock Way, St. Catharines, L2S 3A1, Canada. Electronic address:

The medicinal value of the monoterpenoid indole alkaloids (MIAs) such as 3',4'-anhydrovinblastine, as well as their chemical complexity have stimulated extensive efforts to understand the biochemical and molecular pathways involved in their biosynthesis in plants such as Catharanthus roseus, Rawvolfia serpentina and others. Ethyl methane sulphonate (EMS) mutagenesis has been used successfully together with simple MIA thin layer chromatography screening to identify C. roseus mutants with altered MIA profiles. Read More

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http://dx.doi.org/10.1016/j.phytochem.2018.12.017DOI Listing
March 2019
1 Read

Water deficit and abscisic acid treatments increase the expression of a glucomannan mannosyltransferase gene (GMMT) in Aloe vera Burm. F.

Phytochemistry 2019 Mar 31;159:90-101. Epub 2018 Dec 31.

Centro de Biología Molecular Vegetal, Departamento de Biología, Facultad de Ciencias, Universidad de Chile, Chile. Electronic address:

The main polysaccharide of the gel present in the leaves of or Aloe vera Burm.F., (Aloe barbadensis Miller) a xerophytic crassulacean acid metabolism (CAM) plant, is an acetylated glucomannan named acemannan. Read More

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http://dx.doi.org/10.1016/j.phytochem.2018.12.009DOI Listing
March 2019
1 Read

Acylated pelargonidin glycosides from the red-purple flowers of Iberis umbellata L. and the red flowers of Erysimum × cheiri (L.) Crantz (Brassicaceae).

Authors:
Fumi Tatsuzawa

Phytochemistry 2019 Mar 31;159:108-118. Epub 2018 Dec 31.

Faculty of Agriculture, Iwate University, Morioka 020-8550, Japan. Electronic address:

Five previously undescribed acylated pelargonidin 3-sophoroside-5-glucosides (pigments 2-6) were isolated from the red-purple flowers of Iberis umbellata L. 'Candycane Rose' and 'Candycane Red', in addition to a known one (pigment 1). The structures of five undescribed acylated anthocyanins were determined by chemical and spectroscopic methods to be pelargonidin 3-O-[2-O-(2-O-("acyl-A")-β-glucopyranosyl)-6-O-("acyl-B")-β-glucopyranoside]-5-O-[6-O-(malonyl)-β-glucopyranoside], in which the "acyl-A" group was either trans-sinapic (2), trans-ferulic (3), trans-sinapic (4), trans-ferulic (5), or trans-ferulic acid (6), and "acyl-B" was either glucosyl-trans-p-coumaric acid (2), glucosyl-trans-p-coumaric acid (3), trans-feruloyl-glucosyl-trans-p-coumaric acid (4), trans-feruloyl-glucosyl-trans-p-coumaric acid (5), or glucosyl-trans-feruloyl-glucosyl-trans-p-coumaric acid (6). Read More

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http://dx.doi.org/10.1016/j.phytochem.2018.12.010DOI Listing
March 2019
1 Read

Stress-induced modification of indole alkaloids:Phytomodificines as a new category of specialized metabolites.

Phytochemistry 2019 Mar 31;159:102-107. Epub 2018 Dec 31.

Institute for Plant Biology, TU Braunschweig, Mendelssohnsstr. 4, 38106, Braunschweig, Germany. Electronic address:

This study focuses on the elucidation of the stress-induced reverse changes of major indole alkaloids in Vinca minor, primarily on the postulated conversion of vincamine and vincadifformine to yield 9-methoxyvincamine, minovincine, and minovincinine, respectively. By applying the P450 enzyme inhibitors, naproxen and resveratrol, it was shown that the oxidative reaction involved in the postulated conversion of vincamine and vincadifformine is catalyzed by cytochrome P450 enzymes. In combination with the identification of 9-hydroxyvincamine as a postulated intermediate, this result confirms that the observed stress-induced reverse changes in the alkaloid pattern are caused by modifications of the alkaloids which regularly accumulate in the healthy Vinca minor plants. Read More

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http://dx.doi.org/10.1016/j.phytochem.2018.12.015DOI Listing
March 2019
3 Reads

Temporal resistance of potato tubers: Antibacterial assays and metabolite profiling of wound-healing tissue extracts from contrasting cultivars.

Phytochemistry 2019 Mar 28;159:75-89. Epub 2018 Dec 28.

Department of Chemistry and Biochemistry, The City College of New York, City University of New York and CUNY Institute for Macromolecular Assemblies, New York, NY 10031, USA; Ph.D. Program in Chemistry, CUNY Graduate Center, New York, NY 10016, USA; Ph.D. Program in Biochemistry, CUNY Graduate Center, New York, NY 10016, USA. Electronic address:

Solanum tuberosum, commonly known as the potato, is a worldwide food staple. During harvest, storage, and distribution the crop is at risk of mechanical damage. Wounding of the tuber skin can also become a point of entry for bacterial and fungal pathogens, resulting in substantial agricultural losses. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00319422183025
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http://dx.doi.org/10.1016/j.phytochem.2018.12.007DOI Listing
March 2019
6 Reads
2.547 Impact Factor

Polycyclic polyprenylated acylphloroglucinol and phenolic metabolites from the aerial parts of Hypericum elatoides and their neuroprotective and anti-neuroinflammatory activities.

Phytochemistry 2019 Mar 26;159:65-74. Epub 2018 Dec 26.

Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling 712100, People's Republic of China. Electronic address:

A phytochemical study on the aerial parts of Hypericum elatoides led to the isolation of a previously undescribed polycyclic polyprenylated acylphloroglucinol derivative, hyperelatone A, seven previously undescribed phenolic metabolites, hyperelatones B-H, along with ten known analogues. The structures of hyperelatones A-H were elucidated by 1D and 2D NMR spectroscopy, HRESIMS experiment, single-crystal X-ray diffraction and comparison of experimental and calculated ECD spectra, as well as chemical derivatization. All compounds were evaluated for their neuroprotective activity against hydrogen peroxide (HO)-induced cell injury in rat pheochromocytoma PC-12 cells and inhibitory effects on lipopolysaccharide (LPS)-induced nitric oxide (NO) production in BV-2 microglial cells. Read More

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http://dx.doi.org/10.1016/j.phytochem.2018.12.011DOI Listing
March 2019
2 Reads

Hyperbeanols F-Q, diverse monoterpenoid polyprenylated acylphloroglucinols from the flowers of Hypericum beanii.

Phytochemistry 2019 Mar 20;159:56-64. Epub 2018 Dec 20.

State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Bioactive Natural Product Research, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, 210009, PR China. Electronic address:

Hyperbeanols F-Q, which are twelve undescribed monoterpenoid polyprenylated acylphloroglucinols, and four known analogues were isolated from the dried flowers of Hypericum beanii. Their structures were elucidated by detailed HRESIMS and 1D and 2D NMR data analyses. The absolute configurations of hyperbeanols FH were established by the circular dichroism (CD) exciton chirality method. Read More

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http://dx.doi.org/10.1016/j.phytochem.2018.12.005DOI Listing
March 2019
1 Read

Peptide from thaumatin plant protein exhibits selective anticandidal activity by inducing apoptosis via membrane receptor.

Phytochemistry 2019 Mar 19;159:46-55. Epub 2018 Dec 19.

Universidade Federal do Ceará, Departamento de Bioquímica e Biologia Molecular, CEP 60.440-970, Fortaleza, Ceará, Brazil. Electronic address:

Osmotin- and thaumatin-like proteins (OLPs and TLPs) have been associated with plant defense responses to different biotic stresses. In the present work, several in silico sequences from OLPs and TLPs were investigated by means of bioinformatics tools aiming to prospect for antimicrobial peptides. The peptide sequences chosen were further synthesized and characterized, and their activities and action mechanisms were assayed against some phytopathogenic fungi, bacteria and yeasts of clinical importance. Read More

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http://dx.doi.org/10.1016/j.phytochem.2018.12.006DOI Listing
March 2019
1 Read

Enantiomeric β-carboline dimers from Picrasma quassioides and their anti-hepatoma potential.

Phytochemistry 2019 Mar 19;159:39-45. Epub 2018 Dec 19.

School of Traditional Chinese Materia Medica, Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, Liaoning Province, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China. Electronic address:

Four pairs of enantiomeric β-carboline alkaloids, (+/-)-kumudine A-D, along with their biosynthesis-related compound kumudine E, were obtained from the stems of Picrasma quassioides. Their structures, including the absolute configurations, were determined via extensive spectroscopic data combined with electronic circular dichroism (ECD) spectroscopic analyses and quantum mechanical ECD calculations. (+/-)-Kumudine A possessed a scaffold of β-carboline-phenylpropanoid adduct, which were the first examples of this type of β-carboline alkaloid from nature. Read More

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http://dx.doi.org/10.1016/j.phytochem.2018.12.002DOI Listing
March 2019
2 Reads

Iridoid glucosides in the genus Sutera (Scrophulariaceae) as chemotaxonomic markers in tribe Limoselleae.

Phytochemistry 2019 Feb 18;158:149-155. Epub 2018 Dec 18.

Department of Chemistry, The Technical University of Denmark, Build. 207, DK-2800 Lyngby, Denmark. Electronic address:

From two species of Sutera (S. foetida and S. cordata) (Scrophulariaceae tribe Limoselleae) were isolated three known secoiridoid glucosides (12-14) as well as four iridoid congeners (8-11), all biosynthetically derived from iridodial glucoside (and/or deoxyloganic acid). Read More

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http://dx.doi.org/10.1016/j.phytochem.2018.10.021DOI Listing
February 2019
2 Reads

Thiodiketopiperazines with two spirocyclic centers extracted from Botryosphaeria mamane, an endophytic fungus isolated from Bixa orellana L.

Phytochemistry 2019 Feb 18;158:142-148. Epub 2018 Dec 18.

UMR 152 Pharma Dev, Université de Toulouse, IRD, UPS, France. Electronic address:

Three thiodiketopiperazines, botryosulfuranols A-C (1-3) were isolated from the endophytic fungus Botryosphaeria mamane. The three compounds present sulfur atoms on α- and β-positions of phenylalanine derived residues and unprecedented two spirocyclic centers at C-4 and C-2'. Their planar structures were determined by spectroscopic analysis and absolute configurations were achieved by X-ray diffraction analysis and ECD and NMR chemical shifts calculations. Read More

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http://dx.doi.org/10.1016/j.phytochem.2018.11.007DOI Listing
February 2019
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Organ-specific distribution and non-enzymatic conversions indicate a metabolic network of phenylphenalenones in Xiphidium caeruleum.

Phytochemistry 2019 Mar 17;159:30-38. Epub 2018 Dec 17.

Max-Planck Institut für Chemische Ökologie, Beutenberg Campus, Hans-Knöll-Strasse 8, 07745, Jena, Germany. Electronic address:

We investigated the organ-specific phytochemistry of the inflorescences, leaves at different stages of senescence, and roots of Xiphidium caeruleum (Haemodoraceae) and elucidated the structure of six undescribed compounds. Among these, a phenylcarbamoylnaphthoquinone (PCNQ), representing the first member of a class of undescribed phenylphenalenone-derived nitrogenous compounds, was identified and its spontaneous formation elaborated. Starting from phenylbenzoisochromenone glucosides, the reaction cascade proceeds through oxidative decarboxylation and several oxidation steps to an anhydride, which is further converted to a carboxy-phenylnaphthoquinone. Read More

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http://dx.doi.org/10.1016/j.phytochem.2018.12.004DOI Listing
March 2019
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UPLC and ESI-MS analysis of metabolites of Rauvolfia tetraphylla L. and their spatial localization using desorption electrospray ionization (DESI) mass spectrometric imaging.

Phytochemistry 2019 Mar 17;159:20-29. Epub 2018 Dec 17.

DST Unit of Nanoscience and Thematic Unit of Excellence, Department of Chemistry, Indian Institute of Technology Madras, Chennai, 600036, India. Electronic address:

Rauvolfia tetraphylla L. (family Apocynaceae), often referred to as the wild snakeroot plant, is an important medicinal plant and produces a number of indole alkaloids in its seeds and roots. The plant is often used as a substitute for Ravuolfia serpentine (L. Read More

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http://dx.doi.org/10.1016/j.phytochem.2018.11.009DOI Listing
March 2019
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Mass spectrometry imaging of low molecular weight metabolites in strawberry fruit (Fragaria x ananassa Duch.) cv. Primoris with Ag nanoparticle enhanced target.

Phytochemistry 2019 Mar 11;159:11-19. Epub 2018 Dec 11.

Rzeszów University of Technology, Faculty of Chemistry, 6 Powstańców Warszawy Ave., 35-959, Rzeszów, Poland.

Strawberry (Fragaria x ananassa Duch., Rosaceae) is the subject of many research studies due to its numerous features such as unique taste, aroma and health qualities. The distribution of low molecular weight metabolites belonging to aldehydes, ketones, alcohols, esters, organic acids, phenolics, amino acids and sugars classes within strawberry fruit cross-section was studied using mass spectrometry imaging (MSI) method with Ag nanoparticle enhanced target (AgNPET). Read More

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http://dx.doi.org/10.1016/j.phytochem.2018.11.014DOI Listing
March 2019
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Volatile, stored and phloem exudate-located compounds represent different appearance levels affecting aphid niche choice.

Phytochemistry 2019 Mar 8;159:1-10. Epub 2018 Dec 8.

Department of Chemical Ecology, Bielefeld University, Universitätsstr. 25, 33615, Bielefeld, Germany. Electronic address:

Intraspecific and intra-individual differences in emitted volatile compounds and in surface and phloem sap-related metabolites do not only affect host plant choice of monophagous aphids but may also guide them to the plant part that provides their ideal niche by maximising their fitness. However, little is known about the variation at these different plant appearance levels. We investigated the preferences of the monophagous aphid species Macrosiphoniella tancetaria and Uroleucon tanaceti for different plant parts (inflorescence stems, young and old leaves) of Tanacetum vulgare plants from two chemotypes, testing their reactions towards volatile, surface and phloem sap-related cues. Read More

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http://dx.doi.org/10.1016/j.phytochem.2018.11.018DOI Listing
March 2019
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Cycloartane-type triterpenoid derivatives and a flavonoid glycoside from the burs of Castanea crenata.

Phytochemistry 2019 Feb 6;158:135-141. Epub 2018 Dec 6.

College of Pharmacy, Yonsei Institute of Pharmaceutical Sciences, Yonsei University, Incheon, 21983, South Korea. Electronic address:

Five undescribed cycloartane-type triterpenoids, which were isolated for the first time from the genus, and a flavonoid glycoside together with 11 known compounds were isolated from the burs of Castanea crenata. The structures were elucidated based on the spectroscopic analysis of 1D and 2D NMR and MS data. All isolated compounds were evaluated for antiviral activities against HRV1B-, CVB3-, and PR8-infected cells. Read More

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http://dx.doi.org/10.1016/j.phytochem.2018.11.001DOI Listing
February 2019
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2.547 Impact Factor

Undescribed C-geranylflavonoids isolated from the fruit peel of Paulownia catalpifolia T. Gong ex D.Y. Hong with their protection on human umbilical vein endothelial cells injury induced by hydrogen peroxide.

Phytochemistry 2019 Feb 5;158:126-134. Epub 2018 Dec 5.

Department of Pharmacology, School of Medicine, Shandong University, Jinan 250012, China.

Six undescribed C-geranylated flavonoids, including five C-geranylflavanones named as paucatalinones F - J, one C-geranylflavonol named as paucatalinone K, along with seven known geranylated flavanones, were isolated from the fruit peel of Paulownia catalpifolia T. Gong ex D.Y. Read More

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http://dx.doi.org/10.1016/j.phytochem.2018.11.010DOI Listing
February 2019
2 Reads

Anti-inflammatory prenylbenzaldehyde derivatives isolated from Eurotium cristatum.

Phytochemistry 2019 Feb 5;158:120-125. Epub 2018 Dec 5.

School of Marine Sciences, Sun Yat-Sen University, Guangzhou, 510006, China; Key Laboratory of Functional Molecules from Oceanic Microorganisms (Sun Yat-Sen University), Department of Education of Guangdong Province, Guangzhou, 510006, China.

Two undescribed prenylbenzaldehyde derivatives, cristaldehydes A and B, and an undescribed quinone derivative, cristaquinone A, along with seven known compounds were isolated from the fungus Eurotium cristatum. The structures of undescribed compounds were determined by spectroscopic analysis including NMR, HR-ESIMS, and single-crystal X-ray diffraction. This is the first report of identification of a dibenzannulated 6,6-spiroketal derivative, cristaldehyde B, in a natural product. Read More

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http://dx.doi.org/10.1016/j.phytochem.2018.11.017DOI Listing
February 2019
16 Reads

Use of multivariate NMR analysis in the content prediction of hemicellulose, cellulose and lignin in greenhouse crop residues.

Phytochemistry 2019 Feb 28;158:110-119. Epub 2018 Nov 28.

Department of Chemistry and Physics, Research Centre CIAIMBITAL, University of Almería, Ctra. Sacramento, s/n, 04120, Almería, Spain. Electronic address:

We have introduced the use of multivariate NMR analysis in the development of accurate and robust prediction models, potentially arising from a correlation between soluble metabolite profiles and cell wall composition, for the determination of hemicellulose, cellulose and lignin contents in 8 species of greenhouse crop residues. The present paper demonstrates that discriminant buckets coming from a PLS-DA model in combination with linear models provide a useful and rapid tool for the determination of cell wall composition of these plant wastes. Regularized linear regression methods have also been applied to avoid overfitting, producing improved models specifically for lignin and cellulose determinations. Read More

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http://dx.doi.org/10.1016/j.phytochem.2018.11.013DOI Listing
February 2019
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Manipulation of oxalate metabolism in plants for improving food quality and productivity.

Phytochemistry 2019 Feb 28;158:103-109. Epub 2018 Nov 28.

National Institute of Plant Genome Research, New Delhi, 110067, India. Electronic address:

Oxalic acid is a naturally occurring metabolite in plants and a common constituent of all plant-derived human diets. Oxalic acid has diverse unrelated roles in plant metabolism, including pH regulation in association with nitrogen metabolism, metal ion homeostasis and calcium storage. In plants, oxalic acid is also a pathogenesis factor and is secreted by various fungi during host infection. Read More

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http://dx.doi.org/10.1016/j.phytochem.2018.10.029DOI Listing
February 2019
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Diterpene synthases facilitating production of the kaurane skeleton of eriocalyxin B in the medicinal plant Isodon eriocalyx.

Phytochemistry 2019 Feb 26;158:96-102. Epub 2018 Nov 26.

State Key Laboratory of Phytochemistry and Plant Resources in West China, Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, Yunnan, China. Electronic address:

The Isodon plants (Lamiaceae) have been used in traditional Chinese medicine to alleviate sufferings from inflammations and cancers. This feature has been attributed to the presence of pharmacologically active ent-kaurane diterpenoids such as eriocalyxin B and oridonin. The Isodon eriocalyx (Dunn) Kudô species native to southwest China can accumulate a particularly high content of ent-kaurane diterpenoids (∼1. Read More

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http://dx.doi.org/10.1016/j.phytochem.2018.11.015DOI Listing
February 2019
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A syn-ent-labdadiene derivative with a rare spiro-β-lactone function from the male cones of Wollemia nobilis.

Phytochemistry 2019 Feb 24;158:91-95. Epub 2018 Nov 24.

Dipartimento di Biologia Ambientale, Università di Roma "La Sapienza", Piazzale Aldo Moro 5, 00185 Roma, Italy.

An undescribed labdane-like diterpene with a rare spiro-β-lactone function was identified from the ethanol extract of the male cones of the coniferous tree Wollemia nobilis. This spirolabdadienolide (IUPAC name: syn-ent-8(17),13-labdadien-19,18-olid-15-oic acid methyl ester; trivial name: wollemolide), was isolated by means of traditional and high performance chromatography techniques and structurally elucidated through NMR and MS. In addition, six further known metabolites were evidenced in the extract. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00319422183049
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http://dx.doi.org/10.1016/j.phytochem.2018.11.012DOI Listing
February 2019
8 Reads

Floral scent in Iris planifolia (Iridaceae) suggests food reward.

Phytochemistry 2019 Feb 24;158:86-90. Epub 2018 Nov 24.

University of Palermo, Department of Biological, Chemical and Pharmaceutical Sciences and Technologies, Viale delle Scienze, 90128, Palermo, Italy.

Iris species can adopt different pollination strategies to attract their pollinators, generalized shelter-mimicking, specialized deceptive sexual-mimicking or food-rewarding. As attractive stimuli, Iris flowers may use their colours, large-size, symmetry, and volatile organic compounds (VOCs). However, relatively few studies investigated Iris floral olfactory cues in the context of plant-visitor/pollinator interactions. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00319422183040
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http://dx.doi.org/10.1016/j.phytochem.2018.11.011DOI Listing
February 2019
15 Reads

Diterpenoids from the Chinese liverwort Frullania hamatiloba and their Nrf2 inducing activities.

Phytochemistry 2019 Feb 24;158:77-85. Epub 2018 Nov 24.

Department of Natural Product Chemistry, Key Lab of Chemical Biology of Ministry of Education, School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China. Electronic address:

Six previously undescribed labdane diterpenoids, frullanians A-F, along with five known diterpenoids, were isolated from the Chinese liverwort Frullania hamatiloba Stephani. Their structures were determined using NMR data, electronic circular dichroism (ECD) calculations as well as the single crystal X-ray diffraction measurement. NAD(P)H: QR (quinone reductase) assay demonstrated that frullanian D and four known compounds displayed antioxidant effect mediated via Nrf2 (Nuclear factor-erythroid 2-related factor 2) induction. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00319422183053
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http://dx.doi.org/10.1016/j.phytochem.2018.11.002DOI Listing
February 2019
15 Reads
2.547 Impact Factor

Stigmastane-type steroids with unique conjugated Δ diene and highly oxygenated side chains from the twigs of Vernonia amygdalina.

Phytochemistry 2019 Feb 24;158:67-76. Epub 2018 Nov 24.

Fujian Provincial Key Laboratory of Innovative Drug Target, School of Pharmaceutical Sciences, Xiamen University, Xiamen, 361005, PR China. Electronic address:

Veramyosides A-J, eleven undescribed stigmastane-type steroids, including one aglycone and ten glycosides, along with three known homologues were isolated from the twigs of Vernonia amygdalina Delile (compositae). All compounds featured a stigmastane-type steroid skeleton with a unique conjugated Δ diene segment and highly oxygenated side chains with a γ-lactone or an α, β-unsaturated five-membered lactone ring. The structures of veramyosides A-J and their absolute configurations were unambiguously elucidated by HR-ESI-MS, extensive NMR spectroscopy, in situ dimolybdenum CD methods, modified Mosher's method, quantum chemical calculation of their ECD curves, and CD comparison methods on basis of their biogenetic pathway. Read More

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http://dx.doi.org/10.1016/j.phytochem.2018.10.036DOI Listing
February 2019
2 Reads

Enhanced production of unusual triterpenoids from Kadsura angustifolia fermented by a symbiont endophytic fungus, Penicillium sp. SWUKD4.1850.

Phytochemistry 2019 Feb 23;158:56-66. Epub 2018 Nov 23.

Key Laboratory of Eco-environments in Three Gorges Reservoir Region (Ministry of Education), School of Life Science, Southwest University, Chongqing 400715, China. Electronic address:

Highly oxygenated schitriterpenoids are interesting for study of their structures, bioactivities and synthesis. From Kadsura angustifolia fermented by an associated symbiotic endophytic fungus, Penicillium sp. SWUKD4. Read More

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http://dx.doi.org/10.1016/j.phytochem.2018.11.005DOI Listing
February 2019
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LC-MS-guided isolation of anti-inflammatory 2-(2-phenylethyl)chromone dimers from Chinese agarwood (Aquilaria sinensis).

Phytochemistry 2019 Feb 17;158:46-55. Epub 2018 Nov 17.

Modern Research Center for Traditional Chinese Medicine, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, People's Republic of China. Electronic address:

Fifteen previously undescribed 2-(2-phenylethyl)chromone dimers, along with two known analogues were isolated from Chinese agarwood (Aquilaria sinensis) by a LC-MS-guided fractionation procedure. Their structures were elucidated on the basis of spectroscopic and spectrometric data (1D and 2D NMR, IR, and HRESIMS). The isolated compounds exhibited significant inhibition of nitric oxide production in lipopolysaccharide-stimulated RAW264. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00319422183050
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http://dx.doi.org/10.1016/j.phytochem.2018.11.003DOI Listing
February 2019
9 Reads
2.547 Impact Factor