5,608 results match your criteria Pharyngoconjunctival Fever


Inhibition of human adenovirus replication by the importin α/β1 nuclear import inhibitor ivermectin.

J Virol 2020 Jul 8. Epub 2020 Jul 8.

Department of Microbiology & Immunology, University of Western Ontario, London, Ontario, Canada

Human adenoviruses (HAdV) are ubiquitous within the human population and comprise a significant burden of respiratory illnesses worldwide. Pediatric and immunocompromised individuals are at particular risk for developing severe disease, however, no approved antiviral therapies specific to HAdV exist. Ivermectin is an FDA-approved broad spectrum antiparasitic drug that also exhibits antiviral properties against a diverse range of viruses. Read More

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http://dx.doi.org/10.1128/JVI.00710-20DOI Listing

Evaluation of Chimpanzee Adenovirus and MVA Expressing TRAP and CSP from to Prevent Malaria Relapse in Nonhuman Primates.

Vaccines (Basel) 2020 Jul 6;8(3). Epub 2020 Jul 6.

The Jenner Institute, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford OX3 7DQ, UK.

is the world's most widely distributed human malaria parasite, with over 2.8 billion people at risk in Asia, the Americas, and Africa. The 80-90% new malaria infections are due to relapses which suggest that a vaccine with high efficacy against relapses by prevention of hypnozoite formation could lead to a significant reduction in the prevalence of infections. Read More

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http://dx.doi.org/10.3390/vaccines8030363DOI Listing

Outcomes of patients with Severe Acute Respiratory Infections (SARI) admitted to the intensive care unit: results from the Egyptian Surveillance Study 2010-2014.

Multidiscip Respir Med 2020 Jan 9;15(1):465. Epub 2020 Jun 9.

Department of Clinical Pathology, Faculty of Medicine, Mansura University, Mansura, Egypt.

Background: Few data exist about respiratory viral infections in Egyptian patients. Hereby we describe the outcomes of hospitalized Egyptian patients with severe acute respiratory infections (SARI) admitted to the ICU.

Methods: A prospective study in which all hospitalized patients meeting the WHO case definition for SARI and admitted to the ICU, during the period 2010-2014, were enrolled. Read More

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http://dx.doi.org/10.4081/mrm.2020.465DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296279PMC
January 2020

The FDA-approved drug Nelfinavir inhibits lytic cell-free, but not cell-associated non-lytic transmission of human adenovirus.

Antimicrob Agents Chemother 2020 Jun 29. Epub 2020 Jun 29.

Department of Molecular Life Sciences, University of Zurich, Zurich, Switzerland

Adenoviruses (AdVs) are prevalent and give rise to chronic and recurrent disease. The human AdV (HAdV) species B and C, such as HAdV-C2, C5 and B14, cause respiratory disease, and constitute a health threat for immuno-compromised individuals. HAdV-Cs are well known for lysing cells, owing to the E3 CR1-β-encoded adenovirus death protein (ADP). Read More

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http://dx.doi.org/10.1128/AAC.01002-20DOI Listing

Acute Encephalopathy with Biphasic Seizures and Late Reduced Diffusion Associated with Dengue Infection in a Child.

J Trop Pediatr 2020 Jun 28. Epub 2020 Jun 28.

Department of Pediatrics, Sri Ramachandra Institute of Higher Education and Research, Porur, Chennai 600116, India.

Acute encephalopathy with biphasic seizures and late reduced diffusion (AESD) is a clinico-radiological syndrome in children secondary to viral or bacterial infections. The causes include viral (influenza, human herpes virus-6, adenovirus, rota) as well as bacterial infections. However, AESD with dengue infection has not been reported earlier. Read More

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http://dx.doi.org/10.1093/tropej/fmaa033DOI Listing

ABO-Incompatible Kidney Transplantation After Bone Marrow Transplantation: A Case Report.

Transplant Proc 2020 Jun 22. Epub 2020 Jun 22.

Department of Urology, Osaka City University Graduate School of Medicine, Osaka, Japan.

Many studies have been made on ABO-compatible kidney transplants following hematopoietic stem cell transplantation. However, there have been few reports on ABO-incompatible kidney transplantation following hematopoietic stem cell transplantation (HSCT). We report on the case of a successful ABO-incompatible kidney transplantation with high titers after bone marrow transplantation experienced no infectious episodes. Read More

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http://dx.doi.org/10.1016/j.transproceed.2020.01.173DOI Listing

Bioinformatics analysis reveals four major hexon variants of human adenovirus type-3 (HAdV-3) as the potential strains for development of vaccine and siRNA-based therapeutics against HAdV-3 respiratory infections.

Infect Genet Evol 2020 Jun 22:104439. Epub 2020 Jun 22.

Unit of Microbiology, AIMST University, Faculty of Medicine, Jalan Bedong Semeling, 08100 Bedong, Kedah, Malaysia.

Human adenovirus type 3 (HAdV-3) encompasses 15-87% of all adenoviral respiratory infections. The significant morbidity and mortality, especially among the neonates and immunosuppressed patients, demand the need for a vaccine or a targeted antiviral against this type. However, due to the existence of multiple hexon variants (3Hv-1 to 3Hv-25), the selection of vaccine strains of HAdV-3 is challenging. Read More

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http://dx.doi.org/10.1016/j.meegid.2020.104439DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308778PMC

Assessing the burden of viral co-infections in acute gastroenteritis in children: An eleven-year-long investigation.

J Clin Virol 2020 Jun 16;129:104513. Epub 2020 Jun 16.

Dipartimento di Promozione della Salute, Materno-Infantile, di Medicina Interna e Specialistica di Eccellenza "G. D'Alessandro", Università di Palermo, Palermo, Italy.

Background: Acute gastroenteritis is an important cause of childhood morbidity and mortality worldwide. A number of pathogens are responsible for human acute gastroenteritis. The recent introduction of syndromic assays for the diagnosis of enteric infections, including a wide panel of enteric pathogens, has unveiled the frequency of mixed infections. Read More

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http://dx.doi.org/10.1016/j.jcv.2020.104513DOI Listing

Adenovirus Infections in African Humans and Wild Non-Human Primates: Great Diversity and Cross-Species Transmission.

Viruses 2020 Jun 18;12(6). Epub 2020 Jun 18.

IHU Méditerranée Infection, 13385 Marseille CEDEX 05, France.

Non-human primates (NHPs) are known hosts for adenoviruses (AdVs), so there is the possibility of the zoonotic or cross-species transmission of AdVs. As with humans, AdV infections in animals can cause diseases that range from asymptomatic to fatal. The aim of this study was to investigate the occurrence and diversity of AdVs in: (i) fecal samples of apes and monkeys from different African countries (Republic of Congo, Senegal, Djibouti and Algeria), (ii) stool of humans living near gorillas in the Republic of Congo, in order to explore the potential zoonotic risks. Read More

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http://dx.doi.org/10.3390/v12060657DOI Listing

Brincidofovir for the treatment of human adenovirus infection in pediatric solid organ transplant recipients: A case series.

Pediatr Transplant 2020 Jun 18:e13769. Epub 2020 Jun 18.

Division of Infectious Diseases, Department of Pediatrics, Emory University and Children's Healthcare of Atlanta, Atlanta, Georgia.

HAdV viremia can cause significant morbidity among pediatric recipients of SOT with variability in incidence and severity of disease based on the type of allograft. Currently, there are no US FDA-approved treatments for HAdV infections, and historically, the mainstay of treatment has been decreasing immunosuppression, with antiviral therapies reserved for those with severe disease. We describe the treatment of four pediatric SOT recipients (two kidney, one combined kidney-liver, and one liver) presenting with HAdV disease at our institution using brincidofovir. Read More

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http://dx.doi.org/10.1111/petr.13769DOI Listing

MHC class II invariant chain-adjuvanted viral vectored vaccines enhances T cell responses in humans.

Sci Transl Med 2020 Jun;12(548)

Nuffield Department of Medicine, University of Oxford, Oxford OX3 7BN, UK.

Strategies to enhance the induction of high magnitude T cell responses through vaccination are urgently needed. Major histocompatibility complex (MHC) class II-associated invariant chain (Ii) plays a critical role in antigen presentation, forming MHC class II peptide complexes for the generation of CD4 T cell responses. Preclinical studies evaluating the fusion of Ii to antigens encoded in vector delivery systems have shown that this strategy may enhance T cell immune responses to the encoded antigen. Read More

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http://dx.doi.org/10.1126/scitranslmed.aaz7715DOI Listing

Human adenovirus Coinfection aggravates the severity of Mycoplasma pneumoniae pneumonia in children.

BMC Infect Dis 2020 Jun 16;20(1):420. Epub 2020 Jun 16.

National Clinical Research Center for Respiratory Diseases, Key Laboratory of Major Diseases in Children, Ministry of Education, Beijing Key Laboratory of Pediatric Respiratory Infection diseases, Research Unit of Critical Infection in Children, Chinese Academy of Medical Sciences, 2019RU016, Laboratory of Infection and Virology, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.

Background: Mycoplasma pneumoniae (M. pneumoniae) is an important pathogen of community-acquired pneumonia (CAP) in children. The coinfection rate of M. Read More

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http://dx.doi.org/10.1186/s12879-020-05152-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296888PMC

In vitro co-infection by cytomegalovirus improves the antiviral activity of ganciclovir against human adenovirus.

Int J Antimicrob Agents 2020 Jun 12:106046. Epub 2020 Jun 12.

Unit of Infectious Diseases, Microbiology and Preventive Medicine, Institute of Biomedicine of Seville (IBiS), University Hospital Virgen del Rocío/CSIC/University of Seville, E41013 Seville, Spain. Electronic address:

Adenovirus (HAdV) infection may have an important clinical impact in the immunosuppressed population with high morbidity and mortality rates. The lack of a specific, safe and effective antiviral treatment against HAdV makes necessary the search for new therapeutic alternatives. The aim of this study was to evaluate the in vitro activity of ganciclovir (GCV) against HAdV in co-infection by cytomegalovirus (HCMV) and HAdV in cellular cultures. Read More

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http://dx.doi.org/10.1016/j.ijantimicag.2020.106046DOI Listing

[Practice and thinking of acute respiratory infection surveillance for the response of emerging respiratory diseases in Shanghai].

Zhonghua Liu Xing Bing Xue Za Zhi 2020 Jun 16;41(0):E073. Epub 2020 Jun 16.

Shanghai Institute of Prevention Medicine, Shanghai 200336, China; School of Public Health,Fudan University,Shanghai 200032. China.

Shanghai Municipal Center for Disease Control and Prevention has implemented an active comprehensive surveillance project of acute respiratory infections in adults in Shanghai, including influenza like illness (ILI) and severe acute respiratory infection (SARI). By testing and identifying a variety of respiratory pathogens, it was found that influenza viruses were the main pathogens in 172 ILI cases in 2019. The positive rates of influenza A (H1N1) pdm09 virus, influenza A (H3N2) virus and influenza B virus Victoria lineage were 30. Read More

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http://dx.doi.org/10.3760/cma.j.cn112338-20200421-00616DOI Listing

Safety and efficacy assessment of allogeneic human dental pulp stem cells to treat patients with severe COVID-19: structured summary of a study protocol for a randomized controlled trial (Phase I / II).

Trials 2020 Jun 12;21(1):520. Epub 2020 Jun 12.

Tianyou Hospital, Wuhan University of Science and Technology, Wuhan, 430064, Hubei, China.

Objectives: To assess the safety and therapeutic effects of allogeneic human dental pulp stem cells (DPSCs) in treating severe pneumonia caused by COVID-19.

Trial Design: This is a single centre, two arm ratio 1:1, triple blinded, randomized, placebo-controlled, parallel group, clinical trial.

Participants: Twenty serious COVID-19 cases will be enrolled in the trial from April 6th to December 31st 2020. Read More

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http://dx.doi.org/10.1186/s13063-020-04380-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290137PMC
June 2020
2.117 Impact Factor

Evaluation of Innate Immune Mediators Related to Respiratory Viruses in the Lung of Stable COPD Patients.

J Clin Med 2020 Jun 10;9(6). Epub 2020 Jun 10.

Divisione di Pneumologia e Laboratorio di Citoimmunopatologia dell'Apparato Cardio Respiratorio, Istituti Clinici Scientifici Maugeri SpA, Società Benefit, IRCCS, Veruno, Via Revislate 13, 28010 Novara, Italy.

Little is known about the innate immune response to viral infections in stable Chronic Obstructive Pulmonary Disease (COPD). Objectives: To evaluate the innate immune mediators related to respiratory viruses in the bronchial biopsies and lung parenchyma of stable COPD patients. We evaluated the immunohistochemical (IHC) expression of Toll-like receptors 3-7-8-9 (TLR-3-7-8-9), TIR domain-containing adaptor inducing IFNβ (TRIF), Interferon regulatory factor 3 (IRF3), Phospho interferon regulatory factor 3  ( pIRF3), Interferon regulatory factor 7 (IRF7), Phospho interferon regulatory factor 7 (pIRF7), retinoic acid-inducible gene I (RIG1), melanoma differentiation-associated protein 5 (MDA5), Probable ATP-dependent RNA helicase DHX58 ( LGP2), Mitochondrial antiviral-signaling protein (MAVS), Stimulator of interferon genes (STING), DNA-dependent activator of IFN regulatory factors (DAI), forkhead box protein A3(FOXA3), Interferon alfa (IFNα), and Interferon beta (IFNβ) in the bronchial mucosa of patients with mild/moderate ( = 16), severe/very severe ( = 18) stable COPD, control smokers (CS) ( = 12), and control non-smokers (CNS) ( = 12). Read More

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http://dx.doi.org/10.3390/jcm9061807DOI Listing

Adenovirus load correlates with respiratory disease severity among hospitalized pediatric patients.

Int J Infect Dis 2020 Jun 9;97:145-150. Epub 2020 Jun 9.

Department of Epidemiology and Preventive Medicine, School of Public Health, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel; Central Virology Laboratory, Ministry of Health, Chaim Sheba Medical Center, Tel-Hashomer, Ramat-Gan, Israel. Electronic address:

Objectives: Human adenoviruses (HAdVs) are common pathogens that can cause respiratory, gastrointestinal and other infections. We investigated the correlation between adenovirus viral load in clinical respiratory samples and the respiratory disease severity in pediatric patients.

Methods: Medical records of patients hospitalized in the Sheba Medical Center (SMC) with confirmed adenovirus infection were retrospectively analyzed. Read More

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http://dx.doi.org/10.1016/j.ijid.2020.06.010DOI Listing

Phase 1 Lymfactin Study: Short-term Safety of Combined Adenoviral VEGF-C and Lymph Node Transfer Treatment for Upper Extremity Lymphedema.

J Plast Reconstr Aesthet Surg 2020 May 18. Epub 2020 May 18.

Department of Plastic Surgery, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland. Electronic address:

Objective: To study the safety and tolerability of Lymfactin treatment combined with microvascular lymph node transfer surgery in patients with upper limb lymphedema.

Background: Upper limb lymphedema is a common clinical challenge after breast cancer surgery and/or radiotherapy. Lymfactin is an adenovirus type 5-based gene therapy involving expression of human vascular endothelial growth factor C (VEGF-C) in the damaged tissue. Read More

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http://dx.doi.org/10.1016/j.bjps.2020.05.009DOI Listing

Differential Effects of Human Adenovirus E1A Protein Isoforms on Aerobic Glycolysis in A549 Human Lung Epithelial Cells.

Viruses 2020 Jun 3;12(6). Epub 2020 Jun 3.

Department of Microbiology and Immunology, The University of Western Ontario, London, ON N6A 3K7, Canada.

Viruses alter a multitude of host-cell processes to create a more optimal environment for viral replication. This includes altering metabolism to provide adequate substrates and energy required for replication. Typically, viral infections induce a metabolic phenotype resembling the Warburg effect, with an upregulation of glycolysis and a concurrent decrease in cellular respiration. Read More

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http://dx.doi.org/10.3390/v12060610DOI Listing

Chest CT features of coronavirus disease 2019 (COVID-19) pneumonia: key points for radiologists.

Radiol Med 2020 Jul 4;125(7):636-646. Epub 2020 Jun 4.

Dipartimento di Scienze Radiologiche S. O. D. Radiologia Pediatrica e Specialistica, Azienda Ospedaliera Universitaria, Ospedali Riuniti "Umberto I-G.M. Lancisi-G. Salesi", Via Conca 71, 60030, Ancona, AN, Italy.

COVID-19 is an emerging infection caused by a novel coronavirus that is moving so rapidly that on 30 January 2020 the World Health Organization declared the outbreak a Public Health Emergency of International Concern and on 11 March 2020 as a pandemic. An early diagnosis of COVID-19 is crucial for disease treatment and control of the disease spread. Real-time reverse-transcription polymerase chain reaction (RT-PCR) demonstrated a low sensibility; therefore chest computed tomography (CT) plays a pivotal role not only in the early detection and diagnosis, especially for false negative RT-PCR tests, but also in monitoring the clinical course and in evaluating the disease severity. Read More

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http://dx.doi.org/10.1007/s11547-020-01237-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7270744PMC

The Adenovirus Death Protein - a small membrane protein controls cell lysis and disease.

FEBS Lett 2020 Jun 19;594(12):1861-1878. Epub 2020 Jun 19.

Department of Molecular Life Sciences, University of Zurich, Zurich, Switzerland.

Human adenoviruses (HAdVs) cause widespread acute and persistent infections. Infections are usually mild and controlled by humoral and cell-based immunity. Reactivation of persistently infected immune cells can lead to a life-threatening disease in immunocompromised individuals, especially children and transplant recipients. Read More

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http://dx.doi.org/10.1002/1873-3468.13848DOI Listing

Clinical and epidemiological study of acute lower respiratory tract infections caused by adenovirus in hospitalized children. Nineteen years of active epidemiological surveillance.

Arch Argent Pediatr 2020 06;118(3):193-201

División Promoción y Protección de la Salud, Hospital de Niños "Ricardo Gutiérrez", Ciudad Autónoma de Buenos Aires.

Introduction: Acute lower respiratory tract infection (ALRTI) caused by adenovirus is a major cause of morbidity and mortality in children.

Objectives: To describe the clinical and epidemiological pattern and associated factors in hospitalized children.

Methods: Cross-sectional study in children admitted due to ALRTI to Hospital de Niños "Ricardo Gutiérrez," in the Autonomous City of Buenos Aires, between 2000 and 2018. Read More

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http://dx.doi.org/10.5546/aap.2020.eng.193DOI Listing

Safety, tolerability, and immunogenicity of a recombinant adenovirus type-5 vectored COVID-19 vaccine: a dose-escalation, open-label, non-randomised, first-in-human trial.

Lancet 2020 06 22;395(10240):1845-1854. Epub 2020 May 22.

Beijing Institute of Biotechnology, Beijing, China. Electronic address:

Background: A vaccine to protect against COVID-19 is urgently needed. We aimed to assess the safety, tolerability, and immunogenicity of a recombinant adenovirus type-5 (Ad5) vectored COVID-19 vaccine expressing the spike glycoprotein of a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) strain.

Methods: We did a dose-escalation, single-centre, open-label, non-randomised, phase 1 trial of an Ad5 vectored COVID-19 vaccine in Wuhan, China. Read More

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http://dx.doi.org/10.1016/S0140-6736(20)31208-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7255193PMC
June 2020
45.217 Impact Factor

[Analysis of adenovirus infection in acute respiratory tract infection cases in Shanghai from 2015 to 2019].

Zhonghua Liu Xing Bing Xue Za Zhi 2020 May;41(5):733-737

Shanghai Municipal Center for Disease Control and Prevention, Shanghai 200336, China.

To study the epidemiological characteristics and mixed infection of adenovirus in acute respiratory tract infections in Shanghai from 2015 to 2019, and to provide scientific basis for the prevention and control of adenovirus. Acute respiratory tract infections were collected from 3 hospitals in Shanghai from 2015 to 2019. Relevant information was registered and respiratory specimens were sampled for detection of respiratory pathogens by multiplex PCR. Read More

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http://dx.doi.org/10.3760/cma.j.cn112338-20190821-00611DOI Listing

Ambulance dispatch calls attributable to influenza A and other common respiratory viruses in the Netherlands (2014-2016).

Influenza Other Respir Viruses 2020 Jul 14;14(4):420-428. Epub 2020 May 14.

Centre for Infectious Disease Control Netherlands (CIb), National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands.

Background: Ambulance dispatches could be useful for syndromic surveillance of severe respiratory infections. We evaluated whether ambulance dispatch calls of highest urgency reflect the circulation of influenza A virus, influenza B virus, respiratory syncytial virus (RSV), rhinovirus, adenovirus, coronavirus, parainfluenzavirus and human metapneumovirus (hMPV).

Methods: We analysed calls from four ambulance call centres serving 25% of the population in the Netherlands (2014-2016). Read More

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http://dx.doi.org/10.1111/irv.12731DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7298355PMC

Epidemiology of Adenovirus Infections and Outcomes of Cidofovir Treatment in Severely Ill Children.

Pediatr Infect Dis J 2020 May 12. Epub 2020 May 12.

Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore.

Background: An increase in human adenovirus (HAdV) infections among hospitalized children in Singapore was observed since 2013. Young age (<2 years) and significant comorbidities have been associated with severe HAdV infections which can result in significant morbidity and mortality. Cidofovir (CDV) has been used to treat severe HAdV infections despite limited data and efficacy. Read More

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http://dx.doi.org/10.1097/INF.0000000000002726DOI Listing
May 2020
2.723 Impact Factor

Virus detections among patients with severe acute respiratory illness, Northern Vietnam.

PLoS One 2020 12;15(5):e0233117. Epub 2020 May 12.

Emerging Infectious Diseases Programme, Duke-National University of Singapore, Singapore.

Severe acute respiratory illness (SARI) is a major cause of death and morbidity in low- and middle-income countries, however, the etiologic agents are often undetermined due to the lack of molecular diagnostics in hospitals and clinics. To examine evidence for select viral infections among patients with SARI in northern Vietnam, we studied 348 nasopharyngeal samples from military and civilian patients admitted to 4 hospitals in the greater Hanoi area from 2017-2019. Initial screening for human respiratory viral pathogens was performed in Hanoi, Vietnam at the National Institute of Hygiene and Epidemiology (NIHE) or the Military Institute of Preventative Medicine (MIPM), and an aliquot was shipped to Duke-NUS Medical School in Singapore for validation. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0233117PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7217455PMC

LINCS dataset-based repositioning of rosiglitazone as a potential anti-human adenovirus drug.

Antiviral Res 2020 07 27;179:104789. Epub 2020 Apr 27.

Beijing Institute of Radiation Medicine, Beijing, 100850, PR China; Experimental Center, Shandong University of Traditional Chinese Medicine, Jinan, 250355, PR China. Electronic address:

Human adenoviruses (HAdVs) often cause mild respiratory infections. These infections, however, can potentially become fatal in immunosuppressive patients. Unfortunately, there has been no specific anti-HAdV drug approved for treatment of HAdV infections. Read More

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http://dx.doi.org/10.1016/j.antiviral.2020.104789DOI Listing
July 2020
3.938 Impact Factor

Genetic variability of human adenovirus type 7 circulating in mainland China.

PLoS One 2020 30;15(4):e0232092. Epub 2020 Apr 30.

Medical School, Anhui University of Science and Technology, Huainan city, Anhui province, People's Republic of China.

Human adenovirus (HAdV-7) is a highly contagious pathogen that causes severe respiratory illnesses. However, the epidemic patterns and genetic variability of HAdV-7 circulating in mainland China have not been well elucidated. In this study, we used Chinese HAdV sentinel surveillance data obtained from 2012-2015 to investigate the clinical features of 122 HAdV-7-positive cases and performed amplification and sequence determination of three capsid genes (penton base, hexon, and fiber) from 69 isolated viruses covering from seven provinces of China. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0232092PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7192419PMC
April 2020
3.234 Impact Factor

Evaluation of the anti-adenoviral activity of ozonated alcohol disinfectant - ALTANT.

Jpn J Infect Dis 2020 Apr 30. Epub 2020 Apr 30.

Laboratory Diagnosis Division, Infectious Disease Surveillance Center, National Institute of Infectious Diseases.

Seven species (A-G) of human mastadenovirus (HAdV) are known, and more than 100 types have been reported. HAdV is highly resistant to common hand sanitizers. Epidemic keratoconjunctivitis and pharyngoconjunctival fever caused by HAdV can be explosively transmitted in a confined space, resulting in outbreaks such as nosocomial infections. Read More

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http://dx.doi.org/10.7883/yoken.JJID.2020.058DOI Listing

Recombinant Live Attenuated Influenza Vaccine Viruses Carrying Conserved T-cell Epitopes of Human Adenoviruses Induce Functional Cytotoxic T-Cell Responses and Protect Mice against Both Infections.

Vaccines (Basel) 2020 Apr 24;8(2). Epub 2020 Apr 24.

Institute of Experimental Medicine, Saint Petersburg 197376, Russia.

Human adenoviruses (AdVs) are one of the most common causes of acute respiratory viral infections worldwide. Multiple AdV serotypes with low cross-reactivity circulate in the human population, making the development of an effective vaccine very challenging. In the current study, we designed a cross-reactive AdV vaccine based on the T-cell epitopes conserved among various AdV serotypes, which were inserted into the genome of a licensed cold-adapted live attenuated influenza vaccine (LAIV) backbone. Read More

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http://dx.doi.org/10.3390/vaccines8020196DOI Listing

A Comprehensive Review on Human Aichi Virus.

Virol Sin 2020 Apr 27. Epub 2020 Apr 27.

Departamento de Microbiología y Parasitología, CIBUS-Facultad de Biología, Universidade de Santiago de Compostela, 15782, Santiago, Spain.

Although norovirus, rotavirus, adenovirus and Astrovirus are considered the most important viral agents transmitted by food and water, in recent years other viruses, such as Aichi virus (AiV), have emerged as responsible for gastroenteritis outbreaks associated with different foods. AiV belongs to the genus Kobuvirus of the family Picornaviridae. It is a virus with icosahedral morphology that presents a single stranded RNA genome with positive sense (8280 nucleotides) and a poly (A) chain. Read More

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http://dx.doi.org/10.1007/s12250-020-00222-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7223127PMC

The UPR sensor IRE1α and the adenovirus E3-19K glycoprotein sustain persistent and lytic infections.

Nat Commun 2020 Apr 24;11(1):1997. Epub 2020 Apr 24.

Department of Molecular Life Sciences, University of Zurich, Zurich, Switzerland.

Persistent viruses cause chronic disease, and threaten the lives of immunosuppressed individuals. Here, we elucidate a mechanism supporting the persistence of human adenovirus (AdV), a virus that can kill immunosuppressed patients. Cell biological analyses, genetics and chemical interference demonstrate that one of five AdV membrane proteins, the E3-19K glycoprotein specifically triggers the unfolded protein response (UPR) sensor IRE1α in the endoplasmic reticulum (ER), but not other UPR sensors, such as protein kinase R-like ER kinase (PERK) and activating transcription factor 6 (ATF6). Read More

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http://dx.doi.org/10.1038/s41467-020-15844-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7181865PMC

Safety and immunogenicity of a candidate Middle East respiratory syndrome coronavirus viral-vectored vaccine: a dose-escalation, open-label, non-randomised, uncontrolled, phase 1 trial.

Lancet Infect Dis 2020 Jul 21;20(7):816-826. Epub 2020 Apr 21.

The Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK. Electronic address:

Background: Cases of Middle East respiratory syndrome coronavirus (MERS-CoV) infection continue to rise in the Arabian Peninsula 7 years after it was first described in Saudi Arabia. MERS-CoV poses a significant risk to public health security because of an absence of currently available effective countermeasures. We aimed to assess the safety and immunogenicity of the candidate simian adenovirus-vectored vaccine expressing the full-length spike surface glycoprotein, ChAdOx1 MERS, in humans. Read More

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http://dx.doi.org/10.1016/S1473-3099(20)30160-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7172901PMC
July 2020
22.433 Impact Factor

First Identification of Human Adenovirus Subtype 21a in China With MinION and Illumina Sequencers.

Front Genet 2020 7;11:285. Epub 2020 Apr 7.

Department of Disease Control and Prevention, Center for Disease Control and Prevention of Eastern Theater Command, Nanjing, China.

Human adenoviruses (HAdVs) have been demonstrated to cause a diversity of diseases among children and adults. The circulation of human adenovirus type 21 (HAdV21) has been mainly documented within closed environments in several countries. Nonetheless, respiratory infections or outbreaks due to HAdV21 have never been reported in China. Read More

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http://dx.doi.org/10.3389/fgene.2020.00285DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7155751PMC

Epidemiology of Human Adenoviruses: A 20-Year Retrospective Observational Study in Hospitalized Patients in Bern, Switzerland.

Clin Epidemiol 2020 5;12:353-366. Epub 2020 Apr 5.

Institute for Infectious Diseases, University of Bern, Bern, Switzerland.

Background: Human adenovirus (HAdV) is an important pathogen seen in clinical practice. Long-term studies may help better understand epidemiological trends and changes in circulating genotypes over time.

Purpose: Using a large biobank of samples from hospitalized, adenovirus-positive patients over a 20-year period, we aimed to analyze long-term epidemiological trends and genotypic relatedness among circulating HAdV strains. Read More

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http://dx.doi.org/10.2147/CLEP.S246352DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7147615PMC

Human adenovirus 36 improves insulin sensitivity and lipid profiles and increases inflammatory markers in Wistar rats.

J Investig Med 2020 Jun 16;68(5):980-984. Epub 2020 Apr 16.

Nutrition and Metabolic Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

Human adenovirus 36 (Ad-36) causes obesity with increased adiposity, in contrast, Ad-36 infection reduces glucose and lipid metabolism; the results, however, are not consistent. In the current study, the effects of Ad-36 infection on glucose and lipid profile and inflammatory markers in Wistar rats were investigated. Sixty male Wistar rats were randomly divided into infected and control groups. Read More

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http://dx.doi.org/10.1136/jim-2019-001165DOI Listing
June 2020
1.503 Impact Factor

Molecular epidemiology of influenza, RSV, and other respiratory infections among children in Qatar: A six years report (2012-2017).

Int J Infect Dis 2020 Jun 9;95:133-141. Epub 2020 Apr 9.

Biomedical Research Center, Qatar University, Doha, Qatar; College of Health Sciences-QU health, Qatar University, Doha, Qatar. Electronic address:

Background: Studies on the etiology of respiratory infections among children in Qatar and surrounding countries are limited.

Objectives: To describe the prevalence and seasonality of RSV, influenza, and other respiratory pathogens among children in Qatar.

Methods: We retrospectively collected and analyzed data of 33,404 children (<15 years) presented with influenza-like illness from 2012 to 2017. Read More

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http://dx.doi.org/10.1016/j.ijid.2020.04.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7194828PMC
June 2020
2.330 Impact Factor

Histone Deacetylase Inhibitors Promote Latent Adenovirus Reactivation from Tonsillectomy Specimens.

J Virol 2020 Jun 1;94(12). Epub 2020 Jun 1.

State Key Laboratory of Pharmaceutical Biotechnology, Medical School of Nanjing University, Nanjing, Jiangsu, China

Adenovirus (HAdV) infection is a common cause of illness among young children, immunocompromised patients, and transplant recipients. The majority of HAdV infections are self-limited, but recurring infection is frequently encountered in young children and may require hospitalization. In this study, we surveyed the presence of HAdV in tonsillectomy samples and investigated epigenetic conditions that contributed to HAdV reactivation. Read More

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http://dx.doi.org/10.1128/JVI.00100-20DOI Listing

Management of Adenoviral Keratoconjunctivitis: Challenges and Solutions.

Clin Ophthalmol 2020 17;14:837-852. Epub 2020 Mar 17.

Pennsylvania College of Optometry, Salus University, Elkins Park, PA 19027, USA.

Human adenovirus (HAdV) is the most common cause of infectious conjunctivitis, accounting for up to 75% of all conjunctivitis cases and affecting people of all ages and demographics. In addition to ocular complications, it can cause systemic infections in the form of gastroenteritis, respiratory disease, and dissemination in immunocompromised individuals. HAdV causes lytic infection of the mucoepithelial cells of the conjunctiva and cornea, as well as latent infection of lymphoid and adenoid cells. Read More

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http://dx.doi.org/10.2147/OPTH.S207976DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7094151PMC

Viral Etiology of Acute Lower Respiratory Tract Infections in Hospitalized Children in Nagasaki, a Regional City of Japan in 2013-2015.

Pediatr Infect Dis J 2020 Mar 25. Epub 2020 Mar 25.

Department of Pediatric Infectious Diseases, Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan.

Background: Acute lower respiratory tract infections (ALRIs) are the most common disease for hospitalized children in Japan. The aim of this study was to identify viruses in children hospitalized for ALRIs and to demonstrate epidemiologic and clinical characteristics in Japan.

Methods: During a 2-year period from February 2013 to January 2015, we collected nasopharyngeal swab specimens from almost all hospitalized children with ALRIs in Nagasaki, a regional city of Japan, and its environs. Read More

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http://dx.doi.org/10.1097/INF.0000000000002668DOI Listing

Predominance of Human Bocavirus Genotype 1 and 3 in Outpatient Children with Diarrhea from Rural Communities in South Africa, 2017-2018.

Pathogens 2020 Mar 25;9(4). Epub 2020 Mar 25.

Department of Microbiology, School of Mathematical and Natural Science, University of Venda, Thohoyandou 0950, South Africa.

Human bocavirus (HBoV) is an emerging virus globally associated with diarrhea in young children. This study aims to investigate the prevalence of HBoV genotypes in children (≤5 years) from rural communities in South Africa (SA) suffering from acute gastroenteritis (AGE). A total of 141 fecal samples of children ≤5 years with acute gastroenteritis (AGE) were collected from rural primary health care facilities in the Vhembe district of SA between June 2017 and July 2018. Read More

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http://dx.doi.org/10.3390/pathogens9040245DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238119PMC

Antiviral Effects of Novel 2-Benzoxyl-Phenylpyridine Derivatives.

Molecules 2020 Mar 19;25(6). Epub 2020 Mar 19.

School of Materials and Chemical Engineering, Hubei University of Technology, Wuhan 430068, China.

Coxsackievirus B3 (CVB3) is the most common cause of acute and chronic viral myocarditis, primarily in children, while human adenovirus infections represent a significant cause of morbidity and mortality worldwide, in people of all ages. A series of novel 2-benzoxyl-phenylpyridine derivatives were evaluated for their potential antiviral activities against CVB3 and adenovirus type 7 (ADV7). Preliminary assays indicated that some of these compounds exhibited excellent antiviral effects on both CVB3 and ADV7 viruses; they could effectively inhibit virus-induced cytopathic effects, reduce viral progeny yields, and had similar or superior antiviral activities compared with the control drug, ribavirin. Read More

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http://dx.doi.org/10.3390/molecules25061409DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7144376PMC
March 2020
2.416 Impact Factor

Comparison of the Panther Fusion respiratory panels to routine methods for detection of viruses in upper and lower respiratory tract specimens.

Diagn Microbiol Infect Dis 2020 Jun 7;97(2):115014. Epub 2020 Feb 7.

Division of Clinical Microbiology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905. Electronic address:

Viral respiratory infections remain a significant cause of morbidity and mortality in pediatric, elderly, and immunocompromised patients. The Panther Fusion respiratory panels consist of 3 separate multiplex assays that test for 1) influenza A, influenza B, and RSV; 2) parainfluenza virus types 1-4; or 3) adenovirus, human metapneumovirus, and rhinovirus. This study evaluated the performance of the Fusion assays for both upper and lower respiratory tract specimens in comparison to routine methods, including viral culture and targeted real-time polymerase chain reaction assays. Read More

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http://dx.doi.org/10.1016/j.diagmicrobio.2020.115014DOI Listing

Molecular and Epidemiologic Analysis of Diarrheal Pathogens in Children With Acute Gastroenteritis in Bangladesh During 2014-2019.

Pediatr Infect Dis J 2020 Jul;39(7):580-585

From the Department of Microbiology, Jahangirnagar University, Savar, Dhaka, Bangladesh.

Background: Diarrheal disease is one of the leading causes of childhood morbidity and mortality in the 21st century in developing countries. Mainly infants and young children develop diarrheal diseases. This study aims to determine the incidence of diarrheal pathogens in children in Bangladesh. Read More

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http://dx.doi.org/10.1097/INF.0000000000002637DOI Listing
July 2020
2.723 Impact Factor

Ginkgolic acid inhibits fusion of enveloped viruses.

Sci Rep 2020 03 16;10(1):4746. Epub 2020 Mar 16.

Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.

Ginkgolic acids (GA) are alkylphenol constituents of the leaves and fruits of Ginkgo biloba. GA has shown pleiotropic effects in vitro, including: antitumor effects through inhibition of lipogenesis; decreased expression of invasion associated proteins through AMPK activation; and potential rescue of amyloid-β (Aβ) induced synaptic impairment. GA was also reported to have activity against Escherichia coli and Staphylococcus aureus. Read More

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http://dx.doi.org/10.1038/s41598-020-61700-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7075884PMC

Regulation of Protein Kinase R by Epstein-Barr Virus EBER1 RNA.

Biochemistry 2020 03 18;59(12):1252-1260. Epub 2020 Mar 18.

Protein kinase R (PKR) is a key antiviral component of the innate immune pathway and is activated by viral double-stranded RNAs (dsRNAs). Adenovirus-associated RNA 1 (VAI) is an abundant, noncoding viral RNA that functions as a decoy by binding PKR but not inducing activation, thereby inhibiting the antiviral response. In VAI, coaxial stacking produces an extended helix that mediates high-affinity PKR binding but is too short to result in activation. Read More

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http://dx.doi.org/10.1021/acs.biochem.0c00088DOI Listing

Human coronavirus OC43 and other respiratory viruses from acute respiratory infections of Egyptian children.

Acta Microbiol Immunol Hung 2020 Mar 9:1-8. Epub 2020 Mar 9.

Department of Microbiology, Medical Research Institute, University of Alexandria, Alexandria, Egypt.

Respiratory infections have a significant impact on health worldwide. Viruses are major causes of acute respiratory infections among children. Limited information regarding its prevalence in Egypt is available. Read More

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http://dx.doi.org/10.1556/030.2020.01059DOI Listing

Epidemiology and Outcomes of Early-Onset and Late-Onset Adenovirus Infections in Kidney Transplant Recipients.

Open Forum Infect Dis 2019 Dec 13;6(12):ofz489. Epub 2019 Nov 13.

Division of Infectious Diseases, Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

Objective: Adenovirus (ADV) infection after kidney transplantation (KT) causes significant morbidity. Patient characteristics and outcomes of ADV infection in KT recipients were investigated.

Method: All adult KT recipients with ADV infection between January 2015 and June 2019 were included. Read More

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http://dx.doi.org/10.1093/ofid/ofz489DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7047955PMC
December 2019