23,620 results match your criteria Pheochromocytoma


Perioperative outcomes of pheochromocytoma/paraganglioma surgery preceded by Takotsubo-like cardiomyopathy.

Surgery 2022 May 16. Epub 2022 May 16.

Department of Digestive, Hepato-biliary and Endocrine Surgery, Referral Center for Rare Adrenal Diseases, Cochin Hospital, APHP, Paris, France; Department of Hepato-Biliary and Pancreatic Surgery and Liver Transplantation, AP-HP Pitié-Salpêtrière Hospital, Paris, France; Department of General, Visceral, and Endocrine Surgery, Pitié-Salpêtrière Hospital, AP-HP, Paris, France; Sorbonne University, Paris, France. Electronic address:

Background: Pheochromocytomas and paragangliomas can induce severe cardiovascular manifestations such as Takotsubo-like cardiomyopathy. What the perioperative outcomes are of patients presenting with pheochromocytomas/paragangliomas preceded by Takotsubo-like cardiomyopathy remains an unresolved question.

Methods: From 2006 to 2019, all patients who underwent surgery for pheochromocytomas/paragangliomas preceded by Takotsubo-like cardiomyopathy were included from 3 high-volume centers, with specific attention to perioperative hemodynamic instability and postoperative outcomes. Read More

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Pheochromocytoma-Induced Cardiogenic Shock.

Acta Chir Belg 2022 May 18:1-5. Epub 2022 May 18.

Department of Abdominal Surgery, Grand Hôpital de Charleroi, Gilly, Belgium.

Background: Pheochromocytoma is a rare catecholamine-secreting tumor of neuroendocrine origin. It has a prevalence of <1% in adults with hypertension. In some cases, hypertension is associated with the classical triad of headache, sweating, and tachycardia. Read More

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A Four-Generational Report on Hereditary Head and Neck Paraganglioma.

Cureus 2022 Apr 14;14(4):e24143. Epub 2022 Apr 14.

Otolaryngology - Head and Neck Surgery, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, DEU.

Background This article investigates the inheritance, penetrance, clinical presentation, and therapeutic outcomes of hereditary head and neck paragangliomas (HNPGLs) by offering a four-generational report of an 18-member family affected by this rare condition. Methodology Information was compiled by examination of patients and a review of medical records and correspondence (retrospective case series). Results Six members of the 18-member family were diagnosed with HNPGL between 2002 and 2018. Read More

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Aorto-iliac paraganglioma: Case report and literature review.

Int J Surg Case Rep 2022 Apr 22;95:107119. Epub 2022 Apr 22.

Department of Surgery, Hospital Universitario Fundación Santa Fe de Bogotá, 110111, Bogotá D.C., Colombia; School of Medicine, Universidad de los Andes, 111711 Bogotá D.C., Colombia.

Introduction: Paraganglioma and pheochromocytoma are uncommon conditions that affect around 1.5-9 patients per million. The most frequent symptoms are headache, hypertension and diaphoresis; however, palpitations or tachycardia could be present. Read More

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Recurrent ipsilateral pheochromocytoma in carriers of RET p.Cys634 missense mutations.

Endocrine 2022 May 17. Epub 2022 May 17.

Medical Faculty, Department of Visceral, Vascular and Endocrine Surgery, Martin Luther University Halle-Wittenberg, Ernst-Grube-Str. 40, D-06097, Halle (Saale), Germany.

Purpose: The objective of this study was to provide RET genotype-specific data on recurrent ipsilateral pheochromocytoma in multiple endocrine neoplasia type 2A (MEN2A), which are sparse.

Methods: Kaplan-Meier analyses were performed to determine the risk of recurrent ipsilateral adrenalectomy after subtotal and total adrenalectomy in 221 carriers of RET p.Cys634 missense mutations. Read More

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Value of Immunohistochemical Expression of Apelin, Succinate Dehydrogenase B, Chromogranin B, Human Epidermal Growth Factor Receptor-2, Contactin 4, and Succinyl-CoA Synthetase Subunit Beta in Differentiating Metastatic From Non-Metastatic Pheochromocytoma and Paraganglioma.

Front Endocrinol (Lausanne) 2022 28;13:882906. Epub 2022 Apr 28.

Department of Urology, Xiangya Hospital, Central South University, Changsha, China.

Objective: We aimed to retrospectively collect pathologically identified pheochromocytoma and paraganglioma (PPGL) tumor tissues from our center and investigate the expression of apelin and succinyl-CoA synthetase subunit beta (SUCLG2), human epidermal growth factor receptor-2 (HER2 or ERBB-2), contactin 4 (CNTN4), chromogranin B (CHGB), and succinate dehydrogenase B (SDHB) in metastatic and non-metastatic PPGLs, for exploring their roles in the diagnosis of metastatic PPGLs.

Methods: A total of 369 patients with pathologically and surgically confirmed PPGLs at Xiangya Hospital, Central South University, between June 2010 and June 2020 were retrospectively included. Sixty patients-12 patients with metastatic PPGLs and 48 patients with non-metastatic PPGLs-were selected through propensity score matching (1:4) to reduce the effect of PPGL type, sex, and age. Read More

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Study of tRNA-Derived Fragment tRF-20-S998LO9D in Pan-Cancer.

Dis Markers 2022 5;2022:8799319. Epub 2022 May 5.

Department of Blood Transfusion, The Third Xiangya Hospital of Central South University, Changsha 410013, China.

Objective: The purpose is to study the effect of tRNA-derived fragments (tRFs) on pan-cancer through bioinformatics.

Methods: The expression information of tRF-20-S998LO9D, a type of tRF-5, was retrieved through MINTbase in pan-cancer and verified by qPCR. We preliminarily explored the effect of tRF-20-S998LO9D on cell proliferation in breast cancer and lung cancer cell lines. Read More

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Laparoscopic versus robotic adrenalectomy in pheochromocytoma patients.

J Surg Oncol 2022 May 14. Epub 2022 May 14.

Department of Endocrine Surgery, Cleveland Clinic, Cleveland, Ohio, USA.

Background And Objectives: Pheochromocytoma is a challenging tumor type requiring resection with a clear margin and an intact capsule to prevent recurrences. Our aim was to compare perioperative outcomes of laparoscopic adrenalectomy (LA) versus robotic adrenalectomy (RA) for pheochromocytoma.

Methods: In an institutional review board-approved retrospective study, clinical parameters of patients who underwent LA versus RA at a single center were compared using Mann-Whitney U, χ , and survival analyses. Read More

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Management of Pheochromocytomas and Paragangliomas: A Case-Based Review of Clinical Aspects and Perspectives.

J Clin Med 2022 May 5;11(9). Epub 2022 May 5.

Department of Oncology and Radiotherapy, Medical University of Gdansk, 80-214 Gdansk, Poland.

Paraganglioma and pheochromocytoma are rare medical conditions. Thus, there are still a small number of studies, clinical trials, and evidence-based data in this field. This makes clinical decisions more difficult. Read More

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Current Sample Preparation Methodologies for Determination of Catecholamines and Their Metabolites.

Molecules 2022 Apr 22;27(9). Epub 2022 Apr 22.

Key Laboratory of Targeting Therapy and Diagnosis for Critical Diseases of Henan Province, School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China.

Catecholamines (CAs) and their metabolites play significant roles in many physiological processes. Changes in CAs concentration in vivo can serve as potential indicators for the diagnosis of several diseases such as pheochromocytoma and paraganglioma. Thus, the accurate quantification of CAs and their metabolites in biological samples is quite important and has attracted great research interest. Read More

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Balloon catheter as an extraction device for caudal vena cava adrenal tumor thrombectomy in a dog: A case report.

Vet Surg 2022 May 12. Epub 2022 May 12.

Animal Surgical Center of Michigan, Flint, Michigan, USA.

Objective: To report the use of a balloon catheter as an extraction device for a posthepatic caval thrombus in a dog with a right adrenal tumor.

Animals: Twelve-year-old male neutered Chihuahua mix dog.

Study Design: Case report METHODS: The dog presented for the evaluation of a hepatic mass. Read More

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Cushing syndrome due to ectopic ACTH secreting pheochromocytoma.

BMJ Case Rep 2022 May 11;15(5). Epub 2022 May 11.

Tabba Heart Institute, Karachi, Pakistan

In this case report, we present a case of a woman in her late 30s who presented with bilateral motor weakness, headache, hyperglycaemia and hypertension. Investigations revealed very high 24-hour urine cortisol of 90 524, ectopic adrenocorticotropic hormone secreting pheochromocytoma, normal metanephrine levels and empty sella, which has never been reported. CT chest and abdomen revealed enlarged left adrenal gland with large necrotic mass 4. Read More

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Successful extracorporeal membrane oxygenation treatment of catecholamine-induced cardiomyopathy-associated pheochromocytoma.

Acute Crit Care 2022 May 11. Epub 2022 May 11.

Regional Cardiovascular Disease Center, Chungbuk National University Hospital, Cheongju, Korea.

The main mechanism of Takotsubo cardiomyopathy (TCM) is catecholamine-induced acute myocardial stunning. Pheochromocytoma, a catecholamine-secreting tumor, can cause several cardiovascular complications, including hypertensive crisis, myocardial infarction, toxic myocarditis, and TCM. A 29-year-old woman presented to our hospital with general weakness, vomiting, dyspnea, and chest pain. Read More

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Presurgical planning of 3D printing for a large abdominal pheochromocytoma and paraganglioma.

Urology 2022 May 7. Epub 2022 May 7.

Department of urology, The Second Xiangya Hospital, Central South University, P. R. C China. Electronic address:

Objective: To determine the significance of presurgical planning of three-dimensional (3D) printing for resection of a large abdominal pheochromocytoma (PCC) and paraganglioma (PGL).

Patients And Methods: Thirty patients were enrolled in the present study. Groups A and B included 15 patients each. Read More

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Functional imaging of neuroendocrine tumors: stacking the odds in a patient's favor.

J Clin Endocrinol Metab 2022 May 10. Epub 2022 May 10.

Section on Medical Neuroendocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Building 10, CRC, Room 1E-3140, 10 Center Drive MSC-1109, Bethesda, Maryland 20892-1109, US.

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Inter-individual comparison of diagnostic accuracy of adrenal washout CT compared to chemical shift MRI plus the T2-weighted (T2W) adrenal MRI calculator in indeterminate adrenal masses: a retrospective non-inferiority study.

Abdom Radiol (NY) 2022 May 10. Epub 2022 May 10.

Department of Medical Imaging, The Ottawa Hospital, University of Ottawa, 1053 Carling Avenue, C1 Radiology, Ottawa, ON, K1Y 4E9, Canada.

Objective: To compare diagnostic accuracy of washout (WO)-CT to chemical shift (CS)-MRI + T2W adrenal MRI Calculator (T2W-Calculator) to diagnose adrenal adenoma in indeterminate adrenal masses.

Methods: This retrospective, cross-sectional, non-inferiority study evaluated 40 consecutive indeterminate adrenal masses; each with WO-CT and MRI. Two blinded radiologists independently evaluated in mixed order: pre-contrast attenuation (Hounsfield Units, HU) and absolute WO ([Peak. Read More

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Anaesthetic management of a dopamine-secreting phaeochromocytoma.

Rev Esp Anestesiol Reanim (Engl Ed) 2022 May 6. Epub 2022 May 6.

Servicio de Anestesiología y Reanimación, Hospital Clínico Universitario de Valladolid, Valladolid, Spain.

Pheochromocytomas are rare neuroendocrine tumors that arise from chromaffin cells of the adrenal medulla. Most adrenal pheochromocytomas secrete norepinephrine and epinephrine. Dopamine secreting pheochromocytomas are extremely rare and differs from classic pheochromocytomas in clinical features, posing a significant diagnostic challenge. Read More

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Adrenal Surgery in the Era of Multidisciplinary Endocrine Tumor Boards.

Horm Metab Res 2022 May 9;54(5):294-299. Epub 2022 May 9.

Department of General, Visceral, Cancer and Transplant Surgery, University Hospital Cologne, Cologne, Germany.

Work up of adrenal masses includes assessment of endocrine activity and malignancy risk. There is no indication for surgical removal of nonfunctional adrenal adenomas, according to the guidelines. In the present study, we aimed at evaluating the impact of a university endocrine tumor board on the quality of the indications for adrenal surgery at our institution. Read More

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Laparoscopic sleeve gastrectomy with adrenalectomy, feasibility, safety and outcome.

J Surg Case Rep 2022 May 5;2022(5):rjac130. Epub 2022 May 5.

Department of Surgery, College of Medicine, King Saud University, Riyadh, Saudi Arabia.

Concomitant surgery is an attractive option because of convenience. To our knowledge, this is the first study reporting concomitant laparoscopic sleeve gastrectomy (LSG) and laparoscopic right adrenalectomy. A retrospective review of three patients with obesity and a unilateral adrenal mass was conducted. Read More

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Adrenal pheochromocytoma in a patient with Lynch Syndrome.

Urol Case Rep 2022 May 3;42:102015. Epub 2022 Feb 3.

Department of Urology, The James Buchanan Brady Urological Institute, The Johns Hopkins University School of Medicine, USA.

Lynch Syndrome (LS), or hereditary non-polyposis colorectal cancer, is the most common cause of hereditary colorectal cancer. There are well described extra-colonic manifestations of LS, including gynecologic and upper urinary tract malignancies. Other extra-colonic manifestations of LS are less understood. Read More

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Cystic pheochromocytoma leading to multisystem crisis: A silent and hazardous neoplasm.

Asian J Surg 2022 May 5. Epub 2022 May 5.

Division of Urology, Department of Surgery, Far Eastern Memorial Hospital, New Taipei City, Taiwan. Electronic address:

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225Ac-DOTATATE therapy in a case of metastatic pheochromocytoma.

Eur J Nucl Med Mol Imaging 2022 May 6. Epub 2022 May 6.

Department of Nuclear Medicine, The Affiliated Hospital of Southwest Medical University, No. 25 Taiping St., Jiangyang DistrictSichuan, Luzhou, 646000, People's Republic of China.

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Bilateral pheochromcytomas presenting as shock: A rare case report.

J Family Med Prim Care 2022 Apr 18;11(4):1528-1531. Epub 2022 Mar 18.

Department of Cardiology, Shree Krishna Hospital and Pramukhswami Medical College, Karamsad, Gujarat, India.

Pheochromocytomas are rare chromaffin cell tumors of adrenal medulla (90%) that secrete catecholamines. Among children, the average age of presentation is 11-13 years, with a male preponderance of 2:1. Symptoms may be caused by catecholamine overproduction, local pressure, or metastasis. Read More

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Notoginsenoside R1 alleviates spinal cord injury through the miR-301a/KLF7 axis to activate Wnt/β-catenin pathway.

Open Med (Wars) 2022 13;17(1):741-755. Epub 2022 Apr 13.

Department of Orthopaedics, The First Hospital of Changsha, No. 311, Yingpan Road, Kaifu District, Changsha 410005, Hunan, China.

Spinal cord injury (SCI) is a devastating incident that induces neuronal loss and dysfunction. Notoginsenoside R1 (NGR1) has been reported to exhibit a neuroprotective role after SCI. In this study, the effect and molecular mechanisms of NGR1 in models of SCI were further investigated. Read More

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Metastatic Pheochromocytoma Diagnosed with I-MIBG SPECT/CT Imaging in a Patient with Pathogenic VHL Mutation.

World J Nucl Med 2022 Mar 30;21(1):73-75. Epub 2022 Apr 30.

Department of Endocrinology, Yashoda Hospital, Secunderabad, Telangana, India.

Pheochromocytoma is a rare catecholamine secreting neuroendocrine tumor arising from chromaffin cells of adrenal medulla with approximate prevalence of 0.1 to 0.6% in patients suffering from hypertension. Read More

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Functional imaging for evaluation of cancers and biologically conformal radiotherapy: Past-history and present-day perspectives.

Authors:
Jean Lumbroso

Presse Med 2022 Apr 29:104124. Epub 2022 Apr 29.

Service de Médecine Nucléaire, Gustave Roussy Cancer Campus, 114, rue Édouard-Vaillant 94805 Villejuif Cedex, France. Electronic address:

Over the past twenty years, nuclear medicine has enhanced the role of functional imaging in cancerology. A major milestone was achieved in the early 2000s with widespread availability of the positron emitter tracer 18F- deoxyglucose (FDG) and the introduction of hybrid imagers, i.e. Read More

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Hemodynamics in Patients With Pheochromocytoma or Paraganglioma Undergoing Non-Neuroendocrine Operations.

J Surg Res 2022 Apr 29;277:189-199. Epub 2022 Apr 29.

Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, Minnesota. Electronic address:

Introduction: Surgical resection of pheochromocytoma and paraganglioma (PPGL) may be associated with excessive hemodynamic variability. Whether hemodynamic variability occurs in patients with undiagnosed PPGL undergoing unrelated, non-neuroendocrine, operations is unknown.

Methods: We identified patients who underwent non-neuroendocrine surgical procedures up to 5 y before pathologic diagnosis of PPGL. Read More

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Determinants of disease-specific survival in patients with and without metastatic pheochromocytoma and paraganglioma.

Eur J Cancer 2022 Apr 29;169:32-41. Epub 2022 Apr 29.

Department of Medicine ΙΙI, University Hospital Carl Gustav Carus at the TU Dresden, Dresden, Germany; Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Carl Gustav Carus at the TU Dresden, Germany.

Background: Pheochromocytomas and paragangliomas (PPGLs) have a heterogeneous prognosis, the basis of which remains unclear. We, therefore, assessed disease-specific survival (DSS) and potential predictors of progressive disease in patients with PPGLs and head/neck paragangliomas (HNPGLs) according to the presence or absence of metastases.

Methods: This retrospective study included 582 patients with PPGLs and 57 with HNPGLs. Read More

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Pheochromocytoma Mimicking Acute Coronary Syndrome: A Case Report.

Front Oncol 2022 13;12:879714. Epub 2022 Apr 13.

Department of Emergency, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, People's Hospital of Henan University, Zhengzhou, China.

Pheochromocytoma is a rare catecholamine-secreting tumor with highly variable clinical presentations. We herein report a patient who presented to the emergency department with precordia pain, elevated myocardial enzymes, T-wave inversions on electrocardiogram and segmental ventricular wall motion abnormalities on echocardiography, which is normally managed as suspected acute coronary syndrome (ACS). However, the urgent coronary angiography showed normal coronary arteries. Read More

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1,2-Dimyristoyl--3-phosphocholine promotes the adhesion of nanoparticles to bio-membranes and transport in rat brain.

RSC Adv 2021 Oct 3;11(56):35455-35462. Epub 2021 Nov 3.

Guangxi Engineering Research Center of Digital Medicine and Clinical Translation, College of Biotechnology, Affiliated Hospital of Guilin Medical University, Guilin Medical University Guilin Guangxi 541004 China.

1,2-Dimyristoyl--3-phosphocholine (DMPC) coated on the surface of superparamagnetic iron oxide nanoparticles (SPIONs) has advantages in neurotherapy and drug delivery. In this study, the surface of polyvinylpyrrolidone (PVP)-SPIONs was modified with DMPC, then PVP-SPIONs and DMPC/PVP-SPIONs were co-incubated with rat adrenal pheochromocytoma (PC-12) cells to observe the effect of DMPC on the distribution of SPIONs in cells, and further PVP-SPIONs and DMPC/PVP-SPIONs were implanted into the substantia nigra of Sprague-Dawley (SD) rats by stereotaxic injection, and the brain tissues were removed at both twenty-four hours and seven days after injection. The distribution and transport of nanoparticles in the substantia nigra were explored in these different time periods. Read More

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October 2021