6,113,334 results match your criteria Pharmacology & Pharmacy [Journal]

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Continuous intracerebroventricular injection of Porphyromonas gingivalis lipopolysaccharide induces systemic organ dysfunction in a mouse model of Alzheimer's disease.

Exp Gerontol 2019 Feb 17. Epub 2019 Feb 17.

Department of Pharmacology and Molecular Therapeutics, Graduate School of Medical Sciences, Kumamoto University, Japan.

Systemic organ dysfunction is one of the important issues for the patients with Alzheimer's disease (AD) and their caregivers. Recent evidences suggest that periodontitis is a possible risk factor for progression of AD and lipopolysaccharide derived from Porphyromonas gingivalis (Pg-LPS) which is a major periodontopathic bacteria induces cognitive impairment in mice. However, the precise relationships between the brain exposure of Pg-LPS and systemic organ dysfunction in AD patients are still undetermined. Read More

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http://dx.doi.org/10.1016/j.exger.2019.02.007DOI Listing
February 2019

Cholinergic drugs ameliorate endothelial dysfunction by decreasing O-GlcNAcylation via M3 AChR-AMPK-ER stress signaling.

Life Sci 2019 Feb 17. Epub 2019 Feb 17.

Department of Pharmacology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi 710061, People's Republic of China. Electronic address:

Aims: Obesity is associated with increased cardiovascular morbidity and mortality. It is accompanied by augmented O-linked β-N-acetylglucosamine (O-GlcNAc) modification of proteins via increasing hexosamine biosynthetic pathway (HBP) flux. However, the changes and regulation of the O-GlcNAc levels induced by obesity are unclear. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.02.036DOI Listing
February 2019

Rivaroxaban for Thromboprophylaxis in High-Risk Ambulatory Patients with Cancer.

N Engl J Med 2019 02;380(8):720-728

From the Department of Hematology and Medical Oncology, Taussig Cancer Institute and Case Comprehensive Cancer Center, Cleveland Clinic, Cleveland (A.A.K.); the Department of Medicine, Memorial Sloan Kettering Cancer Center (G.A.S., E.M.O.), and Weill Cornell Medical College (G.A.S., E.M.O.), New York; the Thrombosis Research Institute and University College London, London (A.K.K.); University of Texas M.D. Anderson Cancer Center, Houston (S.V.-R.), and U.S. Oncology Research-Texas Oncology, Tyler (H.A.Y.) - both in Texas; the Department of Medicine, Charité Universitätsmedizin Berlin, Berlin (H.R.); the Division of Hematology-Oncology, University of California Davis School of Medicine, Sacramento (T.W.), and the Keck School of Medicine, University of Southern California, Los Angeles (H.A.L.); the Division of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore (M.B.S.); the University of Washington School of Medicine (D.A.G., N.M.K., G.H.L.), Advanced Cancer Research Group (N.M.K.), and Fred Hutchinson Cancer Research Center (G.H.L.), Seattle; Penn State Cancer Institute, Milton S. Hershey Medical Center, Hershey, PA (C.P.B.); the Department of Cancer Pharmacology, Levine Cancer Institute, Atrium Health, Charlotte, NC (J.N.P.); Janssen Scientific Affairs, Titusville (P.W., P.B., S.K.), and Janssen Research and Development, Raritan (U.V.) - both in New Jersey; the Department of Medicine, McMaster University, Hamilton, ON, Canada (J.E.); the Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN (R.M.); and the Division of Hematology-Oncology, Beth Israel Deaconess Medical Center, Boston (K.A.B.).

Background: Ambulatory patients receiving systemic cancer therapy are at varying risk for venous thromboembolism. However, the benefit of thromboprophylaxis in these patients is uncertain.

Methods: In this double-blind, randomized trial involving high-risk ambulatory patients with cancer (Khorana score of ≥2, on a scale from 0 to 6, with higher scores indicating a higher risk of venous thromboembolism), we randomly assigned patients without deep-vein thrombosis at screening to receive rivaroxaban (at a dose of 10 mg) or placebo daily for up to 180 days, with screening every 8 weeks. Read More

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http://dx.doi.org/10.1056/NEJMoa1814630DOI Listing
February 2019

Design of CK2β-mimicking peptides as tools to study the CK2α/CK2β interaction in cancer cells.

ChemMedChem 2019 Feb 20. Epub 2019 Feb 20.

University of Cologne, Department of Pharmacology, Gleueler Strasse 24, 50931, Cologne, GERMANY.

The ubiquitously expressed Ser/Thr kinase CK2 is a key regulator in a variety of key processes in normal and malignant cells. Due to its distinctive anti-apoptotic and tumor-driving properties, elevated levels of CK2 have frequently been found in tumors of different origin. In recent years, development of CK2 inhibitors has largely been focused on ATP-competitive compounds; however, targeting the CK2α/CK2β interface has emerged as a further concept that might avoid selectivity issues. Read More

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http://dx.doi.org/10.1002/cmdc.201800786DOI Listing
February 2019

Suppression of Urinary Voiding "on Demand" by High-Frequency Stimulation of the S1 Sacral Nerve Root in Anesthetized Rats.

Neuromodulation 2019 Feb 20. Epub 2019 Feb 20.

Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, UK.

Objectives: High-frequency (kHz) stimulation of preganglionic pelvic nerve afferents can inhibit voiding in both anesthetized and conscious rats. The afferents travel via the S1 sacral nerve root, which is easier to access than the distal pelvic nerve fibers within the abdominal cavity. We therefore investigated whether voiding could be inhibited by high-frequency stimulation at S1 and how this compared to distal pelvic nerve stimulation. Read More

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http://dx.doi.org/10.1111/ner.12928DOI Listing
February 2019

CARDIAC-SPECIFIC OVEREXPRESSION OF CAVEOLIN-3 PRESERVES T-TUBULAR I DURING HEART FAILURE IN MICE.

Exp Physiol 2019 Feb 20. Epub 2019 Feb 20.

School of Physiology, Pharmacology & Neuroscience, Biomedical Sciences Building, University of Bristol, Bristol, BS8 1TD, UK.

New Findings: What is the central question of this study? Overexpression of caveolin-3 (Cav-3 OE) appears to protect the heart against many of the features of heart failure (HF) normally observed in vivo. The present study investigates the cellular basis of this protection. What is the main finding and its importance? Cav-3 OE has little effect in normal ventricular myocytes but reduces cellular hypertrophy and preserves t-tubular I but not local t-tubular Ca release, in HF induced by pressure-overload in mice. Read More

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http://dx.doi.org/10.1113/EP087304DOI Listing
February 2019

Maternal Transient Receptor Potential Vanilloid 6 (Trpv6) Is Involved In Offspring Bone Development.

J Bone Miner Res 2019 Feb 20:e3646. Epub 2019 Feb 20.

Pharmacology and Toxicology, Center for Molecular Signaling (PZMS), Saarland University School of Medicine, Homburg, Germany.

Embryonic growth and bone development depend on placental Ca transport across the feto-maternal barrier to supply minerals to the fetus. The individual factors and cellular mechanisms that regulate placental Ca transfer, however, are only beginning to emerge. We find that the Ca -selective transient receptor potential vanilloid 6 (TRPV6) channel is expressed in trophoblasts of the fetal labyrinth, in the yolk sac, and in the maternal part of the placenta. Read More

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http://dx.doi.org/10.1002/jbmr.3646DOI Listing
February 2019

Trans ε viniferin decreases amyloid deposits and inflammation in a mouse transgenic Alzheimer model.

PLoS One 2019 20;14(2):e0212663. Epub 2019 Feb 20.

University of Poitiers, EA3808 Neurovascular Unit and Cognitive Disorders, Pôle Biologie Santé, POITIERS, France.

As Alzheimer's disease (AD) induces several cellular and molecular damages, it could be interesting to use multi-target molecules for therapeutics. We previously published that trans ε-viniferin induced the disaggregation of Aβ42 peptide and inhibited the inflammatory response in primary cellular model of AD. Here, effects of this stilbenoid were evaluated in transgenic APPswePS1dE9 mice. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212663PLOS
February 2019
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Sexual dimorphism of acute doxorubicin-induced nephrotoxicity in C57Bl/6 mice.

PLoS One 2019 20;14(2):e0212486. Epub 2019 Feb 20.

Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota, United States of America.

Doxorubicin (DOX) is a chemotherapeutic agent that has been reported to cause nephrotoxicity in rodent models and to a lesser degree in cancer patients. Female rodents have been shown to be protected against several features of DOX-induced nephrotoxicity. Nevertheless, the underlying mechanisms of this sexual dimorphism are not fully elucidated. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212486PLOS
February 2019

Effects of aerobic exercise on molecular aspects of asthma: involvement of SOCS-JAK-STAT.

Exerc Immunol Rev 2019 ;25:50-62

Universidade Brasil, Post-graduation Program in Bioengineering and in Biomedical Engineering, Campus Itaquera, Rua Carolina Fonseca 235, São Paulo - SP, Brazil, 08230-030. Brazilian Institute of Teaching and Research in Pulmonary and Exercise Immunology (IBEPIPE). Rua Pedro Ernesto 240, São José dos Campos - SP, Brazil, 12245-520. Post-Graduation Program in Sciences of Human Movement and Rehabilitation, Federal University of Sao Paulo (UNIFESP), Campus Baixada Santista, Av. Ana Costa, 95 - Vila Mathias - Santos/SP - CEP: 11060-001.

Background: Aerobic training (AT) decreases airway inflammation in asthma, but the underlying cellular and molecular mechanisms are not completely understood. Thus, this study evaluated the participation of SOCS-JAK-STAT signaling in the effects of AT on airway inflammation, remodeling and hyperresponsiveness in a model of allergic airway inflammation.

Methods: C57Bl/6 mice were divided into Control (Co), Exercise (Ex), HDM (HDM), and HDM+Exercise (HDM+ Ex). Read More

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January 2019

Mps1 regulates spindle morphology through MCRS1 to promote chromosome alignment.

Mol Biol Cell 2019 Feb 20:mbcE18090546. Epub 2019 Feb 20.

Arts and Science, New York University at Shanghai, Shanghai, 200122, China.

Accurate partitioning of chromosomes during mitosis is essential for genetic stability and requires the assembly of the dynamic mitotic spindle and proper kinetochore-microtubule attachment. The spindle assembly checkpoint (SAC) monitors the incompleteness and errors in kinetochore-microtubule attachment and delays anaphase. The SAC kinase Mps1 regulates the recruitment of downstream effectors to unattached kinetochores. Read More

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https://www.molbiolcell.org/doi/10.1091/mbc.E18-09-0546
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http://dx.doi.org/10.1091/mbc.E18-09-0546DOI Listing
February 2019
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Contributions of Rho-kinase and AMP-related kinase (AMPK) Signaling Pathways to Endothelium-Derived Contracting Factors (EDCF)-mediated Responses in Diabetic Rat Aorta.

Can J Physiol Pharmacol 2019 Feb 20. Epub 2019 Feb 20.

Bezmialem Vakif Universitesi, 221265, Faculty of Pharmacy Department of Pharmacology , Bezmialem Vakif University Faculty of Pharmacy , Department of Pharmacology , Maltepe , Istanbul, Turkey , 34093 ;

Diabetes-induced endothelium damage leads to vascular dysfunction. The current study was designed to determine the effects of short-term (4-week) streptozotocin (STZ)-induced diabetes on endothelium-derived contracting factors (EDCF)-mediated responses with possible contributions of Rho-kinase and AMP-activated kinase (AMPK) signaling pathways. The effects of STZ-diabetes on vascular functions were examined in isolated thoracic aorta preparations of 30-week-old rats. Read More

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http://dx.doi.org/10.1139/cjpp-2018-0698DOI Listing
February 2019

Identification and Preclinical Pharmacology of ((1R,3S)-1-amino-3-((S)-6-(2-methoxyphenethyl)-5,6,7,8-tetrahydronaphthalen-2-yl)cyclopentyl)methanol (BMS-986166): A Differentiated Sphingosine-1-Phosphate (S1P1) Receptor Modulator Advanced into Clinical Trials.

J Med Chem 2019 Feb 20. Epub 2019 Feb 20.

Recently, our research group reported the identification of BMS-986104 (2) as a differentiated S1P1 receptor modulator. In comparison to fingolimod (FTY720, 1), a full agonist of S1P1 currently marketed for the treatment of relapse remitting multiple sclerosis (RRMS), 2 offers several potential advantages having demonstrated improved safety multiples in pre-clinical evaluations against undesired pulmonary and cardiovascular effects. In clinical trials, 2 was found to exhibit a pharmacokinetic half-life (T1/2) longer than that of 1, as well as a reduced formation of the phosphate metabolite that is required for activity against S1P1. Read More

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http://dx.doi.org/10.1021/acs.jmedchem.8b01695DOI Listing
February 2019

The role of autophagy and lipid catabolism in enhancing cold stress resistance in zebrafish.

J Physiol 2019 Feb 20. Epub 2019 Feb 20.

School of Medicine, Medical University of Warsaw, Warsaw, Poland.

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http://dx.doi.org/10.1113/JP277821DOI Listing
February 2019

SERUM CYTOKINE OF IL-2, IL-10 AND IL-12 LEVELS IN PATIENTS WITH STOMACH ADENOCARCINOMA.

Arq Gastroenterol 2018 Oct-Dec;55(4):385-389

Mazandaran University of Medical Sciences, Faculty of Pharmacy, Department of Toxicology and Pharmacology, Pharmaceutical Research Center, Sari, Iran.

Background: Gastric adenocarcinoma is the fourth most common cause of cancer-associated death worldwide.

Objective: We evaluated the immunological status of patients with gastric cancer before surgery and circulating cytokines as potential diagnostic biomarkers for gastric cancer.

Methods: We included 90 healthy controls and 95 patients with distal Gastric adenocarcinoma in Mazandaran, Sari, Iran. Read More

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http://dx.doi.org/10.1590/S0004-2803.201800000-83DOI Listing

Ruxolitinib treatment reduces monocytic superoxide radical formation without affecting hydrogen peroxide formation or systemic oxidative nucleoside damage in myelofibrosis.

Leuk Lymphoma 2019 Feb 20:1-9. Epub 2019 Feb 20.

b Institute for Inflammation Research (IIR), Center for Rheumatology and Spine Diseases, Rigshospitalet, University of Copenhagen , Copenhagen , Denmark.

The role of excess reactive oxygen species (ROS) with consequent DNA/RNA damage is now recognized as a hallmark of cancer. In JAK2V617F mutated myeloproliferative neoplasms, ROS have been suggested to be important factors in disease initiation and progression. Ruxolitinib is the most widely used drug for myelofibrosis, because it improves symptom-score. Read More

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http://dx.doi.org/10.1080/10428194.2019.1579323DOI Listing
February 2019

A Model of Uric Acid Transport in the Rat Proximal Tubule.

Am J Physiol Renal Physiol 2019 Feb 20. Epub 2019 Feb 20.

Dpt of Pharmacology and Toxicology, University of Lausanne, Switzerland.

The objective of this study was to investigate theoretically the mechanisms underlying uric acid transport in the proximal tubule (PT) of rat kidneys, and their modulation by factors including Na, parathyroid hormone (PTH), Angiotensin II, and SGLT2 inhibitors. To that end, we incorporated the transport of uric acid and its conjugate anion urate in our mathematical model of water and solute transport in the rat PT. The model accounts for parallel urate reabsorption and secretion pathways on apical and basolateral membranes, and their coupling to lactate and alpha-ketoglutarate transport. Read More

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http://dx.doi.org/10.1152/ajprenal.00603.2018DOI Listing
February 2019

Carvedilol attenuates experimentally induced silicosis in rats via modulation of P-AKT/mTOR/TGFβ1 signaling.

Int Immunopharmacol 2019 Feb 20;70:47-55. Epub 2019 Feb 20.

Dep. of Pharmacology and Toxicology, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt. Electronic address:

Silicosis is a well acknowledged occupational lung disorder with considerable negative impact on the patients' quality of life. Various signaling pathways have been reported to interplay in the pathogenesis of pulmonary fibro-proliferative disorders; of which, P-AKT/mTOR signaling pathway. The current study highlights the potential pulmonary protective effect of carvedilol; a non-selective α/β blocker against experimental silicosis-induced in rats by the intranasal installation of silica (50 mg/rat, 1 ml 0. Read More

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http://dx.doi.org/10.1016/j.intimp.2019.02.011DOI Listing
February 2019

Inhibitory effect of valproate sodium on pain behavior in diabetic mice involves suppression of spinal histone deacetylase 1 and inflammatory mediators.

Int Immunopharmacol 2019 Feb 18;70:16-27. Epub 2019 Feb 18.

Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Tabuk, Tabuk, Saudi Arabia; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt. Electronic address:

Anti-epileptic medications are included in the international guidelines for managing neuropathic pain. Valproate sodium (VPS) was recently described as "the forgotten analgesic" and has been reported to relief pain in various models of neuropathic pain. Some studies reported anti-inflammatory and histone deacetylase 1 (HDA1) inhibitory properties for sodium valproate. Read More

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http://dx.doi.org/10.1016/j.intimp.2019.01.050DOI Listing
February 2019

TUDCA-treated chronic kidney disease-derived hMSCs improve therapeutic efficacy in ischemic disease via PrP.

Redox Biol 2019 Feb 16;22:101144. Epub 2019 Feb 16.

Medical Science Research Institute, Soonchunhyang University Seoul Hospital, Seoul 04401, Republic of Korea; Department of Biochemistry, Soonchunhyang University, College of Medicine, Cheonan, 330-930, Republic of Korea. Electronic address:

Although autologous human mesenchymal stem cells (hMSCs) are a promising source for regenerative stem cell therapy in chronic kidney disease (CKD), the barriers associated with pathophysiological conditions limit therapeutic applicability to patients. We confirmed that level of cellular prion protein (PrP) in serum was decreased and mitochondria function of CKD-derived hMSCs (CKD-hMSCs) was impaired in patients with CKD. We proved that treatment of CKD-hMSCs with tauroursodeoxycholic acid (TUDCA), a bile acid, enhanced the mitochondrial function of these cells through regulation of PINK1-PrP-dependent pathway. Read More

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http://dx.doi.org/10.1016/j.redox.2019.101144DOI Listing
February 2019

The muscarinic antagonist gallamine induces proliferation of airway smooth muscle cells regardless of the cell phenotype.

Pharmacol Rep 2018 Oct 23;71(2):225-232. Epub 2018 Oct 23.

Laboratory of Physiology, Department of Medicine, School of Health Sciences, University of Thessaly, BIOPOLIS, Larissa, Greece. Electronic address:

Background: Muscarinic receptor antagonists are a usual treatment for chronic airway diseases, with increased bronchoconstriction, like asthma and chronic obstructive pulmonary disease. These diseases are usually accompanied by airway remodeling, involving airway smooth muscle cell (ASMC) proliferation. The purpose of this study was to examine the effect of the muscarinic receptor modulator gallamine on rabbit tracheal ASMC proliferation. Read More

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http://dx.doi.org/10.1016/j.pharep.2018.10.010DOI Listing
October 2018

Dasatinib significantly reduced in vivo exposure to cyclosporine in a rat model: The possible involvement of CYP3A induction.

Pharmacol Rep 2018 Oct 31;71(2):201-205. Epub 2018 Oct 31.

Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.

Background: This study was designed to investigate the effects of dasatinib and nilotinib on the pharmacokinetics of cyclosporine in rats, as these drugs have been reported to be cytochrome P450 3A4 (CYP3A4) substrates.

Methods: Control and test groups (n = 5) were treated with vehicle and dasatinib (4 mg/kg, and 16 mg/kg, oral) or nilotinib (94 mg/kg, oral), respectively, for 8 consecutive days. On day 8, all groups were administered cyclosporine (30 mg/kg) 1 h after the last dose of dasatinib or nilotinib. Read More

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http://dx.doi.org/10.1016/j.pharep.2018.10.018DOI Listing
October 2018

Curcumin-loaded PLA-PEG copolymer nanoparticles for treatment of liver inflammation in streptozotocin-induced diabetic rats.

Colloids Surf B Biointerfaces 2019 Feb 14;177:389-398. Epub 2019 Feb 14.

Department of Medical Biochemistry, National Research Centre, Giza, Egypt.

This report focused on loading curcumin (CUR) drug into biodegradable Polylactide-poly(ethylene glycol) (PLA-PEG) copolymer nanoparticles as an effective anti-inflammatory agent in vivo to overcome the limitations resulted from the free CUR. By a simple nano-emulsification technique, hydrophobic CUR was loaded into hydrophobic polymer's segments and stabilized by cationic surfactant. They were then characterized by DLS, TEM, and SEM techniques providing monodispersed and spherical nanoparticles with an average diameter of 117 nm and high surface charge of +35 mV. Read More

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http://dx.doi.org/10.1016/j.colsurfb.2019.02.024DOI Listing
February 2019

Effect of intranasal oxytocin on alcohol withdrawal syndrome: A randomized placebo-controlled double-blind clinical trial.

Drug Alcohol Depend 2019 Feb 13;197:95-101. Epub 2019 Feb 13.

Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology - NTNU, Trondheim, Norway; Department of Clinical Pharmacology, St. Olav University Hospital, Trondheim, Norway.

Background: In a pilot study, intranasal oxytocin was demonstrated to reduce the benzodiazepine dose needed to relieve withdrawal symptoms during alcohol detoxification. The aim of the present study was to compare the effect of oxytocin and placebo during a three-day period of alcohol detoxification at an addiction treatment center in Norway.

Methods: Randomized, double-blind, placebo-controlled trial with 40 patients fulfilling criteria for ICD-10 diagnosis of alcohol dependence (F10. Read More

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http://dx.doi.org/10.1016/j.drugalcdep.2019.01.003DOI Listing
February 2019

Cytoprotective effects of olesoxime on isolated human pancreatic islets in order to attenuate apoptotic pathway.

Biomed Pharmacother 2019 Feb 19;112:108674. Epub 2019 Feb 19.

Department of Molecular Medicine, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran; Department of Pharmacology-Toxicology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.

Background And Purpose: Islet transplantation is considered as a promising approach in the treatment of diabetes type 1. In this regard, optimal culture of the pancreatic islets is promising in the success of transplantation. In the present study, the effect of olesoxime, as an antiapoptotic substance, was evaluated on human islet culture. Read More

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http://dx.doi.org/10.1016/j.biopha.2019.108674DOI Listing
February 2019

Bacterial cellulose membrane associated with red propolis as phytomodulator: Improved healing effects in experimental models of diabetes mellitus.

Biomed Pharmacother 2019 Feb 19;112:108640. Epub 2019 Feb 19.

Laboratory of Biotechnology of Natural and Synthetics Products, University of Caxias do Sul, Brazil. Electronic address:

Since early times, propolis has been used in folk medicine. The red propolis, collected in the northeast region of Brazil has been highlighted due to its popular use as an antimicrobial, with anti-inflammatory and healing properties, which are associated with its chemical composition. Here, we combine a bacterial membrane with red propolis to treat wounds of diabetic mice. Read More

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http://dx.doi.org/10.1016/j.biopha.2019.108640DOI Listing
February 2019

Bone marrow mesenchymal stem cells suppress growth and promote the apoptosis of glioma U251 cells through downregulation of the PI3K/AKT signaling pathway.

Biomed Pharmacother 2019 Feb 19;112:108625. Epub 2019 Feb 19.

Key Laboratory of Preclinical Study for New Drugs of Gansu Province, Lanzhou, Gansu, 730000, China; School of Basic Medical Sciences, Lanzhou University, Lanzhou, Gansu, 730000, China. Electronic address:

Mesenchymal stem cells (MSCs), with the capacity for self-renewal and differentiation into multiple cell types, exhibit the property of homing towards tumor sites and immunosuppression and have been used as tumor-tropic vectors for tumor therapy. However, few studies have investigated the underlying molecular mechanisms that link MSCs to targeted tumor cells. In this study, we elucidated the inhibitory effects and mechanisms of human bone marrow mesenchymal stem cells (hBMSCs) on human glioma U251 cells using a co-culture system in vitro. Read More

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http://dx.doi.org/10.1016/j.biopha.2019.108625DOI Listing
February 2019

Network-pharmacology-based identification of caveolin-1 as a key target of Oldenlandia diffusa to suppress breast cancer metastasis.

Biomed Pharmacother 2019 Feb 20;112:108607. Epub 2019 Feb 20.

Integrative Research Laboratory of Breast Cancer, Discipline of Integrated Chinese and Western Medicine, the Research Center of Integrative Medicine, School of Basic Medical Sciences & the Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China; Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome, Guangdong Provincial Academy of Chinese Medical Sciences, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, Guangdong, China; Post-doctoral Research Center, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China. Electronic address:

Background: Breast cancer remains the most common female malignancy and metastasis is the leading cause of death in breast cancer patients. Oldenlandia diffusa has been empirically and extensively used as an adjuvant therapy for metastatic breast cancer patients in Traditional Chinese Medicine (TCM) with proven efficacy. However, its anti-metastasis mechanism has been poorly revealed. Read More

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http://dx.doi.org/10.1016/j.biopha.2019.108607DOI Listing
February 2019

Evaluation of biochemical mechanisms of anti-diabetic functions of Anisomeles malabarica.

Biomed Pharmacother 2019 Feb 19;112:108598. Epub 2019 Feb 19.

Department of Biochemistry, Sri Venkateswara University, Tirupati, AP, India. Electronic address:

Anisomeles malabarica (AM) is an aromatic plant traditionally used for the treatment of diabetes mellitus in India. Following bioassay guided fractionation, we recently identified an active fraction of AM (AMAF, with potential mix of active principles) that showed significant antihyperglycemic and antihyperlipidemic activities. In addition, AMAF treatment improved insulin levels. Read More

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http://dx.doi.org/10.1016/j.biopha.2019.01.059DOI Listing
February 2019

Par3 regulates polarized convergence between APP and BACE1 in hippocampal neurons.

Neurobiol Aging 2019 Jan 30;77:87-93. Epub 2019 Jan 30.

Department of Neuroscience and Cell Biology, Rutgers Robert Wood Johnson Medical School, Piscataway, NJ, USA. Electronic address:

The convergence between amyloid precursor protein (APP) and its β-secretase β-site APP cleaving enzyme 1 (BACE1) is a prerequisite for the generation of β-amyloid peptide, a key pathogenic agent for Alzheimer's disease. Yet the underlying molecular mechanisms regulating their convergence remain unclear. Here, we show that the polarity protein partitioning-defective 3 (Par3) regulates the polarized convergence between APP and BACE1 in hippocampal neurons. Read More

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http://dx.doi.org/10.1016/j.neurobiolaging.2019.01.023DOI Listing
January 2019

Molecular and functional insights into Transient Receptor Potential Vanilloid 1 (TRPV1) in bull spermatozoa.

Theriogenology 2019 Feb 5;128:207-217. Epub 2019 Feb 5.

Department of Veterinary Physiology, College of Veterinary Science & Animal Husbandry, U.P. Pandit Deendayal Upadhayaya Pashu Chikitsa Vigyan Vishwavidyalaya Evam Go Anusandhan Sansthan, Mathura, 281001, Uttar Pradesh, India. Electronic address:

In view of the limited information available on functional significance of TRPV1 in regulating sperm functions, present study was undertaken on bull spermatozoa. Sixty four ejaculates were collected from four Hariana bulls and were used for molecular and functional characterisation of TRPV1. Immunoblotting using TRPV1 specific antibody revealed the presence of a single band of 104 kDa corresponding to TRPV1 in Hariana bull spermatozoa. Read More

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http://dx.doi.org/10.1016/j.theriogenology.2019.01.029DOI Listing
February 2019

C1-esterase inhibitor enhances thrombin generation and spatial fibrin clot propagation in the presence of thrombomodulin.

Thromb Res 2019 Feb 12;176:54-60. Epub 2019 Feb 12.

Laboratory of Biochemistry and Vascular Biology, Center for Biologics Evaluation Research, US Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, MD, United States.

Package inserts for C1-esterase inhibitor (C1INH) products include warnings for an elevated risk of possible thrombosis in certain individuals, referring to thromboembolic events (TEEs) that were reported to occur after C1INH infusions. However, the mechanism(s) that could explain possible development of TEEs due to C1INH remains unknown. In this work, we evaluated plausible impact of C1INH on the protein C (PC) anticoagulant system. Read More

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http://dx.doi.org/10.1016/j.thromres.2019.02.013DOI Listing
February 2019

Study of antidepressant use in 5 European settings. Could economic, sociodemographic and cultural determinants be related to their use?

J Affect Disord 2019 Feb 6;249:278-285. Epub 2019 Feb 6.

Hospital Universitari Vall d'Hebron, Barcelona, Spain; Fundació Institut Català de Farmacologia, Passeig de la Vall d'Hebron, 119-129, 08035, Barcelona, Spain; Department of Clinical Pharmacology, Therapeutics and Toxicology, Universitat Autònoma de Barcelona, Bellaterra, Spain. Electronic address:

Background: We aimed at describing the trends in antidepressants use (AD) by age and sex, during 2007-2011, in 5 European settings (Sweden, Norway, Denmark, Catalonia and Veneto), and to assess whether the differences found across settings could be related to economic, social and cultural determinants.

Methods: We collected data of AD use expressed in defined daily doses (DDD). Data were retrieved from population-based databases. Read More

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http://dx.doi.org/10.1016/j.jad.2019.01.039DOI Listing
February 2019

Incretin Physiology and Pharmacology in the Intensive Care Unit.

Crit Care Clin 2019 Apr 24;35(2):341-355. Epub 2019 Jan 24.

Intensive Care Unit, Royal Melbourne Hospital, 300 Grattan Street, Parkville, Victoria 3050, Australia; Intensive Care, University of Melbourne, 300 Grattan Street, Parkville, Victoria 3050, Australia.

In health, postprandial glycemic excursions are attenuated via stimulation of insulin secretion, suppression of glucagon secretion, and slowing of gastric emptying. The incretin hormones, glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide, are primary modulators of this response. Drugs have recently been developed that exploit the incretin-axis for the management of type 2 diabetes. Read More

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http://dx.doi.org/10.1016/j.ccc.2018.11.011DOI Listing

Hemoglobin A1c and Permissive Hyperglycemia in Patients in the Intensive Care Unit with Diabetes.

Crit Care Clin 2019 Apr 24;35(2):289-300. Epub 2019 Jan 24.

Department of Physiology and Pharmacology, Section of Anaesthesia and Intensive Care, Karolinska Institutet, Solnavägen 9, Stockholm, 171 65 Solna, Sweden; Function Perioperative Medicine and Intensive Care, Karolinska University Hospital, Stockholm 171 76, Sweden. Electronic address:

Glycated hemoglobin A1c can be used to assess intensive care unit patients' level of chronic glycemic control. Compared with patients with normal glycated hemoglobin A1c, patients with elevated glycated hemoglobin A1c seem to better tolerate hyperglycemia and large glucose fluctuations during critical illness. The risks associated with hypoglycemia are markedly greater among patients with elevated glycated hemoglobin A1c. Read More

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http://dx.doi.org/10.1016/j.ccc.2018.11.010DOI Listing

Autism and Schizophrenia-Associated CYFIP1 Regulates the Balance of Synaptic Excitation and Inhibition.

Cell Rep 2019 Feb;26(8):2037-2051.e6

Department of Neuroscience, Physiology and Pharmacology, University College London, Gower Street, London WC1E 6BT, UK. Electronic address:

Altered excitatory/inhibitory (E/I) balance is implicated in neuropsychiatric and neurodevelopmental disorders, but the underlying genetic etiology remains poorly understood. Copy number variations in CYFIP1 are associated with autism, schizophrenia, and intellectual disability, but its role in regulating synaptic inhibition or E/I balance remains unclear. We show that CYFIP1, and the paralog CYFIP2, are enriched at inhibitory postsynaptic sites. Read More

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http://dx.doi.org/10.1016/j.celrep.2019.01.092DOI Listing
February 2019

Addition of grape pomace flour in the diet on laying hens in heat stress: Impacts on health and performance as well as the fatty acid profile and total antioxidant capacity in the egg.

J Therm Biol 2019 Feb 10;80:141-149. Epub 2019 Jan 10.

Department of Animal Science, Universidade do Estado de Santa Catarina, Chapecó, SC, Brazil; Graduate Program of Animal Science, Universidade do Estado de Santa Catarina, Chapecó, SC, Brazil; Graduate Program in Toxicological Biochemistry, Universidade Federal de Santa Maria, Santa Maria (UFSM), Brazil. Electronic address:

The aim of this study was to evaluate whether the addition of grape pomace flour (GPF) in the diet of laying hens at the end of the productive cycle and on heat stress could exert benefits on their health and performance, as well as egg quality. For this, 74-week-old laying hens (n = 64) were divided into four groups with four repetitions each, as follow: T0 (the control group; without GPF), T1 (1% GPF), T2 (2% GPF) and T3 (3% GPF) during 35 days. Percentage of laid eggs was higher in the group T1 compared to T0, and the feed intake was higher in the groups T1, T2 and T3 compared to T0. Read More

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http://dx.doi.org/10.1016/j.jtherbio.2019.01.003DOI Listing
February 2019

Melanocortin 3 receptor gene polymorphism is associated with polycystic ovary syndrome in Turkish population.

Gynecol Endocrinol 2019 Feb 20:1-6. Epub 2019 Feb 20.

h Department of Pharmacology , Sivas Numune Hospital , Sivas , Turkey.

Polycystic ovary syndrome (PCOS) is a frequent complex disorder with an ill-defined etiology. Genetic factors seem rather effective at the occurrence of the disease, however, the evidence of established various studies results are unsatisfied. We aimed to make a contribution to the genetic baseline of the disease by investigating melanocortin 3 receptor gene polymorphism in affected patients. Read More

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http://dx.doi.org/10.1080/09513590.2019.1576614DOI Listing
February 2019

Protective effects of whey on rat liver damage induced by chronic alcohol intake.

Hum Exp Toxicol 2019 Feb 20:960327119829518. Epub 2019 Feb 20.

9 Institute of Pharmacology and toxicology, University of Priština, City of Kosovska Mitrovica, Serbia.

In 2012, alcohol liver disease resulted in 3.3 million-5.9% of global deaths. Read More

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http://journals.sagepub.com/doi/10.1177/0960327119829518
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http://dx.doi.org/10.1177/0960327119829518DOI Listing
February 2019
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Phase I study of PF-04895162, a Kv7 channel inhibitor, reveals unexpected hepatotoxicity in healthy subjects, but not rats or monkeys: clinical evidence of disrupted bile acid homeostasis.

Pharmacol Res Perspect 2019 Feb;7(1):e00467

Clinical Pharmacology, Early Clinical Development, Pfizer Inc., Cambridge, UK.

During a randomized Phase 1 clinical trial the drug candidate, PF-04895162 (ICA-105665), caused transaminase elevations (≥grade 1) in six of eight healthy subjects treated at 300 mg twice daily for 2-weeks (NCT01691274). This was unexpected since studies in rats (<6 months) and cynomolgus monkeys (<9 months) treated up to 100 mg/kg/day did not identify the liver as a target organ. Mechanistic studies showed PF-04895162 had low cytotoxic potential in human hepatocytes, but inhibited liver mitochondrial function and bile salt export protein (BSEP) transport. Read More

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http://dx.doi.org/10.1002/prp2.467DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370995PMC
February 2019

Role of glucocorticoids on noradrenergic and dopaminergic neurotransmission within the basolateral amygdala and dentate gyrus during morphine withdrawal place aversion.

Addict Biol 2019 Feb 19. Epub 2019 Feb 19.

Department of Pharmacology, University of Murcia, Murcia, Spain.

Aversive memories related to drug withdrawal can generate a motivational state leading to compulsive drug taking. However, the mechanisms underlying the generation of these withdrawal memories remain unclear. Limbic structures, such as the basolateral amygdala (BLA) and the dentate gyrus (DG) of the hippocampus, play a crucial role in the negative affective component of morphine withdrawal. Read More

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http://dx.doi.org/10.1111/adb.12728DOI Listing
February 2019

Short Survival and Frequent Transformation in Extranodal Marginal Zone Lymphoma with Multiple Mucosal Sites Presentation.

Am J Hematol 2019 Feb 19. Epub 2019 Feb 19.

Department of Medicine, Division of Hematology, University of Miami, Miller School of Medicine, Miami, FL, USA.

Between 11-37% of extranodal marginal zone lymphoma (EMZL) patients present with disease involvement in multiple mucosal sites (MMS). We analyzed 405 EMZL patients seen between 1995 and 2017. 265 (65. Read More

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http://dx.doi.org/10.1002/ajh.25446DOI Listing
February 2019

The Dexcom glucose monitoring system - an isobornyl acrylate free alternative for Diabetes patients.

Contact Dermatitis 2019 Feb 19. Epub 2019 Feb 19.

Department of Conservative Dentistry and Periodontology, University Hospital, LMU Munich, Germany.

Background: Glucose monitoring systems, eg Freestyle Libre (Abott) and Dexcom (Nintamed) more and more replace conventional blood sugar measurement. However, many patients experienced adverse skin reactions such as severe allergic contact dermatitis (ACD). Finally, in August 2017 the culprit allergen in Freestyle Libre, isobornyl acrylate (IBOA), was identified. Read More

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http://dx.doi.org/10.1111/cod.13248DOI Listing
February 2019

SNX9 determines the surface levels of integrin β1 in vascular endothelial cells: Implication in poor prognosis of human colorectal cancers overexpressing SNX9.

J Cell Physiol 2019 Feb 19. Epub 2019 Feb 19.

Department of Biochemistry and Molecular Genetics, Ehime University Graduate School of Medicine, Ehime, Japan.

Angiogenesis, the formation of new blood vessels, is involved in a variety of diseases including the tumor growth. In response to various angiogenic stimulations, a number of proteins on the surface of vascular endothelial cells are activated to coordinate cell proliferation, migration, and spreading processes to form new blood vessels. Plasma membrane localization of these angiogenic proteins, which include vascular endothelial growth factor receptors and integrins, are warranted by intracellular membrane trafficking. Read More

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http://dx.doi.org/10.1002/jcp.28346DOI Listing
February 2019

The pathogen-reduced red blood cell suspension: single centre study of clinical safety and efficacy in children with oncological and haematological diseases.

Vox Sang 2019 Feb 19. Epub 2019 Feb 19.

National Medical Research Center for Pediatric Hematology, Oncology and Immunology, Moscow, Russia.

Background: Transmission of pathogens through blood transfusion is still of great concern to clinicians, patients and blood providers. Pathogen reduction technologies (PRT) have been successfully applied for the treatment of labile blood components, such as plasma, platelets and whole blood (WB), which are now used in routine in many countries. We report the clinical evaluation of suspension of red blood cells (RBC-S) derived from the WB treated with riboflavin and UV light (RF+UV). Read More

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http://dx.doi.org/10.1111/vox.12757DOI Listing
February 2019

Intra-articular mucilages: behavioural and histological evaluations for a new model of articular pain.

J Pharm Pharmacol 2019 Feb 19. Epub 2019 Feb 19.

NEUROFARBA - Pharmacology and Toxicology Section, Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy.

Objectives: The creation of a new valid preclinical model of articular pain by the intra-articular (i.a.) injection of mucilages for the screening of new treatments against arthritis. Read More

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http://dx.doi.org/10.1111/jphp.13078DOI Listing
February 2019

Systematic review and meta-analysis of randomized controlled trials of atosiban versus nifedipine for inhibition of preterm labor.

Int J Gynaecol Obstet 2019 Feb 19. Epub 2019 Feb 19.

Pharmacology Department, Faculty of Veterinary Medicine, Suez Canal University, Ismailia, Egypt.

Background: Two tocolytic drugs- atosiban and nifedipine-are currently used for first-line treatment of preterm labor (PTL).

Objective: To compare the efficacy and safety of atosiban with nifedipine for PTL treatment.

Search Strategy: In May 2017, we searched PubMed, Scopus, Web of Science, and Cochrane Central Register of Controlled Clinical Trials with search terms including "nifedipine", "atosiban", and "preterm labor". Read More

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http://dx.doi.org/10.1002/ijgo.12793DOI Listing
February 2019

Underwire bra complicating a gunshot injury.

Can J Anaesth 2019 Feb 19. Epub 2019 Feb 19.

Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.1007/s12630-019-01319-6DOI Listing
February 2019

AAV-Mediated Gene Delivery to the Enteric Nervous System by Intracolonic Injection.

Methods Mol Biol 2019 ;1950:407-415

Department of Neuroscience, University of Minnesota, Minneapolis, MN, USA.

The enteric nervous system of the lower gastrointestinal tract comprises intrinsic neural circuits as well as extrinsic afferent and efferent innervation. The development of strategies for neuronal gene transfer has created new opportunities for functional analysis, circuit mapping, and neuromodulation in the enteric nervous system. Studies of AAV-mediated gene transfer to enteric neurons and dorsal root ganglion neurons (DRG) have provided proofs-of-concept for the utility of AAV vectors for genetic manipulations of the intrinsic and extrinsic components of the enteric nervous system. Read More

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http://dx.doi.org/10.1007/978-1-4939-9139-6_24DOI Listing
January 2019
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