Search Our Scientific Publications & Authors

Proc (Bayl Univ Med Cent) 2022 22;35(4):526-528. Epub 2022 Mar 22.

Department of Radiology, Baylor University Medical Center, Dallas, Texas.

A 39-year-old woman presented with chest pain and elevated troponin levels. Cardiac catheterization demonstrated no coronary artery disease, with findings consistent with atypical variant takotsubo cardiomyopathy. Further workup showed elevated plasma fractionated metanephrines suggestive of pheochromocytoma. Read More

BJS Open 2022 May;6(3)

Department of Anaesthesia, University of Glasgow, Glasgow, UK.

Introduction: Phaeochromocytomas are rare tumours with a recurrence after open surgery ranging between 6-23 per cent. Long-term follow-up studies after laparoscopic surgery for phaeochromocytoma are lacking. The aim of this study was to look at the long-term oncological outcome of a consecutive series of patients from a single centre undergoing laparoscopic surgery for a phaeochromocytoma. Read More

Medicina (Kaunas) 2022 May 30;58(6). Epub 2022 May 30.

Department of Endocrinology and Internal Medicine, Faculty of Medicine, Medical University of Gdansk, 80-214 Gdansk, Poland.

The current high detection rate of adrenal tumors (4-10% of general population) is attributable to a widespread use of variety of imaging studies, especially a computed tomography. Most of them represent clinically silent and biologically indolent incidentalomas, but some adrenal tumors may pose a significant clinical challenge. Thus, in every patient with an adrenal tumor, a decision on further management is made after careful hormonal and radiological evaluation. Read More

Endocr Relat Cancer 2022 Jun 1. Epub 2022 Jun 1.

J Chan, GI oncology, Dana Farber Cancer Center, Boston, 02215, United States.

Malignant pheochromocytomas/paragangliomas are rare tumors for which clinical outcomes remain poorly defined and therapeutic options are limited. Approximately 27% carry pathogenic germline succinate dehydrogenase (SDHx) mutations; the presence of such mutations has been correlated with response to temozolomide. We aimed to investigate the association between SDHx and response to temozolomide. Read More

PET Clin 2022 Jul;17(3):343-367

Radiation Medicine Centre (B.A.R.C), Tata Memorial Centre Annexe, Parel, Mumbai, India; Homi Bhabha National Institute, Mumbai, India. Electronic address:

Endocrine neoplasms and malignancies are a diverse group of tumors with varied clinical, histopathologic, and functional features. These tumors vary from sporadic to hereditary, isolated entities to multiple neoplastic syndromes, functioning and non functioning tumors, unifocal locally invasive, and advanced to multifocal tumors with disseminated distant metastases. The presence of various specific biomarkers and specific receptor targets serves as valuable tools for diagnosis, prognosis, and management. Read More

Med Glas (Zenica) 2022 Aug 1;19(2). Epub 2022 Aug 1.

School of Medicine, J. J. Strossmayer University, Osijek, Croatia.

Pheochromocytoma is a rare cause of hypertension in pregnancy. Unrecognized, it carries a great risk for both mother and the foetus. The main reason for missing the diagnosis is the misconception that any hypertension occurring in pregnancy is gestational hypertension or pre (eclampsia). Read More

J Med Vasc 2022 Apr 20;47(2):106-108. Epub 2022 May 20.

Internal medicine and Cardiology Department, University of Blida 1, University hospital of Douéra, Douéra, Algeria. Electronic address:

We are reporting a case revealed by an abdomino-thoracic painful syndrome associated with multi-organ failure. A 61-year-old hypertensive woman was hospitalized for the management of hypertensive emergency associating acute coronary syndrome and abdominal pain. A thoraco-abdomino-pelvic CT-scan showed a right adrenal mass associated with hepatic vein thrombosis. Read More

Eur Radiol 2022 Jun 9. Epub 2022 Jun 9.

Department of Medical Imaging, The Ottawa Hospital, University of Ottawa, 1053 Carling Avenue, C1 Radiology, Ottawa, Ontario, K1Y 4E9, Canada.

Objectives: To evaluate the T2-weighted (T2W) MRI calculator to differentiate adrenal pheochromocytoma from lipid-poor adrenal adenoma.

Methods: Twenty-nine consecutive pheochromocytomas resected between 2010 and 2019 were compared to 23 consecutive lipid-poor adrenal adenomas. Three blinded radiologists (R1, R2, R3) subjectively evaluated T2W signal intensity and heterogeneity and extracted T2W signal intensity ratio (SIR) and entropy. Read More

World J Surg Oncol 2022 Jun 8;20(1):185. Epub 2022 Jun 8.

Department of Gastroenterological Surgery, Saitama Cancer Center, Saitama, 362-0806, Japan.

Background: Paraganglioma of the urinary bladder (Pub) is rare and presents with clinical symptoms caused by catecholamine production and release. The typical symptoms of Pub are hypertension, macroscopic hematuria, and a hypertensive crisis during micturition. The average size of detected Pubs is approximately 3 cm. Read More

Nuklearmedizin 2022 Jun 3;61(3):231-239. Epub 2022 Jun 3.

Nuclear Medicine, Kanazawa University Hospital, Kanazawa, Japan.

Aim: Pheochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine tumours of chromaffin cells. Several modalities are currently available to treat patients with PPGL. These treatment modalities include surgery, chemotherapy, molecular targeted therapy and radiopharmaceuticals. Read More

Cureus 2022 Apr 29;14(4):e24584. Epub 2022 Apr 29.

Internal Medicine, Hamad Medical Corporation, Doha, QAT.

Pheochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine tumors with diverse clinical presentations. Pathogenic variants in the genes encoding different subunits of the succinate dehydrogenase enzyme complex that plays a central role in energy metabolism have been linked to hereditary PPGL syndromes. Here we report a rare case of hereditary pheochromocytoma with a novel mutation in the succinate dehydrogenase subunit A () gene. Read More

Indian J Endocrinol Metab 2022 Jan-Feb;26(1):73-78. Epub 2022 Apr 27.

Department of Endocrinology, Gauhati Medical College and Hospital, Guwahati, Assam, India.

Context: Adrenal incidentalomas (AIs) are seen in around 2% of apparently healthy individuals. These require careful evaluation for the hormone excess state and the presence of malignancy prior to intervention.

Aims: To study the clinical, biochemical, and imaging characteristics of the patients with AI and correlate the diagnosis with the histopathology findings in patients undergoing surgery. Read More

Medicina (Kaunas) 2022 Apr 27;58(5). Epub 2022 Apr 27.

Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.

: Adrenal incidentaloma is an adrenal mass that is found incidentally in abdominal imaging studies. It is important to categorize whether the mass is a functioning or non-functioning incidentaloma to determine the appropriate management and follow-up. Our study aimed to identify predictive factors for functioning adrenal incidentaloma that could assist in early detection and in determining which patients may require hormonal investigations. Read More

J Nucl Med 2022 May 26. Epub 2022 May 26.

National Institute of Health, United States.

Endocrine 2022 May 23. Epub 2022 May 23.

Department of Endocrinology, Chinese People's Liberation Army General Hospital, Beijing, China.

Purpose: To investigate the clinical characteristics, endocrinological function, and etiology of bilateral adrenal lesions in hospitalized patients.

Methods: A retrospective study of 777 patients with bilateral adrenal lesions was conducted at the Chinese People's Liberation Army General Hospital between January 2013 and January 2018. Patients' demographic features, hormonal profiles, imaging findings, and histopathological findings were reviewed from database records. Read More

Int J Surg Case Rep 2022 Jun 22;95:107119. Epub 2022 Apr 22.

Department of Surgery, Hospital Universitario Fundación Santa Fe de Bogotá, 110111, Bogotá D.C., Colombia; School of Medicine, Universidad de los Andes, 111711 Bogotá D.C., Colombia.

Introduction: Paraganglioma and pheochromocytoma are uncommon conditions that affect around 1.5-9 patients per million. The most frequent symptoms are headache, hypertension and diaphoresis; however, palpitations or tachycardia could be present. Read More

J Clin Med 2022 May 5;11(9). Epub 2022 May 5.

Department of Oncology and Radiotherapy, Medical University of Gdansk, 80-214 Gdansk, Poland.

Paraganglioma and pheochromocytoma are rare medical conditions. Thus, there are still a small number of studies, clinical trials, and evidence-based data in this field. This makes clinical decisions more difficult. Read More

J Clin Endocrinol Metab 2022 May 10. Epub 2022 May 10.

Section on Medical Neuroendocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Building 10, CRC, Room 1E-3140, 10 Center Drive MSC-1109, Bethesda, Maryland 20892-1109, US.

Abdom Radiol (NY) 2022 Jul 10;47(7):2453-2461. Epub 2022 May 10.

Department of Medical Imaging, The Ottawa Hospital, University of Ottawa, 1053 Carling Avenue, C1 Radiology, Ottawa, ON, K1Y 4E9, Canada.

Objective: To compare diagnostic accuracy of washout (WO)-CT to chemical shift (CS)-MRI + T2W adrenal MRI Calculator (T2W-Calculator) to diagnose adrenal adenoma in indeterminate adrenal masses.

Methods: This retrospective, cross-sectional, non-inferiority study evaluated 40 consecutive indeterminate adrenal masses; each with WO-CT and MRI. Two blinded radiologists independently evaluated in mixed order: pre-contrast attenuation (Hounsfield Units, HU) and absolute WO ([Peak. Read More

Eur J Nucl Med Mol Imaging 2022 May 6. Epub 2022 May 6.

Department of Nuclear Medicine, The Affiliated Hospital of Southwest Medical University, No. 25 Taiping St., Jiangyang DistrictSichuan, Luzhou, 646000, People's Republic of China.

World J Nucl Med 2022 Mar 30;21(1):73-75. Epub 2022 Apr 30.

Department of Endocrinology, Yashoda Hospital, Secunderabad, Telangana, India.

Pheochromocytoma is a rare catecholamine secreting neuroendocrine tumor arising from chromaffin cells of adrenal medulla with approximate prevalence of 0.1 to 0.6% in patients suffering from hypertension. Read More

Presse Med 2022 Apr 29:104124. Epub 2022 Apr 29.

Service de Médecine Nucléaire, Gustave Roussy Cancer Campus, 114, rue Édouard-Vaillant 94805 Villejuif Cedex, France. Electronic address:

Over the past twenty years, nuclear medicine has enhanced the role of functional imaging in cancerology. A major milestone was achieved in the early 2000s with widespread availability of the positron emitter tracer 18F- deoxyglucose (FDG) and the introduction of hybrid imagers, i.e. Read More

Front Oncol 2022 13;12:879714. Epub 2022 Apr 13.

Department of Emergency, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, People's Hospital of Henan University, Zhengzhou, China.

Pheochromocytoma is a rare catecholamine-secreting tumor with highly variable clinical presentations. We herein report a patient who presented to the emergency department with precordia pain, elevated myocardial enzymes, T-wave inversions on electrocardiogram and segmental ventricular wall motion abnormalities on echocardiography, which is normally managed as suspected acute coronary syndrome (ACS). However, the urgent coronary angiography showed normal coronary arteries. Read More

Pediatr Blood Cancer 2022 Aug 29;69(8):e29740. Epub 2022 Apr 29.

Department of Radiology, Boston Children's Hospital, Boston, USA.

Pheochromocytoma and paraganglioma (PPGL) are rare neuroendocrine tumors in childhood. Up to 40% of PPGL are currently thought to be associated with a hereditary predisposition. Nuclear medicine imaging modalities such as fluorodeoxyglucose positron emission tomography ( F-FDG PET), Ga-DOTATATE PET, and I-metaiodobenzylguanidine ( I-MIBG) scintigraphy play an essential role in the staging, response assessment, and determination of suitability for targeted radiotherapy in patients with PPGL. Read More

Anal Chem 2022 05 22;94(17):6441-6445. Epub 2022 Apr 22.

Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (MOE), School of Pharmacy, Shandong University, Jinan, Shandong 250012, China.

As a neurotransmitter, norepinephrine (NE) is critical for psychiatric conditions, neurodegenerative diseases, and pheochromocytoma. A real-time and noninvasive method for the detection of NE as a tracer to investigate the NE-relevant disease treatment process is urgently desirable. Herein, we successfully developed a turn-on NE bioluminescent probe (NBP), which was grounded on -toluenethiol deprotectrf by nucleophilic substitution. Read More

Clin Endocrinol (Oxf) 2022 Apr 21. Epub 2022 Apr 21.

Division of Endocrinology, Diabetes, and Nutrition, Mayo Clinic, Rochester, Minnesota, USA.

Objective: Cystic adrenal mass is a rare imaging presentation of pheochromocytoma. We aimed to describe the clinical, biochemical and imaging characteristics of patients with cystic pheochromocytoma.

Design: Single-centre, retrospective study, 2000-2020. Read More

Anatol J Cardiol 2022 04;26(4):325-327

Department of Cardiology, A.O.U. "San Giovanni di Dio e Ruggi D'Aragona", Salerno, Italy.

Front Endocrinol (Lausanne) 2022 21;13:833413. Epub 2022 Mar 21.

Department of Diagnostic Radiology, City of Hope National Medical Center, Los Angeles, CA, United States.

Objectives: To assess the accuracy of computed tomography (CT)-based machine learning models for differentiating subclinical pheochromocytoma (sPHEO) from lipid-poor adenoma (LPA) in patients with adrenal incidentalomas.

Patients And Methods: The study included 188 tumors in the 183 patients with LPA and 92 tumors in 86 patients with sPHEO. Pre-enhanced CT imaging features of the tumors were evaluated. Read More

Clin Pharmacol Ther 2022 Apr 3. Epub 2022 Apr 3.

Department of Radiology, Section of Nuclear Medicine, Leiden University Medical Center, Leiden, The Netherlands.

The combined use of diagnostic and therapeutic radioligands with the same molecular target, also known as theranostics, enables accurate patient selection, targeted therapy, and prediction of treatment response. Radioiodine, bone-seeking radioligands and norepinephrine analogs have been used for many years for diagnostic imaging and radioligand therapy of thyroid carcinoma, bone metastases, pheochromocytoma, paraganglioma, and neuroblastoma, respectively. In recent years, radiolabeled somatostatin analogs and prostate-specific membrane antigen ligands have shown clinical efficacy in the treatment of neuroendocrine tumors and prostate cancer, respectively. Read More

Eur Heart J Case Rep 2022 Mar 7;6(3):ytac098. Epub 2022 Mar 7.

Department of Cardiology, Institute for Clinical and Experimental Medicine, Vídeňská 1958/9, Prague, Czech Republic.

Background: Pheochromocytoma is a neuroendocrine tumour originating from the chromaffin cells of adrenal glands or sympathetic paraganglia. It produces most frequently norepinephrine, epinephrine, and dopamine. As a result of non-specific and variable clinical presentation, pheochromocytoma is difficult to diagnose. Read More