Speed of processing and executive functions in adults with phenylketonuria: Quick in finding the word, but not the ladybird.
Cogn Neuropsychol 2017 Jun 20:1-28. Epub 2017 Jun 20.
a School of Life and Health Sciences , Aston University , Birmingham , UK.
A reduction in processing speed is widely reported in phenylketonuria (PKU), possibly due to white matter pathology. We investigated possible deficits and their relationships with executive functions in a sample of 37 early-treated adults with PKU (AwPKUs). AwPKUs were not characterized by a generalized speed deficit, but instead their performance could be explained by two more specific impairments: (a) a deficit in the allocation of visuo-spatial attention that reduced speed in visual search tasks, in some reading conditions and visuo-motor coordination tasks; and (b) a more conservative decision mechanism that slowed down returning an answer across domains. Read More