21,488 results match your criteria Pheochromocytoma


Primary malignant tumors of the adrenal glands.

Clinics (Sao Paulo) 2018 Dec 10;73(suppl 1):e756s. Epub 2018 Dec 10.

Unidade de Suprarrenal, Laboratorio de Hormonios e Genetica Molecular LIM/42, Servico de Endocrinologia e Metabologia, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR.

Malignancy must be considered in the management of adrenal lesions, including those incidentally identified on imaging studies. Adrenocortical carcinomas (ACCs) are rare tumors with an estimated annual incidence of 0.7-2 cases per year and a worldwide prevalence of 4-12 cases per million/year. Read More

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December 2018

Procyanidins Extracted from Lotus Seedpod Ameliorate Amyloid--Induced Toxicity in Rat Pheochromocytoma Cells.

Oxid Med Cell Longev 2018 28;2018:4572893. Epub 2018 Oct 28.

Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.

Alzheimer's disease (AD) is a progressive neurodegenerative disease, which is characterized by extracellular senile plaque deposits, intracellular neurofibrillary tangles, and neuronal apoptosis. Amyloid- (A) plays a critical role in AD that may cause oxidative stress and downregulation of CREB/BDNF signaling. Anti-A effect has been discussed as a potential therapeutic strategy for AD. Read More

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October 2018

Radiomics improves efficiency for differentiating subclinical pheochromocytoma from lipid-poor adenoma: a predictive, preventive and personalized medical approach in adrenal incidentalomas.

EPMA J 2018 Dec 21;9(4):421-429. Epub 2018 Sep 21.

7Department of Radiology, Keck Medical Center of USC, Los Angeles, CA USA.

Objectives: This study aims to define a radiomic signature for pre-operative differentiation between subclinical pheochromocytoma (sPHEO) and lipid-poor adrenal adenoma (LPA) in adrenal incidentaloma. The goal was to apply a predictive, preventive, and personalized medical approach to the management of adrenal tumors.

Patients And Methods: This retrospective study consisted of 265 consecutive patients (training cohort, 212 (LPA, 145; sPHEO, 67); validation cohort, 53 (LPA, 36; sPHEO, 17)). Read More

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December 2018

Update of Pheochromocytoma Syndromes: Genetics, Biochemical Evaluation, and Imaging.

Front Endocrinol (Lausanne) 2018 27;9:515. Epub 2018 Nov 27.

Section on Medical Neuroendocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, United States.

Pheochromocytomas and paragangliomas (PCCs/PGLs) are rare commonly benign neuroendocrine tumors that share pathology features and clinical behavior in many cases. While PCCs are chromaffin-derived tumors that arise within the adrenal medulla, PGLs are neural-crest-derived tumors that originate at the extraadrenal paraganglia. Pheochromocytoma-paraganglioma (PPGL) syndromes are rapidly evolving entities in endocrinology and oncology. Read More

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November 2018

Rare cause of ventricular tachycardia: Pheochromocytoma.

J Cardiol Cases 2015 Feb 14;11(2):62-65. Epub 2014 Nov 14.

Department of Cardiology, Aalborg University Hospital, Hobrovej 18-22, 9000 Aalborg, Denmark.

Pheochromocytoma is known from a wide range of clinical manifestations and can mimic other disorders which can lead to delay in diagnosis. We report a case of a young female presenting with chest pain, electrocardiographic changes, and episodes of ventricular tachycardia, finally diagnosed with this catecholamine-producing tumor. < Pheochromocytoma is a rare catecholamine-producing tumor that can pose a diagnostic challenge due to its multiple manifestations mimicking various conditions, including cardiovascular disorders. Read More

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February 2015

Is exercise-related QT interval shortening with a peaked T wave a specific electrocardiographic finding of pheochromocytoma?

J Cardiol Cases 2013 Apr 7;7(4):e117-e118. Epub 2013 Mar 7.

Division of Cardiovascular Medicine, Kanazawa University Graduate School of Medical Science, 13-1 Takara-machi, Kanazawa, Ishikawa 920-8640, Japan.

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Exercise-related QT interval shortening with a peaked T wave in a boy with MEN 2 syndrome.

J Cardiol Cases 2013 Apr 1;7(4):e93-e96. Epub 2012 Dec 1.

Department of Cardiology, Bayindir Hospital, Ankara, Turkey.

Multiple endocrine neoplasia 2 (MEN 2) is a hereditary syndrome associated with medullary thyroid carcinoma, pheochromocytoma (PCC), and hyperparathyroidism. PCCs in patients with MEN 2 are usually found in the adrenals after the manifestation of medullary thyroid cancer and are commonly bilateral and hormonally active. Unfortunately, a diagnosis of MEN 2 or PCC often is delayed until after the patient has developed an advanced MEN 2-related tumor. Read More

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Genetic testing and surveillance guidelines in hereditary pheochromocytoma and paraganglioma.

J Intern Med 2018 Dec 8. Epub 2018 Dec 8.

Clinical Genetics, Karolinska University Hospital, 171 76, Stockholm.

Pheochromocytomas (PCC) and paragangliomas (PGL), collectively abbreviated PPGL are rare tumours originating from the chromaffin cells in the adrenal medulla (PCC) or the sympathetic or parasympathetic extra-adrenal paraganglia (PGL) (1, 2), Figure 1. The enlarged cell volume leads to increased levels of catecholamines (adrenaline, noraderenaline and/or dopamine) and their metabolites which can be measured in plasma or urine for biochemical diagnosis. Hormone-producing PPGL commonly originate from sympathetic paraganglia in the adrenal glands, abdomen or pelvis (3). Read More

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December 2018
2 Reads

Variable somatostatin receptor subtype expression in 151 primary pheochromocytomas and paragangliomas.

Hum Pathol 2018 Dec 7. Epub 2018 Dec 7.

Department of Pathology, University of Helsinki and HUSLAB, Helsinki University Hospital, Haartmaninkatu 3, (P.O. Box 21, ), FIN-00014 University of Helsinki, Helsinki, Finland.

Pheochromocytomas (PHEOs) and paragangliomas (PGLs) are neuroendocrine tumors (NETs) that express somatostatin receptors (SSTRs), a phenomenon that constitutes a basis for tumor imaging and treatment with somatostatin analogues and Peptide Receptor Radionuclide Therapy (PRRT). We studied the immunohistochemical expression of SSTR1-5 in 151 primary tumors, including 14 metastasized and 16 SDHB-deficient tumors. SSTR2 and SSTR3 were most abundantly present in these tumors, whereas the tumors were mostly negative for SSTR1, SSTR4 and SSTR5. Read More

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December 2018

Tenofovir Disoproxil Fumarate induces Pheochromocytoma cells apoptosis.

Eur J Pharmacol 2018 Dec 6. Epub 2018 Dec 6.

Laboratory of Cancer Biomarkers and Liquid Biopsy, Pharmaceutical College of Henan University, Kaifeng, Henan, 475004, China. Electronic address:

Despite the triumph of highly active antiretroviral therapy (HAART) in anti-HIV infection, more than half of the HIV infection individuals receiving antiretroviral therapy acquire HIV-associated neurocognitive disorder (HAND). Previously researches had reported that the HAART neurotoxicity is implicated in HAND-related morbidity. The molecular mechanism of HAND is not clear. Read More

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December 2018

Risk factors for postoperative cardiovascular morbidity after pheochromocytoma surgery: a large single center retrospective analysis.

Endocr J 2018 Dec 4. Epub 2018 Dec 4.

Department of Urology, ShengJing Hospital of China Medical University, Shenyang 110004, China.

Surgical resection is the primary treatment strategy for pheochromocytoma; however, it carries a high risk of morbidity and mortality, especially with respect to cardiovascular complications, which is the most common kinds of morbidity. The risk factors for morbidity remain unclear and require further exploration, moreover no studies focus on risk factors for cardiovascular morbidity. Herein we identified the risk factors for cardiovascular morbidity after pheochromocytoma surgery in Chinese patients. Read More

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December 2018

Pheochromocytoma - An incidental finding in a child with acute appendicitis.

J Pak Med Assoc 2018 Dec;68(12):1854-1858

Jinnah Sindh Medical University, Karachi.

Pheochromocytoma, a rare tumour, arises mainly in the adrenal gland. It consists of chromaffin cells or sympathetic para-ganglia if extra-adrenal. It is an occurrence of rare nature with an incidence of two to eight cases per million annually. Read More

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December 2018
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Comparison of transperitoneal laparoscopic versus open adrenalectomy for large pheochromocytoma: A retrospective propensity score-matched cohort study.

Int J Surg 2018 Nov 29;61:26-32. Epub 2018 Nov 29.

Department of Urology, Shengjing Hospital of China Medical University, Shenyang 110004, China. Electronic address:

Background: Surgical resection is the main treatment strategy for pheochromocytoma. Whether laparoscopic techniques are feasible for large pheochromocytoma treatments is controversial. The aim of this study was to evaluate the feasibility and safety of transperitoneal laparoscopic adrenalectomy (LA) compared with open adrenalectomy (OA). Read More

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November 2018
1 Read

Ruptured Abdominal Aortic Aneurysm with a Suprarenal Tumor.

Braz J Cardiovasc Surg 2018 Sep-Oct;33(5):522-524

Department of Cardiovascular Surgery, Muş State Hospital, Muş, Turkey.

This paper presents a case study of a patient that underwent surgery for a ruptured abdominal aneurysm. The postoperative course was complicated by resistant hypertension and tachycardia. A suprarenal mass was detected in the computed tomography scan with radiological suspicion of pheochromocytoma. Read More

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August 2017
4 Reads

Pediatric total fractionated metanephrine. Age-related reference intervals in spot urine.

Minerva Pediatr 2018 Dec 3. Epub 2018 Dec 3.

Department of Laboratory Medicine and Pathology, Azienda USL of Modena, Modena, Italy.

Background: Sparse metanephrines reference intervals in pediatric populations are available and different study designs and technologies/ assays used in these studies lead to hardly transferable data from a laboratory to another. The objective of the study was to update pediatric reference intervals of total fractionated metanephrines in spot urine samples, using a commercial extraction kit run on a specific high pressure liquid chromatograph coupled with an electrochemical detector.

Methods: 452 spot pediatric urinary samples previously submitted to urinalysis were consecutively included in the study with the exclusion of children's samples with diagnosis or clinical suspicion of paraganglioma/pheochromocytoma, kidney diseases and arterial hypertension. Read More

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December 2018
3 Reads

Octreotide reverses shock due to vasoactive intestinal peptide-secreting adrenal pheochromocytoma: A case report and review of literature.

World J Clin Cases 2018 Nov;6(14):862-868

Department of Emergency Medicine, Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning Province, China.

Vasoactive intestinal peptide-producing tumors (VIPoma) usually originate in the pancreas and are characterized by diarrhea, hypokalemia, and achlorhydria (WDHA syndrome). In adults, nonpancreatic VIPoma is very rare. Herein, we report an unusual case of VIP-producing pheochromocytoma marked by persistent shock, flushing, and watery diarrhea and high sensitivity to octreotide. Read More

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November 2018
1 Read

Inhibition of ROS-mediated activation Src-MAPK/AKT signaling by orientin alleviates HO-induced apoptosis in PC12 cells.

Drug Des Devel Ther 2018 16;12:3973-3984. Epub 2018 Nov 16.

Anhui Province Key Laboratory of Active Biological Macro-molecules, Wannan Medical College, Wuhu 241002, People's Republic of China,

Purpose: Reactive oxygen species (ROS) are considered a direct cause of neurodegenerative diseases (NDDs). Drugs developed to target ROS are effective for the treatment of NDDs. Orientin is a pyrone glucoside extracted from , and it exhibits many pharmacological activities. Read More

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November 2018
1 Read

The role of ceramide and SEW 2871 in the transcription of enzymes involved in amyloid b precursor protein metabolism in an experimental model of Alzheimer's disease.

Folia Neuropathol 2018 ;56(3):196-205

Alzheimer's disease (AD) is characterized by alterations of amyloid precursor protein (APP) metabolism, accumulation of amyloid  peptides (A), hyperphosphorylation of Tau proteins and also by sphingolipids disturbances. These changes lead to oxidative stress, mitochondria dysfunction, synaptic loss and neuro-inflammation. It is known that A may promote ceramides formation and reversely, ceramides could stimulate A peptides release. Read More

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January 2018

Protective effect of Schisandra chinensis lignans on hypoxia-induced PC12 cells and signal transduction.

J Toxicol Environ Health A 2018 28;81(24):1224-1230. Epub 2018 Nov 28.

b Institute of Neuroscience , Department of Anatomy, Baotou Medical College , Inner Mongolia , China.

It is well-known that hypoxia induces neuronal injury; however, the mechanisms underlying this observed effect remain to be determined. Schisandra chinensis lignans (SCL). The aim of this study was thus to examine the ability of Schisandra chinensis lignans (SCL) to prevent hypoxia-induced neuronal injury using a human adrenal pheochromocytoma cell line (PC12). Read More

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November 2018

SDHx gene detection and clinical Phenotypic analysis of multiple paraganglioma in the head and neck.

Laryngoscope 2018 Nov 28. Epub 2018 Nov 28.

Department of Otolaryngology, Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, People's Republic of China.

Objectives: The goal of this study was to detect and explore the mechanisms of the succinate dehydrogenase (SDH) complex subunit-related gene mutations in cases of multiple paraganglioma (PGL) in the head and neck.

Methods: In Beijing Tongren Hospital (Capital Medical University, Beijing, People's Republic of China) between January 2013 and February 2017, 23 cases of head and neck multiple PGL were evaluated by genetic sequencing. From these cases, four hereditary families and 10 cases with sporadic occurrences were found. Read More

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November 2018
1 Read

Malignant Pheochromocytoma with Widespread Bony and Pulmonary Metastases.

Cureus 2018 Sep 24;10(9):e3348. Epub 2018 Sep 24.

Cardiothoracic Surgery, The Aga Khan University Hospital, Karachi, PAK.

Pheochromocytoma is a rare benign tumor of the adrenal gland. A select few cases may be malignant, and metastatic cases are exceedingly rare. It often presents with symptoms of catecholamine excess, such as sweating, palpitations, headaches, and characteristic paroxysmal hypertension. Read More

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September 2018
2 Reads

Radiofrequency radiation at 2.856 GHz does not affect key cellular endpoints in neuron-like PC12 cells.

Electromagn Biol Med 2018 Nov 27:1-9. Epub 2018 Nov 27.

a Department of Experimental Pathology , Beijing Institute of Radiation Medicine , Beijing P. R. China.

To investigate the potential cytotoxicity of radiofrequency (RF) radiation on central nervous system, rat pheochromocytoma (PC12) cells were exposed to 2.856 GHz RF radiation at a specific absorption rate (SAR) of 4 W/kg for 8 h a day for 2 days in 35 mm Petri dishes. During exposure, the real-time variation of the culture medium temperature was monitored in the first hour. Read More

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November 2018
1 Read

[French ccAFU guidelines - Update 2018-2020: Adrenal cancer].

Prog Urol 2018 Nov 27;28(12S):S175-S193. Epub 2018 Oct 27.

Service d'urologie, hôpital d'instruction des armées Sainte-Anne, BP 600, 83800 Toulon cedex 09, France; Service d'urologie, hôpital européen Georges-Pompidou, université Paris Descartes, AP-HP, 75015 Paris, France. Electronic address:

Objective: To update French oncology guidelines concerning adrenal cancer.

Methods: Comprehensive Medline search between 2016 and 2018 upon diagnosis, treatment and follow-up of adrenal cancer to update 2013 guidelines. Level of evidence was evaluated according to AGREE-II. Read More

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November 2018
4 Reads

Risk factors for postoperative severe morbidity after pheochromocytoma surgery: A single center retrospective analysis of 262 patients.

Int J Surg 2018 Nov 20;60:188-193. Epub 2018 Nov 20.

Department of Urology, ShengJing Hospital of China Medical University, Shenyang, 110004, China. Electronic address:

Purpose: Surgical resection is the primary treatment strategy for pheochromocytoma; however, it carries a high risk of morbidity and mortality. The risk factors for severe morbidity remain unclear and require further exploration. We aimed to identify the risk factors for severe morbidity after pheochromocytoma surgery in Chinese patients. Read More

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November 2018
1 Read

Incidence and predictive factors of hypoglycemia after pheochromocytoma resection.

Int J Urol 2018 Nov 22. Epub 2018 Nov 22.

Department of Urology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.

Objectives: To determine the incidence and preoperative risk factors of post-excisional hypoglycemia in patients undergoing pheochromocytoma resection.

Methods: Patients who underwent surgical resection of pheochromocytoma at a single institution were retrospectively enrolled in the present study. The primary end-point was the development of post-excisional hypoglycemia; that is, a serum glucose level <70 mg/dL. Read More

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November 2018
8 Reads

Pheochromocytoma Characteristics and Behavior Differ Depending on Method of Discovery.

J Clin Endocrinol Metab 2018 Nov 19. Epub 2018 Nov 19.

Division of Endocrinology, Diabetes, and Nutrition, Mayo Clinic, Rochester, MN, USA.

Context: Modern pheochromocytomas (PHEO) are often discovered by incidental finding on cross-sectional imaging or mutation-based genetic case detection testing. Little information is known about how these PHEO behave.

Objective: To describe the characteristics and behavior of PHEO discovered incidentally on imaging or through mutation-based genetic case detection testing. Read More

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November 2018
3 Reads

An update on adrenal endocrinology: significant discoveries in the last 10 years and where the field is heading in the next decade.

Hormones (Athens) 2018 Nov 19. Epub 2018 Nov 19.

Section on Endocrinology and Genetics & Inter-Institute Endocrinology Training Program, Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD), National Institutes of Health (NIH), NIH-Clinical Research Center, 10 Center Drive, Building 10, Room 1-3330, MSC1103, Bethesda, MD, 20892, USA.

The last 10 years have produced an amazing number of significant discoveries in the field of adrenal endocrinology. The development of the adrenal gland was linked to specific molecules. Cortisol-producing lesions were associated mostly with defects of the cyclic AMP (cAMP) signaling pathway, whereas aldosterone-producing lesions were found to be the result of defects in aldosterone biosynthesis or the potassium channel KCNJ5 and related molecules. Read More

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November 2018
1 Read

Molecular Profiling of Pheochromocytoma and Abdominal Paraganglioma Stratified by the PASS Algorithm Reveals Chromogranin B as Associated With Histologic Prediction of Malignant Behavior.

Am J Surg Pathol 2018 Nov 16. Epub 2018 Nov 16.

Department of Oncology-Pathology, Karolinska Institutet, Karolinska University Hospital, CCK.

Pheochromocytomas (PCCs) and abdominal paragangliomas (PGLs), collectively abbreviated PPGL, are believed to exhibit malignant potential-but only subsets of cases will display full-blown malignant properties. The Pheochromocytoma of the Adrenal Gland Scaled Score (PASS) algorithm is a proposed histologic system to detect potential for aggressive behavior, but little is known regarding the coupling to underlying molecular genetics. In this study, a total of 92 PPGLs, previously characterized for susceptibility gene status and mRNA expressional profiles, were histologically assessed using the PASS criteria. Read More

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November 2018
2 Reads

[Pheochromocytoma in multiple endocrine neoplasia 2A associated with pulmonary tuberculosis presenting as abdominal pain: a case report and literature review].

Medwave 2018 Nov 9;18(7):e7320. Epub 2018 Nov 9.

Departamento de Medicina Interna, Hospital Nacional Edgardo Rebagliati Martins, Lima, Perú.

Pheochromocytoma is a catecholamine-producing neoplasm that may occur sporadically or associated with hereditary diseases, such as multiple endocrine neoplasia. The classic symptoms are headache, sweating, and palpitations and are attributed to the sympathetic nervous system activity, usually presenting as paroxysms. On the other hand, pulmonary tuberculosis is an infectious disease considered a public health problem in many countries, whose incidence depends on risk factors such as immunosuppression. Read More

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November 2018
2 Reads

Neuroprotective influence of sitagliptin against cisplatin-induced neurotoxicity, biochemical and behavioral alterations in Wistar rats.

Mol Cell Biochem 2018 Nov 16. Epub 2018 Nov 16.

Department of Pharmacology, Mahatma Gandhi University of Medical Sciences & Technology, Jaipur, India.

Cisplatin has been extensively used as a chemotherapeutic agent since around 40 years, though its usage is limited due to severe adverse effects like neurotoxicity that might be because of oxidative stress. Hence, the present study was planned to investigate the possible protective role of sitagliptin against cisplatin-associated neurotoxic, biochemical, and behavioral alterations in male Wistar rats. Sitagliptin is a dipeptidyl peptidase-4 inhibitor that shows dual effects by improving the control on metabolism as well as decreasing the debility in cognitive function that is associated with increased insulin sensitivity and antioxidant property. Read More

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November 2018
2 Reads

Perioperative Hypertensive Urgency After Methylene Blue in a Patient With Undiagnosed Pheochromocytoma: A Case Report.

A A Pract 2018 Nov 12. Epub 2018 Nov 12.

From the Department of Anesthesiology, Yale University School of Medicine, New Haven, Connecticut.

We report the perioperative course of a 75-year-old woman undergoing robotic-assisted laparoscopic hysterectomy and tumor debulking. The patient developed severe, persistent hypertension after intraoperative methylene blue administration requiring a Surgical Intensive Care Unit admission with further investigative evaluation revealing a previously undiagnosed pheochromocytoma. Our discussion focuses on the differential diagnoses for her perioperative hypertension. Read More

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November 2018
1 Read

Transperitoneal versus retroperitoneal laparoscopic adrenalectomy for large pheochromocytoma: Comparative outcomes.

Int J Urol 2018 Nov 14. Epub 2018 Nov 14.

Department of Urology, Graduate School of Medicine, Yamaguchi University, Ube, Yamaguchi, Japan.

Objectives: To evaluate operative and oncological outcomes of laparoscopic adrenalectomy through a transperitoneal approach and retroperitoneal approach for large (>5 cm in diameter) pheochromocytomas.

Methods: We retrospectively compared the results of a transperitoneal approach with those of a retroperitoneal approach in 22 patients (mean age 57.5 years, range 38-76 years) with unilateral large pheochromocytomas (12 right, 10 left). Read More

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November 2018
1 Read

Whole-body magnetic resonance imaging (WB-MRI) in oncology: recommendations and key uses.

Radiol Med 2018 Nov 14. Epub 2018 Nov 14.

Department of Radiology, IEO, European Institute of Oncology IRCCS, Milan, Italy.

The past decade has witnessed a growing role and increasing use of whole-body magnetic resonance imaging (WB-MRI). Driving these successes are developments in both hardware and software that have reduced overall examination times and significantly improved MR imaging quality. In addition, radiologists and clinicians have continued to find promising new applications of this innovative imaging technique that brings together morphologic and functional characterization of tissues. Read More

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November 2018
1 Read

Vlasoulamine A, a Neuroprotective [3.2.2]Cyclazine Sesquiterpene Lactone Dimer from the Roots of Vladimiria souliei.

Org Lett 2018 Nov 13. Epub 2018 Nov 13.

School of Pharmacy , Second Military Medical University , Shanghai 200433 , P.R. China.

Vlasoulamine A (1), an unprecedented sesquiterpene lactone dimer featuring a fully hydrogenated pyrrolo[2,1,5- cd]indolizine core, and vlasoulones A and B (2 and 3), a pair of epimeric dimers formed from a proposed Diels-Alder [4 + 2] cycloaddition between a germacrane sesquiterpene lactone and a eudesmane sesquiterpene, were isolated from the roots of Vladimiria souliei. Their structures and absolute configurations were established by NMR, MS, and single-crystal X-ray spectroscopic analysis. Moreover, 1 exhibited neuroprotective activity when evaluated for glutamate-induced cytotoxicity, nuclear Hoechst 33258 staining, and measuring intracellular reactive oxygen species levels, using a rat pheochromocytoma PC12 cell-based model system. Read More

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November 2018
1 Read

The Role of Immunohistochemistry and Molecular Analysis of Succinate Dehydrogenase in the Diagnosis of Endocrine and Non-Endocrine Tumors and Related Syndromes.

Endocr Pathol 2018 Nov 12. Epub 2018 Nov 12.

Department of Pathology, University Medical Center/Princess Maxima Center for Pediatric Oncology, Utrecht, The Netherlands.

Succinate dehydrogenase (SDH) is an enzyme complex, composed of four protein subunits, that plays a role in both the citric acid cycle and the electron transport chain. The genes for SDHA, SDHB, SDHC, and SDHD are located in the nuclear DNA, and mutations in these genes have initially been described in paragangliomas (PGL) and pheochromocytomas (PCC), which are relatively rare tumors derived from the autonomic nervous system and the adrenal medulla, respectively. Patients with SDH mutations, that are almost exclusively in the germline, are frequently affected by multiple PGL and/or PCC. Read More

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November 2018
6 Reads

NAP protects against Tau hyperphosphorylation through GSK3.

Curr Pharm Des 2018 Nov 11. Epub 2018 Nov 11.

The Lily and Avraham Gildor Chair for the Investigation of Growth Factors; The Elton Laboratory for Neuroendocrinology; Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine, Sagol School of Neuroscience and Adams Super Center for Brain Studies, Tel Aviv University, Tel Aviv 69978. Israel.

Background: The most common form of dementia is Alzheimer's disease (AD), which is characterized, in part, by the accumulation of neurofibrillary tangles (NFT), followed by synaptic and neuronal loss. NFTs are mainly composed of aggregated hyperphosphorylated Tau. It has been demonstrated that pathological concentrations of zinc induce 1] activation of a major Tau kinase - the glycogen synthase kinase-3β (GSK-3β), and 2] promote Tau aggregation and toxicity. Read More

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November 2018
5 Reads

Secondary Arterial Hypertension: From Routine Clinical Practice to Evidence in Patients with Adrenal Tumor.

High Blood Press Cardiovasc Prev 2018 Dec 10;25(4):345-354. Epub 2018 Nov 10.

Endocrinology Unit, Department of Medicine DIMED, University-Hospital of Padova, Via Ospedale Civile, 105, 35128, Padova, Italy.

Prevalence of arterial hypertension is up to 30-40% in epidemiological studies, it increases with aging and affects the cardiovascular risk. Essential form of hypertension is the most frequent; however, 5-10% of patients are affected by a specific and potentially reversible cause of increased blood pressure levels, called secondary hypertension. In general, all patients with young onset-age (< 40-50 years) or resistant hypertension should be screened for secondary forms. Read More

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December 2018
10 Reads

Metabolic subtyping of pheochromocytoma and paraganglioma by F-FDG pharmacokinetics using dynamic PET/CT scanning.

J Nucl Med 2018 Nov 9. Epub 2018 Nov 9.

Radboud University Medical Center, Netherlands.

Static single timeframe F-FDG PET/CT is useful for the localization and functional characterization of pheochromocytoma and paraganglioma (PPGL). F-FDG-uptake varies between PPGLs with different genotypes and highest standardized uptake values (SUVs) are observed in case of succinate dehydrogenase (SDH) mutations, possibly related to enhanced aerobic glycolysis in tumor cells. The exact determinants of F-FDG accumulation in PPGL are unknown. Read More

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November 2018
4 Reads

Regarding: A clinical prediction model to estimate the metastatic potential of pheochromocytoma/paraganglioma: ASES score.

Surgery 2018 Nov 5. Epub 2018 Nov 5.

Department of Endocrine Surgery, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India.

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November 2018
3 Reads

Metabolic Syndrome as a Predictor of Adrenal Functional Status: A Discriminant Multivariate Analysis Versus Logistic Regression Analysis.

Horm Metab Res 2018 Nov 7. Epub 2018 Nov 7.

Department of Endocrinology, Metabolism and Diabetes Mellitus, Nikea-Piraeus General Hospital "Agios Panteleimon", Athens, Greece.

Patients harboring adrenal tumors are characterized by higher prevalence of metabolic syndrome (MetS) components and a higher incidence of cardiovascular complications, especially in cases of subclinical or overt hormonal hypersecretion. Early detection and referral of those patients in tertiary centers could prevent unfavorable outcomes. In this cross-sectional, retrospective study, we evaluated 111 consecutive patients with adrenal incidentalomas and 14 patients with known hypersecretory adrenal lesions (autonomous cortisol secretion, primary aldosteronism, and pheochromocytoma), who were investigated in our clinic. Read More

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November 2018
1 Read

Simultaneous Pheochromocytoma, Paraganglioma, and Papillary Thyroid Carcinoma without Known Mutation.

Case Rep Endocrinol 2018 14;2018:6358485. Epub 2018 Oct 14.

Einstein Medical Center, 5501 Old York Rd., Philadelphia, PA 19141, USA.

Background: Pheochromocytoma/paraganglioma is a rare tumor from neuroendocrine cells. 1/3 of cases have germline mutations. Papillary thyroid carcinoma (PTC) is a common neoplasm from follicular cells of the thyroid. Read More

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October 2018
5 Reads

Da-Bu-Yin-Wan Improves the Ameliorative Effect of DJ-1 on Mitochondrial Dysfunction Through Augmenting the Akt Phosphorylation in a Cellular Model of Parkinson's Disease.

Front Pharmacol 2018 18;9:1206. Epub 2018 Oct 18.

State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Neuroscience Center, Institute of Materia Medica, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China.

Da-Bu-Yin-Wan (DBYW) is recorded originally in China over six centuries ago, and it is used to treat Parkinson's disease (PD) clinically in recent decades. DJ-1 is a homodimeric protein linked to early-onset PD, and found in the mitochondria. In addition, DJ-1 could protect the cells by regulating gene transcription and modulating the Akt signal pathways. Read More

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October 2018
4 Reads

First Reported Case of Endoscopic Ultrasound-Guided Core Biopsy Yielding Diagnosis of Primary Adrenal Leiomyosarcoma.

Case Rep Gastrointest Med 2018 3;2018:8196051. Epub 2018 Oct 3.

Division of Gastroenterology and Hepatology, University of Florida and Malcom Randall VA Medical Center, Gainesville, FL, USA.

Primary adrenal leiomyosarcoma (PAL) is an extremely rare mesenchymal tumor with only a few isolated case reports in the medical literature. Endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) or endoscopic ultrasound-guided core biopsy (EUS-CB) is a safe, effective modality for sampling lesions in the gastrointestinal tract and adjacent organs, including the adrenal glands. We describe the case of a 50-year-old male presenting with abdominal pain and unintentional weight loss over the course of one year. Read More

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October 2018
6 Reads

Hemodynamic instability during percutaneous ablation of extra-adrenal metastases of pheochromocytoma and paragangliomas: a case series.

BMC Anesthesiol 2018 Nov 6;18(1):158. Epub 2018 Nov 6.

Department of Anesthesiology and Perioperative Medicine, Mayo Clinic College of Medicine and Science, 200 First Street SW, Rochester, MN, 55905, USA.

Background: Surgical manipulation of pheochromocytomas and paragangliomas (PPGLs) may induce large hemodynamic oscillations due to catecholamine release. Little is known regarding hemodynamic instability during percutaneous ablation of PPGLs. We examined intraprocedural hemodynamic variability and postoperative complications related to percutaneous ablation of extra-adrenal metastases of PPGL. Read More

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November 2018
5 Reads

[Risk factors of postoperative complications after laparoscopic surgery for pheochromocytoma].

Zhonghua Yi Xue Za Zhi 2018 Oct;98(37):2999-3004

Department of Critical Care Medicine, Peking University First Hospital, Beijing 100034, China.

To investigate the effects of intraoperative hemodynamic instability on postoperative complications of laparoscopic surgery for pheochromocytoma. It was a retrospective cohort study. According to inclusion/exclusion criteria, adult patients underwent laparoscopic surgery for pheochromocytoma from January 2005 to December 2017 in Peking University First Hospital were enrolled in this study. Read More

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October 2018
1 Read

Performance of plasma free metanephrines in diagnosis of pheochromocytomas and paragangliomas in the population of Asturias.

Endocrinol Diabetes Nutr 2018 Nov 1. Epub 2018 Nov 1.

Laboratorio de Medicina, Servicio de Bioquímica Clínica, Hospital Universitario Central de Asturias, Oviedo, España; Departamento de Bioquímica y Biología Molecular, Universidad de Oviedo, Oviedo, España.

Introduction: Pheochromocytoma and paraganglioma are uncommon tumors whose best known symptoms include high blood pressure, palpitations, headache, and sweating. Clinical identification is not easy, however, and requires biochemical tests that allow for early diagnosis, including measurement of metanephrines levels. The aim of this study was to assess the diagnostic performance of plasma free metanephrines (PMETs) and to verify the transferability of the reference values used. Read More

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November 2018
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Hypoxia Signaling and Circadian Disruption in and by Pheochromocytoma.

Front Endocrinol (Lausanne) 2018 16;9:612. Epub 2018 Oct 16.

Department of Medicine and Health Science, Linköping University, Linköping, Sweden.

Disruption of the daily (i.e., circadian) rhythms of cell metabolism, proliferation and blood perfusion is a hallmark of many cancer types, perhaps most clearly exemplified by the rare but detrimental pheochromocytomas. Read More

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October 2018
3 Reads

CT characteristics of pheochromocytoma - Relevance for the evaluation of adrenal incidentaloma.

J Clin Endocrinol Metab 2018 Oct 31. Epub 2018 Oct 31.

Department of Internal Medicine, Division of Endocrinology, Radboud University Medical Center, Nijmegen, The Netherlands.

Background: Up to 7% of all adrenal incidentalomas (AIs) are pheochromocytomas (PCCs). In the evaluation of AI, it is generally recommended to exclude PCC by measurement plasma free or 24h urinary fractionated metanephrines. However, recent studies suggest to abstain from biochemical exclusion of PCC in cases of lesions with computed tomography (CT) characteristics of an adrenocortical adenoma (ACA). Read More

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October 2018
9 Reads

Pheochromocytoma with Brain Metastasis: A Extremely Rare Case in Worldwide.

Brain Tumor Res Treat 2018 Oct;6(2):101-104

Department of Neurosurgery, Brain Tumor Center, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.

Pheochromocytoma (PCC) is a neuroendocrine tumor that mainly arises from the medulla of the adrenal gland. Some PCCs become malignant and metastasize to other organs. For example, it typically involves skeletal system, liver, lung, and regional lymph nodes. Read More

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October 2018
5 Reads