200 results match your criteria Photodynamic Therapy for the Dermatologist


Risk of cutaneous carcinogenesis with phototherapy in Indian subpopulation: A 10-year analysis and a review of literature.

Dermatol Ther 2022 Apr 24:e15536. Epub 2022 Apr 24.

Department of Dermatology, Kasturba Medical College Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India.

Phototherapy is an extremely effective and established therapeutic modality in a variety of dermatological disorders. However, there has been a constant concern with respect to its long-term usage as some of the studies have identified the risk of cutaneous malignancy associated with phototherapy. The carcinogenic potential of PUVA has been demonstrated in most US studies; however, the studies done on Asian and Arabian-African population have not corroborated similar findings, thus suggesting that the darker skin may confer protection against the development of cutaneous malignancy following phototherapy. Read More

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The Efficacy of Hematoporphyrin Monomethyl Ether Photodynamic Therapy in Adult Patients with Port-Wine Stains: A Retrospective Study.

Dermatol Ther (Heidelb) 2022 Apr 4;12(4):861-869. Epub 2022 Mar 4.

Department of Dermatology and Venereology, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, China.

Introduction: Hematoporphyrin monomethyl ether-photodynamic therapy (HMME-PDT) has been showing promising results in the treatment of port-wine stains (PWSs). We evaluated the clinical efficacy and treatment response of HMME-PDT in adult Chinese patients with PWSs.

Methods: A single-center retrospective study recruited adult PWS patients with negative HMME skin test results from December 2017 to May 2020. Read More

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Adverse reactions of ALA-PDT for the treatment of cutaneous diseases: A retrospective study.

Photodiagnosis Photodyn Ther 2022 Feb 24;38:102783. Epub 2022 Feb 24.

Institute of Photomedicine, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai 200092, China. Electronic address:

Background: 5-Aminolaevulinic acid photodynamic therapy (ALA-PDT) is an effective therapy for cutaneous diseases, such as precancers, superficial non melanoma skin cancers and certain inflammatory or viral conditions. However, the absence of a complete picture of adverse reactions limits the promotion of ALA-PDT.

Objective: To systemically investigate the detailed evidence of adverse reactions relating to ALA-PDT for skin diseases. Read More

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February 2022

A prospective study of adverse reactions of ALA-PDT for acne vulgaris.

Photodiagnosis Photodyn Ther 2022 Feb 14;38:102752. Epub 2022 Feb 14.

Institute of Photomedicine, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, 1278 Baode Road, Shanghai 200092, China. Electronic address:

Background: Acne vulgaris is a chronic inflammatory skin disease around pilosebaceous unit. 5-Aminolaevulinic acid photodynamic therapy (ALA-PDT) is an effective therapy for severe acne vulgaris. However, the lack of detailed information of adverse reactions limits the promotion of ALA-PDT in clinic. Read More

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February 2022

Sequential Use of CO Laser Prior to Nd:YAG and Dye Laser in the Management of Non-Facial Warts: A Retrospective Study.

Medicina (Kaunas) 2022 Jan 12;58(1). Epub 2022 Jan 12.

Department of Systems Medicine, Tor Vergata University, 00173 Rome, Italy.

: Warts are benign lesions of viral etiology characterized by a hyperkeratotic appearance tending to spread across the skin surface. Various treatments have been proposed to manage this condition, such as acids, imiquimod, photodynamic therapy, cryotherapy, and various lasers. In this paper, we describe a combination protocol using CO laser prior to Nd:YAG laser for lesions interesting the palmoplantar areas or dye laser for lesions on other skin surfaces in the management of non-facial warts resistant to traditional therapies. Read More

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January 2022

Clinical evaluation of a short illumination duration (1 hour) when performing photodynamic therapy of actinic keratosis using the Dermaris light source.

Authors:
M Creusot S Mordon

Photodiagnosis Photodyn Ther 2021 Dec 4;36:102618. Epub 2021 Nov 4.

Inserm U1026, University Bordeaux Segalen, Bordeaux, France. Electronic address:

Background: Photodynamic therapy (PDT) using daylight as the photoactivating light source (DL-PDT) is an effective treatment for actinic keratosis (AK). Among the artificial daylight sources, the Dermaris (Surgiris, Croix, France) is specially designed for SDL-PDT (simulated daylight PDT) of AK. To perform the PDT session, a long duration (2. Read More

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December 2021

A split-face clinical trial of conventional red-light photodynamic therapy versus daylight photodynamic therapy for acne vulgaris.

J Cosmet Dermatol 2021 Dec 1;20(12):3924-3930. Epub 2021 Aug 1.

Department of Dermatology, Tel Aviv Sourasky Medical Center, Affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Background: Photodynamic therapy (PDT) is considered an effective treatment for acne vulgaris. A significant drawback is pain during illumination. Daylight PDT (DL-PDT) is more tolerable. Read More

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December 2021

Photodynamic therapy of vitiligo: A pilot study.

Photodiagnosis Photodyn Ther 2021 Dec 25;36:102439. Epub 2021 Jul 25.

Skin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Shohada-e Tajrish Hospital, Shahrdari St, 1989934148, Tehran, Iran. Electronic address:

Background: Vitiligo is an acquired autoimmune skin disorder with depigmented macules and patches. There are several possible treatments for vitiligo, none of which could be considered as a definitive cure. Photodynamic therapy (PDT) is a novel treatment with controversial outcomes in vitiligo patients. Read More

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December 2021

Dermoscopic findings of genital keratotic lesions: Bowenoid papulosis, seborrheic keratosis, and condyloma acuminatum.

Photodiagnosis Photodyn Ther 2021 Dec 19;36:102448. Epub 2021 Jul 19.

Department of Dermatology, Kosin University College of Medicine, Busan, South Korea. Electronic address:

Dermatologists often encounter keratotic or warty lesions in the genital area. Establishing a clear diagnosis may seem challenging, particularly when the differential diagnosis includes bowenoid papulosis, seborrheic keratosis, and condyloma acuminatum. This study aimed to compare the dermoscopic features of bowenoid papulosis (BP), seborrheic keratosis, and condyloma acuminatum in the genital area. Read More

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December 2021

A clinical study of carbon dioxide lattice laser-assisted or microneedle-assisted 5-aminolevulinic acid-based photodynamic therapy for the treatment of hypertrophic acne scars.

Photodermatol Photoimmunol Photomed 2022 Jan 17;38(1):53-59. Epub 2021 Jul 17.

General Hospital of Air Force, PLA, Beijing, China.

Objective: To study the clinical efficacy, recurrence rate and safety of 5-aminolevulinic acid-based photodynamic therapy (ALA-PDT) combined with microneedle or CO2 lattice laser (CO2FL), in comparison with intrascar betamethasone injection in the treatment of hypertrophic acne scar.

Methods: Fifty-two patients with hypertrophic acne scars at the mandibular angle were enrolled and assigned to different therapy groups. Sixteen patients were treated with microneedle-assisted incorporation of ALA. Read More

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January 2022

Chinese guidelines on the clinical application of 5-aminolevulinic acid-based photodynamic therapy in dermatology (2021 edition).

Photodiagnosis Photodyn Ther 2021 Sep 12;35:102340. Epub 2021 May 12.

Institute of Photomedicine, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, China. Electronic address:

Photodynamic Therapy with 5-aminolevulinic acid (ALA-PDT) has been widely applied in the treatment of skin diseases in China. To further standardize, guide, and promote the clinical applications of ALA-PDT in dermatology, the Chinese Society of Dermatology, Chinese Association of Rehabilitation Dermatology, Photomedicine Therapeutic Equipment Group of Committee on Skin Disease, and Cosmetic Dermatology of China Association of Medical Equipment invited relevant experts engaged in ALA-PDT to revise and update the first edition of "Clinical application of 5-aminolevulinic acid-based photodynamic therapy: an expert consensus statement" and establish a more current edition, to provide an updated reference for Chinese dermatologists in clinical practice. In the guideline, the expert group reached consensus opinions on ALA-PDT with regard to mechanisms of action, therapeutic protocol, clinical applications, adverse reactions and countermeasures, precautions, care, and evaluation of efficacy. Read More

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September 2021

Frequency of phototherapy for treating psoriasis: a systematic review.

Ital J Dermatol Venerol 2021 05 13. Epub 2021 May 13.

Department of Dermatology, Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan -

Introduction: Narrow band ultraviolet B (NB-UVB) and psoralen-ultraviolet A (PUVA) remain inexpensive and effective anti-psoriatic therapies adopted worldwide with different frequency protocols. We aimed to systematically assess the evidence on the effects of different frequency protocols of phototherapy in treating psoriasis.

Evidence Acquisition: We used the following terms, namely "photochemotherapy", "phototherapy", "psoriasis", "UVB", "UVA" and "ultraviolet therapy", to search the Cochrane Controlled Register of Trials, MEDLINE and Embase databases on August 1, 2019. Read More

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Skin Preparation for Photodynamic Therapy, Chemexfoliation, and Ablative Laser Resurfacing: a Systematic Literature Review.

Dermatol Surg 2021 07;47(7):938-941

Department of Dermatology, University of California, Irvine, Irvine, California.

Background: Photodynamic therapy, chemexfoliation, and ablative laser resurfacing are common practices for dermatologists, yet no formal protocols exist regarding preprocedural skin preparation.

Objective: To review and summarize the skin preparation protocols for photodynamic therapy, chemexfoliation, and ablative laser resurfacing available in the literature.

Methods: Data Sources A systematic review of English and non-English articles using the PubMed database was performed. Read More

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Management of Difficult-to-Treat Warts: Traditional and New Approaches.

Authors:
Peter C Friedman

Am J Clin Dermatol 2021 May 11;22(3):379-394. Epub 2021 Jan 11.

The Skin Center Dermatology Group, 200 E Eckerson Road, New City, NY, 10956, USA.

Warts are regularly treated by dermatologists, and while many respond readily to first-line treatments, others may represent a therapeutic challenge. Large, deep, numerous, and extensive warts; treatment-resistant lesions with higher risk for side effects, such as hypopigmentation; or patients unable to tolerate or comply with our treatment regimen, may need alternative treatment options. In this work we review the characteristics of select modalities that should be considered for difficult-to-treat warts. Read More

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Long-term improvement on photoaging after ALA photodynamic therapy for actinic keratosis: A retrospective study.

Photodiagnosis Photodyn Ther 2021 Mar 8;33:102181. Epub 2021 Jan 8.

Institute of Photomedicine, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, China. Electronic address:

Background: 5-aminolevulinic acid photodynamic therapy (ALA-PDT) is not only the first-line treatment for actinic keratosis (AK), but also demonstrated to improve photoaging during AK field treatment. However, its long-term effect on photoaging remains elusive.

Objective: To evaluate the long-term improvement effect of ALA-PDT on photoaging. Read More

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Skin erythema and pigmentation: a review of optical assessment techniques.

Photodiagnosis Photodyn Ther 2021 Mar 1;33:102127. Epub 2020 Dec 1.

Engineering Physics, McMaster University, Ontario, Canada.

Background: Skin erythema may present due to many causes. One of the common causes is prolonged exposure to sun rays. Other than sun exposure, skin erythema is an accompanying sign of dermatological diseases such as acne, psoriasis, melasma, post inflammatory hyperpigmentation, fever, as well as exposure to specific electromagnetic wave bands. Read More

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Photodynamic therapy in dermatology: Beyond current indications.

Dermatol Ther 2020 11 28;33(6):e13997. Epub 2020 Jul 28.

Serviço de Dermatologia, Hospital de Santa Maria, Centro Hospitalar e Universitário de Lisboa Norte, Lisbon, Portugal.

Photodynamic therapy (PDT) has long been used in dermatology as a therapeutic strategy for several malignant and premalignant conditions. Currently, it is approved in Europe for the treatment of actinic keratosis, squamous cell carcinoma in situ, and some forms of basal cell carcinoma, with favorable clearance rates associated with satisfying aesthetic results. Nonetheless, in the past few years, PDT has also demonstrated efficacy in many other conditions, including inflammatory and infectious dermatoses. Read More

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November 2020

Erosive pustular dermatosis of the scalp: causes and treatments.

Int J Dermatol 2021 Jan 9;60(1):25-32. Epub 2020 Jun 9.

Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA.

Erosive pustular dermatosis of the scalp is a rare condition which primarily affects older women after local trauma and has historically been treated with topical steroids. As it is a rare entity and resembles other dermatologic conditions, it may easily be misdiagnosed. Identifying the causes and evaluating the efficacy of treatments of erosive pustular dermatosis of the scalp (EPDS) is of great importance to both avoid misdiagnosis and ensure optimal treatment of this rare condition. Read More

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January 2021

Efficacy of 595- and 1319-nm pulsed dye laser in the treatment of acne vulgaris: a narrative review.

J Cosmet Laser Ther 2020 Apr 9;22(3):111-114. Epub 2020 Jun 9.

Department of Dermatology, University Medical Center Mainz , Mainz, Germany.

Acne is one of the commonest problems of adolescence with almost half of the patients experiencing persistence into adulthood. Pulsed dye lasers (PDL) with wavelengths of 585 and 595 nm targeting hemoglobin have been used for the treatment of this condition and its sequelae. Recent introduction of PDL with a higher wavelength of 1319 nm has been reported to offer some benefit to acne patients. Read More

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Contrasting the efficacy of pulsed dye laser and photodynamic methylene blue nanoemulgel therapy in treating acne vulgaris.

Arch Dermatol Res 2021 Apr 24;313(3):173-180. Epub 2020 May 24.

Department of Dermatology, Electricity Hospital, Cairo, Egypt.

The treatment of acne remains a challenge for dermatologists. A variety of conventional therapies are available for acne treatment such as topical and systemic medications. Although many of these traditional acne treatments are effective, the wide-spread nature of the disease and its sometimes resistant nature delineate the need for alternative therapies. Read More

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Correlation between the hemoporfin-mediated photodynamic treatment response and the dermoscopy vascular pattern in patients with a port-wine stain: a prospective study.

J Eur Acad Dermatol Venereol 2020 Dec 5;34(12):2795-2801. Epub 2020 Jun 5.

Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology (HUST), Wuhan, China.

Background: Vascular targeted photodynamic therapy (PDT) is a novel and promising therapy for the treatment of port-wine stains (PWS). There has been little prior exploration to our knowledge of how the dermatological vascular pattern may predict the response to PDT.

Objectives: To analyse whether the vascular pattern classifications of PWS by dermoscopy can predict the efficacy of PDT. Read More

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December 2020

Topical tacalcitol as neoadjuvant for photodynamic therapy of acral actinic keratoses: An intra-patient randomized study.

Photodiagnosis Photodyn Ther 2020 Sep 8;31:101803. Epub 2020 May 8.

Department of Clinical and Experimental Medicine, Dermatology, University of Messina, Messina, 98125, Italy.

Background: photodynamic therapy (PDT) with topical 5-aminolevulinic acid (ALA) is a well described and widely practiced treatment for actinic keratoses (AKs) on the head and face. Less is known about its use for AKs on upper extremities, which can be challenging for the dermatologist. The aim of our study was to compare the combination of topical tacalcitol before 5-ALA-PDT vs conventional 5-ALA-PDT for acral AKs in a prospective, randomized, intra-individual clinical study. Read More

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September 2020

Ultraviolet imaging in dermatology.

Photodiagnosis Photodyn Ther 2020 Jun 18;30:101743. Epub 2020 Mar 18.

Department of Dermatology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, United States; Department of Cell Stress Biology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, United States. Electronic address:

Visual examination plays a central role in the diagnosis of skin diseases. Many dermatologists use magnification, or dermoscopy, to improve diagnostic certainty when assessing the skin under visible light. In addition to magnification, other technological advances have been made over the last century to improve our visual assessment of the skin. Read More

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Therapeutic options for erosive pustular dermatosis of the scalp: a systematic review.

Br J Dermatol 2021 01 26;184(1):25-33. Epub 2020 May 26.

Department of Dermatology, Royal London Hospital, Barts Health NHS Trust, London, UK.

Background: Erosive pustular dermatosis of the scalp (EPDS) is a chronic condition characterized by erosive plaques and subsequent scarring alopecia as a result of local trauma or inflammation. A number of therapeutic approaches have been described in the literature but there is no consensus of opinion on optimal treatment of the disease.

Objectives: To provide evidence-based recommendations for topical and systemic treatment of adult patients with EPDS by performing a systematic review. Read More

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January 2021

[Therapeutic alternatives to surgical treatment of malignant eyelid tumors and their precursors].

Ophthalmologe 2020 May;117(5):478-483

Klinik für Dermatologie, Venerologie und Allergologie, Universitätsklinikum Leipzig AöR, Leipzig, Deutschland.

The treatment of choice for malignant eyelid tumors is surgical excision. If this is not feasible or undesirable, a number of alternative treatments are available. Possible systemic preparations are vismodegib and sonidegib for basal cell carcinoma as well as cetuximab and cemiplimab for squamous cell carcinoma. Read More

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Facial rejuvenation using photodynamic therapy with a novel preparation of ALA and hyaluronic acid in young adults.

Arch Dermatol Res 2020 Oct 14;312(8):567-573. Epub 2020 Feb 14.

Department of Dermatology, State University of New York, Downstate Health Sciences University, 450 Clarkson Ave, Box 46, Brooklyn, NY, USA.

Photodynamic therapy (PDT) is a well-established, non-invasive treatment modality that has shown desirable effects such as improvement of fine lines, dyspigmentation, and other signs of photodamage. Many patients seek to decrease, or reverse, effects of sun damage on the skin. Hyaluronic acid (HA), a naturally occurring glycosaminoglycan found in the body, has enormous potential to bind water which allows the skin to retain moisture and maintain elasticity. Read More

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October 2020

Daylight photodynamic therapy is an option for the treatment of actinic keratosis in patients with xeroderma pigmentosum in Africa.

Photodiagnosis Photodyn Ther 2020 Mar 2;29:101631. Epub 2020 Jan 2.

Regional Dermatology Training Center, Kilimanjaro Chirstian Medical Center, Moshi, Tanzania.

Background: Xeroderma pigmentosum (XP) is a very rare and severe genetic disorder with a DNA repair defect of ultraviolet (UV)-induced damage. Photodynamic therapy (PDT) has been successfully used in XP patients to treat actinic keratosis (AK) and daylight PDT (DL-PDT) has demonstrated similar efficacy to conventional PDT (C-PDT) for AK.

Objectives: To assess DL-PDT for the treatment of AK in patients with XP. Read More

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Erosive pustular dermatosis of the scalp: challenges and solutions.

Clin Cosmet Investig Dermatol 2019 12;12:691-698. Epub 2019 Sep 12.

Department of Experimental, Diagnostic and Specialty Medicine, Division of
 Dermatology, University of Bologna, Bologna, Italy.

Erosive pustular dermatosis of the scalp is a rare chronic inflammatory disorder defined. It usually affects elderly people and is characterized by extensive pustular lesions, erosions, and crusts located on the scalp. The pathogenesis of this disease is not completely understood, but a known predisposing factor is skin trauma. Read More

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September 2019

Photodynamic therapy for solid tumors: A review of the literature.

Photodermatol Photoimmunol Photomed 2019 Sep 18;35(5):295-303. Epub 2019 Jun 18.

Harvard Medical School, Boston, Massachusetts, USA.

Photodynamic therapy (PDT) utilizes a sensitizer agent and light to produce selective cell death. Dermatologists are familiar with PDT for the treatment of actinic keratoses and early nonmelanoma skin cancers, and recent studies have elucidated that PDT has resulted in improved morbidity and secondary outcomes for the treatment of various cancerous and precancerous solid tumors. Light source and dosimetry may be modified to selectively target tissue, and novel techniques such as fractionation, metronomic pulsation, continuous light delivery, and chemophototherapy are under investigation for further optimization of therapy. Read More

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September 2019

Management and clinical practice of multiple face and scalp actinic keratosis in France.

J Mark Access Health Policy 2019 14;7(1):1605787. Epub 2019 May 14.

Creativ-Ceutical, Paris, France.

: Actinic keratosis (AK) is characterized by the occurrence of thick and scaly skin areas caused by damage from ultraviolet radiation. The management of AK aims to reduce lesions and prevent their recurrence by regular monitoring. French guidelines, last updated in 2009, reflect European guidelines for the management of face and scalp AK. Read More

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