759,695 results match your criteria Physiological and biochemical zoology : PBZ[Journal]


Carbonic anhydrase activity as a potential biomarker for acute exposure to copper in corals.

Chemosphere 2019 Apr 15;227:598-605. Epub 2019 Apr 15.

Instituto Coral Vivo, Rua dos Coqueiros, Parque Yaya, Santa Cruz Cabrália, BA, 45807-000, Brazil; Instituto de Ciências Biológicas, Universidade Federal do Rio Grande, Av. Itália, Km 8, Rio Grande, RS, 96203-900, Brazil. Electronic address:

Coral reefs are subjected to climate change and are severely impacted by human activities, with copper (Cu) being a relevant physiological stressor for corals at local scale. The ecological relevance of parameters measured at biochemical or cellular level is now considered an extremely important feature in environmental studies, and can be used as early warning signs of environmental degradation. In this context, the effects of acute exposure (96 h) to Cu were assessed on the maximum photochemical efficiency of zooxanthellae (Fv/Fm) and on the activity of key enzymes [carbonic anhydrase (CA) and Ca-ATPase] involved in coral physiology using the scleractinian coral Mussismilia harttii as a biological model. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00456535193074
Publisher Site
http://dx.doi.org/10.1016/j.chemosphere.2019.04.089DOI Listing
April 2019
1 Read

CRAC channels and disease - From human CRAC channelopathies and animal models to novel drugs.

Authors:
Stefan Feske

Cell Calcium 2019 Mar 11;80:112-116. Epub 2019 Mar 11.

Department of Pathology, New York University School of Medicine, New York, NY, 10016, USA. Electronic address:

Ca release-activated Ca (CRAC) channels are intimately linked with health and disease. The gene encoding the CRAC channel, ORAI1, was discovered in part by genetic analysis of patients with abolished CRAC channel function. And patients with autosomal recessive loss-of-function (LOF) mutations in ORAI1 and its activator stromal interaction molecule 1 (STIM1) that abolish CRAC channel function and store-operated Ca entry (SOCE) define essential functions of CRAC channels in health and disease. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ceca.2019.03.004DOI Listing

Comparative proteomic analysis of two sesame genotypes with contrasting salinity tolerance in response to salt stress.

J Proteomics 2019 Apr 19. Epub 2019 Apr 19.

Key Laboratory of Biology and Genetic Improvement of Oil Crops, Ministry of Agriculture, Oil Crops Research Institute, Chinese Academy of Agricultural Sciences, Wuhan 430062, China. Electronic address:

Sesame is one of the most important oilseed crops and has high nutritional value. The yield and quality of sesame are severely affected by high salinity in coastal and semi-arid/arid regions. In this study, the phenotypic, physiological, and proteomic changes induced by salt treatment were analyzed in salt-tolerant (G441) and salt-sensitive (G358) seedlings. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jprot.2019.04.017DOI Listing

Functional implementation of a linear glycolysis for sugar catabolism in Pseudomonas putida.

Metab Eng 2019 Apr 19. Epub 2019 Apr 19.

The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, 2800 Kongens Lyngby, Denmark. Electronic address:

The core metabolism for glucose assimilation of the soil bacterium and platform strain Pseudomonas putida KT2440 has been reshaped from the native, cyclically-operating Entner-Doudoroff (ED) pathway to a linear Embden-Meyerhof-Parnas (EMP) glycolysis. The genetic strategy deployed to obtain a suitable host for the synthetic EMP route involved not only eliminating enzymatic activities of the ED pathway, but also erasing peripheral reactions for glucose oxidation that divert carbon skeletons into the formation of organic acids in the periplasm. Heterologous glycolytic enzymes, recruited from Escherichia coli, were genetically knocked-in in the mutant strain to fill the metabolic gaps for the complete metabolism of glucose to pyruvate through a synthetic EMP route. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ymben.2019.04.005DOI Listing

Nitric oxide and interactions with reactive oxygen species in the development of melanoma, breast, and colon cancer: A redox signaling perspective.

Nitric Oxide 2019 Apr 19. Epub 2019 Apr 19.

New York University School of Medicine, New York, NY, USA.

Cancer development is closely related to chronic inflammation, which is associated with identifiable markers of tumor progression, such as uncontrolled cell proliferation, angiogenesis, genomic instability, chemotherapeutic resistance, and metastases. Redox processes mediated by reactive oxygen species (ROS) and nitric oxide (NO) within the inflammatory tumor microenvironment play an essential role in directly influencing intercellular and intracellular signaling. These reactive species originating in the cancer cell or its microenvironment, mediate the epithelial-mesenchymal transition (EMT) and the mesenchymal-epithelial transition (MET). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.niox.2019.04.009DOI Listing

A sub-chronic Xysmalobium undulatum hepatotoxicity investigation in HepG2/C3A spheroid cultures compared to an in vivo model.

J Ethnopharmacol 2019 Apr 19:111897. Epub 2019 Apr 19.

Pharmacen™, Centre of Excellence for Pharmaceutical Sciences, North-West University, Private Bag X6001, Potchefstroom, 2520, South Africa; Department of Biochemistry and Molecular Biology, University of Southern Denmark, DK-5230, Odense M, Denmark; Celvivo IVS, Blommenslyst, Denmark. Electronic address:

Ethnopharmacology Relevance: Traditional herbal medicines are utilized by 27 million South Africans. Xysmalobium undulatum (Uzara) is one of the most widely used traditional medicinal plants in Southern Africa. A false belief in the safety of herbal medicine may result in liver injury. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jep.2019.111897DOI Listing

Effect of Endotracheal Intubation and Supraglottic Airway Device Placement during Cardiopulmonary Resuscitation on Carotid Blood Flow over Resuscitation Time: An Experimental Porcine Cardiac Arrest Study.

Resuscitation 2019 Apr 19. Epub 2019 Apr 19.

Department of Emergency Medicine, Seoul National University Boramae Medical Center, Seoul, Republic of Korea; Laboratory of Emergency Medical Services, Seoul National University Hospital Biomedical Research Institute, Seoul, Republic of Korea. Electronic address:

Background: Supraglottic airway devices (SGDs) are widely used during the resuscitation of out-of-hospital cardiac arrest (OHCA). The effect of SGDs on carotid blood flow (CBF) as resuscitation time passes is controversial. We assessed the effects of endotracheal intubation (ETI) and 3 types of SGD placement on CBF over time in prolonged resuscitation through an experimental porcine cardiac arrest study. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S03009572193013
Publisher Site
http://dx.doi.org/10.1016/j.resuscitation.2019.04.020DOI Listing
April 2019
1 Read

Untargeted LC-MS-based metabonomics revealed that aristolochic acid I induces testicular toxicity by inhibiting amino acids metabolism, glucose metabolism, β-oxidation of fatty acids and the TCA cycle in male mice.

Toxicol Appl Pharmacol 2019 Apr 19. Epub 2019 Apr 19.

Chinese Academy of Inspection and Quarantine, Institute of Chemicals Safety, Beijing, China. Electronic address:

As the main toxic component of aristolochic acid, aristolochic acid I (AAI) is primarily found in Aristolochiaceae plants such as Aristolochia, Aristolochia fangchi and Caulis aristolochiae manshuriensis. AAI has been proven to be carcinogenic, mutagenic and nephrotoxic. Although the role of AAI in testicular toxicity has been reported, its mechanism of action is unknown. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.taap.2019.04.014DOI Listing

The sensilla trichodea-biased EoblPBP1 binds sex pheromones and green leaf volatiles in Ectropis obliqua Prout, a geometrid moth pest that uses Type-II sex pheromones.

J Insect Physiol 2019 Apr 19. Epub 2019 Apr 19.

Key Laboratory of Tea Quality and Safety Control, Ministry of Agriculture, Tea Research Institute, Chinese Academy of Agricultural Sciences, Hangzhou, 310008, China. Electronic address:

Pheromone-binding proteins (PBPs) are considered to play critical roles in sex pheromone detection. Lepidopteran moths can be divided into two taxa, those that use Type-I sex pheromones, such as C10-C18 unsaturated aldehydes, alcohols and acetates, and those that use Type-II pheromones, which are C17-C23 polyunsaturated hydrocarbons and their epoxide derivatives. To date, nearly all the characterized PBPs have been reported in moths with Type-I sex pheromones, and the physiological functions of PBPs in moths that use Type-II sex pheromones remains unclear. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jinsphys.2019.04.005DOI Listing

Faecal metabolites and Hair cortisol as biological markers of HPA-axis activity in the Rocky Mountain Goat.

Gen Comp Endocrinol 2019 Apr 19. Epub 2019 Apr 19.

Reproductive Physiology, Toronto Zoo, 361A Old Finch Avenue, Toronto, Ontario, M1B 5K7, Canada.

Monitoring glucocorticoid in faeces and hair is increasingly used in ecological studies and provides a powerful and minimally intrusive mean to identify physiological challenges faced by wild animals. Using a cortisol and a corticosterone immunoassays, we conducted an adrenocorticotropic (ACTH) challenge with five weekly repeated injections to validate the use of faecal glucocorticoid metabolites and hair cortisol concentration as biological markers of the HPA-axis activity in captive mountain goats (Oreamnos americanus). We also investigated the effect of endogenous (age, sex, reproductive status) and methodological (faecal sample collection date, freezing delay and hair type) variables on cortisol values using faecal and hair samples collected from marked wild mountain goats during a long-term study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ygcen.2019.04.022DOI Listing

Double Network Hydrogels that Mimic the Modulus, Strength and Lubricity of Cartilage.

Biomacromolecules 2019 Apr 22. Epub 2019 Apr 22.

The development of a hydrogel-based synthetic cartilage has the potential to overcome many limitations of current chondral defect treatments. Many efforts have attempted to replicate the unique characteristics of cartilage in hydrogels, but none simultaneously achieved high modulus, strength and toughness while maintaining the necessary hydration required for lubricity. Herein, double network (DN) hydrogels, composed of a poly(2-acrylamido-2-methylpropane sulfonic acid) (PAMPS) 1st network and a poly(N-isopropyl-acrylamide-co-acrylamide) [P(NIPAAm-co-AAm)] 2nd network, are evaluated as a potential off-the-shelf material for cartilage replacement. Read More

View Article

Download full-text PDF

Source
http://pubs.acs.org/doi/10.1021/acs.biomac.9b00237
Publisher Site
http://dx.doi.org/10.1021/acs.biomac.9b00237DOI Listing
April 2019
5 Reads

Rapid profiling of triglycerides in human breast milk using LESA-FTMS reveals new VLCFAs and differences within individuals.

Rapid Commun Mass Spectrom 2019 Apr 22. Epub 2019 Apr 22.

Nutrition and Bone Health group MRC HNR, Cambridge, CB1 9NL, United Kingdom.

Rationale: In this paper, we describe a novel method for preparing milk samples and profiling the triglyceride fraction from them. This method was used to explore how the triglyceride (TG) profile of milk modulates as lactation progresses and how the TG profile differs between breasts.

Methods: Fresh milk was spotted onto Whatman filter paper and air-dried. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/rcm.8465DOI Listing

Abundance and diversity of nitrogen-removing microorganisms in the UASB-anammox reactor.

PLoS One 2019 22;14(4):e0215615. Epub 2019 Apr 22.

College of Resources and Environmental Science, Xinjiang University, Urumqi, China.

Anaerobic ammonium oxidation is considered to be the most economical and low-energy biological nitrogen removal process. So far, anammox bacteria have not yet been purified from cultures. Some nitrogen-removing microorganisms cooperate to perform the anammox process. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215615PLOS

ORAI1/STIM1 Interaction Intervenes in Stroke and in Neuroprotection Induced by Ischemic Preconditioning Through Store-Operated Calcium Entry.

Stroke 2019 May;50(5):1240-1249

IRCCS SDN, Naples, Italy (L.A.).

Background and Purpose- Disturbance of endoplasmic reticulum (ER) Ca homeostasis causes neuronal cell injury in stroke. By contrast, ischemic preconditioning (IPC)-a brief sublethal ischemic episode affording tolerance to a subsequent ischemic insult-restores ER Ca homeostasis. Under physiological conditions, ER calcium content is continuously refilled by the interaction between the ER-located Ca sensor STIM (stromal interacting molecule) 1 and the plasma membrane channel ORAI1 (a structural component of the CRAC calcium channel)-2 key mediators of the store-operated calcium entry (SOCE) mechanism. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/STROKEAHA.118.024115DOI Listing

A vocabulary describing health-terms of movement quality - a phenomenological study of movement communication.

Disabil Rehabil 2019 Apr 22:1-10. Epub 2019 Apr 22.

e Department of Journalism and Communication , University Carlos III of Madrid , Madrid , Spain.

Purpose: The aim of the study was to develop a vocabulary targeting communication of health-terms of movement quality, establishing professional knowledge of a movement terminology usefull within rehabilitation.

Methods: A phenomenological study design was chosen, inviting movement experts working in rehabilitation to describe movement observations when a change into more functional, health related ways of moving appeared in the rehabilitation processes. 15 physiotherapy experts were recruited, five from the field of neurology, primary health care and psychiatry. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/09638288.2019.1
Publisher Site
http://dx.doi.org/10.1080/09638288.2019.1585970DOI Listing
April 2019
1 Read

Physiological Factors Which Influence Cognitive Performance in Military Personnel.

Hum Factors 2019 Apr 22:18720819841757. Epub 2019 Apr 22.

University of Canberra, Australian Capital Territory, Australia.

Objective: To identify and detail physiological factors that influence cognition in military personnel.

Background: Maintenance of cognitive and task performance is important under several scenarios, none more so than in a military context. Personnel are prepared for and trained to tolerate many of the stressors they encounter; however, consideration of stressors typically extends only as far as the physical, psychological, and environmental requirements of a given task. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0018720819841757DOI Listing

Peptoid microsphere coatings: The effects of helicity, temperature, pH, and ionic strength.

Biopolymers 2019 Apr 22:e23283. Epub 2019 Apr 22.

Ralph E. Martin Department of Chemical Engineering, University of Arkansas Fayetteville, Fayetteville, Arkansas.

Peptoids are peptidomimetic oligomers that predominantly harness similarities to peptides for biomimetic functionality. They have potential for use in biomedical applications and biosensors due to resistance to proteolytic degradation and low immunogenicity. The incorporation of chiral, aromatic side chains in the peptoid sequence allows for the formation of distinct secondary structures and self-assembly into supramolecular assemblies, including microspheres. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/bip.23283DOI Listing

Homozygous stop mutation in AHR causes autosomal recessive foveal hypoplasia and infantile nystagmus.

Brain 2019 Apr 22. Epub 2019 Apr 22.

Molecular Genetics Laboratory, Institute for Ophthalmic Research, University of Tuebingen, Tuebingen, Germany.

Herein we present a consanguineous family with three children affected by foveal hypoplasia with infantile nystagmus, following an autosomal recessive mode of inheritance. The patients showed normal electroretinography responses, no signs of albinism, and no anterior segment or brain abnormalities. Upon whole exome sequencing, we identified a homozygous mutation (c. Read More

View Article

Download full-text PDF

Source
https://academic.oup.com/brain/advance-article/doi/10.1093/b
Publisher Site
http://dx.doi.org/10.1093/brain/awz098DOI Listing
April 2019
1 Read

Anger Inhibition and Pain Modulation.

Ann Behav Med 2019 Apr 22. Epub 2019 Apr 22.

Department of Psychology, The University of Tulsa, Tulsa, OK, USA.

Background: The tendency to inhibit anger (anger-in) is associated with increased pain. This relationship may be explained by the negative affectivity hypothesis (anger-in increases negative affect that increases pain). Alternatively, it may be explained by the cognitive resource hypothesis (inhibiting anger limits attentional resources for pain modulation). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/abm/kaz016DOI Listing

Multi-Modal Signals for Analyzing Pain Responses to Thermal and Electrical Stimuli.

J Vis Exp 2019 Apr 5(146). Epub 2019 Apr 5.

Department of Medical Psychology, Ulm University.

The assessment of pain relies mostly on methods that require a person to communicate. However, for people with cognitive and verbal impairments, existing methods are not sufficient as they lack reliability and validity. To approach this problem, recent research focuses on an objective pain assessment facilitated by parameters of responses derived from physiology, and video and audio signals. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3791/59057DOI Listing

Mimicking a Space Mission to Mars Using Hindlimb Unloading and Partial Weight Bearing in Rats.

J Vis Exp 2019 Apr 4(146). Epub 2019 Apr 4.

Department of Neurology, Harvard Medical School - Beth Israel Deaconess Medical Center.

Rodent ground-based models are widely used to understand the physiological consequences of space flight on the physiological system and have been routinely employed since 1979 and the development of hind limb unloading (HLU). However, the next steps in space exploration now include to travel to Mars where the gravity is 38% of Earth's gravity. Since no human being has experienced this level of partial gravity, a sustainable ground-based model is necessary to investigate how the body, already impaired by the time spent in microgravity, would react to this partial load. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3791/59327DOI Listing

Health related quality of life in stroke patients and risk factors associated with patients for return to work.

Medicine (Baltimore) 2019 Apr;98(16):e15130

Department of Neurology.

To clarify dynamic change of quality of life (QOL) in patients with stroke after treatment, and to explore the predictors associated with return to work (RTW) within 48 weeks.Patients diagnosed with stroke were enrolled. All patients enrolled were asked to fill in the Short Form 36 Health Survey. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MD.0000000000015130DOI Listing

Effects of Water Immersion Methods on Postexercise Recovery of Physical and Mental Performance.

J Strength Cond Res 2019 Apr 16. Epub 2019 Apr 16.

Unit of Biology of Physical Activity, University of Jyväskylä, Jyväskylä, Finland.

Ahokas, EK, Ihalainen, JK, Kyröläinen, H, and Mero, AA. Effects of water immersion methods on postexercise recovery of physical and mental performance. J Strength Cond Res XX(X): 000-000, 2019-The aim of this study was to compare the effectiveness of 3 water immersion interventions performed after active recovery compared with active recovery only on physical and mental performance measures and physiological responses. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1519/JSC.0000000000003134DOI Listing

A major interspecies difference in the ionic selectivity of megakaryocyte Ca-activated channels sensitive to the TMEM16F inhibitor CaCCinh-A01.

Platelets 2019 Apr 22:1-5. Epub 2019 Apr 22.

a Department of Molecular and Cell Biology , University of Leicester , Leicester , UK.

TMEM16F is a surface membrane protein critical for platelet procoagulant activity, which exhibits both phospholipid scramblase and ion channel activities following sustained elevation of cytosolic Ca. The extent to which the ionic permeability of TMEM16F is important for platelet scramblase responses remains controversial. To date, only one study has reported the electrophysiological properties of TMEM16F in cells of platelet/megakaryocyte lineage, which observed cation-selectivity within excised patch recordings from murine marrow-derived megakaryocytes. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/09537104.2019.1
Publisher Site
http://dx.doi.org/10.1080/09537104.2019.1595560DOI Listing
April 2019
1 Read

Fabrication and characterization of pectin-based 3D porous scaffolds suitable for treatment of peritoneal adhesions.

J Biomed Mater Res A 2019 Apr 22. Epub 2019 Apr 22.

Institute of Chemistry of New Materials of National Academy of Sciences of Belarus, 220141, Minsk, 36 Skariny str., Republic of Belarus.

Formation of peritoneal adhesions is common complication after abdominal and pelvic surgery. They bear a significant health problem with an influence to quality of life and health care expenses. Promising approach for their prevention is using of biodegradable barrier films for physical separation of peritoneal surfaces. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jbm.a.36700DOI Listing

Lactation induces increased IPSC bursting in oxytocinergic neurons.

Physiol Rep 2019 Apr;7(8):e14047

Department of Cell and Molecular Biology, Tulane University, New Orleans, Louisiana.

Hypothalamic magnocellular neurosecretory cells (MNCs) undergo dramatic structural reorganization during lactation in female rats that is thought to contribute to the pulsatile secretion of oxytocin critical for milk ejection. MNCs from male rats generate robust bursts of GABAergic synaptic currents, a subset of which are onset-synchronized between MNC pairs, but the functional role of the IPSC bursts is not known. To determine the physiological relevance of IPSC bursts, we compared MNCs from lactating and non-lactating female rats using whole-cell recordings in brain slices. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.14814/phy2.14047DOI Listing

Fhod1, an actin-organizing formin family protein, is dispensable for cardiac development and function in mice.

Cytoskeleton (Hoboken) 2019 Apr 22. Epub 2019 Apr 22.

Department of Pharmacology, Faculty of Medicine, University of Miyazaki, Miyazaki 889-1692, Japan.

The formin family proteins have the ability to regulate actin filament assembly, thereby functioning in diverse cytoskeletal processes. Fhod3, a cardiac member of the family, plays a crucial role in development and functional maintenance of the heart. Although Fhod1, a protein closely-related to Fhod3, has been reported to be expressed in cardiomyocytes, the role of Fhod1 in the heart has still remained elusive. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cm.21523DOI Listing

3D static optical coherence elastography based on inverse compositional Gauss-Newton (IC-GN) digital volume correlation.

J Biophotonics 2019 Apr 22:e201800422. Epub 2019 Apr 22.

Department of Mechanical Engineering, Tianjin Key Laboratory of Modern Engineering Mechanics, Tianjin University, Tianjin, China.

The three-dimensional (3D) mechanical properties characterization of tissue is essential for physiological and pathological studies, as biological tissue is mostly heterogeneous and anisotropic. A digital volume correlation (DVC)-based 3D optical coherence elastography (OCE) method is developed to measure the 3D displacement and strain tensors. The DVC algorithm includes a zero-mean normalized cross-correlation criterion based coarse search regime, an inverse compositional Gauss-Newton fine search algorithm and a local ternary quadratic polynomial fitting strain calculation method. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jbio.201800422DOI Listing

The actions of ghrelin in the paraventricular nucleus: energy balance and neuroendocrine implications.

Ann N Y Acad Sci 2019 Apr 22. Epub 2019 Apr 22.

Laboratory of Neuroendocrinology, Department of Biophysics, Paulista Medical School, Federal University of São Paulo, São Paulo, Brazil.

Ghrelin is a peptide mainly produced and secreted by the stomach. Since its discovery, the impact of ghrelin on the regulation of food intake has been the most studied function of this hormone; however, ghrelin affects a wide range of physiological systems, many of which are controlled by the hypothalamic paraventricular nucleus (PVN). Several pathways may mediate the effects of ghrelin on PVN neurons, such as direct or indirect effects mediated by circumventricular organs and/or the arcuate nucleus. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/nyas.14087DOI Listing

Joint linkage and association mapping of complex traits in shrub willow (Salix purpurea L.).

Ann Bot 2019 Apr 22. Epub 2019 Apr 22.

Horticulture Section, School of Integrative Plant Science, Cornell University, Cornell AgriTech, Geneva, NY, USA.

Background And Aims: Increasing energy demands and the necessity to reduce greenhouse gas emissions are key motivating factors driving the development of lignocellulosic crops as an alternative to non-renewable energy sources. The effects of global climate change will require a better understanding of the genetic basis of complex adaptive traits to breed more resilient bioenergy feedstocks, like willow (Salix spp.). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/aob/mcz047DOI Listing

[Facilitative glucose transporters: expression, distribution and the relationship to diseases].

Sheng Li Xue Bao 2019 Apr;71(2):350-360

Institute of Basic Medical Sciences, Xi'an Medical University, Xi'an 710021, China.

Facilitative glucose transporters (GLUT) are proteins that mediate glucose transmembrane transport in the form of facilitated diffusion, which play an important role in regulating cell energy metabolism. There are many breakthroughs in researches of facilitative GLUT in recent years. It has been known that there are 14 subtypes of facilitative GLUT with obvious tissue specificity in distribution and physiological function. Read More

View Article

Download full-text PDF

Source
April 2019
1 Read

[Advances in the roles and mechanisms of nonsense-mediated mRNA decay in embryonic development].

Sheng Li Xue Bao 2019 Apr;71(2):327-335

Institute of Neuroscience, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou 325035, China.

Nonsense-mediated mRNA decay (NMD) is originally identified as a widespread mRNA surveillance machinery in degrading 'aberrant' mRNA species with premature termination codons (PTCs) rapidly, which protects the cells from the accumulation of truncated proteins. Recent studies show that NMD can also regulate the degradation of normal gene transcripts, which execute important cellular and physiological functions. Therefore, NMD is considered as a highly conserved post-transcriptional regulatory mechanism in eukaryotes. Read More

View Article

Download full-text PDF

Source

[The role of stem cell-derived exosomes in repairing myocardial injury].

Sheng Li Xue Bao 2019 Apr;71(2):205-215

School of Pharmaceutical Sciences of Guangzhou Medical University, Guangdong Key Laboratory of Molecular Target & Clinical Pharmacology, State Key Laboratory of Respiratory Diseases Pharmacology Group, Guangzhou 511436, China.

At present, it is generally believed that the paracrine effect of stem cells in the repair of myocardial injury is one of the important ways for stem cell therapy. Exosomes are phospholipid bilayer-enclosed nanovesicles that secreted by cells under physiological and pathological conditions. Cargo loaded into exosomes including protein, lipids and nucleic acids can be delivered to recipient cells. Read More

View Article

Download full-text PDF

Source

[The biological functions of cell-to-cell connection over long distance--membrane nanotube].

Sheng Li Xue Bao 2019 Apr;71(2):196-204

Department of Cardiology and Institute of Vascular Medicine, Peking University Third Hospital; NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides; Key Laboratory of Molecular Cardiovascular Science, Ministry of Education; Beijing Key Laboratory of Cardiovascular Receptors Research, Beijing 100191, China.

Cell-to-cell connections provide conduits for signal exchanges, and play important functional roles in physiological and pathological processes of multicellular organisms. Membrane nanotubes are common long-distance connections between cells, not only transfer molecule signals and mitochondria, but also cooperate with gap junction and other cell-to-cell communications to transfer signals. During the last decade, there are many studies about membrane nanotubes, which focus on the similarities and differences between membrane nanotubes and other cell-to-cell communications, as well as their biological functions. Read More

View Article

Download full-text PDF

Source

Functional Characterization of Glucocorticoid Receptor Variants Is Required to Avoid Misinterpretation of NGS Data.

J Endocr Soc 2019 May 6;3(5):865-881. Epub 2019 Mar 6.

INSERM UMR_S U1185, Fac Med Paris Sud, Université Paris-Saclay, Le Kremlin Bicêtre, France.

Recent advances in genetic analysis technologies such as next-generation sequencing (NGS) have considerably increased the incidental discovery of genetic abnormalities. Six heterozygous missense mutations of the human glucocorticoid receptor (GR; encoded by the gene) have been identified in the context of genetic screening of endocrine pathologies. GR, a nuclear receptor, hormone-induced transcription factor, is involved in many physiological processes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/js.2019-00028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467410PMC

Interrogating metabolism as an electron flow system.

Curr Opin Syst Biol 2019 Feb;13:59-67

Bio-Electrical Engineering (BEE) Innovation Hub, University of Warwick, Coventry, CV4 7AL, UK.

Metabolism is generally considered as a neatly organised system of modular pathways, shaped by evolution under selection for optimal cellular growth. This view falls short of explaining and predicting a number of key observations about the structure and dynamics of metabolism. We highlight these limitations of a pathway-centric view on metabolism and summarise studies suggesting how these could be overcome by viewing metabolism as a thermodynamically and kinetically constrained, dynamical flow system. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.coisb.2018.10.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472609PMC
February 2019

Reflection phase microscopy using spatio-temporal coherence of light.

Optica 2018 Nov 15;5(11):1468-1473. Epub 2018 Nov 15.

Laser Biomedical Research Center, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

Many disease states are associated with cellular biomechanical changes as markers. Label-free phase microscopes are used to quantify thermally driven interface fluctuations, which allow the deduction of important cellular rheological properties. Here, the spatio-temporal coherence of light was used to implement a high-speed reflection phase microscope with superior depth selectivity and higher phase sensitivity. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1364/OPTICA.5.001468DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472928PMC
November 2018

Peer-assisted teaching method to foster learning physiological basis of electrocardiography among 1 year medical graduate students: An interventional study.

J Educ Health Promot 2019 14;8:64. Epub 2019 Mar 14.

Department of Physiology, BJGMC, Pune, Maharashtra, India.

Introduction: In peer-assisted teaching (PAT) method, students are encouraged to prepare, organize, and construct their learning program under the guidance of a teacher. The objective of the present study is to assess the benefits and outcome of PAT on students' understanding and knowledge of one of the important and difficult topics, "physiological basis of electrocardiography (ECG)."

Methods: A nonrandomized, interventional study was carried out in the department of physiology. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/jehp.jehp_313_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442245PMC
March 2019
1 Read

Optimization of fibrinogenolytic activity of subtilisin-like protease (SBTc-3) by response surface methodology.

Biotechnol Rep (Amst) 2019 Jun 1;22:e00330. Epub 2019 Apr 1.

Instituto de Investigaciones Biológicas, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Universidad Nacional de Mar del Plata, 7600 Mar del Plata, Argentina.

The aim of this study was to optimize conditions to enhance fibrinogenolytic activity of subtilisin-like protease (SBTc-3). The effects of STBc-3 concentration (0.2-5 μM), pH value (6-10) and temperature (35-50 °C) on fibrinogenolytic activity were studied through response surface methodology (RSM). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.btre.2019.e00330DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453833PMC

Cytotoxic Effects of Extract of in the Ovaries and Midgut of Latreille, 1806 (Acari: Ixodidae) Female Ticks.

J Microsc Ultrastruct 2019 Jan-Mar;7(1):28-43

Graduate Program in Chemistry, Universidade Federal do Maranhão (UFMA), Av. dos Portugueses, 1966, Bacanga, São Luís/MA, Paulínia, São Paulo, Brazil.

The present study investigated the effects of different concentrations of extract on the germinative cells and digestive processes of semi-engorged females. For this experiment, 150 ticks were divided into five groups (30 individuals each). The animals were immersed for 5 min in different concentrations of the extract, distilled water, or ethanol 50%/DMSO 1%, dried, and kept in biological oxygen demand incubator for 7 days. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/JMAU.JMAU_16_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442324PMC

Dipyridamole-Induced Left Ventricular "Rigid Body Rotation" (A Case from the Three-Dimensional Speckle Tracking Echocardiographic MAGYAR-Stress Study).

J Cardiovasc Echogr 2019 Jan-Mar;29(1):39-42

2 Department of Medicine and Cardiology Centre, Medical Faculty, Albert Szent-Györgyi Clinical Center, University of Szeged, Szeged, Hungary.

Under normal physiological conditions, the direction of systolic rotation of the left ventricular (LV) base is clockwise, and that of the LV apex is counterclockwise resulting in the wringing motion of the LV around its long axis called as LV twist. The present study was designed to present a patient with significant coronary artery disease in whom near absence of LV twist called as LV rigid body rotation could be induced during dipyridamole stress as assessed noninvasively by three-dimensional speckle-tracking echocardiography. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/jcecho.jcecho_9_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450238PMC

Direct Electron Transfer of Enzymes Facilitated by Cytochromes.

Authors:
Su Ma Roland Ludwig

ChemElectroChem 2019 Feb 13;6(4):958-975. Epub 2018 Dec 13.

Biocatalysis and Biosensing Laboratory Department of Food Science and Technology BOKU - University of Natural Resources and Life Sciences Muthgasse 18 1190 Vienna Austria.

The direct electron transfer (DET) of enzymes has been utilized to develop biosensors and enzymatic biofuel cells on micro- and nanostructured electrodes. Whereas some enzymes exhibit direct electron transfer between their active-site cofactor and an electrode, other oxidoreductases depend on acquired cytochrome domains or cytochrome subunits as built-in redox mediators. The physiological function of these cytochromes is to transfer electrons between the active-site cofactor and a redox partner protein. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/celc.201801256DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472588PMC
February 2019

Thinning Can Reduce Losses in Carbon Use Efficiency and Carbon Stocks in Managed Forests Under Warmer Climate.

J Adv Model Earth Syst 2018 Oct 15;10(10):2427-2452. Epub 2018 Oct 15.

National Research Council of Italy Institute for Agriculture and Forestry Systems in the Mediterranean (CNR-ISAFOM) Rende Italy.

Forest carbon use efficiency (CUE, the ratio of net to gross primary productivity) represents the fraction of photosynthesis that is not used for plant respiration. Although important, it is often neglected in climate change impact analyses. Here we assess the potential impact of thinning on projected carbon cycle dynamics and implications for forest CUE and its components (i. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1029/2018MS001275DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472666PMC
October 2018

Amyloid Peptide 1-42 Induces Integrin IIb3 Activation, Platelet Adhesion, and Thrombus Formation in a NADPH Oxidase-Dependent Manner.

Oxid Med Cell Longev 2019 14;2019:1050476. Epub 2019 Mar 14.

Institute of Biomedical and Clinical Sciences, University of Exeter Medical School, UK.

The progression of Alzheimer's dementia is associated with neurovasculature impairment, which includes inflammation, microthromboses, and reduced cerebral blood flow. Here, we investigate the effects of amyloid peptides on the function of platelets, the cells driving haemostasis. Amyloid peptide 1-42 (A1-42), A1-40, and A25-35 were tested in static adhesion experiments, and it was found that platelets preferentially adhere to A1-42 compared to other A peptides. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2019/1050476DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441506PMC

Effects of aerobic exercise on the expressions and activities of nitric oxide synthases in the blood vessel endothelium in prediabetes mellitus.

Exp Ther Med 2019 May 26;17(5):4205-4212. Epub 2019 Mar 26.

Laboratory of Sport Physiology and Biomedicine, School of Physical Education and Sport Sciences, Fujian Normal University, Fuzhou, Fujian 350007, P.R. China.

Previous studies by our group have indicated that exercise intervention can ameliorate endothelial dysfunction, which is an early pathophysiological change of prediabetes mellitus. The present study aimed to test the hypothesis that nitric oxide synthases (NOSs), which are expressed in blood vessel endothelium, contribute to the mitigation of vascular endothelium-dependent dysfunction by aerobic exercise in prediabetes mellitus. A prediabetic rat model was established by feeding the rats an additional high-energy diet, and was confirmed by testing blood glucose levels, the area-under-the-curve for the blood glucose tests (P<0. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3892/etm.2019.7437DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468937PMC

Traditional plant functional groups explain variation in economic but not size-related traits across the tundra biome.

Glob Ecol Biogeogr 2019 Jan 16;28(2):78-95. Epub 2018 Nov 16.

Environmental Biology, Department Institute of Environmental Sciences, CML, Leiden University Leiden The Netherlands.

Aim: Plant functional groups are widely used in community ecology and earth system modelling to describe trait variation within and across plant communities. However, this approach rests on the assumption that functional groups explain a large proportion of trait variation among species. We test whether four commonly used plant functional groups represent variation in six ecologically important plant traits. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/geb.12783DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472633PMC
January 2019

Anti-Atopic Dermatitis Effect of Extract via Inhibiting the STAT1 Pathway.

Mediators Inflamm 2019 17;2019:3760934. Epub 2019 Mar 17.

Department of Pharmacology, College of Korean Medicine, Sangji University, Wonju-si, Gangwon-do 26339, Republic of Korea.

(SF) is a green alga rich in chlorophyll with unique flavor and taste. It is also called Maesaengi which has antioxidant and other physiological activities. In the present study, we evaluated the therapeutic effects of SF in a mouse model of body-induced atopic dermatitis (AD) and in tumor necrosis factor- and interferon--stimulated HaCaT keratinocytes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2019/3760934DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441517PMC

Risk-Adjusted Analysis of Patients Undergoing Emergency Laparotomy Using POSSUM and P-POSSUM Score: A Prospective Study.

Niger J Surg 2019 Jan-Jun;25(1):45-51

Department of General Surgery, J.L.N Medical College, Ajmer, Rajasthan, India.

Background: Comparison of operative morbidity rates after emergency laparotomy between units may be misleading because it does not take into account the physiological variables of patients' conditions. Surgical risk scores have been created, and the most commonly used is the Physiological and Operative Severity Score for the enumeration of Mortality (POSSUM) or one of its modifications, the Portsmouth-POSSUM (P-POSSUM), usually requires intraoperative information.

Objective: The objective of this study is to evaluate the POSSUM and P-POSSUM scores in predicting postoperative morbidity and mortality in patients undergoing emergency laparotomy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/njs.NJS_11_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452761PMC

Role of Oxidative Stress in Male Infertility: An Updated Review.

Authors:
Ahmed T Alahmar

J Hum Reprod Sci 2019 Jan-Mar;12(1):4-18

Department of Pathological Analysis, College of Science, University of Sumer, Thi-Qar, Iraq.

Current evidence links oxidative stress (OS) to male infertility, reduced sperm motility, sperm DNA damage and increased risk of recurrent abortions and genetic diseases. A review of PubMed, Medline, Google Scholar, and Cochrane review databases of published articles from years 2000-2018 was performed focusing on physiological and pathological consequences of reactive oxygen species (ROS), sperm DNA damage, OS tests, and the association between OS and male infertility, pregnancy and assisted reproductive techniques outcomes. Generation of ROS is essential for reproductive function, but OS is detrimental to fertility, pregnancy, and genetic status of the newborns. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/jhrs.JHRS_150_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472207PMC

Fractional Amplitude of Low-Frequency Fluctuations and Functional Connectivity in Comatose Patients Subjected to Resting-State Functional Magnetic Resonance Imaging.

Ann Indian Acad Neurol 2019 Apr-Jun;22(2):203-209

Department of Radiology, Changsha Central Hospital, Changsha, China.

Objective: The objective of the study is to investigate the changes of fractional amplitude of low-frequency fluctuations (fALFFs) and functional connectivity (FC) in the brain function of comatose patients with resting-state blood-oxygenation-level-dependent functional magnetic resonance imaging (BOLD-fMRI) and to discuss the underlying neurophysiological mechanism of disease.

Materials And Methods: Resting-state BOLD-fMRI scans were conducted on 20 comatose patients and 20 age-matched and gender-matched controls. The differences of fALFF between two groups were analyzed with two-sample -test; significant differences of connectivity between groups were acquired to calculate the FC of the precuneus with other brain regions. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/aian.AIAN_420_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472252PMC
  • Page 1 of 15194