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    157 results match your criteria Photodynamic Therapy for the Dermatologist

    1 OF 4

    Photodynamic therapy with topical photosensitizers in mucosal and semimucosal areas: review from a dermatologic perspective.
    Photodiagnosis Photodyn Ther 2018 Apr 15. Epub 2018 Apr 15.
    University of Florence School of Health Sciences, Department of Surgical and Translational Medicine, Section of Dermatology, P. Palagi Hospital, Viale Michelangelo 41, 50125, Florence, Italy.
    Photodynamic Therapy is a procedure based on the interaction between a Photo Sensitizer, a light source with a specific wavelength and oxygen. Aim of this Review is to provide a brief and updated analysis of scientific reports of the use of PDT with topical PS in the management of oncological, infectious, and inflammatory disorders involving mucosal and semimucosal areas, with a specific focus on diseases of dermatologic interest. Read More

    Photodynamic Therapy Activated by Intense Pulsed Light in the Treatment of Nonmelanoma Skin Cancer.
    Biomedicines 2018 Feb 7;6(1). Epub 2018 Feb 7.
    Skin Center, Dermo-Aesthetic Lasers Centers, 67051 Avezzano, Italy.
    Photodynamic therapy (PDT) with topical 5-aminolevulinic acid (ALA) or methyl aminolevulinate (MAL) has proven to be a highly effective conservative method for the treatment of actinic keratosis (AK), Bowen's disease (BD), and superficial basal cell carcinoma (sBCC). PDT is traditionally performed in association with broad-spectrum continuous-wave light sources, such as red or blue light. Recently, intense pulsed light (IPL) devices have been investigated as an alternative light source for PDT in the treatment of nonmelanoma skin cancers (NMSC). Read More

    Expert Consensus on Cosmetic Outcomes After Treatment of Actinic Keratosis.
    J Drugs Dermatol 2017 Mar;16(3):260-264

    Dermatologists treat actinic keratosis (AK) primarily because these lesions have the potential to progress to invasive squamous cell carcinoma. Patients, on the other hand, generally seek treatment to remove the lesions and achieve an improved appearance of their skin following treatment. In selecting a treatment option for AK, dermatologists should consider post-treatment cosmesis, because cosmetic outcomes differ across AK treatments. Read More

    The Two Faces of Fractionated Photodynamic Therapy: Increasing Efficacy With Light Fractionation or Adjuvant Use of Fractional Laser Technology.
    J Drugs Dermatol 2016 Nov;15(11):1324-1328
    "Fractionated photodynamic therapy (PDT)" is a new term being used by dermatologists to describe advances in PDT technology including fractionated light or the adjuvant use of fractional lasers. Although dermatologists have used PDT since the early 1990s for the treatment of photodamage and precancerous lesions, newer developments in technology have allowed for the treatment of non-melanoma skin cancers (NMSCs), in ammatory disorders, and even uses in the eld of anti-aging. Recent developments in fractionated light therapy have allowed for PDT with dark intervals and two-fold illumination schemes to increase cellular damage and apoptosis. Read More

    Long-Pulsed 1064-nm Nd:YAG Laser for the Treatment of Onychomycosis.
    Photomed Laser Surg 2017 Apr 30;35(4):213-216. Epub 2016 Dec 30.
    5 Department of Health Sciences, University of Catanzaro , Catanzaro, Italy .
    Objective: The aim of this study is to evaluate the efficacy of long-pulsed 1064-nm Nd:YAG laser in penetrating tissue and targeting the fungal overgrowth in the nail plate.

    Background: Onychomycosis is the most frequent nail disorder. Current treatments include oral and topical antifungal agents, photodynamic therapy, and surgical approaches such as mechanical, chemical, or surgical nail avulsion. Read More

    Treatment of moderate-to-severe atopic eczema in adults within the U.K.: results of a national survey of dermatologists.
    Br J Dermatol 2017 Jun 16;176(6):1617-1623. Epub 2017 Apr 16.
    Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, U.K.
    Background: Little is known about U.K. dermatologists' treatment approaches towards adult patients with recalcitrant moderate-to-severe atopic eczema. Read More

    Real-world approach to actinic keratosis management: practical treatment algorithm for office-based dermatology.
    J Dermatolog Treat 2017 Aug 13;28(5):431-442. Epub 2016 Nov 13.
    n Department of Dermatology , University of Modena and Reggio Emilia , Modena , Italy.
    Actinic keratosis (AK) is a chronic skin disease in which multiple clinical and subclinical lesions co-exist across large areas of sun-exposed skin, resulting in field cancerisation. Lesions require treatment because of their potential to transform into invasive squamous cell carcinoma. This article aims to provide office-based dermatologists and general practitioners with simple guidance on AK treatment in daily clinical practice to supplement existing evidence-based guidelines. Read More

    [The effect of drugs used in treatment of skin disorders on visual system].
    Pol Merkur Lekarski 2016 Apr;40(238):269-72
    Department of Dermatology, Venerology and Pediatric Dermatology, Medical University of Lublin, Poland.
    Drugs with side effects affecting vision are often used in the treatment of skin disorders. The study evaluated principal groups of medicines which may negatively influence vision and the eye itself. Antimalaric drugs may cause a number of disorders of vision and a diagnosed retinophaty is an absolute contraindication. Read More

    Adjunct use of optical coherence tomography increases the detection of recurrent basal cell carcinoma over clinical and dermoscopic examination alone.
    Photodiagnosis Photodyn Ther 2016 Jun 22;14:178-84. Epub 2016 Apr 22.
    Zaeland University Hospital, Department of Dermatology, Roskilde, Denmark.
    Background: Basal cell carcinoma (BCC) is a locally destructive form of skin cancer, mainly affecting Caucasians. In the last few years non-surgical treatments of BCC have become widely used and non-invasive methods for treatment monitoring and follow-up are therefore becoming increasingly warranted. The objective of this study was to investigate the utility of adjunct use of non-invasive optical coherence tomography (OCT) imaging for the detection of recurrent BCC over clinical and dermoscopic examination alone, in a real-world setting. Read More

    Photodynamic therapy for the treatment of different severity of acne: A systematic review.
    Photodiagnosis Photodyn Ther 2016 Jun 16;14:191-9. Epub 2016 Apr 16.
    Institute of Photomedicine, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, PR China, PR China. Electronic address:
    Introduction: Acne, a disease of pilosebaceous unit, is a common dermatologic disorder affecting about 80%-95% of people in both genders in adulthood. The available treatment options are conventional topical and/or oral medications, which are associated with adverse effects, partial response only, contraindications and reoccurrences. This necessitates the need for the introduction of novel treatment for improving acne lesions. Read More

    Intense pulsed light versus photodynamic therapy using liposomal methylene blue gel for the treatment of truncal acne vulgaris: a comparative randomized split body study.
    Arch Dermatol Res 2016 May 18;308(4):263-8. Epub 2016 Mar 18.
    Cairo Hospital for Dermatology and Venereology (Al-Haud Al-Marsoud), Cairo, Egypt.
    Acne vulgaris is an extremely common skin condition. It often leads to negative psychological consequences. Photodynamic therapy (PDT) using intense pulsed light has been introduced for effective treatment of acne. Read More

    Pyogenic granuloma in a patient with psoriasis successfully treated by 5-aminolevulinic acid photodynamic therapy: A case report.
    Exp Ther Med 2016 Jan 27;11(1):345-347. Epub 2015 Nov 27.
    Department of Dermatology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China.
    Pyogenic granuloma (PG) is an acquired benign vascular tumor of unknown etiology. In the present case report, PG was detected in a 49-year-old Chinese male patient with chronic plaque psoriasis. The psoriasis lesions on the finger where the granuloma had developed had been scratched excessively, as declared by the patient. Read More

    Daylight photodynamic therapy with MAL cream for large-scale photodamaged skin based on the concept of 'actinic field damage': recommendations of an international expert group.
    J Eur Acad Dermatol Venereol 2016 Jan 9;30(1):8-15. Epub 2015 Nov 9.
    Department of Dermatology, Molholm Hospital, Vejle, Denmark.
    Conventional PDT (c-PDT) is a widely used and approved non-invasive treatment for actinic keratosis (AK). Recent clinical, histological and immunohistochemical observations have shown that c-PDT with methyl aminolevulinate (MAL) may also partially reverse the signs of photodamage. However, pain and the need for special light source equipment are limiting factors for its use, especially in the treatment of large areas. Read More

    Daylight-mediated photodynamic therapy for actinic damage in Latin America: consensus recommendations.
    Photodermatol Photoimmunol Photomed 2016 Mar 9;32(2):81-7. Epub 2015 Dec 9.
    Santiago Medical Institute, Santiago, Chile.
    Although conventional photodynamic therapy (c-PDT) using methyl aminolevulinate cream (MAL) is effective for the treatment of grade I-II facial and scalp actinic keratosis (AK), it is associated with treatment-related pain for some patients. Daylight-mediated PDT (DL-PDT) has shown similar efficacy to c-PDT, was nearly painless, and was well tolerated. Overall, DL-PDT effectively treats AK and offers a simpler and better tolerated treatment option than c-PDT. Read More

    Georgian Med News 2015 Sep(246):46-53
    Tbilisi State Medical University; I. Javakhishvili Tbilisi State University, Georgia.
    Biological effect of a visible light depends on extend of its property to penetrate into the tissues: the greater is a wavelength the more is an effect of a radiation. An impact of a visible light on the skin is evident by wave and quantum effects. Quanta of a visible radiation carry more energy than infrared radiation, although an influence of such radiation on the skin is produced by the light spectrum on the boarder of the ultraviolet and the infrared rays and is manifested by thermal and chemical effects. Read More

    Actinic keratosis: a cross-sectional study of disease characteristics and treatment patterns in Danish dermatology clinics.
    Int J Dermatol 2016 Mar 14;55(3):309-16. Epub 2015 Aug 14.
    Department of Dermatology, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark.
    Objectives: The incidence of actinic keratosis (AK) is increasing, and several treatment options are available. The aim of this study was to describe clinical characteristics and treatment patterns in patients with AK treated by Danish dermatologists.

    Methods: A multicenter, non-interventional, cross-sectional study was conducted. Read More

    Imiquimod and Photodynamic Therapy Are Useful in the Treatment of Porokeratosis in Children with Bone Marrow Transplantation.
    Pediatr Dermatol 2015 Nov-Dec;32(6):e291-3. Epub 2015 Jul 29.
    Dermatology Service, Hospital San Jorge, Huesca, Spain.
    Porokeratosis is an uncommon disorder that affects keratinization. Immunosuppression may favor the development of porokeratotic lesions. Patients who receive allogenic transplants represent a therapeutic challenge to dermatologists. Read More

    Spanish-Portuguese consensus statement on use of daylight-mediated photodynamic therapy with methyl aminolevulinate in the treatment of actinic keratosis.
    Actas Dermosifiliogr 2015 Oct 24;106(8):623-31. Epub 2015 Jun 24.
    Servicio de Dermatología, Complejo Asistencial Universitario de León, León, España.
    Introduction: Daylight-mediated photodynamic therapy (PDT) is a new type of PDT that is as effective as conventional PDT in grade 1 and 2 actinic keratosis but with fewer adverse effects, resulting in greater efficiency. The climatic conditions in the Iberian Peninsula require an appropriately adapted consensus protocol.

    Objective: We describe a protocol for the treatment of grade 1 and 2 actinic keratosis with daylight-mediated PDT and methyl aminolevulinate (MAL) adapted to the epidemiological and clinical characteristics of Spanish and Portuguese patients and the climatic conditions of both countries. Read More

    Treatment of basal cell carcinoma in Scandinavia: evidence or eminence based?
    Int J Dermatol 2015 Sep 6;54(9):1030-3. Epub 2015 Feb 6.
    Department of Dermatology, Karlskoga Hospital, Karlskoga, Sweden.
    Background: Basal cell carcinoma (BCC) is a locally destructive form of skin cancer, mainly affecting Caucasians. There are multiple treatment options for BCC, with excisional surgery being most widely used. Choice of treatment may be dependent on clinical guidelines, local therapeutic traditions, and/or personal experience. Read More

    Practical approach to the use of daylight photodynamic therapy with topical methyl aminolevulinate for actinic keratosis: a European consensus.
    J Eur Acad Dermatol Venereol 2015 Sep 28;29(9):1718-23. Epub 2015 Jan 28.
    Dermatology, Bern, Im Holenacker 16, CH-3063, Ittigen, Switzerland.
    Introduction: Daylight-mediated photodynamic therapy has been shown to be an effective therapy for actinic keratoses (AKs) and a simple and tolerable treatment procedure in three randomized Scandinavian studies and two recent Phase III randomized controlled studies in Australia and Europe.

    Objectives: To establish consensus recommendations for the use of daylight photodynamic therapy (DL-PDT) using topical methyl aminolaevulinate (MAL) in European patients with AKs.

    Methods: The DL-PDT consensus recommendations were developed on behalf of the European Society for Photodynamic Therapy in Dermatology and comprised of 10 dermatologists from different European countries with experience in how to treat AK patients with PDT. Read More

    Phototherapy for atopic dermatitis.
    Indian J Dermatol Venereol Leprol 2015 Jan-Feb;81(1):10-5
    Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
    Background: The aim of these guidelines is to review the available published literature regarding the effectiveness of phototherapy and photochemotherapy in atopic dermatitis and put forward recommendations regarding their use in atopic dermatitis.

    Materials And Methods: A literature search was performed to collect data from PubMed, EMBASE, and the Cochrane Library published till March 2014. Keywords used were "phototherapy", "photochemotherapy", "NB-UVB", "BBUVB", "PUVA", "UVA1", "atopic dermatitis", and "atopic eczema". Read More

    Field cancerization: from molecular basis to selective field-directed management of actinic keratosis.
    Curr Probl Dermatol 2015 18;46:115-21. Epub 2014 Dec 18.
    Hautzentrum Köln (Cologne Dermatology), Cologne, Germany.
    The incidence of non-melanoma skin cancer (NMSC), including actinic keratosis (AK), squamous cell carcinoma (SCC), Bowen's Disease (BD) and basal cell carcinoma (BCC), is increasing. UVA and UVB radiation lead to genetic alterations in keratinocytes, which eventually result in skin cancer. In the concept of field cancerization of the skin, genetically altered keratinocytes accumulate over an area exposed to UV radiation. Read More

    Lmax and imiquimod 3.75% in daily clinical practice.
    J Eur Acad Dermatol Venereol 2015 Jan;29 Suppl 1:15-8
    Department of Dermatology, Monklands Hospital, Airdrie, Lanarkshire, UK.
    Background: Lmax, the maximum lesion count during treatment, is a new concept for evaluating the efficacy of field-directed treatments for actinic keratosis (AK) against clinical and subclinical lesions. Imiquimod 3.75% is a field-directed AK treatment, which can detect and clear clinical and subclinical lesions across an entire sun-exposed field such as the full face or balding scalp. Read More

    Photochemotherapy (PUVA) in psoriasis and vitiligo.
    Indian J Dermatol Venereol Leprol 2014 Nov-Dec;80(6):497-504
    Department of Dermatology and Venereology, Kasturba Medical College, Manipal University, Manipal, India.
    Phototherapy with photochemotherapy (PUVA) is a well-known and well-studied modality for the treatment of psoriasis, which involves systemic or topical administration of chemicals known as psoralens and administration of ultraviolet light in increasing dosages after requisite time gap. PUVA is also used in the treatment of widespread vitiligo with moderately good results, though it is being surpassed by ultraviolet B (UVB), which is equally or slightly more efficacious with fewer side effects. PUVA induces repigmentation by varying mechanisms such as stimulation of melanogenesis, immunomodulation and activation of growth factors, though the exact mechanism is still speculative. Read More

    Photodynamic Therapy with 5% δ-Aminolevulinic Acid is Safe and Effective Treatment of Acne Vulgaris in Japanese Patients.
    Laser Ther 2014 Jul;23(2):115-20
    Department of Dermatology, Nippon Medical School, Japan.
    Background And Aims: Photodynamic therapy with aminolevulinic acid (ALA-PDT) is effective therapy for acne vulgaris; however, relatively strong side effects limit its wide usage. We have previously demonstrated that ALA-induced protoporphyrin IX distribution with lower concentrations and shorter contact time of ALA resulted in focused damage in sebaceous glands in vivo. We have formulated a protocol for ALA-PDT using 5% ALA with 2 hours contact time. Read More

    [Lichen sclerosus--clinical and therapeutic aspects].
    Akush Ginekol (Sofiia) 2014 ;53(1):35-9
    Lichen sclerosus (LS) is a lymphocyte-mediated inflammatory dermatosis with a characteristic location (85-98%) in the anogenital region. The authors point out the main features in the epidemiology and clinical presentation of the disease and the possible approach to neoplastic development. Expanded differential diagnosis of LS sparked not only dermatologists but also gynecologists, urologists and GPs. Read More

    Photodynamic therapy using a new formulation of 5-aminolevulinic acid for wrinkles in Asian skin: A randomized controlled split face study.
    J Dermatolog Treat 2015 Jun 9;26(3):246-51. Epub 2014 Jul 9.
    Department of Dermatology, Samsung Medical Center, Sungkyunkwan University School of Medicine , Seoul , Korea.
    Background: Photodynamic therapy (PDT) with intense pulsed light (IPL) was proven effective for photorejuvenation. Recently, a new formulation of 0.5% 5-aminolevulinic acid (ALA) liposomal spray has been available. Read More

    Physicians' concerns towards prescription adherence and treatment effectiveness in the clinical management of actinic keratosis.
    G Ital Dermatol Venereol 2014 Apr;149(2):193-8
    Department of Dermatology University of L'Aquila, L'Aquila, Italy -
    Aim: We report concerns toward prescription adherence and treatment effectiveness in the clinical management of actinic keratosis (AK) in Italy.

    Methods: We carried out a cross-sectional web-based survey among Italian dermatologists across Italy. Physicians were asked to answer a self-administered questionnaire about their concerns around AK therapy and barriers to patients' adherence. Read More

    Physicians' opinions and clinical practice patterns for actinic keratosis management in Italy.
    G Ital Dermatol Venereol 2014 Apr;149(2):185-92
    Department of General Oncological Dermatology L'Aquila University, L'Aquila, Italy -
    Aim: We report dermatologists' opinions and clinical practice patterns about clinical factors driving decision making in the management of actinic keratosis (AK) in Italy.

    Methods: We carried out a cross-sectional survey among 33 Italian dermatologists. Physicians were asked to report their management choices in consecutive patients with AK seen at their practice within 2 weeks since study initiation. Read More

    Update of the European guidelines for basal cell carcinoma management.
    Eur J Dermatol 2014 May-Jun;24(3):312-29
    Département de Dermatologie, Hôpital Saint-Louis, 1, avenue Claude Vellefaux, 75017 Paris, France.
    Background: European guidelines for the management of basal cell carcinoma (BCC) prepared by the former BCC subcommittee of the Guidelines Committee of the European Dermatology Forum (EDF) were published in 2006.

    Objectives: To present updated guidelines that include consensual expert definitions on various BCC types, prognosis and risk factors for BCC as well as review recommendations for diagnosis and treatment reflecting current published evidence.

    Methods: These guidelines (S1 type) were prepared by the new BCC subgroup of the European Dermatology Forum (EDF)'s Guidelines Committee through extensive literature review (up to 2012) and expert experience; they were extensively discussed within the EDF subcommittee and approved by peer reviewers of the EDF. Read More

    Reliability of solar keratosis clinical diagnosis: A prospective study.
    Australas J Dermatol 2015 May 17;56(2):e49-52. Epub 2014 Mar 17.
    Department of Skin and Venereal Diseases, Lithuanian University of Health Sciences, Medical Academy, Kaunas, Lithuania.
    Usually solar keratoses (SK) are diagnosed clinically. However other diseases may clinically present as erythematous macules, papules or patches on sun-exposed areas; therefore the histopathology remains the gold standard diagnostic tool. Our study, which assessed the efficacy of photodynamic therapy (PDT), showed that one in 20 clinically diagnosed SK lesions grade I-II identified by board-certified dermatologists were rosacea and only one in 40 were malignant lesions. Read More

    Perioral dermatitis: a review of the condition with special attention to treatment options.
    Am J Clin Dermatol 2014 Apr;15(2):101-13
    Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Sor Kor 11th Building, Pathumwan, Bangkok, Thailand,
    Perioral dermatitis is a common acneiform facial eruption found in both adults and children. Its variants are periorificial and granulomatous periorificial dermatitis. The etiology of perioral dermatitis remains unknown; however, topical corticosteroid use on the face commonly precedes the manifestation of this condition. Read More

    Management of actinic keratosis: a practical report and treatment algorithm from AKTeam™ expert clinicians.
    J Eur Acad Dermatol Venereol 2014 Sep 11;28(9):1141-9. Epub 2014 Mar 11.
    Department of Dermato cancerology, University Hospital Hotel Dieu, Nantes, France.
    Background: Actinic keratoses (AK) are common photo-induced cutaneous lesions that may progress to invasive squamous-cell carcinoma and serve as a risk marker for skin cancer. Although numerous studies present the various therapeutic options for AK, publications that can be used to pragmatically guide dermatologists in their daily practice are limited. National and international guidelines have been published, however, they are based on clinical trials with highly selected patient populations and do not always capture the range of patients seen in everyday practice. Read More

    Drug-induced photoallergic and phototoxic reactions - an update.
    Expert Opin Drug Saf 2014 Mar;13(3):321-40
    New York Presbyterian Hospital, Weill Cornell Medical College, Department of Dermatology , New York, NY 10021 , USA
    Introduction: Photoallergic and phototoxic medications continue to be an important concern for dermatologists. In the last 5 years, the list of phototoxic and photoallergic medications has expanded, as well as the testing tools used to screen for potential allergy. Currently available testing methods include the photoprick, photoscratch and illuminated intracutaneous tests. Read More

    Lasers and laser-like devices: part two.
    Australas J Dermatol 2014 Feb 11;55(1):1-14. Epub 2013 Nov 11.
    Department of Dermatology, Royal Prince Alfred Hospital, Camperdown, New South Wales; University of Sydney, Camperdown, New South Wales.
    Part two of this review series evaluates the use of lasers and laser-like devices in dermatology based on published evidence and the collective experience of the senior authors. Dermatologists can laser-treat a wide range of dermatoses, including vascular, pigmentary, textural, benign proliferative and premalignant conditions. Some of these conditions include vascular malformation, haemangioma, facial telangiectases, café-au-lait macules, naevi of Ota, lentigines, acne scarring, rhytides, rhinophyma and miscellaneous skin lesions. Read More

    Prolonged adverse events following photodynamic therapy: regulatory implications.
    J Drugs Dermatol 2014 Jan;13(1):62-6
    Objective: To determine whether field photodynamic therapy (PDT) of actinic keratoses (AKs) using a novel preparation of 5-aminolevulonic acid (ALA) would result in fewer subsequent invasive skin cancers developing on the face.

    Design: A prospective multi-center randomized controlled trial. The protocol was approved by the Bond University Human Research Ethics Committee in accord with the TGA's Clinical Trial Notification Scheme. Read More

    Psoralen-ultraviolet A treatment with Psoralen-ultraviolet B therapy in the treatment of psoriasis.
    Pak J Med Sci 2013 May;29(3):758-61
    Dr. Najam-us-Saher, Consultant Dermatologist, Zainab Panjwani Memorial Hospital, Karachi, Pakistan.
    Objective: To compare the conventional psoralen-ultraviolet A treatment with psoralen-ultraviolet B therapy in the treatment of psoriasis.

    Methodology: We studied 50 patients of plaque type psoriasis who were selected to receive either conventional psoralen-ultraviolet A or psoralen-ultraviolet B treatment.

    Results: There was no significant difference between the two treatment groups in the number of patients whose skin cleared of psoriasis or the number of exposures required for clearance. Read More

    Pharmacotherapeutic management of actinic keratosis: focus on newer topical agents.
    Am J Clin Dermatol 2013 Aug;14(4):273-7
    Division of Dermatology, University of California-Habor Medical Center, Torrance, CA, USA.
    Actinic (solar) keratoses (AK) have the potential for malignant transformation and are the second most common diagnosis in dermatologic practices. No well-established clinical criteria are available to determine which AK are more likely to undergo malignant transformation; therefore, many dermatologists utilize field-directed approaches to treat all visible and subclinical AK on an affected skin surface. Current topical therapeutic agents require lengthy treatment regimens and are less well tolerated than many newer and investigational agents. Read More

    Consensus recommendations for the treatment of basal cell carcinomas in Gorlin syndrome with topical methylaminolaevulinate-photodynamic therapy.
    J Eur Acad Dermatol Venereol 2014 May 13;28(5):626-32. Epub 2013 Apr 13.
    Hôpital Saint-Louis, Paris, France.
    Background: Patients with Gorlin syndrome develop multiple basal cell carcinomas (BCC), for which treatment is often difficult. Methylaminolevulinate-photodynamic therapy (MAL-PDT) is approved for the treatment of superficial and nodular BCCs in Canada and several European countries.

    Objectives: To establish consensus recommendations for the use of MAL-PDT in patients with Gorlin syndrome. Read More

    Combined carbon dioxide laser with photodynamic therapy for nodular and superficial basal cell carcinoma.
    Ann Plast Surg 2014 Nov;73(5):552-8
    From the *Welsh Regional Burns and Plastic Surgery Unit, Morriston Hospital, Swansea; and †Mersey Regional Burns and Plastic Surgery Unit, Whiston Hospital, Merseyside, UK.
    Background: Basal cell carcinomas (BCCs) are often seen by general practitioners, plastic surgeons, and dermatologists in the outpatient setting. Photodynamic therapy (PDT) and CO2 laser when used as monotherapy have been successfully used to treat small BCC, with greatest success in the superficial histological subtype but have limitations compared to surgical excision due to a limited depth of penetration of PDT (2 mm absorption) limiting efficacy. We describe our experience of dual-modality treatment improving efficacy, cosmetic outcomes, and minimizing recurrence. Read More

    The France-PDT study: a national prospective observational cohort survey on the use of methyl-aminolevulinate photodynamic therapy in France, with up to 6-month follow-up.
    Eur J Dermatol 2013 Jan-Feb;23(1):68-76
    Dermatology clinic, 7 rue Coypel, 75013 Paris, France.
    Background: The efficacy and safety of MAL-PDT have been shown in actinic keratoses (AK), basal cell carcinoma (BCC), and Bowen's disease (BD).

    Objectives: To appraise the current use of MAL-PDT in France.

    Methods: National prospective cohort survey, including 583 patients treated for the first time with MAL-PDT. Read More

    Treatment of sebaceous hyperplasia with a novel 1,720-nm laser.
    J Drugs Dermatol 2012 Nov;11(11):1323-6
    Scripps Clinic Laser and Cosmetic Dermatology, San Diego, CA, USA.
    Background: Sebaceous hyperplasia is a common benign proliferation of sebaceous glands. Multiple treatment methods have been applied in the past, including electrodessication, ablative and visible light lasers, applications of acids, and photodynamic therapy. Often, however, only the superficial component of the lesion is treated, leading to rapid recurrence. Read More

    Pharmacotherapy of actinic keratosis: an update.
    Expert Opin Pharmacother 2012 Sep;13(13):1847-71
    Center for Clinical and Cosmetic Research, Skin and Cancer Associates, Aventura, FL 33180, USA.
    Introduction: Actinic keratosis (AK) represents the initial intraepidermal manifestation of abnormal keratinocyte proliferation, with the potential of progression to squamous cell carcinoma (SCC). Few visible AKs lead to the use of lesion-directed treatments, including ablative and/or surgical procedures. Multiple and/or the suspicion of subclinical (non-visible) AKs lead to the use of field-directed therapies, including topical and ablative treatments. Read More

    High discordance between punch biopsy and excision in establishing basal cell carcinoma subtype: analysis of 500 cases.
    J Eur Acad Dermatol Venereol 2013 Aug 3;27(8):985-9. Epub 2012 Jul 3.
    Department of Dermatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.
    Background: Basal cell carcinoma (BCC) is the most frequently occurring cancer in humans. Worldwide incidences rise about 10% each year, increasing the burden on dermatologists, general practitioners and pathologists as well as increasing costs for the health care system. Increasingly non-surgical treatment options are used in the treatment of BCC, without histological confirmation of BCC subtype, potentially resulting in under-treatment. Read More

    The horizon for treating cutaneous vascular lesions.
    Semin Cutan Med Surg 2012 Jun;31(2):98-104
    Department of Dermatology, University of California, Irvine, CA 92612, USA.
    Dermatologists encounter a wide range of cutaneous vascular lesions, including infantile hemangiomas, port-wine stain birthmarks, arteriovenous malformations, venous malformations, Kaposi sarcomas, angiosarcomas, and angiofibromas. Current treatment modalities to reduce these lesions include topical and/or intralesional steroids, laser therapy, surgical resection, and endovascular therapy. However, each method has limitations owing to recurrence, comorbidities, toxicity, or lesion location. Read More

    Efficacy of psoralen UV-A therapy vs. narrowband UV-B therapy in chronic plaque psoriasis: a systematic literature review.
    J Eur Acad Dermatol Venereol 2012 May;26 Suppl 3:11-21
    INSERM CRO2 and Dermatology Department, Aix-Marseille Univ, UMR 911, Timone Hospital, Marseille, France.
    Background: Oral 8-methoxypsoralen-UV-A (PUVA) and Narrowband UV-B (NB-UVB or UVB TL-01) are well established treatments for chronic plaque psoriasis but there is limited evidence regarding their respective efficacy.

    Objectives: To prepare for evidence-based recommendations concerning the practical use of oral 8-methoxypsoralen-UV-A and Narrowband UV-B in psoriasis, a systematic review to assess respective response rates, remission duration and predictive factors of efficacy was performed.

    Methods: A systematic search was carried out in PubMed, Cochrane and Embase databases, using the key words 'Psoriasis', 'UVB therapy', 'UVA therapy' for the period from 1980 to December 2010. Read More

    Management of non-melanoma skin cancer in immunocompromised solid organ transplant recipients.
    Curr Treat Options Oncol 2012 Sep;13(3):354-76
    Transplant Dermatology Clinic, Department of Dermatology, Yale School of Medicine, New Haven, CT 06520-8059, USA.
    The management of non-melanoma skin cancers (NMSCs) in solid organ transplant recipients (OTRs) presents a variety of clinical challenges for physicians. OTRs are at a 65-fold increased risk for developing cutaneous squamous cell carcinomas (SCC), the most common NMSC that develops after transplantation. Risk factors contributing to the development of NMSCs in OTRs include a past medical history of any previous skin cancer, a personal history of significant sun exposure and a fair skin complexion or phototype. Read More

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