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    Malignant pheochromocytoma-paraganglioma: pathogenesis, TNM staging, and current clinical trials.
    Curr Opin Endocrinol Diabetes Obes 2017 Feb 23. Epub 2017 Feb 23.
    aDepartment of Endocrinology, Hospital Universitario San Vicente Fundacion-Universidad de Antioquia, Medellín, Colombia bDepartment of Endocrine Neoplasia and Hormonal Disorders, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
    Purpose Of Review: Pheochromocytomas and paragangliomas (PPGs) are rare neuroendocrine tumors. Over the last 15 years, substantial progress has been made toward understanding the clinical aspects and molecular origins of this disease. Nevertheless, predicting and managing malignancy remains the biggest challenge in clinical practice. Read More

    Implications of SDHB genetic testing in patients with sporadic pheochromocytoma.
    Langenbecks Arch Surg 2017 Feb 22. Epub 2017 Feb 22.
    Department of Nuclear Medicine, La Timone University Hospital, APHM, CERIMED, Aix Marseille Univ, Marseille, France.
    Purpose: Succinate dehydrogenase B (SDHB) associated pheochromocytomas (PHEOs) are associated with a higher risk of tumor aggressiveness and malignancy. The aim of the present study was to evaluate (1) the frequency of germline SDHB mutations in apparently sporadic patients with PHEO who undergo preoperative genetic testing and (2) the ability to predict pathogenic mutations.

    Methods: From 2012 to 2016, 82 patients underwent a PHEO surgical resection. Read More

    Surgical treatment of left ventricular wall rupture, regarded as a consequence of Takotsubo cardiomyopathy.
    SAGE Open Med Case Rep 2017 18;5:2050313X16689210. Epub 2017 Jan 18.
    Scientific Research Institute of Heart Surgery and Organ Transplantation, Bishkek, Kyrgyzstan.
    Objective: We present the case of possible reverse type of TCM in a female patient presented with progressive left ventricular dysfunction and its rupture in pericardium.

    Methods: The detailed history, physical examination, laboratory tests, electrocardiography, serial echocardiography, coronary angiography with left ventriculography were performed to diagnose possible Takotsubo cardiomyopathy in 63-year old woman admitted to our center with complaints of dyspnea, lightheadedness, weakness and signs of hypotension and history of inferior myocardial infarction, acute left ventricular aneurysm, and effusive pericarditis and pleuritis, developed after emotional stress 5 months ago.

    Results: Clinical evaluation revealed unremarkable laboratory tests, normal troponin values, signs of old inferior myocardial infarction on electrocardiogram, and left ventricular (LV) dilatation and dysfunction, akinesia of LV infero-lateral wall with thinning and its rupture and blood shunting in pericardium. Read More

    Update on CT and MRI of Adrenal Nodules.
    AJR Am J Roentgenol 2017 Feb 22:1-12. Epub 2017 Feb 22.
    2 Department of Radiology, Hospital of the University of Pennsylvania, University of Pennsylvania, Philadelphia, PA.
    Objective: The objective of this article is to review the current role of CT and MRI for the characterization of adrenal nodules.

    Conclusion: Unenhanced CT and chemical-shift MRI have high specificity for lipid-rich adenomas. Dual-energy CT provides comparable to slightly lower sensitivity for the diagnosis of lipid-rich adenomas but may improve characterization of lipid-poor adenomas. Read More

    Changes in Body Mass Index in Pheochromocytoma Patients Following Adrenalectomy.
    Horm Metab Res 2017 Feb 21. Epub 2017 Feb 21.
    Medizinische Klinik und Poliklinik IV, Endocrine Research Unit, Klinikum der Universität München, LMU, Ziemssenstr. 1, Munich, Germany.
    Catecholamine excess from pheochromocytoma results in cardiovascular symptoms such as arterial hypertension and tachycardia and induces metabolic alterations including glucose intolerance and increase in resting metabolic rate. The objective of our study was to investigate the effect of surgical cure of pheochromocytoma on body-mass-index and the correlation of body-mass-index changes to preoperative endocrine parameters. Pheochromocytoma patients from the Munich ENSAT Registry were matched (1:2) for age and gender to patients from the German Conn's Registry, who had undergone surgery for aldosterone-producing-adenomas. Read More

    Study of awareness of adrenal disorders among interns and postgraduate students of Hamidia Hospital, Bhopal.
    Indian J Endocrinol Metab 2017 Jan-Feb;21(1):251-254
    Department of Medicine, Gandhi Medical College, Bhopal, Madhya Pradesh, India.
    Introduction: Adrenal disorders could be a life-threatening emergency, hence requires immediate therapeutic management. For this awareness regarding its diagnosis, management, and treatment is prime important.

    Aims And Objective: To study the awareness of adrenal disorders among interns and postgraduates students of Hamidia Hospital, Bhopal. Read More

    Bowel perforation complicating an ACTH-secreting phaeochromocytoma.
    Endocrinol Diabetes Metab Case Rep 2016 24;2016. Epub 2016 Aug 24.
    Austin Health, Heidelberg, Victoria, Australia; University of Melbourne, Parkville, Victoria, Australia.
    ACTH-secreting phaeochromocytoma (ASP) is a rare cause of ACTH-dependent Cushing's syndrome (CS). We report the case of a 63-year-old female presenting with CS secondary to an ASP complicated by bowel perforation. This case report highlights ASP as an uncommon but important cause of ectopic ACTH secretion (EAS). Read More

    Mixed corticomedullary adrenal carcinoma - case report: Comparison in features, treatment and prognosis with the other two reported cases.
    Int J Surg Case Rep 2017 Jan 31;31:254-261. Epub 2017 Jan 31.
    Alberoni Hospital, Damascus University Faculty of Medicine, P.O. Box: 60527, Damascus, Syria. Electronic address:
    Introduction: Adrenal corticomedullary adenoma was reviewed in many cases in PubMed Library, While the coincidence corticomedullary adrenal carcinoma in the same gland was just described in two cases in the medical literature. Our case is the third to be reported and was treated with surgery and adjuvant chemotherapy and followed for two years.

    Presentation Of Case: A 50-year-old man suffered from a mass effect in the left abdominal side. Read More

    Atypical presentation of pheochromocytoma: Central nervous system pseudovasculitis.
    Indian J Urol 2017 Jan-Mar;33(1):82-84
    Department of Urology and Kidney Transplant, Medanta - The Medicity, Gurgaon, Haryana, India.
    Pheochromocytoma has atypical presentation in 9%-10% of patients. Atypical presentations include myocardial infarction, renal failure, and rarely cerebrovascular events. Various etiologies for central nervous system (CNS) involvement in pheochromocytoma have been described in the literature. Read More

    Current perioperative management of pheochromocytomas.
    Indian J Urol 2017 Jan-Mar;33(1):19-25
    Department of Anaesthesiology, Pain Medicine and Critical Care, All India Institute of Medical Sciences, New Delhi, India.
    Neuroendocrine tumors which have the potential to secrete catecholamines are either associated with sympathetic adrenal (pheochromocytoma) or nonadrenal (paraganglioma) tissue. Surgical removal of these tumors is always indicated to cure and prevent cardiovascular and other organ system complications associated with catecholamine excess. Some of these tumors have malignant potential as well. Read More

    [Clinical features and mutations of RET proto-oncogene in a pedigree affected with type 2A multiple endocrine neoplasia].
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2017 Feb;34(1):106-109
    Department of Endocrinology and Metabolism, Huai'an Second People's Hospital, Huai'an, Jiangsu 223002, China.
    Objective: To investigate the clinical features and mutations of RET proto-oncogene in a pedigree affected with multiple endocrine neoplasia type 2A (MEN2A).

    Methods: Clinical data of the family members was collected. Genomic DNA from peripheral blood leukocytes were extracted and subjected to PCR amplification. Read More

    Recommendations For The Management Of Adrenal Incidentalomas: What is pertinent for Radiologists?
    Br J Radiol 2017 Feb 9:20160627. Epub 2017 Feb 9.
    1 Department of Imaging, St Bartholomew's Hospital, Barts Health NHS Trust, London UK EC1A 7BE.
    Adrenal incidentalomas are unsuspected, asymptomatic adrenal masses detected on imaging. Most are non-functioning benign adrenocortical adenomas, but can represent other benign lesions or lesions requiring therapeutic intervention including adrenocortical carcinoma, pheochromocytoma, hormone-producing adenoma or metastasis. This review summarises and highlights radiological recommendations within the recently issued guidelines for the management of adrenal incidentalomas from European Society of Endocrinology Clinical Practice in collaboration with European Network for Study of Adrenal Tumours. Read More

    Potential Pitfalls of SDH Immunohistochemical Detection in Paragangliomas and Phaeochromocytomas Harbouring Germline SDHx Gene Mutation.
    Anticancer Res 2017 02;37(2):805-812
    Division of Pathological Anatomy, University of Florence, Florence, Italy
    Background/aim: Germline mutations in any of the succinate dehydrogenase (SDH) genes result in destabilization of the SDH protein complex and loss of SDHB expression at immunohistochemistry. SDHA is lost together with SDHB in SDHA-mutated tumours, but its expression is retained in tumours with other SDH mutations. We investigated whether SDHA/SDHB immunohistochemistry is able to identify SDH-related tumours in a retrospective case series of phaeochromocytomas (PCCs) and paragangliomas (PGLs). Read More

    Peptide Receptor Radionuclide Treatment and (131)I-MIBG in the management of patients with metastatic/progressive phaeochromocytomas and paragangliomas.
    J Surg Oncol 2017 Feb 6. Epub 2017 Feb 6.
    ENETS Centre of Excellence Neuroendocrine Tumour Unit, Royal Free London NHS Foundation Trust, London, UK.
    Background And Objectives: Radionuclide therapy has been used to treat patients with progressive/metastatic paragangliomas (PGLs) and phaeochromocytomas (PCCs). The aim of the present study is to retrospectively compare the therapeutic outcomes of these modalities in patients with progressive/metastatic PCCs and PGLs.

    Methods: Patients with progressive/metastatic PGLs and PCCs that were subjected to radionuclide treatment in our department were retrieved from our department's database for the period 1998-2013. Read More

    Comprehensive Molecular Characterization of Pheochromocytoma and Paraganglioma.
    Cancer Cell 2017 Feb 2;31(2):181-193. Epub 2017 Feb 2.
    Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address:
    We report a comprehensive molecular characterization of pheochromocytomas and paragangliomas (PCCs/PGLs), a rare tumor type. Multi-platform integration revealed that PCCs/PGLs are driven by diverse alterations affecting multiple genes and pathways. Pathogenic germline mutations occurred in eight PCC/PGL susceptibility genes. Read More

    Biomarker, Molecular, and Technologic Advances in Urologic Pathology, Oncology, and Imaging.
    Arch Pathol Lab Med 2017 Feb 3. Epub 2017 Feb 3.
    From the Departments of Pathology (Drs Ellis, Harik, Cohen, and Osunkoya), Urology (Dr Osunkoya), and the Winship Cancer Institute (Dr Osunkoya), Emory University School of Medicine, Atlanta, Georgia; and the Department of Pathology, Veterans Affairs Medical Center, Atlanta, Georgia (Dr Osunkoya).
    Urologic pathology is evolving rapidly. Emerging trends include the expanded diagnostic utility of biomarkers and molecular testing, as well as adapting to the plethora of technical advances occurring in genitourinary oncology, surgical practice, and imaging. We illustrate those trends by highlighting our approach to the diagnostic workup of a few selected disease entities that pathologists may encounter, including newly recognized subtypes of renal cell carcinoma, pheochromocytoma, and prostate cancer, some of which harbor a distinctive chromosomal translocation, gene loss, or mutation. Read More

    Adrenomedullin - new perspectives of a potent peptide hormone.
    J Pept Sci 2017 Feb 2. Epub 2017 Feb 2.
    Faculty of Biosciences, Pharmacy and Psychology, Institute of Biochemistry, Leipzig University, Brüderstraße 34, 04103, Leipzig, Germany.
    Adrenomedullin (ADM) is a 52-amino acid multifunctional peptide, which belongs to the calcitonin gene-related peptide (CGRP) superfamily of vasoactive peptide hormones. ADM exhibits a significant vasodilatory potential and plays a key role in various regulatory mechanisms, predominantly in the cardiovascular and lymphatic system. It exerts its effects by activation of the calcitonin receptor-like receptor associated with one of the receptor activity-modifying proteins 2 or 3. Read More

    Pheochromocytoma: A Cause of Anemia.
    Urol Case Rep 2017 Feb 28;11:53-54. Epub 2017 Jan 28.
    QEQM Hospital, East Kent Hospitals University NHS Foundation Trust, Margate, UK.
    Patients with a Pheochromocytoma usually present with intractable hypertension, postural hypotension, headaches and palpitations, with intractable hypertension being the predominant symptom. When the tumor is located in the urinary bladder, symptoms may be induced by micturition. Herein, we report a young patient with a urinary bladder Pheochromocytoma without hypertension or symptoms induced by micturition. Read More

    Lesson of the month 1: Subacute thyroiditis: a rare cause of fever of unknown origin.
    Clin Med (Lond) 2017 Feb;17(1):86-87
    Sultan Qaboos University Hospital, Al Khod, Muscat, Oman.
    Fever of unknown origin (FUO) is sometimes a diagnostic dilemma for clinicians. Endocrine causes reported in the literature include subacute thyroiditis, thyrotoxicosis, adrenal insufficiency and pheochromocytoma. Among these, subacute thyroiditis is often overlooked as it can occasionally lack typical symptoms. Read More

    [Von Hippel-Lindau syndrome - two sides of the same coin].
    Vnitr Lek 2016 ;62(12):1004-1008
    Von Hippel-Lindau syndrome (VHL) is a rare genetic disease. Its incidence is 1 : 36,000, there is the familial occurrence in 80 % of cases , the remaining cases are de novo mutations. The disease is caused by the highly penetrant mutations in the VHL gene (3p25. Read More

    Multiple Endocrine Neoplasia Type 2B Unmasked by 18F-FDG PET/CT and 131I-MIBG SPECT/CT.
    Clin Nucl Med 2017 Jan 27. Epub 2017 Jan 27.
    From the Department of Nuclear Medicine, and Hubei Province Key Laboratory of Molecular Imaging, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China.
    F-FDG PET/CT was performed to detect an occult malignancy in a 26-year-old woman with complicated medical history which included paroxysmal hypertension and significantly elevated tumor marker. The images revealed lesions in the thyroid, lymph nodes, and bilateral adrenal glands. Further I-MIBG SPECT/CT revealed intense activity in the lesion in the left adrenal gland, which was consistent with pheochromocytoma. Read More

    Rifampicin pre-treatment inhibits the toxicity of rotenone-induced PC12 cells by enhancing sumoylation modification of α-synuclein.
    Biochem Biophys Res Commun 2017 Jan 26. Epub 2017 Jan 26.
    Department of Neurology, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, 107 Yanjiang West Road, Guangzhou 510080, China; Guangdong Province Key Laboratory of Brain Function and Disease, Zhongshan School of Medicine, Sun Yat-sen University, 74 Zhongshan 2nd Road, Guangzhou 510080, China. Electronic address:
    Our previous research revealed that rifampicin could protect PC12 (pheochromocytoma 12) cells from rotenone-induced cytotoxicity by reversing the aggregation of α-synuclein. Furthermore, increasing evidence indicated that the misfolded α-synuclein with SUMOylation, an important protein posttranslational modification, was easier to solubilize and was less toxic. Here, we investigated whether rifampicin could stabilize α-synuclein and prevent rotenone-induced PC12 cells from undergoing apoptosis by enhancing SUMOylation of α-synuclein. Read More

    Management of Adrenal Masses.
    Indian J Surg Oncol 2017 Mar 17;8(1):67-73. Epub 2016 Dec 17.
    Department of Urology, Amrita Institute of Medical Sciences, Amrita Vishwa Vidyapeetham, Amrita lane elmakkara, Kochi, Kerala 682041 India.
    An adrenal mass can be either symptomatic or asymptomatic in the form of adrenal incidentalomas (AIs) in up to 8 % in autopsy and 4 % in imaging series. Once a diagnosis of adrenal mass is made, we need to differentiate whether it is functioning or nonfunctioning, benign, or malignant. In this article, we provide a literature review of the diagnostic workup including biochemical evaluation and imaging characteristics of the different pathologies. Read More

    Practical Approach to Adrenal Imaging.
    Radiol Clin North Am 2017 Mar 12;55(2):279-301. Epub 2016 Dec 12.
    Department of Diagnostic Radiology, The University of Texas MD Anderson Cancer Center, 1400 Pressler Street Unit 1473, Houston, TX 77030, USA.
    Various pathologies can affect the adrenal gland. Noninvasive cross-sectional imaging is used for evaluating adrenal masses. Accurate diagnosis of adrenal lesions is critical, especially in cancer patients; the presence of adrenal metastasis changes prognosis and treatment. Read More

    Successful treatment of metastatic pheochromocytoma in the spine with cement augmentation.
    Medicine (Baltimore) 2017 Jan;96(4):e5892
    aDepartment of Orthopaedic Surgery bDepartment of Neurosurgery, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China cDepartment of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Harvard University, Boston, MA.
    Metastatic pheochromocytoma in the spine is rare, and there is no standard curative management. Treatment via open surgery is often risky in the perioperative period, while osteoplasty by cement augmentation is a less invasive option.We describe 2 patients with recurrence of pheochromocytoma involving the spine and the pelvis who were successfully treated with osteoplasty by cement augmentation. Read More

    Pheochromocytomas and paragangliomas in humans and dogs.
    Vet Comp Oncol 2017 Jan 25. Epub 2017 Jan 25.
    Department of Pathology, Erasmus Medical Center Cancer Institute, University Medical Center Rotterdam, Rotterdam, The Netherlands.
    Pheochromocytomas (PCCs) and paragangliomas (PGLs) are described in several species. In humans and dogs they have many similarities: the excessive catecholamine release in hormonally active PCC causes similar clinical signs, the frequency of metastasis is similar, and they are histopathologically almost identical. Surgery is curative when PCC and PGL have not metastasized, while only palliative treatment is possible for patients with metastatic disease. Read More

    A Somatic HIF2α Mutation-Induced Multiple and Recurrent Pheochromocytoma/Paraganglioma with Polycythemia: Clinical Study with Literature Review.
    Endocr Pathol 2017 Mar;28(1):75-82
    Department of Urology, Institute of Surgery Research, Daping Hospital, Third Military Medical University, No. 10 Changjiangzhilu, Yuzhong District, Chongqing, 400042, People's Republic of China.
    A syndrome known as pheochromocytomas (PCC)/paragangliomas (PGL) and polycythemia resulted from gain-of-function mutation of hypoxia-inducible factor 2α (HIF2α) has been reported recently. However, clinical features of this syndrome vary from patient to patient. In our study, we described the clinical features of the patient within 15-year follow-up with a literature review. Read More

    Controlling Tumor Progression with Cyclophosphamide, Vincristine, and Dacarbazine Treatment Improves Survival in Patients with Metastatic and Unresectable Malignant Pheochromocytomas/Paragangliomas.
    Horm Cancer 2017 Jan 20. Epub 2017 Jan 20.
    Division of Endocrinology, Metabolism and Hypertension, Clinical Research Institute, National Hospital Organization Kyoto Medical Center, 1-1, Mukaihatacho, Fukakusa, Fushimi-ku, Kyoto, 612-8555, Japan.
    Evidence has not been established to support that combination chemotherapy with cyclophosphamide, vincristine, and dacarbazine (CVD) improves survival in patients with malignant pheochromocytoma and paraganglioma (M-PPGL). To investigate the efficacy of CVD for this disease, we retrospectively analyzed data of 23 patients with metastatic and unresectable M-PPGL (mean age, 41.7 ± 15. Read More

    An unusual case of a Pheochromocytoma mimicking both Acute Coronary Syndrome and Central Nervous System Infection. Case report and literature review.
    Hellenic J Cardiol 2017 Jan 17. Epub 2017 Jan 17.
    Cardiology Department, Larnaca General Hospital, Larnaca, Cyprus.
    Pheochromocytoma has been called 'the great mimic', capable of presenting itself as many other medical conditions. We present a 58-year-old woman admitted with recurrent episodes of nausea and vomiting and high blood pressure. Elevated cardiac biomarkers and diffuse ST-T abnormalities on electrocardiography suggested myocardial injury. Read More

    Perioperative management of a large, late presenting phaeochromocytoma.
    BMJ Case Rep 2017 Jan 18;2017. Epub 2017 Jan 18.
    North Shore Hospital, Auckland, New Zealand.
    A 77-year-old man presenting to the emergency department with an acute coronary syndrome was later found to have a phaeochromocytoma. The lateness of this presentation was likely due to the protective α blocking effects of long-term terazosin therapy for his prostatism. α blockers such as terazosin are a well-recognised medical therapy in the perioperative optimisation of phaeochromocytoma because they treat the adrenergic effects of catecholamine release from the tumour such as hypertension. Read More

    Perioperative α-receptor blockade in phaeochromocytoma surgery: an observational case series.
    Br J Anaesth 2017 Feb;118(2):182-189
    Department of Surgery and Center of Minimal Invasive Surgery.
    Background: Mortality associated with surgery for phaeochromocytoma has dramatically decreased over the last decades. Many factors contributed to the dramatic decline of the mortality rate, and the influence of an α-receptor blockade is unclear and has never been tested in a randomized trial. We evaluated intraoperative haemodynamic conditions and the incidence of complications in patients with and without α-receptor blockade undergoing surgery for catecholamine producing tumours. Read More

    Loss of maternal chromosome 11 is a signature event in SDHAF2, SDHD, and VHL-related paragangliomas, but less significant in SDHB-related paragangliomas.
    Oncotarget 2017 Jan 14. Epub 2017 Jan 14.
    Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.
    Germline mutations in the succinate dehydrogenase (SDHA, SDHB, SDHC, SDHD, SDHAF2) or Von Hippel-Lindau (VHL) genes cause hereditary paraganglioma/pheochromocytoma. While SDHB (1p36) and VHL (3p25) are associated with autosomal dominant disease, SDHD (11q23) and SDHAF2 (11q13) show a remarkable parent-of-origin effect whereby tumor formation is almost completely dependent on paternal transmission of the mutant allele. Loss of the entire maternal copy of chromosome 11 occurs frequently in SDHD-linked tumors, and has been suggested to be the basis for this typical inheritance pattern. Read More

    Different RET gene mutation-induced multiple endocrine neoplasia type 2A in 3 Chinese families.
    Medicine (Baltimore) 2017 Jan;96(3):e5967
    aDepartment of Urology, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, PR China bDepartment of Bio-Medical Sciences, Philadelphia College of Osteopathic Medicine, Philadelphia, PA.
    Backgroud: Multiple endocrine neoplasia type 2A (MEN2A) is a condition with inherited autosomal dominant mutations in RET (rearranged during transfection) gene that predisposes the carrier to extremely high risk of medullary thyroid cancer (MTC) and other MEN2A-associated tumors such as parathyroid cancer and/or pheochromocytoma. Little is reported about MEN2A syndrome in the Chinese population.

    Methods: All members of the 3 families along with specific probands of MEN2A were analyzed for their clinical, laboratory, and genetic characteristics. Read More

    High performance magneto-fluorescent nanoparticles assembled from terbium and gadolinium 1,3-diketones.
    Sci Rep 2017 Jan 16;7:40486. Epub 2017 Jan 16.
    Division of Materials Science, Department of Engineering Sciences and Mathematics, Luleå University of Technology, SE-97187 Luleå, Sweden.
    Polyelectrolyte-coated nanoparticles consisting of terbium and gadolinium complexes with calix[4]arene tetra-diketone ligand were first synthesized. The antenna effect of the ligand on Tb(III) green luminescence and the presence of water molecules in the coordination sphere of Gd(III) bring strong luminescent and magnetic performance to the core-shell nanoparticles. The size and the core-shell morphology of the colloids were studied using transmission electron microscopy and dynamic light scattering. Read More

    Right Atrial Paraganglioma: An Extremely Rare Primary Cardiac Neoplasm Mimicking Myxoma.
    J Cardiovasc Ultrasound 2016 Dec 28;24(4):334-336. Epub 2016 Dec 28.
    Department of Cardiothoracic Surgery, Jaipur Heart Institute, Jaipur, India.
    In this report, we present a case of 35-year-old lady who had presented with atypical chest pain and exertional breathlessness for past six months. Transthoracic and transesophageal echocardiograms showed a well-circumscribed, echo-dense mass in the right atrium, attached to the interatrial septum at the level of atrioventricular junction and in the vicinity of coronary sinus ostium. She underwent successful resection of the cardiac mass. Read More

    Pheochromocytoma Multisystem Crisis Behaving Like Interstitial Pneumonia: An Autopsy Case.
    Intern Med 2017 15;56(2):149-152. Epub 2017 Jan 15.
    Department of Cardiology, Fuchu Hospital, Japan.
    Pheochromocytoma multisystem crisis is a rare and life-threatening disease that is associated with numerous symptoms and which is also difficult to diagnose. We herein report an autopsy case of a 61-year-old man who died due to pheochromocytoma multisystem crisis. The patient complained of vomiting and breathlessness. Read More

    Genistein protects against Aβ25-35 induced apoptosis of PC12 cells through JNK signaling and modulation of Bcl-2 family messengers.
    BMC Neurosci 2017 Jan 12;18(1):12. Epub 2017 Jan 12.
    Basic Medical College, Guangdong Pharmaceutical University, Guangzhou, 510006, Guangdong, China.
    Background: Deposition of aggregated amyloid beta (Aβ) protein is hallmark of Alzheimer's disease, leading to dysfunction and apoptosis of neurons. The isoflavone phytoestrogen compound genistein (Gen) exerts a significant protective effect against Aβ25-35 induced neurotoxicity and mitochondrial damage in rat pheochromocytoma (PC12) cells. However, the mechanisms underlying Gen's rescue remain elusive. Read More

    Adrenal giant cystic pheochromocytoma treated by posterior retroperitoneoscopic adrenalectomy.
    Int J Surg Case Rep 2017 27;30:201-204. Epub 2016 Dec 27.
    Surgery C, Centro Hospitalar e Universitário de Coimbra, Hospital Geral (Covões), Portugal. Electronic address:
    Introduction: Giant cystic pheochromocytoma (>10cm) is rare with only a few cases described in the literature. Preoperative diagnosis is very difficult because clinical, biochemical and radiologic finds are usually not consistent with a pheochromocytoma. Open surgery is traditionally the gold standard. Read More

    Pheochromocytoma in Urologic Practice.
    Eur Urol Focus 2016 Feb 28;1(3):231-240. Epub 2016 Sep 28.
    Fox Chase Cancer Center, Philadelphia, Pennsylvania.
    Context: Pheochromocytoma is regularly encountered in urological practice and requires a thoughtful and careful clinical approach.

    Objective: To review clinical aspects of management of pheochromocytoma in urologic practice.

    Evidence Acquisition: A systematic review of English-language literature was performed through year 2015 using the Medline database. Read More

    Laparoscopic Unilateral Total and Contralateral Subtotal Adrenalectomy for Bilateral Adrenocorticotropic Hormone-Secreting Pheochromocytoma: Report of a Rare Case.
    J Endourol Case Rep 2016 1;2(1):232-234. Epub 2016 Dec 1.
    Department of Urology, Interdisciplinary Graduate School of Medicine, University of Yamanashi , Yamanashi, Japan .
    Background: Bilateral adrenal tumors are not common in clinical practice, but are an important source of ectopic adrenocorticotropic hormone (ACTH) secretion. Standard operative management for bilateral pheochromocytomas might dictate the removal of the involved adrenal gland and the removal of the contralateral adrenal gland. We present a case of bilateral ACTH-secreting pheochromocytoma treated with staged laparoscopic unilateral total and contralateral subtotal adrenalectomy. Read More

    Utility of the succinate: Fumarate ratio for assessing SDH dysfunction in different tumor types.
    Mol Genet Metab Rep 2017 Mar 30;10:45-49. Epub 2016 Dec 30.
    Cancer Genetics, Kolling Institute of Medical Research, Royal North Shore Hospital, Sydney, Australia; University of Sydney, Sydney, Australia.
    Objective: Mutations of genes encoding the four subunits of succinate dehydrogenase (SDH) have been associated with pheochromocytoma and paraganglioma (PPGLs), gastrointestinal stromal tumors (GISTs) and renal cell carcinomas (RCCs). These tumors have not been characterized in a way that reflects severity of SDH dysfunction. Mass spectrometric analysis now allows measurement of metabolites extracted from formalin fixed paraffin embedded (FFPE) specimens. Read More

    Comparative photodynamic therapy cytotoxicity of mannose-conjugated chlorin and talaporfin sodium in cultured human and rat cells.
    J Toxicol Sci 2017 ;42(1):111-119
    Department of Environmental Health, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences.
    Photodynamic therapy (PDT) is a Food and Drug Administration authorized method for cancer treatment, which uses photosensitizer and laser photo-irradiation to generate reactive oxygen species to induce cell death in tumors. Photosensitizers have been progressively developed, from first to third generation, with improvements in cell specificity, reduced side effects and toxicity, increased sensitivity for irradiation and reduced persistence of photosensitizer in healthy cells. These improvements have been achieved by basic comparative experiments between current and novel photosensitizers using cell lines; however, photosensitizers should be carefully evaluated because they may have cell type specificity. Read More

    Contemporary imaging of incidentally discovered adrenal masses.
    Biomed Pharmacother 2017 Mar 4;87:256-262. Epub 2017 Jan 4.
    Department of Radiology, University of Michigan Hospital, Ann Arbor, MI 48109, USA; Department of Nuclear Medicine, Department of Veterans Affairs Health System, Ann Arbor, MI 48105, USA.
    Adrenal lesions are routinely encountered incidentally in clinical practice. Although most of these lesions are benign, malignancy needs to be excluded. Therefore, the initial clinical workup is to exclude aggressive characteristics suggesting malignancy and to identify characteristics predictive of the most common benign lesion, an adrenal adenoma. Read More

    Surgical Treatment of Malignant Pheochromocytoma and Paraganglioma: Retrospective Case Series.
    Ann Surg Oncol 2017 Jan 5. Epub 2017 Jan 5.
    Department of Surgery, Mayo Clinic, Rochester, MN, USA.
    Introduction: Pheochromocytoma and paraganglioma (PPGL) are rare neoplasms; about 10% are malignant. Literature regarding possible benefit from resection is extremely limited.

    Methods: A 20 year review of all patients undergoing surgery for malignant PPGL at the Mayo Clinic Rochester Campus between 1994 and June 2014 was performed. Read More

    Adenomatoid Tumor of the Adrenal Gland in Young Woman: From Clinical and Radiological to Pathological Study.
    Rare Tumors 2016 Nov 7;8(4):6506. Epub 2016 Dec 7.
    Institute of Pathology , Medical Faculty, Skopje, Macedonia.
    Adenomatoid tumors are neoplasms of mesothelial origin, usually occurring in the male and female genital tracts. Extragenital localization sites such as adrenal glands are rare but have been reported. When found in the adrenals, they represent great clinical, radiological and pathological diagnostic challenge, with wide range of differential diagnoses to be considered. Read More

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