6,114,843 results match your criteria Pharmacology & Toxicology[Journal]

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Ethanol-induced conditioned place preference and aversion differentially alter plasticity in the bed nucleus of stria terminalis.

Neuropsychopharmacology 2019 Feb 22. Epub 2019 Feb 22.

Department of Pharmacology, Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Thurston Bowles Building 104 Manning Drive, Chapel Hill, NC, 27599, USA.

Contextual cues associated with drugs of abuse, such as ethanol, can trigger craving and drug-seeking behavior. Pavlovian procedures, such as place conditioning, have been widely used to study the rewarding/aversive properties of drugs and the association between environmental cues and drug seeking. Previous research has shown that ethanol as an unconditioned stimulus can induce a strong conditioned place preference (CPP) or aversion (CPA) in rodents. Read More

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http://dx.doi.org/10.1038/s41386-019-0349-0DOI Listing
February 2019

Analytical Validation of Variants to Aid in Genotype-Guided Therapy for Oncology.

J Mol Diagn 2019 Feb 19. Epub 2019 Feb 19.

Department of Medicine, Division of Clinical Pharmacology.

The Clinical Laboratory Improvement Amendments (CLIA) of 1988 requires that pharmacogenetic genotyping methods need to be established according to technical standards and laboratory practice guidelines before testing can be offered to patients. Testing methods for variants in ABCB1, CBR3, COMT, CYP3A7, C8ORF34, FCGR2A, FCGR3A, HAS3, NT5C2, NUDT15, SBF2, SEMA3C, SLC16A5, SLC28A3, SOD2, TLR4, and TPMT were validated in a CLIA-accredited laboratory. As no known reference materials were available, DNA samples that were from Coriell Cell Repositories (Camden, NJ) were used for the analytical validation studies. Read More

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http://dx.doi.org/10.1016/j.jmoldx.2019.01.009DOI Listing
February 2019

Novel trajectories for identifying asthma phenotypes: a longitudinal study in Korean asthma cohort, COREA.

J Allergy Clin Immunol Pract 2019 Feb 19. Epub 2019 Feb 19.

Department of Allergy and Clinical Immunology, University of Ulsan College of Medicine, Seoul, Korea. Electronic address:

Background: Unbiased cluster analysis has identified several asthma phenotypes. However, these phenotypes did not consistently predict disease prognosis and reflect temporal variability of airway inflammation.

Objective: We aimed to identify longitudinal trajectories in terms of pulmonary function parameters and investigated whether the trajectories are associated with prognosis. Read More

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http://dx.doi.org/10.1016/j.jaip.2019.02.011DOI Listing
February 2019

The acyl-glucuronide metabolite of ibuprofen has analgesic and anti-inflammatory effects via the TRPA1 channel.

Pharmacol Res 2019 Feb 19. Epub 2019 Feb 19.

Department of Health Sciences, Section of Clinical Pharmacology and Oncology, University of Florence, Florence, Italy. Electronic address:

Ibuprofen is a widely used non-steroidal anti-inflammatory drug (NSAID) that exerts analgesic and anti-inflammatory actions. The transient receptor potential ankyrin 1 (TRPA1) channel, expressed primarily in nociceptors, mediates the action of proalgesic and inflammatory agents. Ibuprofen metabolism yields the reactive compound, ibuprofen-acyl glucuronide, which, like other TRPA1 ligands, covalently interacts with macromolecules. Read More

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http://dx.doi.org/10.1016/j.phrs.2019.02.019DOI Listing
February 2019

Identification of a quadruple mutation that confers tenofovir resistance in chronic hepatitis B patients.

J Hepatol 2019 Feb 19. Epub 2019 Feb 19.

Department of Pharmacology and Center for Cancer Research and Diagnostic Medicine, IBST, School of Medicine, Konkuk University, Seoul, Korea; KU Open Innovation Center, Konkuk University, Seoul, Korea; Research Institute of Medical Sciences, Konkuk University, Seoul, Korea. Electronic address:

Background & Aims: Tenofovir disoproxil fumarate (TDF) is one the most potent nucleot(s)ide analogues for treating chronic hepatitis B virus (HBV) infection. Phenotypic resistance caused by genotypic resistance to TDF has not been reported. This study aimed to characterize HBV mutations that confer tenofovir resistance. Read More

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http://dx.doi.org/10.1016/j.jhep.2019.02.006DOI Listing
February 2019

Subcommissural organ-Reissner's fiber complex plasticity in tow animal models of copper intoxication and modulatory effect of curcumin: Involvement of serotonin.

J Chem Neuroanat 2019 Feb 19. Epub 2019 Feb 19.

Cadi Ayyad University, Faculty of sciences Semlalia, Neurosciences, Pharmacology and Environment Unit, Marrakesh, Morocco. Electronic address:

Metal neurotoxicity is a universal health preoccupation. Previous data revealed an obvious neurochemical impairment induced by metal elements as copper. This investigation was conducted to study the subcommissural organ (SCO) response to acute and subchronic Cu exposure as well as its serotoninergic innervation in Wistar rats, and the probable protective potential of curcumin in these toxicological circumstances. Read More

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http://dx.doi.org/10.1016/j.jchemneu.2019.02.004DOI Listing
February 2019

Dihydrotestosterone activates AP-1 in LNCaP prostate cancer cells.

Int J Biochem Cell Biol 2019 Feb 19. Epub 2019 Feb 19.

Department of Medical Biochemistry and Molecular Biology, D-66421 Homburg, Germany.

A cross-talk between androgen/androgen receptor signaling and the AP-1 transcription factor has been proposed. In this study, we asked whether activation of AP-1 modifies androgen-responsive gene transcription, and whether androgens effect AP-1-regulated gene transcription. We show that activation of AP-1 via expression of a constitutively active mutant of mitogen-activated/extracellular signal responsive kinase kinase (MEK) kinase-1 did not increase the activity of the androgen-responsive probasin promoter. Read More

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http://dx.doi.org/10.1016/j.biocel.2019.02.005DOI Listing
February 2019

Oral sazetidine-A, a selective α4β2* nicotinic receptor desensitizing agent, reduces nicotine self-administration in rats.

Pharmacol Biochem Behav 2019 Feb 19. Epub 2019 Feb 19.

Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, USA. Electronic address:

Sazetidine-A selectively desensitizes α4β2 nicotinic receptors and also has partial agonist effects. We have shown that subcutaneous acute and repeated injections as well as chronic infusions of sazetidine-A significantly reduce intravenous (IV) nicotine self-administration in rats. To further investigate the promise of sazetidine-A as a smoking cessation aid, it is important to determine sazetidine-A effects with oral administration and the time-effect function for its action on nicotine self-administration. Read More

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http://dx.doi.org/10.1016/j.pbb.2019.02.007DOI Listing
February 2019

Deciphering the virulence of Mycobacterium avium subsp. paratuberculosis isolates in animal macrophages using mathematical models.

J Theor Biol 2019 Feb 19. Epub 2019 Feb 19.

Animal Health Department, NEIKER-Basque Institute for Agricultural Research and Development, Derio, 48160 Bizkaia, Spain.

Understanding why pathogenic Mycobacterium avium subsp. paratuberculosis (Map) isolates cause disparate disease outcomes with differing magnitudes of severity is important in designing and implementing new control strategies. We applied a suite of mathematical models: i) general linear, ii) and neurofuzzy logic, to explain how the host of origin of several Map isolates, Map genotype, host, macrophage-based in vitro model and time post-infection contributed to the infection. Read More

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http://dx.doi.org/10.1016/j.jtbi.2019.01.040DOI Listing
February 2019

GABAR isoform and subunit structural motifs determine synaptic and extrasynaptic receptor localisation.

Neuropharmacology 2019 Feb 19. Epub 2019 Feb 19.

Department of Neuroscience, Physiology and Pharmacology, University College London, Gower Street, London, WC1E 6BT, UK. Electronic address:

GABA receptors (GABARs) are the principal inhibitory neurotransmitter receptors in the central nervous system. They control neuronal excitability by synaptic and tonic forms of inhibition mostly mediated by different receptor subtypes located in specific cell membrane subdomains. A consensus suggests that α1-3βγ comprise synaptic GABARs, whilst extrasynaptic α4βδ, α5βγ and αβ isoforms largely underlie tonic inhibition. Read More

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http://dx.doi.org/10.1016/j.neuropharm.2019.02.022DOI Listing
February 2019

Baicalin exerts antidepressant effects through Akt/FOXG1 pathway promoting neuronal differentiation and survival.

Life Sci 2019 Feb 19. Epub 2019 Feb 19.

Qinba Traditional Chinese Medicine Resources Research and Development Center, AnKang University, AnKang 725000, PR China; Department of Pharmacology of Chinese Materia Medica, China Pharmaceutical University, Nanjing, 639, Longmian Road, Nanjing 211198, China. Electronic address:

Background And Aims: Impaired neurogenesis in hippocampus may contribute to a variety of neurological diseases, such as Alzheimer's disease and depression. Baicalin (BA), which is mainly isolated from the root Scutellaria baicalensis Georgi (traditional Chinese herb), which was reported to facilitate neurogenesis, but how to play the role and the underlying molecular mechanisms are still unknown.

Main Methods: In this study, we adopted the chronic unpredictable mild stress (CUMS)-induced mouse model of depression, and then explore antidepressant-like effects and possible molecular mechanisms. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.02.033DOI Listing
February 2019

Folate receptor-beta expression as a diagnostic target in human & rodent nonalcoholic steatohepatitis.

Toxicol Appl Pharmacol 2019 Feb 19. Epub 2019 Feb 19.

University of Arizona, Department of Pharmacology and Toxicology, Tucson, AZ, USA. Electronic address:

Introduction: Nonalcoholic steatohepatitis (NASH) afflicts 20-36% of individuals with nonalcoholic fatty liver disease (NAFLD). A lipotoxic hepatic environment, altered innate immune signaling and inflammation are defining features of progression to NASH. Activated resident liver macrophages express folate receptor beta (FR-β) which may be an indicator of progression from steatosis to NASH. Read More

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http://dx.doi.org/10.1016/j.taap.2019.02.009DOI Listing
February 2019

Trainee Contribution Is Not Associated With Citation Frequency: A Retrospective Study.

J Oral Maxillofac Surg 2019 Jan 28. Epub 2019 Jan 28.

Assistant Professor, Department of Oral and Maxillofacial Surgery and Pharmacology, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA.

Purpose: Publication citation frequency is a measure of scientific influence. The purpose of this study was to measure the association between trainee involvement in publications and citation frequency.

Materials And Methods: A retrospective cohort study of the Journal of Oral and Maxillofacial Surgery from January to December 2010 was conducted. Read More

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http://dx.doi.org/10.1016/j.joms.2019.01.022DOI Listing
January 2019

Genetic strain and sex differences in a hyperoxia-induced mouse model of varying severity of bronchopulmonary dysplasia.

Am J Pathol 2019 Feb 19. Epub 2019 Feb 19.

Department of Pediatrics, Drexel University College of Medicine, Philadelphia, PA; St. Christopher's Hospital for Children, Philadelphia, PA. Electronic address:

Bronchopulmonary dysplasia (BPD) is a disease prevalent in preterm babies with a need for supplemental oxygen resulting in impaired lung development and dysregulated vascularization. Epidemiological studies have shown that males are more prone to BPD and have a delayed recovery compared to females for reasons unknown. Here, we tried to recapitulate mild, moderate, and severe BPD, using two different strains of mice: CD1 (outbred) and C57BL/6 (inbred), in males and females. Read More

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http://dx.doi.org/10.1016/j.ajpath.2019.01.014DOI Listing
February 2019

Hepatic metabolic adaptation in a murine model of glutathione deficiency.

Chem Biol Interact 2019 Feb 19. Epub 2019 Feb 19.

Department of Environmental Health Sciences, Yale School of Public Health, New Haven, CT, 06521, USA. Electronic address:

Glutathione (GSH), the most abundant cellular non-protein thiol, plays a pivotal role in hepatic defense mechanisms against oxidative damage. Despite a strong association between disrupted GSH homeostasis and liver diseases of various etiologies, it was shown that GSH-deficient glutamate-cysteine ligase modifier subunit (Gclm)-null mice are protected against fatty liver development induced by a variety of dietary and environmental insults. The biochemical mechanisms underpinning this protective phenotype have not been clearly defined. Read More

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http://dx.doi.org/10.1016/j.cbi.2019.02.015DOI Listing
February 2019

Effect of chrysin on the formation of N-acetyl-p-benzoquinoneimine, a toxic metabolite of paracetamol in rats and isolated rat hepatocytes.

Chem Biol Interact 2019 Feb 19. Epub 2019 Feb 19.

Department of Pharmacology, KVSR Siddhartha College of Pharmaceutical Sciences, Vijayawada, Andhra Pradesh, India. Electronic address:

Paracetamol (N-acetyl-para amino phenol) is the most commonly used analgesic and antipyretic around the world. Its causes hepatotoxicity and nephrotoxicity at overdose or even at therapeutic doses. It is primarily metabolized by glucuronidation and sulfate conjugation. Read More

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http://dx.doi.org/10.1016/j.cbi.2019.02.014DOI Listing
February 2019

Discovery of a First-In-Class Covalent Allosteric Inhibitor of SUMO E1 Activating Enzyme.

Cell Chem Biol 2019 Feb;26(2):153-155

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

SUMOylation is a post-translational modification with important roles in normal physiology and whose dysregulation is associated with human diseases. In this issue of Cell Chemical Biology, Li et al. (2019) describe a covalent, allosteric inhibitor of the SUMO E1 enzyme and demonstrate its anti-tumor activity in preclinical models of colorectal cancer. Read More

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http://dx.doi.org/10.1016/j.chembiol.2019.02.006DOI Listing
February 2019

CCR5 Is a Therapeutic Target for Recovery after Stroke and Traumatic Brain Injury.

Cell 2019 Feb;176(5):1143-1157.e13

Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA. Electronic address:

We tested a newly described molecular memory system, CCR5 signaling, for its role in recovery after stroke and traumatic brain injury (TBI). CCR5 is uniquely expressed in cortical neurons after stroke. Post-stroke neuronal knockdown of CCR5 in pre-motor cortex leads to early recovery of motor control. Read More

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http://dx.doi.org/10.1016/j.cell.2019.01.044DOI Listing
February 2019

Acute Corticosterone Treatment Elicits Antidepressant-like Actions on the Hippocampal 5-HT and the Immobility Phenotype.

Brain Res 2019 Feb 19. Epub 2019 Feb 19.

Department of Clinical Pharmacology, School of Pharmacy, China Medical University, Shenyang, 110122, China. Electronic address:

Corticosterone (CORT) has long been shown to modulate 5-HT system, and to alter hippocampal functions in various physiological and pathological conditions. However, CORT-elicited changes in the hippocampal 5-HT transmission and the immobility phenotype had not been fully addressed. The current study sought to explore effects of acute CORT subcutaneously injected at 10, 20, 40 mg/kg on the extracellular 5-HT in the hippocampus and the immobility time in male CD-1 mice. Read More

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http://dx.doi.org/10.1016/j.brainres.2019.02.022DOI Listing
February 2019

Antibiotic treatment-induced dysbiosis differently affects BDNF and TrkB expression in the brain and in the gut of juvenile mice.

PLoS One 2019 22;14(2):e0212856. Epub 2019 Feb 22.

Department of Medicine and Surgery, University of Insubria, Varese, Italy.

Antibiotic use during adolescence may result in dysbiosis-induced neuronal vulnerability both in the enteric nervous system (ENS) and central nervous system (CNS) contributing to the onset of chronic gastrointestinal disorders, such as irritable bowel syndrome (IBS), showing significant psychiatric comorbidity. Intestinal microbiota alterations during adolescence influence the expression of molecular factors involved in neuronal development in both the ENS and CNS. In this study, we have evaluated the expression of brain-derived neurotrophic factor (BDNF) and its high-affinity receptor tropomyosin-related kinase B (TrkB) in juvenile mice ENS and CNS, after a 2-week antibiotic (ABX) treatment. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212856PLOS
February 2019

PCR with electrospray ionization-mass spectrometry on bronchoalveolar lavage for detection of invasive mold infections in hematological patients.

PLoS One 2019 22;14(2):e0212812. Epub 2019 Feb 22.

Department of Infectious Diseases, Karolinska University Hospital, Huddinge, Sweden.

Invasive mold infections are life-threatening complications in patients with hematological malignancies. Conventional microbiological methods for diagnosing invasive pulmonary mold infections have low sensitivity, and molecular methods are being developed. Detection of molds using PCR with a narrow spectrum has been reported, but data with broad-spectrum PCR are lacking. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212812PLOS
February 2019

Antibiotic use practice and predictors of hospital outcome among patients with systemic bacterial infection: Identifying targets for antibiotic and health care resource stewardship.

PLoS One 2019 22;14(2):e0212661. Epub 2019 Feb 22.

Department of Pharmacology and Clinical Pharmacy, School of Pharmacy, College of Health Science, Addis Ababa University, Addis Ababa, Ethiopia.

Background: Malpractice and excess use of antimicrobials have been associated with multiple costs, including the development of resistant bacteria, which has become a threat to the human health. The aim of this study, therefore, was to assess the antibiotic use practice and to identify predictors of hospital outcome to uncover targets for stewardship.

Methods: An Institution-based prospective observational study was performed from 9 April to 7 July 2014 in the internal medicine wards of Tikur Anbessa Specialized Hospital. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212661PLOS
February 2019

Low adherence to Option B+ antiretroviral therapy among pregnant women and lactating mothers in eastern Tanzania.

PLoS One 2019 22;14(2):e0212587. Epub 2019 Feb 22.

School of Public Health, Catholic University of Health and Allied Sciences, Mwanza, Tanzania.

Background: Adherence to option B+ antiretroviral treatment (ART) is vital to a successful implementation of Prevention of Mother to Child Transmission (PMTCT) program. Further studies show that optimal viral suppression is also crucial for a successful PMTCT program, however barriers to adherence exist and differ among populations and particularly within few years of its adoption in Tanzania. This study therefore aimed at investigating the level and predictors of adherence to ART option B+ among pregnant and lactating women in rural and urban settings of eastern Tanzania. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212587PLOS
February 2019

β-Arrestin-2-ERK1/2 cPLAα axis mediates TLR4 signaling to influence eicosanoid induction in ischemic brain.

FASEB J 2019 Feb 22:fj201802020R. Epub 2019 Feb 22.

Department of Emergency Medicine and Chest Pain Center, Qilu Hospital of Shandong University, Jinan, China.

LPS has been shown to elicit neuroinflammation associated with the up-regulation of the eicosanoid pathway in animal models; however, the regulatory mechanisms of TLR4 in brain neuroinflammatory conditions remain elusive. β-Arrestins are key regulators of the GPCR signaling pathway and are involved in the leukotriene B4-induced leukocyte migration to initiate inflammatory response. However, the roles of β-arrestins in eicosanoid regulation and related diseases are not clear. Read More

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http://dx.doi.org/10.1096/fj.201802020RDOI Listing
February 2019

Reactive oxygen species modulate sodium-coupled neutral amino acid transporter 1 (SNAT1) expression in piglet pulmonary artery endothelial cells.

Am J Physiol Heart Circ Physiol 2019 Feb 22. Epub 2019 Feb 22.

Department of Pediatrics, University of Utah Health, United States.

Rationale: We have previously shown that the sodium-coupled neutral amino acid transporter, SNAT1, modulates NO production in pulmonary arterial endothelial cells (PAECs) from newborn piglets. Specifically, the ability to increase NO production in response to the L-arginine-NO precursor, L-citrulline is dependent on SNAT1 expression. Elucidating factors that regulate SNAT1 expression in PAEC could provide new insights and therapeutic targets relevant to NO production. Read More

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http://dx.doi.org/10.1152/ajpheart.00674.2018DOI Listing
February 2019

Non-Invasive Imaging Biomarker Identifies Small Airway Damage in Severe COPD.

Am J Respir Crit Care Med 2019 Feb 22. Epub 2019 Feb 22.

University of Michigan, Pulmonary & Critical Care, Ann Arbor, Michigan, United States ;

Rationale: Evidence suggests damage to small airways is a key pathologic lesion in chronic obstructive pulmonary disease (COPD). Computed Tomography (CT) densitometry has been demonstrated to identify emphysema, but no such studies have been performed linking an imaging metric to small airway abnormality.

Objectives: To correlate ex vivo Parametric Response Mapping (PRM) analysis to in vivo lung tissue measurements of patients with severe COPD treated by lung transplantation and controls. Read More

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http://dx.doi.org/10.1164/rccm.201811-2083OCDOI Listing
February 2019

M1 muscarinic receptors regulate the phosphorylation of AMPA receptor subunit GluA1 via a signaling pathway linking cAMP-PKA and PI3K-Akt.

FASEB J 2019 Feb 22:fj201802351R. Epub 2019 Feb 22.

Institute of Interdisciplinary Integrative Biomedical Research, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

M1 muscarinic acetylcholine receptors are highly expressed in key areas that control cognition, such as the cortex and hippocampus, representing one potential therapeutic target for cognitive dysfunctions of Alzheimer's disease and schizophrenia. We have reported that M1 receptors facilitate cognition by promoting membrane insertion of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor AMPA receptor subunit 1 (GluA1) through phosphorylation at Ser845. However, the signaling pathway is still unclear. Read More

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http://dx.doi.org/10.1096/fj.201802351RDOI Listing
February 2019

Beta-Glucuronidase Catalyzes Deconjugation and Activation of Curcumin-Glucuronide in Bone.

J Nat Prod 2019 Feb 22. Epub 2019 Feb 22.

Department of Pharmacology , Vanderbilt University School of Medicine , Nashville , Tennessee 37232 , United States.

The biological basis for documented in vivo bone-protective effects of turmeric-derived curcumin is unclear since curcumin is barely detectable in serum, being rapidly conjugated to form what is thought to be an inactive glucuronide. Studies were therefore undertaken to test the postulate that antiresorptive effects of curcumin require deconjugation within bone to form the bioactive aglycone and that β-glucuronidase (GUSB), a deconjugating enzyme expressed by hematopoietic marrow cells, facilitates this site-specific transformation. Consistent with this postulate, aglycone, but not glucuronidated, curcumin inhibited RANKL-stimulated osteoclastogenesis, a key curcumin target in bone. Read More

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http://dx.doi.org/10.1021/acs.jnatprod.8b00873DOI Listing
February 2019

Characterization of Analgesic Actions of the Chronic Intrathecal Infusion of H-Dmt-D-Arg-Phe-Lys-NH2 in Rat.

Neuromodulation 2019 Feb 22. Epub 2019 Feb 22.

Department of Anesthesiology, University of California San Diego, La Jolla, CA, USA.

Objectives: DMT-DALDA (H-Dmt-D-Arg-Phe-Lys-NH2; Dmt = 2',6'-dimethyltyrosine) is a selective mu opioid agonist. We sought to characterize efficacy, tolerance, dependence and side-effect profile when given by continuous intrathecal infusion.

Materials And Methods: Adult male Sprague Dawley rats were prepared with chronic intrathecal catheters and osmotic mini-pumps to deliver vehicle (saline), DMT-DALDA or morphine. Read More

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http://dx.doi.org/10.1111/ner.12925DOI Listing
February 2019

Cooperative effects of sequential PGF2α and IL-1β on IL-6 and COX-2 expression in human myometrial cells.

Biol Reprod 2019 Feb 22. Epub 2019 Feb 22.

Department of Physiology, University of Alberta, Edmonton, Alberta, Canada.

Complex cellular and physiological interactions are required to prepare the uterus for birth. The change from the state of pregnancy to the state of parturition, which we call uterine transitioning, requires the actions of inflammatory mediators and results in an activated uterus capable of performing the physiology of labor. Interleukin (IL)-1β and prostaglandin (PG)F2α are two key mediators implicated in preparing the uterus for labor by regulating the expression of uterine activation proteins (UAPs) and pro-inflammatory cytokines and chemokines. Read More

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http://dx.doi.org/10.1093/biolre/ioz029DOI Listing
February 2019

Structural characterization of monoclonal antibodies targeting C-terminal Ser region of phosphorylated tau protein.

MAbs 2019 Feb 22. Epub 2019 Feb 22.

a Departments of Biochemistry & Molecular Pharmacology , New York University School of Medicine , New York , NY , USA.

Targeting tau with immunotherapies is currently the most common approach taken in clinical trials of patients with Alzheimer's disease. The most prominent pathological feature of tau is its hyperphosphorylation, which may cause the protein to aggregate into toxic assemblies that collectively lead to neurodegeneration. Of the phospho-epitopes, the region around Ser/Ser has received particular attention for therapeutic targeting because of its prominence and stability in diseased tissue. Read More

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http://dx.doi.org/10.1080/19420862.2019.1574530DOI Listing
February 2019

Gut microbiota metabolizes nabumetone in vitro: Consequences for its bioavailability in vivo in the rodents with altered gut microbiome.

Xenobiotica 2019 Feb 22:1-7. Epub 2019 Feb 22.

a Department of Medical Chemistry and Biochemistry, Faculty of Medicine and Dentistry , Palacky University Olomouc , Czech Republic.

1. The underlying microbial metabolic activity toward xenobiotics is among the least explored factors contributing to the inter-individual variability in drug response. 2. Read More

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http://dx.doi.org/10.1080/00498254.2018.1558310DOI Listing
February 2019

No correlation between lunar and menstrual cycle - an early report by the french physician J. A. Murat in 1806.

Authors:
Björn Lemmer

Chronobiol Int 2019 Feb 22:1-4. Epub 2019 Feb 22.

a Experimental Pharmacology Mannheim , Ruprecht-Karls-University of Heidelberg , Mannheim , Germany.

Jean Arnaud Murat was a physician at the Medical School of Montpellier in France. In 1806 he published his outstanding book "De L'Influence de la Nuit sur les Maladies ou Traité des Maladies Nocturne". In his book he concentrated on the following questions: - Does the night has an influence on a disease? - Are there diseases in which this is more or less obvious? - What is the physical background of this influence? Murat described in detail certain diseases which dominate at night and he concluded that the most evident motivation for his observations is the constant and periodic movement of the earth around its axis, resulting in a period of about 24 h, and the elliptic rotation around the sun. Read More

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http://dx.doi.org/10.1080/07420528.2019.1583669DOI Listing
February 2019

Single plasmid-based, upgradable and backward compatible adenoviral vector systems.

Hum Gene Ther 2019 Feb 22. Epub 2019 Feb 22.

Chinese Center for Disease Control and Prevention, 12415, National Institute for Viral Disease Control and Prevention, Beijing, China ;

Existing adenoviral vector systems have two drawbacks. It is labor-intensive and time-consuming to load a transgene in these systems, and transgene harboring vectors are dead ends: they cannot be reused to construct a vector carrying another transgene or achieving new characteristics. To conquer these shortcomings, we constructed single plasmid-based adenoviral vector systems where a unique PmeI site was located at the position for insertion of exogenous gene. Read More

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http://dx.doi.org/10.1089/hum.2018.258DOI Listing
February 2019

Redox Imbalance in Idiopathic Pulmonary Fibrosis: A Role for Oxidant Cross-Talk Between NOX Enzymes and Mitochondria.

Antioxid Redox Signal 2019 Feb 22. Epub 2019 Feb 22.

University of Vermont, Pathology , D205 Given Medical Building , 89 Beaumont Avenue , Burlington , Burlington, Vermont, United States , 05405 ;

Significance: Idiopathic pulmonary fibrosis (IPF) is a progressive age-related lung disease with a median survival of only 3 years after diagnosis. The pathogenic mechanisms behind IPF are not clearly understood and current therapeutic approaches have not been successful in improving disease outcomes. Recent advances: IPF is characterized by increased production of reactive oxygen species (ROS), primarily by NADPH oxidases (NOXes) and mitochondria, as well as altered antioxidant defenses. Read More

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http://dx.doi.org/10.1089/ars.2019.7742DOI Listing
February 2019

Exposure to phthalate-containing prescription drugs and the risk of colorectal adenocarcinoma: A Danish nationwide case-control study.

Pharmacoepidemiol Drug Saf 2019 Feb 22. Epub 2019 Feb 22.

Department of Clinical Biochemistry and Pharmacology, Odense University Hospital, Odense, Denmark.

Purpose: Some drug products contain phthalates as excipients, and in vitro studies have demonstrated that phthalates interfere with cellular mechanisms involved in colorectal cancer development. We therefore examined the association between cumulative phthalate exposure from drug products and risk of colorectal adenocarcinomas.

Methods: We used the Danish Cancer Registry to identify all patients with incident colorectal adenocarcinoma from 2008 to 2015 (n = 25 814). Read More

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http://dx.doi.org/10.1002/pds.4759DOI Listing
February 2019

Protein kinase B mediates insulin-like growth factor 1-induced phosphorylation and nuclear export of histone deacetylase 5 via NADPH oxidase 4 activation in vascular smooth muscle cells.

J Cell Physiol 2019 Feb 22. Epub 2019 Feb 22.

Laboratory of Cellular Signaling, Montreal Diabetes Research Center and Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, Canada.

Insulin-like growth factor 1 (IGF-1) mediates the generation of reactive oxygen species (ROS) and the activation of growth promoting signaling pathways. Histone deacetylases (HDACs) regulate gene transcription by deacetylating lysine residues in histone and nonhistone proteins and a heightened HDAC activation, notably of HDAC5, is associated with vascular disorders, such as atherosclerosis. Although the contribution of IGF-1 in these pathologies is well documented, its role in HDAC phosphorylation and activation remains unexplored. Read More

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http://dx.doi.org/10.1002/jcp.28353DOI Listing
February 2019

CSF concentration of ceftriaxone following high-dose administration: pharmacological data from two French cohorts.

J Antimicrob Chemother 2019 Feb 21. Epub 2019 Feb 21.

Infectious Diseases Department, Nantes University Hospital and CIC, INSERM, Nantes, France.

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http://dx.doi.org/10.1093/jac/dkz047DOI Listing
February 2019

Drug-induced systemic lupus: revisiting the ever-changing spectrum of the disease using the WHO pharmacovigilance database.

Ann Rheum Dis 2019 Feb 4. Epub 2019 Feb 4.

AP-HP, Pitié-Salpêtrière Hospital, Department of Pharmacology, Regional Pharmacovigilance Center, INSERM, Sorbonne Universités, Paris, France.

Objective: Drug-induced lupus (DIL) is an idiosyncratic side effect of treatments in which symptoms overlap with those of systemic lupus erythematosus (SLE). The spectrum of DIL constantly evolves with that of the pharmacopoeia. Here, we used VigiBase, the WHO global individual case safety reports (ICSRs) database, to identify the main drugs associated with DIL. Read More

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http://dx.doi.org/10.1136/annrheumdis-2018-214598DOI Listing
February 2019

β-arrestin 2 negatively regulates NOD2 signalling pathway through association with TRAF6 in microglia after cerebral ischaemia/reperfusion injury.

J Cell Mol Med 2019 Feb 22. Epub 2019 Feb 22.

Department of Pharmacology, School of Basic Medical Sciences, Shandong University, Jinan, Shandong, P.R. China.

We previously reported that nucleotide-binding oligomerization domain-containing protein (NOD) 2 was involved in the inflammatory responses to cerebral ischaemia/reperfusion (I/R) insult. However, the mechanism by which NOD2 participates in brain ischaemic injury and the regulation of NOD2 in the process are still obscure. Increased β-arrestin 2 (ARRB2) expression was observed in microglia following cerebral I/R in wild-type mice besides the up-regulation of NOD2 and TRAF6. Read More

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http://dx.doi.org/10.1111/jcmm.14223DOI Listing
February 2019

Setting the beat of an internal clock: Effects of dexamphetamine on different interval ranges of temporal processing in healthy volunteers.

Psych J 2019 Feb 21. Epub 2019 Feb 21.

Faculty of Medicine, Dentistry and Health Sciences, School of Psychiatry and Clinical Neurosciences, University of Western Australia, Crawley, Western Australia, Australia.

Drug studies are powerful models to investigate the neuropharmacological mechanisms underlying temporal processing in humans. This study administered dexamphetamine to 24 healthy volunteers to investigate time perception at different time scales, along with contributions from working memory. Healthy volunteers were administered 0. Read More

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http://dx.doi.org/10.1002/pchj.274DOI Listing
February 2019

A novel role of HuR in -Epigallocatechin-3-gallate (EGCG) induces tumour cells apoptosis.

J Cell Mol Med 2019 Feb 22. Epub 2019 Feb 22.

Department of Clinical Laboratory, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong Province, China.

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http://dx.doi.org/10.1111/jcmm.14249DOI Listing
February 2019

Safety and efficacy of tirofiban combined with endovascular treatment in acute ischemic stroke.

Eur J Neurol 2019 Feb 21. Epub 2019 Feb 21.

Department of Neurology, The First Affiliated Hospital of Chengdu Medical College, Chengdu, 610500, China.

Background: Tirofiban is off-label used in clinical practice for acute ischemic stroke (AIS). However, whether tirofiban increases the bleeding risk or improves the outcome of endovascular treatment (EVT) in AIS is unknown. This study evaluated the efficacy and safety of tirofiban in combination with EVT for AIS. Read More

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http://dx.doi.org/10.1111/ene.13946DOI Listing
February 2019

Neurophysiology and genetics of burning mouth syndrome.

Eur J Pain 2019 Feb 21. Epub 2019 Feb 21.

Department of Clinical Neurophysiology, Turku University Hospital and University of Turku, Finland.

Background And Aims: Neuropathic mechanisms are involved in burning mouth syndrome (BMS), and variation of the dopamine D2 receptor (DRD2) gene contributes to experimental pain perception. We investigated whether neurophysiologic findings differ in BMS patients compared to healthy controls, and whether 957C>T polymorphism of the DRD2 gene influences thermal sensitivity or pain experience in BMS.

Methods: Forty-five BMS patients (43 women), mean age 62. Read More

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http://dx.doi.org/10.1002/ejp.1382DOI Listing
February 2019

Effectiveness of nasal continuous airway pressure therapy in patients with obstructive sleep apnea.

Int J Health Plann Manage 2019 Feb 21. Epub 2019 Feb 21.

Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Kolkata, West Bengal, India.

Objectives: A prospective observational study was carried out with the aim of evaluating the effectiveness of nasal continuous positive airway pressure (nCPAP) therapy on the health-related quality of life (QoL) of patients with obstructive sleep apnea (OSA).

Methods: The patients included in this study were those recently diagnosed with OSA (AHI > 5) and given nCPAP therapy, as well as being referred to a sleep laboratory for an assessment of their sleep disordered breathing. Prior to the start of nCPAP therapy and polysomnography evaluation, patients were asked to complete the validated Quebec sleep questionnaire (QSQ), and their baseline measurements were recorded. Read More

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http://dx.doi.org/10.1002/hpm.2758DOI Listing
February 2019

Effects of vatinoxan on cardiorespiratory function and gastrointestinal motility during constant-rate medetomidine infusion in standing horses.

Equine Vet J 2019 Feb 22. Epub 2019 Feb 22.

Faculty of Veterinary Medicine, Department of Equine and Small Animal Medicine, University of Helsinki, PO Box 57, 00014, Finland.

Background: Medetomidine suppresses cardiovascular function and reduces gastrointestinal motility in horses mainly through peripheral α -adrenoceptors. Vatinoxan, a peripheral α -antagonist, has been shown experimentally to alleviate the adverse effects of some α -agonists in horses. However, vatinoxan has not been investigated during constant-rate infusion (CRI) of medetomidine in standing horses. Read More

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http://dx.doi.org/10.1111/evj.13085DOI Listing
February 2019

Methyl B12 protects PC12 cells against cytotoxicity induced by Aβ.

J Cell Biochem 2019 Feb 21. Epub 2019 Feb 21.

Institute of Pharmacology and Toxicology, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, China.

Alzheimer's disease (AD) is the most common aging-associated dementia. The population of AD patients is increasing as the world age grows. Currently, there is no cure for AD. Read More

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http://dx.doi.org/10.1002/jcb.28475DOI Listing
February 2019

Posthemorrhagic hydrocephalus development after germinal matrix hemorrhage: Established mechanisms and proposed pathways.

J Neurosci Res 2019 Feb 21. Epub 2019 Feb 21.

Department of Physiology and Pharmacology, Loma Linda University School of Medicine, Loma Linda, California.

In addition to being the leading cause of morbidity and mortality in premature infants, germinal matrix hemorrhage (GMH) is also the leading cause of acquired infantile hydrocephalus. The pathophysiology of posthemorrhagic hydrocephalus (PHH) development after GMH is complex and vaguely understood, although evidence suggests fibrosis and gliosis in the periventricular and subarachnoid spaces disrupts normal cerebrospinal fluid (CSF) dynamics. Theories explaining general hydrocephalus etiology have substantially evolved from the original bulk flow theory developed by Dr. Read More

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http://dx.doi.org/10.1002/jnr.24394DOI Listing
February 2019

Prolonged therapy with the anticonvulsant carbamazepine leads to increased plasma clearance of fentanyl.

J Pharm Pharmacol 2019 Feb 21. Epub 2019 Feb 21.

Department of Anesthesiology, Critical Care and Pain Medicine, Boston, MA, USA.

Objectives: Fentanyl is a potent analgesic that accounts for an increasing number of overdose deaths in the United States. This study tested whether altered pharmacokinetics plays a pivotal role in the increased fentanyl dose requirements in patients receiving the enzyme-inducing anticonvulsant, carbamazepine.

Methods: Neurosurgical patients receiving carbamazepine for >6 weeks (N = 11) or no carbamazepine (N = 6, controls) received a single bolus dose of fentanyl (200 μg) intravenously. Read More

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http://dx.doi.org/10.1111/jphp.13079DOI Listing
February 2019
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