21,661 results match your criteria Pheochromocytoma


Morphological control of mitochondria as the novel mechanism of Gastrodia elata in attenuating mutant huntingtin-induced protein aggregations.

Phytomedicine 2018 Nov 14;59:152756. Epub 2018 Nov 14.

Department of Biotechnology and Animal Science, National Ilan University, Ilan, Taiwan, ROC. Electronic address:

Background: According to Compendium of Materia Medica, Gastrodia elata (GE) Blume as a top grade and frequently prescribed herbal medicine has been used in treating dizziness, headaches, and epilepsy, indicating a neuroprotective effect. Because GE is capable of suppressing a hyperactive liver and thus calming endogenous wind, and because Huntington's disease (HD) can be classified as a phenomenon of disturbed liver wind, it is suggested that GE might be beneficial in treating HD. However, although current studies support GE for the prevention of diverse neurodegenerations such as HD, its detailed mechanisms remain elusive. Read More

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http://dx.doi.org/10.1016/j.phymed.2018.11.016DOI Listing
November 2018

Idiopathic anaphylaxis.

Clin Exp Allergy 2019 Apr 19. Epub 2019 Apr 19.

Department of Allergy and Immunology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.

Idiopathic anaphylaxis (IA) or spontaneous anaphylaxis is a diagnosis of exclusion when no cause can be identified. The exact incidence and prevalence of IA is not known. The clinical manifestations of IA are similar to other known causes of anaphylaxis. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/cea.13402
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http://dx.doi.org/10.1111/cea.13402DOI Listing
April 2019
1 Read

Adrenal Morphology and Associated Comorbidities in Congenital Adrenal Hyperplasia.

Clin Endocrinol (Oxf) 2019 Apr 18. Epub 2019 Apr 18.

The National Institutes of Health Clinical Center, Bethesda, Maryland, 20892.

Objective: Adrenonodular hyperplasia and tumor formation are potential long-term complications of congenital adrenal hyperplasia (CAH) with little known regarding the clinical implications. Our aim was to describe volumetric adrenal morphology and determine the association between radiological findings and comorbidities in adults with classic CAH.

Design: This was a cross-sectional study of 88 patients (mean age 29. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/cen.13996
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http://dx.doi.org/10.1111/cen.13996DOI Listing
April 2019
1 Read

A Previously Unrecognized Monocytic Component of Pheochromocytoma and Paraganglioma.

Endocr Pathol 2019 Apr 18. Epub 2019 Apr 18.

Department of Pathology and Laboratory Medicine, Tufts Medical Center, 800 Washington Street, Box 802, Boston, MA, 02111, USA.

We describe a consistently present, previously unrecognized, population of monocytes in pheochromocytomas and paragangliomas. Although sustentacular cells are generally recognized as a common component of these tumors, differential immunohistochemical staining for CD163 and S100 shows that monocytes can in fact be more numerous. These cells frequently resemble sustentacular cells topographically and cytologically, possibly explaining why they have not been previously noticed. Read More

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http://dx.doi.org/10.1007/s12022-019-9575-6DOI Listing

Paraganglioma presenting as stress cardiomyopathy: case report and literature review.

Endocrinol Diabetes Metab Case Rep 2019 Apr 16;2019. Epub 2019 Apr 16.

Endocrinology and Diabetes Department, Garcia de Orta Hospital, Almada, Portugal.

Pheochromocytoma/paraganglioma (PPGL) are neuroendocrine tumors that can secrete catecholamines. The authors describe a challenging case who presented as stress cardiomyopathy and myocardial infarction (MI). A 76-year-old man, with a medical history of Parkinson's disease, type 2 diabetes mellitus, hypertension, dyslipidaemia and a previous inferior MI in 2001, presented to the emergency department due to chest pain, headaches and vomiting. Read More

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https://edm.bioscientifica.com/view/journals/edm/2019/1/EDM1
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http://dx.doi.org/10.1530/EDM-19-0017DOI Listing
April 2019
2 Reads

Correction: Prognostic Factors of Malignant Pheochromocytoma and Paraganglioma: A Combined SEER and TCGA Databases Review.

Horm Metab Res 2019 Apr 15. Epub 2019 Apr 15.

Department of Hematology and Oncology, Virginia Commonwealth University, Richmond, Virginia, USA.

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http://dx.doi.org/10.1055/a-0887-1201DOI Listing
April 2019
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The role of 68Ga-DOTA-Octreotate (GaTate) PET/CT in follow-up of SDH-associated pheochromocytoma and paraganglioma (PPGL).

J Clin Endocrinol Metab 2019 Apr 12. Epub 2019 Apr 12.

Centre for Cancer Imaging, Peter MacCallum Cancer Centre, Victoria, Australia.

Purpose: Germline succinate dehydrogenase (SDHx) mutation carriers, especially SDHB, are at increased malignancy risk and require life-long surveillance. Current guidelines recommend periodic whole-body MRI imaging. We assessed the incremental value of GaTate PET/CT compared to conventional imaging in such patients. Read More

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http://dx.doi.org/10.1210/jc.2019-00018DOI Listing
April 2019
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Clinical implications of the oncometabolite succinate in SDHx-mutation carriers.

Clin Genet 2019 Apr 12. Epub 2019 Apr 12.

Department of Endocrinology and Metabolic Diseases, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Succinate dehydrogenase (SDH) mutations lead to the accumulation of succinate, which acts as an oncometabolite. Germline SDHx mutations predispose to paraganglioma (PGL) and pheochromocytoma (PCC), as well as to renal cell carcinoma and gastro-intestinal stromal tumors. The SDHx genes were the first tumor suppressor genes discovered which encode for a mitochondrial enzyme, thereby supporting Otto Warburg's hypothesis in 1926 that a direct link existed between mitochondrial dysfunction and cancer. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/cge.13553
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http://dx.doi.org/10.1111/cge.13553DOI Listing
April 2019
4 Reads

Generation of Neural Crest Progenitors from Human Pluripotent Stem Cells.

Methods Mol Biol 2019 ;1976:37-47

Department of Biomedical Engineering, Centre for Neural Engineering, University of Melbourne, Parkville, VIC, Australia.

There are a vast range of diseases and disorders that are neurocristopathic in origin, including Hirschsprung's disease, pheochromocytoma, familial dysautonomia, craniofacial disorders, and melanomas. Having a source of human neural crest cells is highly valuable for investigating potential treatments for such diseases. This chapter describes a robust and well-characterized protocol for deriving neural crest from human pluripotent stem cells (hPSCs), which can then be differentiated to neuronal and non-neuronal lineages. Read More

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http://link.springer.com/10.1007/978-1-4939-9412-0_3
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http://dx.doi.org/10.1007/978-1-4939-9412-0_3DOI Listing
January 2019
2 Reads

The determination of real fluid requirements in laparoscopic resection of pheochromocytoma using minimally invasive hemodynamic monitoring: a prospectively designed trial.

Surg Endosc 2019 Apr 11. Epub 2019 Apr 11.

Division of General Surgery, Section Endocrine Surgery, Department of Surgery, Medical University of Vienna, Vienna, Austria.

Background: Hemodynamic instability is frequently observed during adrenalectomy for pheochromocytoma (PCC). Guidelines recommend liberal preoperative volume administration. However, it is unclear whether fluid deficiency or vasoplegia causes shifting hemodynamics and whether minimally invasive hemodynamic monitoring with esophageal Doppler (EDM) can help visualize intraoperative changes avoiding volume overload and complications. Read More

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http://dx.doi.org/10.1007/s00464-019-06777-zDOI Listing
April 2019
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High concentration of plasma methoxytyramine: dopamine-producing tumour or Parkinson's disease therapy?

Ann Clin Biochem 2019 Apr 11:4563219835263. Epub 2019 Apr 11.

1 Service of Clinical Pharmacology, University Hospital of Lausanne (CHUV), Lausanne, Switzerland.

Background: Levodopa (L-DOPA) provided to patients with Parkinson's disease causes an increase in dopamine and methoxytyramine blood concentration which may lead to erroneous diagnosis of dopamine-producing tumours based on a plasma fractionated metanephrines and methoxytyramine assay. Considering that oral L-DOPA is mainly transformed in the gut wall into dopamine and methoxytyramine, we hypothesize that patients treated with L-DOPA produce predominantly sulphated methoxytyramine, whereas dopamine-producing tumours, devoid of sulfotransferase, will secrete free methoxytyramine. These metabolic differences may allow for discrimination between the two groups of patients through methoxytyramine plasma concentration. Read More

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http://dx.doi.org/10.1177/0004563219835263DOI Listing
April 2019
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Neuroblastoma in Adolescents and Children Older than 10 Years: Unusual Clinicopathologic and Biological Features.

J Pediatr Hematol Oncol 2019 Apr 9. Epub 2019 Apr 9.

Department of Pathology, Children's Mercy Hospital/University of Missouri Kansas City School of Medicine, Kansas City, MO.

Neuroblastoma (NB) in children older than 10 years is rare. We reviewed our archives for patients with NB aged 10 to 18 years and summarized their clinicopathologic/genetic records. Of 96 patients, 4 patients were identified in this age group. Read More

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http://dx.doi.org/10.1097/MPH.0000000000001485DOI Listing
April 2019
1 Read

Evaluation of bone health in patients with adrenal tumors.

Curr Opin Endocrinol Diabetes Obes 2019 Apr 9. Epub 2019 Apr 9.

Division of Endocrinology, Metabolism and Nutrition, Mayo Clinic, Rochester, Minnesota, USA.

Purpose Of Review: Adrenal tumors occur in 5% of population with higher prevalence in elderly. Patients with adrenal tumors present with overt hormonal excess in up to 15% of cases, and mild autonomous cortisol secretion in 30-40% of cases. Overt Cushing syndrome, mild autonomous cortisol secretion, pheochromocytoma, and primary aldosteronism have been associated with higher cardiovascular morbidity and mortality. Read More

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http://dx.doi.org/10.1097/MED.0000000000000478DOI Listing
April 2019
1 Read

Ropivacaine mesylate exerts neurotoxicity via up-regulation of Fas/FasL expression in rat pheochromocytoma PC12 cells.

Am J Transl Res 2019 15;11(3):1626-1634. Epub 2019 Mar 15.

Department of Anesthesiology, The First People's Hospital of Xiangyang, Hubei University of Medicine Xiangyang 441000, Hubei Province, China.

It has been shown that local anesthetics have potential neurotoxicity, but the exact mechanism remains unclear. In this study, PC12 cells were treated with different concentrations of ropivacaine mesylate (0.1, 0. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456514PMC
March 2019
1 Read

Adrenal masses in children: Imaging, surgical treatment and outcome.

Asian J Surg 2019 Apr 5. Epub 2019 Apr 5.

Department of Pediatric Surgery, Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa, Turkey.

Background/objective: This study aims to evaluate the current surgical approach to adrenal masses in the pediatric age group.

Methods: We retrospectively analyzed cases that underwent surgery for adrenal masses between 2007 and 2017. Patients were assessed regarding age, sex, primary diagnosis, image defined risk factors (IDRF), surgical treatment method, complications, duration of hospital stay, and follow-up. Read More

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http://dx.doi.org/10.1016/j.asjsur.2019.03.012DOI Listing
April 2019
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FGF21 Levels in Pheochromocytoma/Functional Paraganglioma.

Cancers (Basel) 2019 Apr 5;11(4). Epub 2019 Apr 5.

Third Department of Medicine, Department of Endocrinology and Metabolism of the First Faculty of Medicine, Charles University and General University Hospital in Prague, 128 00 Prague, Czech Republic.

Fibroblast growth factor 21 (FGF21) is a hepatokine with beneficial effects on metabolism. Our aim was to evaluate the relationship between the serum FGF21, and energy and glucose metabolism in 40 patients with pheochromocytoma/functional paraganglioma (PPGL), in comparison with 21 obese patients and 26 lean healthy controls. 27 patients with PPGL were examined one year after tumor removal. Read More

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https://www.mdpi.com/2072-6694/11/4/485
Publisher Site
http://dx.doi.org/10.3390/cancers11040485DOI Listing
April 2019
2 Reads

3T MRI evaluation of regional catecholamine-producing tumor-induced myocardial injury.

Endocr Connect 2019 Mar 1. Epub 2019 Mar 1.

K Takase, Radiology, Tohoku University Hospital, Sendai, Japan.

Objective: Regional differences in cardiac magnetic resonance, which can reveal catecholamine-induced myocardial injury in patients with pheochromocytoma, have not yet been assessed using 3T magnetic resonance imaging. We evaluated these differences using myocardial T1-mapping and strain analysis.

Design And Methods: We retrospectively reviewed 16 patients newly diagnosed with catecholamine-producing tumors (CPT group) and 16 patients with essential hypertension (EH group), who underwent cardiac magnetic resonance imaging between May 2016 and March 2018. Read More

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http://dx.doi.org/10.1530/EC-18-0553DOI Listing
March 2019
1 Read

Higher risk of phaeochromocytoma/paraganglioma (Phaeo-Pgl) in SDHD than SDHB carriers: an Australian cohort study.

Intern Med J 2019 Apr;49(4):529-532

Department of Endocrinology and Diabetes, St Vincent's Hospital Melbourne, Melbourne, Victoria, Australia.

Carriers of succinate dehydrogenase (SDHx) mutations are at risk of developing phaeochromocytomas, catecholamine secreting extra-adrenal paragangliomas and non-secretory head and neck paragangliomas and require lifelong surveillance. There is no current consensus on the optimal surveillance strategy. This study describes the outcomes of a cohort of 50 SDHx mutation carriers followed at a tertiary Australian hospital using a surveillance protocol involving annual clinical review with plasma/urine metanephrines and biennial magnetic resonance imaging from skull base to pelvis. Read More

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http://dx.doi.org/10.1111/imj.14250DOI Listing
April 2019
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Pheochromocytoma and sinus node dysfunction.

Proc (Bayl Univ Med Cent) 2019 Jan 15;32(1):119-120. Epub 2019 Mar 15.

Department of Cardiovascular Medicine, Baylor Scott & White Medical Center-TempleTempleTexas.

Pheochromocytomas are rare catecholamine-producing neuroendocrine tumors that can lead to detrimental outcomes; if identified and treated, they are associated with a good prognosis. The clinical presentation can vary greatly but is classically associated with tachycardia, headaches, and hypertension. Bradyarrhythmias and sinus node dysfunction are uncommon complications of this condition. Read More

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http://dx.doi.org/10.1080/08998280.2018.1533310DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442887PMC
January 2019
1 Read

FAPI-PET/CT: Mean intensity of tracer-uptake (SUV) in 28 different kinds of cancer.

J Nucl Med 2019 Apr 6. Epub 2019 Apr 6.

University Hospital Heidelberg, Germany.

The recent development of quinoline based positron-emission-tomography (PET)-tracers that act as fibroblast-activation-protein inhibitors (FAPIs) demonstrated promising preclinical and clinical results. FAP is overexpressed by cancer associated fibroblasts (CAFs) of several tumor entities. Here we quantify the tumor-uptake in FAPI-PET/CT of various primary and metastatic tumors to identify the most promising indications for future application. Read More

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http://dx.doi.org/10.2967/jnumed.119.227967DOI Listing
April 2019
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Reversing ROS-mediated neurotoxicity by chlorogenic acid involves its direct antioxidant activity and activation of Nrf2-ARE signaling pathway.

Biofactors 2019 Apr 5. Epub 2019 Apr 5.

State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, China.

Chlorogenic acid (CA), the ester of caffeic acid and quinic acid, is one of the most abundant polyphenols in coffee, and has multiple pharmacological functions. The present study is designed to explore the protection provided by CA against hydrogen peroxide (H O )-induced oxidative damages in the rat pheochromocytoma cells, and the underlying mechanisms engaged in this process. CA displays robust free radical-scavenging activity in vitro. Read More

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http://dx.doi.org/10.1002/biof.1507DOI Listing
April 2019
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Translating metabolomic analysis of succinate dehydrogenase deficient tumours into clinical utility.

JCO Precis Oncol 2018 Mar;2:1-12

Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK.

Purpose: Mutations in the mitochondrial enzyme succinate dehydrogenase (SDH) subunit genes are associated with a wide spectrum of tumours including phaeochromocytoma and paraganglioma (PPGL) 1, 2, gastrointestinal stromal tumours (GIST) 3, renal cell carcinoma (RCC) 4 and pituitary adenomas5. SDH-related tumorigenesis is believed to be secondary to accumulation of the oncometabolite succinate. Our aim was to investigate the potential clinical applications of MRI spectroscopy (H-MRS) in a range of suspected SDH-related tumours. Read More

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http://ascopubs.org/doi/10.1200/PO.17.00191
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http://dx.doi.org/10.1200/PO.17.00191DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445359PMC
March 2018
7 Reads

A synonymous VHL variant in exon 2 confers susceptibility to familial pheochromocytoma and von Hippel-Lindau disease.

J Clin Endocrinol Metab 2019 Apr 4. Epub 2019 Apr 4.

Division of Hematology and Medical Oncology, Department of Medicine, Mays Cancer Center, UT Health San Antonio, San Antonio, TX, USA.

Context: von Hippel-Lindau disease, comprising renal cancer, hemangioblastoma and/or pheochromocytoma (PHEO) is caused by missense or truncating variants of the VHL tumor suppressor gene, which is involved in degradation of hypoxia inducible factors (HIFs). However, the role of synonymous VHL variants in the disease is unclear.

Objective: We evaluated a synonymous VHL variant in patients with familial PHEO or VHL disease without a detectable pathogenic VHL mutation. Read More

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http://dx.doi.org/10.1210/jc.2019-00235DOI Listing
April 2019
2 Reads

[Surgical treatment of neurofibromatosis type I followed by retroperitoneal tumor (in Russian only)].

Khirurgiia (Mosk) 2019 (3):5-14

Vishnevsky National Medical Research Center of Surgery, Moscow, Russia.

Aim: To determine the optimal surgical approach in patients with abdominal and retroperitoneal manifestations of Recklinghausen's disease.

Material And Methods: There were 4 patients (3 women and 1 man) with neurofibromatosis type I who were treated at Vishnevsky National Medical Research Center of Surgery.

Results: There were 3 robot-assisted procedures: excision of retroperitoneal tumors (plexiform neurofibroma and schwannoma) in 2 cases and right adrenal pheochromocytoma in 1 patient. Read More

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http://www.mediasphera.ru/issues/khirurgiya-zhurnal-im-n-i-p
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http://dx.doi.org/10.17116/hirurgia20190315DOI Listing
January 2019
2 Reads

Surgical therapy of adrenal tumors: guidelines from the German Association of Endocrine Surgeons (CAEK).

Langenbecks Arch Surg 2019 Apr 1. Epub 2019 Apr 1.

Universitätsklinikum Marburg, Marburg, Germany.

Background And Aims: Previous guidelines addressing surgery of adrenal tumors required actualization in adaption of developments in the area. The present guideline aims to provide practical and qualified recommendations on an evidence-based level reviewing the prevalent literature for the surgical therapy of adrenal tumors referring to patients of all age groups in operative medicine who require adrenal surgery. It primarily addresses general and visceral surgeons but offers information for all medical doctors related to conservative, ambulatory or inpatient care, rehabilitation, and general practice as well as pediatrics. Read More

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http://dx.doi.org/10.1007/s00423-019-01768-zDOI Listing
April 2019
1 Read

Diffusion-weighted imaging (DWI) highlights SDHB-related tumours: A pilot study.

Clin Endocrinol (Oxf) 2019 Apr 1. Epub 2019 Apr 1.

Department of Endocrinology, St Bartholomew's Hospital, Barts Health NHS Trust, London, UK.

Objective: There is consensus that asymptomatic carriers of SDHB mutations should undergo periodic surveillance imaging. MRI has the advantage of avoiding radiation exposure but its sensitivity and specificity for detecting phaeochromocytoma and paraganglioma (PPGL) are dependent on sequences performed and expertise of reporting radiologists. We aim to highlight the additional value of diffusion-weighted imaging (DWI) for MR based surveillance, demonstrating DWI's ability to identify small PPGLs at all body sites. Read More

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http://dx.doi.org/10.1111/cen.13980DOI Listing
April 2019
2 Reads

Recurrent Germline DLST Mutations in Individuals with Multiple Pheochromocytomas and Paragangliomas.

Am J Hum Genet 2019 Apr 28;104(4):651-664. Epub 2019 Mar 28.

Hereditary Endocrine Cancer Group, Spanish National Cancer Research Centre, Madrid, Madrid 28029, Spain; Centro de Investigación Biomédica en Red de Enfermedades Raras, Madrid, Madrid 28029, Spain. Electronic address:

Pheochromocytomas and paragangliomas (PPGLs) provide some of the clearest genetic evidence for the critical role of metabolism in the tumorigenesis process. Approximately 40% of PPGLs are caused by driver germline mutations in 16 known susceptibility genes, and approximately half of these genes encode members of the tricarboxylic acid (TCA) cycle. Taking as a starting point the involvement of the TCA cycle in PPGL development, we aimed to identify unreported mutations that occurred in genes involved in this key metabolic pathway and that could explain the phenotypes of additional individuals who lack mutations in known susceptibility genes. Read More

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http://dx.doi.org/10.1016/j.ajhg.2019.02.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451733PMC
April 2019
1 Read

Rare Case of Pheochromocytoma in a Young Female.

J Coll Physicians Surg Pak 2019 Apr;29(4):398-399

Department of Internal Medicine, Nishtar Hospital, Multan, Pakistan.

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http://dx.doi.org/10.29271/jcpsp.2019.04.398DOI Listing
April 2019
2 Reads

Pheochromocytomas and Paragangliomas: From Genetic Diversity to Targeted Therapies.

Cancers (Basel) 2019 Mar 28;11(4). Epub 2019 Mar 28.

Neuro-Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA.

Pheochromocytoma and paraganglioma (PCPGs) are rare neuroendocrine tumors that arise from the chromaffin tissue of adrenal medulla and sympathetic ganglia. Although metastatic PCPGs account for only 10% of clinical cases, morbidity and mortality are high because of the uncontrollable mass effect and catecholamine level generated by these tumors. Despite our expanding knowledge of PCPG genetics, the clinical options to effectively suppress PCPG progression remain limited. Read More

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http://dx.doi.org/10.3390/cancers11040436DOI Listing
March 2019
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Pheochromocytoma: 20 years of improving surgical care.

Am J Surg 2019 May 19;217(5):967-969. Epub 2019 Mar 19.

Department of Surgery, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Mail Code L223A, Portland, OR, 97239, USA. Electronic address:

Background: Laparoscopic adrenalectomy is now the standard for pheochromocytoma. We report two decades of institutional experience with pheochromocytoma adrenalectomy.

Methods: A retrospective review was undertaken of pheochromocytoma adrenalectomy patients between 1997 and 2017. Read More

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http://dx.doi.org/10.1016/j.amjsurg.2019.03.016DOI Listing
May 2019
1 Read

Nephrogenic diabetes insipidus after esophagectomy in a patient with remote history of lithium treatment: A case report.

Int J Surg Case Rep 2019 Mar 19;57:71-73. Epub 2019 Mar 19.

Department of Internal Medicine, Division of Nephrology and Hypertension, Henry Ford Hospital, Detroit, MI, USA.

Introduction: Nephrogenic diabetes insipidus occurs in patients on chronic lithium treatment even after lithium discontinuation. Patients affected by this disorder are highly vulnerable to hypernatremia when they cannot respond to their thirst mechanism. We report a rare case of hypernatremia due to undiagnosed nephrogenic diabetes insipidus post esophagectomy in a patient with remote history of lithium use. Read More

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http://dx.doi.org/10.1016/j.ijscr.2019.03.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438906PMC
March 2019
1 Read

Prognostic Factors of Malignant Pheochromocytoma and Paraganglioma: A Combined SEER and TCGA Databases Review.

Horm Metab Res 2019 Mar 27. Epub 2019 Mar 27.

Department of Hematology and Oncology, Virginia Commonwealth University, Richmond, Virginia, USA.

Pheochromocytoma (PCC) and paraganglioma (PGL) are rare malignancies while pathogenesis is strongly influenced by genetics. The prognostic factors of these patients remain poorly defined. We aim to study the epidemiology and survival pattern by analyzing the combination of SEER and Cancer Genome Atlas (TCGA) database. Read More

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http://dx.doi.org/10.1055/a-0851-3275DOI Listing
March 2019
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SYMPATHETIC PARAGANGLIOMA: A SINGLE-CENTER EXPERIENCE FROM WESTERN INDIA.

Endocr Pract 2019 Mar;25(3):211-219

Objective: Most of the Indian studies on pheochromocytoma/paraganglioma (PCC/PGL) have focused on PCC, and there is a paucity of information regarding sympathetic paraganglioma (sPGL). Here, we describe the clinical, biochemical, and imaging features of sPGL compared with PCC.

Methods: This retrospective study included 75 patients with sPGL and 150 patients with PCC. Read More

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http://dx.doi.org/10.4158/EP-2018-0480DOI Listing
March 2019
8 Reads

Contributions of Mass Spectrometry to the Identification of Low Molecular Weight Molecules Able to Reduce the Toxicity of Amyloid-β Peptide to Cell Cultures and Transgenic Mouse Models of Alzheimer's Disease.

Molecules 2019 Mar 24;24(6). Epub 2019 Mar 24.

Center for Advanced Research and Development in Experimental Medicine (CEMEX), "Grigore T. Popa" University of Medicine and Pharmacy, 16 Universității Street, 700115 Iaşi, Romania.

Alzheimer's Disease affects approximately 33 million people worldwide and is characterized by progressive loss of memory at the cognitive level. The formation of toxic amyloid oligomers, extracellular amyloid plaques and amyloid angiopathy in brain by amyloid beta peptides are considered a part of the identified mechanism involved in disease pathogenesis. The optimal treatment approach leads toward finding a chemical compound able to form a noncovalent complex with the amyloid peptide thus blocking the process of amyloid aggregation. Read More

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http://dx.doi.org/10.3390/molecules24061167DOI Listing
March 2019
2 Reads

Preliminary Study on Clusterin Protein (sCLU) Expression in PC-12 Cells Overexpressing Wild-Type and Mutated (Swedish) genes Affected by Non-Steroid Isoprenoids and Water-Soluble Cholesterol.

Int J Mol Sci 2019 Mar 24;20(6). Epub 2019 Mar 24.

Department of Physiological Sciences, Faculty of Veterinary Medicine, Warsaw University of Life Sciences ⁻ SGGW, Nowoursynowska 159, 02-776 Warsaw, Poland.

In this study we attempted to verify the hypothesis that the mevalonate pathway affects amyloid beta precursor protein (AβPP) processing and regulates clusterin protein levels. expression was monitored by green fluorescence (FL) and Western blot (WB). WB showed soluble amyloid protein precursor alpha (sAβPPα) presence in -wt cells and Aβ expression in -sw cells. Read More

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https://www.mdpi.com/1422-0067/20/6/1481
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http://dx.doi.org/10.3390/ijms20061481DOI Listing
March 2019
8 Reads

Double trouble: two cases of dual adrenal pathologies in one adrenal mass.

Endocrinol Diabetes Metab Case Rep 2019 Mar 23;2019. Epub 2019 Mar 23.

St. Vincent's University Hospital and University College Dublin, Dublin, Ireland.

Context Adrenal incidentalomas (AI) represent an increasingly common problem in modern endocrine practice. The diagnostic approach to AIs can be challenging and occasionally reveals surprising features. Here we describe two rare cases of complex adrenal lesions consisting of phaeochromocytomas with synchronous metastases from extra-adrenal primaries. Read More

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http://dx.doi.org/10.1530/EDM-18-0151DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6432979PMC
March 2019
1 Read

Pheochromocytoma triggers takotsubo syndrome.

Eur Heart J 2019 Mar 21. Epub 2019 Mar 21.

Department of Cardiology, University Hospital Zurich, Zurich, Switzerland.

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http://dx.doi.org/10.1093/eurheartj/ehz084DOI Listing
March 2019
1 Read

Adrenal adenoma in von Hippel-Lindau syndrome: A case report with review of literature.

J Cancer Res Ther 2019 Mar;15(Supplement):S163-S166

Department of Pathology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.

A 29-year-old hypertensive male with von Hippel-Lindau (VHL) syndrome came to the Endocrinology department for evaluation. Contrast-enhanced computed tomography of the abdomen revealed an adrenal mass, bilateral renal cell carcinoma, and multiple pancreatic cysts. The hormonal investigations for adrenal mass were normal. Read More

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http://dx.doi.org/10.4103/jcrt.JCRT_127_18DOI Listing
March 2019
2 Reads

Bidirectional ventricular tachycardia in ACTH-producing pheochromocytoma.

Europace 2019 Mar 20. Epub 2019 Mar 20.

Department of Endocrinology, Hospital de Braga, Braga, Portugal.

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http://dx.doi.org/10.1093/europace/euz043DOI Listing
March 2019
2 Reads

Genotype-phenotype correlations in pheochromocytoma and paraganglioma.

Endocr Relat Cancer 2019 Mar 1. Epub 2019 Mar 1.

K Pacak, NICHD, NIH, Bethesda, 20817, United States.

Pheochromocytoma and paraganglioma (PPGL) can be divided into at least four molecular subgroups. Whether such categorizations are independent factors for prognosis or metastatic disease is unknown. We performed a systematic review and individual patient meta-analysis aiming to estimate if driver mutation status can predict metastatic disease and survival. Read More

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http://dx.doi.org/10.1530/ERC-19-0024DOI Listing
March 2019
3 Reads

Metastatic pheochromocytoma and paraganglioma: recent advances in prognosis and management.

Authors:
Oksana Hamidi

Curr Opin Endocrinol Diabetes Obes 2019 Mar 18. Epub 2019 Mar 18.

Division of Endocrinology and Metabolism, University of Texas Southwestern Medical Center, Dallas, Texas, USA.

Purpose Of Review: Metastatic pheochromocytomas and paragangliomas (PPGL) are rare neuroendocrine tumors with variable prognosis. This review highlights recent studies on outcomes and management of patients with metastatic PPGL.

Recent Findings: Latest advances were made in identifying predictors of favorable outcomes of patients with metastatic PPGL. Read More

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http://dx.doi.org/10.1097/MED.0000000000000476DOI Listing
March 2019
3 Reads

The Investigation into the Toxic Potential of Iron Oxide Nanoparticles Utilizing Rat Pheochromocytoma and Human Neural Stem Cells.

Nanomaterials (Basel) 2019 Mar 18;9(3). Epub 2019 Mar 18.

Department of Bioengineering, College of Engineering, Temple University, Philadelphia, PA 19122, USA.

Magnetic iron oxide (Magnetite, Fe₃O₄) nanoparticles are widely utilized in magnetic resonance imaging (MRI) and drug delivery applications due to their superparamagnetism. Surface coatings are often employed to change the properties of the magnetite nanoparticles or to modulate their biological responses. In this study, magnetite nanoparticles were fabricated through hydrothermal synthesis. Read More

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http://dx.doi.org/10.3390/nano9030453DOI Listing
March 2019
5 Reads

Morphometric and computational assessments to evaluate neuron survival and maturation within compartmentalized microfluidic devices: The influence of design variation on diffusion-driven nutrient transport.

Neurosci Lett 2019 Mar 15;703:58-67. Epub 2019 Mar 15.

Biomedical Engineering, College of Engineering, University of Michigan, Ann Arbor, MI, 48109, USA; Material Science and Engineering, College of Engineering, University of Michigan, Ann Arbor, MI, 48109, USA; Macromolecular Science and Engineering, College of Engineering, University of Michigan, Ann Arbor, MI, 48109, USA. Electronic address:

Burgeoning use of segregated microfluidic platforms that parse somas and neurites into discrete compartments is fueling unique examinations of neuronal structure and physiology in a manner impossible to achieve with non-compartmentalized systems. However, even though this line of axon-soma polarizing microfluidic devices stems from the same general design of a Campenot chamber set-up, slight deviations in device geometry appear to induce vastly different nutrient transport profiles that influence neuron survival and maturation. Here we examine the uptake of nerve growth factor (NGF) by a pheochromocytoma PC12 cell line cultured using two Campenot-like device designs, a "Standard" layout, representative of a commercial device, and a custom "Notch" layout, predicted to encourage more efficient nutrient transfer that gives rise to sustained neuron viability and extensive neurite elaboration. Read More

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http://dx.doi.org/10.1016/j.neulet.2019.03.025DOI Listing
March 2019
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[The role of abnormal mitochondrial fusion and fission in PBDE-47-induced change in mitochondrial mass in PC12 cells].

Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2019 Jan;37(1):1-6

MOE Key Lab of Environment and Health, Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.

To investigate the effect of 2, 2', 4, 4'-tetrabromodiphenyl ether (PBDE-47) on the mitochondrial mass in rat adrenal pheochromocytoma (PC12) cells and the potential mechanisms. Highly differentiated PC12 cells were divided into control, 1, 10 or 20 μmol/L PBDE-47-treated groups and cultured for 24 h. Transmission electron microscopy was employed to observe the changes in mitochondrial morphology and quantity in PC12 cells. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1001-9391.2019.01.001DOI Listing
January 2019
3 Reads

Posterior retroperitoneoscopic adrenalectomy for pediatric adrenal tumors.

J Pediatr Surg 2019 Feb 28. Epub 2019 Feb 28.

Department of Paediatric Surgery, KK Women's and Children's Hospital, 100 Bukit Timah Road, Singapore 229899. Electronic address:

Background/aims: Posterior retroperitoneoscoic adrenalectomy has been reported as an option for adrenal tumor resection but is not commonly performed in children owing to the extreme semikneeling position advocated to flatten the lumbar lordosis in order to achieve adequate retroperitoneal space. As children have smaller lordosis angles, flattening of the lordosis and creation of optimal retroperitoneal space may be achieved with less hip flexion. We used pediatric lumbar lordosis measurements to develop a modified prone jackknife position and report our experiences with this setup for posterior retroperitoneoscopic adrenalectomy for adrenal tumors. Read More

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http://dx.doi.org/10.1016/j.jpedsurg.2019.01.068DOI Listing
February 2019
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Targeted next-generation sequencing detects rare genetic events in pheochromocytoma and paraganglioma.

J Med Genet 2019 Mar 15. Epub 2019 Mar 15.

Genetics department, Assistance Publique-Hôpitaux de Paris, Hôpitaleuropéen Georges Pompidou, F-75015, Paris, France.

Background: Knowing the genetic status of patients affected by paragangliomas and pheochromocytomas (PPGL) is important for the guidance of their management and their relatives. Our objective was to improve the diagnostic performances of PPGL genetic testing by next-generation sequencing (NGS).

Methods: We developed a custom multigene panel, which includes 17 PPGL genes and is compatible with both germline and tumour DNA screening. Read More

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http://dx.doi.org/10.1136/jmedgenet-2018-105714DOI Listing
March 2019
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6.335 Impact Factor

Membrane-Associated, Not Cytoplasmic or Nuclear, FGFR1 Induces Neuronal Differentiation.

Cells 2019 Mar 14;8(3). Epub 2019 Mar 14.

Division of Neuroanatomy, Medical University of Innsbruck, 6020 Innsbruck, Austria.

The intracellular transport of receptor tyrosine kinases results in the differential activation of various signaling pathways. In this study, optogenetic stimulation of fibroblast growth factor receptor type 1 (FGFR1) was performed to study the effects of subcellular targeting of receptor kinases on signaling and neurite outgrowth. The catalytic domain of FGFR1 fused to the algal light-oxygen-voltage-sensing (LOV) domain was directed to different cellular compartments (plasma membrane, cytoplasm and nucleus) in human embryonic kidney (HEK293) and pheochromocytoma (PC12) cells. Read More

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https://www.mdpi.com/2073-4409/8/3/243
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http://dx.doi.org/10.3390/cells8030243DOI Listing
March 2019
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Catecholamine and Metanephrine Levels in Breast Milk Before and After Paraganglioma Resection.

Breastfeed Med 2019 Mar 15. Epub 2019 Mar 15.

1 Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, Minnesota.

Background: Catecholamine and metanephrine transfer into breast milk in the setting of secreting paraganglioma or pheochromocytoma has not been previously described.

Materials And Methods: We present an investigation in which we measured catecholamine and metanephrine levels in the breast milk in a single patient undergoing resection of a paraganglioma at 5 weeks postpartum.

Results: As expected, levels were elevated preoperatively and decreased rapidly after resection. Read More

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http://dx.doi.org/10.1089/bfm.2019.0018DOI Listing
March 2019
1 Read