608 results match your criteria Photodermatology photoimmunology & photomedicine[Journal]


Effects of red light on inflammation and skin barrier recovery following acute perturbation. Pilot study results in healthy human subjects.

Photodermatol Photoimmunol Photomed 2018 Dec 5. Epub 2018 Dec 5.

Department of Dermatology, Radboud University Medical Center, René Descarstesdreef 1, 6500 HB, Nijmegen, The Netherlands.

In an original article recently published in Photodermatology, Photoimmunology and Photomedicine (1), we aimed to prove therapeutic effects of photobiomodulation (PBM) based on clinical outcomes by investigating the impact of UV-free blue light at 453 nm on the recovery of the skin barrier and on the cutaneous inflammatory response elicited by acute perturbation of the skin of healthy human volunteers. In this Letter we describe a study of same design and scope in which we investigated the impact of LED red light at 656 nm. Briefly, tape stripping and histamine iontophoresis were performed on the forearm of 22 healthy volunteers in two consecutive weeks: in one week, challenges were followed by irradiation with red light at 656 nm, in the other week (control), no light was administered. Read More

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December 2018
3 Reads

Frequency of occurrence of polymorphic light eruption in patients treated with photohardening and patients treated with phototherapy for other diseases.

Photodermatol Photoimmunol Photomed 2018 Sep 29. Epub 2018 Sep 29.

Research Unit for Photodermatology, Department of Dermatology, Medical University of Graz, Graz, Austria.

Background: Medical phototherapy can lead to the manifestation of polymorphic light eruption (PLE), though little is known about the frequency of such events.

Aims: The aim of this Austrian single center study was to retrospectively investigate over a 4-year time period the frequency of PLE in patients prone to the condition and patients with other diseases under phototherapy (mainly narrow-band and broad-band UVB).

Materials And Methods: The data for analysis were obtained from the electronic health and patient record database and patient files of the Photodermatology Unit, Department of Dermatology, Medical University of Graz, Austria. Read More

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September 2018
3 Reads

Adverse effects of topical photodynamic therapy: a consensus review and approach to management.

Br J Dermatol 2018 Sep 5. Epub 2018 Sep 5.

British Association of Dermatologists, London, U.K.

Background: Topical photodynamic therapy (PDT) is widely used to treat superficial nonmelanoma skin cancer and dysplasia, and is generally well tolerated. However, as with all treatments, adverse effects may occur and awareness may facilitate approaches to prevention and management.

Objectives: To review the available evidence relating to the adverse effects of topical PDT, to help inform recommendations in updated clinical guidelines produced by the British Association of Dermatologists and British Photodermatology Group, and the efficacy of preventative and therapeutic approaches. Read More

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September 2018
6 Reads

Cbl-b deficiency provides protection against UVB-induced skin damage by modulating inflammatory gene signature.

Cell Death Dis 2018 Aug 6;9(8):835. Epub 2018 Aug 6.

Research Unit for Photodermatology, Department of Dermatology and Venereology, Medical University of Graz, Graz, Austria.

Exposure of skin to ultraviolet (UV) radiation induces DNA damage, inflammation, and immune suppression that ultimately lead to skin cancer. However, some of the pathways that regulate these events are poorly understood. We exposed mice to UVB to study its early effects in the absence of Cbl-b, a known suppressor of antitumor immune response in the skin. Read More

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Rationale and Plan for Vitamin D Food Fortification: A Review and Guidance Paper.

Front Endocrinol (Lausanne) 2018 17;9:373. Epub 2018 Jul 17.

Clinic for Thoracic and Cardiovascular Surgery, Heart Center North Rhine-Westfalia, Ruhr University Bochum, Bad Oeynhausen, Germany.

Vitamin D deficiency can lead to musculoskeletal diseases such as rickets and osteomalacia, but vitamin D supplementation may also prevent extraskeletal diseases such as respiratory tract infections, asthma exacerbations, pregnancy complications and premature deaths. Vitamin D has a unique metabolism as it is mainly obtained through synthesis in the skin under the influence of sunlight (i.e. Read More

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July 2018
17 Reads
2 Citations

Photoonycholysis: new findings.

J Eur Acad Dermatol Venereol 2018 Jun 28. Epub 2018 Jun 28.

Photodermatology Department, Hospital Clinic de Barcelona, Barcelona, Spain.

First described in 1961, photoonycholysis (PO) is a rare nail alteration that may result from drug intake, from topical aminolevulinate photodynamic therapy or from photosensitive conditions such as porphyria or pseudoporphyria. Spontaneous PO is rare. This review updates the numerous causes of PO and highlights some new ways producing this condition. Read More

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A Perspective on the Interplay of Ultraviolet-Radiation, Skin Microbiome and Skin Resident Memory TCRαβ+ Cells.

Front Med (Lausanne) 2018 30;5:166. Epub 2018 May 30.

Research Unit for Photodermatology, Department of Dermatology, Medical University of Graz, Graz, Austria.

The human skin is known to be inhabited by diverse microbes, including bacteria, fungi, viruses, archaea, and mites. This microbiome exerts a protective role against infections by promoting immune development and inhibiting pathogenic microbes to colonize skin. One of the factors having an intense effect on the skin and its resident microbes is ultraviolet-radiation (UV-R). Read More

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May 2018
12 Reads

More manuscript submissions, higher quality science for Photodermatology, Photoimmunology & Photomedicine.

Authors:
Akimichi Morita

Photodermatol Photoimmunol Photomed 2018 05;34(3):166

Department of Geriatric and Environmental Dermatology, Nagoya City University Graduate School of Medical Sciences, Nagoya, 467-8601, Japan.

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Efficacy of phototherapy to treat facial ageing when using a red versus an amber LED: a protocol for a randomised controlled trial.

BMJ Open 2018 May 31;8(5):e021419. Epub 2018 May 31.

Biophotonics Applied to Health Sciences Postgraduate Program, Universidade Nove de Julho (UNINOVE), Sao Paulo, Brazil.

Introduction: The skin undergoes morphological and physiological changes with the advancing age of an individual. These changes may be caused by intrinsic and extrinsic factors that contribute to cellular ageing and consequent skin ageing. The term photoageing is used to characterise the ageing of the skin caused by solar radiation. Read More

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May 2018
2 Reads

Are photosensitizing medications associated with increased risk of important erythemal reactions during ultraviolet B phototherapy?

Br J Dermatol 2018 Nov 13;179(5):1184-1185. Epub 2018 Aug 13.

Ninewells Hospital and Medical School, Photobiology Unit, Department of Dermatology, Dundee, U.K.

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November 2018

8-Methoxypsoralen Plus Ultraviolet A Reduces the Psoriatic Response to Imiquimod in a Murine Model.

Acta Derm Venereol 2018 Jun;98(6):576-584

Research Unit for Photodermatology, Department of Dermatology and Venereology, Medical University of Graz, AT-8036 Graz, Austria.

The effects of 8-Methoxypsoralen plus ultraviolet A (PUVA) or ultraviolet B (UVB) alone on imiquimod-induced psoriasis were examined in a mouse model. Mouse skin was treated with repetitive sub-phototoxic doses of PUVA or UVB before or during the induction of toll-like receptor 7/8 activation and psoriasis through the application of imiquimod. PUVA, to a greater degree than UVB, suppressed the established imiquimod-induced psoriatic phenotype, but pretreatment with PUVA prior to administration of imiquimod also reduced the susceptibility of murine skin to respond to imiquimod to a greater degree than did pretreatment with UVB. Read More

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June 2018
12 Reads

Solarium Use and Risk for Malignant Melanoma: Meta-analysis and Evidence-based Medicine Systematic Review.

Anticancer Res 2018 02;38(2):1187-1199

Center for Clinical and Experimental Photodermatology, Saarland University, Campus Homburg, Homburg, Germany

Background: There is an ongoing debate whether solarium use (indoor tanning/artificial UV) may increase the risk for primary cutaneous malignant melanoma.

Aim: A systematic literature search was conducted using MEDLINE and ISI Web of Science. Included studies were critically assessed regarding their risk of bias, and methodological shortcomings. Read More

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February 2018
19 Reads

The Impact of UV-dose, Body Surface Area Exposed and Other Factors on Cutaneous Vitamin D Synthesis Measured as Serum 25(OH)D Concentration: Systematic Review and Meta-analysis.

Anticancer Res 2018 02;38(2):1165-1171

Center for Clinical and Experimental Photodermatology, The Saarland University Hospital, Homburg, Germany

Background/aim: To optimize public health campaigns concerning UV exposure, it is important to characterize factors that influence UV-induced cutaneous vitamin D production. This systematic review and meta-analysis investigated the impact of different individual and environmental factors including exposed body surface area (BSA), UVB dose and vitamin D status, on serum 25(OH)D concentration.

Materials And Methods: In accordance with Preferred Reporting Items for Systematic Reviews and Meta-analyses, and Meta-analysis of Observational studies in Epidemiology guidelines, a systematic literature search was conducted (MEDLINE; 01/1960-07/2016) investigating the impact of these factors on vitamin D status after artificial UV exposure as main outcome measure. Read More

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February 2018
9 Reads

A Critical Appraisal of the Recent Reports on Sunbeds from the European Commission's Scientific Committee on Health, Environmental and Emerging Risks and from the World Health Organization.

Anticancer Res 2018 02;38(2):1111-1120

Boston University Medical Center, Boston, MA, U.S.A.

The European Commission's Scientific Committee on Health, Environmental and Emerging Risks and the World Health Organization recently published reports which concluded that a large proportion of melanoma and non-melanoma skin cancer is attributable to sunbed use, and that there is no need to use sunbeds as there are no health benefits and they are not needed to achieve an optimal vitamin D level. The overall conclusion from both bodies was that there is no safe limit for UV irradiance from sunbeds. We are, however, deeply concerned that these assessments appear to be based on an incomplete, unbalanced and non-critical evaluation of the literature. Read More

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February 2018
4 Reads
1.870 Impact Factor

Iron-based radiochromic systems for UV dosimetry applications.

Phys Med Biol 2018 01 9;63(2):025010. Epub 2018 Jan 9.

Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, United States of America. The University of Texas MD Anderson Cancer Center, UTHealth Graduate School of Biomedical Sciences, Houston, TX, United States of America. Author to whom any correspondence should be addressed: The University of Texas MD Anderson Cancer Center, 1400 Pressler Street, Houston, TX 77030, United States of America.

Phototherapy treatment using ultraviolet (UV) A and B light sources has long existed as a treatment option for various skin conditions. Quality control for phototherapy treatment recommended by the British Association of Dermatologists and British Photodermatology Group generally focused on instrumentation-based dosimetry measurements. The purpose of this study was to present an alternative, easily prepared dosimeter system for the measurement of UV dose and as a simple quality assurance technique for phototherapy treatments. Read More

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January 2018
4 Reads

Unique profile of antimicrobial peptide expression in polymorphic light eruption lesions compared to healthy skin, atopic dermatitis, and psoriasis.

Photodermatol Photoimmunol Photomed 2018 Mar 13;34(2):137-144. Epub 2017 Nov 13.

Research Unit for Photodermatology, Medical University of Graz, Graz, Austria.

Background: Polymorphic light eruption (PLE) has been attributed to type IV, most likely delayed-type hypersensitivity response (adaptive immunity) but little is known on innate immunity, especially antimicrobial peptides (AMPs) in the disease. Abnormalities in AMP expression have been linked to pathological skin conditions such as atopic dermatitis (AD) and psoriasis.

Methods: Antimicrobial peptide profiling was carried out in PLE skin samples (n,12) compared with that of healthy (n,13), atopic (n,6), and psoriatic skin (n,6). Read More

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March 2018
7 Reads

Histological observation of hairless mice skin after exposure to Simulated Solar Light: Comparison between the histological findings with different methodologies and 3R principle correlations.

Burns 2018 03 9;44(2):359-369. Epub 2017 Oct 9.

Laboratório de Microbiologia e Avaliação Genotóxica, Departamento de Análises Clínicas e Toxicológicas, Faculdade de Farmácia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.

Background: Albino hairless mouse (AHM) has been used as a biological model in photodermatology. However, the experimental landscape is diverse to follow and need particular attention.

Purpose: Irradiation parameters were investigated for the development of a protocol to assess alterations in the AHM skin using Simulated Solar Light (SSL). Read More

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March 2018
6 Reads

Irradiance, as well as body site and timing of readings, is important in determining ultraviolet A minimal erythemal dose: reply from the authors.

Authors:
T Gambichler P Wolf

Br J Dermatol 2018 Jan 1;178(1):298-299. Epub 2017 Dec 1.

Research Unit for Photodermatology, Department of Dermatology, Medical University of Graz, Graz, Austria.

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January 2018

Chronic actinic dermatitis: successful treatment with psoralen-ultraviolet A photochemotherapy.

Br J Dermatol 2018 Mar 15;178(3):e189-e190. Epub 2018 Jan 15.

Photodermatology Unit, St John's Institute of Dermatology, London, U.K.

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March 2018
3 Reads

Solar urticaria developing in patients with erythropoietic protoporphyria: a clue to the pathogenesis of solar urticaria?

Br J Dermatol 2018 Feb 20;178(2):567-568. Epub 2018 Jan 20.

Photodermatology Department, St John's Institute of Dermatology, Guy's Hospital, London, SE1 9RH, U.K.

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February 2018
5 Reads

Daylight photodynamic therapy in Scotland.

Scott Med J 2017 May 16;62(2):48-53. Epub 2017 May 16.

6 Professor of Photodermatology, Head of Photobiology Unit, Clinical Director Scottish PDT Centre.

Chronic sun-induced dysplastic skin changes (actinic keratoses) are extremely common in fair-skinned people in Scotland. These changes are a major cause of morbidity and may develop into skin cancer. Actinic keratoses are often extensive and pose a therapeutic challenge as field-directed treatment is required for chronic disease management. Read More

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May 2017
9 Reads

Are very high cumulative doses of narrowband UVB safe in vitiligo?

Photodermatol Photoimmunol Photomed 2017 07 23;33(4):220-221. Epub 2017 May 23.

Department of Photodermatology, St John's Institute of Dermatology, Guy's and St Thomas' Hospital, London, UK.

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July 2017
7 Reads

16S Based Microbiome Analysis from Healthy Subjects' Skin Swabs Stored for Different Storage Periods Reveal Phylum to Genus Level Changes.

Front Microbiol 2016 20;7:2012. Epub 2016 Dec 20.

Research Unit for Photodermatology, Department of Dermatology, Medical University of Graz Graz, Austria.

Microbiome research and improvements in high throughput sequencing technologies revolutionize our current scientific viewpoint. The human associated microbiome is a prominent focus of clinical research. Large cohort studies are often required to investigate the human microbiome composition and its changes in a multitude of human diseases. Read More

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December 2016
6 Reads

Determination of the minimal erythema dose for ultraviolet A1 radiation.

Br J Dermatol 2017 Jul 8;177(1):238-244. Epub 2017 Jun 8.

Research Unit for Photodermatology, Department of Dermatology, Medical University of Graz, Graz, Austria.

Background: There is limited knowledge of the potential of ultraviolet A1 (UVA1) radiation to induce erythema.

Objectives: To investigate the minimal erythema dose (MED) for UVA1 in a German and Austrian population and to determine UVA1 dose-response curves for erythema and pigmentation.

Methods: We determined the UVA1-MED in 59 participants using a geometric increase in the dose. Read More

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Focus theme issue December 2016: Photobiology & photodermatology: "Photobiology first".

Exp Dermatol 2016 12;25(12):935-936

Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands.

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December 2016
1 Read

The Skin Microbiome: Is It Affected by UV-induced Immune Suppression?

Front Microbiol 2016 10;7:1235. Epub 2016 Aug 10.

Research Unit for Photodermatology, Department of Dermatology, Medical University of Graz Graz, Austria.

Human skin apart from functioning as a physical barricade to stop the entry of pathogens, also hosts innumerable commensal organisms. The skin cells and the immune system constantly interact with microbes, to maintain cutaneous homeostasis, despite the challenges offered by various environmental factors. A major environmental factor affecting the skin is ultraviolet radiation (UV-R) from sunlight. Read More

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August 2016
1 Read

Microbial elements as the initial triggers in the pathogenesis of polymorphic light eruption?

Exp Dermatol 2016 12;25(12):999-1001

Research Unit for Photodermatology, Department of Dermatology, Medical University of Graz, Graz, Austria.

The primary trigger of polymorphic light eruption (PLE) remains to be uncovered. We hypothesize that PLE may be initiated by elements resulting from UV-induced damage to microbial communities of the skin, leading to a cascade of events eventually resulting in the skin rash of the disease. One mechanism by which epidermal injury by UV radiation could trigger PLE are danger signals such as damage or pathogen associated molecular patterns DAMP/PAMPs or commensal-associated molecular patterns (CAMPs). Read More

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December 2016
1 Read

Desired response to phototherapy vs photoaggravation in psoriasis: what makes the difference?

Exp Dermatol 2016 12;25(12):937-944

Cellular Photoimmunology Group, Infectious Diseases and Immunology, Sydney Medical School, Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia.

Psoriasis commonly responds beneficially to UV radiation from natural sunlight or artificial sources. Therapeutic mechanisms include the proapoptotic and immunomodulating effects of UV, affecting many cells and involving a variety of pro- and anti-inflammatory cytokines, downregulating the Th17/IL-23 response with simultaneous induction of regulatory immune cells. However, exposure to UV radiation in a subset of psoriasis patients leads to exacerbation of the disease. Read More

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December 2016
2 Reads

Prospective Investigation of 25(OH)D3 Serum Concentration Following UVB Narrow Band Phototherapy in Patients with Psoriasis and Atopic Dermatitis.

Anticancer Res 2016 Mar;36(3):1439-44

Center for Clinical and Experimental Photodermatology, Department of Dermatology, The Saarland University Hospital, Homburg, Germany

Vitamin D deficiency represents a major health issue. It is a worldwide endemic and is associated with a broad variety of severe diseases. The skin is a key tissue for the human body's vitamin D endocrine system. Read More

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March 2016
4 Reads

Biologic Effects of Light: An Enlighting Prospective.

Anticancer Res 2016 Mar;36(3):1339-43

Section of Endocrinology, Diabetes and Nutrition, Department of Medicine, Boston University Medical Center, Boston, MA, U.S.A.

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March 2016
35 Reads

Ocular solar protection in xeroderma pigmentosum: the role of untinted lenses in blocking ultraviolet radiation.

Br J Dermatol 2016 Sep 30;175(3):625-7. Epub 2016 Jun 30.

National Xeroderma Pigmentosum Service, Department of Photodermatology, St John's Institute of Dermatology, Guy's and St Thomas' NHS Foundation Trust, London, SE1 7EH, U.K.

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September 2016

Serotonin signalling is crucial in the induction of PUVA-induced systemic suppression of delayed-type hypersensitivity but not local apoptosis or inflammation of the skin.

Exp Dermatol 2016 07 18;25(7):537-43. Epub 2016 Apr 18.

Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Psoralen and UVA (PUVA) has immunosuppressive and proapoptotic effects, which are thought to be responsible alone or in combination for its therapeutic efficacy. However, the molecular mechanism by which PUVA mediates its effects is not well understood. Activation of the serotonin (5-hydroxytryptamine, 5-HT) pathway has been suggested to be involved in the modulation of T-cell responses and found to mediate UVB-induced immune suppression. Read More

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July 2016
24 Reads
2 Citations
3.760 Impact Factor

Influence of the season on vitamin D levels and regulatory T cells in patients with polymorphic light eruption.

Photochem Photobiol Sci 2016 Mar 25;15(3):440-6. Epub 2016 Feb 25.

Research Unit for Photodermatology, Department of Dermatology, Medical University of Graz, Graz, Austria.

The exact mechanisms of photohardening in polymorphic light eruption (PLE) are still unknown, but medical photohardening was shown to increase regulatory T cell (Treg) numbers in the blood of PLE patients, similar to natural hardening. Furthermore, oral vitamin D supplementation increased peripheral Tregs in healthy individuals. We herein report on a post hoc analysis of 26 screened PLE patients of a clinical trial (ClinicalTrials. Read More

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Deep phenotyping of 89 xeroderma pigmentosum patients reveals unexpected heterogeneity dependent on the precise molecular defect.

Proc Natl Acad Sci U S A 2016 Mar 16;113(9):E1236-45. Epub 2016 Feb 16.

Genome Damage and Stability Centre, University of Sussex, Falmer, Brighton BN1 9RQ, United Kingdom;

Xeroderma pigmentosum (XP) is a rare DNA repair disorder characterized by increased susceptibility to UV radiation (UVR)-induced skin pigmentation, skin cancers, ocular surface disease, and, in some patients, sunburn and neurological degeneration. Genetically, it is assigned to eight complementation groups (XP-A to -G and variant). For the last 5 y, the UK national multidisciplinary XP service has provided follow-up for 89 XP patients, representing most of the XP patients in the United Kingdom. Read More

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March 2016
22 Reads

STAT3/5-Dependent IL9 Overexpression Contributes to Neoplastic Cell Survival in Mycosis Fungoides.

Clin Cancer Res 2016 07 5;22(13):3328-39. Epub 2016 Feb 5.

Research Unit for Photodermatology, Department of Dermatology and Venereology, Medical University of Graz, Graz, Austria.

Purpose: Sustained inflammation is a key feature of mycosis fungoides (MF), the most common form of cutaneous T-cell lymphoma (CTCL). Resident IL9-producing T cells have been found in skin infections and certain inflammatory skin diseases, but their role in MF is currently unknown.

Experimental Design: We analyzed lesional skin from patients with MF for the expression of IL9 and its regulators. Read More

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July 2016
3 Reads

A Distinct Genotype of XP Complementation Group A: Surprisingly Mild Phenotype Highly Prevalent in Northern India/Pakistan/Afghanistan.

J Invest Dermatol 2016 Apr 29;136(4):869-872. Epub 2015 Dec 29.

National Xeroderma Pigmentosum Service, Department of Photodermatology, St. John's Institute of Dermatology, Guy's and St. Thomas' NHS Foundation Trust, London, United Kingdom. Electronic address:

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April 2016
6 Reads
2 Citations
7.220 Impact Factor

Correction: Patients with polymorphic light eruption have decreased serum levels of 25-hydroxyvitamin-D(3) that increase upon 311 nm UVB photohardening.

Photochem Photobiol Sci 2016 Jan 21;15(1):129. Epub 2015 Dec 21.

Research Unit for Photodermatology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.

Correction for 'Patients with polymorphic light eruption have decreased serum levels of 25-hydroxyvitamin-D(3) that increase upon 311 nm UVB photohardening' by Peter Wolf et al., Photochem. Photobiol. Read More

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January 2016
5 Reads

Designing a broad-spectrum integrative approach for cancer prevention and treatment.

Authors:
Keith I Block Charlotte Gyllenhaal Leroy Lowe Amedeo Amedei A R M Ruhul Amin Amr Amin Katia Aquilano Jack Arbiser Alexandra Arreola Alla Arzumanyan S Salman Ashraf Asfar S Azmi Fabian Benencia Dipita Bhakta Alan Bilsland Anupam Bishayee Stacy W Blain Penny B Block Chandra S Boosani Thomas E Carey Amancio Carnero Marianeve Carotenuto Stephanie C Casey Mrinmay Chakrabarti Rupesh Chaturvedi Georgia Zhuo Chen Helen Chen Sophie Chen Yi Charlie Chen Beom K Choi Maria Rosa Ciriolo Helen M Coley Andrew R Collins Marisa Connell Sarah Crawford Colleen S Curran Charlotta Dabrosin Giovanna Damia Santanu Dasgupta Ralph J DeBerardinis William K Decker Punita Dhawan Anna Mae E Diehl Jin-Tang Dong Q Ping Dou Janice E Drew Eyad Elkord Bassel El-Rayes Mark A Feitelson Dean W Felsher Lynnette R Ferguson Carmela Fimognari Gary L Firestone Christian Frezza Hiromasa Fujii Mark M Fuster Daniele Generali Alexandros G Georgakilas Frank Gieseler Michael Gilbertson Michelle F Green Brendan Grue Gunjan Guha Dorota Halicka William G Helferich Petr Heneberg Patricia Hentosh Matthew D Hirschey Lorne J Hofseth Randall F Holcombe Kanya Honoki Hsue-Yin Hsu Gloria S Huang Lasse D Jensen Wen G Jiang Lee W Jones Phillip A Karpowicz W Nicol Keith Sid P Kerkar Gazala N Khan Mahin Khatami Young H Ko Omer Kucuk Rob J Kulathinal Nagi B Kumar Byoung S Kwon Anne Le Michael A Lea Ho-Young Lee Terry Lichtor Liang-Tzung Lin Jason W Locasale Bal L Lokeshwar Valter D Longo Costas A Lyssiotis Karen L MacKenzie Meenakshi Malhotra Maria Marino Maria L Martinez-Chantar Ander Matheu Christopher Maxwell Eoin McDonnell Alan K Meeker Mahya Mehrmohamadi Kapil Mehta Gregory A Michelotti Ramzi M Mohammad Sulma I Mohammed D James Morre Vinayak Muralidhar Irfana Muqbil Michael P Murphy Ganji Purnachandra Nagaraju Rita Nahta Elena Niccolai Somaira Nowsheen Carolina Panis Francesco Pantano Virginia R Parslow Graham Pawelec Peter L Pedersen Brad Poore Deepak Poudyal Satya Prakash Mark Prince Lizzia Raffaghello Jeffrey C Rathmell W Kimryn Rathmell Swapan K Ray Jörg Reichrath Sarallah Rezazadeh Domenico Ribatti Luigi Ricciardiello R Brooks Robey Francis Rodier H P Vasantha Rupasinghe Gian Luigi Russo Elizabeth P Ryan Abbas K Samadi Isidro Sanchez-Garcia Andrew J Sanders Daniele Santini Malancha Sarkar Tetsuro Sasada Neeraj K Saxena Rodney E Shackelford H M C Shantha Kumara Dipali Sharma Dong M Shin David Sidransky Markus David Siegelin Emanuela Signori Neetu Singh Sharanya Sivanand Daniel Sliva Carl Smythe Carmela Spagnuolo Diana M Stafforini John Stagg Pochi R Subbarayan Tabetha Sundin Wamidh H Talib Sarah K Thompson Phuoc T Tran Hendrik Ungefroren Matthew G Vander Heiden Vasundara Venkateswaran Dass S Vinay Panagiotis J Vlachostergios Zongwei Wang Kathryn E Wellen Richard L Whelan Eddy S Yang Huanjie Yang Xujuan Yang Paul Yaswen Clement Yedjou Xin Yin Jiyue Zhu Massimo Zollo

Semin Cancer Biol 2015 Dec;35 Suppl:S276-S304

Centro di Ingegneria Genetica e Biotecnologia Avanzate, Naples, Italy; Department of Molecular Medicine and Medical Biotechnology, Federico II, Via Pansini 5, 80131 Naples, Italy.

Targeted therapies and the consequent adoption of "personalized" oncology have achieved notable successes in some cancers; however, significant problems remain with this approach. Many targeted therapies are highly toxic, costs are extremely high, and most patients experience relapse after a few disease-free months. Relapses arise from genetic heterogeneity in tumors, which harbor therapy-resistant immortalized cells that have adopted alternate and compensatory pathways (i. Read More

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December 2015
41 Reads
28 Citations
9.330 Impact Factor

8-methoxypsoralen plus UVA (PUVA) therapy normalizes signalling of phosphorylated component of mTOR pathway in psoriatic skin of K5.hTGFβ1 transgenic mice.

Exp Dermatol 2015 Nov 15;24(11):889-91. Epub 2015 Sep 15.

Research Unit for Photodermatology, Department of Dermatology and Venereology, Medical University of Graz, Graz, Austria.

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November 2015
2 Reads

Photopatch testing in Bogota (Colombia): 2011-2013.

Contact Dermatitis 2016 Jan 18;74(1):11-7. Epub 2015 Jun 18.

Photodermatology Unit, Centro Dermatologico Federico Lleras Acosta (Colombian National Institute of Dermatology), 111511, Bogota D.C., Colombia.

Background: Photopatch tests are used to diagnose photoallergic contact dermatitis and identify the causal agents. The frequencies of positive results and associated allergens vary by country; therefore, it is necessary to know the information specific to each country.

Objective: To establish the frequency of positive photopatch test results, and their relevance, in patients with suspected photoallergic contact dermatitis in a national dermatology centre located in Bogota, Colombia. Read More

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January 2016

Levels and function of regulatory T cells in patients with polymorphic light eruption: relation to photohardening.

Br J Dermatol 2015 Aug 30;173(2):519-26. Epub 2015 Jul 30.

Research Unit for Photodermatology, Department of Dermatology, Medical University of Graz, Auenbrugger Platz 8, A-8036, Graz, Austria.

Background: We hypothesized that regulatory T cells (Tregs) are involved in the immunological abnormalities seen in patients with polymorphic light eruption (PLE).

Objectives: To investigate the number and suppressive function of peripheral Tregs in patients with PLE compared with healthy controls.

Methods: Blood sampling was done in 30 patients with PLE [seeking or not seeking 311-nm ultraviolet (UV)B photohardening] as well as 19 healthy controls at two time points: TP1, March to June (before phototherapy); and TP2, May to August (after phototherapy). Read More

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August 2015
1 Read

Methyl aminolevulinate photodynamic therapy for actinic keratosis does not affect peripheral regulatory T-cell level or function.

Photodermatol Photoimmunol Photomed 2015 Sep 20;31(5):274-8. Epub 2015 Apr 20.

Research Unit for Photodermatology, Department of Dermatology, Medical University of Graz, Graz, Austria.

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September 2015

Mast cells are required for phototolerance induction and scratching abatement.

Exp Dermatol 2015 Jul 16;24(7):491-6. Epub 2015 Apr 16.

Research Unit for Photodermatology, Department of Dermatology, Medical University of Graz, Graz, Austria.

Dermal mast cells protect the skin from inflammatory effects of ultraviolet (UV) radiation and are required for UV-induced immune suppression. We sought to determine a potential mechanistic role of mast cells in reducing the sensitivity to UV radiation (i.e. Read More

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July 2015
8 Reads
5 Citations
3.760 Impact Factor

Psoriasis Area and Severity Index 75 rate of classical inpatient dithranol therapy under daily life conditions.

Br J Dermatol 2015 Sep 22;173(3):815-7. Epub 2015 Jul 22.

Research Unit for Photodermatology, Department of Dermatology, Medical University of Graz, Auenbrugger Platz 8, A-8036, Graz, Austria.

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September 2015

Topical monobenzyl ether of hydroquinone is an effective and safe treatment for depigmentation of extensive vitiligo in the medium term: a retrospective cohort study of 53 cases.

Authors:
E S-T Tan R Sarkany

Br J Dermatol 2015 Jun 27;172(6):1662-4. Epub 2015 Apr 27.

Photodermatology Unit, St John's Institute of Dermatology, London, U.K.

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June 2015
6 Reads

Photodermatology over the past 125 years.

Authors:
R Roelandts

Br J Dermatol 2014 Nov;171(5):926-8

Photodermatology Unit, University Hospital St Rafael, Kapucijnenvoer 33, B-3000, Leuven, Belgium.

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November 2014
1 Read

[Section on photodermatology ].

J Dtsch Dermatol Ges 2014 Nov;12 Suppl 4:63-4

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November 2014
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