21,197 results match your criteria Photodynamic Therapy for the Dermatologist


The effects of repeated applications of antimicrobial photodynamic therapy in the treatment of residual periodontal pockets: a systematic review.

Lasers Med Sci 2018 Dec 11. Epub 2018 Dec 11.

Department of Periodontology, Master of Science Program, Veiga de Almeida University, Rua Ibituruna 108, casa 3, sala 201, Tijuca, Rio de Janeiro, 20271-020, Brazil.

The aim of this study was to assess the effects of repeated applications of antimicrobial photodynamic therapy (aPDT) on the non-surgical periodontal treatment of residual pockets. This work was performed and reported according to the Cochrane and PRISMA recommendations, respectively, and registered at the PROSPERO registry (number CRD42017058403). An extensive search of the biomedical literature was conducted on four databases from January 1960 to August 2018, followed by hand searching. Read More

View Article
December 2018

Novel pH-sensitive zinc phthalocyanine assembled with albumin for tumor targeting and treatment.

Int J Nanomedicine 2018 19;13:7681-7695. Epub 2018 Nov 19.

College of Chemistry, Fuzhou University, Fuzhou, Fujian, China.

Purpose: Zinc phthalocyanine (ZnPc) has been applied widely in photodynamic therapy (PDT) with high ROS-production capacity and intense absorption in the near-infrared region. However, weak tumor targeting and the aggregation tendency of ZnPc seriously affect the therapeutic effect of PDT. Therefore, overcoming the aggregation of ZnPc and enhancing its antitumor effect were the purpose of this study. Read More

View Article
November 2018

Enhanced photo/chemo combination efficiency against bladder tumor by encapsulation of DOX and ZnPC into in situ-formed thermosensitive polymer hydrogel.

Int J Nanomedicine 2018 19;13:7623-7631. Epub 2018 Nov 19.

Department of Urology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China,

Background: Chemotherapy after transurethral resection is commonly recommended for bladder cancer. However, studies have shown that chemotherapy solely can hardly decrease progression rates of bladder cancer. The combination of chemotherapeutic agents with photo-dynamic therapy (PDT), a new promising localized therapy, may become a workable strategy for combating bladder cancer. Read More

View Article
November 2018

A Phase-change Material Packaged within Hollow Copper Sulfide Nanoparticles Carrying Doxorubicin and Chlorin e6 for Fluorescence-guided Trimodal Therapy of Cancer.

ACS Appl Mater Interfaces 2018 Dec 12. Epub 2018 Dec 12.

Environmental stimuli, including pH, light and temperature, have been utilized for activating controlled drug delivery to achieve efficient antitumor therapeutics while minimizing undesirable side effects. In this study, a multifunctional nanoplatform based on hollow mesoporous copper sulfide nanoparticles (H-CuS NPs) was developed by loading the interior cavity of the NPs with a drug-loaded phase change material (PCM, 1-tetradecanol). Doxorubicin (DOX) and chlorin e6 (Ce6) were selected as the model chemotherapeutic drug and photosensitizer, respectively, which were encapsulated in H-CuS NPs via the PCM to form H-CuS@PCM/DOX/Ce6 (HPDC) NPs. Read More

View Article
December 2018

Sodium nitrite potentiates antimicrobial photodynamic inactivation: possible involvement of peroxynitrate.

Photochem Photobiol Sci 2018 Dec 11. Epub 2018 Dec 11.

Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA 02114, USA. and Department of Dermatology, Harvard Medical School, Boston, MA 02115, USA and Harvard-MIT Division of Health Sciences and Technology, Cambridge, MA 02139, USA.

We have recently shown that a wide range of different inorganic salts can potentiate antimicrobial photodynamic inactivation (aPDI) and TiO2-mediated antimicrobial photocatalysis. Potentiation has been shown with azide, bromide, thiocyanate, selenocyanate, and most strongly, with iodide. Here we show that sodium nitrite can also potentiate broad-spectrum aPDI killing of Gram-positive MRSA and Gram-negative Escherichia coli bacteria. Read More

View Article
December 2018

Hypericin photodynamic activity. Part III: in vitro evaluation in different nanocarriers against trypomastigotes of Trypanosoma cruzi.

Photochem Photobiol Sci 2018 Dec 10. Epub 2018 Dec 10.

Departamento de Química, Universidade Estadual de Maringá, 87020-900, Maringá, Paraná, Brazil.

Chagas is a parasitic endemic disease caused by the protozoan Trypanosoma cruzi. It represents a strong threat to public health due to its strong resistance against commonly available drugs. We studied the in vitro ability to inactivate the trypomastigote form of this parasite using photodynamic inactivation of microorganisms (or antimicrobial Photodynamic Therapy, aPDT). Read More

View Article
December 2018

A facile fabrication of novel stuff with antibacterial property and osteogenic promotion utilizing red phosphorus and near-infrared light.

Bioact Mater 2019 Mar 23;4(1):17-21. Epub 2018 Nov 23.

Ministry-of-Education Key Laboratory for the Green Preparation and Application of Functional Materials, Hubei Key Laboratory of Polymer Materials, School of Materials Science & Engineering, Hubei University, Wuhan, 430062, China.

Bone-implant materials are important for bone repairing and orthopedics surgery, which include bone plates and bone nails. These materials need to be designed not only considering its biostability and biocompatibility, but also their by-products induced infection after therapy or long-time treatment . Thus, the development of novel implant materials is quite urgent. Read More

View Article

Prevalence of elevated microsatellite alterations at selected tetranucleotide repeats in pancreatic ductal adenocarcinoma.

PLoS One 2018 7;13(12):e0208557. Epub 2018 Dec 7.

First Department of Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan.

Pancreatic ductal adenocarcinoma (PDAC) prognosis remains poor even after complete resection owing to no valuable biomarkers for recurrence and chemosensitivity. Tumors not expressing MSH3 show elevated microsatellite alterations at selected tetranucleotide repeats (EMAST). EMAST reportedly occurs in several tumors. Read More

View Article
December 2018

A two-year study of diffused retinal pigment epitheliopathy treated with half-dose photodynamic therapy guided by simultaneous angiography and optical coherence tomography.

Eye (Lond) 2018 Dec 7. Epub 2018 Dec 7.

Department of Ophthalmology, Eye and ENT Hospital of Fudan University, Shanghai, 200032, China.

Objectives: Diffused retinal pigment epitheliopathy (DRPE) is not necessarily the same as chronic central serous chorioretinopathy (CSC), but a severe subgroup under the umbrella of chronic CSC. This study was to evaluate the efficacy and safety of half-dose PDT treating DRPE.

Methods: A retrospective case series design was used. Read More

View Article
December 2018

Curettage and multiple needle puncture-assisted methyl-aminolaevulinate photodynamic therapy of basal cell carcinoma.

Eur J Dermatol 2018 Dec 10. Epub 2018 Dec 10.

University of Northern Norway, Institute of Clinical Medicine, Tromsø, Norway, Lillehammer Dermatological Clinic, Lillehammer, Norway.

The use of skin puncture techniques may facilitate the delivery of topically applied drugs for photodynamic therapy (PDT). The main aim of this prospective study was to evaluate the efficacy and cosmetic outcome of curettage, multiple needle puncture, and methyl-aminolaevulinate (MAL)-PDT in basal cell carcinoma (BCC). All tumours received curettage and 15-20 needle punctures/cm before two sessions of MAL-PDT. Read More

View Article
December 2018

Interfacial uploading of luminescent hexamolybdenum cluster units onto amino-decorated silica nanoparticles as new design of nanomaterial for cellular imaging and photodynamic therapy.

J Colloid Interface Sci 2018 Dec 4;538:387-396. Epub 2018 Dec 4.

Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of RAS, Arbuzov str., 8, 420088 Kazan, Russia.

The present work introduces a facile synthetic route to embed phosphorescent K[{MoI}I] and (nBuN)[{MoI}(CHCOO)] clusters (C) onto silica-water interface of amino-decorated silica nanoparticles (SNs, 60 ± 6 nm). The assembled C-SNs gain in the luminescence intensity, which remains stable within three months after their assembly. High uptake capacity of the clusters (8700 of K[{MoI}I] and 6500 of (nBuN)[{MoI}(CHCOO)] per the each nanoparticle) derives from ionic self-assembly and coordination bonds between the cluster complexes and ionic (amino- and siloxy-) groups at the silica surface. Read More

View Article
December 2018

Nanosoldiers: A promising strategy to combat triple negative breast cancer.

Biomed Pharmacother 2018 Dec 3;110:319-341. Epub 2018 Dec 3.

Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management, SVKM's NMIMS, V.L. Mehta Road, Vile Parle (W), Mumbai, 400056, India. Electronic address:

The phenomenal rise in cancer over the past few years has made it the second leading cause of death worldwide. Breast cancer constitutes the predominant cancer encountered in women. Triple negative breast cancer (TNBC) is the most notorious form of breast cancer which involves absence of the estrogen, progesterone and human epidermal growth factor receptor (EGFR) on breast cancer cells. Read More

View Article
December 2018

[Photodynamic therapy for the treatment of glioblastoma in neurosurgery].

Med Sci (Paris) 2018 Nov 10;34(11):901-903. Epub 2018 Dec 10.

Université de Lille, Inserm, CHU de Lille, U1189 - ONCO-THAI - Thérapies laser assistées par l'image pour l'oncologie, 59000 Lille, France.

View Article
November 2018

Hybrid Silver Nanocubes for Improved Plasmon-Enhanced Singlet Oxygen Production and Inactivation of Bacteria.

J Am Chem Soc 2018 Dec 9. Epub 2018 Dec 9.

Plasmonic nanoparticles can strongly interact with adjacent photosensitizer molecules, resulting in significant alteration of their singlet oxygen (1O2) production. In this work, we report the next generation of metal-enhanced 1O2 nanoplatforms exploiting the lightning rod effect, or plasmon hot spots, in anisotropic (non-spherical) metal nanoparticles. We describe the synthesis of Rose Bengal decorated silica-coated silver nanocubes (Ag@SiO2-RB NCs) with silica shell thicknesses ranging from 5 to 50 nm based on an optimized protocol yielding highly homogeneous Ag NCs. Read More

View Article
December 2018

Sensitive, Real-Time and In-Vivo Oxygen Monitoring for Photodynamic Therapy by Multifunctional Mesoporous Nanosensors.

ACS Appl Mater Interfaces 2018 Dec 10. Epub 2018 Dec 10.

Real-time monitoring of oxygen consumption is beneficial to predict treatment response and optimize therapeutic protocols for photodynamic therapy (PDT). In this work, we first demonstrate that deformable hollow mesoporous organosilica nanoparticles (HMONs) can be used to load [(Ru(dpp)3)]Cl2 for detecting oxygen (denoted as HMON-[(Ru(dpp)3)]Cl2). This nanoprobe shows significantly improved biocompatibility and high cellular uptake. Read More

View Article
December 2018

Visible-light-responsive Photocatalyst of Graphitic Carbon Nitride for Pathogenic Biofilm Control.

ACS Appl Mater Interfaces 2018 Dec 7. Epub 2018 Dec 7.

Pathogenic biofilms raise significant health and economic concerns, because these bacteria are persistent and can lead to long-term infections in vivo and surface contamination in healthcare and industrial facilities or devices. Compared with conventional antimicrobial strategies, photocatalysis holds promise for biofilm control because of its broad-spectrum effectiveness under ambient conditions, low cost, easy operation, and reduced maintenance. In this study, we investigated the performance and mechanism of Staphylococcus epidermidis biofilm control and eradication on the surface of an innovative photocatalyst, graphitic carbon nitride (g-C3N4), under visible light irradiation, which overcame the need for ultraviolet (UV) light for many current photocatalysts (e. Read More

View Article
December 2018

Oxidation of cystatin imparted by riboflavin generated free radicals: Spectral analysis.

Int J Biol Macromol 2018 Dec 3. Epub 2018 Dec 3.

Department of Biochemistry, Faculty of life sciences, Aligarh Muslim University, Aligarh, UP 202002, India. Electronic address:

Thiol Protease inhibitors (cystatins) are endogenous natural inhibitors of cysteine proteases. They are present in all mammalians cells and body fluids. Cystatin are allocated into three major families. Read More

View Article
December 2018
5 Reads

[Treatment algorithm for non-melanoma skin cancer].

Ugeskr Laeger 2018 Nov;180(48)

Non-melanoma skin cancers are the most common malignant neoplasms in Denmark. The majority of cases are basal cell carcinomas (BCC) and squamous cell carcinomas (SCC). The choice of treatment depends on tumour, area, histology and patient-specific factors. Read More

View Article
November 2018

Photodynamic therapy in dermatology.

Authors:
Lasse R Braathen

G Ital Dermatol Venereol 2018 Dec;153(6):763

Dermatologist, Bern University Hospital, Bern, Switzerland -

View Article
December 2018
1 Read

LOW-LEVEL LIGHT-ASSISTED PHOTODYNAMIC THERAPY USING A WEARABLE CAP-LIKE DEVICE FOR THE TREATMENT OF ACTINIC KERATOSIS OF THE SCALP.

Photodiagnosis Photodyn Ther 2018 Nov 30. Epub 2018 Nov 30.

Dermatology Department, Ramón y Cajal Hospital, Madrid, Spain. Electronic address:

Background: Daylight photodynamic therapy (dlPDT) is a painless and increasingly cost-effective treatment for actinic keratosis (AK). New protocols avoid incubation minimizing pain and adverse events. However, it is time-consuming and dependent on specific weather conditions. Read More

View Article
November 2018
2 Reads

Highly Stable and Multifunctional Aza-BODIPY-Based Phototherapeutic Agent for Anticancer Treatment.

ACS Appl Mater Interfaces 2018 Dec 3. Epub 2018 Dec 3.

Phototherapy, as an important class of noninvasive tumor treatment methods, has attracted extensive research interest. Although a large amount of the near-infrared (NIR) phototherapeutic agents have been reported, the low efficiency, complicated structures, tedious synthetic procedures, and poor photostability limit their practical applications. To solve these problems, herein, a donor-acceptor-donor (D-A-D) type organic phototherapeutic agent (B-3) based on NIR aza-boron-dipyrromethene (aza-BODIPY) dye has been constructed, which shows the enhanced photothermal conversion efficiency and high singlet oxygen generation ability by simultaneously utilizing intramolecular photoinduced electron transfer (IPET) mechanism and heavy atom effects. Read More

View Article
December 2018

Shedding light on photodynamic therapy for basal cell carcinoma.

Authors:
Henry W Lim

Br J Dermatol 2018 Dec;179(6):1240-1241

Department of Dermatology, Henry Ford Hospital, Henry Ford Medical Center - New Center One, 3031 West Grand Blvd, Suite 800, Detroit, MI, 48202, U.S.A.

View Article
December 2018

Innovative treatment for hepatocellular carcinoma (HCC).

Transl Gastroenterol Hepatol 2018 22;3:78. Epub 2018 Oct 22.

Division of Hepato-Biliary-Pancreatic Surgery, Department of Surgery, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.

Indocyanine green (ICG) is not new in the field of liver surgery. Early studies performed in the 1980s and 1990s revealed the value of the ICG clearance test in predicting post-hepatectomy morbidity and mortality. ICG clearance and retention tests are crucial for determining precise liver function before liver surgery and offer several benefits for safe surgery. Read More

View Article
October 2018
1 Read

Mitochondria-targeting drug conjugates for cytotoxic, anti-oxidizing and sensing purposes: current strategies and future perspectives.

Acta Pharm Sin B 2018 Oct 18;8(6):862-880. Epub 2018 May 18.

Department of Pharmacy, Integrated Research Institute of Pharmaceutical Sciences, and BK21 PLUS Team for Creative Leader Program for Pharmacomics-based Future Pharmacy, College of Pharmacy, The Catholic University of Korea, Gyeonggi-do 14662, Republic of Korea.

Mitochondrial targeting is a promising approach for solving current issues in clinical application of chemotherapy and diagnosis of several disorders. Here, we discuss direct conjugation of mitochondrial-targeting moieties to anticancer drugs, antioxidants and sensor molecules. Among them, the most widely applied mitochondrial targeting moiety is triphenylphosphonium (TPP), which is a delocalized cationic lipid that readily accumulates and penetrates through the mitochondrial membrane due to the highly negative mitochondrial membrane potential. Read More

View Article
October 2018
3 Reads

Central serous chorioretinopathy: Current update on management.

Oman J Ophthalmol 2018 Sep-Dec;11(3):200-206

Department of Vitreo-Retina Services, Aravind Eye Hospital and Postgraduate Institute of Ophthalmology, Coimbatore, Tamil Nadu, India.

Central serous chorioretinopathy (CSC), the fourth most common nonsurgical retinopathy with a usual self-limiting course, is known to present with persistent or recurrent form with distressing visual loss. Evolution of newer mutimodal imaging techniques have revolutionized the understanding about the pathophysiology of CSC, and hence the diagnosis and management. Multifactorial etiopathology of CSC promotes the use of multiple treatment modalities. Read More

View Article
December 2018
1 Read

Optimized Scintillator YAG:Pr Nanoparticles for X-ray Inducible Photodynamic Therapy.

Mater Lett 2018 Oct 20;228:49-52. Epub 2018 May 20.

University of California, San Diego, Department of Mechanical and Aerospace Engineering, 9500 Gilman Drive - MC 0411, La Jolla, CA 92093-0411, USA.

We describe a sol-gel synthetic method for the production of praseodymium-doped yttrium aluminum garnet (YAG) nanoparticles suitable for X-ray inducible photodynamic therapy (X-PDT). Our sol-gel based approach was optimized by varying temperature and time of calcination, resulting in nanoparticles that were smooth, spherical, and 50-200 nm in crystallite size. The powders were uniformly coated with a thin (10 nm) layer of silica to facilitate surface conjugation with functional moieties. Read More

View Article
October 2018

An update on recent developments in the prevention and treatment of Staphylococcus aureus biofilms.

Int J Med Microbiol 2018 Nov 27. Epub 2018 Nov 27.

Center for Nanosciences and Molecular Medicine, Amrita School of Medical Sciences and Research Center (AIMS), Amrita Vishwa Vidyapeetham, Kochi 682041, Kerala, India. Electronic address:

Staphylococcus aureus (S. aureus) readily forms biofilms on prosthetic devices such as the pacemakers, heart valves, orthopaedic implants, and indwelling catheters. Its biofilms are recalcitrant to antibiotic therapy and pose a serious burden in the healthcare setting as they drastically increase the treatment cost and morbidity of the patient. Read More

View Article
November 2018
1 Read

Emulsan-based nanoparticles for in vivo drug delivery to tumors.

Biochem Biophys Res Commun 2018 Nov 27. Epub 2018 Nov 27.

Department of Medical Lifescience, College of Medicine, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul, 06591, Republic of Korea; Department of Biomedicine & Health Sciences, College of Medicine, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul, 06591, Republic of Korea; Catholic Photomedicine Research Institute, College of Medicine, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul, 06591, Republic of Korea. Electronic address:

Nanoparticles have been widely used as drug carriers, and finding new materials for them is important for efficient drug delivery. Herein, we developed a new nanoparticle using emulsan and flax seed oil. Emulsan is one of the representative biosurfactants obtained from Acinetobacter calcoaceticus RAG-1. Read More

View Article
November 2018

Mesoporous silica nanoparticles: a versatile platform for biomedical applications.

Recent Pat Drug Deliv Formul 2018 Dec 3. Epub 2018 Dec 3.

Laboratory of Nanomedicine, Institute of Life Sciences, Nalco Square, Bhubaneswar -751023, Odisha. India.

Background: Nanotechnology based drug delivery approach has emerged as a promising field, where different kinds of formulations are developed for therapeutic applications. Inflowing of nanomedicine developed through various biomaterials appears to be a game changer in the domain of pharmaceutical and biotechnological industries. Nanomedicines propose to overcome the major constraints of conventional medicine of low solubility and stability, and non-adequate pharmacokinetic profiles and side effects. Read More

View Article
December 2018

Development of photoactive Sweet-C for pancreatic cancer stellate cell therapy.

Nanomedicine (Lond) 2018 Dec 3. Epub 2018 Dec 3.

Department of Chemistry & Smalley-Curl Institute, Rice University, Houston, TX 77251, USA.

Aim: Glycoconjugated C derivatives are of particular interest as potential cancer targeting agents due to an upregulated metabolic glucose demand, especially in the case of pancreatic adenocarcinoma and its dense stroma, which is known to be driven by a subset of pancreatic stellate cells.

Materials & Methods: Herein, we describe the synthesis and biological characterization of a hexakis-glucosamine C derivative (termed 'Sweet-C').

Results: Synthesized fullerene derivative predominantly accumulates in the nucleus of pancreatic stellate cells; is inherently nontoxic up to concentrations of 1 mg/ml; and is photoactive when illuminated with blue and green light, allowing its use as a photodynamic therapy agent. Read More

View Article
December 2018

Effects of nanoparticles of hydroxy-aluminum phthalocyanine on markers of liver injury and glucose metabolism in diabetic mice.

Braz J Med Biol Res 2018 Dec 3;52(1):e7715. Epub 2018 Dec 3.

Departamento de Ciências Fisiológicas, Universidade Estadual de Maringá, Maringá, PR, Brasil.

Photodynamic therapy, by reducing pain and inflammation and promoting the proliferation of healthy cells, can be used to treat recurrent lesions, such as diabetic foot ulcers. Studies using the photosensitizer phthalocyanine, together with the nanostructured copolymeric matrix of Pluronic® and Carbopol® for the treatment of diabetic foot ulcers and leishmaniosis lesions, are showing promising outcomes. Despite their topical or subcutaneous administration, these molecules are absorbed and their systemic effects are unknown. Read More

View Article
December 2018

Amorphous Quantum Nanomaterials.

Adv Mater 2018 Dec 5:e1806993. Epub 2018 Dec 5.

Department of Materials Science and Engineering, Cornell University, Ithaca, NY, 14853, USA.

In quantum materials, macroscopic behavior is governed in nontrivial ways by quantum phenomena. This is usually achieved by exquisite control over atomic positions in crystalline solids. Here, it is demonstrated that the use of disordered glassy materials provides unique opportunities to tailor quantum material properties. Read More

View Article
December 2018
2 Reads

Inorganic Salts and Antimicrobial Photodynamic Therapy: Mechanistic Conundrums?

Molecules 2018 Dec 3;23(12). Epub 2018 Dec 3.

Laser Research Centre, Faculty of Health Science, University of Johannesburg, Johannesburg, Doornfontein 2028, South Africa.

We have recently discovered that the photodynamic action of many different photosensitizers (PSs) can be dramatically potentiated by addition of a solution containing a range of different inorganic salts. Most of these studies have centered around antimicrobial photodynamic inactivation that kills Gram-negative and Gram-positive bacteria in suspension. Addition of non-toxic water-soluble salts during illumination can kill up to six additional logs of bacterial cells (one million-fold improvement). Read More

View Article
December 2018

Enhancements of Cancer Cell Damage Efficiencies in Photothermal and Photodynamic Processes through Cell Perforation and Preheating with Surface Plasmon Resonance of Gold Nanoring.

Molecules 2018 Nov 30;23(12). Epub 2018 Nov 30.

Key Laboratory of Biomedical Information Engineering of Education Ministry, Institute of Biomedical Analytical Technology and Instrumentation, School of Life Science and Technology, Xi'an Jiaotong University, No.28, Xianning West Road, Xi'an 710049, Shanxi, China.

The methods of cell perforation and preheating are used for increasing cell uptake efficiencies of gold nanorings (NRIs), which have the localized surface plasmon resonance wavelength around 1064 nm, and photosensitizer, AlPcS, and hence enhancing the cell damage efficiency through the photothermal (PT) and photodynamic (PD) effects. The perforation and preheating effects are generated by illuminating a defocused 1064-nm femtosecond (fs) laser and a defocused 1064-nm continuous (cw) laser, respectively. Cell damage is produced by illuminating cell samples with a focused 1064-nm cw laser through the PT effect, a focused 1064-nm fs laser through both PT and PD effects, and a focused 660-nm cw laser through the PD effect. Read More

View Article
November 2018

Effect of Photodynamic Antibacterial Chemotherapy Combined with Antibiotics on Gram-Positive and Gram-Negative Bacteria.

Molecules 2018 Nov 30;23(12). Epub 2018 Nov 30.

Department of Chemical Engineering, Biotechnology and Materials, Ariel University, Ariel 4070000, Israel.

The well-known and rapidly growing phenomenon of bacterial resistance to antibiotics is caused by uncontrolled, excessive and inappropriate use of antibiotics. One of alternatives to antibiotics is Photodynamic Antibacterial Chemotherapy (PACT). In the present study, the effect of PACT using a photosensitizer Rose Bengal alone and in combination with antibiotics including methicillin and derivatives of sulfanilamide synthesized by us was tested against antibiotic-sensitive and antibiotic-resistant clinical isolates of Gram-positive and Gram-negative . Read More

View Article
November 2018

Functional Polymer Nanocarriers for Photodynamic Therapy.

Pharmaceuticals (Basel) 2018 Nov 30;11(4). Epub 2018 Nov 30.

CAS Key Laboratory of Soft Matter Chemistry, iChEM, and Department of Chemical Physics, University of Science and Technology of China, Hefei 230026, China.

Photodynamic therapy (PDT) is an appealing therapeutic modality in management of some solid tumors and other diseases for its minimal invasion and non-systemic toxicity. However, the hydrophobicity and non-selectivity of the photosensitizers, inherent serious hypoxia of tumor tissues and limited penetration depth of light restrict PDT further applications in clinic. Functional polymer nanoparticles can be used as a nanocarrier for accurate PDT. Read More

View Article
November 2018

Hypericin photodynamic activity in DPPC liposome. PART I: biomimetism of loading, location, interactions and thermodynamic properties.

J Photochem Photobiol B 2018 Nov 28;190:118-127. Epub 2018 Nov 28.

Departamento de Química, Universidade Estadual de Maringá, Av. Colombo, 5.790, 87020-900, Maringá, PR, Brazil. Electronic address:

Hypericin (Hyp) is a potential photosensitizer drug for Photodynamic Therapy (PDT). However, the high lipophilicity of Hyp prevents its preparation in water. To overcome the Hyp solubility problem, this study uses the liposomal vesicle of DPPC. Read More

View Article
November 2018

Regenerative therapy of peri-implantitis - Clinical and radiological documentation of 16 consecutive patients with a mean follow-up of three years.

J Oral Implantol 2018 Dec 4. Epub 2018 Dec 4.

2 University of Basel.

Sixteen patients with a diagnosis of peri-implantitis in 19 of 64 implants (29.7 %) were treated with an open flap approach according to a refined standardized surgical protocol. Treatment consisted of mechanical debridement, application of chemotherapeutical agents, and photodynamic therapy. Read More

View Article
December 2018

Nanoparticulate photosensitizer decorated with hyaluronic acid for photodynamic/photothermal cancer targeting therapy.

Nanomedicine (Lond) 2018 Dec 4. Epub 2018 Dec 4.

Department of Pharmacy, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou 310016, China.

Aim: A photomedicine consisting of a core for photothermal therapy, a photosensitizer for photodynamic therapy, and a cancer-targeting moiety was fabricated to improve photosensitizer selectivity and antitumor efficiency.

Materials & Methods: Hyaluronic acid-decorated polydopamine nanoparticles with conjugated chlorin e6 (HA-PDA-Ce6) were synthesized and characterized. Cell uptake, phototoxicity, penetration, distribution and therapeutic effects were evaluated. Read More

View Article
December 2018

An Insight Into the Potentiation Effect of Potassium Iodide on aPDT Efficacy.

Front Microbiol 2018 19;9:2665. Epub 2018 Nov 19.

Department of Biology and CESAM, University of Aveiro, Aveiro, Portugal.

Antimicrobial photodynamic therapy (aPDT) is gaining a special importance as an effective approach against multidrug-resistant strains responsible of fatal infections. The addition of potassium iodide (KI), a non-toxic salt, is recognized to increase the aPDT efficiency of some photosensitizers (PSs) on a broad-spectrum of microorganisms. As the reported cases only refer positive aPDT potentiation results, in this work we selected a broad range of porphyrinic and non-porphyrinic PSs in order to gain a more comprehensive knowledge about this aPDT potentiation by KI. Read More

View Article
November 2018
1 Read

Multifunctional nanotheranostic gold nanocages for photoacoustic imaging guided radio/photodynamic/photothermal synergistic therapy.

Acta Biomater 2018 Nov 27. Epub 2018 Nov 27.

CAS Key Laboratory of Nano-Bio Interface, Division of Nanobiomedicine, CAS Center for Excellence in Nanoscience, Suzhou Institute of Nano-Tech and Nano-bionics, Chinese Academy of Sciences, Suzhou 215123, PR China. Electronic address:

In this work, we developed a novel multifunctional nanoplatform based on hyaluronic acid modified Au nanocages (AuNCs-HA). The rational design of AuNCs-HA renders the nanoplatform three functionalities: (1) AuNCs-HA with excellent LSPR peak in the NIR region act as contrast agent for enhanced photoacoustic (PA) imaging and photothermal therapy (PTT); (2) the nanoplatform with high-energy rays (X-ray) absorption and auger electrons generation acts as a radiosensitizer for radiotherapy; (3) good photocatalytic property and large surface area make AuNCs-HA a photosensitive agent for photodynamic therapy (PDT). In vivo results demonstrated that AuNCs-HA presented excellent PA imaging performance after intravenous injection, which provided contour, size, and location information of the tumor. Read More

View Article
November 2018

Lipid-wrapped Upconversion Nanoconstruct /Photosensitizer Complex for Near-Infrared Light-mediated Photodynamic Therapy.

ACS Appl Mater Interfaces 2018 Nov 30. Epub 2018 Nov 30.

Photodynamic therapy (PDT) is a non-invasive medical technology that has been applied in cancer treatment where it is accessible by direct or endoscope-assisted light irradiation. To lower phototoxicity and increase tissue penetration depth of light, great effort has been focused on developing new sensitizers that can utilize red or near-infrared (NIR) light for the past decades. Lanthanide-doped upconversion nanoparticles (UCNPs) have a unique property to transduce NIR excitation light to UV-Vis emission efficiently. Read More

View Article
November 2018

Intralesional 5-Fluorouracil in the Treatment of Lower Leg Squamous Cell Carcinoma

J Drugs Dermatol 2018 Nov;17(11):1241-1243

Non-melanoma skin cancer (NMSC) is the most commonly diagnosed cancer in the United States.1,2 There are different treatment modalities for non-melanoma skin cancer, that include surgical excision, radiation therapy, cryotherapy, electrodessication and curettage, photodynamic therapy, and topical chemotherapy. Intralesional injection with 5-fluorouracil is a treatment modality that is not used often, perhaps due to not much research available to its effectiveness or established treatment recommendations. Read More

View Article
November 2018
3 Reads

Bacteria-Targeted Supramolecular Photosensitizer Delivery Vehicles for Photodynamic Ablation Against Biofilms.

Macromol Rapid Commun 2018 Nov 30:e1800763. Epub 2018 Nov 30.

MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, 310027, China.

Photodynamic therapy (PDT) is believed to be a potent method for biofilm treatments. However, undesired damage to normal cells may be caused due to the nonselective nature of PDT. Therefore, targeted PDT is preferred on one hand to enhance antimicrobial effects and on the other hand to reduce cytotoxicity to normal cells. Read More

View Article
November 2018

Integrating in situ formation of nanozymes with three-dimensional dendritic mesoporous silica nanospheres for hypoxia-overcoming photodynamic therapy.

Nanoscale 2018 Dec;10(48):22937-22945

Key Laboratory of Pesticide and Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, P. R. China.

Despite great progress in photodynamic therapy (PDT), the therapeutic effect is still limited by some points, such as tumor hypoxia, the short lifetime and the limited action region of 1O2. Herein, a special kind of three-dimensional dendritic mesoporous silica nanosphere (3D-dendritic MSN) was synthesized and used as a robust nanocarrier to deliver abundant hydrophobic photosensitizer chlorin e6 (Ce6) to the A549 lung cancer cells. To address the tumor hypoxia issue, the nanozyme Pt nanoparticles (Pt NPs) were immobilized onto the channels of 3D-dendritic MSNs to catalyze the conversion of intracellular H2O2 to oxygen. Read More

View Article
December 2018
3 Reads

Hypoxia- and singlet oxygen-responsive chemo-photodynamic Micelles featured with glutathione depletion and aldehyde production.

Biomater Sci 2018 Nov 30. Epub 2018 Nov 30.

School of Pharmaceutical Science & Technology, Tianjin Key Laboratory for Modern Drug Delivery & High Efficiency, and Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin University, Tianjin 300072, China.

Triggered drug release from anti-tumor nanomedicine is an efficient approach to address the dilemma of systemic nanocarrier stability and on-demand drug liberation in tumor sites. Combinational drug delivery has been a useful means to enhance antitumor efficacy and reduce adverse effects. We report a multifunctional micelle for dually hypoxia- and singlet oxygen-responsive integration of chemotherapy and photodynamic therapy. Read More

View Article
November 2018

A Combination of Visudyne and a Lipid-Anchored Liposomal Formulation of Benzoporphyrin Derivative Enhances Photodynamic Therapy Efficacy in a 3D Model for Ovarian Cancer.

Photochem Photobiol 2018 Nov 29. Epub 2018 Nov 29.

Wellman Center for Photomedicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.

A major objective in developing new treatment approaches for lethal tumors is to reduce toxicity to normal tissues while maintaining therapeutic efficacy. Photodynamic therapy (PDT) provides a mechanistically-distinct approach to treat tumors without the systemic toxicity of chemotherapy drugs. PDT involves the light-based activation of a small molecule, a photosensitizer (PS), to generate reactive molecular species (RMS) that are toxic to target tissue. Read More

View Article
November 2018
2 Reads