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    [Adrenal surgery : Multidisciplinarity is mandatory].
    Rev Med Suisse 2017 Jun;13(567):1253-1257
    Service de chirurgie viscérale, CHUV, 1011 Lausanne.
    Adrenal tumours are rare and their management is challenging. Every patient presenting with adrenal mass or symptoms of hormones hypersecretion should be investigated. The two important questions to be answered are : 1. Read More

    Thyrotoxic and pheochromocytoma multisystem crisis: a case report.
    J Med Case Rep 2017 Jun 23;11(1):173. Epub 2017 Jun 23.
    Department of Emergency and Disaster Medicine, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu, 501-1194, Japan.
    Background: Thyrotoxic crisis and pheochromocytoma multisystem crisis are rare, life-threatening, emergency endocrine diseases with various clinical manifestations. Here we report a case of a patient who simultaneously developed thyrotoxic crisis and pheochromocytoma multisystem crisis and required intensive cardiovascular management.

    Case Presentation: A 60-year-old Asian man experienced nausea and vomiting, and subsequently developed dyspnea and cold sweats while farming. Read More

    Cushing Syndrome: Diagnostic Workup and Imaging Features, With Clinical and Pathologic Correlation.
    AJR Am J Roentgenol 2017 Jul;209(1):19-32
    1 Department of Diagnostic Radiology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030.
    Objective: Cushing syndrome (CS) is a constellation of clinical signs and symptoms resulting from chronic exposure to excess cortisol, either exogenous or endogenous. Exogenous CS is most commonly caused by administration of glucocorticoids. Endogenous CS is subdivided into two types: adrenocorticotropic hormone (ACTH) dependent and ACTH independent. Read More

    [Diabetes mellitus secondary to an endocrine pathology : when to think about it ?]
    Rev Med Suisse 2017 May;13(565):1158-1162
    Service d'endocrinologie, diabétologie, hypertension et nutrition, HUG, 1211 Genève 14.
    An endocrine disease can be associated with glucose intolerance or diabetes mellitus, and the latter can falsely be considered as type 2 diabetes. Glycemic imbalance can be a direct or indirect consequence of excessive hormone production. Endocrine diseases such as acromegaly, Cushing's syndrome and pheochromocytoma can increase glucose production and cause insulin resistance. Read More

    NEUROPROTECTIVE EFFECT OF TERMINALIA CHEBULA EXTRACTS AND ELLAGIC ACID IN PC12 CELLS.
    Afr J Tradit Complement Altern Med 2017 5;14(4):22-30. Epub 2017 Jun 5.
    Department of Nursing, HungKuang University, Taichung City, Taiwan (R.O.C.).
    Background: Alzheimer's disease (AD) is one of the common neurodegenerative disorders among elderly. The purpose of this study was to determine the neuroprotective effect and mechanisms of action underlying the Terminalia chebula extracts and ellagic acid by using beta-amyloid25-35 (Aβ25-35)-induced cell toxicity in an undifferentiated pheochromocytoma (PC12) cell line.

    Materials And Methods: The T. Read More

    The NF1 somatic mutational landscape in sporadic human cancers.
    Hum Genomics 2017 Jun 21;11(1):13. Epub 2017 Jun 21.
    Division of Cancer and Genetics, Institute of Medical Genetics, Cardiff University, Heath Park, Cardiff, CF14 4XN, UK.
    Background: Neurofibromatosis type 1 (NF1: Online Mendelian Inheritance in Man (OMIM) #162200) is an autosomal dominantly inherited tumour predisposition syndrome. Heritable constitutional mutations in the NF1 gene result in dysregulation of the RAS/MAPK pathway and are causative of NF1. The major known function of the NF1 gene product neurofibromin is to downregulate RAS. Read More

    [Hereditary pheochromocytoma-associated syndromes. Part 2].
    Ter Arkh 2015 ;87(10):115-119
    Endocrinology Research Center, Ministry of Health of Russia, Moscow, Russia.
    Pheochromocytoma (PCC)/paraganglioma is a catecholamine-secreting tumor of the paraganglion. The hereditary variants of PCC have been previously considered to occur in 10% of cases. The latest researches have clearly demonstrated that the hereditary cause of chromaffin tumors is revealed in a much larger number of patients. Read More

    Transdermal Nicotine : A Review of its Pharmacodynamic and Pharmacokinetic Properties, and Therapeutic Efficacy as an Aid to Smoking Cessation.
    Drugs 1992 Sep;44(3):498-529
    Adis International Limited, 41 Centorian Drive, Private Bag 65901, Mairangi Bay, Auckland 10, New Zealand.
    Synopsis: Transdermal nicotine delivery systems are a cigarette smoking cessation aid designed to deliver nicotine into the systemic circulation via the skin. The partial replacement of plasma nicotine, which would have otherwise been obtained from cigarettes, reduces the severity of nicotine withdrawal symptoms, and so allows the smoker to abstain from smoking more easily. The systems are available in 16- and 24-hour application regimens, and are recommended for daily use for up to 20 weeks, including a series of weaning-off courses. Read More

    Epigenetics of pheochromocytoma and paraganglioma.
    Mol Cell Endocrinol 2017 Jun 16. Epub 2017 Jun 16.
    Experimental Surgery, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.
    Pheochromocytomas and paragangliomas (PPGLs) are neuroendocrine tumors arising in the medullae of the adrenal glands or in paraganglia. The knowledge of the tumor biology of these lesions has increased dramatically during the past two decades and more than a dozen recurrently mutated genes have been identified. Different clusters have been described that share epigenetic signatures. Read More

    Compositional Characteristics and In Vitro Evaluations of Antioxidant and Neuroprotective Properties of Crude Extracts of Fucoidan Prepared from Compressional Puffing-Pretreated Sargassum crassifolium.
    Mar Drugs 2017 Jun 18;15(6). Epub 2017 Jun 18.
    Department of Seafood Science, National Kaohsiung Marine University, No. 142, Haijhuan Rd., Nanzih District, Kaohsiung 81157, Taiwan.
    Fucoidan, a fucose-containing sulfated polysaccharide with diverse biological functions, is mainly recovered from brown algae. In this study, we utilized a compressional-puffing process (CPP) to pretreat Sargassum crassifolium (SC) and extracted fucoidans from SC by warm water. Three fucoidan extracts (SC1: puffing at 0 kg/cm²; SC2: puffing at 1. Read More

    A Case of Retroperitoneal Paraganglioma.
    J UOEH 2017 ;39(2):161-166
    Department of Surgery 1, School of Medicine, University of Occupational and Environmental Health.
    We report a surgical case of retroperitoneal paraganglioma. A paraganglioma is a catecholamine-producing tumor originating in the chromaffin cells of the sympathetic ganglion. It is a kind of pheochromocytoma which occurs on the outside of the adrenal gland. Read More

    An unusual manifestation of diabetic ketoacidosis and acute colonic pseudo-obstruction.
    JRSM Open 2017 Jun 5;8(6):2054270417698632. Epub 2017 Jun 5.
    Department of Medicine, University of California, San Francisco, CA 94143, USA.
    Patients presenting with diabetic ketoacidosis and acute colonic pseudo-obstruction should undergo a focused evaluation to identify underlying precipitants. Read More

    Von Hippel-Lindau and Hereditary Pheochromocytoma/Paraganglioma Syndromes: Clinical Features, Genetics, and Surveillance Recommendations in Childhood.
    Clin Cancer Res 2017 Jun;23(12):e68-e75
    Division of Endocrinology, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
    Von Hippel-Lindau disease (vHL) is a hereditary tumor predisposition syndrome that places affected individuals at risk for multiple tumors, which are predominantly benign and generally occur in the central nervous system or abdomen. Although the majority of tumors occur in adults, children and adolescents with the condition develop a significant proportion of vHL manifestations and are vulnerable to delayed tumor detection and their sequelae. Although multiple tumor screening paradigms are currently being utilized for patients with vHL, surveillance should be reassessed as the available relevant clinical information continues to expand. Read More

    Design, synthesis, immunocytochemistry evaluation, and molecular docking investigation of several 4-aminopyridine derivatives as potential neuroprotective agents for treating Parkinson's disease.
    Bioorg Chem 2017 May 31;73:63-75. Epub 2017 May 31.
    School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, PR China. Electronic address:
    Neuroprotection refers to the relative preservation of neuronal structure and function. Neuroprotective agents refer to substances that are capable of preserving brain function and structure. Currently, there are no neuroprotective agents available that can effectively relieve the progression of Parkinson's disease. Read More

    THE PHYSIOLOGY BEHIND DIABETES MELLITUS IN PATIENTS WITH PHEOCHROMOCYTOMA: A REVIEW OF THE LITERATURE.
    Endocr Pract 2017 Jun 14. Epub 2017 Jun 14.
    From: Department of internal medicine. Division of Endocrinology, Diabetes and Nutrition; University of Maryland School of Medicine.
    Objective: This paper reviews the physiological mechanisms responsible for glucose intolerance and diabetes mellitus in patients with pheochromocytoma.

    Methods: Google Scholar and PubMed were searched using the following key words: "diabetes,"pheochromocytoma,"adrenoreceptors,"and "hyperglycemia". All the articles that were retrieved and reviewed are in English language. Read More

    A selenium polysaccharide from Platycodon grandiflorum rescues PC12 cell death caused by H2O2 via inhibiting oxidative stress.
    Int J Biol Macromol 2017 Jun 10;104(Pt A):393-399. Epub 2017 Jun 10.
    College of Pharmacy, Beihua University, Jilin 132013, China. Electronic address:
    In this paper, a selenium polysaccharide (PGP1) was isolated from the radix of Platycodon grandiflorum. We investigated the protective capacity of PGP1 against the hydrogen peroxide (H2O2)-induced oxidative damage in cultured rat pheochromocytoma (PC12) cells. Cells were pretreated with various doses of PGP1 (50, 100 and 200μg/mL) for 24h before exposure to 0. Read More

    Malignant Pheochromocytoma and Paraganglioma: 272 Patients over 55 Years.
    J Clin Endocrinol Metab 2017 Jun 12. Epub 2017 Jun 12.
    Division of Endocrinology, Diabetes, and Nutrition, Mayo Clinic, Rochester, MN, USA.
    Context: Malignant pheochromocytoma (PHEO) and paraganglioma (PGL) are rare and knowledge of the natural history is limited.

    Objective: We aimed to describe baseline characteristics and outcomes of patients with malignant PHEO and PGL (PPGL) and to identify predictors of shorter survival.

    Design: Retrospective review of patients with malignant PPGL evaluated from 1960 to 2016. Read More

    Efficacy of Peptide Receptor Radionuclide Therapy (PRRT) for Functional Metastatic Paraganglioma and Phaeochromocytoma.
    J Clin Endocrinol Metab 2017 Jun 9. Epub 2017 Jun 9.
    Centre for Cancer Imaging, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
    Purpose: Treatment options for unresectable Paraganglioma (PGL)/Phaeochromocytoma (PCC), especially with uncontrolled secondary hypertension (HTN) are limited. Preliminary studies with PRRT suggest efficacy but data on HTN control and survival are lacking. We assessed PRRT outcomes in such patients from 2 referral centres. Read More

    Phaeochromocytoma in multiple endocrine neoplasia type 2: RET codon-specific penetrance and changes in management during the last four decades.
    Clin Endocrinol (Oxf) 2017 Jun 12. Epub 2017 Jun 12.
    Endocrine Practice, Heidelberg, Germany.
    Objectives: We describe phaeochromocytoma penetrance in multiple endocrine neoplasia type 2 (MEN2) according to RET protooncogene-specific mutations, and report changes in phaeochromocytoma diagnosis and management from 1968 to 2015.

    Design: This retrospective chart review included 309 MEN2 patients from one specialised ambulatory care centre. Phaeochromocytoma patients were categorised by diagnosis date: early, 1968-1996, n = 40; and recent, 1997-2015, n = 45. Read More

    Adrenal tumour bigger than 5 cm - what could it be? An analysis of 139 cases.
    Endokrynol Pol 2017 Jun 12. Epub 2017 Jun 12.
    Department of Surgery Clinic of Oncology Memorial M. Sklodowska-Curie Cancer Institute, Warsaw, Poland.
    Introduction: There is an increasing number of adrenal being tumours discovered incidentally during imaging examinations performed for many different indications. Radiological findings suggesting adrenal pathology may be caused by true adrenal tumours or by other retroperitoneal masses. Generally, the larger the tumour, the higher the possibility of adrenal cancer. Read More

    Heart combined with adrenal multiple pheochromocytomas.
    J Nucl Cardiol 2017 Jun 7. Epub 2017 Jun 7.
    Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, No. 246 Xuefu Road, Harbin, Heilongjiang Province, China.
    Pheochromocytoma is a kind of rare tumor, occurring at any site in the sympathoadrenal system. Main lesions occur within the adrenal gland; only 1%-2% occur within the chest, and most of these are located in the posterior mediastinum. Intrapericardial pheochromocytoma is extremely rare in clinic, only about 100 cases have been reported in total in both the domestic and foreignliterature since Besterman et al. Read More

    [The application of captopril challenge test in the diagnosis of primary aldosteronism].
    Zhonghua Nei Ke Za Zhi 2017 Jun;56(6):402-408
    Department of Endocrinology, Key Laboratory of Endocrinology, National Health and Family Planning Commission, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.
    Objective: To evaluate the value of captopril challenge test (CCT) in the diagnosis of primary aldosteronism (PA). Methods: A total of 674 patients [(45.0±13. Read More

    Mediation of insulin growth factor-1 in Alzheimer's disease and the mechanism of PRNP genetic expression and the PI3K/Akt signaling pathway.
    Exp Ther Med 2017 Jun 10;13(6):2763-2766. Epub 2017 Apr 10.
    Affiliated Hospital of Zunyi Medical College, Zunyi, Guizhou 563003, P.R. China.
    The aim of the study was to examine the mediation of insulin growth factor-1 (IGF-1) in Alzheimer's disease (AD), as well as the underlying mechanism of the PRNP genetic expression and PI3K/Akt signaling pathway. The Aβ25-35-incubated rat adrenal pheochromocytoma cell (PC12) in vitro was established, constituting the AD model. Different doses (0, 20, 40 and 80 ng/ml) of IGF-1 were used in PC12 cells and the level of PRNP mRNA was tested after 24 h using the quantitative PCR method and the level of APP protein was assessed using western blot analysis. Read More

    The usefulness of laparoscopic adrenalectomy in the treatment of adrenal neoplasms - a single-centre experience.
    Endokrynol Pol 2017 Jun 6. Epub 2017 Jun 6.
    Department of General and Endocrine Surgery, Medical University of Warsaw.
    Introduction: Adrenal neoplasms comprise about 10% of all tumours affecting this organ and constitute a significant, at first diagnostic and subsequently therapeutic, problem, especially since a relatively high proportion of neoplastic lesions are asymptomatic. The number of diagnosed metastases to adrenal glands is increasing. Surgical treatment involves both open surgery as well as laparoscopy. Read More

    Genetic status determines (18) F-FDG uptake in pheochromocytoma/paraganglioma.
    J Med Imaging Radiat Oncol 2017 Jun 5. Epub 2017 Jun 5.
    Department of Endocrinology, Seth G S Medical College and KEM Hospital, Mumbai, India.
    Introduction: Although few studies have demonstrated utility of (18) F- fluoro-2-deoxy-d-glucose positron emission tomography/computerised tomography ((18) F-FDG PET/CT) in benign pheochromocytoma/paragangliomas (PCC/PGLs), there limited data on factors predicting the FDG uptake in PCC/PGL.

    Methods: The study was conducted at a tertiary health care centre. In addition to the routine investigations, all patients (n = 96) with PCC/PGL were evaluated with (18) F-FDGPET/CT and majority (n = 78) underwent (131) I-metaiodobenzyl guanidine ((131) I-MIBG) scintigraphy. Read More

    Fluorine-18-fluorodihydroxyphenylalanine Positron-emission Tomography Scans of Neuroendocrine Tumors (Carcinoids and Pheochromocytomas).
    J Clin Imaging Sci 2017 22;7:20. Epub 2017 May 22.
    Feinstein Institute for Medical Research, Northwell Health, Manhasset, NY, USA.
    Objectives: Conventional methods of imaging neuroendocrine tumors with computed tomography, magnetic resonance imaging, indium-111-octreotide, or radiolabeled metaiodobenzilguanidine scintigraphy have limitations. This pilot study tried to improve the localization of these tumors with fluorine-18-fluorodihydroxyphenylalanine (F-DOPA) positron-emission tomography (PET) scanning.

    Materials And Methods: We studied 22 patients, the majority of whom were referred with clinical diagnosis or suspicion of carcinoid (n = 11), neuroendocrine tumors (n = 7) or pheochromocytoma/paraganglioma (PGL) (n = 4). Read More

    Comparison of neurons derived from mouse P19, rat PC12 and human SH-SY5Y cells in the assessment of chemical- and toxin-induced neurotoxicity.
    BMC Pharmacol Toxicol 2017 Jun 5;18(1):42. Epub 2017 Jun 5.
    Department of Pharmacology and Clinical Neuroscience, Umeå University, Umeå, Sweden.
    Background: Exposure to chemicals might be toxic to the developing brain. There is a need for simple and robust in vitro cellular models for evaluation of chemical-induced neurotoxicity as a complement to traditional studies on animals. In this study, neuronally differentiated mouse embryonal carcinoma P19 cells (P19 neurons) were compared with human neuroblastoma SH-SY5Y cells and rat adrenal pheochromocytoma PC12 cells for their ability to detect toxicity of methylmercury (MeHg), okadaic acid and acrylamide. Read More

    Lower bone mass and higher bone resorption in pheochromocytoma: Importance of sympathetic activity on human bone.
    J Clin Endocrinol Metab 2017 Jun 5. Epub 2017 Jun 5.
    Division of Endocrinology and Metabolism, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea.
    Context: Despite the apparent biological importance of sympathetic activity on bone metabolism in rodents, its role in humans remains questionable.

    Objective: To clarify the link between the sympathetic nervous system and the skeleton in humans.

    Design, Setting, And Patients: Among 620 consecutive subjects with newly diagnosed adrenal incidentaloma, 31 patients with histologically confirmed pheochromocytoma (a catecholamine-secreting neuroendocrine tumor) and 280 patients with nonfunctional adrenal incidentaloma were defined as cases and controls, respectively. Read More

    Genetic diagnosis of a Chinese multiple endocrine neoplasia type 2A family through whole genome sequencing.
    J Biosci 2017 Jun;42(2):209-218
    Department of Oncologic and Urologic Surgery, Nanjing Military Command Hospital Center for Endocrine and Metabolic Diseases, Wenzhou Medical University, 40 Jichang Road, Hangzhou 310004,Zhejiang Province, China.
    Approximately 98% of patients with multiple endocrine neoplasia type 2A (MEN 2A) have an identifiable RET mutation. Prophylactic or early total thyroidectomy or pheochromocytoma/parathyroid removal in patients can be preventative or curative and has become standard management. The general strategy for RET screening on family members at risk is to sequence the most commonly affected exons and, if negative, to extend sequencing to additional exons. Read More

    Pheochromocytomatosis associated with a novel TMEM127 mutation.
    Endocrinol Diabetes Metab Case Rep 2017 25;2017. Epub 2017 May 25.
    Section of Endocrine Surgery, UCLA David Geffen School of Medicine, Los Angeles, USA.
    Pheochromocytomatosis, a very rare form of pheochromocytoma recurrence, refers to new, multiple, and often small pheochromocytomas growing in and around the surgical resection bed of a previous adrenalectomy for a solitary pheochromocytoma. We here report a case of pheochromocytomatosis in a 70-year-old female. At age 64 years, she was diagnosed with a 6-cm right pheochromocytoma. Read More

    SDHB mutation carriers with malignant pheochromocytoma respond better to CVD.
    Endocr Relat Cancer 2017 May 31. Epub 2017 May 31.
    D Cohen, Dept of Medicine; Renal and Hypertension Division, University of Pennsylvania Perelman School of Medicine, Philadelphia, United States.
    Pheochromocytomas and paragangliomas (PCC/PGL) are tumors in the adrenal medulla and extra adrenal sites, respectively. About a quarter are metastatic, often with a long latency period. Some PCC/PGL are defined as clinically aggressive given extensive local invasion into adjacent normal tissue. Read More

    A practical approach to diagnosing endocrine hypertension.
    Nephrology (Carlton) 2017 May 27. Epub 2017 May 27.
    Centre for Endocrinology and Metabolism, Hudson Institute of Medical Research and Department of Endocrinology, Monash Health, Clayton, Victoria, Australia.
    Hypertension is a leading cardiovascular risk factor that remains difficult to manage in a large segment of the population. Secondary causes of hypertension, which are amenable to targeted treatment or even cure, may contribute to poor blood pressure control. The most common endocrine cause, primary aldosteronism, requires biochemical screening as there are often no symptoms or signs other than hypertension. Read More

    Cytosolic Cl- Affects the Anticancer Activity of Paclitaxel in the Gastric Cancer Cell Line, MKN28 Cell.
    Cell Physiol Biochem 2017 11;42(1):68-80. Epub 2017 May 11.
    Department of Molecular Cell Physiology, Kyoto Prefectural University of Medicine, Kyoto, Japan.
    Background/aims: Our previous study revealed that cytosolic Cl- affected neurite elongation promoted via assembly of microtubule in rat pheochromocytoma PC12D cells and Cl--induced blockade of intrinsic GTPase enhanced tubulin polymerization in vitro. Paclitaxel (PTX) is a microtubule-targeted chemotherapeutic drug and stabilizes microtubules resulting in mainly blockade of mitosis at the metaphase-anaphase transition and induction of apoptosis. In the present study, we tried to clarify whether the cytosolic Cl- affected PTX ability to inhibit cell growth in the gastric cancer cell line, MKN28. Read More

    Characteristics of Pediatric Pheochromocytoma/paraganglioma.
    Indian J Endocrinol Metab 2017 May-Jun;21(3):470-474
    Department of Endocrinology, Vydehi Institute of Medical Sciences and Research Center, Bengaluru, Karnataka, India.
    The "rule of 10" used to describe pheochromocytoma/paragangliomas (PCC/PGLs) has been challenged. However, recent studies suggested that pediatric PCC/PGLs may follow a pattern. Hence, we reviewed the available literature to verify the same. Read More

    Incidental Detection of Synchronous Medullary Thyroid Carcinoma with Bilateral Adrenal Pheochromocytoma on Iodine-123 Metaiodobenzylguanidine Scintigraphy, Leading to Diagnosis of Multiple Endocrine Neoplasia 2A.
    World J Nucl Med 2017 Apr-Jun;16(2):169-171
    Department of Nuclear Medicine and Molecular Imaging, University at Buffalo, Jacobs School of Medicine and Biomedical Sciences, Buffalo, New York, USA.
    We report a case of a 29-year-old female with the family history of medullary thyroid carcinoma (MTC) presenting with hematuria and tachycardia, who was found to have bilateral adrenal masses on abdominal computed tomography and biochemical testing compatible with pheochromocytoma. Iodine-123 (I-123) metaiodobenzylguanidine (MIBG) scintigraphy for preoperative planning prior to planned adrenalectomy revealed incidental synchronous unifocal MTC, along with expected bilateral adrenal pheochromocytomas. Pathology confirmed these findings, and subsequent genetic testing confirmed a rearranged during transfection proto-oncogene mutation on exon 11, confirming the clinical diagnosis of multiple endocrine neoplasia 2A (MEN 2A). Read More

    PheoSeq: A Targeted Next-Generation Sequencing Assay for Pheochromocytoma and Paraganglioma Diagnostics.
    J Mol Diagn 2017 May 25. Epub 2017 May 25.
    Hereditary Endocrine Cancer Group, Spanish National Cancer Research Centre, Madrid, Spain; Centro de Investigacion Biomedica en Red de Enfermedades Raras, Madrid, Spain. Electronic address:
    Genetic diagnosis is recommended for all pheochromocytoma and paraganglioma (PPGL) cases, as driver mutations are identified in approximately 80% of the cases. As the list of related genes expands, genetic diagnosis becomes more time-consuming, and targeted next-generation sequencing (NGS) has emerged as a cost-effective tool. This study aimed to optimize targeted NGS in PPGL genetic diagnostics. Read More

    Antioxidant and Cytoprotective Activities of Grapevine Stilbenes.
    J Agric Food Chem 2017 Jun 7;65(24):4952-4960. Epub 2017 Jun 7.
    EA 4577, Unité de Recherche Oenologie, Université Bordeaux, ISVV , F-33882 Villenave d'Ornon, France.
    Grapevine stem extracts are viticulture byproducts rich in stilbenes that are increasingly studied for their potential biological activities. This study aimed to investigate some biological activities of a grape byproduct with high stilbenoid content and to point out the molecules responsible of these beneficial activities. As a consequence, the extract was subjected to a bioguided fractionation and separation by centrifugal partition chromatography. Read More

    Minimally invasive resection of adrenal masses in infants and children: results of a European multi-center survey.
    Surg Endosc 2017 May 26. Epub 2017 May 26.
    Pediatric Surgery Unit, Women's and Children's Health Department, University of Padova, Padova, Italy.
    Background: Minimal access adrenal surgery (MAAS) for adrenal pathologies is the standard for many pediatric surgical centers. However, the literature offers few reports and minimal evidence from small case series. The aim of this study was to evaluate the outcomes of pediatric MAAS through a multi-center data analysis. Read More

    Significant decreases in blood propofol concentrations during adrenalectomy for phaeochromocytoma.
    Br J Clin Pharmacol 2017 May 26. Epub 2017 May 26.
    Division of Anaesthesiology, Niigata University Graduate School of Medical and Dental Sciences, 1-754 Asahimachi-dori, Chuo-ku, Niigata, 951-8520, Japan.
    Aim: The kinetics of propofol are influenced by cardiac output. The aim of this study was to examine changes in blood propofol concentrations during phaeochromocytoma surgery using target-controlled infusion (TCI) anaesthesia with propofol.

    Methods: This is a prospective observational study. Read More

    The role of chalcones: helichrysetin, xanthohumol, and flavokawin-C in promoting neurite outgrowth in PC12 Adh cells.
    Nat Prod Res 2017 May 25:1-5. Epub 2017 May 25.
    b Faculty of Science, Mushroom Research Centre, Institute of Biological Sciences , University of Malaya , Kuala Lumpur , Malaysia.
    Chalcones are a group of compounds widely distributed in plant kingdom. The aim of this study was to assess the neurite outgrowth stimulatory activity of selected chalcones, namely helichrysetin, xanthohumol and flavokawin-C. Using adherent rat pheochromocytoma (PC12 Adh) cells, the chalcones were subjected to neurite outgrowth assay and the extracellular nerve growth factor (NGF) levels were determined. Read More

    Single-stage laparoscopic adrenalectomy for pheochromocytoma and enucleation of a pancreatic neuroendocrine tumor in Von Hippel-Lindau disease: A case report.
    Mol Clin Oncol 2017 May 6;6(5):799-801. Epub 2017 Apr 6.
    Department of Surgery, IRCCS - Azienda Ospedaliera Universitaria San Martino-IST, University of Genoa, Ι-16132 Genoa, Italy.
    Von Hippel-Lindau (VHL) disease is an inherited syndrome with autosomal-dominant transmission, characterized by central nervous system and retinal hemangioblastomas, visceral cysts and tumors. Optimal surgical treatment, including its timing, remains a controversial topic. The present study reports the case of a 67-year-old female patient with adrenal and pancreatic manifestations of VHL. Read More

    Diagnostic Imaging of Pregnant Women - The Role of Magnetic Resonance Imaging.
    Pol J Radiol 2017 19;82:220-226. Epub 2017 Apr 19.
    Clinic of Obstetrics and Gynecology, Institute of Mother and Child, Warsaw, Poland.
    Background: Presentation of magnetic resonance imaging (MRI) findings in pregnant women in the Department of Diagnostic Imaging, Institute of Mother and Child, Warsaw, Poland.

    Material/methods: Forty-three symptomatic pregnant women underwent MRI between 9 and 33 weeks of gestation (mean of 23 weeks). Moreover, we included 2 pregnant women who underwent fetal MRI and had incidental abnormalities. Read More

    Application of Panel-Based Tests for Inherited Risk of Cancer.
    Annu Rev Genomics Hum Genet 2017 May 15. Epub 2017 May 15.
    Division of Translational Medicine and Human Genetics, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania 19104; email:
    Next-generation or massively parallel sequencing has transformed the landscape of genetic testing for cancer susceptibility. Panel-based genetic tests evaluate multiple genes simultaneously and rapidly. Because these tests are frequently offered in clinical settings, understanding their clinical validity and utility is critical. Read More

    The Penetrance of Paraganglioma and Pheochromocytoma in SDHB germline mutation carriers.
    Clin Genet 2017 May 14. Epub 2017 May 14.
    Department of Otorhinolaryngology - Head Neck Surgery, VU University Medical Center, Amsterdam, the Netherlands.
    Germline mutations in SDHB predispose to hereditary paraganglioma syndrome type 4. The risk of developing paraganglioma (PGL) or pheochromocytoma (PHEO) in SDHB mutation carriers is subject of recent debate. In the present nationwide cohort study of SDHB mutation carriers identified by the clinical genetics centers of the Netherlands, we have calculated the penetrance of SDHB associated tumors using a novel maximum likelihood estimator. Read More

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