413,082 results match your criteria Physicians Practice [Journal]


Comment les médecins généralistes favorisent-ils l?équité d?accès à l?éducation thérapeutique pour leurs patients.

Sante Publique 2018 Sep;S2(HS2):69-80

Our research is designed to understand how and under what conditions general practitioners contribute to equitable access to patient education (PE).We conducted a survey based on interactionist sociology in a sample of 32 doctors. These practitioners worked in the context of health networks and health care centres and were also involved in the PE resource centre for the Île-de-France region, thereby providing a favourable setting for our study, also reflected by the fact that one-half of practitioners were aware of the importance of or had been trained in PE. Read More

View Article
September 2018
1 Read

Understanding Patient Preferences and Unmet Needs in Non-alcoholic Steatohepatitis (NASH): Insights from a Qualitative Online Bulletin Board Study.

Adv Ther 2018 Dec 13. Epub 2018 Dec 13.

Novartis Healthcare Pvt Ltd, Hyderabad, India.

Introduction: The aim of this work was to understand how patients with non-alcoholic steatohepatitis (NASH) perceive their disease, unmet needs, and expectations regarding future treatment through online bulletin board (OBB) qualitative research.

Methods: OBB is an asynchronous online qualitative market research tool that provides an open forum for interactive discussion among participants. Patients with NASH were recruited via physician referral and completed a screener questionnaire to ensure their eligibility and willingness to participate. Read More

View Article
December 2018

ABO Blood Type and Hematoma Expansion After Intracerebral Hemorrhage: An Exploratory Analysis.

Neurocrit Care 2018 Dec 13. Epub 2018 Dec 13.

Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.

Background/purpose: Blood type has become an increasingly recognized risk factor for coagulopathy. We explored the association between blood type and hematoma expansion (HE) after intracerebral hemorrhage (ICH).

Methods: Spontaneous ICH patients prospectively enrolled in an ongoing ICH cohort study at Columbia University Irving Medical Center from 2009 to 2016 were evaluated. Read More

View Article
December 2018
1 Read

Predictors of thrombosis in testicular cancer during platinum-based chemotherapy.

World J Urol 2018 Dec 13. Epub 2018 Dec 13.

Department of Urology, Uro-Oncology, Robot Assisted and Reconstructive Urologic Surgery, University Hospital Cologne, Kerpener Straße 62, 50937, Cologne, Germany.

Purpose: To identify potential risk factors for the development of venous thromboembolic events in testicular cancer patients receiving platinum-based chemotherapy.

Methods: We performed a retrospective analysis including 255 patients with testicular germ cell tumors who received platinum-based chemotherapy from 2003 to 2018 as a multi-center observational cohort study. Patient and tumor characteristics of patients with and without a thromboembolic event were analyzed. Read More

View Article
December 2018

Impact of Daily Electronic Laboratory Alerting on Early Detection and Clinical Documentation of Acute Kidney Injury in Hospital Settings.

Acad Pathol 2018 Jan-Dec;5:2374289518816502. Epub 2018 Dec 4.

Department of Pathology and Laboratory Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY, USA.

Acute kidney injury, especially early-stage disease, is a common hospital comorbidity requiring timely recognition and treatment. We investigated the effect of daily laboratory alerting of patients at risk for acute kidney injury as measured by documented diagnoses. A quasi-experimental study was conducted at 8 New York hospitals between January 1, 2014, and June 30, 2017. Read More

View Article
December 2018

The Life and Work of Nikolai Ivanovich Pirogov (1810-1881): An Outstanding Anatomist and Surgeon.

Cureus 2018 Oct 8;10(10):e3424. Epub 2018 Oct 8.

Otolaryngology, Aristotle University of Thessaloniki, Thessalonki, GRC.

Nikolai Ivanovich Pirogov is considered one of the most important anatomists and surgeons in the history of medicine. The Russian physician conducted more than 11,000 dissections and meticulously studied human anatomy, discovering important anatomical regions such as Pirogov's triangle. Pirogov developed surgical methods and techniques used by physicians for many decades such as Pirogov's amputation. Read More

View Article
October 2018

Implementing a Standardized Nurse-driven Rounding Protocol in a Trauma-surgical Intensive Care Unit: A Single Institution Experience.

Cureus 2018 Oct 8;10(10):e3422. Epub 2018 Oct 8.

Surgery, Stanford Hospital, Stanford, USA.

Introduction Patient care in the trauma-surgical intensive care unit (SICU) requires trust and effective communication between nurses and physicians. Our SICU suffered from poor communication and trust between nurses and physicians, negatively impacting the working environment and, potentially, patient care. Methods A SICU Task Force studied communication practices and identified areas for improvement, leading to several interventions. Read More

View Article
October 2018

An AI-Based Heart Failure Treatment Adviser System.

IEEE J Transl Eng Health Med 2018 23;6:2800810. Epub 2018 Nov 23.

Computer Science DepartmentThe University of Texas at DallasRichardsonTX75080USA.

Management of heart failure is a major health care challenge. Healthcare providers are expected to use best practices described in clinical practice guidelines, which typically consist of a long series of complex rules. For heart failure management, the relevant guidelines are nearly 80 pages long. Read More

View Article
November 2018

Miliary lung metastases from non-small cell lung cancer with Exon 20 insertion: A dismal prognostic entity: A case report.

Mol Clin Oncol 2018 Dec 1;9(6):673-676. Epub 2018 Oct 1.

Department of Respiratory Medicine, Kanagawa Cardiovascular and Respiratory Center, Yokohama, Kanagawa 236-0051, Japan.

Miliary lung metastases have been reported to be frequently observed in nοn-small cell lung cancer (NSCLC) with major EGFR mutations, which consist of exon 19 deletion and exon 21 L858R. However, it remains undetermined whether NSCLC with minor EGFR mutations possesses characteristics similar to those with major EGFR mutations. In the present study, two cases of miliary lung metastases from NSCLC with exon 20 insertion were reported. Read More

View Article
December 2018

The application of updating PIM-Taiwan criteria in clinic-visiting older patients with polypharmacy.

Ther Adv Drug Saf 2018 Dec 15;9(12):699-709. Epub 2018 Oct 15.

Department of Geriatrics and Gerontology, National Taiwan University Hospital, Zhongshan South Road, Zhongzheng District, Taipei, 100, Taiwan.

Background: PIM-Taiwan criteria were first established in 2010 for potentially inappropriate medications (PIMs). Currently, updating of PIM criteria is mandatory because of newly established evidence and newly developed medications. This study aims to evaluate the prevalence of PIM based on country-specific PIM criteria and factors associated with PIM use by applying 2010 version and newly updating PIM-Taiwan criteria in a cohort with polypharmacy. Read More

View Article
December 2018

Experiences with the standardized classification of surgical complications (Clavien-Dindo) in general surgery patients.

Eur Surg 2018 24;50(6):256-261. Epub 2018 Jul 24.

Division of General Surgery, Department of Surgery, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria.

Background: The standardized Clavien-Dindo classification of surgical complications is applied as a simple and widely used tool to assess and report postoperative complications in general surgery. However, most documentation uses this classification to report surgery-related morbidity and mortality in a single field of surgery or even particular intervention. The aim of the present study was to present experiences with the Clavien-Dindo classification when applied to all patients on the general surgery ward of a tertiary referral care center. Read More

View Article

Increased Risk of Metabolic Syndrome in Antidepressants Users: A Mini Review.

Front Psychiatry 2018 28;9:621. Epub 2018 Nov 28.

Psychiatry Ward, University Hospital Maggiore della Carità, Novara, Italy.

Mounting evidence has shown that the risk of metabolic syndrome (MetS) is substantially overlapping in the diagnostic subgroups of psychiatric disorders. While it is widely acknowledged that patients receiving antipsychotic medications are at higher risk of MetS than antipsychotic-naive ones, the association between antidepressants and MetS is still debated. The goal of our mini review was to analyse the relationship among depressive symptoms, antidepressant use and the occurrence of MetS. Read More

View Article
November 2018

Adverse Drug Reaction Onsets in Uganda's VigiBase: Delayed International Visibility, Data Quality and Illustrative Signal Detection Analyses.

Pharmaceut Med 2018 17;32(6):413-427. Epub 2018 Nov 17.

3MRC Biostatistics Unit, University of Cambridge, Cambridge, UK.

Introduction: Developing countries can improve their pharmacovigilance systems by analysing their own medication safety data.

Objective: The aims of this study were to characterize Uganda's reported adverse drug reaction (ADR) onsets in 2012-2015 that were registered on VigiBase by 31 December 2017, to document delays in international visibility and the influence of covariates on this delay from ADR onsets in 2013 + 2014, to examine data quality, and to illustrate analytical approaches for safety data, particularly for patients receiving antiretroviral therapy (ART).

Methods: International delay was defined as elapsed time from complete ADR onset date to entry date on VigiBase, with covariates examined using Cox proportional hazards regression. Read More

View Article
November 2018
1 Read

Physician-pharmacist collaborative practice and telehealth may transform hypertension management.

J Hum Hypertens 2018 Dec 13. Epub 2018 Dec 13.

Clinical Research Unit, Italian Institute of Telemedicine, Varese, Italy.

Community pharmacists play a crucial role in hypertension management and their intervention, mainly including education, medication monitoring, and reviewing, blood pressure (BP) measurement and cardiovascular risk factors tracking, have proved to enhance BP control and adherence to antihypertensive treatment. A multidisciplinary collaborative approach with the referring physician and a patient-centered model of care have been proved to be particularly effective for improving control of hypertension and promoting patients' health. The inclusion of telehealth in such model (the so-called telepharmacy) may expand the reach of the pharmacist's intervention and provide pharmacy operations and patient care at a distance with further benefits for hypertensive patients and their managing physicians. Read More

View Article
December 2018

Pulmonary hypertension in chronic lung disease and hypoxia.

Eur Respir J 2018 Dec 13. Epub 2018 Dec 13.

University of Giessen and Marburg Lung Center (UGMLC), Justus-Liebig University Giessen and Member of the German Center for Lung Research (DZL), Giessen, Germany.

Pulmonary hypertension (PH) frequently complicates the course of patients with various forms of chronic lung disease (CLD). CLD-associated PH (CLD-PH) is invariably associated with reduced functional ability, impaired quality of life, greater oxygen requirements and an increased risk of mortality. The aetiology of CLD-PH is complex and multifactorial, with differences in the pathogenic sequelae between the diverse forms of CLD. Read More

View Article
December 2018

CD150high CD4 T cells and CD150high Tregs regulate hematopoietic stem cell quiescence via CD73.

Haematologica 2018 Dec 13. Epub 2018 Dec 13.

Columbia University College of Physicians and Surgeons;

Various extrinsic signals tightly control hematopoietic stem cell quiescence. Our recent study showed that hematopoietic stem cells are regulated by a special FoxP3+ regulatory T cell population with high expression of a hematopoietic stem cell marker, CD150. Extracellular adenosine generated via a cell-surface ectoenzyme CD39 on CD150high regulatory T cells maintained HSC quiescence. Read More

View Article
December 2018

Easier and Faster Is Not Always Better: Grounded Theory of the Impact of Large-Scale System Transformation on the Clinical Work of Emergency Medicine Nurses and Physicians.

JMIR Hum Factors 2018 Dec 13;5(4):e11013. Epub 2018 Dec 13.

Pathology & Laboratory Medicine, Schulich School of Medicine & Dentistry, University of Western Ontario, London, ON, Canada.

Background: The effectiveness of Lean Thinking as a quality improvement method for health care has been contested due, in part, to our limited contextual understanding of how it affects the working conditions and clinical workflow of nurses and physicians. Although there are some initial indications, arising from prevalence surveys and interviews, that Lean may intensify work performed within medical environments, the evidence base still requires detailed descriptions of the changes that were actually introduced to individuals' clinical workflow and how these changes impacted health care professionals.

Objective: The aim of this study was to explore ways in which a Lean intervention may impact the clinical work of emergency medicine nurses and physicians. Read More

View Article
December 2018
1 Read

Radiologist Adoption of Interactive Multimedia Reporting Technology.

J Am Coll Radiol 2018 Dec 11. Epub 2018 Dec 11.

Department of Radiology and Medical Imaging, University of Virginia, Charlottesville, VA. Electronic address:

Purpose: To determine if radiologists find enough value in available interactive multimedia reporting technology to routinely adopt it into clinical practice.

Materials And Methods: Our institution's reporting application (Vue Reporting, Carestream Health) allows the incorporation of multimedia elements, including active hyperlinks, into clinical reports, but would radiologists find enough value in this technique to change their practice? We retrospectively reviewed 559,841 diagnostic reports issued July 2016 to February 2018 for the presence of text hyperlinks that interactively connect to imaging findings in the PACS. Results were subdivided by modality, reporting radiologist role (ie, resident, fellow, attending physician), and subspecialty. Read More

View Article
December 2018

Access to Interventional Radiology Services in Small Hospitals and Rural Communities: An ACR Membership Intercommission Survey.

J Am Coll Radiol 2018 Dec 11. Epub 2018 Dec 11.

Department of Interventional Radiology, Mayo Clinic, Jacksonville, Florida.

Purpose: To evaluate the status of interventional radiology (IR) staffing, recruitment, and retention in the United States, specifically as they apply to small hospitals and rural communities.

Materials And Methods: A 22-question survey was created by an ACR intercommission workgroup and circulated via e-mail to ACR members who self-identified as a "group practice leader," "general radiologist," "interventional radiologist," or "abdominal radiologist." Contingency tables were constructed, and bivariate analyses were performed to assess overall responses and the distribution of responses among specific groups of respondents. Read More

View Article
December 2018

Increasing Diversity in Clinical Trials: Overcoming Critical Barriers.

Curr Probl Cardiol 2018 Nov 9. Epub 2018 Nov 9.

Clinical trial results provide the critical evidence base for evaluating the safety and efficacy of new medicines and medical products. Efficacy and safety may differ among population subgroups depending on intrinsic/extrinsic factors, including sex, age, race, ethnicity, lifestyle, and genetic background. Racial and ethnic minorities continue to be underrepresented in cardiovascular and other clinical trials. Read More

View Article
November 2018

Neuraxial labor analgesia, obstetrical outcomes, and the Robson 10-Group Classification.

Int J Obstet Anesth 2018 Nov 27. Epub 2018 Nov 27.

Department of Anesthesiology and Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Columbia University College of Physicians and Surgeons, New York, USA.

View Article
November 2018

Work hours of employed obstetricians in Taiwan.

Taiwan J Obstet Gynecol 2018 Dec;57(6):801-805

Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan; Department of Obstetrics and Gynecology, Lee Women's Hospital, Taichung, Taiwan; Department of Obstetrics and Gynecology, Chung Shan Medical University Hospital, Taichung, Taiwan. Electronic address:

Objective: Obstetricians have longer work hours and work hour restriction of employed physicians will be implemented thereafter. This study was to survey the impact of work hour restriction and determine the weekly work hours of obstetricians.

Materials And Methods: Since December 1, 2017, to January 31, 2018, a questionnaire about reasonable workload investigation, impact of work hour restriction and weekly work diary was mailed to 196 employed obstetricians who delivered more than 20 newborns per months. Read More

View Article
December 2018

Interventional Oncology: Keeping Out of Trouble in Ablation Techniques.

Tech Vasc Interv Radiol 2018 Dec 14;21(4):223-227. Epub 2018 Aug 14.

Department of Interventional Radiology, New York Presbyterian Hospital/Weill Cornell Medicine, New York, NY. Electronic address:

Interventional radiologists provide an essential role in the therapy and management of cancer patients. Computed-tomography (CT) guided percutaneous procedures have enabled interventionalists to treat multiple solid organ malignancies with minimal risk, however, certain lesions may present challenges to physicians due to a difficult approach, or their close proximity to other vital structures. The following presents a brief summary of tips and tricks the interventionalist may use to provide their patients with safe and effective therapy. Read More

View Article
December 2018

Impact on medical practice of accessing pharmaceutical records.

Int J Med Inform 2019 Jan 12;121:58-63. Epub 2018 Sep 12.

Department of Biostatistics, Rouen University Hospital, 1 rue de Germont, 76031 Rouen, France; Normandie Univ., UNIROUEN, INSERM U 1219, F76031 Rouen, France.

Introduction: The pharmaceutical record system (PRS) is a French nationwide centralized electronic database shared among all community pharmacists listing all drugs dispensed by community pharmacists in the last four months. The objective of this study, the Medication Assessment Through Real time Information eXchange - Distributed Pharmaceutical Record System (MATRIX - DPRS) study, was to assess the clinical impact of the PRS upon granting access to physicians in three hospital specialties: anesthesiology, emergency medicine and geriatrics.

Material And Methods: A multicenter prospective study was conducted in six hospital departments, two per specialty. Read More

View Article
January 2019

Web System Prototype based on speech recognition to construct medical reports in Brazilian Portuguese.

Int J Med Inform 2019 Jan 26;121:39-52. Epub 2018 Oct 26.

Laboratory of Bioinformatics, Western Paraná State University, Presidente Tancredo Neves Avenue, 6731, ZIP code 85867-900, Foz do Iguaçu, Brazil; Service of Coloproctology, Faculty of Medical Sciences, University of Campinas, Tessália Vieira de Camargo Street, 126, ZIP code 13083-887, Campinas, Brazil. Electronic address:

The overall purpose of automatic speech recognition systems is to make possible the interaction between humans and electronic devices through speech. For example, the content captured from user's speech using a microphone can be transcribed into text. In general, such systems should be able to overcome adversities such as noise, communication channel variability, speaker's age and accent, speech speed, concurrent speeches from other speakers and spontaneous speech. Read More

View Article
January 2019

Increased Use of Medical Marijuana: Skepticism vs. Evidence.

Authors:
Jeannette Y Wick

Consult Pharm 2018 Dec;33(12):680-689

The use of medical marijuana-both the psychoactive tetrahydrocannabinol and its nonpsychoactive relative cannabidiol-is a growing practice in facilities served by senior care pharmacists. Currently, 30 states have approved its use under a variety of different regulations and for a number of conditions. Its use is bolstered by a growing number of Americans who support legalization of cannabis. Read More

View Article
December 2018

Identifying MSM-competent physicians in China: a national online cross-sectional survey among physicians who see male HIV/STI patients.

BMC Health Serv Res 2018 Dec 13;18(1):964. Epub 2018 Dec 13.

Shenzhen Nanshan Center for Chronic Disease Control, Shenzhen, China.

Background: Men who have sex with men (MSM) are at high risk of human immunodeficiency virus (HIV) infection and sexually transmitted infection (STI) in China. Inadequate clinical services and poor clinical competency among physicians are major barriers to improving the sexual health of MSM. This study aims to understand physician clinical competency in providing MSM health services in China. Read More

View Article
December 2018

Public knowledge of emergency medicine in Beirut, Lebanon.

BMC Emerg Med 2018 Dec 13;18(1):55. Epub 2018 Dec 13.

Department of Internal Medicine, Clinical Research Institute, Residency Research Program, Faculty of Medicine, American University of Beirut Medical Center, Beirut, Lebanon.

Introduction: To examine the public's level of knowledge and expectations of Emergency Medicine (EM) in Beirut, Lebanon.

Methods: A nested cross-sectional study was conducted exploring participants' knowledge and expectations of EM; the skillset, role and scope of practice of the emergency physician, and the dynamics of the Emergency Department (ED).

Results: A majority understand EM physicians perform minor procedures (83%), have specialized training (79%) and that they should be treated by a specialized EM physician (74%). Read More

View Article
December 2018

[Possibilities of doctor-patient communication - understanding patients' expectations].

Orv Hetil 2018 Dec;159(50):2136-2143

Népegészségtani Intézet, Szegedi Tudományegyetem, Általános Orvostudományi Kar Szeged, Dóm tér 10., 6720.

Introduction: Nowadays doctor-patient consultation is not limited to personal appointments, there are new technical possibilities to keep contact.

Aim: The aim of our study was to examine the way in which the doctor and patient interact with each other between two personal consultations and how the patients would like to reach their physicians when needed.

Method: Questionnaire survey was done among waiting patients in an outpatient clinic in Budapest. Read More

View Article
December 2018

Association between Atmospheric Particulate Pollutants and Mortality for Cardio-Cerebrovascular Diseases in Chinese Korean Population: A Case-Crossover Study.

Int J Environ Res Public Health 2018 Dec 12;15(12). Epub 2018 Dec 12.

School of Public Health, Medical College of Qingdao University, Qingdao 266021, Shandong Province, China.

Background: Air pollution in large Chinese cities has led to recent studies that highlighted the relationship between particulate matters (PM) and elevated risk of cardio-cerebrovascular mortality. However, it is unclear as to whether: (1) The same adverse relations exist in cities with relatively low levels of air pollution; and (2) the relationship between the two are similar across ethnic groups.

Methods: We collected data of PM (PM with an aerodynamic diameter ≤ 2. Read More

View Article
December 2018

United States Physician Preferences Regarding Healthcare Financing Options: A Multistate Survey.

Pharmacy (Basel) 2018 Dec 9;6(4). Epub 2018 Dec 9.

College of Business, Western New England University, 1215 Wilbraham Road, Springfield, MA 01119, USA.

Not much is currently known about United States (US) physicians' opinions about healthcare financing, specifically subsequent to the creation and implementation of the Affordable Care Act (ACA). A four state survey of practicing US based physicians' opinions about healthcare financing following ACA passage and implementation. Physician leaders practicing in the state of New York, Texas, Colorado and Mississippi were surveyed. Read More

View Article
December 2018

Future Implications of Using Registered Dietitians in Multidisciplinary Polycystic Ovary Syndrome Treatment.

Healthcare (Basel) 2018 Dec 8;6(4). Epub 2018 Dec 8.

Department of Human Nutrition and Foods, West Virginia University, Morgantown, WV 26506, USA.

Polycystic ovary syndrome (PCOS) is the most common reproductive endocrine disorder in females with insulin resistance playing a key role in pathogenesis. The objective of this study was to investigate current trends and future implications of multidisciplinary PCOS clinics with inclusion of dietitians. A two-phase, formative investigation on practitioners was conducted through an anonymous survey followed by focus groups. Read More

View Article
December 2018

Retrospective Review of Limitations of Care for Inpatients at a Free-Standing, Tertiary Care Children's Hospital.

Children (Basel) 2018 Dec 10;5(12). Epub 2018 Dec 10.

Division of Pediatric Critical Care, Nemours/Alfred I. duPont Hospital for Children, Wilmington, DE 19899, USA.

Limited studies exist regarding the timing, location, or physicians involved in do-not-resuscitate (DNR) order placement in pediatrics. Prior pediatric studies have noted great variations in practice during end-of-life (EOL) care. This study aims to analyze the timing, location, physician specialties, and demographic factors influencing EOL care in pediatrics. Read More

View Article
December 2018

Treatment of Pain in Cancer: Towards Personalised Medicine.

Cancers (Basel) 2018 Dec 10;10(12). Epub 2018 Dec 10.

Department of Anesthesiology and Pain Management, Maastricht University Medical Centre (MUMC+), University Pain Centre Maastricht (UPCM), 6229HX Maastricht, The Netherlands.

Despite increased attention to cancer pain, pain prevalence in patients with cancer has not improved over the last decade and one third of cancer patients on anticancer therapy and half of patients with advanced disease still suffer from moderate to severe pain. In this review, we explore the possible reasons for the ongoing high prevalence of cancer pain and discuss possible future directions for improvement in personalised pain management. Among possible reasons for the lack of improvement are: Barriers for patients to discuss pain with clinicians spontaneously; pain measurement instruments are not routinely used in daily practice; limited knowledge concerning the assessment of undertreatment; changes in patients' characteristics, including the ageing of the population; lack of significant improvement in the treatment of neuropathic pain; limitations of pharmacological treatment and lack of evidence-based nonpharmacological treatment strategies. Read More

View Article
December 2018

Kampo (Traditional Japanese Herbal) Formulae for Treatment of Stomatitis and Oral Mucositis.

Medicines (Basel) 2018 Dec 10;5(4). Epub 2018 Dec 10.

Department of physiology, School of medicine, Showa University, Tokyo 142-8555, Japan.

Stomatitis is occasionally multiple, recurrent, and refractory. Currently, mucositis induced by chemotherapy and radiation therapy in patients with cancer has become a significant clinical problem. Effective treatments have not been established and the treatment of numerous cases remains a challenge for physicians. Read More

View Article
December 2018
1 Read

Associations between DNAH1 gene polymorphisms and male infertility: A retrospective study.

Medicine (Baltimore) 2018 Dec;97(49):e13493

Center for Reproductive Medicine.

Genetic abnormalities could account for 10% to 15% of male infertility cases, so increasing attention is being paid to gene mutations in this context. DNAH1 gene polymorphisms are highly correlated with astheno-teratozoospermia, but limited information has been reported on pathogenic variations in DNAH1 in the Chinese population. We explored 4 novel variations of the DNAH1 gene in Chinese infertile patients. Read More

View Article
December 2018

Arterial involvement in Erdheim-Chester disease: A retrospective cohort study.

Medicine (Baltimore) 2018 Dec;97(49):e13452

Division of Rheumatology.

Erdheim-Chester disease (ECD) is a rare histiocytosis of the "L" (Langerhans) group with multisystem involvement that can affect the large and medium-sized arteries mimicking vasculitis. Aortic involvement is common but the frequency and outcome of aortic branch vessel abnormalities are less well described.Patients with ECD were retrospectively identified. Read More

View Article
December 2018

Clinical massage therapy for patients with cancer-related fatigue protocol of a systematic review.

Medicine (Baltimore) 2018 Dec;97(49):e13440

Dongfang Hospital of Beijing University of Chinese Medicine.

Background: Cancer-related fatigue (CRF) is a prevalent and debilitating symptom experienced by cancer survivors, one that severely compromises functional independence and quality of life. Clinical massage therapy (CMT), as an important part of complementary and alternative medicine, is widely employed among massage therapists, physical therapists, nurses, and physicians when managing CRF. Clinical research indicates that CMT produced relief of CRF. Read More

View Article
December 2018

Ictal networks of temporal lobe epilepsy: views from high-frequency oscillations in stereoelectroencephalography.

Authors:

J Neurosurg 2018 Nov 1:1-9. Epub 2018 Nov 1.

OBJECTIVEIn this study, the authors investigated high-frequency oscillation (HFO) networks during seizures in order to determine how HFOs spread from the focal cerebral cortex and become synchronized across various areas of the brain.METHODSAll data were obtained from stereoelectroencephalography (SEEG) signals in patients with drug-resistant temporal lobe epilepsy (TLE). The authors calculated intercontact cross-coefficients between all pairs of contacts to construct HFO networks in 20 seizures that occurred in 5 patients. Read More

View Article
November 2018

The impact of the reserve military neurosurgeon: practice, community, and service.

Authors:

Neurosurg Focus 2018 Dec;45(6):E14

OBJECTIVEPapers from 2002 to 2017 have highlighted consistent unique socioeconomic challenges and opportunities facing military neurosurgeons. Here, the authors focus on the reserve military neurosurgeon who carries the dual mission of both civilian and military responsibilities.METHODSSurvey solicitation of current active duty and reserve military neurosurgeons was performed in conjunction with the AANS/CNS Joint Committee of Military Neurosurgeons and the Council of State Neurosurgical Societies. Read More

View Article
December 2018

The 2018 AANS Presidential Address. The privilege of service.

Authors:

J Neurosurg 2018 Dec;129(6):1377-1383

The theme of the 2018 American Association of Neurological Surgeons Annual Meeting was "The Privilege of Service." In the current climate of rapid change in healthcare delivery and increasing pressure on physicians, this theme was chosen to remind us of our true priorities and of the amazing opportunities that we have as neurosurgeons. In parallel to the classic triple-threat practitioner who excels in teaching, research, and clinical care, future neurosurgeons will need to acquire mastery in three areas of service, which have been summarized as the three A's: administration, advocacy, and altruism. Read More

View Article
December 2018

Integration of rotational angiography enables better dose planning in Gamma Knife radiosurgery for brain arteriovenous malformations.

Authors:

J Neurosurg 2018 Dec;129(Suppl1):17-25

OBJECTIVEIn Gamma Knife radiosurgery (GKS) for arteriovenous malformations (AVMs), CT angiography (CTA), MRI, and digital subtraction angiography (DSA) are generally used to define the nidus. Although the AVM angioarchitecture can be visualized with superior resolution using rotational angiography (RA), the efficacy of integrating RA into the GKS treatment planning process has not been elucidated.METHODSUsing data collected from 25 consecutive patients with AVMs who were treated with GKS at the authors' institution, two neurosurgeons independently created treatment plans for each patient before and after RA integration. Read More

View Article
December 2018

Nintedanib in Idiopathic Pulmonary Fibrosis: Practical Management Recommendations for Potential Adverse Events.

Respiration 2018 Dec 13:1-12. Epub 2018 Dec 13.

Department of Pulmonary Disease, Erasmus Medical Centre, University Hospital Rotterdam, Rotterdam, The Netherlands.

Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease with a dismal survival rate of only 3 years and no curative pharmacological therapy. The recent approval of 2 anti-fibrotic drugs (nintedanib and pirfenidone) that slow disease progression has provided some hope for patients. However, effectively managing anti-fibrotic treatment can be a challenge due to tolerability issues, the presence of pulmonary and extra-pulmonary comorbidities, and the need for concomitant medications in many patients. Read More

View Article
December 2018

Catheter Tract Metastasis in Mesothelioma Patients with Indwelling Pleural Catheters: A Retrospective Cohort Study.

Respiration 2018 Dec 13:1-8. Epub 2018 Dec 13.

Division of Respirology, Department of Medicine, University of Ottawa, Ottawa, Ontario,

Background: Use of indwelling pleural catheters (IPCs) for the management of symptomatic pleural effusions in patients with mesothelioma has increased in popularity. An important concern with this approach is the potential for the development of catheter tract metastasis (CTM).

Objectives: To determine the incidence of IPC-related CTM in patients with malignant pleural mesothelioma (MPM). Read More

View Article
December 2018

Physicochemical parameters of NO-containing gas flow affect wound healing therapy. An experimental study.

Eur J Pharm Sci 2018 Dec 10. Epub 2018 Dec 10.

I.M. Sechenov First Moscow State Medical University, Moscow, Russia; N.N. Semenov Institute of Chemical Physics, Moscow, Russia. Electronic address:

Therapy of wounds and inflammatory diseases with NO-containing gas flows (NO-CGF) has proved to be effective in a longterm clinical practice. Plasma-chemical generation of nitric oxide occurs from atmospheric air in Plason device. For the purpose of modification and improvement of NO-therapy, effects of various physicochemical parameters of the NO-CGF on inflammatory and reparative processes in wounds were studied. Read More

View Article
December 2018

Practice Patterns for Older Adult Patients With Advanced Cancer: Physician Office Versus Hospital Outpatient Setting.

J Oncol Pract 2018 Dec 13:JOP1800315. Epub 2018 Dec 13.

Memorial Sloan Kettering Cancer Center, New York, NY.

Purpose:: A shift in outpatient oncology care from the physician's office to hospital outpatient settings has generated interest in the effect of practice setting on outcomes. Our objective was to examine whether medical oncologists' prescribing of drugs and services for older adult patients with advanced cancer is used more in physicians' offices compared with hospital outpatient departments.

Methods:: This was a retrospective comparative study. Read More

View Article
December 2018

Advance Care Planning Among Patients With Advanced Cancer.

J Oncol Pract 2018 Dec 13:JOP1800044. Epub 2018 Dec 13.

The Pennsylvania State University, College of Medicine, Hershey, PA.

Purpose:: Advance directives (AD) have been heralded as vehicles to promote patient autonomy and have been decried as ineffective. Efforts to improve advance care planning (ACP) and AD documents are wide ranging but have not been prospectively studied.

Materials And Methods:: In an institutional review board-approved, single-blind, randomized, controlled trial, we compared an interactive, educational ACP decision aid to standard ACP among patients with advanced cancer. Read More

View Article
December 2018

Acceptable medication non-adherence: A crowdsourcing study among French physicians for commonly prescribed medications.

PLoS One 2018 13;13(12):e0209023. Epub 2018 Dec 13.

METHODS Team, Centre of Research in Epidemiology and Statistics Sorbonne Paris Cité (CRESS), INSERM, UMR 1153, Paris, France.

Background: Achieving good medication adherence is a major challenge for patients with chronic conditions. Our study aimed to assess the Threshold for Unacceptable Risk of Non-adherence (TURN), defined as the threshold at which physicians consider the health risks incurred by patients due to medication non-adherence unacceptable, for the most commonly prescribed drugs in France.

Methods: We conducted an online study using a crowdsourcing approach among French general practitioners and specialists from September 2016 to August 2017. Read More

View Article
December 2018

Unresolved Splenomegaly in Recently Resettled Congolese Refugees - Multiple States, 2015-2018.

MMWR Morb Mortal Wkly Rep 2018 12 14;67(49):1358-1362. Epub 2018 Dec 14.

In 2014, panel physicians from the International Organization for Migration (IOM), who conduct Department of State-required predeparture examinations for U.S.-bound refugees at resettlement sites in Uganda, noticed an unusually high number of Congolese refugees with enlarged spleens, or splenomegaly. Read More

View Article
December 2018