71 results match your criteria Pharyngoconjunctival Fever
Int J Infect Dis 2018 Oct 23;75:89-91. Epub 2018 Aug 23.
Beijing Center for Disease Prevention and Control, No. 16 Hepingli Middle Road, Beijing 100013, People's Republic of China; Research Center for Preventive Medicine of Beijing, No. 16 Hepingli Middle Road, Beijing 100013, People's Republic of China. Electronic address:
Patients with swimming pool-acquired human adenovirus (HAdV) infections usually manifest characteristic clinical features that include fever, pharyngitis, and conjunctival inflammation, syndromically referred to as pharyngoconjunctival fever (PCF). HAdV types 3, 4, and 7 are most commonly associated with PCF. This article reports an outbreak of PCF that involved 55 students and staff at a university in Beijing, China. Read More
Infect Drug Resist 2018 17;11:981-993. Epub 2018 Jul 17.
Pennsylvania College of Optometry, Salus University, Elkins Park, PA, USA,
Human adenovirus (HAdV) is a ubiquitous virus that infects the mucosa of the eye. It is the most common cause of infectious conjunctivitis worldwide, affecting people of all ages and demographics. Pharyngoconjunctival fever outbreak is due to HAdV types 3, 4, and 7, whereas outbreaks of epidemic keratoconjunctivitis are usually caused by HAdV types 8, 19, 37, and 54. Read More
N Z Med J 2018 May 18;131(1475):77-80. Epub 2018 May 18.
Infectious Diseases Physician, Infectious Disease Department, Christchurch Hospital, Christchurch.
Eye Contact Lens 2018 Sep;44 Suppl 1:S1-S7
EVMS Department of Ophthalmology, Eastern Virginia Medical School (D.G.-Z.), Norfolk, VA; Department of Ophthalmology, Wills Eye Hospital (C.R.), Philadelphia, PA; Department of Ophthalmology, Eastern Virginia Medical School (J.D.S.), Virginia Eye Consultants, Norfolk, VA; and EVMS Department of Ophthalmology (A.R.D.).
Adenoviral conjunctivitis comprises a large number of physician office visits in the United States and places a great financial burden on health care. It is estimated that the incidence of adenovirus infection to be as high as 20 million cases per year in the United States. There are multiple adenovirus serotypes, each associated with different types and severity of infection. Read More
Korean J Pediatr 2018 Jan 22;61(1):12-16. Epub 2018 Jan 22.
Department of Pediatrics, Ewha Womans University School of Medicine, Seoul, Korea.
Purpose: To differentiate adenoviral pharyngoconjunctival fever (PCF) from acute Kawasaki disease (KD) using laboratory tests before results of virus-real time polymerase chain reaction and ophthalmologic examination are obtained.
Methods: Baseline patient characteristics and laboratory measurements were compared between 40 patients with adenovirus infection and 123 patients with KD.
Results: The patients with adenovirus infection were generally older than those with KD (median: 3. Read More
Epidemiol Infect 2016 06 6;144(8):1661-72. Epub 2016 Jan 6.
Department of Infectious Diseases,Zhejiang Provincial Center for Disease Control and Prevention,Hangzhou,Zhejiang Province,China.
This study aimed to compare the virology and epidemiology of epidemic keratoconjunctivitis (EKC), pharyngoconjunctival fever (PCF) and acute haemorrhagic conjunctivitis (AHC) outbreaks worldwide caused by the human adenovirus (HAdV) from 1953 to 2013. Eighty-three hexon sequences from 76 conjunctivitis outbreaks were analysed and subtyped using Mega 5.05, Clustal X and SimPlot software. Read More
J Infect Chemother 2015 Nov 25;21(11):776-82. Epub 2015 Aug 25.
School of Pharmacy, Nihon University, Chiba, Japan.
The incidence of common pediatric infectious diseases has been monitored officially at sentinel medical institutions in Japan. However, the numbers of affected patients are not provided. Prescription Surveillance (PS), which infers the number of patients with influenza, varicella, and gastrointestinal infections from data related to prescriptions at external pharmacies, provides estimates to the public the following morning. Read More
Surv Ophthalmol 2015 Sep-Oct;60(5):435-43. Epub 2015 May 5.
Centre for Eye Research Australia, University of Melbourne, Victoria, Australia; Vision Eye Institute, Royal Victorian Eye and Ear Hospital, North West Academic Centre, University of Melbourne, Victoria, Australia. Electronic address:
Viral conjunctivitis caused by adenovirus is the most common infectious conjunctivitis. Adenoviruses are highly contagious pathogens. The modes of transmission are mainly through hand to eye contact, ocular secretions, respiratory droplets, and contact with ophthalmic care providers and their medical instruments. Read More
Eur J Microbiol Immunol (Bp) 2014 Mar 14;4(1):26-33. Epub 2014 Mar 14.
The aim of this review is to describe the biology of human adenovirus (HAdV), the clinical and epidemiological characteristics of adenoviral epidemic keratoconjunctivitis and to present a practical update on its diagnosis, treatment, and prophylaxis. There are two well-defined adenoviral keratoconjunctivitis clinical syndromes: epidemic keratoconjunctivitis (EKC) and pharyngoconjunctival fever (PCF), which are caused by different HAdV serotypes. The exact incidence of adenoviral conjunctivitis is still poorly known. Read More
J Infect Chemother 2014 May 1;20(5):303-6. Epub 2014 Mar 1.
Laboratory of Molecular Epidemiology for Infectious Agents, Kitasato Institute for Life Sciences, Kitasato University, Tokyo, Japan; Department of Infectious Diseases, Keio University School of Medicine, Tokyo, Japan. Electronic address:
A new immunochromatographic (IC) assay kit, BD Veritor System Adeno was evaluated to comparing with commercial available kit, BD Adeno Examan, cell culture, and real-time PCR using throat swab samples. Specimens were collected from 146 pediatric patients between July 2011 and January 2012. Mean age of patients was 4 years (8 months-15 years old). Read More
Arch Soc Esp Oftalmol 2013 Mar 25;88(3):108-15. Epub 2012 Sep 25.
Servicio de Oftalmología, Hospital Universitario Ramón y Cajal, Madrid, Spain.
The objective of this review is to describe the clinical and epidemiological characteristics of adenoviral conjunctivitis, as well as to present a practical update on its diagnosis, treatment and prophylaxis. There are two well-defined adenoviral keratoconjunctivitis clinical syndromes: epidemic keratoconjunctivitis and pharyngoconjunctival fever, which are caused by different adenovirus serotypes. The exact incidence of adenoviral conjunctivitis is unknown. Read More
Jpn J Infect Dis 2012 ;65(5):457-9
Hyogo Prefectural Institute of Public Health and Consumer Sciences, Hyogo, Japan.
PLoS One 2012 27;7(7):e42261. Epub 2012 Jul 27.
Department of Biostatistics, Faculty of Medicine, Oita University, Yufu, Oita, Japan.
Background: To prevent and control infectious diseases, it is important to understand how sex and age influence morbidity rates, but consistent clear descriptions of differences in the reported incidence of infectious diseases in terms of sex and age are sparse.
Methods And Findings: Data from the Japanese surveillance system for infectious diseases from 2000 to 2009 were used in the analysis of seven viral and four bacterial infectious diseases with relatively large impact on the Japanese community. The male-to-female morbidity (MFM) ratios in different age groups were estimated to compare incidence rates of symptomatic reported infection between the sexes at different ages. Read More
J Clin Microbiol 2012 Jun 21;50(6):1879-88. Epub 2012 Mar 21.
Department of Infectious Diseases, Hangzhou Center for Disease Control and Prevention, Jianqiao Town, Hangzhou, Zhejiang Province, China.
Adenovirus serotype 3 and 7 outbreaks have occurred periodically in northern, eastern, and southern China since 1955, but there has been no report since the adenovirus serotype 7 outbreak first occurred in Hangzhou, China, in 1991. Here we explored the epidemiology and etiology of two adenovirus serotype 3 outbreaks in Hangzhou in 2011. One acute respiratory outbreak was found in Chun'an County, where a total of 371 cases were confirmed in 5 of 23 towns from 4 to 31 May 2011. Read More
J Fr Ophtalmol 2010 Oct 17;33(8):586-92. Epub 2010 Aug 17.
Service d'ophtalmologie, Hôtel-dieu, 1, place du Parvis-Notre-Dame, 75004 Paris, France.
Adenovirus keratoconjunctivitis is caused by numerous types of adenovirus with different clinical presentations. The most frequent is epidemic keratoconjunctivitis (EKC), but follicular conjunctivitis and pharyngoconjunctival fever are also possible. The virus is very resistant to desiccation and it is transmitted by direct contact. Read More
Arch Virol 2010 Feb 24;155(2):287-92. Epub 2009 Dec 24.
Department of Clinical Laboratory, Kaohsiung Medical University, Kaohsiung, Taiwan.
Genome type analysis of adenovirus type 3 (Ad3) in Taiwan identified four types (Ad3a, Ad3a2, Ad3a1, Ad3-7) during 1983-2005. Ad3a was the major type during 1983-1999, while Ad3a2 was the predominant type from 2001 to 2005. Phylogenetic analysis of the hexon gene of 23 isolates revealed that most Ad3a2 and Ad3-7 isolates belonged to one cluster, and most Ad3a isolates to the other cluster. Read More
Euro Surveill 2009 Feb 26;14(8). Epub 2009 Feb 26.
Epidemiology Unit, Basque Governement s Health Department, Gipuzkoa, Spain.
An outbreak of pharyngoconjunctival fever affecting 59 children was detected in a municipality of northern Spain in July 2008. The outbreak was related to insufficient doses of water disinfectant in the municipal swimming pool. Read More
J Epidemiol 2007 Dec;17 Suppl:S14-22
Department of Public Health, Saitama Medical University Faculty of Medicine, 38 Morohongo, Moroyama-machi, Iruma-gun Saitama 350-0495, Japan.
Background: A method for determining epidemics in small areas from the sentinel surveillance data has been proposed and applied in the National Epidemiological Surveillance of Infectious Diseases (NESID) in Japan. We observed epidemics of influenza and 11 pediatric diseases by the method in the NESID in Japan during 1999-2005.
Methods: We assumed that an epidemic in a public health center area began in a week when the number of cases reported to the NESID per sentinel clinic and hospital in the area in the week exceeded a given value, and that the epidemic ended when the number was lower than another given value. Read More
Eur J Pediatr 2008 Jun 18;167(6):633-40. Epub 2007 Sep 18.
Department of Pediatrics, National Taiwan University Hospital, College of Medicine, National Taiwan University, No 7. Chung-Shan South Road, Taipei, Taiwan, Republic of China.
This study clinically and molecularly characterizes an adenovirus epidemic that broke out in Taiwan in April 2004. Clinical data on 325 children diagnosed with acute illness were collected between April 2004 and April 2005, and a diagnosis of adenovirus was confirmed by viral isolation. Polymerase chain reaction and restriction fragment length polymorphism were used to identify the adenovirus genotypes in 267 patients. Read More
Nihon Rinsho 2007 Mar;65 Suppl 3:304-8
Department of Pediatrics, Sapporo Medical University School of Medicine.
Graefes Arch Clin Exp Ophthalmol 2006 Nov 21;244(11):1497-504. Epub 2006 Mar 21.
Bundeswehr Institute of Microbiology, Neuherbergstrasse 11, 80937 Munich, Germany.
Background: Human adenoviruses (HAdV) may cause pharyngoconjunctival fever, follicular conjunctivitis or epidemic keratoconjunctivitis (EKC). Especially, outbreaks of the latter may lead to severe economic losses when preventive measures are implemented too late. Thus, a safe sampling method, proper specimen transport conditions and a fast and sensitive diagnostic technique is mandatory. Read More
J Clin Microbiol 2004 Dec;42(12):5489-92
Infectious Disease Research Division, Hyogo Prefectural Institute of Public Health and Environmental Sciences, 2-1-29, Arata-Cho, Hyogo-Ku, Kobe 652-0032, Japan.
An immunochromatography (IC) kit for human adenovirus (HAdV) was evaluated with 138 patient nasopharyngeal samples. The samples were collected at a sentinel clinic in Japan from January through June 2003. Patients were diagnosed by clinical manifestation of pharyngoconjunctival fever (n = 38) or exudative tonsillitis (n = 100). Read More
J Trop Pediatr 2004 10;50(5):279-84
Department of Pediatrics, Kaohsiung Municipal Hsiaokang Hospital, Kaohsiung, Taiwan.
Adenoviruses account for 5-10 per cent of respiratory illnesses in children. To analyse the clinical features and the temporal frequency in acute adenoviral respiratory infections in hospitalized children in southern Taiwan, a total of 4333 children who were admitted to the Department of Pediatrics, Kaohsiung Municipal Hsiaokang (KMHK) Hospital, with clinical evidences of acute respiratory infections between January 2001 and December 2002 were studied. Adenoviruses were isolated from 317 patients with an isolation rate of 7. Read More
Commun Dis Intell 2001 Jan;25(1):9-12
Tropical Public Health Unit, PO Box 1103, Cairns, Qld, Australia 4870.
High rates of absenteeism in a North Queensland primary school, due to eye irritation, fever, headache, and stomach pain, were reported to the Tropical Public Health Unit in October 2000. Subsequent investigation demonstrated that the symptoms were due to adenovirus infection. Symptoms were consistent with a diagnosis of pharyngoconjunctival fever. Read More
Microbiol Immunol 2000 ;44(10):821-6
Division of Microbiology, Hyogo Prefectural Institute of Public Health, Kobe, Japan.
We developed a new diagnostic method of subgenus (Sub) B adenovirus (Ad) in clinical samples using non-nested polymerase chain reaction (PCR). Sequences of the conserved hexon-coding region of representative strains of eight serotypes (3, 7, 11, 14, 16, 21, 34 and 35) of Sub B Ad were heterogeneous. In order to distinguish Ad serotype 3 (Ad 3) and Ad 7 from the other serotypes of Sub B Ad, and to differentiate Ad 3 and 7 from each other, 3 different downstream primers were designed based on the sequence heterogeneity. Read More
Epidemiol Infect 2000 Oct;125(2):333-45
School of Medicine, The University of Manchester, UK.
Data relating to 3313 adenovirus isolates from patients in Greater Manchester, UK between 1982 and 1996 were analysed using chi2 tests and 95% confidence intervals. Of the 3098 isolates that were typed, 18.6% were serotype 2, 14. Read More
Ryoikibetsu Shokogun Shirizu 1999 (25 Pt 3):148-50
MMWR Morb Mortal Wkly Rep 1998 Jul;47(27):567-70
Adenoviruses are human pathogens that commonly infect the respiratory and gastrointestinal tracts. Adenovirus infections are endemic, particularly among children, but also may cause epidemics of pharyngoconjunctival fever, keratoconjunctivitis, gastroenteritis, and acute respiratory disease (ARD) among military trainees. Outbreaks of ARD among adults in the civilian sector are rare. Read More
J Infect 1996 Mar;32(2):113-7
Department of Pathological Sciences, University of Manchester, Manchester Royal Infirmary, UK.
Endemic (type 1, 2, 5 and 6) and epidemic (type 3, 4 and 7) respiratory adenovirus infections are associated with upper respiratory tract symptoms, pharyngoconjunctival fever, and pneumonia. Improved methods of diagnosis are needed, particularly in immunocompromized patients. We examined 93 throat swabs or nasopharyngeal aspirates from patients with acute respiratory disease using virus isolation and an adenovirus-specific polymerase chain reaction (PCR) based on consensus primers H1 and H2 derived from the hexon region DNA sequences of serotypes 2 and 5. Read More
Infect Control Hosp Epidemiol 1992 Aug;13(8):499-500
JAMA 1992 Jun;267(21):2867-8
MMWR Morb Mortal Wkly Rep 1992 May;41(19):342-4
On July 19, 1991, the Communicable Disease Section of the North Carolina Department of Environment, Health, and Natural Resources (DEHNR) was notified that an outbreak of acute upper respiratory illness had occurred in campers and counselors at a 4-week summer camp. Manifestations of the illness included pharyngitis, cough, fever to 104 F (40 C), headache, myalgia, malaise, and conjunctivitis. On August 2, the DEHNR was notified of a similar outbreak during a second 4-week session at the camp. Read More
Pediatr Infect Dis J 1992 Jan;11(1):6-9
Department of Pediatrics, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Among a group of hospitalized children in Fukuoka, southern Japan, an epidemic of pharyngoconjunctival fever-like disease caused by adenovirus type 11 was observed in the autumn of 1988. Of the 47 children studied 38 were seronegative in neutralizing antibody for adenovirus type 11 before the epidemic, and seroconversion occurred in 16 (42%) including 5 subclinical cases. Of the 11 symptomatic patients the incidences of conjunctivitis, pharyngitis and fever were 91, 64 and 46%, respectively. Read More
Intervirology 1991 ;32(6):338-50
Department of Virology, 302nd Hospital, Beijing, People's Republic of China.
Eleven genome types of adenovirus serotype 11 (Ad11) were identified among 20 strains isolated from healthy pregnant women and patients with urinary tract infections, respiratory tract infections, or pharyngoconjunctival fever by use of 13 restriction endonucleases: BamHI, BclI, BglI, BglII, BstEII, EcoRI, HindIII, HpaI, PstI, SalI, SmaI, XbaI, and XhoI. All genome types could be grouped into three genomic clusters according to their genetic homology expressed as pairwise comigrating restriction fragments. The genome types within a genomic cluster were very closely related. Read More
Nippon Ganka Gakkai Zasshi 1989 Aug;93(8):865-9
Adenoviral conjunctivitis is contagious and it should be diagnosed rapidly. Adenoviral ocular infection showed epidemic keratoconjunctivitis due to Ad8 and pharyngoconjunctival fever due to Ad3 but those clinical pictures are changing because of the appearance of new serotypes of adenovirus such as Ad4, 19 and 37 which are related with acute conjunctivitis. The diagnosis of viral infection is generally time consuming and complex. Read More
J Virol Methods 1989 Jun;24(3):307-12
Microbiology/Public Health Laboratory, Royal United Hospital, Combe Park, Bath, U.K.
A monoclonal antibody-based solid-phase immunoassay (ELISA) was used to detect adenovirus antigen in clinical specimens during an outbreak of pharyngoconjunctival fever at a boarding school. The use of the kit enabled rapid diagnosis of the cause of the outbreak. The assay was also valuable in confirmation of tissue culture isolation of adenovirus. Read More
J Med Virol 1988 Dec;26(4):453-9
Departamento de Virologia, Fundaçõ Oswaldo Cruz, Rio de Janeiro, Brazil.
An outbreak of pharyngoconjunctival fever caused by adenovirus (Ad) occurred in 1976 in Belem (northern Brazil). By restriction endonuclease analysis, it was shown that the type responsible was Ad4a, a variant of Ad4 prototype (Ad4p) and previously described as causative agent of ocular diseases. In an epidemiologic study carried out in Rio de Janeiro and Belem between 1977 and 1986, 148 Ads were isolated from children with respiratory disease. Read More
J Med Virol 1986 Mar;18(3):213-27
Genome analysis was performed on 125 adenovirus isolates from conjunctival swabs of patients with conjunctivitis obtained in Glasgow between 1981 and 1984. A summer outbreak in 1981 was mainly due to species 3 adenoviruses, of which genotype 3GB and five different genotypic variants cocirculated. Three species 3 variants were also observed in 1982. Read More
Arch Dis Child 1984 Dec;59(12):1182-3
Sixteen infants and toddlers from four kibbutz day nurseries contracted an illness comprising fever, conjunctivitis, respiratory infection, lymphadenopathy, otitis media, and a new sign, migratory palpebral erythema. Adenovirus type 3 was isolated from the pharynx of the first three children taken ill. Read More
J Hyg (Lond) 1984 Oct;93(2):277-83
An outbreak of pharyngoconjunctival fever caused by adenovirus type 3 was studied in a boarding school for 800 boys aged 11-18 years. A total of 96 clinical cases were confirmed by laboratory tests. Clinical infection rates were higher in the younger boys but total infection rate did not vary with age. Read More
J Am Optom Assoc 1983 Feb;54(2):141-4
The author reports an epidemic of adeno- and enteroviral eye infections at an overseas military complex in the third quarter of 1981. A similar epidemic was reported by the Center for Disease Control, Atlanta, GA to also have occurred in Florida, Latin America, and North Carolina at approximately the same time. The differential diagnosis between epidemic keratoconjunctivitis, pharyngoconjunctival fever, acute hemorrhage conjunctivitis and Chlamydial infections is described. Read More
J Hyg (Lond) 1981 Feb;86(1):95-103
A number of adenovirus serotypes have been associated with both sporadic cases and outbreaks of conjunctivitis and pharyngoconjunctival fever but only adenovirus type 8 and adenovirus type 19 have been responsible for wide-spread epidemic kerato-conjunctivitis. In Melbourne, Australia, in the past eight years these two serotypes have been prevalent, resulting in an outbreak of adenovirus type 8 kerato-conjunctivitis in 1976-7 followed by adenovirus type 19 kerato-conjunctivitis in 1978-9. During these two periods of peak incidence, 53 cases of adenovirus type 8 and 43 cases of adenovirus type 19 kerato-conjunctivitis were confirmed by isolation. Read More
Rev Med Chir Soc Med Nat Iasi 1980 Apr-Jun;84(2):257-61
Arch Ophthalmol 1979 Dec;97(12):2336-8
A new adenovirus of intermediate type involved in conjunctivitis has been isolated. The virus is related to adenovirus types 13 and 30 by neutralization and to types 10 and 19 by hemagglutination inhibition. Since 1976 the agent has been causing sporadic cases of conjunctivitis in different parts of The Netherlands. Read More
J Infect Dis 1979 Jul;140(1):42-7
During the summer of 1977, an outbreak of pharyngoconjunctival fever (PCF) occurred at a private recreational facility in Georgia. A total of 72 cases of PCF was identified. Adenovirus type 4 (AV-4) was recovered from conjunctival or pharyngeal swab specimens from 20 of 26 persons in the group of cases tested. Read More
Ophthalmologica 1978 ;177(3):134-9
A case of laboratory-acquired type 19 adenovirus infection is reported. The patient showed the classical triad of pharyngitis, acute follicular conjunctivitis and fever. Adenovirus type 19 was isolated from the affected eye, and the infection was confirmed by demonstration of seroconversion to this virus. Read More
Invest Ophthalmol Vis Sci 1977 Mar;16(3):195-200
A direct immunofluorescence technique for the diagnosis of acute adenoviral keratoconjunctivitis and pharyngoconjunctivitis was found to be a reliable, sensitive, and specific technique for the detection of soluble adenoviral antigens in epithelial cells on conjunctival scrapings of patients with epidemic keratoconjunctivitis. Of 25 patients with clinical findings consistent with epidemic keratoconjunctivitis or pharyngoconjunctival fever, all had positive diagnostic scrapings by direct immunofluorescence. Read More
Infect Immun 1975 Jun;11(6):1362-70
Although human infection with adenovirus-associated virus (AAV) has been demonstrated, there is no evidence that disease results from such infections. The proportion of adenovirus infections which are dual infections with AAV is virtually unknown, since special methods are required to demonstrate infection with AAV. To search for AAV, we re-examined a collection of specimens from 40 persons involved in an epidemic of pharyngoconjunctival fever associated with a swimming pool. Read More
Isr J Med Sci 1974 Dec;10(12):1505-9
Cesk Epidemiol Mikrobiol Imunol 1968 Oct;17(6):321-7