22,342 results match your criteria Pheochromocytoma


Pheochromocytomas and paragangliomas in children: Data from the Italian Cooperative Study (TREP).

Pediatr Blood Cancer 2020 Jun 3:e28332. Epub 2020 Jun 3.

Pediatric Surgery Unit, Department of Women's and Children's Health, University Hospital of Padua, Padua, Italy.

Background: Pheochromocytomas (PCs) are neuroendocrine tumors arising from the chromaffin cells of the adrenal gland, and paragangliomas (PGLs) are their extra-adrenal counterparts arising from ganglia along the sympathetic/parasympathetic chain. Surgery is the cornerstone of treatment. A sporatic or inherited germline mutation is commonly associated. Read More

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http://dx.doi.org/10.1002/pbc.28332DOI Listing

Laparoscopic excision of a large Adrenal Ganglioneuroma masquerading as Pheochromocytoma- A case report & review of literature.

Urol Case Rep 2020 Nov 22;33:101276. Epub 2020 May 22.

Department of Urology, All India Institute of Medical Sciences, Bhubaneswar, India.

Adrenal Ganglioneuromas are rare. Evaluation for hormone secretion followed by complete excision is the treatment of choice for such masses. We present our experience of a symptomatic large Adrenal Ganglioneuroma, which was removed with laparoscopic procedure. Read More

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http://dx.doi.org/10.1016/j.eucr.2020.101276DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7262088PMC
November 2020

Recurrence of Pheochromocytoma With Metastases After Resection of Primary Tumor.

Cureus 2020 May 28;12(5):e8328. Epub 2020 May 28.

Endocrinology, Diabetes and Metabolism, Rochester General Hospital, Rochester, USA.

Pheochromocytomas and paragangliomas are rare tumors that arise from the chromaffin cells of the adrenal medulla or sympathetic paravertebral ganglia, respectively. Long-term surveillance is recommended regardless of the thoroughness of surgical resection. Here, we present a patient who was diagnosed with pheochromocytoma who underwent right adrenalectomy and was lost to follow up. Read More

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http://dx.doi.org/10.7759/cureus.8328DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7255549PMC

Malaysian macroalga Hauck attenuates high dose corticosterone-mediated oxidative damage in PC12 cells mimicking the effects of depression.

Saudi J Biol Sci 2020 Jun 30;27(6):1435-1445. Epub 2020 Apr 30.

Department of Anatomy, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia.

Oxidative damage has been associated with the pathophysiology of depression. Macroalgae are equipped with antioxidant defense system to counteract the effects of free radicals We explored the use of Malaysian to attenuate high dose corticosterone-mediated oxidative damage in a cellular model mimicking depression. Fresh specimen of was freeze-dried and extracted sequentially with hexanes, ethyl acetate and ethanol. Read More

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http://dx.doi.org/10.1016/j.sjbs.2020.04.042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7254034PMC

Correction to: MEN2-related pheochromocytoma: current state of knowledge, specific characteristics in MEN2B, and perspectives.

Endocrine 2020 Jun 2. Epub 2020 Jun 2.

Department of Endocrinology, Aix-Marseille University, INSERM U1251, Endo-ERN Reference Center for Rare Genetic Tumor Syndromes, Assistance Publique-Hopitaux de Marseille, Marseille, France.

An amendment to this paper has been published and can be accessed via a link at the top of the paper. Read More

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http://dx.doi.org/10.1007/s12020-020-02365-7DOI Listing

The Changing Paradigm of Head and Neck Paragangliomas: What Every Otolaryngologist Needs to Know.

Ann Otol Rhinol Laryngol 2020 Jun 2:3489420931540. Epub 2020 Jun 2.

Department of Otolaryngology, University of Colorado School of Medicine, Aurora, CO, USA.

Background: Recommendations regarding head and neck paragangliomas (HNPGL) have undergone a fundamental reorientation in the last decade as a result of increased understanding of the genetic and pathophysiologic basis of these disorders.

Objective: We aim to provide an overview of HNPGL and recent discoveries regarding their molecular genetics, along with updated recommendations on workup, treatment, and surveillance, and their implications for otolaryngologists treating patients with these disorders.

Results: susceptibility gene mutations, encoding subunits of the enzyme succinate dehydrogenase (SDH), give rise to the Hereditary Pheochromocytoma/Paraganglioma Syndromes. Read More

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http://dx.doi.org/10.1177/0003489420931540DOI Listing

[Recurrent Takotsubo syndrome associated with pheochromocytoma: a case report].

Zhonghua Nei Ke Za Zhi 2020 Jun;59(6):464-467

Department of Cardiology, the First Affiliated Hospital of Soochow University, Suzhou 215006, China.

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http://dx.doi.org/10.3760/cma.j.cn112138-20190919-00639DOI Listing

The Role of Metabolic Changes in Shaping the Fate of Cancer-Associated Adipose Stem Cells.

Front Cell Dev Biol 2020 15;8:332. Epub 2020 May 15.

Endocrinology Unit, Department of Experimental and Clinical Biomedical Sciences "Mario Serio," University of Florence, Florence, Italy.

Adipose tissue in physiological and in metabolically altered conditions (obesity, diabetes, metabolic syndrome) strictly interacts with the developing tumors both systemically and locally. In addition to the cancer-associated fibroblasts, adipose cells have also recently been described among the pivotal actors of the tumor microenvironment responsible for sustaining tumor development and progression. In particular, emerging evidence suggests that not only the mature adipocytes but also the adipose stem cells (ASCs) are able to establish a strict crosstalk with the tumour cells, thus resulting in a reciprocal reprogramming of both the tumor and adipose components. Read More

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http://dx.doi.org/10.3389/fcell.2020.00332DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7242628PMC

First proof of association between autoimmune polyglandular syndrome and multiple endocrine neoplasia in humans.

Endocr J 2020 May 29. Epub 2020 May 29.

Department of Medicine (DIMED), Endocrinology Unit, Padua University, Padua, Italy.

Autoimmune Addison's disease (AAD) is a rare condition occurring either in isolation or associated with other autoimmune diseases as part of an autoimmune polyglandular syndrome (APS) type 1, 2 or 4. Multiple endocrine neoplasia (MEN) type 1, 2 or 4 is a hereditary autosomal dominant cancer syndrome. Medullary thyroid carcinoma and pheochromocytoma are neoplasms common to MEN-2a and MEN-2b. Read More

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http://dx.doi.org/10.1507/endocrj.EJ20-0099DOI Listing

Ancestry-specific predisposing germline variants in cancer.

Genome Med 2020 May 29;12(1):51. Epub 2020 May 29.

Department of Genetics and Genomics, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.

Background: Distinct prevalence of inherited genetic predisposition may partially explain the difference of cancer risks across ancestries. Ancestry-specific analyses of germline genomes are required to inform cancer genetic risk and prognosis of diverse populations.

Methods: We conducted analyses using germline and somatic sequencing data generated by The Cancer Genome Atlas. Read More

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http://dx.doi.org/10.1186/s13073-020-00744-3DOI Listing

Dexmedetomidine protects PC12 cells from ropivacaine injury through miR-381/LRRC4 /SDF-1/CXCR4 signaling pathway.

Regen Ther 2020 Jun 21;14:322-329. Epub 2020 May 21.

Department of Anesthesiology, Affiliated Shanghai Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai, 200233, PR China.

Introduction: Ropivacaine has been regularly used because of its good anesthetic and analgesic effects, but it may exert neurotoxic effects on neurocyte. Dexmedetomidine has presented special advantages in the fields of neuroprotection, and it also could improve peripheral nerve block combining with ropivacaine. However, if dexmedetomidine could repair neurocyte injury induced by ropivacaine, and the specific mechanism remain unclear. Read More

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http://dx.doi.org/10.1016/j.reth.2020.03.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243045PMC

Bladder paraganglioma mimicking a tumor contained in a ureterocele.

Urology 2020 May 24. Epub 2020 May 24.

Department of Urology, St. Vincent's Hospital, The Catholic University of Korea, Suwon, Korea. Electronic address:

Extra-adrenal pheochromocytoma is called paraganglioma. Paraganglioma near the ureterovesical junction can be confused with urothelial carcinoma in a ureterocele. Urinary metanephrine can be an indicator for bladder paraganglioma. Read More

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http://dx.doi.org/10.1016/j.urology.2020.05.026DOI Listing

Differential susceptibility of PC12 and BRL cells and the regulatory role of HIF-1α signaling pathway in response to acute methylmercury exposure under normoxia.

Toxicol Lett 2020 May 24. Epub 2020 May 24.

Department of Preventive Medicine and Public Health Laboratory Sciences, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu 212013, China; Center for Experimental Research, Kunshan Hospital Affiliated to Jiangsu University, Kunshan, Jiangsu 215130, China. Electronic address:

Hypoxia-inducible factor 1 (HIF-1) is a critical nuclear transcription factor for adaptation to hypoxia; its regulatable subunit, HIF-1α, is a cytoprotective regulatory factor. We examined the effects of methylmercury (MeHg) in rat adrenal pheochromocytoma (PC12) cells and the rat hepatocyte cell line BRL. MeHg treatment led to time- and concentration-dependent toxicity in both lines with statistically significant cytotoxic effects at 5 µM and 10 µM in PC12 and BRL, respectively, at 0. Read More

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http://dx.doi.org/10.1016/j.toxlet.2020.05.023DOI Listing

Identification of a novel SDHB c.563 T > C mutation responsible for Paraganglioma syndrome and genetic analysis of the SDHB gene in China: a case report.

BMC Med Genet 2020 May 27;21(1):116. Epub 2020 May 27.

Department of Cardiology, Tianjin Medical University General Hospital, Tianjin, 300070, China.

Background: Pheochromocytoma/paraganglioma (PPGL) is a rare neuroendocrine tumor. Succinate dehydrogenase (SDH) deficiency has been confirmed to be associated with PPGL in various studies. SDHB mutations play an important role in PPGL. Read More

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http://dx.doi.org/10.1186/s12881-020-01049-3DOI Listing

FDG Uptake in Brown Adipose Tissue Activated by a β3-Adrenergic Receptor Agonist Prescribed for Overactive Bladder.

Clin Nucl Med 2020 May 20. Epub 2020 May 20.

Diagnostic Radiology, Shiga General Hospital, Moriyama, Japan.

Brown adipose tissue (BAT), which produces energy and is known to play a role as a hibernating gland, is sometimes visualized on F-FDG PET in children or in slender young adults in a cold environment. Because BAT is activated by catecholamines, FDG uptake in BAT is also observed in patients with pheochromocytoma or paraganglioma. We present the case of an elderly woman with remarkable FDG uptake in BAT. Read More

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http://dx.doi.org/10.1097/RLU.0000000000003078DOI Listing

[A case of giant pheochromocytoma presenting as acute left sided heart failure].

Authors:
Y Long Y Li X Li

Zhonghua Xin Xue Guan Bing Za Zhi 2020 May;48(5):420-422

Department of Cardiology, Chongqing Traditional Chinese Medicine Hospital, Chongqing 400021, China.

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http://dx.doi.org/10.3760/cma.j.cn112148-20190625-00356DOI Listing

Management of adrenal incidentalomas: Working through uncertainty.

Best Pract Res Clin Endocrinol Metab 2020 May 15:101427. Epub 2020 May 15.

Department of Endocrinology, Diabetes and Nutrition, University Hospital of Bordeaux, 33604 Pessac, France; Inserm U1215, Neurocentre Magendie, University of Bordeaux, 146 Rue Leo Saignat, 33076 Bordeaux Cedex, France. Electronic address:

The European society of endocrinology, in association with the European network for the study of adrenal tumors, published recommendations for the diagnosis and treatment of adrenal incidentalomas in 2016. A thorough and critical analysis of the literature was performed to establish evidence-based recommendations and expert suggestions with the aim of avoiding 'over-diagnosis' and 'over-treatment' and to reduce unnecessary investigations, surgery and follow-up. The purpose of this review is to reconsider several recommendations that are open to debate, such as imaging of adrenal incidentalomas, diagnosis of pheochromocytoma, diagnosis and treatment of autonomous cortisol-secreting tumors, investigations of bilateral AI and follow-up of non-operated AIs, based on studies published after the release of the recommendations. Read More

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http://dx.doi.org/10.1016/j.beem.2020.101427DOI Listing

An update of posterior retroperitoneoscopic adrenalectomy - Case series.

Int J Surg Case Rep 2020 May 16;71:120-125. Epub 2020 May 16.

General Surgery, Centro Hospitalar e Universitário de Coimbra (Hospital Geral - Covões), Quinta dos vales, São Martinho do Bispo, 3041-853 Coimbra, Portugal. Electronic address:

Introduction: Posterior retroperitoneoscopic adrenalectomy (PRA) has advantages over transperitoneal approach. A second group of 10 patients is analyzed and compared with the first 10 procedures. Conclusions on feasibility, safety and learning curve are taken. Read More

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http://dx.doi.org/10.1016/j.ijscr.2020.04.101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7256207PMC

Diagnosis and treatment of a diaphragmatic pheochromocytoma: A case report.

Int J Surg Case Rep 2020 May 7;71:78-81. Epub 2020 May 7.

Department of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and PUMC, Beijing, China.

Background: Ectopic pheochromocytomas, the incidence of which is >15%, can occur throughout the entire body but seldom on the diaphragm. Surgery may the first-choice treatment for ectopic pheochromocytomas.

Presentation Of Case: We herein describe a 61-year-old woman with an atopic diaphragmatic pheochromocytoma. Read More

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http://dx.doi.org/10.1016/j.ijscr.2020.04.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7242994PMC

Enhanced Nerve Cell Proliferation and Differentiation on Electrically Conductive Scaffolds Embedded with Graphene and Carbon Nanotubes.

J Biomed Mater Res A 2020 May 22. Epub 2020 May 22.

Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States.

Conduits that promote nerve regeneration are currently of great medical concern, particularly when gaps exist between nerve endings. To address this issue, our laboratory previously developed a nerve conduit from biodegradable poly(caprolactone fumarate) (PCLF) that supports peripheral nerve regeneration. The present study improves upon this work by further developing an electrically conductive, positively charged PCLF scaffold through the incorporation of graphene, carbon nanotubes (CNTs), and [2-(methacryloyloxy)ethyl]trimethylammonium chloride (MTAC) (PCLF-Graphene-CNT-MTAC ) using ultraviolet (UV) induced photo-crosslinking. Read More

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http://dx.doi.org/10.1002/jbm.a.37016DOI Listing

Stemness regulation of the adrenal mixed corticomedullary tumorigenesis-a case-control study.

Neoplasia 2020 Jul 18;22(7):263-271. Epub 2020 May 18.

Division of Endocrinology and Metabolism, Department of Internal Medicine, School of Medicine, College of Medicine, Kaohsiung Medical University, Taiwan. Electronic address:

Mixed corticomedullary tumor is an adrenal tumor intermixed with cortical and medullary cells. It is extremely rare with unclear tumorigenesis. We reported a 32-year-old female, manifested with typical Cushing's syndrome and hypertension, to be diagnosed with right huge adrenal mixed corticomedullary tumor (8. Read More

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http://dx.doi.org/10.1016/j.neo.2020.04.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240194PMC

Bladder preservation for patients with bladder paragangliomas: case series and review of the literature.

Urology 2020 May 10. Epub 2020 May 10.

Department of Urology, NewYork-Presbyterian Hospital, Columbia University Irving Medical Center, New York, NY.

Bladder paragangliomas are rare tumors, with no prospective studies or guidelines on the management of this disease. We present a case series of six patients managed with bladder preservation over a median follow-up period of 124 months. We also present a review of the recent literature on bladder paragangliomas. Read More

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http://dx.doi.org/10.1016/j.urology.2020.04.098DOI Listing

Robotic Adrenalectomy for Pheochromocytoma in a Patient with Fontan Physiology.

J Cardiothorac Vasc Anesth 2020 Mar 5. Epub 2020 Mar 5.

Department of Surgery, Vanderbilt University Medical Center, Nashville, TN. Electronic address:

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http://dx.doi.org/10.1053/j.jvca.2020.02.050DOI Listing

Adrenalectomy during pregnancy: A 15-year experience at a tertiary referral center.

Surgery 2020 May 17. Epub 2020 May 17.

Department of Digestive, Hepato-biliary and Endocrine Surgery, Referral Center for Rare Adrenal Diseases, Cochin Hospital, APHP, Paris, France; Faculté de Médecine Paris Descartes, Université Paris Descartes, Sorbonne Paris Cité, France; INSERM Unité 1016, Centre National de la Recherche Scientifique Unité Mixte de Recherche 8104, Institut Cochin, Paris, France.

Background: Adrenal lesions diagnosed during pregnancy remain rare, and their management is challenging because of maternal physiologic modifications, restricted imaging investigations, and contraindications to several treatments. Surgical issues of adrenalectomy during pregnancy and consequences on perinatal outcomes are poorly described. We therefore aimed to report maternal and fetal outcomes after adrenalectomy during pregnancy. Read More

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http://dx.doi.org/10.1016/j.surg.2020.03.019DOI Listing

Pheochromocytoma and Paraganglioma in Children and Adolescents: Experience of the French Society of Pediatric Oncology (SFCE).

J Endocr Soc 2020 May 3;4(5):bvaa039. Epub 2020 Apr 3.

Centre de Cancérologie Gustave Roussy, Département de Cancérologie de l'Enfant et de l'Adolescent, Paris-Saclay University Villejuif, France.

Purpose: The purpose of this work is to assess the clinical outcome of pediatric patients diagnosed with pheochromocytoma and paraganglioma (PPGL) detected in France since 2000.

Methods: A retrospective multicenter study was conducted that included all patients younger than 18 years with PPGL diagnosed in France between 2000 and 2016. Patients were identified from 4 different sources: the National Registry of Childhood Solid Tumors, the French Pediatric Rare Tumors Database, the French registry of succinate dehydrogenase (SDH)-related hereditary paraganglioma, and the nationwide TenGen network. Read More

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http://dx.doi.org/10.1210/jendso/bvaa039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7217277PMC

From ACTH-Dependent to ACTH-Independent Cushing's Syndrome from a Malignant Mixed Corticomedullary Adrenal Tumor: Potential Role of Embryonic Stem Cells.

Case Rep Endocrinol 2020 4;2020:4768281. Epub 2020 May 4.

Endocrinology Service, UIM Enfermedades Endocrinas, Hospital de Especialidades, Centro Médico Nacional, S.XXI, Instituto Mexicano del Seguro Social, Av Cuauhtemoc 330, Col. Doctores, CP 06720, Mexico City, Mexico.

Objective: To report the immunohistochemical and molecular evaluation of a patient with ectopic ACTH syndrome (EAS) from a MCAT which has single cells with features of both 96 medullary and cortical differentiation. . A 16-year-old woman presented with severe EAS and a large right MCAT composed of ACTH-secreting cells resembling pheochromocytoma and another lineage similar to adrenal carcinoma. Read More

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http://dx.doi.org/10.1155/2020/4768281DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218959PMC

Hernia after retroperitoneoscopic adrenalectomy, case report.

Gland Surg 2020 Apr;9(2):442-446

Resident in Surgery, Klinik für Viszeralchirurgie, Kantonsspital Aarau, Aarau, Switzerland.

We report the first case of a previously undocumented complication after posterior retroperitoneal adrenalectomy (PRA). Extensive diagnostic procedures for persisting abdominal pain led to diagnosis of an incisional hernia (IH) approximately 2.5 years after surgery for a pheochromocytoma of the right adrenal gland. Read More

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http://dx.doi.org/10.21037/gs.2020.01.03DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225460PMC

Not all adrenal incidentalomas require biochemical testing to exclude pheochromocytoma: Mayo clinic experience and a meta-analysis.

Gland Surg 2020 Apr;9(2):362-371

Department of Surgery, Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, MN, USA.

Background: Excluding a pheochromocytoma is important when a patient presents with an incidentally discovered adrenal mass. However, biochemical testing for pheochromocytoma can be cumbersome, time consuming, or falsely positive. Our objective was to determine if unenhanced computed tomography (CT) imaging alone can be used to rule out pheochromocytoma. Read More

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http://dx.doi.org/10.21037/gs.2020.03.04DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225448PMC

AQP2 as a diagnostic immunohistochemical marker for pheochromocytoma and/or paraganglioma.

Gland Surg 2020 Apr;9(2):200-208

Department of Pathology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital & Institute, Beijing 100142, China.

Background: Aquaporin2 (AQP2) is water channel protein that is widely distributed among mammalian tissues and plays a major role in water homeostasis. However, little is known about the expression and significance of AQP2 in human adrenal tumors. Thus, we performed an immunohistochemical investigation of AQP2 in normal and neoplastic adrenal tissues. Read More

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http://dx.doi.org/10.21037/gs.2020.01.19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225480PMC

Clinical and genetic features of pediatric PCCs/PGLs patients: a single-center experience in China.

Transl Androl Urol 2020 Apr;9(2):267-275

Department of Urology, Xiangya Hospital, Central South University, Changsha 410008, China.

Background: Although 40% to 80% of pediatric patients with pheochromocytoma (PCC) and paraganglioma (PGL) have been reported to carry germline mutations, the genetic and clinical features are poorly understood, and few such patients have undergone genetic testing. In this series, we aimed to investigate the clinical and genetic features of Han Chinese pediatric patients with PCC/PGL.

Methods: The medical records of 15 pediatric patients with PCC/PGL who presented to our hospital between 2006 and 2018 were retrospectively studied. Read More

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http://dx.doi.org/10.21037/tau.2020.02.14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214975PMC

Spontaneous hemorrhage of an adrenal myelolipoma treated with transarterial embolization: A case report.

Radiol Case Rep 2020 Jul 7;15(7):961-965. Epub 2020 May 7.

Department of Radiology, Section of Vascular and Interventional Radiology, University of Missouri, One Hospital Drive, Columbia, MO 65212, USA.

Adrenal myelolipoma is a benign tumor of the adrenal cortex composed predominantly of fat and hematopoietic tissue. These lesions are usually asymptomatic, and most often incidentally detected on imaging. Uncommonly, they present with retroperitoneal hemorrhage, and these have been traditionally treated with emergent surgery. Read More

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http://dx.doi.org/10.1016/j.radcr.2020.04.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214766PMC

Prevalence and Incidence of Atrial Fibrillation in a Large Cohort of Adrenal Incidentalomas: A Long-Term Study.

J Clin Endocrinol Metab 2020 May 15. Epub 2020 May 15.

Endocrinology and Diabetes Prevention and Care Unit, Department of Medical and Surgical Sciences, University Alma Mater Studiorum of Bologna, S. Orsola-Malpighi Hospital, Bologna, Italy.

Context: Chronic glucocorticoids excess leads to morphological and functional cardiac alterations, a substrate for arrhythmias. Autonomous cortisol secretion (ACS) in adrenal incidentalomas is a model of chronic endogenous hypercortisolism.

Objective: To investigate prevalence and incidence of atrial fibrillation (AF) in a large cohort of patients with ACS. Read More

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http://dx.doi.org/10.1210/clinem/dgaa270DOI Listing

Genetics, diagnosis, management and future directions of research of phaeochromocytoma and paraganglioma: a position statement and consensus of the Working Group on endocrine hypertension of the European society of hypertension.

J Hypertens 2020 May 13. Epub 2020 May 13.

Department of Medicine III, University Hospital Carl Gustav Carus, Technical University Dresden, Dresden, Germany.

: Phaeochromocytoma and paraganglioma (PPGL) are chromaffin cell tumours that require timely diagnosis because of their potentially serious cardiovascular and sometimes life- threatening sequelae. Tremendous progress in biochemical testing, imaging, genetics and pathophysiological understanding of the tumours has far-reaching implications for physicians dealing with hypertension and more importantly affected patients. Because hypertension is a classical clinical clue for PPGL, physicians involved in hypertension care are those who are often the first to consider this diagnosis. Read More

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http://dx.doi.org/10.1097/HJH.0000000000002438DOI Listing

Bilateral pheochromocytoma: Clinical characteristics, treatment, and longitudinal follow-up.

Clin Endocrinol (Oxf) 2020 May 14. Epub 2020 May 14.

Division of Endocrinology, Diabetes, and Nutrition, Mayo Clinic, Rochester, MN, USA.

Objective: Comprehensive data about patients with bilateral pheochromocytoma is limited. We aimed to describe the clinical presentation, genetic analysis, treatment, and outcomes of patients with bilateral pheochromocytoma.

Design: A retrospective study at a tertiary care center PATIENTS: All patients with bilateral pheochromocytoma evaluated at Mayo Clinic in Rochester, Minnesota between January 1951 and December 2015. Read More

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http://dx.doi.org/10.1111/cen.14222DOI Listing

Safety of outpatient adrenalectomy across 3 minimally invasive approaches at 2 academic medical centers.

Surgery 2020 May 11. Epub 2020 May 11.

Department of Surgery, University of Alabama at Birmingham, AL.

Background: Outpatient adrenalectomy has the potential to decrease costs, improve inpatient capacity, and decrease patient exposure to hospital-acquired conditions. Still, the practice has yet to be widely adopted and current studies demonstrating the safety of outpatient adrenalectomy are limited by sample size, extensive exclusion criteria, and no comparison to inpatient cases. We aimed to study the characteristics and safety of outpatient adrenalectomy using the largest such sample to date across 2 academic medical centers and 3 minimally invasive approaches. Read More

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http://dx.doi.org/10.1016/j.surg.2020.03.026DOI Listing

Hemodynamic volatility that can result from suboptimal preoperative optimization complicated by Fontan physiology during a pheochromocytoma removal.

J Clin Anesth 2020 May 11;65:109828. Epub 2020 May 11.

Valley Anesthesiology and Pain Consultants - Envision Physician Services, Phoenix, AZ, United States of America; University of Arizona College of Medicine - Phoenix, Department of Anesthesiology, Phoenix, AZ, United States of America; Creighton University School of Medicine, Department of Anesthesiology, Omaha, NE, United States of America.

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http://dx.doi.org/10.1016/j.jclinane.2020.109828DOI Listing

Dataset for the Reporting of Pheochromocytoma and Paraganglioma: Explanations and Recommendations of the Guidelines from the International Collaboration on Cancer Reporting (ICCR).

Hum Pathol 2020 May 11. Epub 2020 May 11.

Department of Pathology and Laboratory Medicine, Tufts Medical Center, Boston,USA. Electronic address:

Background And Objectives: The International Collaboration on Cancer Reporting (ICCR) is a not-for-profit organized to develop evidence-based, internationally agreed upon standardized datasets for each anatomic site, to be used throughout the world. Providing global standardization of pathology tumor classification, staging, and other reporting elements will lead to improved patient management and enhanced epidemiological research.

Methods: Pheochromocytoma and paraganglioma are uncommon and are frequently overlooked in registry datasets. Read More

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http://dx.doi.org/10.1016/j.humpath.2020.04.012DOI Listing

True Picomolar Neurotransmitter Sensor Based on Open-Ended Carbon Nanotubes.

Anal Chem 2020 Jun 1. Epub 2020 Jun 1.

Department of Chemistry, University of Cincinnati, Cincinnati, Ohio 45221, United States.

Neurotransmitters are important chemicals in human physiological systems for initiating neuronal signaling pathways and in various critical health illnesses. However, concentration of neurotransmitters in the human body is very low (nM or pM level) and it is extremely difficult to detect the fluctuation of their concentrations in patients using existing electrochemical biosensors. In this work, we report the performance of highly densified carbon nanotubes fiber (HD-CNT) cross-sections called rods (diameter ∼ 69 μm, and length ∼ 40 μm) as an ultrasensitive platform for detection of common neurotransmitters. Read More

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http://dx.doi.org/10.1021/acs.analchem.0c01363DOI Listing

Extracorporeal life support for phaeochromocytoma-induced cardiogenic shock: a systematic review.

Perfusion 2020 May;35(1_suppl):20-28

Department of Cardiothoracic Surgery, Heart and Vascular Centre, Maastricht University Medical Centre (MUMC), Maastricht, The Netherlands.

Introduction: Phaeochromocytoma is a catecholamine-secreting tumour associated with clinical presentation ranging from paroxysmal hypertension to intractable cardiogenic shock. Extracorporeal life support, in veno-arterial mode, application in refractory acute heart dysfunction is sharply increasing worldwide. However, its clinical utility in phaeochromocytoma-induced cardiogenic shock remains still unclear. Read More

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http://dx.doi.org/10.1177/0267659120908413DOI Listing

Veno-arterial extracorporeal membrane oxygenation for pheochromocytoma-related shock: treat cause and consequence.

Perfusion 2020 May;35(1_suppl):18-19

2nd Department of Medicine - Department of Cardiovascular Medicine, First Faculty of Medicine, Charles University and General University Hospital in Prague, U Nemocnice 2, 128 08, Praha 2, Czech Republic.

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http://dx.doi.org/10.1177/0267659120909770DOI Listing

Molecular imaging of norepinephrine transporter-expressing tumors: current status and future prospects.

Q J Nucl Med Mol Imaging 2020 May 12. Epub 2020 May 12.

Nuclear Medicine, University Hospitals Leuven, Leuven, Belgium -

The human norepinephrine transporter (hNET) is a transmembrane protein responsible for reuptake of norepinephrine in presynaptic sympathetic nerve terminals and adrenal chromaffin cells. Neural crest tumors, such as neuroblastoma, paraganglioma and pheochromocytoma often show high hNET expression. Molecular imaging of these tumors can be done using radiolabeled norepinephrine analogs that target hNET. Read More

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http://dx.doi.org/10.23736/S1824-4785.20.03261-6DOI Listing

Cadmium induces mitophagy via AMP-activated protein kinases activation in a PINK1/Parkin-dependent manner in PC12 cells.

Cell Prolif 2020 May 12:e12817. Epub 2020 May 12.

College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu, China.

Objectives: Cadmium (Cd) induces mitophagy in neuronal cells, but the underlying mechanisms remain unknown. In this study, we aimed to investigate these mechanisms.

Materials And Methods: The effects of Cd on the mitophagy in rat pheochromocytoma PC12 cells were detected, and the role of PINK1/Parkin pathway in Cd-induced mitophagy was also analysed by using PINK1 siRNA. Read More

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http://dx.doi.org/10.1111/cpr.12817DOI Listing

Knocking down TRPM2 expression reduces cell injury and NLRP3 inflammasome activation in PC12 cells subjected to oxygen-glucose deprivation.

Neural Regen Res 2020 Nov;15(11):2154-2161

Department of Neonatology, Children's Hospital Affiliated to Suzhou University, Suzhou, Jiangsu Province, China.

Transient receptor potential melastatin 2 (TRPM2) is an important ion channel that represents a potential target for treating injury caused by cerebral ischemia. However, it is unclear whether reducing TRPM2 expression can help repair cerebral injury, and if so what the mechanism underlying this process involves. This study investigated the protective effect of reducing TRPM2 expression on pheochromocytoma (PC12) cells injured by oxygen-glucose deprivation (OGD). Read More

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http://dx.doi.org/10.4103/1673-5374.282271DOI Listing
November 2020

Spinal paraganglioma as unusual finding in von Hippel-Lindau disease.

J Clin Neurosci 2020 May 7. Epub 2020 May 7.

Department of Neurosurgery, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany.

A 20-year-old patient with a history of von Hippel-Lindau disease reported on thoracic back pain radiating to the left shoulder for 10 weeks. Magnetic resonance imaging revealed a progressive contrast-enhancing tumor (14 × 21 × 28 mm) compressing the spinal cord and extending into the left neural foramen at T5/6. After embolization of supplying vessels, the tumor was completely resected via hemilaminectomy of T5. Read More

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http://dx.doi.org/10.1016/j.jocn.2020.05.025DOI Listing

MEN2-related pheochromocytoma: current state of knowledge, specific characteristics in MEN2B, and perspectives.

Endocrine 2020 May 10. Epub 2020 May 10.

Department of Endocrinology, Aix-Marseille University, INSERM U1251, Endo-ERN Reference Center for Rare Genetic Tumor Syndromes, Assistance Publique-Hopitaux de Marseille, Marseille, France.

Multiple endocrine neoplasia type 2 (MEN2) is a rare hereditary syndrome due to mutations of the proto-oncogene REarranged during Transfection (RET), defined by the association of medullary thyroid carcinoma (MTC) in almost 100% cases, and pheochromocytoma in roughly 50% (primary hyperparathyroidism can be seen in 10-20% of patients with MEN2A). Early thyroidectomy and the efficacy of novel tyrosine kinase inhibitors modified the natural history of MTC, with possibilities of cure or long-term control. The second main compound, pheochromocytoma, is reported with a variable penetrance, from 10 to 80% cases, depending on the mutation of RET. Read More

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http://dx.doi.org/10.1007/s12020-020-02332-2DOI Listing