22,968 results match your criteria Pheochromocytoma


[Pheochromocytomas and paragangliomas in pregnancy: about four cases and key messages on management].

Gynecol Obstet Fertil Senol 2021 May 4. Epub 2021 May 4.

CHU Lille, Clinique d'obstétrique, Univ. Lille, EA 2694 Metrics, Environnement périnatal et santé, F-59000 - Hôpital Jeanne de Flandre, avenue Eugène Avinée, 59000 Lille, France.

Objectifs: The diagnosis of a pheochromocytoma or paraganglioma secreting during pregnancy is a rare and serious situation, involving maternal-fetal prognosis. The purpose of this case series is to discuss the management of these patients.

Methods: This is a retrospective study of cases of pheochromocytoma (n=2) or paraganglioma (n=2) managed during pregnancy between 2013 and 2020 in one center (Lille, France). Read More

View Article and Full-Text PDF

Formulation and Characterization of Microcapsules Encapsulating PC12 Cells as a Prospective Treatment Approach for Parkinson's Disease.

AAPS PharmSciTech 2021 May 7;22(4):149. Epub 2021 May 7.

Center for Drug Delivery Research, Vaccine Nanotechnology Laboratory, Mercer University College of Pharmacy, Atlanta, Georgia, 30341, USA.

Parkinson's disease (PD) is the second most common neurological disorder, associated with decreased dopamine levels in the brain. The goal of this study was to assess the potential of a regenerative medicine-based cell therapy approach to increase dopamine levels. In this study, we used rat adrenal pheochromocytoma (PC12) cells that can produce, store, and secrete dopamine. Read More

View Article and Full-Text PDF

Pheochromocytoma and Paraganglioma in Pregnancy: a New Era.

Curr Cardiol Rep 2021 May 7;23(6):60. Epub 2021 May 7.

Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Mayo Clinic, 200 First St. SW, Rochester, MN, 55905, USA.

Purpose Of Review: Pheochromocytoma and paraganglioma (PPGL) in pregnancy is a rare entity and management of these patients is fraught with uncertainty. Our objective is to review current literature and discuss diagnosis and management of these patients.

Recent Findings: Outcomes of PPGL in pregnancy have improved in recent years. Read More

View Article and Full-Text PDF

Autoresuscitation and pheochromocytoma multisystem crisis in a dog.

J Vet Emerg Crit Care (San Antonio) 2021 May 7. Epub 2021 May 7.

Emergency and Critical Care, VCA West Coast Specialty and Emergency Animal Hospital, Fountain Valley, California, USA.

Objective: To describe the clinical course of a dog with a pheochromocytoma multisystem crisis that exhibited autoresuscitation after cardiac arrest.

Case Summary: An approximately 10-year-old male neutered terrier mix dog presented for collapse. Abdominal imaging was suggestive of a pheochromocytoma, and clinical pathology data and thoracic imaging suggested the presence of a multisystem crisis. Read More

View Article and Full-Text PDF

Multidisciplinary practice guidelines for the diagnosis, genetic counseling and treatment of pheochromocytomas and paragangliomas.

Clin Transl Oncol 2021 May 6. Epub 2021 May 6.

Endocrinology and Nutrition Department, Hospital Clinic Barcelona, University of Barcelona, IDIBAPS, Barcelona, Spain.

Pheochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine tumors that arise from chromaffin cells of the adrenal medulla and the sympathetic/parasympathetic neural ganglia, respectively. The heterogeneity in its etiology makes PPGL diagnosis and treatment very complex. The aim of this article was to provide practical clinical guidelines for the diagnosis and treatment of PPGLs from a multidisciplinary perspective, with the involvement of the Spanish Societies of Endocrinology and Nutrition (SEEN), Medical Oncology (SEOM), Medical Radiology (SERAM), Nuclear Medicine and Molecular Imaging (SEMNIM), Otorhinolaryngology (SEORL), Pathology (SEAP), Radiation Oncology (SEOR), Surgery (AEC) and the Spanish National Cancer Research Center (CNIO). Read More

View Article and Full-Text PDF

Outcomes of malignant pheochromocytoma based on operative approach: A National Cancer Database analysis.

Surgery 2021 May 3. Epub 2021 May 3.

Department of Surgery, University Hospitals Cleveland Medical Center, OH. Electronic address:

Background: Malignant pheochromocytoma is often managed with adrenalectomy. Most literature focusing on postoperative outcomes are from single institutions. This study aimed to describe outcomes of adrenalectomy for malignant pheochromocytoma using a national database. Read More

View Article and Full-Text PDF

Pheochromocytoma Presenting as Testicular Pain: An Unusual Case Report.

Case Rep Endocrinol 2021 14;2021:6699409. Epub 2021 Apr 14.

Department of Internal Medicine, HCA Healthcare/USF Morsani College of Medicine GME: Medical Center of Trinity, Trinity, FL, USA.

Pheochromocytoma (PCC) is a rare catecholamine-secreting tumor that arises from chromaffin cells of the adrenal medulla which are derived from the neural crest. This report illustrates a 51-year-old Caucasian male with a history of hypertension diagnosed two years ago who presented to the hospital due to acute onset of right testicular pain of 3-day duration. Laboratory results and imaging revealed a presumptive diagnosis of PCC. Read More

View Article and Full-Text PDF

En kvinne i 50-årene med magesmerter og alvorlig laktacidose.

Tidsskr Nor Laegeforen 2021 Apr 27. Epub 2021 Apr 27.

Background: Pheochromocytoma is referred to as 'the great mimic' with a broad spectrum of presenting symptoms. In the following case, the diagnosis had an unusual presentation as a medical emergency - pheochromocytoma crisis.

Case Presentation: A previously healthy woman in her fifties was admitted due to abdominal pain and dyspnoea. Read More

View Article and Full-Text PDF

GIPC2 is an endocrine-specific tumor suppressor gene for both sporadic and hereditary tumors of RET- and SDHB-, but not VHL-associated clusters of pheochromocytoma/paraganglioma.

Cell Death Dis 2021 May 4;12(5):444. Epub 2021 May 4.

Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical College, Beijing, China.

Pheochromocytoma/paraganglioma (PPGL) is an endocrine tumor of the chromaffin cells in the adrenal medulla or the paraganglia. Currently, about 70% of PPGLs can be explained by germline or somatic mutations in several broadly expressed susceptibility genes including RET, VHL, and SDHB, while for the remaining, mainly sporadic cases, the pathogenesis is still unclear. Even for known susceptible genes, how mutations in these mostly ubiquitous genes result in tissue-specific pathogenesis remains unanswered, and why RET-mutated tumors almost always occur in the adrenal while SDHB-mutated tumors mostly occur extra-adrenal remains a mystery. Read More

View Article and Full-Text PDF

[Bladder paraganglioma: Report of two cases and a literature review.]

Arch Esp Urol 2021 May;74(4):445-449

Servicio de Oncología Médica. Hospital General Universitario de Elche. España. Unidad de Consejo Genético. Hospital General Universitario de Elche. España.

Objective: Description of two incidental cases of bladder paraganglioma in women and review of the published literature.

Methods: A bibliographic search was carried out in Medline over the last 10 years according to the terms "urinary bladder" and "paraganglioma".

Results: Bladder paraganglioma (BP) accounts for less than 0. Read More

View Article and Full-Text PDF

The North American Neuroendocrine Tumor Society Consensus Guidelines for Surveillance and Management of Metastatic and/or Unresectable Pheochromocytoma and Paraganglioma.

Pancreas 2021 Apr;50(4):469-493

Department of Endocrine Neoplasia and Hormonal Disorders, The University of Texas MD Anderson Cancer Center, Houston, TX.

Abstract: This manuscript is the result of the North American Neuroendocrine Tumor Society consensus conference on the medical management and surveillance of metastatic and unresectable pheochromocytoma and paraganglioma held on October 2 and 3, 2019. The panelists consisted of endocrinologists, medical oncologists, surgeons, radiologists/nuclear medicine physicians, nephrologists, pathologists, and radiation oncologists. The panelists performed a literature review on a series of questions regarding the medical management of metastatic and unresectable pheochromocytoma and paraganglioma as well as questions regarding surveillance after resection. Read More

View Article and Full-Text PDF

Retroperitoneal liposarcoma mimicking pheochromocytoma.

Radiol Case Rep 2021 Jun 15;16(6):1493-1498. Epub 2021 Apr 15.

Department of Clinical Surgical Sciences, The University of the West Indies, St Augustine Campus, Trinidad, West Indies.

Retroperitoneal liposarcomas are rare mesenchymal tumors which carry a poor prognosis because of their late presentation. When symptoms do occur, they are usually nonspecific and related to mass effect or invasion of local structures. Rarely, retroperitoneal liposarcomas can clinically and biochemically mimic phaeochromocytomas. Read More

View Article and Full-Text PDF

Endocrine emergencies in anesthesia.

Curr Opin Anaesthesiol 2021 Jun;34(3):326-334

Yale University School of Medicine, New Haven, Connecticut, USA.

Purpose Of Review: An increasing number of patients with endocrine disorders will present to the operating rooms. In this review, we outline the common endocrine disorders that the anesthesiologist may face in the perioperative time span, review the controversies in optimal management, as well as summarize the recent literature for the management of these complex patients.

Recent Findings: Perioperative management of pheochromocytoma and paraganglioma has been facilitated by improved medical management and the adoption of minimally invasive surgical techniques. Read More

View Article and Full-Text PDF

Multiple Distal Saccular Coronary Aneurysms Associated With Pheochromocytoma.

JACC Cardiovasc Interv 2021 Apr 21. Epub 2021 Apr 21.

Department of Cardiology, Hôpital de l'Hôtel-Dieu de Québec, Quebec City, Quebec, Canada.

View Article and Full-Text PDF

Clinical Perspectives of Theranostics.

Molecules 2021 Apr 13;26(8). Epub 2021 Apr 13.

Department of Radiology, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan.

Theranostics is a precision medicine which integrates diagnostic nuclear medicine and radionuclide therapy for various cancers throughout body using suitable tracers and treatment that target specific biological pathways or receptors. This review covers traditional theranostics for thyroid cancer and pheochromocytoma with radioiodine compounds. In addition, recent theranostics of radioimmunotherapy for non-Hodgkin lymphoma, and treatment of bone metastasis using bone seeking radiopharmaceuticals are described. Read More

View Article and Full-Text PDF

Neuroprotective Effects of Curcumin in Methamphetamine-Induced Toxicity.

Molecules 2021 Apr 24;26(9). Epub 2021 Apr 24.

Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Via Roma 55, 56126 Pisa, Italy.

Curcumin (CUR), a natural polyphenol extracted from rhizome of the , has received great attention for its multiple potential health benefits as well as disease prevention. For instance, CUR protects against toxic agents acting on the human body, including the nervous system. In detail, CUR possesses, among others, strong effects as an autophagy activator. Read More

View Article and Full-Text PDF

Rare presentation of collapse and cardiomyopathy in phaeochromocytoma.

Endocrinol Diabetes Metab Case Rep 2021 Apr 1;2021. Epub 2021 Apr 1.

Department of Diabetes and EndocrinologyDarent Valley Hospital, Dartford, UK.

Summary: A phaeochromocytoma is a rare neuroendocrine tumour derived from the chromaffin cells of the adrenal medulla. Tumours can produce excessive amounts of catecholamines. The presenting symptoms can vary but often include the classic triad of episodic headaches, sweating and palpitations. Read More

View Article and Full-Text PDF

Stress cardiomyopathy: Medical studies and extensive review.

Saudi J Biol Sci 2021 Apr 14;28(4):2598-2601. Epub 2021 Feb 14.

Department of Cardiology, Jinan People's Hospital Affiliated to Shandong First Medical University, Jinan, Shandong 271199, China.

Stress cardiomyopathy (SC) was first reported in the year 1983. It is narrated as critical but quite commutative left ventricular (LV) malfunction mostly caused by poignant or psychological disorder. Numerous variations of SC have been described as well as reverse stress cardiomyopathy (rSC) which is an adaptation identified by the decreased muscle movement related with hyperkinesis that reconciles impetuously. Read More

View Article and Full-Text PDF

Multimodality Imaging Review of Multiple Endocrine Neoplasia.

AJR Am J Roentgenol 2021 Apr 28:1-12. Epub 2021 Apr 28.

Department of Radiology and Imaging Sciences, University of Utah, Salt Lake City, UT.

The purpose of this article is to review the clinical manifestations, endocrine tumors types, and multimodality diagnostic tools available to physicians involved in the management of patients with multiple endocrine neoplasia (MEN) syndrome, in addition to discussing relevant imaging findings and appropriate imaging follow-up. Thorough knowledge of the spectrum of tumors associated with gene mutations aids in the screening, diagnostic workup, and posttreatment monitoring of patients with MEN-related gene mutations. Read More

View Article and Full-Text PDF

Comparison of Outcomes between Obese and Nonobese Patients in Laparoscopic Adrenalectomy: A Cohort Study.

Dig Surg 2021 Apr 27:1-10. Epub 2021 Apr 27.

Department of Surgery, Department of Medical Sciences, Dr. Josep Trueta University Hospital, Girona Biomedical Research Institute (IDIBGI), Faculty of Medicine, University of Girona, Girona, Spain.

Introduction: Obesity is usually considered a risk factor for surgical complications. Laparoscopic adrenalectomy has replaced open adrenalectomy as the standard operation for adrenal tumors.

Objective: To compare the safety of laparoscopic adrenalectomy to treat adrenal tumors in obese versus nonobese patients. Read More

View Article and Full-Text PDF

Adrenal cavernous hemangioma misdiagnosed as pheochromocytoma: a case report.

BMC Surg 2021 Apr 26;21(1):210. Epub 2021 Apr 26.

Department of Urology, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, 321000, China.

Background: Adrenal hemangioma is a rare benign adrenal tumor that is usually misdiagnosed preoperatively. We here present a case of adrenal cavernous hemangioma that was successfully treated with retroperitoneal laparoscopic adrenalectomy.

Case Presentation: A 67-year-old man with dull right back pain attended our clinic for examination of a mass on the right adrenal gland for 1 week. Read More

View Article and Full-Text PDF

[PSEUDOPHEOCHROMOCYTOMA - AN UNCOMMON FORM OF HYPERTENSION].

Harefuah 2021 Apr;160(4):245-249

Hypertension Unit, Sheba Medical Center, Tel Hashomer and Sackler Faculty of Medicine, Tel Aviv University, Israel.

Introduction: Pseudopheochromocytoma is an uncommon form of hypertension. In contrast to the more well-known pheochromocytoma, no unequivocal etiologic factor or a clear physiological abnormality can be identified. This disorder manifests in sudden, recurrent, episodes of significant, sometimes extreme, increase in blood pressure, both systolic and diastolic, lasting from minutes to hours, with no consistent trigger that the patient or the doctor is aware of, and is accompanied by typical symptoms. Read More

View Article and Full-Text PDF

Leptin Induces Epigenetic Regulation of Transient Receptor Potential Melastatin 7 in PC12 Cells.

Am J Respir Cell Mol Biol 2021 Apr 23. Epub 2021 Apr 23.

University of Pittsburgh Graduate School of Public Health, 51303, Environmental and Occupational Health, Pittsburgh, Pennsylvania, United States;

Obesity elevates plasma level of leptin, which has been associated with hypertension. Our recent studies in mice demonstrated that leptin increases blood pressure by activating the carotid sinus nerve, which transmits the chemosensory input from carotid bodies (CB) to the medullary centers; and the effect of leptin is mediated via transient receptor potential melastatin 7 (Trpm7) channels in CB glomus cells. We also found that Trpm7 overexpression and Trpm7 promoter demethylation in CB correlate positively with the hyperleptinemia and leptin receptor overexpression in CB. Read More

View Article and Full-Text PDF

Vasoactive intestinal peptide producing pheochromocytoma and intracardiac thrombosis.

Rare Tumors 2021 9;13:20363613211007792. Epub 2021 Apr 9.

Cardiology, Scripps Health, San Diego, CA, USA.

A case of pheochromocytoma producing vasoactive intestinal peptide (VIP) and left ventricular thrombus in the absence of cardiomyopathy or wall motion abnormalities on echocardiogram is presented along with a review of the relevant literature. A 30-year-old female of Afghani descent with past medical history of panic attacks presented with fever, cough, sore throat, vomiting, and was found to have an 11 cm adrenal mass consistent with primary adrenocortical adenoma versus carcinoma. Her tumor elicited catechols and vasoactive intestinal peptide. Read More

View Article and Full-Text PDF

Recurrent pheochromocytoma with catecholamine cardiomyopathy and left ventricular thrombus: a case report.

J Int Med Res 2021 Apr;49(4):3000605211007723

Department of Cardiology, Xinqiao Hospital, Army Medical University (Third Military Medical University), Chongqing, China.

Pheochromocytoma is a rare and usually benign tumor of the adrenal glands. We report a case of a 40-year-old woman with recurrent pheochromocytoma and catecholamine cardiomyopathy. She had no history of other types of tumors or connective tissue disease. Read More

View Article and Full-Text PDF

Changes in the Size of a Ruptured Pheochromocytoma after Transcatheter Arterial Embolization.

Case Rep Med 2021 4;2021:5568978. Epub 2021 Apr 4.

Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan.

The spontaneous rupture of a pheochromocytoma is rare and can be potentially fatal. We report a case of a tumor size reduction of a ruptured pheochromocytoma after transcatheter arterial embolization (TAE). A 60-year-old Japanese woman was referred to the emergency department of another hospital with a sudden onset of left lateral pain. Read More

View Article and Full-Text PDF

Acute cardiac complications and subclinical myocardial injuries associated with pheochromocytoma and paraganglioma.

BMC Cardiovasc Disord 2021 Apr 21;21(1):203. Epub 2021 Apr 21.

Department of Cardiology, The First Affiliated Hospital of Soochow University, 188 Shizi Road, Suzhou City, 215006, People's Republic of China.

Background: Catecholamine excess arising from pheochromocytomas and paragangliomas (PPGLs) can cause a wide spectrum of cardiac manifestations, including acute cardiac complications (ACCs) and subclinical myocardial injuries (SMIs). In this study, we aimed to conduct a comprehensive analysis of ACCs and SMIs in a large cohort of patients with PPGLs.

Methods: We retrospectively analyzed the clinical data of consecutive patients with PPGLs admitted between January 2013 and July 2020 (n = 189). Read More

View Article and Full-Text PDF

Adrenal Incidentaloma.

Authors:
Electron Kebebew

N Engl J Med 2021 Apr;384(16):1542-1551

From the Division of General Surgery, Department of Surgery, Stanford University School of Medicine, Stanford, CA.

View Article and Full-Text PDF