21,581 results match your criteria Pheochromocytoma


Effect of the nervous system on cancer: Analysis of clinical studies.

Bratisl Lek Listy 2019 ;120(2):119-123

Preclinical data have shown that neurotransmitters released in peripheral tissues from nerve endings may influence carcinogenesis, affect the tumor microenvironment, and directly potentiate both proliferation and migration of cancer cells. This stimulatory role of the nervous system in cancer initiation and progression has also been documented by clinical studies investigating the effect of attenuated signaling from nerves innervating cancer tissue. However, compared to preclinical studies, clinical studies are rarer and some of them have ambiguous results. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4149/BLL_2019_019DOI Listing
January 2019

Apogossypolone acts as a metastasis inhibitor via up-regulation of E-cadherin dependent on the GSK-3/AKT complex.

Am J Transl Res 2019 15;11(1):218-232. Epub 2019 Jan 15.

Department of Urology, Ruijin Hospital Affiliated to Medical School of Shanghai Jiaotong University Number 197, Ruijin'er Road, Huangpu District, Shanghai 200001, China.

Malignant pheochromocytoma is exactly diagnosed only upon the occurrence of metastatic foci. At that point, however, patients are less likely to experience many benefits from traditional chemotherapy. Therefore, a strategy worthy of consideration is inhibition or delay of metastasis with drugs. Read More

View Article

Download full-text PDF

Source
January 2019

Paraganglioma in pregnancy: interdisciplinary management during pregnancy.

Gynecol Endocrinol 2019 Feb 21:1-4. Epub 2019 Feb 21.

a High Complexity Obstetric Unit, Department of Gynecology and Obstetrics , Fundación Valle del Lili , Santiago de Cali , Colombia.

Paragangliomas are tumors that originate from the extra-adrenal neural crest, the incidence of which during pregnancy is not more than two to eight cases per million people per year and are known to be highly morbid. The purpose of this report is to describe the experience and results obtained during management of a primigravida diagnosed with paraganglioma on week 21.2 and received both medical and surgical management with good maternal and perinatal outcomes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/09513590.2019.1576619DOI Listing
February 2019

[Rheum turkestanicum reduces glutamate toxicity in PC12 and N2a cell lines].

Folia Neuropathol 2018 ;56(4):354-361

Glutamate is considered to be responsible for the pathogenesis of many neurodegenerative diseases. Reactive oxygen species (ROS) production is considered to be involved in the glutamate-induced apoptosis process. In this study, we investigated the neuroprotective effects of Rheum turkestanicum in the glutamate-induced rat pheochromocytoma (PC12 cells) and mouse neuroblastoma (N2a) cell lines. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5114/fn.2018.80869DOI Listing
January 2018

Management of adrenal incidentaloma.

Authors:
Darko Kastelan

Expert Rev Endocrinol Metab 2011 Nov;6(6):811-817

a School of Medicine, University of Zagreb, Zagreb, Croatia and Department of Endocrinology, University Hospital Zagreb, Zagreb, Croatia.

The term adrenal incidentaloma covers a wide spectrum of adrenal pathologies sharing the method of discovery. The management of adrenal incidentaloma is controversial, and clinicians should determine whether the patient's health is affected by the presence of a tumor. Critical points in management include differentiating benign from malignant and hormonally active from nonfunctional adrenal masses. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1586/eem.11.75DOI Listing
November 2011

Genetics of chromaffin tumors.

Expert Rev Endocrinol Metab 2009 Mar;4(2):143-151

a Université Paris Descartes, Paris, F-75006, France and INSERM, U 970, Paris, F-75015, France and Collège de France, Paris, F-75005, France and Assistance Publique-Hôpitaux de Paris, Département de Génétique, Hôpital Européen Georges Pompidou, 20-40 Rue Leblanc, 75015 Paris, France.

The old term of 'chromaffin tumors' encompasses both pheochromocytomas (PHs) and paragangliomas (PGLs). The identification of SDHx genes - new mitochondrial tumor-suppressor genes involved in hypoxia/angiogenesis pathways causing hereditary PGL/PH syndromes - has dramatically changed the genetics of chromaffin tumors. Between 25 and 30% of PGLs/PHs are inherited and are caused by a germline mutation in one of the six susceptibility genes (NF1, RET, VHL, SDHD, SDHB and SDHC). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1586/17446651.4.2.143DOI Listing

Fabrication and characterization of collagen-heparin-polypyrrole composite conductive film for neural scaffold.

Int J Biol Macromol 2019 Feb 15. Epub 2019 Feb 15.

Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Pharmaceutical Sciences, Jiangnan University, Wuxi 214122, China. Electronic address:

In this work, a conductive film consisted of polypyrrole-heparin-collagen (PHC film) was fabricated as a potential neural scaffold. Heparin was initially modified with pyrrole, which was further polymerized with pyrrole monomer under the catalysis of ferric trichloride. Then collagen was added and crosslinked through amide bond, as well as physical interaction with pyrrole through hydrogen bond. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijbiomac.2019.02.087DOI Listing
February 2019

Adrenal Collision Tumor Composed of Pheochromocytoma and Diffuse Large B-Cell Lymphoma: A Case Report.

Int J Hematol Oncol Stem Cell Res 2018 Oct;12(4):249-252

Department of Pathology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Adrenal involvement in the course of malignant lymphoma occurs in about 4% of patients, but primary adrenal lymphoma (PAL) is extremely rare. To the best of our knowledge, only one case study reported the combination of PAL with pheochromocytoma. In the current study, we present the second case who was a 63-year-old man admitted to our hospital with hematuria and abdominal discomfort. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375380PMC
October 2018

The Value of Histological Algorithms to Predict the Malignancy Potential of Pheochromocytomas and Abdominal Paragangliomas-A Meta-Analysis and Systematic Review of the Literature.

Cancers (Basel) 2019 Feb 15;11(2). Epub 2019 Feb 15.

Department of Oncology-Pathology, Karolinska Institutet, 171 76 Stockholm, Sweden.

Pheochromocytomas (PCCs) and abdominal paragangliomas (PGLs), collectively abbreviated PPGLs, are neuroendocrine tumors of the adrenal medulla and paraganglia, respectively. These tumors exhibit malignant potential but seldom display evidence of metastatic spread, the latter being the only widely accepted evidence of malignancy. To counter this, pre-defined histological algorithms have been suggested to stratify the risk of malignancy: Pheochromocytoma of the Adrenal Gland Scaled Score (PASS) and the Grading system for Adrenal Pheochromocytoma and Paraganglioma (GAPP). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/cancers11020225DOI Listing
February 2019
2 Reads

Expression of PDK1 in malignant pheochromocytoma as a new promising potential therapeutic target.

Authors:
X Zhang Z Yu

Clin Transl Oncol 2019 Feb 13. Epub 2019 Feb 13.

Department of Urology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.

Purpose: Phosphoinositide-dependent kinase 1 (PDK1) is highly expressed in many solid tumors. And several studies have demonstrated that PDK1 has been an emerging and promising target for anti-cancer therapies. However, the role of PDK1 has not been studied so far in malignant pheochromocytoma (PCC). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12094-019-02055-5DOI Listing
February 2019

[Preoperative genetic diagnostics and imaging for pediatric pheochromocytoma and paraganglioma].

Authors:
H Dralle

Chirurg 2019 Feb 13. Epub 2019 Feb 13.

Sektion Endokrine Chirurgie, Klinik für Allgemein‑, Viszeral- und Transplantationschirurgie, Universitätsklinikum Essen, Hufelandstr. 55, 45147, Essen, Deutschland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00104-019-0846-zDOI Listing
February 2019

Not So Incidental: Pheochromocytoma in an Adult with Unrepaired Cyanotic Heart Disease.

Eur J Case Rep Intern Med 2018 24;5(10):000959. Epub 2018 Oct 24.

Department of Internal Medicine, University of Western Ontario, London, Canada.

Pheochromocytoma, a rare neuroendocrine tumour, is often encountered in the general internal medicine clinic as an adrenal incidentaloma. Even rarer is its presence in adult cyanotic heart disease, although there are a few documented reports of this association in various paediatric populations, with chronic hypoxia being the likely driving force. Here we present the case of a 38-year-old adult with unrepaired complex cyanotic congenital heart disease with biochemically proven pheochromocytoma presenting as an adrenal incidentaloma to a general internal medicine clinic. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12890/2018_000959DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346887PMC
October 2018

Schwann Cell Precursors Generate the Majority of Chromaffin Cells in Zuckerkandl Organ and Some Sympathetic Neurons in Paraganglia.

Front Mol Neurosci 2019 25;12. Epub 2019 Jan 25.

Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.

In humans, neurosecretory chromaffin cells control a number of important bodily functions, including those related to stress response. Chromaffin cells appear as a distinct cell type at the beginning of midgestation and are the main cellular source of adrenalin and noradrenalin released into the blood stream. In mammals, two different chromaffin organs emerge at a close distance to each other, the adrenal gland and Zuckerkandl organ (ZO). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fnmol.2019.00006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355685PMC
January 2019
2 Reads

Efficacy and Safety of Ablative Therapy in the Treatment of Patients with Metastatic Pheochromocytoma and Paraganglioma.

Cancers (Basel) 2019 Feb 7;11(2). Epub 2019 Feb 7.

Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.

Metastatic pheochromocytoma and paraganglioma (PPGL) are incurable neuroendocrine tumors. The goals of treatment include palliating symptoms and reducing tumor burden. Little is known about the use of radiofrequency ablation (RFA), cryoablation (CRYO), and percutaneous ethanol injection (PEI) to treat metastatic PPGL. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/cancers11020195DOI Listing
February 2019

New and Emerging Biomarkers in Endocrine Pathology.

Adv Anat Pathol 2019 Feb 5. Epub 2019 Feb 5.

Department of Pathology, Massachusetts General Hospital.

Significant advances in genomics and molecular genetics in recent years have reshaped the practice of endocrine pathology. Pan-genomic studies, including the pioneering ones on papillary thyroid carcinoma, phaeochromocytoma/paraganglioma, and adrenal cortical carcinoma from the Cancer Genome Atlas (TCGA) project, provided a comprehensive integrated genomic analysis of endocrine tumors into distinct molecularly defined subtypes. Better understanding of the molecular landscape and more accurate definition of biological behavior has been accordingly achieved. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/PAP.0000000000000227DOI Listing
February 2019
1 Read

Combinatorial inhibition of mTORC2 and Hsp90 leads to a distinctly effective therapeutic strategy in malignant pheochromocytom.

Curr Cancer Drug Targets 2019 Feb 6. Epub 2019 Feb 6.

Department of Urology, Huashan Hospital Affiliated to Fudan University, Shanghai. China.

Background: Malignant pheochromocytoma (mPCC) is an uncommon tumor with poor prognosis, and no effective therapeutic strategy exists. Discovering new and effective therapeutic strategies to improve prognosis is an urgent need.

Objective: To investigate whether combinatorial inhibition of both mTORC2 and Hsp90 in PC12 cells could lead to a distinctly antitumor effect in vitro and in vivo that was greater than inhibition of mTORC2 or Hsp90 alone. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1568009619666190206120615DOI Listing
February 2019
2 Reads

Funny Lumps, Flaming Pheo, and a Broken Heart: A Rare Case of Pheochromocytoma.

Cureus 2018 Nov 28;10(11):e3646. Epub 2018 Nov 28.

Radiology, Florida Hospital-Orlando, Orlando, USA.

Pheochromocytoma is the underlying etiology in 0.1% of hypertensive cases. However, it may be present in up to 5. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7759/cureus.3646DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351109PMC
November 2018
2 Reads

Prognosis of malignant pheochromocytoma and paraganglioma (MAPP-Prono study): an ENS@T retrospective study.

J Clin Endocrinol Metab 2019 Feb 1. Epub 2019 Feb 1.

Department of Nuclear Medicine and Endocrine Tumors, Gustave Roussy, Villejuif, France.

Background: Malignant pheochromocytoma and paraganglioma (MPP) are characterized by prognostic heterogeneity. Our objective was to look for prognostic parameters of overall survival in MPP patients.

Patients And Methods: Retrospective multicentric study of MPP characterized by a neck-thoraco-abdomino-pelvic CT or MRI at the time of malignancy diagnosis in European centers between 1998 and 2010. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/jc.2018-01968DOI Listing
February 2019
3 Reads

PC 12 Pheochromocytoma Cell Response to Super High Frequency Terahertz Radiation from Synchrotron Source.

Cancers (Basel) 2019 Jan 31;11(2). Epub 2019 Jan 31.

School of Science, RMIT University, P.O. Box 2476, Melbourne, VIC 3001, Australia.

High frequency (HF) electromagnetic fields (EMFs) have been widely used in many wireless communication devices, yet within the terahertz (THz) range, their effects on biological systems are poorly understood. In this study, electromagnetic radiation in the range of 0.3⁻19. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/cancers11020162DOI Listing
January 2019
1 Read

Dysphagia: an unusual presentation of Von Hippel-Lindau disease.

Postgrad Med J 2019 Jan 30. Epub 2019 Jan 30.

Department of Endocrinology, Post Graduate Institute for Medical Education and Research, Chandigarh, India

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/postgradmedj-2018-136033DOI Listing
January 2019
1 Read

Positive Impact of Genetic Test on the Management and Outcome of Patients With Paraganglioma and/or Pheochromocytoma.

J Clin Endocrinol Metab 2019 Apr;104(4):1109-1118

Équipe Labellisée par la Ligue Contre le Cancer, INSERM, UMR970, Paris-Centre de Recherche Cardiovasculaire, Paris, France.

Context: Pheochromocytomas and paragangliomas (PPGLs) are characterized by a strong genetic component, with up to 40% of patients carrying a germline mutation in a PPGL susceptibility gene. International guidelines recommend that genetic screening be proposed to all patients with PPGL.

Objective: Our objective was to evaluate how a positive genetic test impacts the management and outcome of patients with SDHx or VHL-related PPGL. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/jc.2018-02411DOI Listing
April 2019
1 Read

Retrospective analysis of variant venous anatomy in 303 laparoscopic adrenalectomies and its clinical implications.

J Surg Oncol 2019 Jan 30. Epub 2019 Jan 30.

Shanghai Key Laboratory for Endocrine Tumors, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of Chinese Health Ministry, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Background And Objectives: To clarify the correlation of variant venous anatomy with adrenal tumor phenotype and surgical outcomes.

Patients And Methods: This retrospective study included 303 consecutive minimally invasive adrenalectomies from 301 patients. All adrenal veins were identified. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/jso.25364
Publisher Site
http://dx.doi.org/10.1002/jso.25364DOI Listing
January 2019
3 Reads

Synchronous renal cell carcinoma and pheochromocytoma presenting as acute decompensated heart failure.

J Postgrad Med 2019 Jan-Mar;65(1):44-46

Division of Cardiology, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.

We report a 49-year-old woman who presented with a hypertensive crisis and acute heart failure and reduced left ventricular systolic function. An abdominal ultrasonography revealed a huge lobulated heterogeneous mass at the lower pole of the right kidney and a mass over the left suprarenal area, which were further delineated by magnetic resonance imaging. The patient underwent laparoscopic right radical nephrectomy and left adrenalectomy. Read More

View Article

Download full-text PDF

Source
http://www.jpgmonline.com/text.asp?2019/65/1/44/250961
Publisher Site
http://dx.doi.org/10.4103/jpgm.JPGM_701_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380140PMC
January 2019
4 Reads

Propranolol: A 50-Year Historical Perspective.

Authors:
A V Srinivasan

Ann Indian Acad Neurol 2019 Jan-Mar;22(1):21-26

Former Professor of Neurology and Head - Institute of Neurology, Madras Medical College, Chennai, Emeritus Professor - The Tamil Nadu Dr. M.G.R. Medical University, Adjunct Professor - Indian Institute of Technology (IIT - Chennai), Tamil Nadu, India.

Propranolol is a beta-adrenergic receptor antagonist that was developed by the British scientist Sir James Black primarily for the treatment of angina pectoris, more than 50 years ago. It was not long before several other cardiovascular as well as noncardiovascular therapeutic uses of propranolol were discovered. Propranolol soon became a powerful tool for physicians in the treatment of numerous conditions such as hypertension, cardiac arrhythmias, myocardial infarction, migraine, portal hypertension, anxiety, essential tremors, hyperthyroidism, and pheochromocytoma. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/aian.AIAN_201_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327687PMC
January 2019
1 Read

Changes in blood pressure, blood sugar, and quality of life in patients undergoing pheochromocytoma surgery: a prospective cohort study.

Indian J Urol 2019 Jan-Mar;35(1):34-40

Department of Urology, All India Institute of Medical Sciences, New Delhi, India.

Introduction: Pheochromocytoma surgery is associated with significant hemodynamic and metabolic changes that require post-operative monitoring. We prospectively evaluated the trends of blood pressure, blood sugar, body mass index (BMI), and quality of life (QoL) changes in a cohort of patients undergoing pheochromocytoma surgery to determine the minimum duration of monitoring and assess factors that could predict these changes.

Materials And Methods: Consecutive patients undergoing surgery for pheochromocytoma over a 20-month period were included in this ethics review board-approved, prospective cohort study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/iju.IJU_190_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334590PMC
January 2019
7 Reads

MEN 2B masquerading as chronic blepharitis and euryblepharon.

Orbit 2019 Jan 27:1-5. Epub 2019 Jan 27.

c Ocular Pathology Department , Wills Eye Hospital , Philadelphia , PA , USA.

This is a retrospective case description of a single male patient found to have multiple endocrine neoplasia syndrome type 2B (MEN 2B). At the age of 14, he presented for evaluation of ocular irritation and eyelid thickening. Intraoperative assessment revealed mucosal lesions on the anterior dorsum of his tongue and biopsy of multiple eyelid lesions disclosed bilateral submucosal neuromas, leading to the diagnosis of MEN 2B. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/01676830.2019.1567800DOI Listing
January 2019
1 Read

Analysis of Gene Expression and Neuronal Phenotype in Neuroscreen-1 (NS-1) Cells.

Int J Biomed Investig 2018 Sep-Dec;1(3). Epub 2018 Dec 17.

Biomanufacturing Research Institute and Technology Enterprise (BRITE), North Carolina Central University, Durham, North Carolina, United States of America.

Neuroscreen-1 (NS-1) a sub-clone of pheochromocytoma (PC12) cell is gaining broad acceptance as in vitro neuronal model for biochemical and phenotypic assays due to robust growth and differentiation profiles. However, the molecular characteristics of the cell remains to be documented. In this study, we performed comparative analysis for expression of neuronal marker genes in undifferentiated and nerve growth factor (NGF) differentiated NS-1 and PC12 by qPCR and immunoblot assays. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345259PMC
December 2018

Laparoscopic bilateral anterior transperitoneal adrenalectomy: 24 years experience.

Surg Endosc 2019 Jan 23. Epub 2019 Jan 23.

Department of General Surgery and Surgical Specialties "Paride Stefanini", Sapienza University of Rome, Viale del Policlinico 155, 00161, Rome, Italy.

Background: The aim of this study is to evaluate the feasibility, safety, advantages and surgical outcomes of laparoscopic bilateral adrenalectomy (LBA) by an anterior transperitoneal approach.

Methods: From 1994 to 2018, 552 patients underwent laparoscopic adrenalectomy, unilateral in 531 and bilateral in 21 patients (9 females and 12 males). All patients who underwent LBA were approached via a transperitoneal anterior route and form our study population. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s00464-019-06665-6
Publisher Site
http://dx.doi.org/10.1007/s00464-019-06665-6DOI Listing
January 2019
7 Reads

Case of reversible diabetes mellitus in the setting of benign Pheochromocytoma.

J Clin Transl Endocrinol Case Rep 2018 Dec 2;10:1-3. Epub 2018 Aug 2.

Department of Medicine, Division of Diabetes, Endocrinology, and Metabolism, Vanderbilt University Medical Center, Nashville, TN, USA.

Pheochromocytomas have been shown to impair glucose tolerance and, rarely, to precipitate overt diabetes mellitus. We report here a case of a large pheochromocytoma in a woman with a recent diagnosis of diabetes mellitus that proved difficult to control despite high-dose insulin therapy who had complete resolution of her hyperglycemia following adrenalectomy. Her dramatic presentation demonstrates the need to consider this etiology in patients with new-onset insulin resistance and hypertension. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jecr.2018.07.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338797PMC
December 2018

Natural history, treatment, and long-term follow up of patients with multiple endocrine neoplasia type 2B: an international, multicentre, retrospective study.

Lancet Diabetes Endocrinol 2019 Mar 16;7(3):213-220. Epub 2019 Jan 16.

Endocrine Oncology, Institut Gustave Roussy Ecole Doctorale de Cancerologie, Villejuif, France.

Background: Multiple endocrine neoplasia type 2B is a rare syndrome caused mainly by Met918Thr germline RET mutation, and characterised by medullary thyroid carcinoma, phaeochromocytoma, and extra-endocrine features. Data are scarce on the natural history of multiple endocrine neoplasia type 2B. We aimed to advance understanding of the phenotype and natural history of multiple endocrine neoplasia type 2B, to increase awareness and improve detection. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S22138587183033
Publisher Site
http://dx.doi.org/10.1016/S2213-8587(18)30336-XDOI Listing
March 2019
6 Reads

Increased Mortality in but Not in Pathogenic Variant Carriers.

Cancers (Basel) 2019 Jan 17;11(1). Epub 2019 Jan 17.

Department of Otolaryngology/Head and Neck Surgery, Amsterdam UMC, Vrije Universiteit Amsterdam, De Boelelaan 1117, 1081 HZ Amsterdam, The Netherlands.

Germline mutations in succinate dehydrogenase subunit B and D ( and ) are predisposed to hereditary paraganglioma (PGL) and pheochromocytoma (PHEO). The phenotype of pathogenic variants varies according to the causative gene. In this retrospective study, we estimate the mortality of a nationwide cohort of variant carriers and that of a large cohort of variant carriers and compare it to the mortality of a matched cohort of the general Dutch population. Read More

View Article

Download full-text PDF

Source
http://www.mdpi.com/2072-6694/11/1/103
Publisher Site
http://dx.doi.org/10.3390/cancers11010103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356820PMC
January 2019
4 Reads

Pulsed electromagnetic field and relief of hypoxia-induced neuronal cell death: The signaling pathway.

J Cell Physiol 2019 Jan 17. Epub 2019 Jan 17.

Department of Medical Sciences, University of Ferrara, Ferrara, Italy.

Low-energy low-frequency pulsed electromagnetic fields (PEMFs) exert several protective effects, such as the regulation of kinases, transcription factors as well as cell viability in both central and peripheral biological systems. However, it is not clear on which bases they affect neuroprotection and the mechanism responsible is yet unknown. In this study, we have characterized in nerve growth factor-differentiated pheochromocytoma PC12 cells injured with hypoxia: (i) the effects of PEMF exposure on cell vitality; (ii) the protective pathways activated by PEMFs to relief neuronal cell death, including adenylyl cyclase, phospholipase C, protein kinase C epsilon and delta, p38, ERK1/2, JNK1/2 mitogen-activated protein kinases, Akt and caspase-3; (iii) the regulation by PEMFs of prosurvival heat-shock proteins of 70 (HSP70), cAMP response element-binding protein (CREB), brain-derived neurotrophic factor (BDNF), and Bcl-2 family proteins. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jcp.28149DOI Listing
January 2019
3 Reads

Malignant paraganglioma of the posterior mediastinum: A case report with genetic analysis.

Mol Clin Oncol 2019 Jan 8;10(1):10-16. Epub 2018 Nov 8.

Division of Gastroenterology, Department of Internal Medicine, Sapporo Shirakaba-dai Hospital, Sapporo, Hokkaido 062-0052, Japan.

Paraganglioma and pheochromocytoma are rare neuroendocrine neoplasms that originate from chromaffin cells. In many of these tumors, several mutations are reported to occur in the genes of germline and/or somatic cells. A case of paraganglioma in the posterior mediastinum with highly malignant potential is reported. Read More

View Article

Download full-text PDF

Source
http://www.spandidos-publications.com/10.3892/mco.2018.1758
Publisher Site
http://dx.doi.org/10.3892/mco.2018.1758DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6313888PMC
January 2019
7 Reads

Endocrinology: phaeochromocytoma.

Authors:
John Firth

Clin Med (Lond) 2019 Jan;19(1):68-71

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7861/clinmedicine.19-1-68DOI Listing
January 2019
2 Reads

Protective Role of SOCS3 Modified Bone Marrow Mesenchymal Stem Cells in Hypoxia-Induced Injury of PC12 Cells.

J Mol Neurosci 2019 Jan 15. Epub 2019 Jan 15.

Department of Infection, Linyi Central Hospital, Linyi, 276400, Shandong, China.

We attempted to explore the possible effects of SOCS3 (suppressor of cytokine signaling 3)-modified bone marrow mesenchymal stem cells (BMSCs) on the hypoxic injury of rat adrenal gland pheochromocytoma (PC-12) cells. PC12 cells were cultured with EGFP (enhanced green fluorescent protein)-BMSCs and SOCS3-BMSCs respectively under hypoxia in vitro and classified into control, hypoxia, EGFP-BMSCs, and SOCS3-BMSC groups. CCK-8, Hoechst 33258 staining, and Annexin V-FITC/PI staining were assessed to measure the viability and apoptosis of hypoxia-induced PC12 cells. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12031-018-1243-7DOI Listing
January 2019
1 Read

[The role of the AMPK-mTOR pathway in paraquat-induce autophagy in PC12 cells].

Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2018 Nov;36(11):801-807

School of Public Health, Ningxia Medical University, Yinchuan 750004, China.

To investigate the regulation of AMPK-mTOR signal transduction pathway in paraquat-induced autophagy of pheochromocytoma cells (PC12) . The PC12 cell were treated with terminal concentrations of 0, 25, 50, 100, 200, 300 and 400 μmol/L PQ for 24 hours, and the cells were induced by 300 μmol/L PQ for different time (6, 12, 24, 48 h) . MTT was used to detect the relative survival rate of cells, and the dose/time-effect relationship was determined respectively. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3760/cma.j.issn.1001-9391.2018.11.001DOI Listing
November 2018
3 Reads

Long-term follow-up of RET Y791F carriers in Denmark 1994-2017: A National Cohort Study.

J Surg Oncol 2019 Jan 15. Epub 2019 Jan 15.

Department of ORL, Head & Neck Surgery and Audiology, Odense University Hospital, Odense, Denmark.

Background And Objectives: Recently, a comprehensive study presented evidence that a long-disputed REarranged during Transfection (RET) variant, RET Y791F, should be classified as nonpathogenic. In spite of this, several subsequently published papers, including the revised American Thyroid Association guidelines for medullary thyroid carcinoma, refer to the variant as pathogenic. This study presents data from a unique national Danish cohort of RET Y791F carriers who have been followed by watchful waiting instead of being subjected to early thyroidectomy, to determine if any carrier shows evidence of multiple endocrine neoplasia 2A (MEN2A) at long-term follow-up. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/jso.25371
Publisher Site
http://dx.doi.org/10.1002/jso.25371DOI Listing
January 2019
6 Reads

Familial and Hereditary Forms of Primary Hyperparathyroidism.

Front Horm Res 2019 19;51:40-51. Epub 2018 Nov 19.

Individuals with a familial predisposition to the development of parathyroid tumors constitute a small minority of all patients with primary hyperparathyroidism (PHPT). These familial syndromes exhibit Mendelian inheritance patterns and the main causative genes in most families have been identified. They include multiple endocrine neoplasia (MEN; types 1, 2A, and 4), hyperparathyroidism-jaw tumor (HPT-JT) syndrome, familial isolated hyperparathyroidism, familial hypocalciuric hypercalcemia (FHH), and neonatal severe PHPT. Read More

View Article

Download full-text PDF

Source
https://www.karger.com/Article/FullText/491037
Publisher Site
http://dx.doi.org/10.1159/000491037DOI Listing
November 2018
3 Reads

Pheochromocytoma-related cardiomyopathy presenting as broken heart syndrome: Case report and literature review.

Int J Surg Case Rep 2019 Jan 9;55:7-10. Epub 2019 Jan 9.

Department of Surgery, Kendall Regional Medical Center, Miami, FL, United States.

Introduction: Pheochromocytoma are neuroendocrine tumors that arise from sympathetic chromaffin cells within the adrenal medulla. They principally secrete catecholamines, potentially causing life-threatening cardiovascular complications. A myriad of symptomatology and clinical findings are associated with pheochromocytoma, including a catecholamine-induced dilated cardiomyopathy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijscr.2018.12.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330378PMC
January 2019
1 Read

In vitro studies of the neuroprotective activities of astaxanthin and fucoxanthin against amyloid beta (Aβ) toxicity and aggregation.

Neurochem Int 2019 Mar 9;124:215-224. Epub 2019 Jan 9.

Centre for Marine Bioproducts Development (CMBD), College of Medicine and Public Health, Flinders University, GPO Box 2100, Adelaide, 5001, South Australia, Australia; Medical Biotechnology, College of Medicine and Public Health, Flinders University, GPO Box 2100, Adelaide, 5001, South Australia, Australia. Electronic address:

Amyloid beta (Aβ) can aggregate and form plaques, which are considered as one of the major hallmarks of Alzheimer's disease. This study aims to directly compare the neuroprotective activities in vitro of two marine-derived carotenoids astaxanthin and fucoxanthin that have shown a spectrum of biological activities, including neuroprotection. The in vitro neuroprotective activities were investigated against Aβ-mediated toxicity in pheochromocytoma (PC-12) neuronal cells using the MTT cell viability assay, anti-apoptotic, antioxidant and neurite outgrowth activities; as well as inhibition against Aβ fibrillization in the Thioflavin T (ThT) assay of fibril kinetics and via transmission electron microscopic (TEM) evaluation of fibril morphology. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S01970186183024
Publisher Site
http://dx.doi.org/10.1016/j.neuint.2019.01.010DOI Listing
March 2019
10 Reads

Neuroprotection of mangiferin against oxidative damage via arousing Nrf2 signaling pathway in PC12 cells.

Biofactors 2019 Jan 11. Epub 2019 Jan 11.

State Key Laboratory of Applied Organic Chemistry and College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, Gansu, China.

Accumulating evidence demonstrates that oxidative stress is involved in the pathogenesis and progression of neurodegeneration. As NF-E2-related factor 2 (Nrf2) plays a crucial role in maintaining cellular redox homeostasis, small molecules with the ability in activation of Nrf2 pathway are promising neuroprotective agents. Mangiferin (Mg) is a xanthone glucoside extracted from mangoes and papayas, and has been reported to possess multiple pharmacological activities. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/biof.1488
Publisher Site
http://dx.doi.org/10.1002/biof.1488DOI Listing
January 2019
4 Reads

Ga-DOTATOC PET/CT in the localization of metastatic extra-adrenal paraganglioma and pheochromocytoma compared with F-DOPA PET/CT.

Rev Esp Med Nucl Imagen Mol 2019 Jan 7. Epub 2019 Jan 7.

Department of Nuclear Medicine, Medical University Innsbruck, Innsbruck, Austria.

Objective: F-Fluoro-L-dihydroxyphenylalanine (F-DOPA) PET offers high sensitivity and specificity in the imaging of non-malignant extra-adrenal paraganglioma (PGL) and pheochromocytoma (PHEO) but lower sensitivity in metastatic disease. These tumours are of neuroendocrine origin and can be detected by Ga-DOTA-Tyr3-octreotide (Ga-DOTA-TOC) PET. Therefore, we compared Ga-DOTA-TOC and F-DOPA as radiolabels for PET/CT imaging for the diagnosis of metastatic extra-adrenal PGL and PHEO. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.remn.2018.09.004DOI Listing
January 2019
1 Read

L-NBP, a multiple growth factor activator, attenuates ischemic neuronal impairments possibly through promoting neuritogenesis.

Neurochem Int 2019 Mar 7;124:94-105. Epub 2019 Jan 7.

Beijing Institute of Brain Disorders & Research Center for Brain Disorders, Capital Medical University, Beijing, 100069, PR China; State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, PR China. Electronic address:

In China, L-3-n-butylphthalide (L-NBP) showed promising pharmacological actions in stroke treatment. Analyzing the characteristics of L-NBP might provide valuable hints for new drug design. The current study is aimed to determine the effects of L-NBP on neuritogenesis and further to elucidate the neuronal protection against stroke impairment in vitro. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S01970186183050
Publisher Site
http://dx.doi.org/10.1016/j.neuint.2019.01.002DOI Listing
March 2019
8 Reads

Commentary on an Acute Care Surgery Challenge: Abdominal Aortic Aneurysm and Pheochromocytoma.

Authors:
Michael J Sise

J Trauma Acute Care Surg 2019 Jan 8. Epub 2019 Jan 8.

From the Divisions of Trauma and Vascular Surgery, Scripps Mercy Hospital, San Diego, California.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/TA.0000000000002193DOI Listing
January 2019
8 Reads

Multidisciplinary approach for patients with functional and non-functional adrenal masses and review of the literature.

Health Sci Rep 2018 Mar 20;1(3):e22. Epub 2017 Dec 20.

Internal Medicine and Endocrinology, Department of Internal Medicine, Division of Endocrinology Cukurova University Medical Faculty Adana Turkey.

Background: Adrenal incidentalomas are adrenal masses that are discovered by imaging tests performed for other reasons.

Aims: In this retrospective study, we analysed 229 Turkish patients with adrenal masses and who presented with or without complaints.

Study Design: Descriptive retrospective study and review of the literature. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/hsr2.22
Publisher Site
http://dx.doi.org/10.1002/hsr2.22DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6266456PMC
March 2018
4 Reads

Impact of maternal pheochromocytoma on the fetus and neonate.

Authors:
Shigeo Iijima

Gynecol Endocrinol 2019 Jan 6:1-7. Epub 2019 Jan 6.

a Department of Regional Neonatal-Perinatal Medicine , Hamamatsu University School of Medicine , Shizuoka , Japan.

Pheochromocytoma during pregnancy is rare but potentially harmful to the mother and fetus. Fetal risks are mainly determined by the vasoconstrictive effects of maternal catecholamine on uteroplacental circulation, because the fetus is protected from the direct effects of high catecholamine levels at the placental interface. Uteroplacental insufficiency may lead to spontaneous abortion, fetal growth restriction, premature delivery, and fetal hypoxia, followed by fetal distress and/or birth asphyxia. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/09513590.2018.1540568DOI Listing
January 2019
2 Reads

Clinical Syndromes and Genetic Screening Strategies of Pheochromocytoma and Paraganglioma.

J Kidney Cancer VHL 2018 27;5(4):14-22. Epub 2018 Dec 27.

Department of Urology, Xiangya Hospital, Central South University, Changsha, China.

Pheochromocytomas (PCCs) are rare neuroendocrine tumors that originate from chromaffin cells of the adrenal medulla, and paragangliomas (PGLs) are extra-adrenal pheochromocytomas. These can be mainly found in clinical syndromes including multiple endocrine neoplasia (MEN), von Hippel-Lindau (VHL) syndrome, neurofibromatosis-1 (NF-1) and familial paraganglioma (FPGL). PCCs and PGLs are thought to have the highest degree of heritability among human tumors, and it has been estimated that 60% of the patients have genetic abnormalities. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.15586/jkcvhl.2018.113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6308242PMC
December 2018
1 Read