4,367 results match your criteria Pharyngitis Bacterial


Evaluation of the SD Bioline Strep A Ultra Test in Relation With Number of Colony Forming Units and Color Intensity.

Ann Lab Med 2019 Jan;39(1):31-35

Department of Laboratory Medicine, Gyeongsang National University College of Medicine, Jinju, Korea.

Background: The SD Bioline Strep A Ultra (SD, Yongin, Korea) is a recently developed rapid antigen detection test (RADT) for diagnosing bacterial pharyngitis caused by Group A , We evaluated the performance of SD Bioline Strep A Ultra, using the number of colony forming units and color intensity.

Methods: Three throat swabs each were taken from 343 children with pharyngitis who visited pediatric clinics. We evaluated the performance of SD Bioline Strep A Ultra and compared its positive rate with the number of colony forming units, using the Fisher exact test. Read More

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January 2019

[Investigation of Streptococcus pyogenes virulence factors and typing by multiple locus variable number tandem repeat fingerprinting (MLVF) method].

Mikrobiyol Bul 2018 Jul;52(3):233-246

Selçuk University Faculty of Medicine, Department of Medical Microbiology, Konya, Turkey.

Streptococcus pyogenes is an important bacterial pathogen that colonizes the throat and skin of human beings and causes a wide variety of diseases ranging from mild infections like pharyngitis, tonsillitis and impetigo to severe invasive infections such streptococcal toxic shock syndrome, septicemia, and necrotizing fasciitis, and produces a wide variety of virulence factors. The aim of this study was to investigate the antibiotic resistance, virulence genes; [pyrogenic exotoxin genes (speA, C, G, H, I, J, K, L, M, smeZ and ssa), deoxyribonuclease genes (sdaB, spd3, sdc ve sdaD), protease genes (speB, spyCEP ve scpA) and inhibitor genes (mac and sic)] of S.pyogenes strains isolated from throat cultures of patients with symptomatic tonsillo-pharyngitis and typing by multiple locus variable number tandem repeat fingerprinting (MLVF) method. Read More

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July 2018
7 Reads

Fulminant descending mediastinitis secondary to infectious mononucleosis.

Authors:
G W Fuller J N Rao

J Surg Case Rep 2018 Aug 7;2018(8):rjy203. Epub 2018 Aug 7.

Department of Cardiothoracic Surgery, Northern General Hospital, Herries Road, Sheffield, UK.

Descending mediastinitis is a rare, life-threatening condition caused by contiguous spread of oropharyngeal or cervical infection into the mediastinum. Infectious mononucleosis generally results in a self-limited illness characterized by fever, pharyngitis and lymphadenopathy. We present an exceptional case of an 18-year-old with infectious mononucleosis complicated by progressive bacterial superinfection and fulminant descending mediastinitis. Read More

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August 2018
2 Reads

Mycoplasma pneumoniae DNA detection and specific antibody class response in patients from two tertiary care hospitals in tropical Sri Lanka.

J Med Microbiol 2018 Sep 3;67(9):1232-1242. Epub 2018 Aug 3.

1​Department of Medical Microbiology, Faculty of Medicine, University of Kelaniya, Sri Lanka.

Purpose: Respiratory tract infections are a major cause of global morbidity and mortality. Pneumonia is the ninth leading cause of mortality in Sri Lanka. Atypical pathogens cause about one-fifth of community-acquired pneumonia, while Mycoplasma pneumoniae accounts for about 50 %. Read More

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September 2018
4 Reads

Avian trichomonosis mortality events in band-tailed pigeons () in California during winter 2014-2015.

Int J Parasitol Parasites Wildl 2018 Dec 30;7(3):261-267. Epub 2018 Jun 30.

Karen C. Drayer Wildlife Health Center, School of Veterinary Medicine, University of California, Davis, 1089 Veterinary Medicine Drive, Davis, CA, 95616, United States.

Avian trichomonosis is an upper digestive tract disease of birds typically caused by the protozoan parasite . In California (U.S. Read More

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December 2018
1 Read

The Psoriasis Risk Allele Shows Evidence of Association with Chronic or Recurrent Streptococcal Tonsillitis.

Infect Immun 2018 Oct 21;86(10). Epub 2018 Sep 21.

Research Programs Unit, Immunobiology, University of Helsinki, Helsinki, Finland

Pharyngeal tonsillitis is one of the most common upper respiratory tract infections, and group A streptococcus is the most important bacterial pathogen causing it. While most patients experience tonsillitis only rarely, a subset of patients suffers from recurrent or chronic tonsillitis or pharyngitis. The predisposing factors for recurring or chronic forms of this disease are not yet fully understood, but genetic predisposition has been suggested. Read More

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October 2018
1 Read

Lemierre's syndrome and 2016 American College of Physician guidelines for pharyngitis: no to empiric coverage for bacterial pharyngitis. While no role for routine Fusobacterium PCR, keep suspicion for this pathogen.

BMJ Case Rep 2018 Jul 19;2018. Epub 2018 Jul 19.

Department of Internal Medicine, Michigan State University, Sparrow Hospital, East Lansing, Michigan, USA.

An 18-year-old woman presented to clinic with acute pharyngitis with 4/4 Centor criteria. Rapid streptococcal antigen test was negative. The patient, who was allergic to penicillin, was prescribed azithromycin. Read More

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July 2018
7 Reads

Acute rheumatic fever.

Lancet 2018 07 29;392(10142):161-174. Epub 2018 Jun 29.

Heart Institute (InCor), University of São Paulo, Institute for Investigation in Immunology, National Institute of Science and Technology, São Paulo, Brazil.

Acute rheumatic fever is caused by an autoimmune response to throat infection with Streptococcus pyogenes. Cardiac involvement during acute rheumatic fever can result in rheumatic heart disease, which can cause heart failure and premature mortality. Poverty and household overcrowding are associated with an increased prevalence of acute rheumatic fever and rheumatic heart disease, both of which remain a public health problem in many low-income countries. Read More

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July 2018
8 Reads

Neutralization of Streptolysin S-Dependent and Independent Inflammatory Cytokine IL-1β Activity Reduces Pathology During Early Group A Skin Infection.

Front Cell Infect Microbiol 2018 3;8:211. Epub 2018 Jul 3.

Department of Biological Sciences, University of Notre Dame, Notre Dame, IN, United States.

The bacterial pathogen Group A (GAS) has been shown to induce a variety of human diseases ranging in severity from pharyngitis to toxic shock syndrome and necrotizing fasciitis. GAS produces a powerful peptide toxin known as Streptolysin S (SLS). Though long recognized as a potent cytolysin, recent evidence from our lab has shown that SLS-dependent cytotoxicity is mediated through activation of the pro-inflammatory mediators p38 MAPK and NFκB. Read More

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July 2018
3 Reads

Comparison of Alere i Strep A Rapid Molecular Assay With Rapid Antigen Testing and Culture in a Pediatric Outpatient Setting.

Am J Clin Pathol 2018 Jun 19. Epub 2018 Jun 19.

From the Departments of Pathology and Laboratory Medicine, 1Children's Healthcare of Atlanta, Atlanta, GA.

Objectives: Group A Streptococcus (GAS) is the most common bacterial cause of pediatric acute pharyngitis, and its quick identification is important for subsequent treatment. We sought to determine whether molecular GAS-based testing can successfully replace GAS antigen testing and subsequent culture in a pediatric urgent care center.

Methods: We tested 160 patient oropharyngeal samples by a rapid antigen GAS test, the Alere i Strep A test, and throat culture in a pediatric urgent care setting and calculated basic statistical metrics. Read More

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June 2018
12 Reads

Defining Host Responses during Systemic Bacterial Infection through Construction of a Murine Organ Proteome Atlas.

Cell Syst 2018 May 16;6(5):579-592.e4. Epub 2018 May 16.

Department of Pharmacology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA; Center for Microbiome Innovation, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA. Electronic address:

Group A Streptococcus (GAS) remains one of the top 10 deadliest human pathogens worldwide despite its sensitivity to penicillin. Although the most common GAS infection is pharyngitis (strep throat), it also causes life-threatening systemic infections. A series of complex networks between host and pathogen drive invasive infections, which have not been comprehensively mapped. Read More

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May 2018
1 Read

Clinical Impact of a Rapid Streptococcal Antigen Test on Antibiotic Use in Adult Patients.

Diagn Microbiol Infect Dis 2018 Aug 7;91(4):339-344. Epub 2018 Apr 7.

University of New Mexico Health Sciences Center, Albuquerque, New Mexico, United States of America. Electronic address:

Introduction: Adult pharyngitis is rarely attributable to group A streptococci. Utilization of a rapid streptococcal antigen test (RADT) may improve appropriate prescribing for bacterial pharyngitis.

Methods: Clinic 1 performed RADTs with subsequent Group A DNA probe test (GADNA) from November 2014-March 2015 and November 2015-March 2016 while Clinic 2 was the control clinic, then implemented the RADT with a GADNA from November 2015-March 2016. Read More

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August 2018
2 Reads

[Dynamics of staphylococcus aureus antibiotic resistance to fluoroquinolones in vitro in patients with overweight].

Wiad Lek 2018 ;71(2 pt 1):301-305

Department of Therapy and Family Medicine, Faculty of Postgraduate Education and Pre-University Training, Uzhhorod National University, Uzhhorod, Ukraine.

Objective: Introduction:S. aureus is the main pathogen of skin, soft tissue and otorhinolaryngological infections as well as the cause of osteomyelitis, meningitis and endocarditis. In recent years the importance of S. Read More

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January 2018

Provider Variation in Antibiotic Prescribing and Outcomes of Respiratory Tract Infections.

South Med J 2018 04;111(4):235-242

From the Department of Internal Medicine, Medicine Institute, Cleveland Clinic, and the Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, Ohio.

Objectives: Inappropriate antibiotic use for respiratory tract infection (RTI) is an ongoing problem linked to the emergence of drug resistance and other adverse effects. Less is known about the prescribing practices of individual physicians or the impact of physician prescribing habits on patient outcomes. We studied the prescribing practices of providers for acute RTIs in an integrated health system, identified patient factors associated with receipt of an antibiotic and assessed the relation between providers' adjusted prescribing rates and a number of patient outcomes. Read More

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Protective immunity induced by an intranasal multivalent vaccine comprising 10 Lactococcus lactis strains expressing highly prevalent M-protein antigens derived from Group A Streptococcus.

Microbiol Immunol 2018 Jun 11;62(6):395-404. Epub 2018 Jun 11.

Millennium Institute of Immunology and Immunotherapy, Department of Molecular Genetics and Microbiology, Faculty of Biological Sciences, Pontificia Universidad Católica de Chile, Santiago 8331010, Chile.

Streptococcus pyogenes (group A Streptococcus) causes diseases ranging from mild pharyngitis to severe invasive infections. The N-terminal fragment of streptococcal M protein elicits protective antibodies and is an attractive vaccine target. However, this N- terminal fragment is hypervariable: there are more than 200 different M types. Read More

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June 2018
3 Reads

[The specific pathogenetic features of the development of chronic tonsillar pathology].

Vestn Otorinolaringol 2018;83(2):30-33

N.I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation, Moscow, Russia, 117997.

The authors discuss the mechanisms underlying the development of chronic tonsillar pathology confirmed by the methods of histological, autoradiographic, and bacteriological diagnostics. The new aspects of vital activity of microorganisms in the parenchymal tissue of the palatine tonsils are highlighted that account for the low effectiveness of the conservative therapy of chronic tonsillitis and give evidence of the necessity of the surgical treatment of this condition. Read More

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September 2018

Asymptomatic intrathyroidal pyriform sinus fistula mimicking thyroid cancer: A case report and literature review.

Medicine (Baltimore) 2018 Apr;97(16):e0488

Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University Hospital, Seoul, Republic of Korea.

Rationale: There have been many reports of non-thyroidal lesions which can be mistaken for thyroidal lesions on ultrasound (US) examination. However, it is not known that pyriform sinus fistula (PSF) can manifest as an incidental thyroid nodule and cause serious complication on fine-needle aspiration (FNA).

Patient Concerns: We present a 34-year-old man with PSF incidentally detected on US. Read More

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April 2018
16 Reads

How to avoid the inappropriate use of antibiotics in upper respiratory tract infections? A position statement from an expert panel.

Braz J Otorhinolaryngol 2018 May - Jun;84(3):265-279. Epub 2018 Feb 25.

Universidade de São Paulo (USP), Faculdade de Medicina de Ribeirão Preto (FMRP), Departamento de Oftalmologia, Otorrinolaringologia e Cirurgia de Cabeça e Pescoço, Ribeirão Preto, SP, Brazil. Electronic address:

Introduction: Bacterial resistance burden has increased in the past years, mainly due to inappropriate antibiotic use. Recently it has become an urgent public health concern due to its impact on the prolongation of hospitalization, an increase of total cost of treatment and mortality associated with infectious disease. Almost half of the antimicrobial prescriptions in outpatient care visits are prescribed for acute upper respiratory infections, especially rhinosinusitis, otitis media, and pharyngotonsillitis. Read More

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June 2018
10 Reads

Group A Streptococcus pharyngitis and pharyngeal carriage: A meta-analysis.

PLoS Negl Trop Dis 2018 03 19;12(3):e0006335. Epub 2018 Mar 19.

University of Otago Wellington, Newtown, Wellington, New Zealand.

Objective: Antibiotic treatment of Group A Streptococcus (GAS) pharyngitis is important in acute rheumatic fever (ARF) prevention, however clinical guidelines for prescription vary. GAS carriers with acute viral infections may receive antibiotics unnecessarily. This review assessed the prevalence of GAS pharyngitis and carriage in different settings. Read More

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March 2018
3 Reads

Aseptic myonecrosis following intramuscular benzathine penicllin G injection: a novel syndrome.

Diagnosis (Berl) 2017 Mar;4(1):51-54

2Departments of Pediatrics and Medicine, University of Minnesota Medical School, Minneapolis, MN, USA.

We report a novel syndrome of aseptic myonecrosis in a child occurring after intramuscular (IM) benzathine penicillin G injection for the treatment of streptococcal pharyngitis. Common side effects of IM injection, including transient injection site pain and inflammation, are common and well described. However, isolated myonecrosis following IM injection in the pediatric patient has not been previously reported. Read More

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Streptococcal pharyngitis and rheumatic heart disease: the superantigen hypothesis revisited.

Infect Genet Evol 2018 Jul 9;61:160-175. Epub 2018 Mar 9.

Department of Microbiology and Immunology, Western University, London, Canada; Lawson Health Research Institute, London, Canada. Electronic address:

Streptococcus pyogenes is a human-specific and globally prominent bacterial pathogen that despite causing numerous human infections, this bacterium is normally found in an asymptomatic carrier state. This review provides an overview of both bacterial and human factors that likely play an important role in nasopharyngeal colonization and pharyngitis, as well as the development of acute rheumatic fever and rheumatic heart disease. Here we highlight a recently described role for bacterial superantigens in promoting acute nasopharyngeal infection, and discuss how these immune system activating toxins could be crucial to initiate the autoimmune process in rheumatic heart disease. Read More

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July 2018
1 Read

Corticosteroid use in management of pediatric emergency conditions.

Pediatr Emerg Med Pract 2018 Mar 1;15(3):1-16. Epub 2018 Mar 1.

Professor of Emergency Medicine and Pediatrics; Section Chief, Pediatric Emergency Medicine; Medical Director, Upstate Poison Center, Upstate Medical University, Syracuse, NY.

Corticosteroids have been used for over half a century to treat various inflammatory disorders; however, their use in many pediatric conditions remains controversial. This issue reviews evidence on corticosteroid treatment in acute asthma exacerbations, croup, acute pharyngitis, anaphylaxis, acute spinal injury, and bacterial meningitis. While corticosteroids are clearly indicated for management of asthma exacerbations and croup, they are not universally recommended for potential spinal cord injury. Read More

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Corticosteroid use in management of pediatric emergency conditions [digest].

Pediatr Emerg Med Pract 2018 Mar 1;15(3 Suppl):1-2. Epub 2018 Mar 1.

Chief Resident, Emergency Medicine ; Pediatrics, University of Arizona, Tucson, AZ.

Corticosteroids have been used for over half a century to treat various inflammatory disorders; however, their use in many pediatric conditions remains controversial. This issue reviews evidence on corticosteroid treatment in acute asthma exacerbations, croup, acute pharyngitis, anaphylaxis, acute spinal injury, and bacterial meningitis. While corticosteroids are clearly indicated for management of asthma exacerbations and croup, they are not universally recommended for potential spinal cord injury. Read More

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Understanding the gender gap in antibiotic prescribing: a cross-sectional analysis of English primary care.

BMJ Open 2018 02 22;8(2):e020203. Epub 2018 Feb 22.

Modelling and Economics Unit, National Infection Service, Public Health England, London, UK.

Objectives: To explore the causes of the gender gap in antibiotic prescribing, and to determine whether women are more likely than men to receive an antibiotic prescription per consultation.

Design: Cross-sectional analysis of routinely collected electronic medical records from The Health Improvement Network (THIN).

Setting: English primary care. Read More

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February 2018
7 Reads

A 25-Year-Old Male with Orogenital Ulcers, Rash, and Difficulty Swallowing.

Dermatopathology (Basel) 2017 Jan-Dec;4(1-4):7-12. Epub 2017 Nov 8.

Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA.

A 25-year-old otherwise healthy male presented with new-onset odynophagia, rash, and orogenital ulcers. Despite treatment with antibiotics for presumed bacterial pharyngitis, the patient remained symptomatic, with abnormal vital signs and laboratory values. Upon dermatology consultation and histopathologic correlation, he was diagnosed with Behçet disease. Read More

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November 2017

Essential oils from Origanum vulgare and Salvia officinalis exhibit antibacterial and anti-biofilm activities against Streptococcus pyogenes.

Microb Pathog 2018 Apr 13;117:118-127. Epub 2018 Feb 13.

Department of Plant, Food, and Environmental Sciences, Faculty of Agriculture, Dalhousie University, Truro, NS, Canada; Department of Pathology, Faculty of Medicine, Dalhousie University, Halifax, NS, Canada. Electronic address:

In the present study, essential oils (EOs) extracted from oregano, sage, cloves, and ginger were evaluated for the phytochemical profile, antibacterial, and anti-biofilm activities against Streptococcus pyogenes. The broth microdilution method was used to determine the minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) of EOs. The minimum biofilm inhibitory concentrations (MBICs) were determined using MTT assay and fixed biofilms were observed through scan electron microscopy. Read More

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April 2018
13 Reads

How patients' experiences of respiratory tract infections affect healthcare-seeking and antibiotic use: insights from a cross-sectional survey in rural Anhui, China.

BMJ Open 2018 02 3;8(2):e019492. Epub 2018 Feb 3.

School of Health Service Management, Anhui Medical University, Hefei, Anhui, China.

Objective: To investigate the occurrence of reported respiratory tract infection (RTI) symptoms and their effects on use of self and professional care among patients in the community.

Design: A cross-sectional retrospective household survey.

Setting: 12 administrative villages from rural Anhui, China. Read More

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February 2018

Adherence to guidelines for testing and treatment of children with pharyngitis: a retrospective study.

BMC Pediatr 2018 02 9;18(1):43. Epub 2018 Feb 9.

Division of Infectious Diseases, Department of Medicine, Boston Children's Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA, 02115, USA.

Background: Group A streptococcus (GAS) is the most common bacterial etiology of pharyngitis but is difficult to distinguish clinically from viral pharyngitis. There are benefits to early antibacterial treatment of GAS pharyngitis, but administering antibiotics to children with viral pharyngitis is ineffective and costly. We evaluated adherence to guidelines that were developed to help clinicians distinguish between viral and GAS pharyngitis and guide management. Read More

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February 2018

Characterization of the nasopharyngeal and middle ear microbiota in gastroesophageal reflux-prone versus gastroesophageal reflux non-prone children.

Eur J Clin Microbiol Infect Dis 2018 May 5;37(5):851-857. Epub 2018 Feb 5.

Department of Medical Microbiology and Infectious Diseases, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.

Otitis media (OM) is one of the most common pediatric infections worldwide, but the complex microbiology associated with OM is poorly understood. Previous studies have shown an association between OM and gastroesophageal reflux (GER) in children. Therefore, in order to bridge the gap in our current understanding of the interaction between GER and OM, we investigated the nasopharyngeal and middle ear microbiota of children suffering from GER-associated OM and OM only, using culture-independent 16S rRNA gene sequencing. Read More

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Community-Acquired Respiratory Distress Syndrome Toxin Uses a Novel KELED Sequence for Retrograde Transport and Subsequent Cytotoxicity.

MBio 2018 Jan 23;9(1). Epub 2018 Jan 23.

Department of Microbiology, Immunology and Molecular Genetics, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA

is an atypical bacterium that causes respiratory illnesses in humans, including pharyngitis, tracheobronchitis, and community-acquired pneumonia (CAP). It has also been directly linked to reactive airway disease, asthma, and extrapulmonary pathologies. During its colonization, expresses a unique ADP-ribosylating and vacuolating cytotoxin designated ommunity-cquired espiratory istress yndrome (CARDS) toxin. Read More

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January 2018
4 Reads

Deletion of from Streptococcus pyogenes. Results in Hypervirulence in a Mouse Model of Sepsis and is LuxS Independent.

Pol J Microbiol 2017 Mar;66(1):17-24

Center for Molecular and Translational Human Infectious Diseases Research, Houston Methodist Research Institute, and Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, Texas, USA.

Group A Streptococcus (GAS) is a Gram-positive human pathogen that causes a variety of diseases ranging from pharyngitis to life-threatening streptococcal toxic shock syndrome. Recently, several global gene expression analyses have yielded extensive new information regarding the regulation of genes encoding known and putative virulence factors in GAS. A microarray analysis found that transcription of the GAS gene M5005_Spy_1343 was significantly increased in response to interaction with human polymorphonuclear leukocytes. Read More

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March 2017
2 Reads

Analysis of the tonsillar microbiome in young adults with sore throat reveals a high relative abundance of Fusobacterium necrophorum with low diversity.

PLoS One 2018 19;13(1):e0189423. Epub 2018 Jan 19.

Department of Pathology, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America.

Fusobacterium necrophorum (Fn), a gram-negative anaerobe, is increasingly implicated as an etiologic agent in older adolescents and young adults with sore throat. Inadequately treated Fn pharyngitis may result in suppurative complications such as peritonsillar abscess and Lemierre's syndrome. Data from the literature suggest that the incidence of life-threating complications in these age groups from Fn pharyngitis (Lemierre's syndrome) in the United States exceeds those associated with group A beta-hemolytic streptococcal (GAS) pharyngitis (acute rheumatic fever). Read More

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February 2018
10 Reads

Polish Physicians' Attitudes Towards Antibiotic Prescription and Antimicrobial Resistance.

Pol J Microbiol 2017 Sep;66(3):309-319

Department of Epidemiology and Clinical Microbiology, The National Reference Centre for Susceptibility Testing, National Medicines Institute, Warsaw, Poland.

Antimicrobial resistance has been one of the biggest global current issues in medicine and public health. Overuse and imprudent use of antimicrobial agents are recognized as one of the leading causes of antibiotic resistance. The aim of this study was to analyze the attitudes of Polish physicians practicing at the community level towards antibiotics and antimicrobial resistance. Read More

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September 2017

Evaluation of Simplexa Group A Strep Direct Kit Compared to Hologic Group A Streptococcal Direct Assay for Detection of Group A Streptococcus in Throat Swabs.

J Clin Microbiol 2018 Mar 22;56(3). Epub 2018 Feb 22.

Division of Microbiology, Calgary Laboratory Services, University of Calgary, Calgary, Alberta, Canada.

Diagnosis of bacterial pharyngitis is confirmed by detection of group A (GAS) in patient throat samples. Testing of throat samples has historically relied on culture, but new molecular methods allow much faster test turnaround time (i.e. Read More

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March 2018
10 Reads

A 2-year follow-up study of patients with pharyngotonsillitis.

BMC Infect Dis 2018 01 2;18(1). Epub 2018 Jan 2.

Department of Clinical Sciences, Malmö, Family Medicine, Lund University, Lund, Sweden.

Background: Longtime follow-up studies on patients with pharyngotonsillitis are rare. We aimed to describe the patterns of new visits for a sore throat, complications and tonsillectomy during 2 years in a cohort of patients with pharyngotonsillitis and non-infected controls.

Methods: A retrospective chart review was performed on a cohort of patients with acute sore throat (n = 207), and non-infected controls (n = 108). Read More

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January 2018
3 Reads

Antimicrobial treatment of ENT infections.

Arch Pediatr 2017 Dec;24(12S):S9-S16

Groupe de Pathologie Infectieuse Pédiatrique de la Société Française de Pédiatrie, Saint-Maur des Fossés, France; Université Pierre & Marie Curie, Paris 6, France; Service de pédiatrie générale et aval des urgences, Hôpital Armand-Trousseau, Paris, France.

ENT infections are the most common childhood infections and the leading causes of antibiotic prescriptions. These infections are mainly due to viruses and most of them (even if bacterial species are implicated) resolve spontaneously. Therefore, the first message is to not prescribe antibiotics in the following situations: common cold, non-streptococcal pharyngitis, laryngitis, non-purulent otitis media, etc. Read More

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December 2017
4 Reads

Are systemic corticosteroids useful for the management of acute pharyngitis?

Medwave 2017 Dec 26;17(9):e7111. Epub 2017 Dec 26.

Proyecto Epistemonikos, Santiago, Chile; Departamento de Medicina Interna, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile; Centro Evidencia UC, Pontificia Universidad Católica de Chile, Santiago, Chile; GRADE working group; The Cochrane Collaboration. Email: Address: Centro Evidencia UC, Pontificia Universidad Católica de Chile, Centro de Innovación UC Anacleto Angelini, Avda. Vicuña Mackenna 4860, Macul, Santiago, Chile.

Introduction: Pain associated to acute pharyngitis is a frequent cause of consultation. Usual care includes non-steroidal anti-inflammatories and antibiotics in selected cases, but pain relief is not always quick enough. The use of corticosteroids has been proposed as a therapeutic alternative, but its actual efficacy is matter of debate. Read More

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December 2017
4 Reads

Uvular necrosis following diagnostic gastroscopy.

BMJ Case Rep 2017 Dec 20;2017. Epub 2017 Dec 20.

Gastroenterology, Guy's and St Thomas' Hospital, London, UK.

Uvular necrosis is an extremely rare complication of gastroscopy. We describe the fifth published case of uvular necrosis following an uncomplicated diagnostic gastroscopy in a young man. Presentation with severe sore throat and inability to swallow saliva occurred within 24 hours of gastroscopy and resolved with conservative treatment. Read More

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December 2017
1 Read

Subdural empyema caused by Peptostreptococcus sp.: a complication of acute pharyngitis.

Rev Inst Med Trop Sao Paulo 2017 Dec 21;59:e83. Epub 2017 Dec 21.

Tulane University, School of Public Health and Tropical Medicine, New Orleans, United States.

Subdural Empyema (ESD) is the collection of purulent fluid that develops between the exterior "dura mater" layer and the middle "arachnoid mater" layer that covers the brain. ESD can be caused by a primary infection located in the paranasal sinuses. In many aerobic and/or anaerobic bacterial cases, hearing or traumatic processes serve as the causative agent. Read More

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December 2017
4 Reads

Diagnosis and management of group A streptococcal pharyngitis and associated complications [digest].

Pediatr Emerg Med Pract 2017 Dec 21;14(12 Suppl Points & Pearls):1-2. Epub 2017 Dec 21.

Chief Resident, Emergency Medicine & Pediatrics, University of Arizona, Tucson, AZ.

Although group A Streptococcus (GAS) pharyngitis is the most common cause of bacterial pharyngitis in children and adolescents, many viral and bacterial infections mimic the symptoms of GAS pharyngitis. Emergency clinicians must recognize the symptomatology of GAS pharyngitis and use appropriate means of diagnosis and treatment to promote good antibiotic stewardship. This issue reviews the signs and symptoms of GAS pharyngitis, as well as associated complications, and provides recommendations for appropriate treatment that focuses on reducing the severity and duration of symptoms, reducing the incidence of nonsuppurative complications, and reducing transmission. Read More

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December 2017
2 Reads

Association of Broad- vs Narrow-Spectrum Antibiotics With Treatment Failure, Adverse Events, and Quality of Life in Children With Acute Respiratory Tract Infections.

JAMA 2017 12;318(23):2325-2336

Center for Pediatric Clinical Effectiveness, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.

Importance: Acute respiratory tract infections account for the majority of antibiotic exposure in children, and broad-spectrum antibiotic prescribing for acute respiratory tract infections is increasing. It is not clear whether broad-spectrum treatment is associated with improved outcomes compared with narrow-spectrum treatment.

Objective: To compare the effectiveness of broad-spectrum and narrow-spectrum antibiotic treatment for acute respiratory tract infections in children. Read More

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December 2017
12 Reads

Crystalline lens dislocation secondary to bacterial endogenous endophthalmitis.

Am J Ophthalmol Case Rep 2017 Sep 8;7:149-152. Epub 2017 Jul 8.

Department of Ophthalmology, Henry Ford Hospital, 2799 West Grand Blvd, Detroit, MI, United States.

Purpose: To present an unusual case of endogenous endophthalmitis secondary to Group A (GAS) that resulted in dislocation of the crystalline lens.

Observations: An immunocompetent 51-year-old man presented to the emergency room (ER) with upper respiratory infection (URI) symptoms and painful right eye. He was diagnosed with URI and viral conjunctivitis and discharged on oral azithromycin and polytrim eyedrops. Read More

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September 2017
5 Reads

Diagnosis and management of group A streptococcal pharyngitis and associated complications

Pediatr Emerg Med Pract 2017 12 1;14(12):1-20. Epub 2017 Dec 1.

Assistant Professor, Department of Pediatrics and Emergency Medicine, Icahn School of Medicine at Mount Sinai, New York, NY

Although group A Streptococcus (GAS) pharyngitis is the most common cause of bacterial pharyngitis in children and adolescents, many viral and bacterial infections mimic the symptoms of GAS pharyngitis. Emergency clinicians must recognize the symptomatology of GAS pharyngitis and use appropriate means of diagnosis and treatment to promote good antibiotic stewardship. This issue reviews the signs and symptoms of GAS pharyngitis, as well as associated complications, and provides recommendations for appropriate treatment that focuses on reducing the severity and duration of symptoms, reducing the incidence of nonsuppurative complications, and reducing transmission. Read More

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December 2017
2 Reads

Deep neck infections: review of 263 cases.

Otolaryngol Pol 2017 Oct;71(5):37-42

Pauls Stradins Clinical University Hospital, Rīga, Latvia.

Objectives: In patients hospitalized due to deep neck infections (DNIs), to investigate the association between demographic parameters, etiology, and localization of abscesses and/or phlegmons, complications, comorbidities, treatment, and bacterial cultures.

Methods: We analyzed data of 263 patients that were hospitalized from January 1, 2012, to December 31, 2015, due to deep neck space phlegmons and/or abscesses. We performed statistical analysis with the SPSS 22. Read More

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October 2017
5 Reads

Duration of Group A Streptococcus PCR positivity following antibiotic treatment of pharyngitis.

Diagn Microbiol Infect Dis 2018 Feb 12;90(2):105-108. Epub 2017 Oct 12.

Division of Clinical Microbiology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN; Division of Infectious Diseases, Department of Medicine, Mayo Clinic, Rochester, MN.

Background: Polymerase chain reaction (PCR) has high sensitivity and specificity for detection of group A streptococcus (GAS) in throat swabs and is routinely used for GAS pharyngitis diagnosis at our institution. Herein we defined the natural history of throat swab GAS PCR and culture positivity during and following treatment of GAS pharyngitis.

Methods: Fifty children with a PCR positive GAS throat swab were recruited for participation. Read More

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February 2018
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Resolution of recurrent tonsillitis in a non-smoker who became a vaper. A case study and new hypothesis.

Med Hypotheses 2017 Nov 11;109:17-18. Epub 2017 Sep 11.

Wolfson Institute of Preventive Medicine, Queen Mary University of London, 2 Stayner's Road, London E1 4AH, United Kingdom. Electronic address:

Background: Evidence concerning the impact of vaping on respiratory infections remains contradictory. Cell and animal studies suggested that vaping may increase vulnerability to respiratory infections, but human data do not confirm this concern.

Case Presentation: We present a case of a never-smoker who became a vaper and after a few months of e-cigarette use experienced a complete resolution of chronic tonsillitis and a marked improvement in tonsilloliths. Read More

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November 2017