746,665 results match your criteria Physiological measurement[Journal]
Yonsei Med J 2019 Jan;60(1):56-64
Division of Cardiovascular Surgery, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Korea.
Purpose: Details on the hemodynamic differences among Fontan operations remain unclear according to respiratory and cardiac cycles. This study was undertaken to investigate hemodynamic characteristics in different types of Fontan circulation by quantification of blood flow with the combined influence of cardiac and respiratory cycles.
Materials And Methods: Thirty-five patients [10 atriopulmonary connections (APC), 13 lateral tunnels (LT), and 12 extracardiac conduits (ECC)] were evaluated, and parameters were measured in the superior vena cava, inferior vena cava (IVC), hepatic vein (HV), baffles, conduits, and left and right pulmonary artery. Read More
Transbound Emerg Dis 2018 Dec 16. Epub 2018 Dec 16.
Department of Microbiology, Western College of Veterinary Microbiology, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
Many viruses that cause serious and often fatal disease in humans have spilled over from bats. Recent evidence suggests that stress may enhance virus shedding by bats increasing the possibility of transmission to other species. To understand the reasons for spillover it is therefore important to determine the molecular pathways that link stress to virus reactivation and shedding in bats. Read More
Appl Microbiol Biotechnol 2018 Dec 15. Epub 2018 Dec 15.
School of Life Sciences, BK21 Plus KNU Creative BioResearch Group, Kyungpook National University, Daegu, 41566, Korea.
Periplanetasin-2 is a 15-mer antimicrobial peptide (AMP), derived from the American cockroach Periplaneta americana. This novel AMP exhibits potent antibacterial effect against several pathogenic bacteria including Escherichia coli. Distinct from the targeting cell membrane, which is the general antibacterial mechanism of AMP, periplanetasin-2 exerts its antibacterial activity via apoptosis-like death, which is physiologically and mechanistically similar to eukaryotic apoptosis. Read More
Forensic Sci Med Pathol 2018 Dec 15. Epub 2018 Dec 15.
Department of Legal Medicine, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, 634-8521, Japan.
Ventricular septal defect (VSD) generally has a good prognosis unless complicated by heart failure (HF). We report a case of sudden infant death because of clinically undiagnosed VSD in a seemingly healthy 16-day-old boy. Although a cardiac murmur was auscultated at birth, detailed clinical examination was not performed. Read More
Environ Sci Pollut Res Int 2018 Dec 15. Epub 2018 Dec 15.
Ministry of Education and Jiangxi Key Laboratory of Crop Physiology, Ecology and Genetic Breeding, Jiangxi Agricultural University, Nanchang, 330045, China.
Greenhouse gas emissions from agricultural soils contribute substantially to global atmospheric composition. Nitrous oxide (NO) is one important greenhouse gas induces global warming. Nitrification inhibitors (NI) or biochar can be effective soil NO emission mitigation strategies for agricultural soils. Read More
Mol Biol Rep 2018 Dec 15. Epub 2018 Dec 15.
Department of Biochemistry, University of Kerala, Thiruvananthapuram, Kerala, India.
The current treatment system in cancer therapy, which includes chemotherapy/radiotherapy is expensive and often deleterious to surrounding healthy tissue. Presently, several medicinal plants and their constituents are in use to manage the development and progression of these diseases.They have been found effective, safe, and less expensive. Read More
J Mol Med (Berl) 2018 Dec 15. Epub 2018 Dec 15.
Morehouse School of Medicine, Cardiovascular Research Institute, 720 Westview Drive SW, Atlanta, GA, 30310, USA.
Ischemic heart disease (IHD) is caused by the narrowing of arteries that work to provide blood, nutrients, and oxygen to the myocardial tissue. The worldwide epidemic of IHD urgently requires innovative treatments despite the significant advances in medical, interventional, and surgical therapies for this disease. Angiogenesis is a physiological and pathophysiological process that initiates vascular growth from pre-existing blood vessels in response to a lack of oxygen. Read More
Virology 2018 Dec 13;528:30-36. Epub 2018 Dec 13.
The Arbovirus Laboratory, Wadsworth Center, New York State Department of Health, Slingerlands, NY, USA; Department of Biomedical Sciences, State University of New York at Albany School of Public Health, Albany, NY, USA.
Rabensburg virus (RBGV; Flaviviridae, Flavivirus) has been classified as both a novel flavivirus and a unique lineage of West Nile virus (WNV). RBGV and WNV share approximately 76% sequence homology, yet RBGV does not replicate to high viral titers within vertebrate cell lines at physiological temperatures and has not been naturally isolated from a vertebrate host. These unique genetic and biological characteristics make RBGV a viable tool to identify the genetic determinants of flavivirus infectivity and fitness in vertebrate hosts. Read More
Respir Physiol Neurobiol 2018 Dec 13. Epub 2018 Dec 13.
Department of Physiopathology and Transplantations, Università degli Studi di Milano, Milan, Italy.
In 9 anesthetized, paralyzed dogs lung and chest-wall standard (viscous resistance, Rint, and quasi-static elastance, Est) and viscoelastic parameters (resistance, Rvel, and time constant, τvel) were measured in the supine posture before and after rib-cage block, after application of an expiratory threshold load, and after 75° head-up tilting before and after wide chest opening. Lung and chest-wall τvel were the same under all conditions. Rvel was independent of volume and posture, and greater for the lung. Read More
Conscious Cogn 2018 Dec 12;67:86-97. Epub 2018 Dec 12.
Fondazione Santa Lucia, IRCCS, Rome, Italy; SCNLab, Department of Psychology, University of Rome "La Sapienza", Rome, Italy. Electronic address:
Observing others' pain may induce a reaction called personal distress that may be influenced by top-down (imagine self or other in pain, i.e., self- vs other-oriented stance) and bottom-up (physical perspective of those who suffer, i. Read More
Cognition 2018 Dec 13;184:11-18. Epub 2018 Dec 13.
School of Psychology, University of Newcastle, Australia.
The study of non-human primates has been foundational in understanding the neural origins of human decision processes, yet the approach rests on the assumption that one can validly extrapolate from the animal to the human. In the context of decision making, this requires constancy across species in physiological and cognitive processes. The former cannot be experimentally validated and therefore remains assumed, and recent findings have called into question the latter: non-human primates become increasingly urgent as the time spent making a decision increases, but humans do not; from a normative perspective, monkeys are making closer-to-optimal decisions than humans. Read More
Physiol Behav 2018 Dec 13. Epub 2018 Dec 13.
Iranian National Center for Addiction Studies (INCAS), Tehran University of Medical Sciences, Tehran, Iran; Department of Neuroscience, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran; Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran; Institute for Cognitive Science Studies (ICSS), Tehran, Iran; Endocrinology and Metabolism Research Institute, Tehran University of Medical Science, Tehran, Iran. Electronic address:
Working memory (WM) system, temporarily stores information and uses this information for complex cognitive tasks. WM connects memory, emotional feelings and perception. Evidence compelling that N-methyl d-aspartate receptor (NMDAR) expression relatively affect WM performance in animal models. Read More
Clin Chim Acta 2018 Dec 13. Epub 2018 Dec 13.
Laboratory of Clinical Nutrition and Medicine, Kagawa Nutrition University, Tokyo, Japan.
We have long thought that remnant lipoproteins (RLP) in the postprandial plasma contain CM remnants (exogenous remnants; RLP-apoB48) and VLDL remnants (endogenous remnants; RLP-apoB100) of different origin, i.e. produced in the intestine and liver, respectively. Read More
J Pharm Sci 2018 Dec 13. Epub 2018 Dec 13.
Department of Physiological Sciences, Piracicaba Dental School, University of Campinas, Piracicaba, São Paulo, Brazil. Electronic address:
The use of permeation enhancers such as microneedles (MNs) to increase drug penetration across intraoral mucosa has increased in recent years. Permeation studies, commonly performed using vertical diffusion cells, are a well-established way to preview formulations and enhance their performance during the development stage. However, to our knowledge, the existing intraoral mucosa barrier models do not permit permeation using MNs-pretreated mucosa, due to their insufficient thickness. Read More
Eur J Pharmacol 2018 Dec 13. Epub 2018 Dec 13.
Edward Via Virginia College of Osteopathic Medicine, Technical University, Darmstadt, Germany; Virginia-Maryland College of Veterinary MedicineVirginia Tech, Blacksburg, VA, USA; School of Neuroscience, Virginia Tech, Blacksburg, VA, USA. Electronic address:
N-methyl D-aspartate (NMDA) receptors play a crucial role in normal brain function, pathogenesis of neurodegenerative and psychiatric disorders. Functional tetra-heteromeric NMDA receptor contains two obligatory GluN1 subunits and two identical or different non-GluN1 subunits that evolve from six different genes including four GluN2 (A-D) and two GluN3 (A-B) subunits. Since NMDA receptors confer varied physiological properties and spatiotemporal distributions in the brain, pharmacological agents that target NMDA receptors with specific GluN2 subunits have significant potential for therapeutic applications. Read More
J Orthop Sci 2018 Dec 12. Epub 2018 Dec 12.
Dept. of Orthopedic Surgery, Keio University School of Medicine, Shinanomachi 35, Shinjuku, Tokyo, #160-8582, Japan. Electronic address:
Background: Some patients suffer from long-lasting symptoms after whiplash injury. However, there are few reports on the long-term changes in the cervical spine after whiplash injury using imaging tests. The purpose of this longitudinal study was to determine the changes on MRI of the cervical spine 20 years after whiplash injury, and to examine the relationships between changes in the cervical spine on MRI and changes in related clinical symptoms. Read More
J Voice 2018 Dec 12. Epub 2018 Dec 12.
Department of Phoniatrics and Speech Pathology, Clinic for Otorhinolaryngology, Head and Neck Surgery, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Objective: Neck muscle dysfunction has been considered as risk factor or consequence of voice disorders. This study investigates the correlation between neck and voice-related subjective symptoms in patients with voice disorders.
Study Design: Retrospective case-control study. Read More
Clin Nutr 2018 Nov 30. Epub 2018 Nov 30.
Servicio de Geriatría, Hospital Universitario Ramón y Cajal (IRYCIS), Madrid, Spain. Electronic address:
Recent definitions of malnutrition include low muscle mass within its diagnostic criteria. In fact, malnutrition is one of the main risk factors of skeletal muscle loss contributing to the onset of sarcopenia. However, differences in the screening and diagnosis of skeletal muscle loss, especially as a result of malnutrition in clinical and community settings, still occur mainly as techniques and thresholds used vary in clinical practice. Read More
Brain Cogn 2018 Dec 12. Epub 2018 Dec 12.
Yale Stress Center, Department of Psychiatry, Yale University, 2 Church Street South, Suite 209, New Haven, CT 06519, United States. Electronic address:
Stress can strongly influence what we learn and remember, including by making memories stronger. Experiments probing stress effects on hippocampus-dependent memory in rodents have revealed modulatory factors and physiological mechanisms by which acute stress can enhance long-term memory. However, extending these findings and mechanisms to understand when stress will enhance declarative memory in humans faces important challenges. Read More
J Arthroplasty 2018 Nov 23. Epub 2018 Nov 23.
Outcomes Unit, Primary Joint Unit, Department of Orthopaedics, Musgrave Park Hospital, Belfast, United Kingdom.
Background: Total knee arthroplasty designs can be categorized by bearing design and fixation method. The mobile-bearing concept was developed with the aim of increasing longevity and improving function by reduced polyethylene wear and closer replication of physiological knee motion. Cementless fixation has the goal of achieving a long-lasting "biological" fixation between prosthesis and bone. Read More
Prog Biophys Mol Biol 2018 Dec 12. Epub 2018 Dec 12.
University of Göttingen, 3rd Institute of Physics - Biophysics, 37077, Göttingen, Germany. Electronic address:
Cardiomyocyte and stroma cell cross-talk is essential for the formation of collagen-based engineered heart muscle, including engineered human myocardium (EHM). Fibroblasts are a main component of the myocardial stroma. We hypothesize that fibroblasts, by compacting the surrounding collagen network, support the self-organization of cardiomyocytes into a functional syncytium. Read More
Neuron 2018 Dec 6. Epub 2018 Dec 6.
Center for Neural Science, New York University, New York, NY 10003, USA; Shanghai Research Center for Brain Science and Brain-Inspired Intelligence, Shanghai 201210, China. Electronic address:
Computational modeling of brain mechanisms of cognition has largely focused on the cortex, but recent experiments have shown that higher-order nuclei of the thalamus participate in major cognitive functions and are implicated in psychiatric disorders. Here, we show that a pulvino-cortical circuit model, composed of the pulvinar and two cortical areas, captures several physiological and behavioral observations related to the macaque pulvinar. Effective connections between the two cortical areas are gated by the pulvinar, allowing the pulvinar to shift the operation regime of these areas during attentional processing and working memory and resolve conflict in decision making. Read More
Curr Opin Insect Sci 2018 Dec 27;30:73-78. Epub 2018 Sep 27.
Laboratoire « Signalisation Fonctionnelle des Canaux Ioniques et Récepteurs » (SiFCIR), UPRES-EA2647 USC INRA 1330, SFR 4207 QUASAV, UFR Sciences, Université d'Angers, 2 Bld Lavoisier, 49045 Angers Cedex 01, France. Electronic address:
Insecticides were used as pest management tools for a long time. The appearance of resistant insects has led the scientific community to rethink their use and to study the mechanisms underlying the resistance in order to circumvent it. However, we know now that sublethal doses of insecticide induce many effects which should be taken into account for pest control. Read More
J Biomech 2018 Dec 7. Epub 2018 Dec 7.
Department of Surgery, Division of Otolaryngology-Head and Neck Surgery, University of Wisconsin-Madison, Madison, WI, United States. Electronic address:
The design of cell-based therapies for vocal fold tissue engineering requires an understanding of how cells adapt to the dynamic mechanical forces found in the larynx. Our objective was to compare mechanotransductive processes in therapeutic cell candidates (mesenchymal stromal cells from adipose tissue and bone marrow, AT-MSC and BM-MSC) to native cells (vocal fold fibroblasts-VFF) in the context of vibratory strain. A bioreactor was used to expose VFF, AT-MSC, and BM-MSC to axial tensile strain and vibration at human physiological levels. Read More
Prostaglandins Leukot Essent Fatty Acids 2019 Jan 3;140:47-50. Epub 2018 Dec 3.
Laboratory of Molecular Signaling, National Institute of Alcohol Abuse and Alcoholism, National Institutes of Health, 5625 Fishers Lane, Room 3N07, Bethesda, MD 20892-9410, United States.
Shortly after the discovery that linoleic acid was an essential fatty acid in 1930, α-linolenic acid also was reported to prevent the fatty acid deficiency syndrome in animals. However, several prominent laboratories could not confirm the findings with α-linolenic acid, and as a result there was a loss of interest in omega-3 fatty acids in lipid research. Even the findings that a prostaglandin can be synthesized from eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) is necessary for optimum retinal function generated only limited interest in omega-3 fatty acids. Read More
Prostaglandins Leukot Essent Fatty Acids 2019 Jan 22;140:18-33. Epub 2018 Nov 22.
Department of Physiological Sciences, Faculty of Sciences, Stellenbosch University Main Campus, Stellenbosch 7600, Western Cape, Republic of South Africa. Electronic address:
Globally, breast cancer continues to be a major concern in women's health. Lifestyle related risk factors, specifically excess adipose tissue (adiposity) has reached epidemic proportions and has been identified as a major risk factor in the development of breast cancer. Dysfunctional adipose tissue has evoked research focusing on its association with metabolic-related conditions, breast cancer risk and progression. Read More
Carbohydr Polym 2019 Feb 19;206:641-652. Epub 2018 Nov 19.
Institute of Polymer Chemistry, Johannes Kepler University Linz, 4040 Linz, Austria.
Camptothecin (CPT), a potent anticancer drug with known antiviral activity, is halted of clinical use. Few drug delivery systems of CPT are approved for therapy. Hereby, we propose the encapsulation of hydrophobic CPT in the inner core of cellulose nanoaggregates for sustained release with retaining of antiproliferative activity. Read More
Carbohydr Polym 2019 Feb 6;206:149-162. Epub 2018 Nov 6.
School of Food and Biological Engineering, Hefei University of Technology, Hefei, 230009, China. Electronic address:
The present study investigated the effects of a homogeneous Dendrobium huoshanense polysaccharide (GXG) on mucosal barrier function and microbiota composition in different intestinal regions of mice. Results exhibited, besides changing the intestinal physiological status, orally administrated GXG could improve the intestinal physical barrier function by modulating mucosal structures and up-regulating the expression of tight junction proteins, reinforce the intestinal biochemical barrier function by elevating the expression and secretion of mucin-2, β-defensins and sIgA, and regulate the intestinal immunological barrier function by stimulating the production of cytokines and the functional development of immune cells. Simultaneously, GXG could differentially impact the composition and metabolism of microbiota along intestinal tract. Read More
Chemosphere 2018 Dec 6;219:526-537. Epub 2018 Dec 6.
Department of Environmental Toxicology, The Institute of Environmental and Human Health, Texas Tech University, Lubbock, TX 79416, USA.
Pyrethroids are potent neurotoxicants that may elicit multiple pathways of toxicity in non-target organisms. Comparative studies on the mechanistic and developmental effects of types I and II pyrethroids against non-target aquatic species are limited. This study assessed the effects of the two pyrethroid types against embryo-larval zebrafish (Danio rerio) at environmentally relevant and laboratory concentrations. Read More
Biomed Pharmacother 2018 Dec 12;110:717-726. Epub 2018 Dec 12.
Department of Anesthesiology, Affiliated Shanghai Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai 200233, China; Department of Anesthesiology, Tongzhou People's Hospital, Nantong 226300, China. Electronic address:
Background And Purpose: The aim of this study was to investigate the interactions between mGluR5 and NMDAR during the development of tolerance to the analgesic effect of chronic morphine following disruption of the link between mGluR5 and NMDAR.
Methods: For these experiments, mGluR5 knockout (KO) mice, Shank3 ΔC mutant mice and their littermate controls were used. Repeated morphine treatment through intrathecal injections (i. Read More
Biomed Pharmacother 2018 Dec 12;110:685-691. Epub 2018 Dec 12.
Department of Cardiology, Chongqing Hospital of Traditional Chinese Medicine, Chongqing 400021, PR China. Electronic address:
Objective: Salvanic Acid B (Sal B) was proved to show significant effect against fibrosis and myocardial injury. This study aimed to investigate the protective effects and the mechanisms of Sal B on myocardial fibrosis.
Methods: The mice were randomly assigned to five groups: control group, model group, positive group, low-dose group, high-dose group. Read More
Biomed Pharmacother 2018 Dec 12;110:667-676. Epub 2018 Dec 12.
Department of Pharmacology and Clinical Pharmacy, College of Medicine and Health Sciences, Sultan Qaboos University, P.O. Box 35, Al Khod, 123, Oman.
We assessed the effect of treatment with the dipeptidyl peptidase-4 inhibitor, sitagliptin, on adenine-induced chronic kidney disease (CKD). Six equal groups of rats were given either normal food or food mixed with adenine (0.25% w/w for five weeks) to induce CKD. Read More
Micron 2018 Nov 23;118:9-21. Epub 2018 Nov 23.
Biomedical Research Institute, National Institute of Industrial Science and Technology (AIST), Higashi 1-1-1, Tsukuba, Ibaraki, 305-8566, Japan. Electronic address:
Neural networking, including axon targeting and synapse formation, is the basis of various brain functions, including memory and learning. Diabetes-mellitus affects peripheral nerves and is known to cause fatty liver disease. Electron microscopy (EM) provides the resolution required to observe changes in fine subcellular structures caused by such physiological and pathological processes, but samples are observed in vacuum. Read More
Sleep Med Rev 2018 Nov 16;43:106-117. Epub 2018 Nov 16.
Department of Women's and Children's Health, Dunedin School of Medicine, University of Otago, New Zealand. Electronic address:
This review aimed to better understand the underlying physiology of the risks and benefits of bed-sharing. Eight databases were searched using terms relating to adult-infant/baby, bed-sharing/co-sleeping combined with outcome terms for physiology, sleep, cardiovascular, respiratory, temperature and behaviour. Of 836 papers identified, 59 papers representing 48 cohorts met inclusion criteria. Read More
J Mol Graph Model 2018 Dec 4;87:172-184. Epub 2018 Dec 4.
Laboratory of Quantum and Computational Chemistry, Faculty of Chemistry and Pharmacy, University of Sofia, 1 James Bourchier Blvd, 1164, Sofia, Bulgaria. Electronic address:
The study is focused on description of folate and several antifolates at physiological conditions. Knowledge of the molecular structure and dynamics is important for understanding their biological activity and therapeutic application. They are modelled in saline by atomistic molecular dynamics simulations and characterized in detail. Read More
Aquat Toxicol 2018 Dec 5;207:91-100. Epub 2018 Dec 5.
Climate Change Cluster, University of Technology Sydney, NSW, Australia.
Copper (Cu) is an essential micronutrient for plants and as such is vital to many metabolic processes. Nevertheless, when present at elevated concentrations, Cu can exert toxic effects on plants by disrupting protein functions and promoting oxidative stress. Due to their proximity to the urbanised estuaries, seagrasses are vulnerable to chemical contamination via industrial runoff, waste discharges and leachates. Read More
Plant Physiol Biochem 2018 Dec 10;135:160-166. Epub 2018 Dec 10.
Department of Horticultural Sciences and Center for Coffee Research & Education, Texas A&M University, TAMU 2133, College Station, TX, 77843, USA.
A greenhouse study comparing the physiological responses and uptake of coffee (Coffea arabica L.) plants to foliar applications of zinc sulfate (ZnSO) and zinc nano-fertilizer (ZnO NPs) was conducted with the aim to understand their effects on plant physiology. One-year old coffee plants were grown in greenhouse conditions and treated with two foliar applications of 10 mg/L of Zn as either zinc sulfate monohydrate (ZnSO ‧ HO) or zinc oxide nanoparticle (ZnO NPs 20% w/t) and compared to untreated control plants over the course of 45 days. Read More
Protist 2018 Nov 10;170(1):21-37. Epub 2018 Nov 10.
Department of Bioenergetics, Adam Mickiewicz University, Umultowska 89, 61-614 Poznan, Poland.
Plants, fungi, and some protists possess a more branched electron transport chain in their mitochondria compared to canonical one. In these organisms, the electron transport chain contains several rotenone-insensitive NAD(P)H dehydrogenases. Some are located on the outer surface, and others are located on the inner surface of the inner mitochondrial membrane. Read More
Child Abuse Negl 2018 Dec 12;88:288-297. Epub 2018 Dec 12.
Research Center for Child Development, College of Elementary Education, Capital Normal University, No.105 Xisan Huan Beilu, Beijing, 100048, China. Electronic address:
Background: To date whether the effects of parental corporal punishment (CP) on executive function (EF) distinct components are different is less clear. Moreover, theory and empirical work suggest that physiological regulation system may help to explain the individual differences in the developmental outcomes associated with parental CP.
Objective: This study examined the effects of parental CP on Chinese preschoolers' EF and whether the cortisol stress reactivity would moderate such effects. Read More
Prog Retin Eye Res 2018 Dec 12. Epub 2018 Dec 12.
Department of Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.
In the eye immune defenses must take place in a plethora of differing microenvironments ranging from the corneal and conjunctival epithelia facing the external environment to the pigmented connective tissue of the uveal tract containing smooth muscle, blood vessels and peripheral nerves to the innermost and highly protected neural retina. The extravascular environment of the neural retina, like the brain parenchyma, is stringently controlled to maintain conditions required for neural transmission. The unique physiological nature of the neural retina can be attributed to the blood retinal barriers (BRB) of the retinal vasculature and the retinal pigment epithelium, which both tightly regulate the transport of small molecules and restrict passage of cells and macromolecules from the circulation into the retina in a similar fashion to the blood brain barrier (BBB). Read More
J Pharmacol Toxicol Methods 2018 Dec 12. Epub 2018 Dec 12.
Office of Translational Science, Office of Clinical Pharmacology, Division of Applied Regulatory Science, U.S. Food and Drug Administration, Center for Drug Evaluation and Research, White Oak Federal Research Center, 10903 New Hampshire Ave, Silver Spring, MD 20993, USA. Electronic address:
Topical ophthalmic drugs are the most commonly used dosage form to treat diseases of the anterior segment of the eye. Although this dosage form has the advantages of ease of application, small volume dose, and rapid action and is largely devoid of systemic adverse effects, the bioavailability is low due to pre-corneal anatomical barriers and the nature of the drug formulation itself. Some complex generic formulations (suspensions, ointments, gels) for topical ophthalmic products face impediments to rapid regulatory approval because of the complex nature of the formulations and difficulties in determining bioequivalence with the innovator product. Read More
Front Neuroendocrinol 2018 Dec 12. Epub 2018 Dec 12.
MTA-ELTE Laboratory of Molecular and Systems Neurobiology, Department of Physiology and Neurobiology, Hungarian Academy of Sciences and Eötvös Loránd University, Budapest, Hungary; Laboratory of Neuromorphology, Department of Anatomy, Histology and Embryology, Semmelweis University, Budapest, Hungary; Department of Psychiatry and Psychotherapy, Semmelweis University, Budapest, Hungary. Electronic address:
Our knowledge on the bioavailability and actions of insulin-like growth factor-1 (IGF-1) has markedly expanded in recent years as novel mechanisms were discovered on IGF binding proteins (IGFBPs) and their ability to release IGF-1. The new discoveries allowed a better understanding of the endogenous physiological actions of IGF-1 and also its applicability in therapeutics. The focus of the present review is to summarize novel findings on the neuronal, neuroendocrine and neuroplastic actions of IGF-1 in the adult brain. Read More
Biochim Biophys Acta Biomembr 2018 Dec 12. Epub 2018 Dec 12.
Air Force Research Laboratory, 711th Human Performance Wing, Airman Systems Directorate, Bioeffects Division, Radio Frequency Bioeffects Branch, 4141 Petroleum Road, JBSA Fort Sam Houston, TX 78234, USA.
Nanosecond electric pulses have been shown to open nanopores in the cell plasma membrane by fluorescent imaging of calcium uptake and fluorescent dyes, including propidium (Pr) iodide and YO-PRO-1 (YP). Recently, we demonstrated that nsEPs also induce the phosphoinositide intracellular signaling cascade by phosphatidylinositol‑4,5‑bisphosphate (PIP) depletion resulting in physiological responses similar to those observed following stimulation of G-coupled receptors. In this paper, we explore the role of receptor- and store-operated calcium entry (ROCE/SOCE) mechanisms in the observed response of cells to nsEP. Read More
Immunology 2018 Dec 15. Epub 2018 Dec 15.
William Harvey Research Institute, Barts and the London, Queen Mary University of London, London, UK.
Healthy white adipose tissue (WAT) participates in regulating systemic metabolism, whilst dysfunctional WAT plays a prominent role in the development of obesity-associated comorbidities. Tissue resident immune cells are important for maintaining WAT homeostasis, including conventional dendritic cells (cDCs) which are critical in the initiation and regulation of adaptive immune responses. Due to phenotypic overlap with other myeloid cells, the distinct contribution of WAT cDCs has been poorly understood. Read More
J Anim Physiol Anim Nutr (Berl) 2018 Dec 14. Epub 2018 Dec 14.
Institute of Animal Nutrition, Freie Universität Berlin, Berlin, Germany.
The aim of the study was to investigate nutritional, physiological and immunological effects of a plant-derived blend of isoquinoline alkaloids (Sangrovit® Extra) in healthy dogs. Two groups of healthy, adult beagles (N = 10) were tested in a cross-over experiment, lasting two consecutive three-week periods. The experimental group received 1. Read More
Breast Cancer Res Treat 2018 Dec 14. Epub 2018 Dec 14.
Oncogenetics Group, Vall d'Hebron Institute of Oncology, VHIO, 08035, Barcelona, Spain.
Purpose: Disruption of splicing motifs by genetic variants can affect the correct generation of mature mRNA molecules leading to aberrant transcripts. In some cases, variants may alter the physiological transcription profile composed of several transcripts, and an accurate in vitro evaluation is crucial to establish their pathogenicity. In this study, we have characterized a novel PALB2 variant c. Read More
Anat Sci Int 2018 Dec 14. Epub 2018 Dec 14.
Department of Anatomy, College of Basic Medicine, Dalian Medical University, Dalian, China.
The myodural bridge (MDB) is a dense connective tissue that connects muscles with the cervical spinal dura mater via the posterior atlanto-occipital and atlato-axial interspaces. To date, the physiological function of the MDB has not been fully elucidated. Recent studies have identified the presence of the MDB in mammals, but very little information is available on the existence of the MDB in avifauna. Read More
Environ Sci Pollut Res Int 2018 Dec 14. Epub 2018 Dec 14.
Laboratory of Metabolomics and Isotope Analyses, Global Change Research Institute, Czech Academy of Sciences, Bělidla 986/4a, 603 00, Brno, Czech Republic.
Early stages of ontogenesis determining subsequent growth, development, and productivity of crops can be affected by wastewater and sludge contaminated with pharmaceuticals. Diclofenac (DCF) and paracetamol (PCT; both 0.0001 to 10 mg/L) did not affect seed germination and primary root length of onion, lettuce, pea, and tomato. Read More
Sci Rep 2018 Dec 14;8(1):17871. Epub 2018 Dec 14.
Charles E. Schmidt College of Medicine, Department of Biomedical Science, Florida Atlantic University, Boca Raton, FL, USA.
Major complications and mortality from Plasmodium falciparum malaria are associated with cytoadhesion of parasite-infected erythrocytes (IE). The main parasite ligands for cytoadhesion are members of the P. falciparum erythrocyte membrane protein 1 (PfEMP1) family. Read More
BMJ Open 2018 Dec 14;8(12):e025761. Epub 2018 Dec 14.
Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK.
Introduction: Cognitive-behavioural therapy (CBT) is a psychological therapy that has been used to improve patient well-being across multiple mental and physical health problems. Its effectiveness has been examined in thousands of randomised control trials that have been synthesised into hundreds of systematic reviews. The aim of this overview is to map, synthesise and assess the reliability of evidence generated from these systematic reviews of the effectiveness of CBT across all health conditions, patient groups and settings. Read More