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Jpn J Med (Lond) 2018 ;1(6):269-275

Department of Microbiology and Immunology, Montana State University, Bozeman, MT 59718, USA.

Group A (GAS) causes common pharyngitis and skin infections and occasional severe invasive infections. This review describes the recent progress on the pathogenesis of hypervirulent GAS. CovRS mutations are frequent among invasive GAS isolates and lead to hypervirulence. Read More

Res Social Adm Pharm 2018 Dec 7. Epub 2018 Dec 7.

School of Pharmacy, University of Waterloo, 10 Victoria St S A, Kitchener, N2G 1C5, ON, Canada; Ontario Pharmacy Evidence Network (OPEN), School of Pharmacy, University of Waterloo, 10 Victoria St S A, Kitchener, N2G 1C5, ON, Canada.

Background: Pharmacists have been shown to be beneficial for inclusion in emergency department (ED) services; however, little has been done to assess these benefits with pharmacists having even wider scopes of practice, including limited prescribing authority.

Objectives: The aims of this study were to determine the proportion of ED visits that can potentially be managed by pharmacists, the most prevalent conditions within these cases, and the factors associated with patients presenting with such cases to the ED.

Methods: This was a retrospective quantitative cohort study using administrative databases from 2010 to 2017. Read More

Eur J Pharm Biopharm 2018 Dec 10. Epub 2018 Dec 10.

University of Antwerp, Department of Pharmaceutical, Biomedical and Veterinary Sciences, Laboratory of Pharmaceutical Technology and Biopharmacy, Universiteitsplein 1, B-2610 Wilrijk, Belgium. Electronic address:

Tablets are increasingly explored as dosage form for oral probiotics, especially for applications such as pharyngitis and dental health. In such tablets, the dry form increases the stability and the shelf life of the product. In addition, the probiotic cells are entrapped in the tablet matrix, which protects them against the environmental factors in the human body. Read More

J Pediatr 2018 Dec 6. Epub 2018 Dec 6.

Department of Medicine, Division of Infectious Diseases, Marshfield Clinic Health System, Marshfield, WI.

Objective: To evaluate the epidemiology, clinical features, and antibiotic prescribing patterns for nongroup A streptococci (NGAS) in children.

Study Design: Throat cultures obtained for pharyngitis were assessed at a large community-based health system over 10 years. Epidemiologic and clinical features of children with NGAS were compared with children with group A Streptococcus (GAS) and negative cultures. Read More

Infect Drug Resist 2018 8;11:2199-2205. Epub 2018 Nov 8.

Department of Health Sciences, Medical School, University of Catanzaro "Magna Græcia", Catanzaro, Italy,

Purpose: The overuse, misuse, and underuse of antimicrobial agents often lead to the spread of antibiotic-resistant microorganisms. The aim of our study was to describe the pattern of antibiotic prescriptions for acute respiratory tract infections (RTIs) among the adult population and the factors associated with antibiotic prescribing.

Patients And Methods: The study involved patients who visited a general practitioner with suspected acute RTI. Read More

Saudi J Biol Sci 2018 Nov 9;25(7):1468-1472. Epub 2017 May 9.

Department of Otolaryngology-Head and Neck Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250021, China.

The aim of the present study was to investigate the effect of resveratrol on acute pharyngitis in the mice models induced by xylene and carrageenan treatment. The mice treated with various doses of resveratrol (5, 10, 15, 20 and 30 mg/kg) showed inhibition of edema in a dose dependent manner. The edema formation was reduced by 67% in the mice treated with 20 mg/kg of resveratrol compared to those in the control group. Read More

J Ethnopharmacol 2018 Nov 26;231:275-282. Epub 2018 Nov 26.

Shenzhen Key Laboratory of ENT, Institute of ENT & Longgang ENT Hospital, Shenzhen 518172, China.

Ethnopharmacological Relevance: Yan-Hou-Qing (YHQ), a Chinese medicine formula containing fourteen kinds of materials, has been designed for pharyngitis and cough treatment in Oriental medicine. In the present study, the anti-allergic effects and underlying mechanisms of YHQ in inhibition of airway hyper responsiveness (AHR) was explored in an ovalbumin (OVA)-induced allergic asthma mouse model.

Materials And Methods: BALB/c mice were sensitized by OVA and cholera toxin (CT) and challenged with OVA intranasally to induce allergic asthma mouse model. Read More

Clin Rheumatol 2018 Nov 28. Epub 2018 Nov 28.

Research Center of Systemic Autoinflammatory Diseases and Behçet's Disease and Rheumatology-Ophthalmology Collaborative Uveitis Center, Department of Medical Sciences, Surgery and Neurosciences, University of Siena, Siena, Italy.

Periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome is the most frequent non-hereditary autoinflammatory disorder in childhood: Its onset is usually observed before 5 years, though reports regarding adulthood are increasing. The pathogenesis of the syndrome is not completely understood, but a multifactorial origin, probably based on a polygenic pattern of susceptibility, is the most probable rational pathogenetic hypothesis. Treatment of PFAPA syndrome relies on the administration of low-dose corticosteroids, which promptly abort flares but cannot prevent subsequent disease episodes over time. Read More

Am J Emerg Med 2018 Nov 17. Epub 2018 Nov 17.

Northwell North Shore University Hospital, Department of Emergency Medicine, 300 Community Dr, Manhasset, NY 11030, United States of America. Electronic address:

Objective: We studied the impact four new urgent care centers (UCCs) had on a hospital emergency department (ED) in terms of overall census and proportion of low acuity diagnoses from 2009 to 2016. We hypothesized that low acuity medical problems frequently seen in UCCs would decrease in the ED population. Since Medicaid was not accepted at these UCCs, we also studied the Medicaid vs non-Medicaid discharged populations to see if there were some differences related to access to urgent care. Read More

Infect Drug Resist 2018 31;11:2063-2067. Epub 2018 Oct 31.

Department of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo, Japan,

was the main causative organism for acute epiglottitis in the pre- type b (Hib) vaccine era. However, with current widespread Hib vaccination, the causative organisms may have changed. Here, we report the case of a healthy infant with acute epiglottitis caused by community-acquired methicillin-resistant (MRSA). Read More

J Clin Microbiol 2018 Nov 21. Epub 2018 Nov 21.

Department of Pathology and Laboratory Medicine, Children's Mercy Hospital and Clinics, Kansas City, MO, USA

Group A (GAS) is one of the leading causes of bacterial pharyngitis. Early GAS diagnosis is critical for appropriate antibiotic administration that reduces the risk of GAS sequela and limits spread of the infection. The ARIES Group A Strep (GAS) Assay (Luminex, Austin, TX) is a fully automated PCR assay for direct detection of GAS in throat swab specimens in less than two hours with minimum hands-on time. Read More

Emerg Med Clin North Am 2019 Feb;37(1):95-107

Department of Emergency Medicine, Loma Linda University School of Medicine, 11234 Anderson Street MC A-108, Loma Linda, CA 92354, USA. Electronic address:

Infection of the neck is a relatively common emergency department complaint. If not diagnosed and managed promptly, it may quickly progress to a life-threatening infection. These infections can result in true airway emergencies that may require fiberoptic or surgical airways. Read More

Emerg Med Clin North Am 2019 Feb;37(1):69-80

Department of Emergency Medicine, Northwestern University, 211 East Ontario - Suite 300, Chicago, IL 60611, USA. Electronic address:

This article reviews the presentation, diagnosis, and management of common and "can't miss" infections of the oropharynx, including streptococcal pharyngitis, infectious mononucleosis, peritonsillar abscess, retropharyngeal abscess, and epiglottitis. Read More

Cas Lek Cesk 2018 ;157(3):122-129

Autoinflammatory diseases represent a relatively new and rapidly evolving group of rare disorders associated with mutations of genes encoding proteins with a key regulatory role in inflammatory response. Gradual discovery of mechanisms that link genetic disorder with its biochemical and immunological consequences leading to continuous or episodic inflammatory stimulation has enabled introduction of directed immunotherapies. Periodic fever syndromes belong to the so far best-known entities: familial Mediterranean fever, mevalonate kinase deficiency, cryopyrinopathies and TNF-receptor associated periodic syndrome. Read More

Laryngoscope 2018 Nov 15. Epub 2018 Nov 15.

Department of Otolaryngology and Communication Enhancement, Boston, Massachusetts, U.S.A.

Objective: Pleomorphic adenoma is the most common benign salivary gland neoplasm in children. Recurrence and malignant transformation are concerns necessitating proper treatment. The goal of this research was to discuss the presentation, evaluation, and management of pediatric pleomorphic adenoma of the head and neck. Read More

Mater Sociomed 2018 Mar;30(1):43-48

Faculty of Medical Sciences, University of Kragujevac, Serbia.

Introduction: Quality of life in patients with acute pharyngitis or tonsillitis is significantly lower than in healthy persons, and it should be taken into account when efficacy of new therapeutic options is investigated.

Objective: The aim of this study was to develop and validate a reliable instrument that can measure quality of life in adult outpatients with sore throat caused by acute pharyngitis or acute tonsillitis.

Method: The study was of a cross-sectional type, and assessed reliability and validity of newly developed questionnaire for measurement of quality of life in adult outpatients with sore throat (STQoL) caused by acute pharyngitis or acute tonsillitis. Read More

Can Fam Physician 2018 Nov;64(11):832-840

Professor of Evidence-Based Medicine in the Department of Family Medicine, at the University of Alberta in Edmonton.

Objective: To identify the most commonly presenting conditions in primary care globally, and to compare common reasons for visits (RFVs) as reported by clinicians and patients, as well as among countries of different economic classifications.

Data Sources: Twelve scientific databases were searched up to January 2016, and a dual independent review was performed to select primary care studies.

Study Selection: Studies were included if they contained 20 000 visits or more (or equivalent volume by patient-clinician interactions) and listed 10 or more RFVs. Read More

Fam Pract 2018 Nov 12. Epub 2018 Nov 12.

Département de médecine générale, UFR des sciences de la santé Simone Veil, Université Versailles-Saint-Quentin-en-Yvelines, Montigny le Bretonneux, France.

Background: The safety of non-steroids anti-inflammatory drugs (NSAIDs) in the context of pharyngitis is doubtful with contradictory results in the literature.

Objective: To evaluate the risk of peritonsillar abscess (PTA) associated to NSAIDs consumption during a pharyngitis episode observed in primary care.

Method: A retrospective cohort study using Observatory of General Medicine Datalink from 1995 to 2010. Read More

Mediterr J Hematol Infect Dis 2018 1;10(1):e2018067. Epub 2018 Nov 1.

Institute of Pediatrics, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.

Systemic autoinflammatory disorders (SAIDs) are inherited defects of innate immunity characterized by recurrent sterile inflammatory attacks involving skin, joints, serosal membranes, gastrointestinal tube, and other tissues, which recur with variable rhythmicity and display reactive amyloidosis as a potential long-term complication. Dysregulated inflammasome activity leading to overproduction of many proinflammatory cytokines, such as interleukin-1 (IL-1), and delayed shutdown of inflammation are considered crucial pathogenic keys in the vast majority of SAIDs. Progress of cellular biology has partially clarified the mechanisms behind monogenic SAIDs, such as familial Mediterranean fever, tumor necrosis factor receptor-associated periodic syndrome, cryopyrin-associated periodic syndrome, mevalonate kinase deficiency, hereditary pyogenic diseases, idiopathic granulomatous diseases and defects of the ubiquitin-proteasome pathway. Read More

Pharm Pract (Granada) 2018 Jul-Sep;16(3):1194. Epub 2018 Aug 12.

Faculty of Pharmacy & Faculty of Public Health, Lebanese University, Hadat (Lebanon).

Objectives: to assess the knowledge of both parents and community pharmacists regarding antibiotics use and resistance in pediatrics in Lebanon.

Methods: A cross-sectional study was conducted between June and August 2017 in community pharmacies. A pre-established questionnaire targeting knowledge of parents and pharmacists regarding antibiotics use/misuse was carried out. Read More

Hong Kong Med J 2018 Nov 9. Epub 2018 Nov 9.

Department of Paediatrics, Alberta Children's Hospital, The University of Calgary, Calgary, Alberta, Canada.

Group A β-haemolytic or is a gram-positive coccus that tends to grow in chains. is the cause of many important human diseases, ranging from pharyngitis and mild superficial skin infections to life-threatening systemic diseases. Infections typically begin in the throat or skin. Read More

Oman Med J 2018 Nov;33(6):523-526

Radiology Department, Khoula Hospital, Muscat, Oman.

Lemierre's syndrome is a rare, life-threatening condition, which may be fatal if not properly treated. This disease refers to thrombophlebitis of the internal jugular vein, which is the result of bacterial sore throat infection (usually in the form of pharyngitis) that extends into the parapharyngeal space. However, it can result from other infective foci in the ear, nose, parotid glands, and paranasal sinuses. Read More

Pediatr Infect Dis J 2018 Dec;37(12):1248-1254

Medical and Clinical Pharmacy Policy, Anthem, Inc, Chicago, Illinois.

Background: Antibiotics are commonly prescribed for children with acute respiratory infections (ARIs). This study describes the distribution of ARI diagnoses and specifically quantifies antibiotic dispensing for bronchitis and upper respiratory infection (URI) by treatment setting and specialty.

Methods: This retrospective, observational cross-sectional study used data from the HealthCore Integrated Research Environment containing claims from 14 commercial health plans for 2012 to 2014. Read More

Eur J Rheumatol 2018 Nov 6:1-7. Epub 2018 Nov 6.

Dartmouth-Hitchcock Medical Center, Geisel School of Medicine at Dartmouth, New Hampshire, USA.

Objective: The Periodic fever syndromes (PFS) are a group of disorders of the innate immune system. We investigated patients diagnosed with PFS at the Dartmouth Hitchcock Pediatric Rheumatology Clinic.

Methods: Case acquisition was performed by reviewing ICD 9/10 coded records for familial Mediterranean fever (ICD 9 277. Read More

Korean J Neurotrauma 2018 Oct 31;14(2):155-158. Epub 2018 Oct 31.

Department of Neurosurgery, Gyeongsang National University Hospital, Gyeongsang National University School of Medicine, Jinju, Korea.

Deep neck infections (DNIs) are mainly caused by dental caries, tonsillitis, and pharyngitis; however, DNIs can also occur after head and neck trauma. A 79-year-old male patient underwent a craniectomy due to an acute subdural hematoma. The patient was unconscious and continued to have a fever, but no clear cause was found. Read More

Br J Gen Pract 2018 Nov 5. Epub 2018 Nov 5.

Institute of Applied Health Research, University of Birmingham, Birmingham, UK.

Background: Neither the incidence of indications for childhood tonsillectomy nor the proportion of tonsillectomies that are evidence-based is known.

Aim: To determine the incidence of indications for tonsillectomy in UK children, and the proportion of tonsillectomies meeting evidence-based criteria.

Design And Setting: A retrospective cohort study of electronic medical records of children aged 0-15 years registered with 739 UK general practices contributing to a research database. Read More

Dig Dis Sci 2018 Nov 2. Epub 2018 Nov 2.

Takeda Development Center Americas, Inc, Deerfield, IL, USA.

Background: In gastroesophageal reflux disease (GERD), the frequency of heartburn symptoms and erosive esophagitis (EE) increases with age in children and adolescents. Proton pump inhibitor, dexlansoprazole, is approved for healing EE of all grades, maintenance of healed EE, relief of heartburn, and treatment of symptomatic non-erosive GERD in patients ≥ 12 years.

Aim: To assess safety and efficacy of dexlansoprazole dual delayed-release capsule in healing of EE and maintenance of healed EE in adolescents. Read More

Circulation 2018 Oct;138(18):1920-1922

Kupat Holim Meuhedet, Jerusalem District, Israel.

Acta Parasitol 2018 Dec;63(4):839-844

Instituto de Patología Animal, Facultad de Ciencias Veterinarias, Universidad Austral de Chile, Isla Teja s/n, 5090000, Valdivia, Chile.

The tissues and parasites collected from Peruvian fur seals (Arctocephalus australis) and South American sea lions (Otaria byronia) found dead at Punta San Juan, Peru were examined. The respiratory mite, Orthohalarachne attenuata infected 3 out of 32 examined fur seals and 3 out of 8 examined sea lions, however caused moderate to severe lymphohistiocytic pharyngitis only in fur seals. Hookworms, Uncinaria sp, infected 6 of the 32 examined fur seals causing variable degrees of hemorrhagic and eosinophilic enteritis. Read More

Ann Med Surg (Lond) 2018 Nov 10;35:189-191. Epub 2018 Oct 10.

Clinical Pathology Department, St. Joseph Hospital, 2900 N Lake Shore Dr, Chicago, IL, 60657, USA.

Introduction: Epstein Barr virus (EBV) is a human herpes virus 4, transmitted through intimate contact between susceptible persons and asymptomatic EBV shedders. It usually presents with fever, pharyngitis and lymphadenopathy. Majority of individuals with primary EBV infection recover uneventfully. Read More

Case Rep Otolaryngol 2018 27;2018:7307290. Epub 2018 Sep 27.

Department of Otorhinolaryngology, Juntendo University Faculty of Medicine, Tokyo, Japan.

Deep neck abscess is a life-threatening infection that causes laryngeal edema and upper airway occlusion. The predominant bacterial species involved in this disorder is group A streptococcus. Group G streptococcus (GGS) constitutes the normal commensal flora of the human upper airway. Read More

J Pediatr 2018 Oct 22. Epub 2018 Oct 22.

Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Israel; Pediatric Rheumatology Unit, Schneider Children's Medical Center of Israel, Petach Tikva, Israel.

Objectives: To describe a cohort of pediatric patients diagnosed with periodic fever aphthous stomatitis, pharyngitis and adenitis (PFAPA) and familial Mediterranean fever (FMF) and compare them with children diagnosed solely with PFAPA (sPFAPA).

Study Design: Clinical, laboratory, and genetic data of all pediatric patients diagnosed with sPFAPA or PFAPA/FMF were retrospectively collected from 2 primary Israeli medical referral centers and compared.

Results: Of 270 patients with PFAPA, more than one-half were of Mediterranean ancestry. Read More

J Community Hosp Intern Med Perspect 2018 15;8(5):317-320. Epub 2018 Oct 15.

Internal Medicine Department, McLaren-Flint/Michigan State University, Flint, MI, USA.

A 47-year-old female with a history of chronic alcoholism presented with nausea, vomiting and mild epigastric tenderness. She reported subjective fever, abdominal fullness and loose, watery stools and had stable vitals on arrival. Examination was positive for mild epigastric tenderness with hepatic enlargement. Read More

Br J Pain 2018 Nov 25;12(4):208-216. Epub 2018 Jan 25.

Reckitt Benckiser, Parsippany, NJ, USA.

Background: The double stopwatch (DSW) method for determining the onset of analgesic activity has been implemented extensively by investigators studying orally administered drugs.

Objective: The aim of this randomised, placebo-controlled trial was to use the DSW method to determine the time to onset of analgesia of a single dose of a topically administered non-steroidal anti-inflammatory drug, flurbiprofen 8.75 mg lozenge. Read More

Natl Med J India 2018 Jan-Feb;31(1):8-10

Department of Paediatrics, Kanchi Kamakoti CHILDS Trust Hospital and The CHILDS Trust, Medical Research Foundation, 12-A, Nageswara Road, Nungambakkam, Chennai 600034, Tamil Nadu, India.

Background.: It is difficult to make a diagnosis of group A beta-haemolytic streptococci (GABHS) pharyngitis solely on clinical findings. The McIssac scoring system has been recommended as a reliable clinical tool for diagnosis. Read More

J Emerg Med 2018 Dec 17;55(6):841-844. Epub 2018 Oct 17.

University of California San Diego, San Diego, California.

Background: In the winter months, one often sees a large increase in the volume of patients presenting to emergency departments with acute pharyngitis. While most cases of acute pharyngitis are benign, a rare minority can be life threatening.

Case Report: We report a case of epiglottis with a concomitant peritonsillar abscess (PTA) in an adult who presented to the emergency department with a sore throat. Read More

Med Clin North Am 2018 Nov 20;102(6):1109-1120. Epub 2018 Sep 20.

Otolaryngology-Head and Neck Surgery, University of California, San Francisco, 2233 Post Street, 3rd floor, San Francisco, CA 94115, USA.

Infections of the head and neck are common and appropriately managed by primary care providers in most cases. However, some infections are associated with significant morbidity and require urgent recognition and management by specialty services. These include deep neck space infections originating in the oral cavity, pharynx, and salivary glands, as well as complicated otologic and sinonasal infection. Read More

Int J Clin Pract 2018 Dec 17;72(12):e13272. Epub 2018 Oct 17.

Pharmalog Institut für klinische Forschung GmbH, Munich, Germany.

Objective: The aim of this multi-centre, randomised, double-blind, placebo-controlled trial was to compare the efficacy and safety of the fixed combination of 0.5 mg tyrothricin, 1.0 mg benzalkonium chloride, and 1. Read More

Chin J Nat Med 2018 Oct;16(10):721-731

Tianjin State Key Laboratory of Modern Chinese Medicine and School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China. Electronic address:

The matured, ripen, and dried seeds of Scaphium affine (Mast.) Pierre, known as Pangdahai (PDH) in Chinese and recorded as Sterculia lychnophora Hance (scientific synonym) in the 2015 edition of the Chinese Pharmacopeia, have been widely used in traditional Chinese medicine, Japanese folk medicine, Vietnamese traditional medicine, traditional Thai medicine and Indian traditional medicine. The decoctions of the seeds are used as a remedy for pharyngitis, laryngitis, constipation, cough, menorrhagia, and pain management. Read More

J Infect Chemother 2018 Dec 11;24(12):969-974. Epub 2018 Oct 11.

Disease Control and Prevention Center, National Center for Global Health and Medicine, 1-21-1 Toyama, Shinjuku-ku, Tokyo, 162-8655, Japan.

Purpose: Recent data suggest an association between Fusobacterium necrophorum infection and pharyngotonsillitis among adolescents and adults. However, existing reports are only from North America and Europe. We aimed to identify and compare the prevalence of F. Read More

Rev Med Suisse 2018 Oct;14(622):1781-1784

Centre national des méningocoques, HUG, 1211 Genève 14.

In the last decade, the epidemiology of meningococcal infections in Switzerland and Europe has changed. The prevalence of Y and W serogroups augmented, with more atypical clinical manifestations such as pharyngitis, pneumonia and arthritis. A hypervirulent clonal serogroup W strain of Neisseria meningitidis has emerged in Europe and Switzerland, with a noticeable potential for epidemics as evidenced by its clonality. Read More

Am J Emerg Med 2018 Oct 1. Epub 2018 Oct 1.

Department of Emergency Medicine, Michigan State University College of Human Medicine, Grand Rapids, MI, United States of America; Spectrum Health Hospitals, Grand Rapids, MI, United States of America. Electronic address:

Am J Chin Med 2018 Oct 4:1-32. Epub 2018 Oct 4.

1 Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, P. R. China.

The stems and roots of Marsdenia tenacissima (Roxb.) Wight et Arn., a traditional Chinese medicine and Dai herbal medicine, have been widely used for the treatment of asthma, trachitis, tonsillitis, pharyngitis, cystitis, pneumonia and drug or food poisoning. Read More

Anesth Essays Res 2018 Jul-Sep;12(3):625-629

Department of Anaesthesiology, Sardar Patel Medical College, Bikaner, Rajasthan, India.

Context: Postoperative sore throat (POST) occurs in 21%-65% of patients. Nebulization of ketamine reduces POST.

Aims: The aim of this study is to see the effectiveness of nebulized ketamine in different doses to reduce POST and observe adverse effects, if any. Read More

Postgrad Med J 2018 Oct 3. Epub 2018 Oct 3.

Department of Internal Medicine, University Hospital of Heraklion, Heraklion, Greece.

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Aug;32(16):1275-1276

Cervical pharyngeal syndrome is characterized by the symptom such as sore throat, foreign body sensation or swallowing discomfort which caused by the pathological changes of cervical intervertebral disc and intervertebral structure nonspecific injury. Because of the lack of obvious specificity, it is easy to misdiagnose. Here, we reported a case of cervical pharyngeal syndrome. Read More

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Aug;32(15):1192-1193

The clinical data of large cell neuroendcrine carcinoma were analyzed retrospectively．The patient was a middle-age male,complained of throat pain for 10 years, it was misdiagnosed as chronic pharyngitis. The patient received tracheotomy, vertical laryngeal resection and left cervical lymph node dissection. Half month after surgery, the patient was transferred to the oncology department and remains under follow-up. Read More

BMJ Case Rep 2018 Oct 2;2018. Epub 2018 Oct 2.

Internal Medicine, Cooper University Hospital, Camden, New Jersey, USA.

The use of biologic drugs has expanded since its introduction in the late 1990s. With growing medical use and newer biologic drugs in development, opportunistic infections like remain important adverse effects. It carries major public health concerns, yet evidence-based clinical guidelines for more routine interval screening in patients taking immunosuppressants and exposed to tuberculosis (TB) are lacking. Read More

Int J Pediatr Otorhinolaryngol 2018 Nov 5;114:143-146. Epub 2018 Sep 5.

Michigan Medicine, Department of Otolaryngology, Head & Neck Surgery, Ann Arbor, MI, United States.

Objective: To determine the incidence of intratonsillar abscess (ITA) patients within the population of patients diagnosed with peritonsillar abscess (PTA) and to further characterize the differences in symptomatology and successful treatment strategies between the two groups.

Methods: This study is a retrospective chart review of patients diagnosed with PTA or ITA at our institution from 2000 to 2017. Descriptive and inferential statistics are reported, including univariate and multivariate analyses. Read More

Neuroophthalmology 2018 Oct 11;42(5):306-308. Epub 2018 Jan 11.

Blanton Eye Institute, Department of Ophthalmology, Houston Methodist Hospital, Houston, Texas, USA.

A 6-year-old girl with acute pharyngitis presented with complaints of hypernasal speech and double vision. Examination revealed a bilateral abduction deficit associated with soft palate palsy causing rhinolalia aperta. Cerebrospinal fluid analysis showed albuminocytologic dissociation. Read More