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BMJ Open 2020 Jun 1;10(6):e036703. Epub 2020 Jun 1.

Department of Global Public Health, Karolinska Institutet, Stockholm, Sweden.

Objectives: To assess variation in antibiotic prescribing practices among village doctors in a rural region of Shandong province, China.

Design, Setting And Participants: Almost all outpatient encounters at village clinics result in a prescription being issued. Prescriptions were collected over a 2. Read More

J Antimicrob Chemother 2020 May 25. Epub 2020 May 25.

Université de Paris, Epidemiology and Statistics Research Center - CRESS, INSERM, Obstetrical, Perinatal and Pediatric Epidemiology research team, F-75004 Paris, France.

Objectives: To assess recent community antibiotic prescribing for French children and identify areas of potential improvement.

Methods: We analysed 221 768 paediatric (<15 years) visits in a national sample of 680 French GPs and 70 community paediatricians (IQVIA's EPPM database), from March 2015 to February 2017, excluding well-child visits. We calculated antibiotic prescription rates per 100 visits, separately for GPs and paediatricians. Read More

Virulence 2020 12;11(1):482-485

Infectious Diseases Department, The First Hospital of Jilin University, Changchun, China.

Since its outbreak in Wuhan, Hubei Province China, 2019-coronavirus infected disease (COVID-19) had been widely spread all over the world, the control of which calls for a better understanding of its epidemiology and clinical characteristics. We included 12 confirmed cases of COVID-19 in First Affiliated Hospital of Jilin University from 23 January 2020 to 11 February 2020, which were retrospectively analyzed for epidemiological, demographic, clinical, laboratory, and radiological features. All the patients were confirmed by nucleic acid detection, the average age of whom was 45. Read More

IDCases 2020 5;20:e00785. Epub 2020 May 5.

University of Maryland Medical Center, Department of Medicine, Division of Infectious Disease. 22 South Greene St, Baltimore MD 21201, United States.

gynecological infections generally occur in association with childbirth, intra-uterine devices, and other invasive gynecologic procedures, but rarely cause spontaneous pelvic inflammatory disease. We describe a case of a healthy young woman with spontaneous pelvic inflammatory disease, bacteremia, and shock, and summarize an additional 13 cases found in the literature. The majority were bacteremic and a significant number were also hypotensive. Read More

Pediatr Infect Dis J 2020 06;39(6):469-477

Department of Paediatrics, The University of Melbourne, Parkville, Australia.

The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has spread rapidly across the globe. In contrast to initial reports, recent studies suggest that children are just as likely as adults to become infected with the virus but have fewer symptoms and less severe disease. In this review, we summarize the epidemiologic and clinical features of children infected with SARS-CoV-2 reported in pediatric case series to date. Read More

Euro Surveill 2020 04;25(16)

Department of Medical Microbiology, Radboud Centre for Infectious Diseases, Radboud university medical centre, Nijmegen, The Netherlands.

Healthcare workers (n = 803) with mild symptoms were tested for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (n = 90 positive) and asked to complete a symptom questionnaire. Anosmia, muscle ache, ocular pain, general malaise, headache, extreme tiredness and fever were associated with positivity. A predictive model based on these symptoms showed moderate discriminative value (sensitivity: 91. Read More

Clin Infect Dis 2020 Apr 23. Epub 2020 Apr 23.

Centers for Disease Control and Prevention, Atlanta, Georgia, USA.

Background: Improving appropriate antibiotic use is crucial for combating antibiotic resistance and unnecessary adverse drug reactions. Acute respiratory illness (ARI) commonly causes outpatient visits and accounts for ~41% of antibiotics used in the United States (U.S. Read More

Medicine (Madr) 2019 Nov 11;12(91):5339-5351. Epub 2019 Dec 11.

Servicio de Otorrinolaringología, Hospital Universitario Príncipe de Asturias, Alcalá de Henares, Madrid, España.

Infections are the most common cause of antibiotic prescription and one of the most frequent reasons for consultation in Primary Care. Among them, stand out acute media otitis and diffuse external otitis, acute pharyngitis and acute rhinosinusitis. Commonly they are viral and self-limited, so their complications are rare. Read More

Can Fam Physician 2020 Apr;66(4):251-257

Assistant Professor and Research Director in the Department of Otolaryngology at Queen's University and Adjunct Scientist with ICES Queen's.

Objective: To provide family physicians with an updated approach to diagnosis and treatment of pharyngitis, detailing key symptoms, methods of investigation, and a summary of common causes.

Sources Of Information: The approach described is based on the authors' clinical practice and peer-reviewed literature from 1989 to 2018.

Main Message: Sore throat caused by pharyngitis is commonly seen in family medicine clinics and is caused by inflammation of the pharynx and surrounding tissues. Read More

J Korean Med Sci 2020 Apr 6;35(13):e142. Epub 2020 Apr 6.

Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.

Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected pneumonia emerged in Wuhan, China in December 2019. In this retrospective multicenter study, we investigated the clinical course and outcomes of novel coronavirus disease 2019 (COVID-19) from early cases in Republic of Korea.

Methods: All of the cases confirmed by real time polymerase chain reaction were enrolled from the 1st to the 28th patient nationwide. Read More

Vestn Otorinolaringol 2020 ;85(1):22-24

Pirogov Russian National Research Medical University of the Ministry of Health of Russia, Department of Otolaryngology of Pediatric Faculty, Moscow, Russia, 117997.

Group A β-hemolytic streptococcus (GABHS) is the most important bacterial agent in the genesis of acute inflammatory conditions of the pharynx due to the possible development of local and systemic complications. During the seasonal increase of incidence of respiratory viral infections, the possibility of viral-bacterial co-infection is often not taken into account.

Aim: Determine the incidence of GABHS in children with catarrhal symptoms (rhinorrhea, cough) and without them. Read More

J Am Acad Dermatol 2020 05 19;82(5):1217-1218. Epub 2020 Mar 19.

St. George Hospital, University of New South Wales, Sydney, Australia.

Indian J Pediatr 2020 04 13;87(4):281-286. Epub 2020 Mar 13.

Department of Pediatrics and Infectious Disease, Kokilaben Dhirubhai Ambani Hospital and Medical Research Institute, Mumbai, India.

There is a new public health crises threatening the world with the emergence and spread of 2019 novel coronavirus (2019-nCoV) or the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The virus originated in bats and was transmitted to humans through yet unknown intermediary animals in Wuhan, Hubei province, China in December 2019. There have been around 96,000 reported cases of coronavirus disease 2019 (COVID-2019) and 3300 reported deaths to date (05/03/2020). Read More

PLoS One 2020 12;15(3):e0230183. Epub 2020 Mar 12.

Department of Clinical Microbiology, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark.

Acute respiratory tract infections (ARTI), including the common cold, pharyngitis, sinusitis, otitis media, bronchiolitis and pneumonia are the most common diagnoses among patients seeking medical care in western countries, and account for most antibiotic prescriptions. While a confirmed and fast ARTI diagnosis is key for antibiotic prescribing, empiric antimicrobial treatment remains common, because viral symptoms are often clinically similar and difficult to distinguish from those caused by bacteria. As a result, inappropriate antibiotic prescriptions are high and in certain settings likely higher than the commonly estimated 30%. Read More

Lancet 2020 03 12;395(10226):809-815. Epub 2020 Feb 12.

Department of Gynaecology and Obstetrics, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China; Clinical Medicine Research Centre of Prenatal Diagnosis and Birth Health in Hubei Province, Wuhan, Hubei, China. Electronic address:

Background: Previous studies on the pneumonia outbreak caused by the 2019 novel coronavirus disease (COVID-19) were based on information from the general population. Limited data are available for pregnant women with COVID-19 pneumonia. This study aimed to evaluate the clinical characteristics of COVID-19 in pregnancy and the intrauterine vertical transmission potential of COVID-19 infection. Read More

Clin Microbiol Infect 2020 Feb 29. Epub 2020 Feb 29.

Service de Bactériologie-Hygiène Hospitalière, CHU de Rennes, Rennes, France; CNR de `la Résistance aux Antibiotiques (laboratoire associé'Entérocoques), Rennes, France; Unité Inserm U1230, Université de Rennes 1, Rennes, France. Electronic address:

Background: Rapid diagnostic tests (RDTs) for infectious diseases, with a turnaround time of less than 2 hours, are promising tools that could improve patient care, antimicrobial stewardship and infection prevention in the emergency department (ED) setting. Numerous RDTs have been developed, although not necessarily for the ED environment. Their successful implementation in the ED relies on their performance and impact on patient management. Read More

J Pediatr 2020 May 14;220:132-138.e2. Epub 2020 Feb 14.

Department of Pediatrics, Boston Children's Hospital, Boston, MA; Division of Emergency Medicine, Boston Children's Hospital, Boston, MA.

Objectives: To determine the prevalence of features of viral illness in a national sample of visits involving children tested for group A Streptococcus pharyngitis. Additionally, we sought to derive a decision rule to identify patients with features of viral illness who were at low risk of having group A Streptococcus and for whom laboratory testing might be avoided.

Study Design: Retrospective validation study using data from electronic health records of patients 3-21 years old evaluated for sore throat in a national network of retail health clinics (n = 67 127). Read More

Vestn Otorinolaringol 2019 ;84(6):100-107

Russian Medical Academy of Post-Graduate Education, Moscow, Russia, 123242; Children's City Clinical Hospital Z.A. Bashlyaevoi, Moscow, Russia, 125373.

In recent years, OME in childhood tends to increase. The low efficiency of the currently used traditional methods of conservative therapy and the high rate of relapse of the disease make it necessary to develop new methods of treatment. It is important that there is a connection of development of OME and hypertrophy of the lymphoid tissue of the nasopharynx, which in childhood is considered as a response to the respiratory antigenic virus-bacterial load. Read More

Medicine (Baltimore) 2020 Jan;99(3):e18764

Department of Gastroenterology.

Rationale: Epstein-Barr virus (EBV)-associated T-cell lymphoproliferative disorder (LPD) usually occurs in children and young adults. Gastrointestinal involvement is rare. EBV-associated T-cell lymphoproliferative disorder manifesting as intestinal ulcers poses diagnostic challenges clinically and pathologically because of the atypical manifestations. Read More

J Ethnopharmacol 2020 May 29;253:112634. Epub 2020 Jan 29.

School of Life Sciences, Beijing University of Chinese Medicine, Beijing, 100102, China. Electronic address:

Ethnopharmacological Relevance: Flos Trollii is the dried flowers of Trollius chinensis. It has been used as a traditional herbal medicine for the treatment of upper respiratory tract infection, tonsillitis and pharyngitis in China for a long history. Veratric acid, vitexin, and trolline are the representative compounds of phenolic acids, flavonoids and alkaloids in this herbal medicine. Read More

J Ethnopharmacol 2020 Apr 21;252:112584. Epub 2020 Jan 21.

State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, PR China; Faculty of Chinese Medicine, Macau University of Science and Technology, Taipa, Macau SAR, PR China; KingMed Virology Diagnostic & Translational Center, Guangzhou, Guangdong, PR China. Electronic address:

Ethnopharmacological Relevance: Liu Shen Wan (LSW), first prescribed in "Lei Yunshang Song Fen Tang Fang", traditional Chinese medicine (TCM), is used to cure influenza, tonsillitis, pharyngitis and mumps for more than one hundred years.

Aim Of Study: LSW was proved extensive pharmacological properties, for instance, anti-inflammatory, anticancer, antiviral, analgesic, antibacterial and immunomodulatory activities. Nevertheless, the mechanism of this process and the evaluation of this product is still ambiguous. Read More

J Basic Clin Physiol Pharmacol 2020 Jan 11;30(6). Epub 2020 Jan 11.

Faculty of Pharmacy, Universitas Airlangga, Department of Clinical Pharmacy, Kampus C UNAIR, Mulyorejo Rd. Surabaya, Indonesia.

Background Inappropriate antibiotic therapy is accelerating the development of antimicrobial resistance (AMR). Upper respiratory tract infections (URTIs) are predominantly caused by viruses, resulting in the prescription of antibiotics to a few selected patients. Previous studies in primary health care centers (PHCCs) in Indonesia have shown a high percentage of antibiotic therapy for URTIs. Read More

J Pain Res 2019 27;12:3477-3509. Epub 2019 Dec 27.

Evidence Generation and Clinical Research, Reckitt Benckiser Healthcare Ltd, Hull, HU8 7DS, UK.

Background: Antibiotics are inappropriately prescribed to many people with sore throat. As most cases of sore throat are viral and/or self-limiting, guidelines recommend symptomatic management as first-line treatment. This paper reviews the available clinical evidence for the efficacy and safety of low-dose (8. Read More

Orv Hetil 2020 Jan;161(2):50-55

Klinikai Mikrobiológiai Diagnosztikai Intézet, Szegedi Tudományegyetem, Szent-Györgyi Albert Klinikai Központ Szeged, Semmelweis u. 6., 6725.

Exudative tonsillitis is a common clinical picture during childhood. The majority of these cases are caused by viruses (Epstein-Barr virus [EBV], cytomegalovirus [CMV], influenza virus, parainfluenza virus, and adenovirus), and only some infections are caused by bacteria, mainly group A streptococci (GAS). On the basis of international guidelines, routine use of early antibiotic treatment is not recommended in these cases, because it seems not to prevent GAS-associated complications. Read More

Am J Trop Med Hyg 2020 02;102(2):377-383

Nuffield Department of Medicine, Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, United Kingdom.

Pharyngitis is usually caused by a viral infection for which antibiotics are often unnecessarily prescribed, adding to the burden of antimicrobial resistance. Identifying who needs antibiotics is challenging; microbiological confirmation and clinical scores are used but have limitations. In a cross-sectional study nested within a randomized controlled trial, we estimated the prevalence and antibiotic susceptibility profiles of group A (GAS) in patients presenting to primary care with a sore throat and fever in northern Thailand. Read More

BMJ Case Rep 2019 Dec 22;12(12). Epub 2019 Dec 22.

Infectious Diseases Section, University General Hospital of Patras, Patras, Achaia, Greece

Am J Emerg Med 2019 Nov 18. Epub 2019 Nov 18.

Division of Emergency Medicine, Boston Children's Hospital, Boston, MA, United States; Departments of Pediatrics and Emergency Medicine, Harvard Medical School, Boston, MA, United States.

Background: Clinicians use the Modified Centor Score (MCS) to estimate the risk of group A streptococcal (GAS) pharyngitis in children with sore throat. The Infectious Diseases Society of America (IDSA) recommends neither testing nor treating patients with specific viral symptoms. The goal of this study is to measure the impact of those symptoms on the yield of GAS testing predicted by the MCS. Read More

Am Fam Physician 2019 12;100(11):713-714

Naval Hospital Jacksonville, Jacksonville, FL, USA.

Cutis 2019 Oct;104(4):248-249

57 West Dermatology, New York, New York, USA.

Guttate psoriasis is a variant of psoriasis characterized by small, 2- to 10-mm, raindroplike lesions on the skin. Guttate psoriasis is commonly triggered by group A streptococcal pharyngitis. We describe a novel case of guttate psoriasis following presumed coxsackievirus A hand-foot-and-mouth disease (HFMD). Read More

J Family Med Prim Care 2019 Oct 31;8(10):3130-3135. Epub 2019 Oct 31.

Department of Pediatrics, Pt BD Sharma PGIMS, Shimla, Himachal Pradesh, India.

Background And Aims: Antibiotics are frequently prescribed for sore throat in developing countries, that in turn leads to huge healthcare expenditure and their irrational use may lead to antimicrobial resistance in the community. The aim of this study is to investigate the effect of environmental factors on the frequency of occurrence of group A beta hemolytic streptococcus (GABHS) sore throat and to work out enhancing effect on the sensitivity and specificity and positive predictive value of the signs and symptoms of GABHS sore throat for facilitation of rational antibiotic use.

Settings And Design: This was a prospective, cross sectional study conducted over period of one year in Pediatric Outpatient Department (OPD) of a Tertiary care teaching hospital. Read More

Int J Infect Dis 2020 Feb 13;91:1-8. Epub 2019 Nov 13.

Division of General Internal Medicine, Jichi Medical University Hospital, 3311-1 Yakushiji, Shimotsuke-shi, Tochigi 329-0498, Japan; Division of Infectious Diseases, Jichi Medical University Hospital, 3311-1 Yakushiji, Shimotsuke-shi, Tochigi 329-0498, Japan. Electronic address:

Objectives: To evaluate condition-specific antibiotic prescription rates and the appropriateness of antibiotic use in outpatient settings in Japan.

Methods: Using Japan's national administrative claims database, all outpatient visits with infectious disease diagnoses were linked to reimbursed oral antibiotic prescriptions. Prescription rates stratified by age, sex, prefecture, and antibiotic category were determined for each infectious disease diagnosis. Read More

Medicine (Baltimore) 2019 Nov;98(46):e17220

Department of Clinical Pharmacology, Institute of Physiology and Pharmacology, Lithuanian University of Health Sciences.

The purpose of this study was to determine the trends in consumption of antibiotics and evaluate the antibiotic prescription rates in the pediatric population in Lithuania during 2003 to 2012.A cross-sectional study. Data of systemic antibiotic use in pediatric population for outpatient treatment was derived from National Health Insurance Fund database. Read More

FP Essent 2019 Nov;486:11-18

Hospital Medicine for Family Physicians Fellowship at Womack Army Medical Center, 2817 Reilly Road Fort Bragg, NC 28310-7301.

Upper respiratory tract infections (URTIs) include the common cold, rhinosinusitis, pharyngitis, and acute otitis media (AOM). URTIs account for billions of dollars in annual health care costs; acute respiratory tract infections are the most common reason for acute care appointments. Although URTIs typically are viral, these infections are the most common reason for prescription of antibiotics in adults. Read More

Ital J Pediatr 2019 Oct 18;45(1):129. Epub 2019 Oct 18.

Department of Health Promotion Sciences Maternal and Infantile Care, Internal Medicine and Medical Specialities "G. D'Alessandro", University of Palermo, Palermo, Italy.

Background: Familial Mediterranean Fever is a monogenic autoinflammatory disease, secondary to mutation of MEFV gene, and typically expressed with recurrent attacks of fever, serositis, rash, aphthous changes in lips and/or oral mucosa. Kawasaki Disease, an acute systemic vasculitis with persistent fever (5 or more days), rash, stomatitis, conjunctivitis, lymphadenopathy, changes in extremities, is currently considered a multifactorial autoinflammatory disease. An infection, as Epstein Barr virus, can be the trigger of Kawasaki Disease. Read More

Inflammopharmacology 2020 Feb 24;28(1):299-310. Epub 2019 Aug 24.

Institute of Tropical Medicine, Guangzhou University of Chinese Medicine, 12 Jichang Rd., San Yuanli St., Bai Yun Dist., Guangzhou, 510405, Guangdong, People's Republic of China.

Background: Influenza is an acute viral respiratory illness that causes high morbidity and mortality globally. Therapeutic actions are limited to vaccines and a few anti-viral drugs. Polygala (P. Read More

J Transl Med 2019 08 23;17(1):284. Epub 2019 Aug 23.

Università degli Studi di Milano, Milan, Italy.

Background: Over many years, OM-85, a lysate of 21 common bacterial respiratory pathogens, has been demonstrated to prevent respiratory recurrences in children. However, further studies are needed to explore the true importance of OM-85 in the prevention of respiratory tract infections (RTIs) in children. This study was planned to further contribute to the evaluation of the role played by OM-85 in prevention of recurrent RTIs in children. Read More

J Clin Pharm Ther 2019 Dec 13;44(6):829-837. Epub 2019 Aug 13.

Reckitt Benckiser Healthcare Ltd UK, Slough, UK.

What Is Known And Objective: The overuse and misuse of antibiotics, especially for viral, and self-limiting, respiratory tract infections such as sore throat, increases the risk of the development and spread of antimicrobial resistance within communities. Up to 80% of sore throat cases have a viral aetiology, and even when the infection is bacterial, most cases resolve without antibiotics. However, antibiotics are still frequently and often inappropriately prescribed for the treatment of sore throat. Read More

BMC Infect Dis 2019 Aug 1;19(1):681. Epub 2019 Aug 1.

Department of Pediatrics, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, 138, Sheng Li Road, North Dist, Tainan, 70403, Taiwan.

Background: Human adenoviruses (HAdV) are important pathogens of pediatric respiratory tract infections in Taiwan. There were two major HAdV epidemics in southern Taiwan in 2011 and 2014, respectively.

Methods: The demographic, clinical characteristics, and risk factors for hospitalization of pediatric patients with HAdV infection in the two outbreaks were retrospectively compared. Read More

BMJ 2019 Jul 25;366:l4361. Epub 2019 Jul 25.

Queen Elizabeth Hospital Birmingham, Birmingham, UK.

BMC Infect Dis 2019 Jul 17;19(1):633. Epub 2019 Jul 17.

Department of Public Health, University of Otago, Wellington, New Zealand.

Background: Group A Streptococcal (GAS) infections cause the autoimmune disease acute rheumatic fever (ARF), which can progress to chronic rheumatic heart disease (RHD). Treating pharyngitis caused by GAS with antibiotics is important in preventing ARF. However, it is difficult to distinguish these infections from GAS carriers. Read More

Eur Arch Otorhinolaryngol 2019 Oct 12;276(10):2865-2871. Epub 2019 Jul 12.

Head and Neck Surgery Unit, Department of Otolaryngology-Head and Neck Surgery, Galilee Medical Center, POB 21, 2210001, Nahariya, Israel.

Introduction: The presence of high-risk HPV in non-malignant tonsil tissues from patients who underwent tonsillectomy in the Galilee area might explain the low incidence of HPV-related oropharyngeal malignancy in the country. The aim of this retrospective study was to study the prevalence of human papillomavirus (HPV) in non-malignant tonsillectomy specimens of adults in the Galilee area.

Materials And Methods: We conducted a retrospective analysis of all tonsil samples in our medical center. Read More

Acta Otolaryngol 2019 Sep 26;139(9):798-802. Epub 2019 Jun 26.

a Department of Otorhinolaryngology - Head and Neck Surgery, Helsinki University Hospital , Helsinki , Finland.

The purpose of this prospective study was to determine if there is a difference in number and distribution of salivary bacteria between patients with tonsillar infection and healthy volunteers. The etiology of peritonsillar abscess (PTA) is unclear. Smoking, periodontal disease, and infection of minor salivary glands have been suggested as predisposing factors for PTA. Read More

J Microbiol Immunol Infect 2019 Dec 21;52(6):858-864. Epub 2019 May 21.

Department of Pediatrics, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan. Electronic address:

Background/purpose(s): Enterovirus D68(EV-D68) is an emerging disease that affects mostly children. There have been few relevant investigations to clarify transmission and seroprevalence within daycares and kindergartens.

Methods: This prospective cohort study investigated respiratory viral transmission among preschool children in a public kindergarten in Taipei City of Taiwan between September 2006 and June 2008. Read More

BMC Fam Pract 2019 06 1;20(1):75. Epub 2019 Jun 1.

Department of Otorhinolaryngology, Head and Neck Surgery, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, DK-8200, Aarhus N, Denmark.

Background: The national guideline for sore throat, endorsed by the Danish Society of General Medicine, recommends the use of the modified Centor score and streptococcal rapid antigen detection test to guide diagnosis and treatment of sore throat. The aim was to investigate Danish general practitioners (GPs) routine management of sore throat patients with a focus on the modalities used and adherence to the guideline.

Methods: A cross-sectional study. Read More

J Child Health Care 2019 12 26;23(4):512-521. Epub 2019 May 26.

First Vienna Pediatric Medical Center, Vienna, Austria.

The frequency of consultations and the waiting times in pediatric hospital outpatient clinics are steadily increasing. The aim of this study was to compare the occurrence of patients in a large pediatric group practice and a hospital-based general pediatric outpatient clinic. Primary parameters were the most common reasons for consultation, the waiting times and the reasons for selecting a certain institution. Read More

Rev Chilena Infectol 2019 Feb;36(1):69-77

Servicio de Pediatría, Clínica Alemana de Santiago, Chile.

J Med Case Rep 2019 Apr 24;13(1):104. Epub 2019 Apr 24.

University Department promise "G. D'Alessandro", University of Palermo, Palermo, Italy.

Background: There are reports of the familial occurrence of Kawasaki disease but only a few reports described Kawasaki disease in siblings. However, the familial cases were not simultaneous. In these patients the idea of infective agents as trigger must be considered. Read More

Georgian Med News 2019 Feb(287):51-56

Odessa National Medical University, Ukraine.

Aim - to study the effect of different pathogens (EBV, CMV, HHV-6, and MIXT) on the severity of clinical-paraclinical manifestations of infectious mononucleosis in children. The clinical and laboratory study performed for 410 children aged from 10 months up to 12 years with infectious mononucleosis. The association of herpes viruses, mainly EBV, CMV and HHV type 6, takes part in the formation of the clinical picture of IM in (52,9%) of cases. Read More

BMJ Open 2019 04 3;9(4):e026251. Epub 2019 Apr 3.

Division of General Internal Medicine, Jichi Medical University Hospital, Shimotsuke, Tochigi, Japan.

Objectives: To investigate oral antibiotic prescribing patterns and identify factors associated with antibiotic prescriptions, with the aim of guiding future interventions to reduce inappropriate prescribing.

Design: Retrospective cohort study.

Setting: Database of public health insurance claims in Kumamoto prefecture (Japan). Read More

Pediatr Dermatol 2019 Jul 31;36(4):550-551. Epub 2019 Mar 31.

Department of Dermatology, Children's National Medical Center, Washington, District of Columbia.

A 10-year-old girl, suspected 2 days prior to have streptococcal pharyngitis, presented with diffuse erythema, tense bullae, Nikolsky-positive desquamation, as well as ulcerations of her oral and genital mucosa. She denied recent travel, sick contacts, or preceding and concurrent use of medications, including over-the-counter and herbal supplements. A comprehensive viral polymerase chain reaction (PCR) panel, Mycoplasma pneumoniae PCR and IgM, streptococcal molecular antigen test, urine culture, blood culture, and rheumatologic serologies were negative. Read More