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    Integrated Imaging Characterization of Adrenal Adenoma: False-Positive Metaiodobenzylguanidine (MIBG) Findings of Adrenal Scintigraphy.
    Pol J Radiol 2017 4;82:422-425. Epub 2017 Aug 4.
    Department of Advanced Biomedical Sciences, University "Federico II", Naples, Italy.
    Background: Evaluation of a patient with melanoma in whom an adrenal mass was detected on CT and MR during follow-up and further characterized with PET-CT and MIBG scintigraphy.

    Case Report: In this case report, we describe a patient with melanoma in whom an adrenal mass was detected on CT and MRI during post-surgical follow-up and was further characterized with radionuclide studies consisting of PET-CT and MIBG scintigraphy. Although the results of imaging studies suggested that the mass was a pheochromocytoma, a cortical adrenal adenoma was histologically proven. Read More

    A pediatric case of pheochromocytoma without apparent hypertension associated with von Hippel-Lindau disease.
    Clin Pediatr Endocrinol 2018 13;27(2):87-93. Epub 2018 Apr 13.
    Department of Pediatrics, Keio University School of Medicine, Tokyo, Japan.
    Pheochromocytomas are catecholamine-secreting tumors. These tumors are rare in children, and they may be associated with hereditary syndromes such as von Hippel-Lindau (VHL) disease. Most pediatric patients with pheochromocytoma present with sustained hypertension, while 10% to 69% of adult patients are asymptomatic. Read More

    Pheochromocytoma (PC12) Cell Response on Mechanobactericidal Titanium Surfaces.
    Materials (Basel) 2018 Apr 14;11(4). Epub 2018 Apr 14.
    School of Science, RMIT University, Melbourne, VIC 3001, Australia.
    Titanium is a biocompatible material that is frequently used for making implantable medical devices. Nanoengineering of the surface is the common method for increasing material biocompatibility, and while the nanostructured materials are well-known to represent attractive substrata for eukaryotic cells, very little information has been documented about the interaction between mammalian cells and bactericidal nanostructured surfaces. In this study, we investigated the effect of bactericidal titanium nanostructures on PC12 cell attachment and differentiation—a cell line which has become a widely used in vitro model to study neuronal differentiation. Read More

    Partial Cystectomy of Paraganglioma of the Urinary Bladder Before Living Kidney Transplantation: Case Report.
    Transplant Proc 2018 Apr;50(3):898-901
    Department of Urology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan; Department of Advanced Transplant and Regenerative Medicine, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.
    Background: Paraganglioma (extra-adrenal pheochromocytoma) of the bladder is a very rare disease, accounting for 0.06% of all bladder tumors. Optimal management of bladder paraganglioma before kidney transplantation is unknown. Read More

    ANNALS EXPRESS: The challenge of improving the diagnostic yield from metanephrine testing in suspected phaeochromocytoma and paraganglioma.
    Ann Clin Biochem 2018 Jan 1:4563218774590. Epub 2018 Jan 1.
    Royal Perth Hospital.
    Background: Plasma free metanephrines (PFM) or urinary fractionated metanephrines (UFM) are the preferred biochemical tests for the diagnosis of phaeochromocytoma and paraganglioma (PPGL). Borderline increased results should be followed up to either exclude or confirm diagnosis.

    Methods: We extracted all PFM and UFM results reported by our laboratory over a 6-month period from the laboratory information system. Read More

    [131-I MIBG therapy of malignant pheochromocytoma and paraganglioma tumors - a single center study.]
    Endokrynol Pol 2018 Apr 12. Epub 2018 Apr 12.
    Zakład Medycyny Nuklearnej I Endokrynologii Onkologicznej, Centrum Onkologii im. M. Skłodowskiej-Curie , Instytut Onkologii w Gliwicach, ul. Wybrzeża Armii Krajowej 15, 44-101 Gliwce, Polska.
    Introduction: Pheochromocytomas and paragangliomas are rare tumors deriving from chromaffin cells of adrenal medulla or paraganglia. They are usually benign but 10-35% of them present malignant behavior. The aim of the study was to evaluate the efficacy and safety of 131-I MIBG therapy in malignant pheochromocytoma /paraganglioma patients (MPPGL). Read More

    Unusual presentation of pheochromocytoma: thirteen years of anxiety requiring psychiatric treatment.
    Endocrinol Diabetes Metab Case Rep 2018 6;2018. Epub 2018 Apr 6.
    Division of Endocrinology, Department of Medicine and Research Center (CRCHUM), Centre hospitalier de l'Université de Montréal, Montreal, Québec, Canada.
    Pheochromocytoma is a rare tumor of the adrenal gland. It often presents with the classic triad of headache, palpitations and generalized sweating. Although not described as a typical symptom of pheochromocytoma, anxiety is the fourth most common symptom reported by patients suffering of pheochromocytoma. Read More

    Paraganglioma or pheochromocytoma? A peculiar diagnosis.
    J Surg Case Rep 2018 Apr 3;2018(4):rjy060. Epub 2018 Apr 3.
    Serviço de Cirurgia II, Hospital de Egas Moniz, Centro Hospitalar de Lisboa Ocidental, 1349-019 Lisboa, Portugal.
    Paragangliomas and pheochromocytomas are rare catecholamine secreting neoplasms that arise in the extra-adrenal autonomic paraganglia and adrenal medulla, respectively. Although typically presenting with paroxysms of headaches, palpitations, diaphoresis and hypertension, a broad spectrum of clinical manifestations may occur. Diagnosis relies on biochemical studies followed by adequate imaging investigation. Read More

    Surgical Approach to the Adrenal Glands.
    Eur Endocrinol 2015 Aug 19;11(2):98-99. Epub 2015 Aug 19.
    Consultant in Endocrine Surgery, Department of Endocrine Surgery, University Hospital of Wales, Cardiff, UK.
    Any surgeon treating a patient with adrenal disease should be a member of a multi-disciplinary team involving dedicated specialists, including an endocrinologist, anaesthetist, radiologist, intensivist and geneticist. In an era of epidemic numbers of adrenal incidentalomas, great care must be taken to determine not only the endocrine diagnosis, but also the benefits (if any) of adrenal surgery. Finally, the surgeon must be competent in both minimally invasive and gross resectional surgical techniques and know when to adopt these two very different surgical approaches. Read More

    Targeting NAD+/PARP DNA repair pathway as a novel therapeutic approach to SDHB-mutated cluster I pheochromocytoma and paraganglioma.
    Clin Cancer Res 2018 Apr 10. Epub 2018 Apr 10.
    Neuro-Oncology Branch, National Cancer Institute
    Purpose: Cluster I pheochromocytomas and paragangliomas (PCPGs) tend to develop malignant transformation, tumor recurrence, and multiplicity. Transcriptomic profiling suggests that cluster I PCPGs and other related tumors exhibit distinctive changes in the tricarboxylic acid (TCA) cycle, the hypoxia signaling pathway, mitochondrial electron transport chain, and methylation status, suggesting that therapeutic regimen might be optimized by targeting these signature molecular pathways.

    Experimental Design: In the present study, we investigated the molecular signatures in clinical specimens from cluster I PCPGs in comparison to cluster II PCPGs that are related to kinase signaling and often present as benign tumors. Read More

    Acute Hypoxia Induces Enkephalin Production and Release in an Adrenergic Cell Line Model of Neonatal Chromaffin Cell Responses to Hypoxic Stress.
    Am J Perinatol 2018 Apr 10. Epub 2018 Apr 10.
    Department of Pediatrics, Stony Brook Children's Hospital, Stony Brook, New York.
    Objective:  Prior to maturation of the human sympathetic nervous system, the neonatal adrenal medulla senses and responds to hypoxia. In addition to catecholamine release, the adrenal medulla synthesizes and stores opioid peptides, notably enkephalin (ENK). However, it is not known whether acute hypoxia evokes adrenal ENK production and release, as seen in the central nervous system (CNS). Read More

    The dystrophin isoform Dp71e is involved in neurite outgrowth and neuronal differentiation of PC12 cells.
    J Proteomics 2018 Apr 3. Epub 2018 Apr 3.
    Departamento de Genética y Biología Molecular, Centro de Investigación y de Estudios Avanzados del IPN, Ciudad de México, Mexico. Electronic address:
    The Dp71 protein is the most abundant dystrophin in the central nervous system (CNS). Several dystrophin Dp71 isoforms have been described and are classified into three groups, each with a different C-terminal end. However, the functions of Dp71 isoforms remain unknown. Read More

    Endocr Pract 2018 Apr 6. Epub 2018 Apr 6.
    From: 1Department of Urology, Peking Union Medical College Hospital, Chinese Academy of Medical Science, Beijing, China.
    Objective: To explore the fever of unknown origin (FUO) resulted by Interleukin-6 (IL-6) producing pheochromocytoma.

    Material And Methods: Patients with pheochromocytoma were gathered from June 2014 to April 2017. The clinical characteristics of patients were recorded such as gender, age, 24hr urinary catecholamines (norepinephrine, epinephrine, dopamine), tumor size, axillary temperature (AT), white blood cells (WBC), serum IL-6 level and high sensitive C Reactive Protein (hsCRP). Read More

    Abdominal imaging findings in adult patients with Fontan circulation.
    Insights Imaging 2018 Apr 5. Epub 2018 Apr 5.
    Department of Medical Imaging, Toronto General Hospital, 585 University Avenue, Toronto, ON, M5G 2N2, Canada.
    The Fontan procedures, designed to treat paediatric patients with functional single ventricles, have markedly improved the patient's survival into adulthood. The physiology of the Fontan circuit inevitably increases systemic venous pressure, which may lead to multi-system organ failure in the long-term follow-up. Fontan-associated liver disease (FALD) can progress to liver cirrhosis with signs of portal hypertension. Read More

    Continued Tumor Reduction of Metastatic Pheochromocytoma/Paraganglioma Harboring Succinate Dehydrogenase Subunit B Mutations with Cyclical Chemotherapy.
    Cell Mol Neurobiol 2018 Apr 5. Epub 2018 Apr 5.
    Medical Oncology, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
    Patients harboring germline mutations in the succinate dehydrogenase complex subunit B (SDHB) gene present with pheochromocytomas and paragangliomas (PPGL) that are more likely malignant and clinically aggressive. The combination chemotherapy cyclophosphamide, vincristine, and dacarbazine (CVD) was retrospectively evaluated in patients with SDHB-associated metastatic PPGL.Query Twelve metastatic PPGL patients harboring SDHB mutations/polymorphisms with undetectable SDHB immunostaining were treated with CVD. Read More

    Concurrent primary hyperparathyroidism and pheochromocytoma in a Chinese lady with neurofibromatosis type 1.
    Endocrinol Diabetes Metab Case Rep 2018 28;2018. Epub 2018 Mar 28.
    Department of Medicine and Geriatrics, Caritas Medical Centre, Shamshuipo, Kowloon, Hong Kong SAR.
    We report a case of elderly Chinese lady with neurofibromatosis type-1 presenting with longstanding palpitation, paroxysmal hypertension and osteoporosis. Biochemical testing showed mild hypercalcaemia with non-suppressed parathyroid hormone level suggestive of primary hyperparathyroidism, and mildly elevated urinary fractionated normetanephrine and plasma-free normetanephrine pointing to a catecholamine-secreting pheochromocytoma/paraganglioma. Further scintigraphic investigation revealed evidence of a solitary parathyroid adenoma causing primary hyperparathyroidism and a left pheochromocytoma. Read More

    Uncommon presentation, rare complication and previously undescribed oncologic association of pheochromocytoma; the great masquerader.
    BMJ Case Rep 2018 Apr 5;2018. Epub 2018 Apr 5.
    Division of Cardiology, Department of Medicine, Johns Hopkins Hospital and Health System, Baltimore, Maryland, USA.
    We describe the case of a 67-year-old man presenting with ventricular tachycardia (VT) and systolic heart failure secondary to a left adrenal phaeochromocytoma. After treatment with amiodarone, the patient's VT resolved. However, his course was complicated by femoral deep venous thrombosis secondary to an incidentally discovered dedifferentiated liposarcoma of the thigh, for which he was prescribed a course of enoxaparin. Read More

    Pedigree analysis, diagnosis and treatment in Von Hippel-Lindau syndrome: A report of three cases.
    Oncol Lett 2018 Apr 5;15(4):4882-4890. Epub 2018 Feb 5.
    Department of Urology, Affiliated Hospital of Zunyi Medical College, Zunyi, Guizhou 563000, P.R. China.
    The objective of the present study was to systematically investigate the clinical features, diagnosis and therapeutic treatment of Von Hippel-Lindau (VHL) syndrome in order to improve understanding of this disease. A total of 3 cases of VHL syndrome treated at the Affiliated Hospital of Zunyi Medical College (Zunyi, China) between September 2014 and October 2015 were retrospectively analyzed. The associated literature was reviewed, and the diagnostic and therapeutic features were discussed. Read More

    Association between hypothyroidism and Takotsubo Cardiomyopathy: Analysis of Nationwide Inpatient Sample Database.
    Rev Recent Clin Trials 2018 Apr 2. Epub 2018 Apr 2.
    Department of Cardiology, Michigan State University/Borgess Medical Center, 1521 Gull Rd, Kalamazoo, MI 49048. United States.
    Background: Takotsubo cardiomyopathy (TC), also called transient left ventricular (LV) ballooning syndrome, satirizes myocardial infarction and is characterized by LV dysfunction in the absence of coronary artery disease. Hypothesis described for TC has been an intense social stressor, pheochromocytoma, thyrotoxicosis among others. We performed this study to analyze the association of hypothyroidism with TC. Read More

    Neoplasia in Three Aye-Ayes (Daubentonia madagascariensis).
    J Comp Pathol 2018 Feb 5;159:16-20. Epub 2018 Feb 5.
    Durrell Wildlife Conservation Trust, Les Augres Manor, La Profonde Rue, Trinity, Jersey.
    Tumours diagnosed in three aged captive aye-ayes (Daubentonia madagascariensis), held in two different institutions, are described. A cerebral glioblastoma was diagnosed based on histological and immunohistochemical findings in one of the animals following initial presentation with bilateral mydriasis, absent pupillary reflex, head tilt and ataxia. A second animal was humanely destroyed due to impaired locomotion associated with spondylosis and a post-mortem diagnosis of cholangiocarcinoma was made based on histology with further confirmation with immunohistochemical labelling for cytokeratin 7. Read More

    Genotype and phenotype correlation in von Hippel-Lindau disease based on alteration of the HIF-α binding site in VHL protein.
    Genet Med 2018 Mar 29. Epub 2018 Mar 29.
    Department of Urology, Peking University First Hospital, Beijing, P.R. China.
    PurposeVon Hippel-Lindau (VHL) disease is a rare hereditary cancer syndrome that reduces life expectancy. We aimed to construct a more valuable genotype-phenotype correlation based on alterations in VHL protein (pVHL).MethodsVHL patients (n = 339) were recruited and grouped based on mutation types: HIF-α binding site missense (HM) mutations, non-HIF-α binding site missense (nHM) mutations, and truncating (TR) mutations. Read More

    Autonomic nervous system and cancer.
    Clin Auton Res 2018 Mar 28. Epub 2018 Mar 28.
    Neuro-Oncology Unit, Hospital Universitari de Bellvitge-Catalan Institute of Oncology (ICO) l'Hospitalet, Bellvitge Institute for Biomedical Research (IDIBELL), Feixa Llarga s/n, 08907, L'Hospitalet de Llobregat, Barcelona, Spain.
    The autonomic nervous system (ANS) is the main homeostatic regulatory system of the body. However, this widely distributed neural network can be easily affected by cancer and by the adverse events induced by cancer treatments. In this review, we have classified the ANS complications of cancer into two categories. Read More

    Metastatic pheochromocytoma in MEN 2A: A rare association.
    BMJ Case Rep 2018 Mar 28;2018. Epub 2018 Mar 28.
    Department of Endocrinology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
    A 45-year-old woman was diagnosed as having multiple endocrine neoplasia type 2A in 2014. She had bilateral pheochromocytoma, medullary thyroid carcinoma and biopsy-proven cutaneous lichen amyloidosis in the interscapular area. She underwent bilateral adrenalectomy; following which, she achieved clinical and biochemical remission. Read More

    Bone Health in Adrenal Disorders.
    Endocrinol Metab (Seoul) 2018 Mar;33(1):1-8
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
    Secondary osteoporosis resulting from specific clinical disorders may be potentially reversible, and thus continuous efforts to find and adequately treat the secondary causes of skeletal fragility are critical to ameliorate fracture risk and to avoid unnecessary treatment with anti-osteoporotic drugs. Among the hyperfunctional adrenal masses, Cushing's syndrome, pheochromocytoma, and primary aldosteronism are receiving particularly great attention due to their high morbidity and mortality mainly by increasing cardiovascular risk. Interestingly, there is accumulating experimental and clinical evidence that adrenal hormones may have direct detrimental effects on bone metabolism as well. Read More

    Intracranial Epidural Metastases of Adrenal Pheochromocytoma: A Rare Entity.
    World Neurosurg 2018 Mar 24. Epub 2018 Mar 24.
    Department of Neurosurgery, Clinical Neurosciences Center. Electronic address:
    Pheochromocytomas are uncommon neuroendocrine tumors of the adrenal medulla. Malignant behavior is seen in approximately 10% of these lesions, evidenced by distant metastasis to sites without chromaffin tissue. The authors report a rare case of intracranial epidural metastases of an adrenal pheochromocytoma in a 24-year-old man. Read More

    Spontaneous adrenocorticotropic hormone (ACTH) normalisation due to tumour regression induced by metyrapone in a patient with ectopic ACTH syndrome: case report and literature review.
    BMC Endocr Disord 2018 Mar 27;18(1):19. Epub 2018 Mar 27.
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Aichi Medical University, School of Medicine, Nagakute, Japan.
    Background: Ectopic adrenocorticotropic hormone (ACTH) syndrome (EAS) is caused by tumours releasing ACTH. Ectopic ACTH-producing tumour regression is rarely induced using steroidogenesis inhibitors. We presented a case of EAS in which ACTH production by a lung tumour was reduced by metyrapone (MTP) and also reviewed previous cases of ectopic ACTH production suppressed via steroidogenesis inhibition. Read More

    Barriers to the recognition of medullary thyroid carcinoma on FNA: Implications relevant to the new American Thyroid Association guidelines.
    Cancer Cytopathol 2018 Mar 26. Epub 2018 Mar 26.
    Department of Pathology, Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, Ohio.
    Background: The 2016 American Thyroid Association guidelines recommend multiple endocrine neoplasia testing and evaluation for pheochromocytoma before thyroidectomy after a thyroid fine-needle aspiration biopsy (FNA) is positive for medullary thyroid carcinoma (MTC). In the current study, the authors examined the reasons why FNA was unable to definitively diagnose MTC preoperatively, with attention to morphologic patterns that can be misleading.

    Methods: Cases of MTC diagnosed on thyroid surgical resection for which there was a prior FNA and slides available for review were included (28 cases). Read More

    An unusual case of hematemesis and epistaxis caused by a pheochromocytoma.
    J Int Med Res 2018 Jan 1:300060518765015. Epub 2018 Jan 1.
    6 Department of Medical Biochemistry (Firat Hormones Research Group), School of Medicine, Firat University, Elazig, Turkey.
    Pheochromocytoma is a rare catecholamine-secreting neoplasm that is the cause of hypertension in <0.2% of patients with hypertension. We encountered an unusual case of pheochromocytoma involving hematemesis and epistaxis episodes with accompanying hypertensive attacks. Read More

    Adrenomedullin: Continuing to explore cardioprotection.
    Peptides 2018 Mar 22. Epub 2018 Mar 22.
    Department of Internal Medicine, Circulatory and Body Fluid Regulation, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692, Japan.
    Adrenomedullin (AM), a peptide isolated from an extract of human pheochromocytoma, comprises 52 amino acids with an intramolecular disulfide bond and amidation at the carboxy-terminus. AM is present in various tissues and organs in rodents and humans, including the heart. The peptide concentration increases with cardiac hypertrophy, acute myocardial infarction, and overt heart failure in the plasma and the myocardium. Read More

    Clinical safety of percutaneous ultrasound-guided fine-needle aspiration of adrenal gland lesions in 19 dogs.
    J Small Anim Pract 2018 Mar 25. Epub 2018 Mar 25.
    Melbourne Veterinary School, Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Melbourne, Victoria, 3030, Australia.
    Objective: To evaluate the safety of fine-needle aspiration of adrenal gland lesions in dogs and to characterise the risks in a subset of patients with cytologically or histopathologically diagnosed phaeochromocytoma.

    Materials And Methods: Retrospective review of medical records of dogs that underwent percutaneous ultrasound-guided fine-needle aspiration of adrenal gland lesions between August 2014 and December 2016. Nineteen dogs were identified, with three undergoing bilateral adrenal gland aspiration and one dog undergoing aspiration twice, yielding 23 cytology samples in total. Read More

    Antioxidative Effect of Quetiapine on Acute Ultraviolet-B-Induced Skin and HaCaT Cell Damage.
    Int J Mol Sci 2018 Mar 23;19(4). Epub 2018 Mar 23.
    Key Laboratory of Construction and Detection in Tissue Engineering of Guangdong Province, Department of Histology and Embryology, School of Basic Medical Sciences, Southern Medical University, No. 1023-1063 Sha Tai Road, Baiyun District, Guangzhou 510515, China.
    Quetiapine is a new type of antipsychotic drug, with effective protection of pheochromocytoma PC12 cells from oxidative stress-induced apoptosis. Ultraviolet-B radiation can increase reactive oxygen species (ROS) production, resulting in significant inflammatory responses in damaged skin. Thus, the purpose of this study is to explore whether quetiapine protects the skin from intermediate-wave ultraviolet (UVB)-induced damage through antioxidant stress. Read More

    Pheochromocytomas Versus Adenoma: Role of Venous Phase CT Enhancement.
    AJR Am J Roentgenol 2018 Mar 23:1-6. Epub 2018 Mar 23.
    1 Department of Radiology, Vancouver General Hospital, 899 W 12th Ave, Vancouver, BC V5Z 1M9, Canada.
    Objective: Our objective was to investigate whether the quantitative measurement of venous phase enhancement on CT can distinguish a pheochromocytoma from an adrenal adenoma.

    Materials And Methods: A pathology database was retrospectively appraised over a period of 7 years and revealed 43 histopathologically proven adrenal adenomas and 34 pheochromocytomas. The lesion densities were measured on the 60-second venous phase CT on all adrenal lesions to assess venous phase enhancement values. Read More

    Laparoscopic management of paraganglioma in a pregnant woman: a case report.
    Int Braz J Urol 2018 Mar 23;44. Epub 2018 Mar 23.
    Urology and Nephrology Research Center, Shahid Labbafinejad Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
    Introduction: Paraganglioma is an extremely rare catecholamine-producing tumor during pregnancy. Paraganglioma carries high risks of fetal and maternal mortality during pregnancy. We report a pregnant woman with paraganglioma in the second trimester. Read More

    Ga-somatostatin receptor analogs and F-FDG PET/CT in the localization of metastatic pheochromocytomas and paragangliomas with germline mutations: a meta-analysis.
    Acta Radiol 2018 Jan 1:284185118764206. Epub 2018 Jan 1.
    2 Department of Radiology, Beijing Friendship Hospital, 26455 Capital Medical University , Beijing, PR China.
    Background Metastatic pheochromocytoma and paraganglioma (PCs/PGLs) show high germline mutation, and F-FDG and Ga-DOTA peptide positron emission tomography/computed tomography (PET/CT) imaging are recommended for the diagnosis of metastatic of PCs. However, there has been lack of direct comparison of the two modalities in the diagnosis of metastatic of PCs up to now. Purpose To evaluate and compare the value of localization of Ga-somatostatin receptor analogs and F-FDG in the diagnosis of metastatic PCs/PGLs. Read More

    Propofol Prevents the Progression of Malignant Pheochromocytoma In Vitro and In Vivo.
    DNA Cell Biol 2018 Apr 22;37(4):308-315. Epub 2018 Mar 22.
    3 Department of Medicine, Harbin Medical University Affiliated 3rd Hospital , Harbin, China .
    This study aimed to explore the efficacy of propofol to treat malignant pheochromocytoma (PCC) in vitro and in vivo. In vitro, PC12 cells were treated with different concentrations of propofol (0, 1, 5, and 10 μg/mL) for specific times followed by a MTT assay to detect cell proliferation. Transwell assays were performed to assess the function of propofol on the migration and invasion of PC12 cells, and flow cytometry to analyze cell apoptosis and cell cycle progression. Read More

    Correction to: Pheochromocytoma diagnosed during pregnancy: lessons learned from a series of ten patients.
    Surg Endosc 2018 Mar 20. Epub 2018 Mar 20.
    Department of Endocrine Surgery, Ukrainian Scientific and Practical Center for Endocrine Surgery of Public Health Ministry of Ukraine, Kiev, Ukraine.
    The original article was updated to correct the listing of A. Hamy's name; it is correct as displayed above. Read More

    Ndr2 Kinase Controls Neurite Outgrowth and Dendritic Branching Through α Integrin Expression.
    Front Mol Neurosci 2018 6;11:66. Epub 2018 Mar 6.
    Department of Genetics and Molecular Neurobiology, Institute of Biology, Otto-von-Guericke University Magdeburg, Magdeburg, Germany.
    The serine/threonine kinase Ndr2 has been shown to control the inside-out activation of the βsubunit of integrins and the formation of neurites in both primary neurons and neurally differentiated pheochromacytoma (PC12) cells. In this study, we demonstrate that Ndr2 kinase furthermore determines the substrate specificity of neurite extension in PC12 cells via expression of αβ integrins. We show that stable overexpression of Ndr2 in PC12 cells increases neurite growth and extension on poly-D-lysine substrate, likely involving an increased expression of active β integrin in the growth tips of these cells. Read More

    External beam radiation therapy for advanced/unresectable malignant paraganglioma and pheochromocytoma.
    Adv Radiat Oncol 2018 Jan-Mar;3(1):25-29. Epub 2017 Nov 22.
    Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota.
    Purpose/objectives: To evaluate the role of external beam radiation therapy (EBRT) for treatment of malignant paraganglioma (PGL) and pheochromocytoma (PCC).

    Methods And Materials: A retrospective review was performed of all patients with malignant PGL/PCC treated with EBRT at our institution between 1973 and 2015. Local control (LC) per treated lesion and overall survival were estimated using the Kaplan-Meier method. Read More

    Unsuspected pheochromocytoma incidentally found on chest CT.
    Radiol Case Rep 2018 Feb 6;13(1):191-196. Epub 2017 Nov 6.
    Thomas Jefferson University Hospital, 111 South 11th Street, Philadelphia, PA 19107, USA.
    A 51-year-old woman with history of migraine headaches and intermittent nausea, vomiting, palpitations, and diaphoresis presented to the emergency department with hypertensive emergency 1 month after starting a beta blocker for migraine prophylaxis. Contrast-enhanced computed tomography of the chest incidentally revealed a large abdominal mass in the area of the left adrenal gland. Iodine-123 metaiodobenzylguanidine scan imaging showed localized uptake into the left adrenal gland. Read More

    Abass Alavi: A giant in Nuclear Medicine turns 80 and is still going strong!
    • Authors:
    Hell J Nucl Med 2017 Mar 20. Epub 2017 Mar 20.
    Little was written in the stars above the city of Tabriz in Iran on March 15, 1938 indicating that a newborn citizen would immigrate to America and become a master of modern mo-lecular imaging with a sharp focus on F-FDG PET to the benefit of millions of people around the world. Nonetheless, that's what happened. A gifted boy who lost his farther early and grew up with his uneducated mother and two siblings in humble circumstances to become a premium student, nationally no. Read More

    Current diagnostic imaging of pheochromocytomas and implications for therapeutic strategy.
    Exp Ther Med 2018 Apr 14;15(4):3151-3160. Epub 2018 Feb 14.
    Department of Radiology, University Hospital and Faculty of Medicine and Dentistry, Palacky University, 779 00 Olomouc, Czech Republic.
    The topic of pheochromocytomas is becoming increasingly popular as a result of major advances in different medical fields, including laboratory diagnosis, genetics, therapy, and particularly in novel advances in imaging techniques. The present review article discusses current clinical, biochemical, genetic and histopathological aspects of the diagnosis of pheochromocytomas and planning of pre-surgical preparation and subsequent surgical treatment options. The main part of the paper is focused on the role of morphological imaging methods (primarily computed tomography and magnetic resonance imaging) and functional imaging (scintigraphy and positron emission tomography) in the diagnosis and staging of pheochromocytomas. Read More

    Multifocal Paraganglioma and Pheochromocytoma Due to Truncated SDHD Mutation.
    Urology 2018 Mar 12. Epub 2018 Mar 12.
    Department of Urology Surgery, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China. Electronic address:
    Objective: Pheochromocytoma and paraganglioma (PPGL) are rare autosomal dominant disorders derived from the neural crest chromaffin tissues of the autonomic nervous system. The succinate dehydrogenase complex subunit D (SDHD) gene has been implicated as one of the pathogenic genes. Although more than 100 SDHD mutations have been reported, the phenotype-genotype association remains unclear. Read More

    Metastatic Pheochromocytoma in an Asymptomatic 12-Year-Old With von Hippel-Lindau Disease.
    Urology 2018 Mar 12. Epub 2018 Mar 12.
    Department of Surgery, Division of Urology, University of Colorado, Aurora, CO. Electronic address:
    Pheochromocytoma is a rare chromaffin cell tumor that may be associated with a genetic predisposition, such as von Hippel-Lindau (VHL) disease. VHL is an autosomal dominant disorder that is characterized by a predisposition to multiple tumors, including retinal and central nervous system hemangioblastomas, renal cell carcinoma, and pheochromocytomas. The classic presentation of pheochromocytoma is episodic hypertension, headaches, palpitations, and diaphoresis. Read More

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