1,306 results match your criteria Photodiagnosis and Photodynamic Therapy [Journal]


Successful treatment of chromoblastomycosis using ALA-PDT in a patient with leukopenia.

Photodiagnosis Photodyn Ther 2019 Feb 12. Epub 2019 Feb 12.

Department of Dermatology, Nanfang Hospital, Southern Medical University, 1838 North Avenue, Guangzhou 510515, China. Electronic address:

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http://dx.doi.org/10.1016/j.pdpdt.2019.02.013DOI Listing
February 2019

Folate-directed zinc (II) phthalocyanine loaded polymeric micelles engineered to generate reactive oxygen species for efficacious photodynamic therapy of cancers.

Photodiagnosis Photodyn Ther 2019 Feb 12. Epub 2019 Feb 12.

Department of Organic and Pharmaceutical Technology, Faculty of Chemistry, Wroclaw University of Science and Technology, Wybrzeże Wyspiańskiego 27, 50-370, Wroclaw, Poland. Electronic address:

Targeted and effective drug transport is becoming an attractive option in cancer therapy since it can improve drug efficacy and reduce drugs' side effects in normal tissues. In addition to using specific surface ligand molecules, the selective drug delivery can be accomplished via enhanced permeability and retention effect. Therefore, in our studies, we entrapped zinc (II) phthalocyanine (ZnPc) - a second generation photosensitizer - in folate-functionalized micelles of the biocompatible, FDA-approved for biomedical application diblock copolymer methoxypoly(ethylene oxide)-b-poly(L-lactide) (mPEG-b-PLLA) and its derivative with folate (FA) attached to the end of PEG chain (FA-PEG-b-PLLA). Read More

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http://dx.doi.org/10.1016/j.pdpdt.2019.02.014DOI Listing
February 2019

The use of the Z-scan technique for the determination of biochemical parameters in children with solid tumors or leukemias supplemented or not with selenium.

Photodiagnosis Photodyn Ther 2019 Feb 12. Epub 2019 Feb 12.

Universidade Federal de São Paulo, Instituto de Ciências Ambientais, Químicas e Farmacêuticas. Rua Prof. Arthur Riedel, 275, Jardim Eldorado, 09972-270, Diadema, SP, Brasil; Faculdade de Medicina do ABC, Laboratório de Analises Clínicas. Av. Principe de Gales, 821, 09060-650, Santo André, SP, Brasil.

Cancer is a disease that affects cell metabolism causing an imbalance in the health of the patient. On the other hand, malnutrition, presented by oncological patients, is caused by both the disease and its treatment. Some serum biochemical parameters cannot be determined by the traditional method of laboratory blood analysis (spectrophotometry). Read More

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http://dx.doi.org/10.1016/j.pdpdt.2019.02.012DOI Listing
February 2019

Scope of antimicrobial photodynamic therapy in Orthodontics and related research: A review.

Photodiagnosis Photodyn Ther 2019 Feb 9. Epub 2019 Feb 9.

Department of Periodontology, Stony Brook University, Stony Brook, NY, USA; Laboratory for Periodontal-, Implant-, Phototherapy (LA-PIP), School of Dental Medicine, Stony Brook University, Stony Brook, NY, USA.

Background: The aim of the present study was to comprehensively review indexed literature regarding the potential role of antimicrobial photodynamic therapy (aPDT) in Orthodontics.

Methods: Indexed databases were searched up to and including January 2019 using the following key words: (a) antimicrobial photodynamic therapy; (b) antimicrobial photodynamic chemotherapy; (c) orthodontic; and (d) orthodontics. Original (clinical and experimental) studies, case-reports, and case-series were included. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15721000183043
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http://dx.doi.org/10.1016/j.pdpdt.2019.02.011DOI Listing
February 2019
3 Reads

Adjunctive antimicrobial photodynamic therapy to conventional chemo-mechanical debridement of infected root canal systems: A systematic review and meta-analysis.

Photodiagnosis Photodyn Ther 2019 Feb 9. Epub 2019 Feb 9.

Oral Microbiology Laboratory, Department of Microbiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

Background: To investigate the efficacy of antimicrobial photodynamic therapy (aPDT) adjunctive to conventional chemo-mechanical debridement of root canal system in patients with endodontic infections.

Methods: A meta-analysis was done according to the Cochrane Collaboration recommendations and PRISMA statement. Two independent reviewers performed an extensive literature search on electronic databases of MEDLINE, EMBASE, and SCOPUS up to January 2019. Read More

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http://dx.doi.org/10.1016/j.pdpdt.2019.02.009DOI Listing
February 2019

Quorum-sensing-regulated virulence factors in Pseudomonas aeruginosa are affected by sub-lethal photodynamic inactivation.

Photodiagnosis Photodyn Ther 2019 Feb 9. Epub 2019 Feb 9.

Department of Microbiology, School of Biology, College of Science, University of Tehran, Tehran, Iran. Electronic address:

Background: Photodynamic inactivation (PDI) is being recognized as a new antimicrobial approach. It is likely that in human hosts receiving this therapy, pathogens may encounter sub-lethal doses of PDI (sPDI), which may affect microbial virulence. This study was aimed to evaluate the effect of sPDI using methylene blue (MB) on the expression of genes belonging to two quorum sensing (QS) operons (rhl and las systems) and two genes necessary for pyocyanin and rhamnolipid production (phzM and rhlA) under QS control in Pseudomonas aeruginosa. Read More

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http://dx.doi.org/10.1016/j.pdpdt.2019.02.010DOI Listing
February 2019
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PDT@RSM-5. Monday November 26th at the Royal Society of Medicine, London.

Authors:
K Moghissi

Photodiagnosis Photodyn Ther 2019 Feb 7. Epub 2019 Feb 7.

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http://dx.doi.org/10.1016/j.pdpdt.2019.02.008DOI Listing
February 2019

Monitoring Photodynamic Oxygen Consumption by Endogenous Oxygen Contrast MRI.

Photodiagnosis Photodyn Ther 2019 Feb 7. Epub 2019 Feb 7.

Department of Photomedicine and Physical Chemistry, Faculty of Medicine, University of Rzeszów, Aleja Rejtana 16A, 35-310, Rzeszów, Poland. Electronic address:

Photodynamic oxygen consumption was measured by changes in spin-lattice relaxation time (T) in aqueous solution in a clinical GE scanner at 1.5 Tesla. Similar measurements were attempted in excised laryngeal and thyroid tissues that were infused with Rose Bengal. Read More

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http://dx.doi.org/10.1016/j.pdpdt.2019.02.007DOI Listing
February 2019

Photo-induced anti-inflammatory activities of chloro substituted subphthalocyanines on the mammalian macrophages in vitro.

Photodiagnosis Photodyn Ther 2019 Feb 7. Epub 2019 Feb 7.

Department of Energy Systems Engineering, Faculty of Engineering, Tarsus University, Tarsus, Mersin, Turkey.

In this study, a series of subphthalocyanines (SubPcs) derivatives were synthesized to generate unique immunomodulatory molecules that can be activated through photo-induction. Immunomodulatory agents have a great potential in the medicine to manipulate the immune system according to our needs and prevent the disease symptoms. Inflammation is one of these symptoms and macrophages play a crucial role in the generation of inflammatory responses. Read More

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http://dx.doi.org/10.1016/j.pdpdt.2019.02.002DOI Listing
February 2019

The different imaging characteristics between unilateral and bilateral polypoidal choroidal vasculopathy.

Photodiagnosis Photodyn Ther 2019 Feb 6. Epub 2019 Feb 6.

Department of Ophthalmology, First Hospital of China Medical University, Shenyang, China. Electronic address:

Purpose: To investigate the different imaging characteristics between unilateral and bilateral polypoidal choroidal vasculopathy (PCV) cases, based on confocal scanning laser ophthalmoscopes.

Materials: For this retrospective case series study, diagnostic indocyanine green angiography (ICGA) and spectral domain optical coherence tomography (SD-OCT) were performed to assess the eligible PCV eyes.

Results: Among the 53 patients at baseline, 14 showed bilateral PCV lesions, including two cases of branching vessel network (BVN) without leakage. Read More

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http://dx.doi.org/10.1016/j.pdpdt.2019.02.004DOI Listing
February 2019

Human papillomavirus DNA detection-guided ALA-photodynamic therapy for anogenital condyloma acuminata: a report of two cases.

Photodiagnosis Photodyn Ther 2019 Feb 6. Epub 2019 Feb 6.

Department of Dermatology and Venereology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China. Electronic address:

5-aminolevulinic acid (ALA) mediated photodynamic therapy (PDT) is a highly effective, safe, and promising treatment for human papillomavirus (HPV)-induced anogenital condyloma acuminata (CA). Specific HPV subtypes are responsible for the pathogenesis of CA and dynamic changes in viral loads may reflect the efficiency of PDT. Here we present two cases of anogenital CA successfully treated by ALA-PDT under the guidance of HPV DNA detection including genotype identification and viral load measurement, which provided clues for unexpected intra-anal infection. Read More

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http://dx.doi.org/10.1016/j.pdpdt.2019.02.003DOI Listing
February 2019
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Bright spot analysis for photodynamic diagnosis of brain tumors using confocal microscopy.

Photodiagnosis Photodyn Ther 2019 Feb 6. Epub 2019 Feb 6.

Department of Neurosurgery Graduate School of Medical Science, Kanazawa University, Takara-machi, Kanazawa 920-8641, Japan.

Background: In a previous study of photodynamic tumor diagnosis using 5-aminolevulinic acid (5-ALA), the authors proposed using fluorescence intensity and bright spot analyses under confocal microscopy for the precise discrimination of tumorous brain tissue (such as glioblastoma, GBM) from normal tissue. However, it remains unclear if bright spot analysis can discriminate infiltrating tumor in the boundary zone and whether this method is suitable for GBM with no 5-ALA fluorescence or for other tumor types.

Methods: Brain tumor tissue resected from 5-ALA-treated patients was sectioned to evaluate bright spots under confocal microscopy with a 544. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15721000183037
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http://dx.doi.org/10.1016/j.pdpdt.2019.02.005DOI Listing
February 2019
2 Reads

Utilizing photosensitizing and radiosensitizing properties of TiO-based mitoxantrone imprinted nanopolymer in killing fibrosarcoma and melanoma cells.

Photodiagnosis Photodyn Ther 2019 Feb 6. Epub 2019 Feb 6.

Medical Physics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:

Background: Some materials such as TiO display a luminescence property when exposed to X-ray radiation. Therefore, a proper photosensitizer can induce photodynamic effects by absorbing the emitted photons from these materials during radiotherapy. In this way, the problem of limited photo- penetration depth in photodynamic therapy is resolved. Read More

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http://dx.doi.org/10.1016/j.pdpdt.2019.02.006DOI Listing
February 2019
2.014 Impact Factor

Daylight photodynamic therapy in 25 patients with actinic keratosis and evaluation of efficacy by confocal microscopy.

Photodiagnosis Photodyn Ther 2019 Feb 2. Epub 2019 Feb 2.

Dermatology Department, Centro Hospitalar Vila Nova de Gaia/Espinho EPE, Rua Conceição Fernandes, 4434-502, Vila Nova de Gaia, Portugal.

Background: Daylight photodynamic therapy has been reported as having similar efficacy to conventional photodynamic therapy in actinic keratosis treatment.

Methods: 25 patients with actinic keratosis of the scalp and/or face were submitted to a daylight photodynamic therapy session. Adverse reactions were evaluated after one week and efficacy after 3 months. Read More

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http://dx.doi.org/10.1016/j.pdpdt.2019.02.001DOI Listing
February 2019

Effect of Er,Cr:YSGG on bond strength and microleakage of dentin bonded to resin composite with different distance and irradiation time.

Photodiagnosis Photodyn Ther 2018 Oct 26;25:204-207. Epub 2018 Oct 26.

Department of Prosthetic Dental Sciences, College of Dentistry, King Saud University. Eng. Abdullah Bugshan research chair for Dental and Oral Rehabilitation, Riyadh, Saudi Arabia. Electronic address:

Background: To explore the surface modification of dentin using Er,Cr:YSGG phototherapy and bonding system on the shear bond strength and microleakage scores at two different distances and times of laser irradiation.

Materials And Methods: Ninety disease-free third molars were collected for the experiment. The four laser groups were divided on the basis of non-contact mode distance and time of irradiation: Group-I: Distance of 1 mm with duration of 60 s; Group-II: Distance of 1 mm with duration of 120 s; Group-III: Distance of 2 mm with duration of 60 s and; Group-IV: Distance of 2 mm with duration of 120 s. Read More

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http://dx.doi.org/10.1016/j.pdpdt.2018.10.017DOI Listing
October 2018

The Comparison of Intracanal Medicaments, Diode Laser and Photodynamic Therapy on Removing the Biofilm of Enterococcus faecalis and Candida Albicans in the Root Canal System (Ex-vivo Study).

Photodiagnosis Photodyn Ther 2019 Jan 29. Epub 2019 Jan 29.

Dental school of Tehran Azad University, Unit 11, No. 45, Ravanpour St Nelson Mandela St., 1966845471, Tehran, Iran. Electronic address:

Background And Aim: Long term success in endodontic therapy is attributed to removal and debridement of intracanal microorganisms. The aim of this study was to compare the antimicrobial effects calcium hydroxide (Ca(OH)), triple antibiotic paste (TAP), photodynamic therapy(PDT), toluidine blue(TOL), light emitting diode (LED) and 940 nm diode laser (DL) on the biofilm of Enterococcus faecalis and Candida albicans in the root canal system of ex-vivo human teeth.

Materials & Methods: 84 intact, uniradicular, extracted human premolar teeth were prepared and the apical foramina were sealed with glass ionomer. Read More

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http://dx.doi.org/10.1016/j.pdpdt.2019.01.033DOI Listing
January 2019

Tom Dougherty: a Memorial.

Authors:
William R Potter

Photodiagnosis Photodyn Ther 2019 Jan 29. Epub 2019 Jan 29.

166 Coriander Court, East Amherst NY 14051, United States. Electronic address:

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http://dx.doi.org/10.1016/j.pdpdt.2019.01.032DOI Listing
January 2019

Evaluation of mTHPC-loaded PLGA nanoparticles for in vitro photodynamic therapy on C6 glioma cell line.

Photodiagnosis Photodyn Ther 2019 Jan 29. Epub 2019 Jan 29.

Laboratoire de Recherche en Nanosciences LRN EA 4682, University of Reims Champagne-Ardenne URCA, 51685, Reims Cedex 2, France; CBMN CNRS UMR 5248, Université de Bordeaux, INP Bordeaux, 33600 Pessac, France. Electronic address:

Photodynamic therapy (PDT) is a very attractive strategy to complement or replace common cancer treatments such as radiotherapy, surgery, and chemotherapy. If some molecules have shown their efficiency as photosensitizers (PS), many issues have to be solved such as the inherent cytotoxicity of the PS or its hydrophobic properties causing limitation in their solubility and leading to side effects. In this study, the encapsulation of an approved PS, the meso-tetra hydroxyphenylchlorine (mTHPC, Foscan®) within biocompatible and biodegradable poly(D, L-lactide-co-glycolide) acid (PLGA) NPs prepared by the nanoprecipitation method was studied. Read More

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http://dx.doi.org/10.1016/j.pdpdt.2019.01.026DOI Listing
January 2019
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Identification of extrahepatic metastasis of hepatocellular carcinoma using indocyanine green fluorescence imaging.

Photodiagnosis Photodyn Ther 2019 Jan 29. Epub 2019 Jan 29.

Department of Hepatobiliary Surgery, Affiliated Hospital, Southwest Medical University, Luzhou 646000, China. Electronic address:

Background/purpose: Intraoperative fluorescence imaging with indocyanine green (ICG) plays a significant role in the identification of hepatocellular carcinoma (HCC) during Hepatectomy. Despite that, few researchers have reported using ICG fluorescence imaging to detect extrahepatic metastases. Herein, we report the successful application of ICG fluorescence imaging in the detection of extrahepatic metastatic lesions from primary liver cancer. Read More

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http://dx.doi.org/10.1016/j.pdpdt.2019.01.031DOI Listing
January 2019
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Treatment of multi-position condyloma acuminatum with topical CO laser combined photodynamic therapy - Report of 6 cases.

Photodiagnosis Photodyn Ther 2019 Jan 28. Epub 2019 Jan 28.

Department of Dermatology, Affiliated Hospital of Qingdao University, Qingdao, China.

Background: Condyloma acuminatum(CA)is a venereal disease associated with a high rate of recurrence due to the rapid replication and subtle immune escape mechanism of Human Papillomavirus(HPV). Topical CO laser can remove verruca accurately. Photodynamic therapy with 5-aminolevulinic acid(PDT-ALA) is an effective therapy which targets on HPV infected sites. Read More

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http://dx.doi.org/10.1016/j.pdpdt.2019.01.030DOI Listing
January 2019
1 Read

Does bond integrity of bleached enamel increases with phototherapy? A systematic review.

Photodiagnosis Photodyn Ther 2019 Jan 28. Epub 2019 Jan 28.

Department of Restorative Dental Science, Operative Division, College of Dentistry, King Saud University, Riyadh, Saudi Arabia. Electronic address:

Background: The aim of the current systematic review was to evaluate the efficacy of phototherapy (PT) on bond strength of bleached enamel.

Methods: Electronic databases including MEDLINE (PubMed), ISI Web of Science, Scopus, ScIELO, LILACS and EMBASE until January 2019. The addressed focused question was: "Does PT increase the bond integrity of bleached enamel?" Only in-vitro studies evaluating the effect of PT compared with bleaching agent or no phototherapy were included. Read More

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http://dx.doi.org/10.1016/j.pdpdt.2019.01.029DOI Listing
January 2019

Influence of curcumin photosensitizer in photodynamic therapy on the mechanical properties and push-out bond strength of glass-fiber posts to intraradicular dentin.

Photodiagnosis Photodyn Ther 2019 Jan 24. Epub 2019 Jan 24.

Department of Restorative Dentistry, Discipline of Endodontics, Araçatuba School of Dentistry, São Paulo State University, UNESP, Araçatuba, SP, Brazil. Electronic address:

Background: The effects of using curcumin as photosensitizer on the mechanical properties of intraradicular dentin and on the bond strength of glass-fiber posts are unknown. Thus, this in vitro study evaluated the influence of using curcumin as photosensitizer during photodynamic therapy on the Martens hardness, elastic modulus, and bond strength of glass-fiber posts luted to intraradicular dentin, in different tooth root thirds.

Methods: Eighty bovine teeth were divided into 5 groups according to the concentration of curcumin applied, with or without blue LED light activation: Control-deionized water; Curcumin 500 mg/L; Curcumin 500 mg/L + blue LED; Curcumin 1000 mg/L; and Curcumin 1000 mg/L + blue LED. Read More

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http://dx.doi.org/10.1016/j.pdpdt.2019.01.025DOI Listing
January 2019
1 Read

Modeling PpIX effective light fluence at depths into the skin for PDT dose comparison.

Photodiagnosis Photodyn Ther 2019 Jan 24. Epub 2019 Jan 24.

Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA; Department of Surgery, Geisel School of Medicine, Dartmouth College, Lebanon, NH 03756, USA.

Background: Daylight-activated PDT has seen increased support in recent years as a treatment method for actinic keratosis and other non-melanoma skin cancers. The inherent variability observed in broad-spectrum light used in this methodology makes it difficult to plan and monitor light dose, or compare to lamp light doses.

Methods: The present study expands on the commonly used PpIX-weighted effective surface irradiance metric by introducing a Monte Carlo method for estimating effective fluence rates into depths of the skin. Read More

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http://dx.doi.org/10.1016/j.pdpdt.2019.01.022DOI Listing
January 2019
4 Reads

UTILISATION OF ANTIMICROBIAL PHOTODYNAMIC THERAPY AS AN ADJUNCTIVE TOOL FOR OPEN FLAP DEBRIDEMENT IN THE MANAGEMENT OF CHRONIC PERIODONTITIS: A RANDOMIZED CONTROLLED CLINICAL TRIAL.

Photodiagnosis Photodyn Ther 2019 Jan 23. Epub 2019 Jan 23.

Department of Periodontology, Swargiya Dadasaheb Kalmegh Smruti (S.D.K.S) Dental College and Hospital, Nagpur, Maharashtra, 440007, India. Electronic address:

Background: Antimicrobial photodynamic therapy (aPDT) has proved to be an effective adjunctive modality with potential benefits in the management of chronic periodontitis. The combination of photothermal and photodynamic effects of Indocyanine green (ICG) dye, when it is photoactivated with a diode laser of 810 nm wavelength, has been well documented in literature.

Aim: This study was conducted to evaluate whether a single session of antimicrobial photodynamic therapy using ICG dye-810 nm diode laser combination can provide a substantial benefit when it is utilised as an adjunct to open flap debridement (OFD) in the management of chronic periodontitis. Read More

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http://dx.doi.org/10.1016/j.pdpdt.2019.01.023DOI Listing
January 2019
2 Reads
2.014 Impact Factor

1Gold Nanoparticles Application in Liver Cancer.

Photodiagnosis Photodyn Ther 2019 Jan 23. Epub 2019 Jan 23.

Department of Medical Biotechnology, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address:

Studies have shown that hepatocellular carcinoma (HCC) (the most important types of liver cancer) is the fifth most common cancer, and the third cause of mortality, globally. Although major progress has been made in the treatment and diagnosis of this disease, its eradication remains limited. Consequently, discovering new diagnosis and treatment methods is important. Read More

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http://dx.doi.org/10.1016/j.pdpdt.2019.01.027DOI Listing
January 2019
1 Read

The effect of antimicrobial photodynamic therapy on the expression of biofilm associated genes in Staphylococcus aureus strains isolated from wound infections in burn patients.

Photodiagnosis Photodyn Ther 2019 Jan 23. Epub 2019 Jan 23.

Oral Microbiology Laboratory, Department of Microbiology, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

Purpose: Burn patients are particularly susceptible to microbial infection. Staphylococcus aureus causes burn wound, impetigo and cellulitis. Although sub-lethal antimicrobial photodynamic therapy (aPDT) would not result in microorganism killing, it can considerably influence microbial virulence factor. Read More

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http://dx.doi.org/10.1016/j.pdpdt.2019.01.028DOI Listing
January 2019
2 Reads

Antimicrobial effects of photodynamic therapy with antiseptics on Staphylococcus aureus biofilm on titanium surface.

Photodiagnosis Photodyn Ther 2019 Jan 23. Epub 2019 Jan 23.

School and Hospital of Stomatology, Fujian Medical University, Fuzhou, China; Key Laboratory of Stomatology, Fujian Province University, Fuzhou, China. Electronic address:

Background: S. aureus biofilm plays a predominant role in the establishment and development of peri-implantitis. It is suggested to combine different modalities in peri-implantitis treatment. Read More

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http://dx.doi.org/10.1016/j.pdpdt.2019.01.024DOI Listing
January 2019
2 Reads

INTRODUCTION OF 5-AMINOLEVULINIC ACID AS A THERANOSTICS AGENT IN DENTISTRY.

Photodiagnosis Photodyn Ther 2019 Jan 16. Epub 2019 Jan 16.

Department of Chemical Engineering, Babol Noshirvani University of Technology, Babol, Po.Box: 47148-71167, Iran.

Objective: The aim of this paper is to study thetheranostics potentials of 5-Aminolevulinic Acid (5-ALA)in dentistry.

Methods: Photodynamic inactivation (PDI) and fluorescence spectroscopy of Streptococcus sanguis, and laser induced fluorescence (LIF) of several decayed teeth were performed using 5-ALA.

Results: In the absence of 5-ALA, 15 min illumination of the bacteria by the means of an LED light source led to only 1. Read More

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http://dx.doi.org/10.1016/j.pdpdt.2019.01.021DOI Listing
January 2019
1 Read

Influence of antimicrobial photodynamic therapy as an adjunctive to scaling and root planing on alveolar bone loss: a systematic review and meta-analysis of animal studies.

Photodiagnosis Photodyn Ther 2019 Jan 15. Epub 2019 Jan 15.

UNESP, São Paulo State University, Group of Study and Research in Lasers in Dentistry, School of Dentistry, Araçatuba, SP, Brazil. Electronic address:

Background: The study aimed to evaluate the effect of antimicrobial photodynamic therapy (aPDT) as adjunctive therapy to scaling and root planing in experimental periodontitis in rats, with or without systemic involvement, by means of histometric analysis of the furcation region.

Methods: Systematic search was done using PubMed/MEDLINE, SCOPUS, EMBASE and ProQuest databases. Quantitative analysis of alveolar bone loss, with subcategories for the experimental periods studied, was performed. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15721000183026
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http://dx.doi.org/10.1016/j.pdpdt.2019.01.020DOI Listing
January 2019
4 Reads

Photophysicochemical and photodynamic therapy properties of metallophthalocyanines linked to gold speckled silica nanoparticles.

Photodiagnosis Photodyn Ther 2019 Jan 15. Epub 2019 Jan 15.

Center for Nanotechnology Innovation, Department of Chemistry, South Africa. Electronic address:

This work reports on the linkage of 2(3),9(10),16(17),23(24) tetrakis [(benzo[d]thiazol-2-yl phenoxy) phthalocyaninato] zinc(II) (1) and indium(III) chloride (2) to gold speckled silica (GSS) nanoparticles via gold to sulphur (Au-S) and gold to nitrogen (Au-N) self-assembly to form the conjugates (1-GSS and 2-GSS). The formed conjugates were characterized using microscopic and spectroscopic techniques, and the photophysicochemical properties and photodynamic therapy (PDT) activity against human breast adenocarcinoma cell line (MCF-7 cells) were studied. The conjugates afforded decrease in fluorescence quantum yields with corresponding increase in triplet and singlet oxygen quantum yields when compared to phthalocyanines alone. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15721000183041
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http://dx.doi.org/10.1016/j.pdpdt.2019.01.019DOI Listing
January 2019
4 Reads

Efficacy of phototherapy with different conventional surface treatments on adhesive quality of lithium disilicate ceramics.

Photodiagnosis Photodyn Ther 2019 Jan 12. Epub 2019 Jan 12.

Department of Prosthetic Dental Sciences, College of Dentistry, King Saud University, Po-Box: 60169, Riyadh 11545, Saudi Arabia. Electronic address:

Aim: The aim of the present study was to evaluate shear bond strength (SBS) of LDC and resin composite in combination with phototherapy and different ceramic surface treatments.

Materials And Method: Forty Lithium Disilicate Glass Ceramic (LDC) disks measuring (4 × 4 x 9 mm) were fabricated. The specimens were randomly divided into four groups (n = 10 each) according to the surface treatment. Read More

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http://dx.doi.org/10.1016/j.pdpdt.2019.01.015DOI Listing
January 2019
2 Reads

Influence of phototherapy on adhesive strength and microleakage of bleached enamel bonded to orthodontic brackets: An Invitro study.

Photodiagnosis Photodyn Ther 2019 Jan 12. Epub 2019 Jan 12.

Department of Orthodontics, Karachi Medical and Dental College FCPS Part II resident, Karachi, Pakistan. Electronic address:

Aim: The aim of the present in-vitro study was to explore bleached enamel reversal with phototherapy (Er,Cr:YSGG) when using two dissimilar bonding system to bond brackets on microleakage and shear bond strength.

Material And Methods: Amongst one twenty samples, ninety samples were bleached using 35% hydrogen peroxide. After the bleaching procedure, the teeth were randomly divided into three groups according to surface conditioning treatment (n = 30 each). Read More

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http://dx.doi.org/10.1016/j.pdpdt.2019.01.013DOI Listing
January 2019
3 Reads
2.014 Impact Factor

Evaluation of tooth wear by estimating enamel thickness with quantitative light-induced fluorescence technology.

Photodiagnosis Photodyn Ther 2019 Jan 12. Epub 2019 Jan 12.

Department of Preventive Dentistry & Public Oral Health, BK21 PLUS project, Yonsei University College of Dentistry, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea. Electronic address:

Background: Various techniques have been suggested to quantitatively assess tooth wear; most have limited clinical application. The first aim of this in vitro study was to estimate the residual enamel thickness of teeth with various degrees of occlusal wear using quantitative light-induced fluorescence (QLF). The second aim was to identify relationships between the fluorescence parameters of QLF and the conventional tooth wear index (TWI) system. Read More

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http://dx.doi.org/10.1016/j.pdpdt.2019.01.016DOI Listing
January 2019
2 Reads

Cucurbit[7]uril enhance the photosensitization of porphyrins in Neuroblastoma cells.

Photodiagnosis Photodyn Ther 2019 Jan 12. Epub 2019 Jan 12.

Department of Chemistry, Guizhou Medical University, Guiyang 550025, Guizhou, China. Electronic address:

Neuroblastoma is the most common extracranial solid tumor of childhood. Advancements in treatments have improved survival rate of child suffering from this ailment. Novel therapeutic techniques may further reduce cancer related mortality. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15721000183038
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http://dx.doi.org/10.1016/j.pdpdt.2019.01.017DOI Listing
January 2019
6 Reads

STRATIFICATION OF THE DYSPLASIA AND NEOPLASIA RISK USING AUTOFLUORESCENCE ENDOSCOPIC SURVEILLANCE OF BARRETT'S ESOPHAGUS.

Photodiagnosis Photodyn Ther 2019 Jan 12. Epub 2019 Jan 12.

School of Medicine with the Division of Dentistry in Zabrze, Department of Internal Diseases, Angiology and Physical Medicine, Center for Laser Diagnostics and Therapy, Medical University of Silesia in Katowice, Batorego Street 15, 41-902 Bytom, Poland. Electronic address:

Background: This study assessed the efficacy of autofluorescence endoscopy (AFE) using the Onco-LIFE system and numerical color value (NCV) estimation in comparison to white light endoscopy (WLE) in endoscopic surveillance for identification of early dysplasia in Barrett's esophagus (BE) to aid in real-time image elucidation and minimize the overreliance on biopsy and histology.

Methods: AFE, performed simultaneously during WLE, with biopsy was performed among 24 patients with BE. None of these patients had any obvious mucosal abnormalities in WLE. Read More

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http://dx.doi.org/10.1016/j.pdpdt.2019.01.012DOI Listing
January 2019
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Antimicrobial efficacy of photodynamic therapy on dental implant surfaces: A systematic review of in vitro studies.

Photodiagnosis Photodyn Ther 2019 Jan 12. Epub 2019 Jan 12.

Department of Preventive Dental Sciences, College of Dentistry, Prince Sattam bin Abdulaziz University, Alkharj, Saudi Arabia. Electronic address:

Background: To systematically review the literature regarding the antimicrobial effects of photodynamic therapy (PDT) on the multi-bacterial species and the possible surface alterations of the dental implants as a result of PDT METHODS: The addressed focused question was: "Does PDT show antimicrobial efficacy against multi-bacterial species colonization and result in surface alteration on dental implants?" Electronic databases including MEDLINE and EMBASE up to and including December 2018 were searched.

Results: Seven studies were included. Two studies used a total of 110 titanium dental implants, while 1 study included a total of 72 zirconia dental implants. Read More

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http://dx.doi.org/10.1016/j.pdpdt.2019.01.018DOI Listing
January 2019
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Evaluation of calculus imaging on root surfaces by spectral-domain optical coherence tomography.

Photodiagnosis Photodyn Ther 2019 Jan 12. Epub 2019 Jan 12.

Department of Cariology, Endodontology and Periodontology, University of Leipzig, Liebigstr. 12, 04103, Leipzig, Germany. Electronic address:

Objective: The aim of this in vitro study was to evaluate the ability of optical coherence tomography (OCT) to display calculus on root surfaces.

Material And Methods: Ten teeth with calculus on the root surface were embedded in resin, omitting the root surface. A region of interest (ROI) was marked by small drill holes coronally and apically of the calculus and imaged by spectral-domain optical coherence tomography ([SD OCT], Telesto SP5, centre wavelength 1310 nm) and light microscopy (LM). Read More

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http://dx.doi.org/10.1016/j.pdpdt.2019.01.014DOI Listing
January 2019
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2.014 Impact Factor

Expression of peptide transporter 1 has a positive correlation in protoporphyrin IX accumulation induced by 5-aminolevulinic acid with photodynamic detection of non-small cell lung cancer and metastatic brain tumor specimens originating from non-small cell lung cancer.

Photodiagnosis Photodyn Ther 2019 Jan 10. Epub 2019 Jan 10.

Department of Neurosurgery, Nara Medical University, Kashihara, Nara, Japan.

Background: Recently, 5-aminolevulinic acid (5-ALA)-induced protoporphyrin IX fluorescence was reported to be an useful tool during total surgical resection of high-grade gliomas. However, the labeling efficacy of protoporphyrin IX fluorescence is lower in metastatic brain tumors compared to that in high-grade gliomas, and the mechanism underlying protoporphyrin IX fluorescence in metastatic brain tumors remains unclear. Lung cancer, particularly non-small cell lung cancer (NSCLC), is the most common origin for metastatic brain tumor. Read More

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http://dx.doi.org/10.1016/j.pdpdt.2019.01.009DOI Listing
January 2019
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Synergistic in vitro effects of indocyanine green and ethylenediamine tetraacetate-mediated photodynamic antimicrobial chemotherapy combined with antibiotics for resistant bacterial biofilms in diabetic foot infection.

Photodiagnosis Photodyn Ther 2019 Jan 8. Epub 2019 Jan 8.

Department of Pharmacy, First Affiliated Hospital of Chongqing Medical University, Chongqing, China. Electronic address:

Background: Antibiotic resistance has emerged as one of the most important determinants in diabetic foot infections outcomes. Photodynamic antimicrobial chemotherapy (PACT) has been proposed as an alternative approach for inactivating bacteria, especially resistant bacterial biofilms. This research investigated the synergistic effects of PACT mediated by the photosensitizer indocyanine green (ICG) and ethylenediamine tetraacetate (EDTA) combined with antibiotics against common pathogens of diabetic foot ulcer infection, including Staphylococcus aureus and Pseudomonas aeruginosa, in vitro. Read More

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http://dx.doi.org/10.1016/j.pdpdt.2019.01.010DOI Listing
January 2019
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Plum-blossom needle assisted photodynamic therapy: The therapy option for the treatment of oral potentially malignant disorder in the elderly.

Photodiagnosis Photodyn Ther 2019 Jan 8. Epub 2019 Jan 8.

Department of Oral Medicine, Peking University School and Hospital of Stomatology, Beijing 100081, PR China. Electronic address:

Oral leukoplakia (OLK) is one of the most common oral potentially-malignant disorders (OPMD) with complex causes, a long disease course and a high tendency for recrudescence. Although a variety of methods exist for treating this disease, canceration rates remain high. Herein, we described a case of 72-year-old male patient with OLK of the palatine mucous membrane who had achieved complete remission after being treated with five sessions of plum-blossom needle (PBN) assisted 5-aminolevulinic acid-photodynamic therapy (ALA-PDT). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15721000183034
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http://dx.doi.org/10.1016/j.pdpdt.2019.01.011DOI Listing
January 2019
10 Reads
2.014 Impact Factor

PHOTOACTIVATED RESVERATROL AGAINST Staphylococcus aureus INFECTION IN MICE.

Photodiagnosis Photodyn Ther 2019 Jan 7. Epub 2019 Jan 7.

Federal University of Bahia, Anísio TeixeiraCampus- Multidisciplinary Institute in Health, 58 Rio de Contas Street - 17 Block - 58 Lot, Candeias, 45.029-094, Vitória da Conquista, Bahia, Brazil. Electronic address:

Background: Among the pathogens, Staphylococcus aureus is the main causative agent of bacterial diseases in the world. In this context, antimicrobial photodynamic therapy (aPDT) appears as a promising tool by means of microbial inactivation with the use of light. aPDT is applied in treatments involving photosensitizers capable of generating oxygen free radicals. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15721000183022
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http://dx.doi.org/10.1016/j.pdpdt.2019.01.005DOI Listing
January 2019
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Photodynamic therapy prevented the recurrence of lymphomatoid papulosis.

Photodiagnosis Photodyn Ther 2019 Jan 6. Epub 2019 Jan 6.

Tachibana Dermatology Clinic, Uonuma, Japan.

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http://dx.doi.org/10.1016/j.pdpdt.2019.01.007DOI Listing
January 2019
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Effectiveness of scaling and root planning with and without adjunct antimicrobial photodynamic therapy in the treatment of chronic periodontitis among cigarette-smokers and never-smokers: A randomized controlled clinical trial.

Photodiagnosis Photodyn Ther 2019 Jan 5. Epub 2019 Jan 5.

Department of Oral Restorative and Rehabilitative Sciences, UWA Dental School, The University of Western Australia (M512), 17 Monash Avenue, Nedlends, WA, 6009, Perth, Australia. Electronic address:

Objective: The aim of the present short-term randomized clinical trial was to assess the efficacy of scaling and root planing (SRP) with and without adjunct antimicrobial photodynamic therapy (aPDT) in the treatment of chronic periodontitis (CP) among cigarette-smokers and never-smokers.

Materials And Methods: Demographic information was collected using a questionnaire. Cigarette-smokers (group-1) and never-smokers (group-2) with CP were included. Read More

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http://dx.doi.org/10.1016/j.pdpdt.2019.01.006DOI Listing
January 2019
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2.014 Impact Factor

Comparison of different non-invasive diagnostic techniques used for HMME-PDT in the treatment of port wine stains.

Photodiagnosis Photodyn Ther 2019 Jan 6. Epub 2019 Jan 6.

Institute of Photomedicine, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, China. Electronic address:

Background: Hemoporfin-mediated photodynamic therapy (HMME-PDT) is an effective method for treating port wine stains (PWS). While, it still lacks methods to evaluate the treatment of HMME-PDT for PWS effectively and objectively.

Objective: This study aimed to compare the value of different non-invasive diagnostic techniques used for HMME-PDT treatment evaluation in PWS. Read More

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http://dx.doi.org/10.1016/j.pdpdt.2019.01.008DOI Listing
January 2019
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Photodynamic Antimicrobial Chemotherapy (PACT), using Toluidine blue (TBO) inhibits both growth and dimorphism in Paracoccidioides brasiliensis by a mechanism involving reactive Oxygen species (ROS) production.

Photodiagnosis Photodyn Ther 2019 Jan 3. Epub 2019 Jan 3.

Instituto de Pesquisa e Desenvolvimento - IP&D, Universidade do Vale do Paraíba - UNIVAP, Av. Shishima Hifumi, 2911, São José dos Campos, SP, Brazil. Electronic address:

Background: The thermo-dimorphic fungus Paracoccidioides brasiliensis causes Paracoccidioidomycosis (PCM), an important public health problem in Latin American, with prevalence in Brazil [1-4]. One of the main problems of this mycosis, initially pulmonary, are the secondary mucosal lesions, which are debilitating, painful and, in some cases, generate mutilations [3,5-8]. The treatment is performed through the use of oral medicines anti-fungal and/or oral surgeries [3]. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15721000183037
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http://dx.doi.org/10.1016/j.pdpdt.2019.01.003DOI Listing
January 2019
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The capabilities and hope of the combination the new forms of personalized colon cancer treatment - immunotherapy and immune photodynamic therapy.

Photodiagnosis Photodyn Ther 2019 Jan 3. Epub 2019 Jan 3.

School of Medicine with the Division of Dentistry in Zabrze, Department of Internal Diseases, Angiology and Physical Medicine, Center for Laser Diagnostics and Therapy, Medical University of Silesia, Batorego Street 15, 41-902 Bytom, Poland. Electronic address:

Introduction: PDT can interfere with cytokine-mediated responses that play an important role in the processes of cancer progression, tumor angiogenesis and metastasis. Therefore, based on the identification of these cancer biomarkers, the therapy of combining various forms of treatment, including immunotherapy and PDT, may be a justified strategy for colorectal cancer treatment that focuses on individualized comprehensive therapy.

Method: We reviewed the major approaches on the use of immunotherapy in colorectal cancer, with the special regard to photodynamic therapy, its immunological effect and new oncological treatment directions, connected with adjuvant immunotherapy including use of nanoparticles. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15721000183038
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http://dx.doi.org/10.1016/j.pdpdt.2019.01.004DOI Listing
January 2019
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Assessment of tooth wear based on autofluorescence properties measured using the QLF technology in vitro.

Photodiagnosis Photodyn Ther 2019 Jan 3. Epub 2019 Jan 3.

Department of Preventive Dentistry & Public Oral Health, BK21 PLUS Project, Oral Science Research Institute, Yonsei University College of Dentistry, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 03722, Republic of Korea. Electronic address:

Background: The difference in autofluorescence between enamel and dentine layer has prompted recommendations to use the quantitative light-induced fluorescence (QLF) method for quantifying tooth wear (TW). This study investigated the potential of QLF for distinguishing the severity of occlusal TW based on differences in the autofluorescence intensity.

Methods: In total, 106 extracted permanent molars and premolars having suspected wear without pulp exposure were used. Read More

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http://dx.doi.org/10.1016/j.pdpdt.2019.01.001DOI Listing
January 2019
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Physio-mechanical and antimicrobial properties of an orthodontic adhesive containing cationic curcumin doped zinc oxide nanoparticles subjected to photodynamic therapy.

Photodiagnosis Photodyn Ther 2019 Jan 3. Epub 2019 Jan 3.

Department of Orthodontics, Shahed University, Tehran, Iran. Electronic address:

Background: Potential complications on the crown level during fixed orthodontic procedures are white spot, enamel demineralization and the tooth decay. This study evaluated the antimicrobial properties of an orthodontic adhesive incorporating cationic curcumin doped zinc oxide nanoparticles (cCur/ZnONPs), which can have the highest concentration of cCur/ZnONPs and shear bond strength (SBS) value simultaneously, on the against cariogenic bacteria including Streptococcus mutans, Streptococcus sobrinus, and Lactobacillus acidophilus.

Materials And Methods: Following synthesis and confirmation of cCur/ZnONPs, SBS and adhesive remnant index (ARI) of the test adhesives containing cCur/ZnONPs (1. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15721000183035
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http://dx.doi.org/10.1016/j.pdpdt.2019.01.002DOI Listing
January 2019
8 Reads

Effect of phototherapy on dentin bond strength and microleakage when bonded to resin with different conditioning regimes.

Photodiagnosis Photodyn Ther 2018 Dec 29. Epub 2018 Dec 29.

Department of Prosthetic Dental Science, College of Dentistry, King Saud University, P O Box 60169, Riyadh 11545, Kingdom of Saudi Arabia. Electronic address:

Aim: To assess the efficacy of phototherapy on bond strength and microleakage of bulk fill composites in comparison to conventional dentin surface treatments.

Materials And Methods: Ninety human third molars were divided into 3 groups (n = 30 each) according to surface conditioning treatment. Group 1 (Etch and Bond) EB, group 2 was treated with Er,Cr: YSGG (ECL) and group 3 was treated with a diode laser (DL). Read More

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http://dx.doi.org/10.1016/j.pdpdt.2018.12.014DOI Listing
December 2018
2 Reads

Benefits of hypericin transport and delivery by low- and high-density lipoproteins to cancer cells: from in vitro to ex ovo.

Photodiagnosis Photodyn Ther 2018 Dec 28. Epub 2018 Dec 28.

Center for Interdisciplinary Biosciences, Technology and Innovation Park, P.J. Safarik University in Kosice, Jesenna 5, 041 54 Kosice, Slovakia. Electronic address:

Lipoproteins are very attractive natural-based transport systems suitable for applications in diagnostics and cancer therapy. Low- and high-density lipoproteins (LDL, HDL) were selected for hypericin (hyp) delivery in cancer cells. Hyp was used, as it is a well-known model for hydrophobic molecules, in order to estimate the LDL and HDL transport efficacy. Read More

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http://dx.doi.org/10.1016/j.pdpdt.2018.12.013DOI Listing
December 2018
1 Read