1,889 results match your criteria Photomedicine and Laser Surgery [Journal]


Effects of red light on inflammation and skin barrier recovery following acute perturbation. Pilot study results in healthy human subjects.

Photodermatol Photoimmunol Photomed 2018 Dec 5. Epub 2018 Dec 5.

Department of Dermatology, Radboud University Medical Center, René Descarstesdreef 1, 6500 HB, Nijmegen, The Netherlands.

In an original article recently published in Photodermatology, Photoimmunology and Photomedicine (1), we aimed to prove therapeutic effects of photobiomodulation (PBM) based on clinical outcomes by investigating the impact of UV-free blue light at 453 nm on the recovery of the skin barrier and on the cutaneous inflammatory response elicited by acute perturbation of the skin of healthy human volunteers. In this Letter we describe a study of same design and scope in which we investigated the impact of LED red light at 656 nm. Briefly, tape stripping and histamine iontophoresis were performed on the forearm of 22 healthy volunteers in two consecutive weeks: in one week, challenges were followed by irradiation with red light at 656 nm, in the other week (control), no light was administered. Read More

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December 2018
2 Reads

Image-Enhanced Endoscopy in Lower Gastrointestinal Diseases: Present and Future.

Clin Endosc 2018 Nov 30;51(6):534-540. Epub 2018 Nov 30.

Division of Gastroenterology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea.

From dye-assisted conventional chromoendoscopy to novel virtual chromoendoscopy, image-enhanced endoscopy (IEE) is continuously evolving to meet clinical needs and improve the quality of colonoscopy. Dye-assisted chromoendoscopy using indigo carmine or crystal violet, although slightly old-fashioned, is still useful to emphasize the pit patterns of the colonic mucosa and predict the histological structures of relevant lesions. Equipment-based virtual chromoendoscopy has the advantage of being relatively easy to use. Read More

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November 2018
1 Read

Shedding light on topical drug uptake.

Authors:
S Jeong C L Evans

Br J Dermatol 2018 Dec;179(6):1245-1246

Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, U.S.A.

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December 2018

Emulsan-based nanoparticles for in vivo drug delivery to tumors.

Biochem Biophys Res Commun 2018 Nov 27. Epub 2018 Nov 27.

Department of Medical Lifescience, College of Medicine, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul, 06591, Republic of Korea; Department of Biomedicine & Health Sciences, College of Medicine, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul, 06591, Republic of Korea; Catholic Photomedicine Research Institute, College of Medicine, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul, 06591, Republic of Korea. Electronic address:

Nanoparticles have been widely used as drug carriers, and finding new materials for them is important for efficient drug delivery. Herein, we developed a new nanoparticle using emulsan and flax seed oil. Emulsan is one of the representative biosurfactants obtained from Acinetobacter calcoaceticus RAG-1. Read More

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November 2018

Comprehensive Study of the Clinical Phenotype of Germline BAP1 Variant-Carrying Families Worldwide.

J Natl Cancer Inst 2018 Dec 4. Epub 2018 Dec 4.

QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.

Background: The BRCA1-associated protein-1 (BAP1) tumor predisposition syndrome (BAP1-TPDS) is a hereditary tumor syndrome caused by germline pathogenic variants in BAP1 encoding a tumor suppressor associated with uveal melanoma, mesothelioma, cutaneous melanoma, renal cell carcinoma, and cutaneous BAP1-inactivated melanocytic tumors. However, the full spectrum of tumors associated with the syndrome is yet to be determined. Improved understanding of the BAP1-TPDS is crucial for appropriate clinical management of BAP1 germline variant carriers and their families, including genetic counseling and surveillance for new tumors. Read More

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December 2018
2 Reads

Novel pharmacotherapy for burn wounds: what are the advancements.

Expert Opin Pharmacother 2018 Dec 5:1-17. Epub 2018 Dec 5.

a Wellman Center for Photomedicine , Massachusetts General Hospital , Boston , MA , USA.

Introduction: The prognosis for severe burns has improved significantly over the past 50 years. Meanwhile, burns have become an affliction mainly affecting the less well-developed regions of the world. Early excision and skin grafting has led to major improvements in therapeutic outcomes. Read More

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December 2018
5 Reads

Inorganic Salts and Antimicrobial Photodynamic Therapy: Mechanistic Conundrums?

Molecules 2018 Dec 3;23(12). Epub 2018 Dec 3.

Laser Research Centre, Faculty of Health Science, University of Johannesburg, Johannesburg, Doornfontein 2028, South Africa.

We have recently discovered that the photodynamic action of many different photosensitizers (PSs) can be dramatically potentiated by addition of a solution containing a range of different inorganic salts. Most of these studies have centered around antimicrobial photodynamic inactivation that kills Gram-negative and Gram-positive bacteria in suspension. Addition of non-toxic water-soluble salts during illumination can kill up to six additional logs of bacterial cells (one million-fold improvement). Read More

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December 2018

Nanoparticulate photosensitizer decorated with hyaluronic acid for photodynamic/photothermal cancer targeting therapy.

Nanomedicine (Lond) 2018 Dec 4. Epub 2018 Dec 4.

Department of Pharmacy, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou 310016, China.

Aim: A photomedicine consisting of a core for photothermal therapy, a photosensitizer for photodynamic therapy, and a cancer-targeting moiety was fabricated to improve photosensitizer selectivity and antitumor efficiency.

Materials & Methods: Hyaluronic acid-decorated polydopamine nanoparticles with conjugated chlorin e6 (HA-PDA-Ce6) were synthesized and characterized. Cell uptake, phototoxicity, penetration, distribution and therapeutic effects were evaluated. Read More

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December 2018

PAMAM dendrimers as efficient drug and gene delivery nanosystems for cancer therapy.

Appl Mater Today 2018 Sep 29;12:177-190. Epub 2018 May 29.

Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA 02114, USA.

Drug delivery systems for cancer chemotherapy are employed to improve the effectiveness and decrease the side-effects of highly toxic drugs. Most chemotherapy agents have indiscriminate cytotoxicity that affects normal, as well as cancer cells. To overcome these problems, new more efficient nanosystems for drug delivery are increasingly being investigated. Read More

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September 2018
3 Reads

A Combination of Visudyne and a Lipid-Anchored Liposomal Formulation of Benzoporphyrin Derivative Enhances Photodynamic Therapy Efficacy in a 3D Model for Ovarian Cancer.

Photochem Photobiol 2018 Nov 29. Epub 2018 Nov 29.

Wellman Center for Photomedicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.

A major objective in developing new treatment approaches for lethal tumors is to reduce toxicity to normal tissues while maintaining therapeutic efficacy. Photodynamic therapy (PDT) provides a mechanistically-distinct approach to treat tumors without the systemic toxicity of chemotherapy drugs. PDT involves the light-based activation of a small molecule, a photosensitizer (PS), to generate reactive molecular species (RMS) that are toxic to target tissue. Read More

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November 2018
2 Reads

Miconazole loaded chitosan-based nanoparticles for local treatment of vulvovaginal candidiasis fungal infections.

Colloids Surf B Biointerfaces 2018 Nov 20;174:409-415. Epub 2018 Nov 20.

Department of Cell Biology, Institute of Biological Sciences, University of Brasília, Brasília, DF, 70910-900, Brazil.

Objectives: In this study, polymeric nanoparticles based on chitosan incorporating the antifungal miconazole nitrate were fabricated and testedin vivo using murine vulvovaginal candidiasis.

Methods: Nanoparticles prepared by the ionotropic gelation method presented 200 to 300 nm diameter and polydispersity indexes ranging from 0.2 to 0. Read More

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November 2018
2 Reads

Multimodal Cancer Theranosis Using Hyaluronate-Conjugated Molybdenum Disulfide.

Adv Healthc Mater 2018 Nov 27:e1801036. Epub 2018 Nov 27.

Department of Materials Science and Engineering, Pohang University of Science and Technology (POSTECH), 77 Cheongam-ro, Nam-gu, Pohang, Gyeongbuk, 37673, Republic of Korea.

Among various 2D nanomaterials, molybdenum disulfide (MoS ) exhibits unique visible photoluminescence with high absorption at the near-infrared (NIR) range. Despite these optical properties, the efforts to use MoS nanomaterials for optical imaging and photothermal therapy are hampered by their instability and low intracellular delivery efficiency. Multifunctional MoS conjugated with hyaluronate (HA) for cancer theranosis is reported herein. Read More

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November 2018
2 Reads

Laser-assisted delivery enhances topical uptake of the anticancer agent cisplatin.

Drug Deliv 2018 Nov;25(1):1877-1885

a Department of Dermatology , Bispebjerg Hospital, University of Copenhagen , Copenhagen NV , Denmark.

Systemic chemotherapy with the anticancer agent cisplatin is approved for advanced non-melanoma skin cancer (NMSC), but topical treatment is limited by insufficient cutaneous penetration. We studied the impact of ablative fractional laser (AFL) exposure on topical cisplatin's pharmacokinetics and biodistribution in skin, using microscopic ablation zones reaching the mid- (MAZ-MD; 620 μm depth) and deep dermis (MAZ-DD; 912 μm depth) (λ = 10,600 nm, 196 MAZ/cm). Assessed in an in vitro Franz cell model after 0. Read More

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November 2018
4 Reads

Photobiomodulation Improves the Frontal Cognitive Function of Older Adults.

Int J Geriatr Psychiatry 2018 Nov 26. Epub 2018 Nov 26.

Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

Objectives: The frontal lobe hypothesis of age-related cognitive decline suggests that the deterioration of the prefrontal cortical regions that occurs with aging leads to executive function deficits. Photobiomodulation (PBM) is a newly developed, non-invasive technique for enhancing brain function, which has shown promising effects on cognitive function in both animals and humans. This randomized, sham-controlled study sought to examine the effects of PBM on the frontal brain function of older adults. Read More

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November 2018
3 Reads

A rodent model of anterior ischemic optic neuropathy (AION) based on laser photoactivation of verteporfin.

BMC Ophthalmol 2018 Nov 22;18(1):304. Epub 2018 Nov 22.

Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, NO.100, Haining Road, Hongkou District, Shanghai, 200080, China.

Background: A rodent model of photodynamic AION resulting from intravenous verteporfin is presented. The analysis of the morphological function, the pathological changes and the potential mechanism of action were further investigated.

Methods: Photodynamic treatment was conducted on the optic nerve head (ONH) following administration of the photosensitizer. Read More

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November 2018
1 Read

Hydrogen Peroxide Enhances the Antibacterial Effect of Methylene Blue-based Photodynamic Therapy on Biofilm-forming Bacteria.

Photochem Photobiol 2018 Nov 22. Epub 2018 Nov 22.

Catholic Photomedicine Research Institute, the Catholic University of Korea, Seoul, Korea.

Recently, increased attention has been focused on endoscopic disinfection after outbreaks of drug resistant infections associated with gastrointestinal endoscopy. The aims of this study were to investigate the bactericidal efficacy of methylene blue (MB)-based photodynamic therapy (PDT) on Pseudomonas aeruginosa (P. aeruginosa), which is the major cause of drug resistant post-endoscopy outbreak, and to assess the synergistic effects of hydrogen peroxide addition to MB-based PDT on biofilms. Read More

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November 2018
1 Read

Mapping the phase and amplitude of ossicular chain motion using sound-synchronous optical coherence vibrography.

Biomed Opt Express 2018 Nov 17;9(11):5489-5502. Epub 2018 Oct 17.

Harvard-MIT Division of Health Sciences and Technology, Cambridge, MA, USA.

The sound-driven vibration of the tympanic membrane and ossicular chain of middle-ear bones is fundamental to hearing. Here we show that optical coherence tomography in phase synchrony with a sound stimulus is well suited for volumetric, vibrational imaging of the ossicles and tympanic membrane. This imaging tool - OCT vibrography - provides intuitive motion pictures of the ossicular chain and how they vary with frequency. Read More

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November 2018
2 Reads

Robust reconstruction of local optic axis orientation with fiber-based polarization-sensitive optical coherence tomography.

Biomed Opt Express 2018 Nov 15;9(11):5437-5455. Epub 2018 Oct 15.

Optical + Biomedical Engineering Laboratory, Department of Electrical, Electronic and Computer Engineering, The University of Western Australia, Perth, WA 6009, Australia.

It is challenging to recover local optic axis orientation from samples probed with fiber-based polarization-sensitive optical coherence tomography (PS-OCT). In addition to the effect of preceding tissue layers, the transmission through fiber and system elements, and imperfect system alignment, need to be compensated. Here, we present a method to retrieve the required correction factors from measurements with depth-multiplexed PS-OCT, which accurately measures the full Jones matrix. Read More

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November 2018
2 Reads

Characterization of human cutaneous tissue autofluorescence: implications in topical drug delivery studies with fluorescence microscopy.

Biomed Opt Express 2018 Nov 12;9(11):5400-5418. Epub 2018 Oct 12.

BioPharmX, Inc., 1505 Adams Drive Suite D, Menlo Park, CA 94025, USA.

In pharmacokinetic studies of topical drugs, fluorescence microscopy methods can enable the direct visualization and quantification of fluorescent drugs within the skin. One potential limitation of this approach, however, is the strong endogenous fluorescence of skin tissues that makes straightforward identification of specific drug molecules challenging. To study this effect and quantify endogenous skin fluorescence in the context of topical pharmacokinetics, an integrating sphere-based screening tool was designed to collect fluorescence yield data from human skin specimens. Read More

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November 2018
2 Reads

Evaluating the Potential for Resistance Development to Antimicrobial Blue Light (at 405 nm) in Gram-Negative Bacteria: and Studies.

Front Microbiol 2018 16;9:2403. Epub 2018 Oct 16.

Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.

Antimicrobial resistance is a threat to public health that requires our immediate attention. With increasing numbers of microbes that are becoming resistant to routinely used antimicrobials, it is vital that we look to other, non-traditional therapies for the treatment of infections. Antimicrobial blue light (aBL) is an innovative approach that has demonstrated efficacy for the inactivation of an array of microbial pathogens. Read More

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October 2018
2 Reads

Antimicrobial Photodynamic Inactivation Mediated by Tetracyclines in Vitro and in Vivo: Photochemical Mechanisms and Potentiation by Potassium Iodide.

Sci Rep 2018 Nov 20;8(1):17130. Epub 2018 Nov 20.

Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA, USA.

Tetracyclines (including demeclocycline, DMCT, or doxycycline, DOTC) represent a class of dual-action antibacterial compounds, which can act as antibiotics in the dark, and also as photosensitizers under illumination with blue or UVA light. It is known that tetracyclines are taken up inside bacterial cells where they bind to ribosomes. In the present study, we investigated the photochemical mechanism: Type 1 (hydroxyl radicals); Type 2 (singlet oxygen); or Type 3 (oxygen independent). Read More

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November 2018
4 Reads

Nanopharmaceuticals and nanomedicines currently on the market: challenges and opportunities.

Nanomedicine (Lond) 2018 Nov 19. Epub 2018 Nov 19.

Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.

There has been a revolution in nanotechnology and nanomedicine. Since 1980, there has been a remarkable increase in approved nano-based pharmaceutical products. These novel nano-based systems can either be therapeutic agents themselves, or else act as vehicles to carry different active pharmaceutical agents into specific parts of the body. Read More

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November 2018
1 Read

A quantitative comparison of five optical coherence tomography angiography systems in clinical performance.

Int J Ophthalmol 2018 18;11(11):1784-1795. Epub 2018 Nov 18.

Department of Ophthalmology, Shanghai General Hospital Affiliated to Shanghai Jiao Tong University, Shanghai 200080, China.

Aim: To compare the clinical performance of 4 spectral-domain (SD) optical coherence tomography angiography (OCTA) systems: AngioVue™, AngioPlex™, Spectralis OCTA, AngioScan, and 1 swept-source (SS) OCTA SS OCT Angio™.

Methods: Twenty-seven undilated right eyes of 27 participants underwent OCTA examination using five different systems respectively for both 3×3 and 6×6 mm scan pattern (Spectralis OCTA for 3×3 mm scan only). Image quality, including vessel valid visibility and the number of motion artifacts, and acquisition time were evaluated. Read More

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November 2018
1 Read

Topical Application of a Vitamin A Derivative and Its Combination With Non-ablative Fractional Laser Potentiates Cutaneous Influenza Vaccination.

Front Microbiol 2018 30;9:2570. Epub 2018 Oct 30.

Key Laboratory of Medical Molecular Virology of MOE/MOH, School of Basic Medical Sciences & Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.

Skin contains a large number of antigen presenting cells, making intradermal (ID) injection one of the most effective ways for vaccine administration. However, although current adjuvants may cause severe local reactions and inflammations in the skin, no adjuvant has been approved for ID vaccination so far. Here, we report that topical application of all- retinoic acid (ATRA), a vitamin A derivative produced in the human body, augmented cutaneous influenza vaccination. Read More

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October 2018
6 Reads

[Guideline Recommendation for Endpoints Used in Clinical Trials for Functional Dyspepsia].

Korean J Gastroenterol 2018 Oct;72(4):170-178

Division of Gastroenterology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Functional dyspepsia is a disease, in which there is no organic lesion but chronic and repetitive postprandial fullness, early satiation, epigastric pain, and epigastric burning. Functional dyspepsia is not life-threatening but its symptoms are relapsing and remitting and persist over a lifetime, limiting the social life and reducing the quality of life. Therefore, the treatment for acute relapsing period may help improve the short-term symptoms. Read More

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October 2018
4 Reads

Beyond the Roles in Biomimetic Chemistry: An Insight into the Intrinsic Catalytic Activity of an Enzyme for Tumor-Selective Phototheranostics.

ACS Nano 2018 Nov 16. Epub 2018 Nov 16.

Institute of Photomedicine, Shanghai Skin Disease Hospital, The Institute for Biomedical Engineering and Nano Science , Tongji University School of Medicine , Shanghai 200443 , China.

Protein-assisted biomimetic synthesis has been an emerging offshoot of nanofabrication in recent years owing to its features of green chemistry, facile process, and ease of multi-integration. As a result, many proteins have been used for biomimetic synthesis of varying kinds of nanostructures. Although the efforts on exploring new proteins and investigating their roles in biomimetic chemistry are increasing, the most essential intrinsic properties of proteins are largely neglected. Read More

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November 2018
4 Reads

Apparatus for Harvesting Tissue Microcolumns.

J Vis Exp 2018 Oct 25(140). Epub 2018 Oct 25.

Wellman Center for Photomedicine, Massachusetts General Hospital; Department of Dermatology, Harvard Medical School.

This manuscript describes the production process for a laboratory apparatus, made from off-the-shelf components, that can be used to collect microcolumns of full-thickness skin tissue. The small size of the microcolumns allows donor sites to heal quickly without causing donor site scarring, while harvesting full-thickness tissue enables the incorporation of all cellular and extracellular components of skin tissue, including those associated with deeper dermal regions and the adnexal skin structures, which have yet to be successfully reproduced using conventional tissue engineering techniques. The microcolumns can be applied directly into skin wounds to augment healing, or they can be used as the autologous cell/tissue source for other tissue engineering approaches. Read More

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October 2018
2 Reads

Flexible quantum dot light-emitting devices for targeted photomedical applications.

J Soc Inf Disp 2018 May 4;26(5):296-303. Epub 2018 May 4.

College of Optics and Photonics, University of Central Florida, Orlando, FL, USA. Nanoscience Technology Center, University of Central Florida, Orlando, FL, USA. Department of Materials Science & Engineering, University of Central Florida, Orlando, FL, USA.

Quantum dot light-emitting devices (QLEDs), originally developed for displays, were recently demonstrated to be promising light sources for various photomedical applications, including photodynamic therapy cancer cell treatment and photobimodulation cell metabolism enhancement. With exceptional emission wavelength tunability and potential flexibility, QLEDs could enable wearable, targeted photomedicine with maximized absorption of different medical photosensitizers. In this paper, we report, for the first time, the in vitro study to demonstrate that QLEDs-based photodynamic therapy can effectively kill Methicillin-resistant , an antibiotic-resistant bacterium. Read More

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May 2018
3 Reads

A Unique Pattern of Staphylococcal Scalded Skin Syndrome-Like Erosions in Patients with Atopic Dermatitis: Dermatitis flammeus.

Skinmed 2018 9;16(5):309-313. Epub 2018 Nov 9.

Division of Dermatology, Department of Medicine, The University of Hong Kong, Hong Kong SAR.

We describe the clinical features of a novel complication in patients with atopic dermatitis (AD). Twenty patients, mean age 23 years, with AD who presented with staphylococcal scalded skin syndrome (SSSS)-like lesions were included between January 2008 and September 2010. Skin lesions followed a triphasic progression pattern from erythema to hyperpigmentation and then erosions. Read More

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November 2018
4 Reads

Effects of androsterone on the protective action of various antiepileptic drugs against maximal electroshock-induced seizures in mice.

Psychoneuroendocrinology 2018 Oct 28;101:27-34. Epub 2018 Oct 28.

Department of Pathophysiology, Medical University of Lublin, Jaczewskiego 8b, PL, 20-090, Lublin, Poland.

This study evaluated the effect of androsterone (AND), a metabolite of testosterone, on the ability of selected classical and novel antiepileptic drugs to prevent seizures caused by maximal electroshock (MES), which may serve as an experimental model of human generalized tonic-clonic seizures in mice. Single intraperitoneal (i.p. Read More

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October 2018
10 Reads

Present and future perspective of photodynamic therapy for cutaneous squamous cell carcinoma.

J Am Acad Dermatol 2018 Oct 27. Epub 2018 Oct 27.

Institute of Photomedicine, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, China. Electronic address:

Cutaneous squamous cell carcinoma (cSCC) is the second most common skin cancer. Surgery remains the main stay of treatment but, some patients are not eligible for surgery and more importantly, lesions at critical site need nonsurgical approach for tissue preservation. In this context, photodynamic therapy (PDT) has been extensively studied as noninvasive or minimally invasive treatment and studies have shown promising results in terms of safety, efficacy and cosmetic outcome. Read More

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October 2018
2 Reads

Guidelines of care for the management of primary cutaneous melanoma.

J Am Acad Dermatol 2018 Oct 29. Epub 2018 Oct 29.

American Academy of Dermatology, Rosemont, Illinois.

The incidence of primary cutaneous melanoma continues to increase each year. Melanoma accounts for the majority of skin cancer-related deaths, but treatment is usually curative following early detection of disease. In this American Academy of Dermatology clinical practice guideline, updated treatment recommendations are provided for patients with primary cutaneous melanoma (American Joint Committee on Cancer stages 0-IIC and pathologic stage III by virtue of a positive sentinel lymph node biopsy). Read More

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October 2018
6 Reads

Anthelmintic resistance and novel control options in equine gastrointestinal nematodes.

Parasitology 2018 Nov 5:1-13. Epub 2018 Nov 5.

Faculty of Health and Medical Sciences, Department of Veterinary and Animal Sciences,University of Copenhagen,Frederiksberg,Denmark.

Control of equine nematodes has relied on benzimidazoles (BZs), tetrahydropyrimidines and macrocyclic lactones. The intensive use of anthelmintics has led to the development of anthelmintic resistance (AR) in equine cyathostomins and Parascaris equorum. Field studies indicate that BZ and pyrantel resistance is widespread in cyathostomins and there are also increasing reports of resistance to macrocyclic lactones in cyathostomins and P. Read More

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November 2018
3 Reads
2.560 Impact Factor

Near-Infrared Photobiomodulation Combined with Coenzyme Q for Depression in a Mouse Model of Restraint Stress: Reduction in Oxidative Stress, Neuroinflammation, and Apoptosis.

Brain Res Bull 2018 Oct 29. Epub 2018 Oct 29.

Neurosciences Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address:

This study was aimed to evaluate the effects of near-infrared (NIR) photobiomodulation (PBM) combined with coenzyme Q (CoQ) on depressive-like behavior, cerebral oxidative stress, inflammation, and apoptosis markers in mice. To induce a depressive-like model, mice were subjected to sub-chronic restraint stress for 5 consecutive days. NIR PBM (810 nm laser, 33. Read More

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October 2018
1 Read
2.720 Impact Factor

Intravascular optical coherence tomography.

Eur Heart J 2018 Nov;39(41):3685-3686

Remondi Family Foundation Endowed, MGH Research Institute, Harvard Medical School, Massachusetts General Hospital, Department of Pathology, Wellman Center for Photomedicine, Boston, MA, USA, Tel: +1 617 724-2979, Fax: +1 617 726-4103.

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November 2018
1 Read

Correction: Photobiomodulation: lasers vs. light emitting diodes?

Photochem Photobiol Sci 2018 Oct 31. Epub 2018 Oct 31.

Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA 02114, USA and Department of Dermatology, Harvard Medical School, Boston, MA 02115, USA and Harvard-MIT Division of Health Sciences and Technology, Cambridge, MA 02139, USA.

Correction for 'Photobiomodulation: lasers vs. light emitting diodes?' by Vladimir Heiskanen and Michael R. Hamblin, Photochem. Read More

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October 2018

Physical activation of innate immunity by spiky particles.

Nat Nanotechnol 2018 Nov 29;13(11):1078-1086. Epub 2018 Oct 29.

State Key Laboratory of Optoelectronic Materials and Technologies, School of Electronics and Information Technology, Guangdong Province Key Laboratory of Display Material and Technology, The First Affiliated Hospital of Sun Yat-Sen University, Sun Yat-Sen University, Guangzhou, China.

Microbial biochemicals have been indicated as the primary stimulators of innate immunity, the first line of the body's defence against infections. However, the influence of topological features on a microbe's surface on immune responses remains largely unknown. Here we demonstrate the ability of TiO microparticles decorated with nanospikes (spiky particles) to activate and amplify the immune response in vitro and in vivo. Read More

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November 2018
17 Reads
34.050 Impact Factor

Emerging Potential of Immediate Early Response Gene X-1 in Cardiovascular and Metabolic Diseases.

J Am Heart Assoc 2018 Nov;7(21):e009261

3 The Wellman Center for Photomedicine Department of Dermatology Massachusetts General Hospital Harvard Medical School Boston MA.

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November 2018
2 Reads

An extremely low frequency-weak magnetic field can induce alterations in a biological system: A case study in chick embryo development.

Prog Biophys Mol Biol 2018 Oct 23. Epub 2018 Oct 23.

National Institute of Laser Enhanced Science, Cairo University, Egypt.

The aim of the current study was to investigate the effects of a weak magnetic field at extremely low frequency on a biological system. Our case study was on chick embryo development. Freshly fertilized chicken eggs were subjected to magnetic field (1. Read More

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October 2018
6 Reads

Potential Treatment of Retinal Diseases with Iron Chelators.

Pharmaceuticals (Basel) 2018 Oct 22;11(4). Epub 2018 Oct 22.

F.M. Kirby Center for Molecular Ophthalmology, Scheie Eye Institute, Perelman School of Medicine at the University of Pennsylvania, 305 Stellar-Chance Laboratory, Philadelphia, PA 19104, USA.

Iron is essential for life, while excess iron can be toxic. Iron generates hydroxyl radical, which is the most reactive free radical, causing oxidative stress. Since iron is absorbed through the diet but not excreted from the body, it accumulates with age in tissues, including the retina, consequently leading to age-related toxicity. Read More

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October 2018
6 Reads

Evaluation of the safety and efficacy of the dual wavelength picosecond laser for the treatment of benign pigmented lesions in Asians.

Lasers Surg Med 2018 Oct 25. Epub 2018 Oct 25.

Division of Dermatology, Department of Medicine, The University of Hong Kong, Hong Kong SAR, China.

Background And Objectives: Cutaneous pigmentary disorders are both more common and more difficult to treat in patients with skin color given the higher melanin content in the epidermis. Although Q-switched lasers are widely considered to be the standard treatment for both epidermal and dermal pigmentary conditions, a very high risk of post-inflammatory hyperpigmentation (PIH) of up to 25% is seen in patients with skin of color. Recently, the novel picosecond laser with pulse durations operating at sub-nanosecond domains has been shown to be effective in tattoo removal and in the treatment of acne scars. Read More

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October 2018
14 Reads

LY2109761, Transforming Growth Factor β Receptor Type I and Type II Dual Inhibitor, is a Novel Approach to Suppress Endothelial Mesenchymal Transformation in Human Corneal Endothelial Cells.

Cell Physiol Biochem 2018 24;50(3):963-972. Epub 2018 Oct 24.

Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai, China.

Background/aims: Preventing undesirable endothelial-mesenchymal transformation (EnMT) with repetitious in vitro expansion of human corneal endothelial cells (CECs) is a pivotal issue in cornea regeneration. Previous studies have shown that inhibition of the TGF-β pathway reduces epithelial-mesenchymal transformation. However, its potential role in EnMT remains poorly understood. Read More

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November 2018
5 Reads

Transcatheter embolization effectively controls acute lower gastrointestinal bleeding without localizing bleeding site prior to angiography.

Scand J Gastroenterol 2018 Sep 25;53(9):1089-1096. Epub 2018 Oct 25.

a Division of Gastroenterology, Department of Internal Medicine , College of Medicine, The Catholic University of Korea , Seoul , Korea.

Background And Aims: Colonoscopy is preferred for treatment of lower gastrointestinal bleeding (LGIB). However, several conditions such as poor bowel preparation can cause endoscopic failure, leading to surgery or transcatheter therapy as alternative options. We aimed to assess the efficacy and safety of transcatheter arterial embolization (TAE) for LGIB in patients with endoscopic failure. Read More

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September 2018
5 Reads

Rejuvenation of aged rat skin with pulsed electric fields.

J Tissue Eng Regen Med 2018 Oct 23. Epub 2018 Oct 23.

Center for Engineering in Medicine, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, and the Shriners Burns Hospital, Boston, MA, USA.

The demand for skin rejuvenation procedures has progressively increased in the past decade. Additionally, clinical trials have shown that current therapies might cause downtime and side effects in patients including prolonged erythema, scarring, and dyspigmentation. The goal of this study was to explore the effect of partial irreversible electroporation (pIRE) with pulsed electric fields in aged skin rejuvenation as a novel, noninvasive skin resurfacing technique. Read More

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October 2018

Rose Bengal and Green Light Versus Riboflavin-UVA Cross-Linking: Corneal Wound Repair Response.

Invest Ophthalmol Vis Sci 2018 Oct;59(12):4821-4830

Departamento de Biología Celular, Histología y Farmacología, GIR de Técnicas Ópticas para el Diagnóstico, Universidad de Valladolid, Valladolid, Spain.

Purpose: To study corneal wound healing after two cross-linking techniques using either rose bengal and green light (RGX) or the conventional treatment using riboflavin and UVA radiation (UVX).

Methods: Corneas of New Zealand rabbits were monolaterally treated with UVX (21 eyes) or RGX (25 eyes). Treatments involved corneal de-epithelialization (8-mm diameter), soaking with photosensitizer (0. Read More

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October 2018

Transcranial Photobiomodulation for the Treatment of Major Depressive Disorder. The ELATED-2 Pilot Trial.

Photomed Laser Surg 2018 Oct 20. Epub 2018 Oct 20.

8 Adult Psychopharmacology Program, Department of Psychiatry, Icahn School of Medicine at Mount Sinai , New York, New York.

Objective: Our objective was to test the antidepressant effect of transcranial photobiomodulation (t-PBM) with near-infrared (NIR) light in subjects suffering from major depressive disorder (MDD).

Background: t-PBM with NIR light is a new treatment for MDD. NIR light is absorbed by mitochondria; it boosts cerebral metabolism, promotes neuroplasticity, and modulates endogenous opioids, while decreasing inflammation and oxidative stress. Read More

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October 2018
8 Reads

Bactericidal Property of Oregano Oil Against Multidrug-Resistant Clinical Isolates.

Front Microbiol 2018 5;9:2329. Epub 2018 Oct 5.

Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.

Development of non-antibiotic alternatives to treat infections caused by multidrug-resistant (MDR) microbes represents one of the top priorities in healthcare and community settings, especially in the care of combat trauma-associated wound infections. Here, we investigate efficacy of oregano oil against pathogenic bacteria including MDR isolates from the combat casualties and in a mouse burn model. Oregano oil showed a significant anti-bacterial activity against 11 MDR clinical isolates including four , three , and four methicillin-resistant (MRSA) obtained from combat casualties and two luminescent strains of PA01 and MRSA USA300, with a MIC ranging from 0. Read More

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October 2018
7 Reads

Comprehensive Stability Improvement of Silver Nanowire Networks via Self-Assembled Mercapto Inhibitors.

ACS Appl Mater Interfaces 2018 Oct 19;10(43):37699-37708. Epub 2018 Oct 19.

State Key Laboratory of Optoelectronic Materials and Technologies, Guangdong Province Key Laboratory of Display Material and Technology, School of Electronics and Information Technology , Sun Yat-Sen University , Guangzhou 510006 , China.

Instability of silver nanowire (AgNW) has been regarded as a major obstacle to its practical applications in optoelectrical devices as transparent electrodes. Physical barrier layers such as polymer, metal, and graphene have been generally employed to improve the stability of AgNW in previous study. Herein, we first report self-assembled organothiols as an inhibitor for AgNW to achieve an overall enhancement in antioxidation, antisulfidation, thermal stability, and anti-electromigration. Read More

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October 2018
6.720 Impact Factor

Conventional versus daylight photodynamic therapy for actinic keratosis: a randomized and prospective study in China.

Photodiagnosis Photodyn Ther 2018 Oct 15. Epub 2018 Oct 15.

Institute of Photomedicine, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, China. Electronic address:

Background: Conventional photodynamic therapy (C-PDT) is an effective treatment for actinic keratoses (AKs) in Asia, with some unmet needs. Severe PDT-associated pain results in low treatment willingness. Daylight photodynamic therapy (DL-PDT) is a more simple and tolerable treatment that has the same efficacy as C-PDT in Europe. Read More

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October 2018
1 Read

Increased Vertical Asymmetry of Macular Retinal Layers in Myopic Chinese Children.

Curr Eye Res 2018 Oct 18:1-11. Epub 2018 Oct 18.

a Department of Preventative Ophthalmology, Shanghai Eye Disease Prevention and Treatment Center , Shanghai Eye Hospital , Shanghai , China.

Purpose: The purpose of this project is to explore the changes in and factors associated with asymmetry between the superior and inferior hemiretina in children with different refractive levels.

Materials And Methods: A total of 2964 children from 12 primary and middle schools in Shanghai, China, were included. The mean thickness of the GCL+ layer (ganglion cell layer+ inner plexiform layer), the GCC layer (ganglion cell complex, a combination of the retinal nerve fiber layer and the GCL+ layer), and the neural retina was measured according to the sectors defined by the Early Treatment of Diabetic Retinopathy Study (ETDRS) grid with swept-source optical coherence tomography. Read More

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October 2018
11 Reads