186 results match your criteria Photodynamic Therapy for the Dermatologist

Frequency of phototherapy for treating psoriasis: a systematic review.

Ital J Dermatol Venerol 2021 May 13. Epub 2021 May 13.

Department of Dermatology, Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan.

Introduction: Narrow band ultraviolet B (NB-UVB) and psoralen-ultraviolet A (PUVA) remain inexpensive and effective anti-psoriatic therapies adopted worldwide with different frequency protocols. We aimed to systematically assess the evidence on the effects of different frequency protocols of phototherapy in treating psoriasis.

Evidence Acquisition: We used the following terms, namely "photochemotherapy", "phototherapy", "psoriasis", "UVB", "UVA" and "ultraviolet therapy", to search the Cochrane Controlled Register of Trials, MEDLINE and Embase databases on August 1, 2019. Read More

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Skin Preparation for Photodynamic Therapy, Chemexfoliation, and Ablative Laser Resurfacing: a Systematic Literature Review.

Dermatol Surg 2021 Apr 30. Epub 2021 Apr 30.

Department of Dermatology, University of California, Irvine, Irvine, California; AboutSkin Dermatology and DermSurgery, Greenwood Village, Colorado.

Background: Photodynamic therapy, chemexfoliation, and ablative laser resurfacing are common practices for dermatologists, yet no formal protocols exist regarding preprocedural skin preparation.

Objective: To review and summarize the skin preparation protocols for photodynamic therapy, chemexfoliation, and ablative laser resurfacing available in the literature.

Methods: Data Sources A systematic review of English and non-English articles using the PubMed database was performed. Read More

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Long-term improvement on photoaging after ALA photodynamic therapy for actinic keratosis: A retrospective study.

Photodiagnosis Photodyn Ther 2021 Mar 8;33:102181. Epub 2021 Jan 8.

Institute of Photomedicine, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, China. Electronic address:

Background: 5-aminolevulinic acid photodynamic therapy (ALA-PDT) is not only the first-line treatment for actinic keratosis (AK), but also demonstrated to improve photoaging during AK field treatment. However, its long-term effect on photoaging remains elusive.

Objective: To evaluate the long-term improvement effect of ALA-PDT on photoaging. Read More

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Photodynamic therapy in dermatology: Beyond current indications.

Dermatol Ther 2020 11 28;33(6):e13997. Epub 2020 Jul 28.

Serviço de Dermatologia, Hospital de Santa Maria, Centro Hospitalar e Universitário de Lisboa Norte, Lisbon, Portugal.

Photodynamic therapy (PDT) has long been used in dermatology as a therapeutic strategy for several malignant and premalignant conditions. Currently, it is approved in Europe for the treatment of actinic keratosis, squamous cell carcinoma in situ, and some forms of basal cell carcinoma, with favorable clearance rates associated with satisfying aesthetic results. Nonetheless, in the past few years, PDT has also demonstrated efficacy in many other conditions, including inflammatory and infectious dermatoses. Read More

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November 2020

Erosive pustular dermatosis of the scalp: causes and treatments.

Int J Dermatol 2021 Jan 9;60(1):25-32. Epub 2020 Jun 9.

Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA.

Erosive pustular dermatosis of the scalp is a rare condition which primarily affects older women after local trauma and has historically been treated with topical steroids. As it is a rare entity and resembles other dermatologic conditions, it may easily be misdiagnosed. Identifying the causes and evaluating the efficacy of treatments of erosive pustular dermatosis of the scalp (EPDS) is of great importance to both avoid misdiagnosis and ensure optimal treatment of this rare condition. Read More

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January 2021

Efficacy of 595- and 1319-nm pulsed dye laser in the treatment of acne vulgaris: a narrative review.

J Cosmet Laser Ther 2020 Apr 9;22(3):111-114. Epub 2020 Jun 9.

Department of Dermatology, University Medical Center Mainz , Mainz, Germany.

Acne is one of the commonest problems of adolescence with almost half of the patients experiencing persistence into adulthood. Pulsed dye lasers (PDL) with wavelengths of 585 and 595 nm targeting hemoglobin have been used for the treatment of this condition and its sequelae. Recent introduction of PDL with a higher wavelength of 1319 nm has been reported to offer some benefit to acne patients. Read More

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Contrasting the efficacy of pulsed dye laser and photodynamic methylene blue nanoemulgel therapy in treating acne vulgaris.

Arch Dermatol Res 2021 Apr 24;313(3):173-180. Epub 2020 May 24.

Department of Dermatology, Electricity Hospital, Cairo, Egypt.

The treatment of acne remains a challenge for dermatologists. A variety of conventional therapies are available for acne treatment such as topical and systemic medications. Although many of these traditional acne treatments are effective, the wide-spread nature of the disease and its sometimes resistant nature delineate the need for alternative therapies. Read More

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Correlation between the hemoporfin-mediated photodynamic treatment response and the dermoscopy vascular pattern in patients with a port-wine stain: a prospective study.

J Eur Acad Dermatol Venereol 2020 Dec 5;34(12):2795-2801. Epub 2020 Jun 5.

Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology (HUST), Wuhan, China.

Background: Vascular targeted photodynamic therapy (PDT) is a novel and promising therapy for the treatment of port-wine stains (PWS). There has been little prior exploration to our knowledge of how the dermatological vascular pattern may predict the response to PDT.

Objectives: To analyse whether the vascular pattern classifications of PWS by dermoscopy can predict the efficacy of PDT. Read More

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December 2020

Topical tacalcitol as neoadjuvant for photodynamic therapy of acral actinic keratoses: An intra-patient randomized study.

Photodiagnosis Photodyn Ther 2020 Sep 8;31:101803. Epub 2020 May 8.

Department of Clinical and Experimental Medicine, Dermatology, University of Messina, Messina, 98125, Italy.

Background: photodynamic therapy (PDT) with topical 5-aminolevulinic acid (ALA) is a well described and widely practiced treatment for actinic keratoses (AKs) on the head and face. Less is known about its use for AKs on upper extremities, which can be challenging for the dermatologist. The aim of our study was to compare the combination of topical tacalcitol before 5-ALA-PDT vs conventional 5-ALA-PDT for acral AKs in a prospective, randomized, intra-individual clinical study. Read More

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September 2020

Therapeutic options for erosive pustular dermatosis of the scalp: a systematic review.

Br J Dermatol 2021 01 26;184(1):25-33. Epub 2020 May 26.

Department of Dermatology, Royal London Hospital, Barts Health NHS Trust, London, UK.

Background: Erosive pustular dermatosis of the scalp (EPDS) is a chronic condition characterized by erosive plaques and subsequent scarring alopecia as a result of local trauma or inflammation. A number of therapeutic approaches have been described in the literature but there is no consensus of opinion on optimal treatment of the disease.

Objectives: To provide evidence-based recommendations for topical and systemic treatment of adult patients with EPDS by performing a systematic review. Read More

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January 2021

[Therapeutic alternatives to surgical treatment of malignant eyelid tumors and their precursors].

Ophthalmologe 2020 May;117(5):478-483

Klinik für Dermatologie, Venerologie und Allergologie, Universitätsklinikum Leipzig AöR, Leipzig, Deutschland.

The treatment of choice for malignant eyelid tumors is surgical excision. If this is not feasible or undesirable, a number of alternative treatments are available. Possible systemic preparations are vismodegib and sonidegib for basal cell carcinoma as well as cetuximab and cemiplimab for squamous cell carcinoma. Read More

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Facial rejuvenation using photodynamic therapy with a novel preparation of ALA and hyaluronic acid in young adults.

Arch Dermatol Res 2020 Oct 14;312(8):567-573. Epub 2020 Feb 14.

Department of Dermatology, State University of New York, Downstate Health Sciences University, 450 Clarkson Ave, Box 46, Brooklyn, NY, USA.

Photodynamic therapy (PDT) is a well-established, non-invasive treatment modality that has shown desirable effects such as improvement of fine lines, dyspigmentation, and other signs of photodamage. Many patients seek to decrease, or reverse, effects of sun damage on the skin. Hyaluronic acid (HA), a naturally occurring glycosaminoglycan found in the body, has enormous potential to bind water which allows the skin to retain moisture and maintain elasticity. Read More

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October 2020

Daylight photodynamic therapy is an option for the treatment of actinic keratosis in patients with xeroderma pigmentosum in Africa.

Photodiagnosis Photodyn Ther 2020 Mar 2;29:101631. Epub 2020 Jan 2.

Regional Dermatology Training Center, Kilimanjaro Chirstian Medical Center, Moshi, Tanzania.

Background: Xeroderma pigmentosum (XP) is a very rare and severe genetic disorder with a DNA repair defect of ultraviolet (UV)-induced damage. Photodynamic therapy (PDT) has been successfully used in XP patients to treat actinic keratosis (AK) and daylight PDT (DL-PDT) has demonstrated similar efficacy to conventional PDT (C-PDT) for AK.

Objectives: To assess DL-PDT for the treatment of AK in patients with XP. Read More

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Erosive pustular dermatosis of the scalp: challenges and solutions.

Clin Cosmet Investig Dermatol 2019 12;12:691-698. Epub 2019 Sep 12.

Department of Experimental, Diagnostic and Specialty Medicine, Division of
 Dermatology, University of Bologna, Bologna, Italy.

Erosive pustular dermatosis of the scalp is a rare chronic inflammatory disorder defined. It usually affects elderly people and is characterized by extensive pustular lesions, erosions, and crusts located on the scalp. The pathogenesis of this disease is not completely understood, but a known predisposing factor is skin trauma. Read More

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September 2019

Photodynamic therapy for solid tumors: A review of the literature.

Photodermatol Photoimmunol Photomed 2019 Sep 18;35(5):295-303. Epub 2019 Jun 18.

Harvard Medical School, Boston, Massachusetts, USA.

Photodynamic therapy (PDT) utilizes a sensitizer agent and light to produce selective cell death. Dermatologists are familiar with PDT for the treatment of actinic keratoses and early nonmelanoma skin cancers, and recent studies have elucidated that PDT has resulted in improved morbidity and secondary outcomes for the treatment of various cancerous and precancerous solid tumors. Light source and dosimetry may be modified to selectively target tissue, and novel techniques such as fractionation, metronomic pulsation, continuous light delivery, and chemophototherapy are under investigation for further optimization of therapy. Read More

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September 2019

Management and clinical practice of multiple face and scalp actinic keratosis in France.

J Mark Access Health Policy 2019 14;7(1):1605787. Epub 2019 May 14.

Creativ-Ceutical, Paris, France.

: Actinic keratosis (AK) is characterized by the occurrence of thick and scaly skin areas caused by damage from ultraviolet radiation. The management of AK aims to reduce lesions and prevent their recurrence by regular monitoring. French guidelines, last updated in 2009, reflect European guidelines for the management of face and scalp AK. Read More

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Actinic Keratosis: Current Therapies and Insights Into New Treatments

J Drugs Dermatol 2019 May;18(5):s161-166.

Actinic keratosis (AK) develops on chronically sun-exposed skin and constitutes one of the most common diseases managed by dermatologists. The incidence of AKs continues to rise among aging as well as younger sun damaged populations worldwide, underscoring the importance of effective therapy options. Various treatments are available, including light-based therapies, topical therapies, and destructive therapies. Read More

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Prise en charge thérapeutique des kératoses actiniques: Treatment of actinic keratoses.

F Herms

Ann Dermatol Venereol 2019 May;146 Suppl 2:IIS22-IIS30

Service de dermatologie, CHU Saint-Louis, 1 avenue Claude-Vellefaux, 75010 Paris, France. Electronic address:

Dermatologists have many therapeutic options for the management of actinic keratoses (AK), in order to treat individual lesions or wider areas. Field cancerization is an area of sun-damaged skin, where visible and subclinical lesions co-exist, and is prone to the development of further AK lesions and sun-related skin cancers (SC). Treatments available are instrumental or medical. Read More

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Nonsurgical Options for the Treatment of Basal Cell Carcinoma.

Dermatol Pract Concept 2019 Apr 30;9(2):75-81. Epub 2019 Apr 30.

Department of Dermatology and Venereology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Objectives: The aim of this review article is to summarize the effectiveness, potential adverse events, and indications of the main nonsurgical treatment alternatives for basal cell carcinoma.

Methods: An extensive literature review was carried out. The most relevant articles were discussed and selected by the authors in order to provide a brief but evidence-based overview of the most common nonsurgical methods used for treating basal cell carcinoma. Read More

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Split-face study comparing conventional MAL photodynamic therapy in multiple actinic keratosis with complete time vs. half-time red light LED conventional illumination.

J Eur Acad Dermatol Venereol 2019 Aug 15;33(8):1529-1534. Epub 2019 Apr 15.

Dermatology Department, Hospital Ramón y Cajal, Madrid, Spain.

Background: Conventional photodynamic therapy (PDT) with methylaminolevulinic acid (MAL) and daylight PDT have demonstrated similar efficacy in the treatment of actinic keratosis (AK). The reason for the use of daylight is to reduce pain during illumination but daylight has the limitation of the weather conditions. The difference in the doses of red light applied between these two methods suggests that an intermediate dose with red light conventional illumination could be effective in PDT of AK. Read More

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An update on topical photodynamic therapy for clinical dermatologists.

J Dermatolog Treat 2019 Dec 19;30(8):732-744. Epub 2019 Jun 19.

Veterans Affairs Medical Center , Brooklyn , NY , USA.

Photodynamic therapy (PDT) involves the application of a topical photosensitizer, irradiation with light, and oxygen to produce cytotoxic reactive oxygen species that selectively destroy damaged cells while leaving normal skin intact. Topical PDT is a commonly used treatment for non-melanoma skin cancers (NMSCs) due to its excellent clearance rate and cosmetic outcomes. However, PDT is emerging as an off-label treatment modality for many dermatological conditions. Read More

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December 2019

Photodynamic therapy in dermatology.

Lasse R Braathen

G Ital Dermatol Venereol 2018 12;153(6):763

Dermatologist, Bern, Switzerland -

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December 2018

Adverse effects of topical photodynamic therapy: a consensus review and approach to management.

Br J Dermatol 2019 04 30;180(4):715-729. Epub 2018 Oct 30.

British Association of Dermatologists, London, U.K.

Background: Topical photodynamic therapy (PDT) is widely used to treat superficial nonmelanoma skin cancer and dysplasia, and is generally well tolerated. However, as with all treatments, adverse effects may occur and awareness may facilitate approaches to prevention and management.

Objectives: To review the available evidence relating to the adverse effects of topical PDT, to help inform recommendations in updated clinical guidelines produced by the British Association of Dermatologists and British Photodermatology Group, and the efficacy of preventative and therapeutic approaches. Read More

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Photodynamic and photobiological effects of light-emitting diode (LED) therapy in dermatological disease: an update.

Lasers Med Sci 2018 Sep 14;33(7):1431-1439. Epub 2018 Jul 14.

International Hair Research Foundation (IHRF), Milan, Italy.

Benefit deriving from the use of light is known since ancient time, but, only in the last decades of twentieth century, we witnessed the rapid expansion of knowledge and techniques. Light-emitted diode (LED)-based devices represent the emerging and safest tool for the treatment of many conditions such as skin inflammatory conditions, aging, and disorders linked to hair growth. The present work reviews the current knowledge about LED-based therapeutic approaches in different skin and hair disorders. Read More

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September 2018

Female Genital Itch.

Dermatol Clin 2018 Jul 26;36(3):225-243. Epub 2018 Apr 26.

Department of Dermatology, Wake Forest University School of Medicine, 4618 Country Club Road, Winston-Salem, NC 27104, USA. Electronic address:

Vulvar pruritus is a common complaint among young girls and women presenting to primary care physicians, gynecologists, and dermatologists. Female genital itch is especially disruptive because of its interference with sexual function and intimacy. Causes of vulvar itch are vast and may be inflammatory, environmental, neoplastic, or infectious, often with several causes coexisting simultaneously. Read More

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Conventional and combination topical photodynamic therapy for basal cell carcinoma: systematic review and meta-analysis.

Br J Dermatol 2018 12 9;179(6):1277-1296. Epub 2018 Sep 9.

Photobiology Unit, Dermatology Centre, The University of Manchester & Salford Royal NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, U.K.

Background: Topical photodynamic therapy (PDT) is an established treatment option for low-risk basal cell carcinoma (BCC).

Objectives: To compare efficacy, cosmesis and tolerability of PDT for BCC with alternative treatments.

Methods: MEDLINE, PubMed, Embase and CENTRAL databases were searched from inception until 1 September 2017. Read More

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December 2018

Photodynamic therapy with topical photosensitizers in mucosal and semimucosal areas: Review from a dermatologic perspective.

Photodiagnosis Photodyn Ther 2018 Sep 15;23:119-131. Epub 2018 Apr 15.

University of Florence School of Health Sciences, Department of Surgical and Translational Medicine, Section of Dermatology, P. Palagi Hospital, Viale Michelangelo 41, 50125, Florence, Italy.

Photodynamic Therapy is a procedure based on the interaction between a Photosensitizer, a light source with a specific wavelength and oxygen. The aim of this review is to provide a brief and updated analysis of scientific reports on the use of PDT with topical PS in the management of oncological, infectious, and inflammatory disorders involving mucosal and semimucosal areas, with a specific focus on diseases of dermatologic interest. Read More

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September 2018

Comparison of effectiveness and safety of excimer lamp vs topical calcipotriol-clobetasol propionate combination in the treatment of palmoplantar psoriasis.

Photodermatol Photoimmunol Photomed 2018 Jul 5;34(4):249-256. Epub 2018 Mar 5.

Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Background: Very few studies have assessed the efficacy of excimer in the treatment of palmoplantar psoriasis (PPP), and none has compared the excimer with calcipotriol-clobetasol propionate combination.

Purpose: To compare the effectiveness and safety of excimer lamp vs topical ointment containing calcipotriol (0.005% w/w) and clobetasol propionate (0. Read More

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