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Singapore Med J 2022 Jun 24. Epub 2022 Jun 24.

Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore.

J Cardiovasc Dev Dis 2022 May 25;9(6). Epub 2022 May 25.

Department of Internal Medicine II, Division of Cardiology, Paracelsus Medical University of Salzburg, 5020 Salzburg, Austria.

(1) Background: Myocarditis following group A streptococcal pharyngitis and tonsillitis is a relatively rare medical condition. The aim of this systematic review was to identify specific ECG changes, laboratory parameters and signs, and symptoms associated with this disease. (2) Methods: A systematic literature review was performed in concordance with the current PRISMA guidelines, including the databases PubMed/MEDLINE, Web of Science, CDSR, CENTRAL, CCAs, EBM Reviews, and LILACS. Read More

J Cancer Res Clin Oncol 2022 Jun 22. Epub 2022 Jun 22.

Medical Clinic III for Oncology, Hematology, Immune-Oncology and Rheumatology, University Medical Center Bonn (UKB), Venusberg-Campus 1, 53127, Bonn, Germany.

Infection of lymphocytes with the Epstein-Barr virus (EBV) is a well-documented risk factor for developing lymphoma. The incidence of EBV positivity in lymphoma depends on the subtype and can range from 10% in diffuse large B-cell lymphoma (DLBCL) to 100% in endemic Burkitt lymphoma (BL), (Shannon-Lowe and Rickinson, Front Oncol 9:713, 2019). However, in most cases, EBV infection remains unnoticed until diagnosis of lymphoma is made. Read More

Chin Med J (Engl) 2022 Apr 20;135(8):911-919. Epub 2022 Apr 20.

Department of Rheumatology and Immunology, The First Medical Center, Chinese PLA General Hospital, Beijing 100853, China.

Background: Concerns exist regarding the risk of infections in patients with spondyloarthritis (SpA) treated with biologics. We assessed the risk of infections of biological and targeted drugs in patients with SpA by performing a meta-analysis based on randomized controlled trials (RCTs).

Methods: A systematic literature search was conducted in PubMed, Embase, Web of Science, the Cochrane Library, and China Biology Medicine Disc for RCTs evaluating the risk of infections of biological therapy in patients with SpA from inception through August 9, 2021. Read More

S D Med 2022 May;75(5):212-215

Department of Pediatrics, University of South Dakota Sanford School of Medicine, Sioux Falls, South Dakota.

A previously healthy 8-year-old Native American female presented with right-sided weakness and joint pain for two weeks. Following an initially unremarkable workup including negative brain and spine MRI she was noticed to have chorea and subsequently diagnosed with acute rheumatic fever (ARF). ARF is a group A streptococcus-related disease that most commonly is a sequelae of pharyngitis. Read More

Pan Afr Med J 2022 21;41:230. Epub 2022 Mar 21.

Service d'Anesthésie-Réanimation Chirurgicale, Centre Hospitalier Universitaire Habib Bourguiba Sfax, Sfax, Tunisie.

Introduction: post-operative laryngeal pain (POLP) is frequent and embarrassing. The purpose of this study is to assess the efficacy of endotracheal tube balloon (ETB) inflation with alkalinized lidocaine in the prevention of the POLP.

Methods: we conducted a prospective, single-center, double-blind, randomized study including patients undergoing general anesthesia with tracheal intubation (OTI) with an expected duration of less than 240 min. Read More

Zhongguo Zhong Yao Za Zhi 2022 May;47(10):2819-2824

China-Japan Friendship Hospital Beijing 100029, China.

Jingfang Granules have the effects of inducing sweating to releasing exterior, dispersing wind and dispelling dampness. Modern studies have demonstrated that it has antipyretic and antiviral activities. Therefore, this trial was conducted to evaluate the efficacy and safety of Jingfang Granules in the treatment of common cold(wind-cold syndrome). Read More

J Pediatr 2022 Jun;245:80

University College of Medical Sciences, Delhi, India.

BMC Prim Care 2022 Jun 17;23(1):154. Epub 2022 Jun 17.

Institute of Medical Statistics, and Computational Biology (IMSB), Medical Faculty, University at Cologne, Cologne, Germany.

Background: Benzydamine for oromucosal use is indicated in the relief of pain and irritation of the mouth and throat. It is an indazole derivative, non-steroidal anti-inflammatory drug, with combined local anesthetic and analgesic properties, and antiseptic activity, marketed under the brand name "Tantum Verde". The aim of this study was to explore knowledge and prescriptive/advising attitudes among general practitioners (GPs) and pharmacists (PHs) with regard to the topical treatment of sore throat and other irritative/inflammatory conditions of the oropharynx, with a focus on benzydamine. Read More

J Am Coll Emerg Physicians Open 2022 Jun 11;3(3):e12751. Epub 2022 Jun 11.

University of Alabama at Birmingham Department of Emergency Medicine Birmingham Alabama USA.

EClinicalMedicine 2022 Jun 20;48:101458. Epub 2022 May 20.

Wesfarmers Centre of Vaccines and Telethon Kids Institute, University of Western Australia, PO Box 855, West Perth, Nedlands, WA 6872, Australia.

Background: Contemporary data for the global burden of sore throat and group A (Strep A) pharyngitis are required to understand the frequency of disease and develop value propositions for Strep A vaccines.

Methods: We used Clarivate Analytics' Web of Science platform to search WoS core collection, PubMed, Medline, data citation index, KCI-Korean Journal Database, Russian Science Citation Index, and the SciELO Citation Index for articles published between Jan 1, 2000, and Feb 15, 2021, from any country and in any language. The risk of bias was assessed using the JBI critical appraisal checklist. Read More

Am Fam Physician 2022 Jun;105(6):Online

USA.

Rev Paul Pediatr 2022 10;40:e2021087. Epub 2022 Jun 10.

Universidade Positivo, Curitiba, PR, Brazil.

Objective: To describe clinical, diagnostic and therapeutic characteristics of the periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis (PFAPA) syndrome.

Data Source: Literature review in the PubMed database by using specific descriptors to identify all articles published in the English language in the last three years; 38 articles were found. After performing selection of titles and abstract analysis, 13 out of the 38 articles were fully read. Read More

Pediatrics 2022 Jun 15. Epub 2022 Jun 15.

Division of Urgent Care, Children's Mercy Kansas City, University of Missouri-Kansas City School of Medicine, Kansas City, Missouri.

Background: Urgent care (UC; a convenient site to receive care for ambulatory-sensitive) centers conditions; however, UC clinicians showed the highest rate of inappropriate antibiotic prescriptions among outpatient settings according to national billing data. Antibiotic prescribing practices in pediatric-specific UC centers were not known but assumed to require improvement. The aim of this multisite quality improvement project was to reduce inappropriate antibiotic prescribing practices for 3 target diagnoses in pediatric UC centers by a relative 20% by December 1, 2019. Read More

JAMA 2022 06;327(22):2231-2237

Durham Veterans Affairs Medical Center, Durham, North Carolina.

Importance: Acute infectious conjunctivitis is characterized by ocular redness and discharge, and is a common clinical entity. Evidence-based tools to aid the clinical diagnosis of viral vs bacterial conjunctivitis are lacking and may contribute to overprescribing of topical antibiotics.

Objective: To determine the relative prevalence of viral vs bacterial conjunctivitis in adults and children, and to determine which symptoms or signs are suggestive of a viral vs bacterial etiology. Read More

Acta Med Acad 2022 Apr;51(1):1-13

Scientific Research Unit, Bosnalijek d.d., Bosnia and Herzegovina; Department for Biochemistry and Clinical Analysis, Faculty of Pharmacy, University of Sarajevo, Bosnia and Herzegovina; School of Medicine, University of Mostar, Bosnia and Herzegovina.

Objective: This study aimed to evaluate the efficacy and safety of lysozyme-based oral antiseptic in the therapy of non-infectious sore throat in teachers.

Materials And Methods: A non-interventional, prospective, pilot study was conducted with two examinations. The first was performed as part of a general medical examination. Read More

Eur J Gen Pract 2022 Dec;28(1):142-149

Department of Family Medicine and Siaal Research Center for Family Medicine and Primary Care, The Haim Doron Division of Community Health, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

Background: Acute upper respiratory infections are the most common reason for primary physician visits in the community. This study investigated whether the type of antibiotic used to treat streptococcal tonsillitis can reduce the burden by affecting the number of additional visits.

Objectives: To assess the effect of different antibiotic treatments for tonsillitis on the number of additional primary physician visits and the development of infectious or inflammatory sequels. Read More

Int J Environ Res Public Health 2022 06 6;19(11). Epub 2022 Jun 6.

Department of Pediatrics, Tokyo Women's Medical University Yachiyo Medical Center, 477-96 Owada-Shinden, Yachiyo 276-0046, Chiba, Japan.

The study tested the hypothesis that human mobility may be a potential factor affecting reductions in droplet-transmissible pediatric infectious diseases (PIDs) during the coronavirus disease-2019 (COVID-19) pandemic mitigation period in 2020. An ecological study was conducted using two publicly available datasets: surveillance on infectious diseases collected by the Japanese government and COVID-19 community mobility reports presented by Google. The COVID-19 community mobility reports demonstrated percentage reductions in the movement of people over time in groceries and pharmacies, parks, and transit stations. Read More

PLoS One 2022 9;17(6):e0264298. Epub 2022 Jun 9.

Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America.

The association between COVID-19 symptoms and antibody responses against SARS-CoV-2 is poorly characterized. We analyzed antibody levels in individuals with known SARS-CoV-2 infection to identify potential antibody-symptom associations. Convalescent plasma from 216 SARS-CoV-2 RNA+ individuals with symptomatology information were tested for the presence of IgG to the spike S1 subunit (Euroimmun ELISA), IgG to receptor binding domain (RBD, CoronaCHEK rapid test), and for IgG, IgA, and IgM to nucleocapsid (N, Bio-Rad ELISA). Read More

Nan Fang Yi Ke Da Xue Xue Bao 2022 May;42(5):747-751

Laboratory of Health and Genetic Psychology, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China.

Objective: To explore the correlation of temperament type and mother's emotional state with acute respiratory tract infections in children so as to provide evidence for comprehensive treatment of the infections.

Methods: A total of 200 children aged between 3 and 6 were enrolled in this study from two kindergartens of Guangzhou and Hengyang. The mothers were invited to complete a questionnaire of the children's general information followed by assessment using children's temperament scale and the Depression-Anxiety-Stress Scale. Read More

BMC Infect Dis 2022 Jun 7;22(1):524. Epub 2022 Jun 7.

UK Health Security Agency, London, UK.

Background: The European Gonococcal Antimicrobial Surveillance Programme (Euro-GASP) performs annual sentinel surveillance of Neisseria gonorrhoeae susceptibility to therapeutically relevant antimicrobials across the European Union/European Economic Area (EU/EEA). We present the Euro-GASP results from 2019 (26 countries), linked to patient epidemiological data, and compared with data from previous years.

Methods: Agar dilution and minimum inhibitory concentration (MIC) gradient strip methodologies were used to determine the antimicrobial susceptibility (using EUCAST clinical breakpoints, where available) of 3239 N. Read More

Dtsch Med Wochenschr 2022 Jun 7;147(12):743-744. Epub 2022 Jun 7.

Abteilung Infektiologie, Klinik für Innere Medizin II, Universitätsklinikum Freiburg, Medizinische Fakultät, Albert-Ludwigs-Universität Freiburg, Freiburg, Deutschland.

Infect Drug Resist 2022 31;15:2763-2771. Epub 2022 May 31.

Department of Clinical Infectious Diseases, Aichi Medical University Hospital, Nagakute, Aichi, 480-1195, Japan.

Although is a commensal microorganism of the oral cavity, it may sometimes cause severe systemic infections. We report a case of Lemierre syndrome (LS), which developed after infection, in a 73-year-old Japanese woman who was admitted to the hospital for throat pain, neck swelling, and fever for 3 days. She had a 3-month history of neglected dental caries, gingivitis, and periodontitis. Read More

BMJ Case Rep 2022 Jun 6;15(6). Epub 2022 Jun 6.

Otolaryngology-Head and Neck Surgery (ENT), AIIMS, Raipur, CG, India

Peritonsillar abscess is a common presentation of complicated acute tonsillitis. The temporomandibular joint septic arthritis is an uncommon clinical entity while its complications are further rare. We present a case of a man in his late 30s who presented with a painful swelling in the left preauricular region along with increasing trismus. Read More

Lancet 2022 06 26;399(10341):2113-2128. Epub 2022 May 26.

Inflammatory Bowel Disease Unit, Division of Gastroenterology and Hepatology, University of Calgary, Calgary, AB, Canada.

Background: There is a great unmet need for advanced therapies that provide rapid, robust, and sustained disease control for patients with ulcerative colitis. We assessed the efficacy and safety of upadacitinib, an oral selective Janus kinase 1 inhibitor, as induction and maintenance therapy in patients with moderately to severely active ulcerative colitis.

Methods: This phase 3, multicentre, randomised, double-blind, placebo-controlled clinical programme consisted of two replicate induction studies (U-ACHIEVE induction [UC1] and U-ACCOMPLISH [UC2]) and a single maintenance study (U-ACHIEVE maintenance [UC3]). Read More

Mod Rheumatol Case Rep 2022 May 27. Epub 2022 May 27.

Vasculitis Research Unit and Clinical Unit of Autoinflammatory Diseases, Department of Autoimmune Diseases, Hospital Clinic of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain.

Periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis (PFAPA) syndrome, a polygenic or multifactorial condition, is the most frequent autoinflammatory disease in children. There is increasing evidence that some patients may have a disease onset during adulthood. With regard to PFAPA syndrome treatment, single medium-to-high doses of glucocorticoids during flares constitute the therapy of choice in children and adults, colchicine may be useful in some patients and tonsillectomy has been reported of utility mainly in pediatric patients. Read More

Curr Rheumatol Rev 2022 May 27. Epub 2022 May 27.

Medical Faculty, Peoples\' Friendship University of Russia, Moscow, Russian Federation.

Background: Pulmonary manifestations and lung impairment are rarely associated with the adult Still's disease and are reported in less than 5%.

Case Presentation: The present clinical case describes the adult Still's disease with pulmonary involvement in a 45- year-old male. The main clinical manifestations included continuous fever, failure to respond to antibiotic therapy, skin rashes, musculoskeletal syndrome and pharyngitis. Read More

Immun Inflamm Dis 2022 Jun;10(6):e632

Department of Biostatistics and Cancer Registration, Guangzhou Center for Disease Control and Prevention, Guangzhou, P. R. China.

Background: To analyze the epidemic characteristics of the human rhinovirus (HRV) outbreaks in Guangzhou, China, in 2020.

Methods: Descriptive epidemiological methods were used to analyze the HRV-related outbreaks in Guangzhou, 2020.

Results: Seventeen outbreaks were reported in 2020 during the coronavirus disease 2019 (COVID-19) pandemic in Guangzhou, a total of 465 patients (290 males and 175 females) were enrolled, with a median age of 10. Read More

Medicina (Kaunas) 2022 Apr 25;58(5). Epub 2022 Apr 25.

Department of Otorhinolaryngology, Head and Neck Surgery, University Medical Center Mainz, 55131 Mainz, Germany.

Tonsillar infections are a common reason to see a physician and lead to a reduction in the patients' health-related quality of life (HRQoL). HRQoL may be an important criterion in decision science and should be taken into account when deciding when to perform tonsillectomy, especially for chronic tonsillitis. The aim of this study was to determine the health utility for different states of tonsillar infections. Read More

Medicine (Baltimore) 2022 May 27;101(21):e29469. Epub 2022 May 27.

Department of Emergency and Internal Medicine, Saitama Citizens Medical Center, Saitama, Japan.

Rationale: Since late 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) had rapidly spread worldwide, resulting in a pandemic. Patients with coronavirus disease 2019 (COVID-19) have difficulty in visiting clinics in person during pandemic because they might be encouraged to quarantine at home with supportive care. Peritonsillar abscess rarely coexists with COVID-19; however, patients with SARS-CoV-2 infection could get co-infections or become superinfected with other microorganisms which could cause peritonsillar abscess. Read More