4,455 results match your criteria Pharyngitis Bacterial


Live Usability Testing of Two Complex Clinical Decision Support Tools: Observational Study.

JMIR Hum Factors 2019 Apr 15;6(2):e12471. Epub 2019 Apr 15.

New York University School of Medicine, New York, NY, United States.

Background: Potential of the electronic health records (EHR) and clinical decision support (CDS) systems to improve the practice of medicine has been tempered by poor design and the resulting burden they place on providers. CDS is rarely tested in the real clinical environment. As a result, many tools are hard to use, placing strain on providers and resulting in low adoption rates. Read More

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http://humanfactors.jmir.org/2019/2/e12471/
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http://dx.doi.org/10.2196/12471DOI Listing
April 2019
3 Reads

Bactericidal and Anti-Biofilm Activity of Ethanol Extracts Derived from Selected Medicinal Plants against .

Molecules 2019 Mar 24;24(6). Epub 2019 Mar 24.

Department of Biology, Faculty of Science, Dalhousie University, Halifax, NS B3H 4R2, Canada.

There is a growing interest in medicinal plants which have been traditionally used for the treatment of human infections. This study assessed 14 ethanol extracts (EEs) on bacterial growth and biofilm formation of . Constituent major phytochemicals in the extracts were identified using ultra performance liquid chromatography-electrospray ionization-tandem mass spectrometry (UPLC-ESI-MS/MS). Read More

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https://www.mdpi.com/1420-3049/24/6/1165
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http://dx.doi.org/10.3390/molecules24061165DOI Listing
March 2019
3 Reads

Life-threating complication of parapharyngeal abscess and mediastinitis in a 10-year-old otherwise healthy girl following elective tonsillectomy - first reported paediatric case.

J Laryngol Otol 2019 Feb;133(2):161-163

Department of Oto-rhino-laryngology - Head and Neck Surgery,Copenhagen University Hospital,Denmark.

Background: Parapharyngeal abscess and mediastinitis are rare but very severe post-operative complications following an elective tonsillectomy. Parapharyngeal abscess as a complication to tonsilectomy is very seldom described in the literature and no cases in the paediatric population have been described.Case reportThis paper presents, to our knowledge, the first case of life-threatening parapharyngeal abscess and mediastinitis following elective adenotonsillectomy in an otherwise healthy, fully vaccinated 10-year-old girl. Read More

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http://dx.doi.org/10.1017/S0022215119000021DOI Listing
February 2019
1 Read

Crucial Role of Nucleic Acid Sensing via Endosomal Toll-Like Receptors for the Defense of and .

Front Immunol 2019 21;10:198. Epub 2019 Feb 21.

Department of Infectious Diseases, Medical Microbiology and Hygiene, Heidelberg University Hospital, Heidelberg, Germany.

is a major human pathogen causing a variety of diseases ranging from common pharyngitis to life-threatening soft tissue infections and sepsis. Microbial nucleic acids, especially bacterial RNA, have recently been recognized as a major group of pathogen-associated molecular patterns (PAMPs) involved in the detection of via endosomal Toll-like receptors (TLRs) . However, the individual contribution and cooperation between TLRs as well as cell-type and strain specific differences in dependency on nucleic acid detection during infection have not been clarified in detail. Read More

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http://dx.doi.org/10.3389/fimmu.2019.00198DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394247PMC
February 2019
1 Read

WITHDRAWN: Antistreptococcal interventions for guttate and chronic plaque psoriasis.

Cochrane Database Syst Rev 2019 03 6;3:CD001976. Epub 2019 Mar 6.

Royal Blackburn Hospital, Haslingden Road, Blackburn, UK, BB2 3HH.

Background: Guttate psoriasis is a distinctive acute form of psoriasis which characteristically occurs in children and young adults. It is closely associated with preceding streptococcal sore throat or tonsillitis. Some authorities have claimed that ordinary (chronic plaque) psoriasis may also be made worse by infection at distant sites. Read More

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http://doi.wiley.com/10.1002/14651858.CD001976.pub2
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http://dx.doi.org/10.1002/14651858.CD001976.pub2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402274PMC
March 2019
9 Reads

Diagnosis and Management of Group a Streptococcal Pharyngitis in the United States, 2011-2015.

BMC Infect Dis 2019 Feb 26;19(1):193. Epub 2019 Feb 26.

Primary Care Innovations Lab, Department of Family Medicine, UW Northgate Clinic, University of Washington, Box 354696, 314 NE Thornton Place, Seattle, WA, 98195, USA.

Background: Clinical guidelines for the diagnosis of group A streptococcal (GAS) pharyngitis recommend the use of a rapid antigen detection test (RADT) and/or bacterial culture. This study evaluated the overall diagnosis and treatment of acute pharyngitis in the United States, including predictors of test type and antibiotic prescription.

Methods: A retrospective analysis of pharyngitis events from 2011 through 2015 was conducted using the MarketScan commercial/Medicare databases. Read More

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https://bmcinfectdis.biomedcentral.com/articles/10.1186/s128
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http://dx.doi.org/10.1186/s12879-019-3835-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390592PMC
February 2019
4 Reads

Antagonistic effects of Streptococcus and Lactobacillus probiotics in pharyngeal biofilms.

Lett Appl Microbiol 2019 Apr 13;68(4):303-312. Epub 2019 Mar 13.

Division of Pharmacy and Optometry, School of Health Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.

Direct antagonism towards pathogens including Streptococcus pyogenes is a proposed mechanism of pharyngeal probiosis but off-target effects on the symbiotic microbiota of the throat are possible and may be beneficial, harmful or neutral. We have assessed the bacteriological effects of two candidate Lactobacillus probiotics and the established pharyngeal probiotic Streptococcus salivarius K12. Antagonism towards S. Read More

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http://dx.doi.org/10.1111/lam.13133DOI Listing

Improving pediatric emergency department physicians' adherence to clinical practice guidelines on the diagnosis and management of group A beta-hemolytic streptococcal pharyngitis-a cross-sectional study.

Int J Emerg Med 2018 16;11:49. Epub 2018 Nov 16.

4Department of Pediatric Emergency, College of Medicine, King Saud bin Abdulaziz University for Health Sciences (KSAUHS), Riyadh, Saudi Arabia.

Introduction: Pharyngitis is one of the major and commonly seen presentations in pediatric emergency departments. While it could be caused by both bacterial and viral pathogens, antibiotics are improperly prescribed regardless of the pathogen. Inappropriate usage of antibiotics has risen the concern of microbial resistance and the need for stricter guidelines. Read More

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http://dx.doi.org/10.1186/s12245-018-0209-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326116PMC
November 2018
9 Reads

Safety of Percutaneous Hepatic Perfusion with Melphalan in Patients with Unresectable Liver Metastases from Ocular Melanoma Using the Delcath Systems' Second-Generation Hemofiltration System: A Prospective Non-randomized Phase II Trial.

Cardiovasc Intervent Radiol 2019 Feb 14. Epub 2019 Feb 14.

Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands.

Purpose: To investigate the safety and toxicity of percutaneous hepatic perfusion with melphalan (M-PHP) with the Delcath Systems' second-generation (GEN 2) filter and compare the outcomes with historical data from studies using the first-generation filter.

Materials And Methods: A prospective, single-arm, single-center phase II study was carried out including 35 patients with unresectable, histologically confirmed liver metastases from ocular melanoma between February 2014 and June 2017. Main exclusion criteria were extrahepatic disease and age > 75 years. Read More

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http://dx.doi.org/10.1007/s00270-019-02177-xDOI Listing
February 2019
1 Read

A Controlled Human Infection Model of Group A Pharyngitis: Which Strain and Why?

mSphere 2019 02 13;4(1). Epub 2019 Feb 13.

Tropical Diseases, Murdoch Children's Research Institute, Melbourne, Victoria, Australia

Group A (GAS) is a major cause of global infection-related morbidity and mortality. A modern controlled human infection model (CHIM) of GAS pharyngitis can accelerate vaccine development and pathogenesis research. A robust rationale for strain selection is central to meeting ethical, scientific, and regulatory requirements. Read More

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http://dx.doi.org/10.1128/mSphere.00647-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374595PMC
February 2019
2 Reads

Acute Non-Rheumatic Myopericarditis: A Rare Complication of Pharyngitis.

Eur J Case Rep Intern Med 2018 27;5(12):000987. Epub 2018 Dec 27.

Serviço de Cardiologia, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal.

Acute non-rheumatic streptococcal myopericarditis (ANRSM) is a rare complication of an upper airway infection by streptococcus group A in developed countries. Cardiac involvement in bacterial infections must be adequately treated because it can lead to long-term complications. This case report describes recurrent ANRSM in an 18-year-old man, which illustrates how difficult and challenging the diagnosis of this disease can be. Read More

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http://dx.doi.org/10.12890/2018_000987DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346973PMC
December 2018
1 Read

utilizes both Phospholipase D and Arcanolysin to mediate its uptake into non-phagocytic cells.

Infect Immun 2019 Feb 11. Epub 2019 Feb 11.

Department of Microbiology and Immunology, Louisiana State University Health Sciences Center - Shreveport, 1501 Kings Highway P.O. Box 33932, Shreveport, LA 71130-3932, USA

is an emerging human pathogen that causes pharyngitis and wound infections. A few studies have suggested that is able to induce its uptake into non-phagocytic epithelial cells, but the bacterial factors associated with host-cell invasion and the host-cell processes involved have yet to be studied. We investigated how two virulence factors, arcanolysin and phospholipase D, affect the ability of the bacteria to adhere to and subsequently invade Detroit 562 pharyngeal epithelial cells. Read More

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http://dx.doi.org/10.1128/IAI.00832-18DOI Listing
February 2019
1 Read

Antibiotic management of acute pharyngitis in primary care.

Hong Kong Med J 2019 Feb 31;25(1):58-63. Epub 2019 Jan 31.

Hong Kong Sanatorium & Hospital, Hong Kong.

The Centre for Health Protection of the Department of Health has convened the Advisory Group on Antibiotic Stewardship Programme in Primary Care (the Advisory Group) to formulate guidance notes and strategies for optimising judicious use of antibiotics and enhancing the Antibiotic Stewardship Programme in Primary Care. Acute pharyngitis is one of the most common conditions among out-patients in primary care in Hong Kong. Practical recommendations on the diagnosis and antibiotic treatment of acute streptococcal pharyngitis are made by the Advisory Group based on the best available clinical evidence, local prevalence of pathogens and associated antibiotic susceptibility profiles, and common local practice. Read More

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http://dx.doi.org/10.12809/hkmj187544DOI Listing
February 2019
1 Read

Antibiotic therapy for an ENT specialist.

Authors:
Piotr Albrecht

Otolaryngol Pol 2018 Sep;72(6):1-9

Klinika Gastroenterologii i Żywienia Dzieci, Warszawski Uniwersytet Medyczny, Warszawa, Polska.

The study dedicated mainly to general practitioners of ENTs discusses the principles of antibiotic therapy of the most common diseases that this specialty deals with, namely acute tonsillitis and throat inflammation, acute otitis media (AOM), and acute sinusitis. The most common errors in the antibiotic therapy of these diseases are also presented. The basic antibiotic in streptococcal pharyngitis is and remains oral penicillin administered for 10 days. Read More

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http://dx.doi.org/10.5604/01.3001.0012.4704DOI Listing
September 2018
16 Reads

Water Extract Shows Potential in Suppressing Pathogens, Lipopolysaccharide-Induced Inflammation and Oxidative Stress-Induced Cell Injury.

Molecules 2019 Jan 12;24(2). Epub 2019 Jan 12.

Tea Research Institute Chinese Academy of Agricultural Sciences, Ministry of Agriculture, Hangzhou 310008, China.

is traditionally used to prevent inflammatory diseases such as periodontitis and pharyngitis by residents in southwest China. However, little scientific evidence has been found to support this. In this research, the antibacterial activities of water extract (CLE) were assessed using the micro-dilution method. Read More

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http://www.mdpi.com/1420-3049/24/2/273
Publisher Site
http://dx.doi.org/10.3390/molecules24020273DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359260PMC
January 2019
13 Reads

Grisel syndrome presenting as hemiplegia in a patient with multifocal sepsis.

Malawi Med J 2018 06;30(2):127-131

Consultant Trauma and Orthopaedic Surgeon; Dean of Faculty of Medicine, College of Medicine, University of Malawi.

Introduction: Grisel syndrome is a non-traumatic rotary subluxation of C1 on C2 (atlantoaxial subluxation). It is a rare condition predominantly described in paediatric population with previous history of upper respiratory infections orotolaryngeal procedures. The diagnosis is established by the association of clinical and radiologic findings4,6. Read More

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http://dx.doi.org/10.4314/mmj.v30i2.13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307069PMC
June 2018
6 Reads

Spectrum of bactericidal action of amylmetacresol/2,4-dichlorobenzyl alcohol lozenges against oropharyngeal organisms implicated in pharyngitis.

Int J Gen Med 2018 28;11:451-456. Epub 2018 Nov 28.

Reckitt Benckiser Healthcare International Ltd, Slough, Berkshire, UK,

Purpose: Pharyngitis is commonly caused by a self-limiting upper respiratory tract infection (URTI) and symptoms typically include sore throat. Antibiotics are often inappropriately used for the treatment of pharyngitis, which can contribute to antimicrobial resistance, therefore non-antibiotic treatments which have broad antiseptic effects may be more appropriate. Amylmetacresol (AMC) and 2,4-dichlorobenzyl alcohol (DCBA) are present in some antiseptic lozenges and have established benefits in providing symptomatic relief and some in vitro antiviral action. Read More

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http://dx.doi.org/10.2147/IJGM.S184406DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276617PMC
November 2018
17 Reads

Unusual case of Lemierre's syndrome.

BMJ Case Rep 2018 Nov 28;11(1). Epub 2018 Nov 28.

Infectious diseases, Hospital for Tropical Diseases, London, UK.

A young previously healthy patient presented with sepsis and cavitating pneumonia. was isolated from blood cultures and subsequent CT neck showed an internal jugular vein thrombosis. Treatment was with antibiotics, anticoagulation and supportive management. Read More

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http://dx.doi.org/10.1136/bcr-2018-226948DOI Listing
November 2018
3 Reads

Elastic recovery of filler-binders to safeguard viability of Lactobacillus rhamnosus GG during direct compression.

Eur J Pharm Biopharm 2019 Feb 10;135:36-43. Epub 2018 Dec 10.

University of Antwerp, Department of Pharmaceutical, Biomedical and Veterinary Sciences, Laboratory of Pharmaceutical Technology and Biopharmacy, Universiteitsplein 1, B-2610 Wilrijk, Belgium. Electronic address:

Tablets are increasingly explored as dosage form for oral probiotics, especially for applications such as pharyngitis and dental health. In such tablets, the dry form increases the stability and the shelf life of the product. In addition, the probiotic cells are entrapped in the tablet matrix, which protects them against the environmental factors in the human body. Read More

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http://dx.doi.org/10.1016/j.ejpb.2018.12.005DOI Listing
February 2019
4 Reads

Multicenter Clinical Evaluation of the Automated Aries Group A Strep PCR Assay from Throat Swabs.

J Clin Microbiol 2019 Feb 30;57(2). Epub 2019 Jan 30.

Department of Pathology and Laboratory Medicine, Children's Mercy Hospital and Clinics, Kansas City, Missouri, USA

Group A (GAS) is one of the leading causes of bacterial pharyngitis. Early GAS diagnosis is critical for appropriate antibiotic administration that reduces the risk of GAS sequelae and limits spread of the infection. The Aries Group A Strep (GAS) assay (Luminex, Austin, TX) is a fully automated PCR assay for direct detection of GAS in throat swab specimens in less than 2 h with minimum hands-on time. Read More

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http://dx.doi.org/10.1128/JCM.01482-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355539PMC
February 2019
10 Reads

Infections of the Oropharynx.

Authors:
Matthew R Klein

Emerg Med Clin North Am 2019 Feb;37(1):69-80

Department of Emergency Medicine, Northwestern University, 211 East Ontario - Suite 300, Chicago, IL 60611, USA. Electronic address:

This article reviews the presentation, diagnosis, and management of common and "can't miss" infections of the oropharynx, including streptococcal pharyngitis, infectious mononucleosis, peritonsillar abscess, retropharyngeal abscess, and epiglottitis. Read More

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http://dx.doi.org/10.1016/j.emc.2018.09.002DOI Listing
February 2019
5 Reads

[Study on the super-antigen genes of group A strains isolated from patients with scarlet fever and pharyngeal infection, in Beijing, 2015-2017].

Zhonghua Liu Xing Bing Xue Za Zhi 2018 Oct;39(10):1375-1380

Beijing Municipal Center for Disease Control and Prevention, Beijing Research Center for Preventive Medicine, Beijing 100013, China.

To analyze the characteristics of super-antigen (SAg) of group A (GAS), isolated from patients with scarlet fever or pharyngeal infections in Beijing between 2015-2017. Throat swab specimens from patients with scarlet fever or pharyngeal infections were collected and tested for GAS. Eleven currently known SAg genes including ACGHIJ, KLMZ and were tested by real-time PCR while M protein genes ( genes) were amplified and sequenced by PCR. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0254-6450.2018.10.016DOI Listing
October 2018
3 Reads

Pleomorphic adenoma of the head and neck in children: presentation and management.

Laryngoscope 2018 Nov 15. Epub 2018 Nov 15.

Department of Otolaryngology and Communication Enhancement, Boston, Massachusetts, U.S.A.

Objective: Pleomorphic adenoma is the most common benign salivary gland neoplasm in children. Recurrence and malignant transformation are concerns necessitating proper treatment. The goal of this research was to discuss the presentation, evaluation, and management of pediatric pleomorphic adenoma of the head and neck. Read More

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http://doi.wiley.com/10.1002/lary.27590
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http://dx.doi.org/10.1002/lary.27590DOI Listing
November 2018
25 Reads

Knowledge of pharmacists and parents towards antibiotic use in pediatrics: a cross-sectional study in Lebanon.

Pharm Pract (Granada) 2018 Jul-Sep;16(3):1194. Epub 2018 Aug 12.

Faculty of Pharmacy & Faculty of Public Health, Lebanese University, Hadat (Lebanon).

Objectives: to assess the knowledge of both parents and community pharmacists regarding antibiotics use and resistance in pediatrics in Lebanon.

Methods: A cross-sectional study was conducted between June and August 2017 in community pharmacies. A pre-established questionnaire targeting knowledge of parents and pharmacists regarding antibiotics use/misuse was carried out. Read More

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https://www.pharmacypractice.org/journal/index.php/pp/articl
Publisher Site
http://dx.doi.org/10.18549/PharmPract.2018.03.1194DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6207355PMC
August 2018
11 Reads

Lemierre's Syndrome.

Oman Med J 2018 Nov;33(6):523-526

Radiology Department, Khoula Hospital, Muscat, Oman.

Lemierre's syndrome is a rare, life-threatening condition, which may be fatal if not properly treated. This disease refers to thrombophlebitis of the internal jugular vein, which is the result of bacterial sore throat infection (usually in the form of pharyngitis) that extends into the parapharyngeal space. However, it can result from other infective foci in the ear, nose, parotid glands, and paranasal sinuses. Read More

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http://dx.doi.org/10.5001/omj.2018.95DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6206425PMC
November 2018
6 Reads

The use of rapid antigen testing and matrix-assisted laser desorption/ionization-time of flight mass spectrometry in the diagnosis of group A beta-hemolytic streptococci in throat swab samples

Turk J Med Sci 2018 Oct 31;48(5):939-944. Epub 2018 Oct 31.

Background/aim: We aimed to evaluate the efficacy of a rapid antigen test in detecting group A beta-hemolytic streptococci (GAS) in throat samples in comparison with the culture method and to compare the efficiency of matrix-assisted laser desorption/ionization-time of flight mass spectrometry (MALDI-TOF MS) and traditional methods in identifying GAS in cultures. Materials and methods: A total of 3668 throat samples from patients with a prediagnosis of tonsillopharyngitis were assessed by the QuickVue+Strep A antigen test and culture. For GAS identification from cultures, bacitracin sensitivity, PYR, and latex agglutination tests and MALDI-TOF MS were used. Read More

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http://dx.doi.org/10.3906/sag-1712-101DOI Listing
October 2018
2 Reads

Management of Pharyngitis.

Authors:
Jonathan Berkley

Circulation 2018 Oct;138(18):1920-1922

Kupat Holim Meuhedet, Jerusalem District, Israel.

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https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.118.0
Publisher Site
http://dx.doi.org/10.1161/CIRCULATIONAHA.118.035900DOI Listing
October 2018
18 Reads

Parapharyngeal Abscesses Caused by Group G Streptococcus.

Case Rep Otolaryngol 2018 27;2018:7307290. Epub 2018 Sep 27.

Department of Otorhinolaryngology, Juntendo University Faculty of Medicine, Tokyo, Japan.

Deep neck abscess is a life-threatening infection that causes laryngeal edema and upper airway occlusion. The predominant bacterial species involved in this disorder is group A streptococcus. Group G streptococcus (GGS) constitutes the normal commensal flora of the human upper airway. Read More

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https://www.hindawi.com/journals/criot/2018/7307290/
Publisher Site
http://dx.doi.org/10.1155/2018/7307290DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6181002PMC
September 2018
18 Reads

A Lot to Choke on: Case of Adult Epiglottitis with Concurrent Peritonsillar Abscess in a Patient with a Sore Throat.

J Emerg Med 2018 Dec 17;55(6):841-844. Epub 2018 Oct 17.

University of California San Diego, San Diego, California.

Background: In the winter months, one often sees a large increase in the volume of patients presenting to emergency departments with acute pharyngitis. While most cases of acute pharyngitis are benign, a rare minority can be life threatening.

Case Report: We report a case of epiglottis with a concomitant peritonsillar abscess (PTA) in an adult who presented to the emergency department with a sore throat. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07364679183093
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http://dx.doi.org/10.1016/j.jemermed.2018.09.017DOI Listing
December 2018
27 Reads

Urgent Infections of the Head and Neck.

Med Clin North Am 2018 Nov 20;102(6):1109-1120. Epub 2018 Sep 20.

Otolaryngology-Head and Neck Surgery, University of California, San Francisco, 2233 Post Street, 3rd floor, San Francisco, CA 94115, USA.

Infections of the head and neck are common and appropriately managed by primary care providers in most cases. However, some infections are associated with significant morbidity and require urgent recognition and management by specialty services. These include deep neck space infections originating in the oral cavity, pharynx, and salivary glands, as well as complicated otologic and sinonasal infection. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00257125183007
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http://dx.doi.org/10.1016/j.mcna.2018.06.015DOI Listing
November 2018
15 Reads

Real-time PCR investigation of the prevalence of Fusobacterium necrophorum in patients with pharyngitis in Japan.

J Infect Chemother 2018 Dec 11;24(12):969-974. Epub 2018 Oct 11.

Disease Control and Prevention Center, National Center for Global Health and Medicine, 1-21-1 Toyama, Shinjuku-ku, Tokyo, 162-8655, Japan.

Purpose: Recent data suggest an association between Fusobacterium necrophorum infection and pharyngotonsillitis among adolescents and adults. However, existing reports are only from North America and Europe. We aimed to identify and compare the prevalence of F. Read More

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http://dx.doi.org/10.1016/j.jiac.2018.09.008DOI Listing
December 2018
4 Reads

Miliary tuberculosis and herpes pharyngitis after a trip to a developing country: dangers of biologics.

BMJ Case Rep 2018 Oct 2;2018. Epub 2018 Oct 2.

Internal Medicine, Cooper University Hospital, Camden, New Jersey, USA.

The use of biologic drugs has expanded since its introduction in the late 1990s. With growing medical use and newer biologic drugs in development, opportunistic infections like remain important adverse effects. It carries major public health concerns, yet evidence-based clinical guidelines for more routine interval screening in patients taking immunosuppressants and exposed to tuberculosis (TB) are lacking. Read More

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http://dx.doi.org/10.1136/bcr-2018-224459DOI Listing
October 2018
10 Reads

Molecular analysis of Streptococcus pyogenes strains isolated from patients with recurrent pharyngitis after oral amoxicillin treatment.

J Med Microbiol 2018 Nov 24;67(11):1544-1550. Epub 2018 Sep 24.

2​Department of Bacteriology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, Fukuoka 812-8582, Japan.

Purpose: The most common illness caused by Streptococcus pyogenes (Group A streptococcus; GAS) is acute pharyngitis. It has been reported that a small percentage of patients experience recurrent GAS pharyngitis after 10 days of treatment with oral amoxicillin. The aim of this study was to clarify whether recurrent GAS pharyngitis is reactivation caused by the primary strain remaining at the infection site, or if the reinfection is caused by newly acquired strains. Read More

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http://dx.doi.org/10.1099/jmm.0.000833DOI Listing
November 2018
2 Reads

Place of phytotherapy in the treatment of acute infections of upper respiratory tract and upper gastrointestinal tract.

Otolaryngol Pol 2018 Aug;72(4):42-50

Studenckie Koło Naukowe przy Klinice Otolaryngologii i Laryngologii Onkologicznej, Uniwersytet Medyczny w Łodzi.

Acute infections of the upper respiratory tract and upper gastrointestinal tract (mouth and throat) are still the most common reason for reporting to the general practitioner or ENT specialist. Despite the fact that the most common causative agent of these diseases is a virus, antibiotics are still flavored in about 60-80% of patients who report to the doctor. In consensuses such as EPOS, WHO reports and other local/ / national reports, there is a need to limit antibacterial treatment for and to replace it with symptomatic and anti-inflammatory drugs. Read More

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http://dx.doi.org/10.5604/01.3001.0012.2833DOI Listing
August 2018
11 Reads

Evaluation of the SD Bioline Strep A Ultra Test in Relation With Number of Colony Forming Units and Color Intensity.

Ann Lab Med 2019 Jan;39(1):31-35

Department of Laboratory Medicine, Gyeongsang National University College of Medicine, Jinju, Korea.

Background: The SD Bioline Strep A Ultra (SD, Yongin, Korea) is a recently developed rapid antigen detection test (RADT) for diagnosing bacterial pharyngitis caused by Group A , We evaluated the performance of SD Bioline Strep A Ultra, using the number of colony forming units and color intensity.

Methods: Three throat swabs each were taken from 343 children with pharyngitis who visited pediatric clinics. We evaluated the performance of SD Bioline Strep A Ultra and compared its positive rate with the number of colony forming units, using the Fisher exact test. Read More

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http://dx.doi.org/10.3343/alm.2019.39.1.31DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6143457PMC
January 2019
3 Reads

Streptococcus pyogenes CAMP factor promotes calcium ion uptake in RAW264.7 cells.

Microbiol Immunol 2018 Oct;62(10):617-623

Division of Microbiology and Infectious Diseases, Graduate School of Medical and Dental Sciences, Niigata University, 2-5274 Gakkocho-dori, Chuo-ku, Niigata 951-8514, Japan.

Streptococcus pyogenes is a bacterium that causes systemic diseases such as pharyngitis and toxic shock syndrome. S. pyogenes produces molecules that inhibit the function of the human immune system, thus allowing growth and spread of the pathogen in tissues. Read More

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http://dx.doi.org/10.1111/1348-0421.12647DOI Listing
October 2018
6 Reads

Variability in Antibiotic Prescribing for Upper Respiratory Illnesses by Provider Specialty.

J Pediatr 2018 12 5;203:76-85.e8. Epub 2018 Sep 5.

Tufts Medical Center, Division of Geographic Medicine and Infectious Diseases, Boston, MA; Tufts University School of Medicine, Boston, MA.

Objective: To evaluate variation in antibiotic prescribing between pediatric and nonpediatric providers for common upper respiratory illnesses.

Study Design: Patient encounters for children aged <18 years from a regional health care system were identified. Electronic medical records from 2011 to 2016 were extracted for diagnoses of upper respiratory infection, pharyngitis, acute otitis media, and sinusitis. Read More

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http://dx.doi.org/10.1016/j.jpeds.2018.07.044DOI Listing
December 2018
6 Reads

Confluent Retropharyngeal, Lateral Pharyngeal, and Peritonsilar MRSA Abscess in an Infant.

Pediatr Emerg Care 2018 Sep;34(9):e161-e164

Division of Pediatric Emergency Medicine, Department of Pediatrics, Hamad Medical Corporation.

Neck abscesses such as retropharyngeal, peritonsilar, and lateral pharyngeal are well described, typically cause a characteristic illness, and have a known epidemiology. We present a rare occurrence of case of confluent, mixed retropharyngeal, lateral pharyngeal, and peritonsilar abscess in a 9-month-old female infant. The symptoms at presentation were very mild and not expected in association with this extensive an abscess. Read More

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http://dx.doi.org/10.1097/PEC.0000000000001601DOI Listing
September 2018
5 Reads

Paired analysis of the microbiota between surface tissue swabs and biopsies from pediatric patients undergoing adenotonsillectomy.

Int J Pediatr Otorhinolaryngol 2018 Oct 19;113:51-57. Epub 2018 Jul 19.

Department of Surgery, The University of Auckland, Auckland, New Zealand.

Introduction: Culture-independent methods, based on bacterial 16 S rRNA gene sequencing, have been used previously to investigate the adenotonsillar microbiota. However, these studies have focused on a single sampling site (usually a surface swab). We aimed to investigate potential differences in adenotonsillar microbiota according to sampling location, both on and within the adenoids and palatine tonsils. Read More

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http://dx.doi.org/10.1016/j.ijporl.2018.07.024DOI Listing
October 2018
2 Reads

The bacterial community and local lymphocyte response are markedly different in patients with recurrent tonsillitis compared to obstructive sleep apnoea.

Int J Pediatr Otorhinolaryngol 2018 Oct 26;113:281-288. Epub 2018 Jul 26.

Department of Surgery, The University of Auckland, Auckland, New Zealand.

Introduction: Obstructive sleep apnea (OSA) is now a more common indication for tonsillectomy than recurrent tonsillitis (RT) [1,2]. Few studies have addressed possible differences in pathogenesis between these two conditions. Children with RT and OSA are often being treated in the community with multiple courses of antibiotics before surgery. Read More

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http://dx.doi.org/10.1016/j.ijporl.2018.07.041DOI Listing
October 2018
14 Reads

[Investigation of Streptococcus pyogenes virulence factors and typing by multiple locus variable number tandem repeat fingerprinting (MLVF) method].

Mikrobiyol Bul 2018 Jul;52(3):233-246

Selçuk University Faculty of Medicine, Department of Medical Microbiology, Konya, Turkey.

Streptococcus pyogenes is an important bacterial pathogen that colonizes the throat and skin of human beings and causes a wide variety of diseases ranging from mild infections like pharyngitis, tonsillitis and impetigo to severe invasive infections such streptococcal toxic shock syndrome, septicemia, and necrotizing fasciitis, and produces a wide variety of virulence factors. The aim of this study was to investigate the antibiotic resistance, virulence genes; [pyrogenic exotoxin genes (speA, C, G, H, I, J, K, L, M, smeZ and ssa), deoxyribonuclease genes (sdaB, spd3, sdc ve sdaD), protease genes (speB, spyCEP ve scpA) and inhibitor genes (mac and sic)] of S.pyogenes strains isolated from throat cultures of patients with symptomatic tonsillo-pharyngitis and typing by multiple locus variable number tandem repeat fingerprinting (MLVF) method. Read More

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http://www.mikrobiyolbul.org/linkout.aspx?pmid=30156510
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http://dx.doi.org/10.5578/mb.66841DOI Listing
July 2018
18 Reads

RocA Has Serotype-Specific Gene Regulatory and Pathogenesis Activities in Serotype M28 Group A Streptococcus.

Infect Immun 2018 11 25;86(11). Epub 2018 Oct 25.

Center for Molecular and Translational Human Infectious Diseases Research, Department of Pathology and Genomic Medicine, Houston Methodist Research Institute and Houston Methodist Hospital, Houston, Texas, USA

Serotype M28 group A streptococcus (GAS) is a common cause of infections such as pharyngitis ("strep throat") and necrotizing fasciitis ("flesh-eating" disease). Relatively little is known about the molecular mechanisms underpinning M28 GAS pathogenesis. Whole-genome sequencing studies of M28 GAS strains recovered from patients with invasive infections found an unexpectedly high number of missense (amino acid-changing) and nonsense (protein-truncating) polymorphisms in (egulator f ov), leading us to hypothesize that altered RocA activity contributes to M28 GAS molecular pathogenesis. Read More

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http://dx.doi.org/10.1128/IAI.00467-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6204712PMC
November 2018
3 Reads
3.731 Impact Factor

Fulminant descending mediastinitis secondary to infectious mononucleosis.

Authors:
G W Fuller J N Rao

J Surg Case Rep 2018 Aug 7;2018(8):rjy203. Epub 2018 Aug 7.

Department of Cardiothoracic Surgery, Northern General Hospital, Herries Road, Sheffield, UK.

Descending mediastinitis is a rare, life-threatening condition caused by contiguous spread of oropharyngeal or cervical infection into the mediastinum. Infectious mononucleosis generally results in a self-limited illness characterized by fever, pharyngitis and lymphadenopathy. We present an exceptional case of an 18-year-old with infectious mononucleosis complicated by progressive bacterial superinfection and fulminant descending mediastinitis. Read More

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http://dx.doi.org/10.1093/jscr/rjy203DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6080047PMC
August 2018
3 Reads

Mycoplasma pneumoniae DNA detection and specific antibody class response in patients from two tertiary care hospitals in tropical Sri Lanka.

J Med Microbiol 2018 Sep 3;67(9):1232-1242. Epub 2018 Aug 3.

1​Department of Medical Microbiology, Faculty of Medicine, University of Kelaniya, Sri Lanka.

Purpose: Respiratory tract infections are a major cause of global morbidity and mortality. Pneumonia is the ninth leading cause of mortality in Sri Lanka. Atypical pathogens cause about one-fifth of community-acquired pneumonia, while Mycoplasma pneumoniae accounts for about 50 %. Read More

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http://dx.doi.org/10.1099/jmm.0.000813DOI Listing
September 2018
16 Reads

Avian trichomonosis mortality events in band-tailed pigeons () in California during winter 2014-2015.

Int J Parasitol Parasites Wildl 2018 Dec 30;7(3):261-267. Epub 2018 Jun 30.

Karen C. Drayer Wildlife Health Center, School of Veterinary Medicine, University of California, Davis, 1089 Veterinary Medicine Drive, Davis, CA, 95616, United States.

Avian trichomonosis is an upper digestive tract disease of birds typically caused by the protozoan parasite . In California (U.S. Read More

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http://dx.doi.org/10.1016/j.ijppaw.2018.06.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6068076PMC
December 2018
2 Reads

Recurrent invasive group A streptococcal infection with four-limb amputation in an immunocompetent child.

BMJ Case Rep 2018 Jul 30;2018. Epub 2018 Jul 30.

Pediatrics, Dalhousie University, Halifax, Nova Scotia, Canada.

We report a previously well paediatric patient with two distinct presentations of invasive group A streptococcus (GAS) infection resulting in significant morbidity. The first episode, following GAS pharyngitis, involved multiorgan dysfunction syndrome. This included cardiorespiratory and acute hepatorenal failure and purpura fulminans that eventually necessitated four-limb amputation. Read More

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http://casereports.bmj.com/lookup/doi/10.1136/bcr-2018-22529
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http://dx.doi.org/10.1136/bcr-2018-225292DOI Listing
July 2018
10 Reads

Structure of ScpC, a virulence protease from , reveals the functional domains and maturation mechanism.

Biochem J 2018 09 11;475(17):2847-2860. Epub 2018 Sep 11.

Department of Biological Sciences, 14 Science Drive 4, National University of Singapore, Singapore 117543

Group A Streptococcus (GAS; ) causes a wide range of infections, including pharyngitis, impetigo, and necrotizing fasciitis, and results in over half a million deaths annually. GAS ScpC (SpyCEP), a 180-kDa surface-exposed, subtilisin-like serine protease, acts as an essential virulence factor that helps evade the innate immune response by cleaving and inactivating C-X-C chemokines. ScpC is thus a key candidate for the development of a vaccine against GAS and other pathogenic streptococcal species. Read More

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http://biochemj.org/lookup/doi/10.1042/BCJ20180145
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http://dx.doi.org/10.1042/BCJ20180145DOI Listing
September 2018
19 Reads
4.400 Impact Factor