4,576 results match your criteria Pharmacology[Journal]


A Comparison of the Anti-Inflammatory Effects of Four Combined Statin and Antiplatelet Therapies on Tumor Necrosis Factor-Mediated Acute Inflammation in vivo.

Pharmacology 2019 Apr 10;104(1-2):21-27. Epub 2019 Apr 10.

Laboratory of PharmacoImmunology, Integrated Research Institute of Pharmaceutical Sciences, BK21 PLUS Team for Creative Leader Program for Pharmacomics-based Future Pharmacy, College of Pharmacy, The Catholic University of Korea, Bucheon, Republic of Korea,

Background: Combination therapy has been administered to patients with chronic or complex diseases due to its improved therapeutic effects compared with the results of monotherapy. Due to the pleiotropic effects of statins and antiplatelets, these drugs have been studied in combination with other drugs, but not all combinations exerted obvious beneficial effects compared with individual drugs. In this study, we aimed to compare the anti-inflammatory effects of 4 different combination therapies of statins and antiplatelets on the tumor necrosis factor (TNF)-mediated inflammation in vivo. Read More

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http://dx.doi.org/10.1159/000499335DOI Listing

Pharmacokinetic Characterizations of Ginsenoside Ocotillol, RT5 and F11, the Promising Agents for Alzheimer's Disease from American Ginseng, in Rats and Beagle Dogs.

Pharmacology 2019 Apr 4;104(1-2):7-20. Epub 2019 Apr 4.

Department of Clinical Laboratory, The Second Affiliated Hospital of Dalian Medical University, Dalian, China,

Background: Ocotillol, RT5 and F11, the main active components of ocotillol type ginsenosides, have attracted a lot of attention due to their beneficial effects on neurodegenerative disease models of Alzheimer's disease. Pharmacokinetic (PK) is a bridge linking the herbal medicines and their pharmacological responses. However, few data are available regarding PK behaviors of ocotillol type ginsenosides. Read More

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http://dx.doi.org/10.1159/000499595DOI Listing

Administration of Curcumin Alleviates Neuropathic Pain in a Rat Model of Brachial Plexus Avulsion.

Pharmacology 2019 3;103(5-6):324-332. Epub 2019 Apr 3.

Department of Anesthesiology, Quanzhou First Hospital, Quanzhou, China.

Background/aims: Brachial plexus avulsion (BPA) generally causes a chronic persistent pain that lacks efficacious treatment. Curcumin has been found to possess anti-inflammatory abilities. However, little is known about the mechanisms and effects of curcumin in an animal model of BPA. Read More

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http://dx.doi.org/10.1159/000496928DOI Listing
April 2019
1 Read

Effect of Evening Bromazepam Administration on Blood Pressure and Heart Rate in Mild Hypertensive Patients.

Pharmacology 2019 Apr 3;104(1-2):1-6. Epub 2019 Apr 3.

Interinstitutional Center of Neurological Medicine, IRCCS National Neurological Institute C. Mondino Foundation, Pavia, Italy,

Aim: To assess the effects of chronic evening oral administration of bromazepam alone or in combination with propranolol on ambulatory blood pressure (BP) and heart rate (HR) in mild hypertensive subjects.

Methods: Thirty-seven mild hypertensive patients after a 2-week placebo period were randomized to bromazepam 3 mg, propranolol 40 mg, bromazepam 3 mg plus propranolol 40 mg or placebo for 2 weeks according to a double-blind, double dummy, cross-over design. After each treatment period, 24-h BP and HR ambulatory monitoring was performed by using a non-invasive device. Read More

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http://dx.doi.org/10.1159/000499371DOI Listing

High-Level Mupirocin Resistance in Staphylococcus spp. among Health Care Workers in a Tertiary Care Hospital.

Pharmacology 2019 19;103(5-6):320-323. Epub 2019 Mar 19.

Department of Microbiology, Centre for Research, Sri Lakshmi Narayana Institute of Medical Sciences and Research, Pondicherry, India.

Background: Nasal carriage of Staphylococcus aureus is very common among health care workers, and treatment with mupirocin is one of the choicest antibiotics available. But with the rampant usage of mupirocin like other antibiotics, the emergence of mupirocin resistance is also on rise. This resistance is both low level as well as high level among the isolated strains. Read More

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http://dx.doi.org/10.1159/000499022DOI Listing

Effect of Caffeic Acid on Ischemia-Reperfusion-Induced Acute Renal Failure in Rats.

Pharmacology 2019 14;103(5-6):315-319. Epub 2019 Mar 14.

Department of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, India,

Background: Cyclooxygenase (COX)-lipooxygenase (LOX) pathway plays a key role in the pathogenesis of renal ischemia/reperfusion (IR).

Objective: This study was aimed to evaluate the role of dietary phenol caffeic acid (CA), alone and in combination with selective COX-2 inhibitor celecoxib (CEL) in IR-induced acute renal failure (ARF) in rats.

Materials And Methods: Renal IR was induced by bilateral occlusion of renal pedicels for 90 min followed by reperfusion for 24 h. Read More

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http://dx.doi.org/10.1159/000497474DOI Listing
March 2019
3 Reads

Epigallocatechin-3-Gallate Attenuates Adriamycin-Induced Focal Segmental Glomerulosclerosis via Suppression of Oxidant Stress and Apoptosis by Targeting Hypoxia-Inducible Factor-1α/ Angiopoietin-Like 4 Pathway.

Authors:
Guoyong Liu Liyu He

Pharmacology 2019 6;103(5-6):303-314. Epub 2019 Mar 6.

Department of Nephrology, The Second Xiangya Hospital, Central South University, Key Lab of Kidney Disease and Blood Purification in Hunan, Changsha, China,

Background: Focal and segmental glomerular sclerosis (FSGS) is a common cause of nephrotic syndrome and end-stage renal disease. It has been reported that overproduction of reactive oxygen species (ROS) and cell apoptosis are associated with the development of FSGS. Epigallocatechin-3-gallate (EGCG) is a bioactive constituent accounting for more than 50% of the total catechins in green tea, which have anti-oxidative and anti-apoptotic effects. Read More

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http://dx.doi.org/10.1159/000496799DOI Listing
March 2019
1 Read

Cardioprotective Effect of Rhapontigenin in Isoproterenol-Induced Myocardial Infarction in a Rat Model.

Authors:
Ying Fan

Pharmacology 2019 28;103(5-6):291-302. Epub 2019 Feb 28.

Department of Cardiovascular Medicine, Inner Mongolia People's Hospital, Inner Mongolia Autonomous Region, Hohhot, China,

Background/aims: Rhapontigenin (RPG) is a stilben derivative and is known to bear several effects such as antiallergic, anticoagulative, hypoglycemic, antiangiogenic, and purgative. The investigation was conducted to evaluate the cardioprotective efficacy of RPG in rats having acute myocardial infarction (MI) induced by isoproterenol (ISO).

Methods: Animals were divided into 6 groups: group I (control group), group II (ISO-treated), group III (1. Read More

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http://dx.doi.org/10.1159/000496800DOI Listing
February 2019
1 Read

Genistein Protects H9c2 Cardiomyocytes against Chemical Hypoxia-Induced Injury via Inhibition of Apoptosis.

Pharmacology 2019 26;103(5-6):282-290. Epub 2019 Feb 26.

School of Pharmacy, Hunan University of Chinese Medicine, Changsha, China,

Background/aims: Hypoxia can induce cell injury in cardiomyocytes and further lead to cardiovascular diseases. Genistein (Gen), the predominant isoflavone found in soy products, has shown protective effects on cardiovascular system. The aim of the present study was to investigate the cardioprotective effect of Gen against chemical hypoxia-induced injury. Read More

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http://dx.doi.org/10.1159/000497061DOI Listing
February 2019
2 Reads

Design and Discovery of Novel 1,3,5-Triazines as Dipeptidyl Peptidase-4 Inhibitor against Diabetes.

Pharmacology 2019 21;103(5-6):273-281. Epub 2019 Feb 21.

Department of Nephrology, The First Affiliated Hospital of Jinan University, Guangzhou, China,

This study aims at synthesizing novel di-morpholine 1,3,5-triazine derivatives as antidiabetic agent via inhibition of dipeptidyl peptidase-4 (DPP-4). The molecules were developed via sequential nucleophilic reaction to afford target derivatives 5(a-f) and subsequently tested for inhibitory potency against DPP iso-enzymes, such as DPP-4, DPP-8, and DPP-9. The in vitro inhibition assay suggested that these derivatives prominently and selectively inhibit DPP-4 over -DPP-8 and DPP-9. Read More

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http://dx.doi.org/10.1159/000494060DOI Listing
February 2019
1 Read

Multiple Signal Pathways Involved in Crocetin-Induced Apoptosis in KYSE-150 Cells.

Pharmacology 2019 15;103(5-6):263-272. Epub 2019 Feb 15.

Department of Anatomy and Neurobiology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China,

Background: Crocetin is a carotenoid extracted from the traditional Chinese medical herb saffron. Previous studies have demonstrated that crocetin possesses anticancer properties that are effective against various cancers. As an extension of our earlier study, the present study explored the underlying mechanisms in crocetin's anticancer effect on KYSE-150 cells. Read More

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http://dx.doi.org/10.1159/000487956DOI Listing
February 2019

Suppression of KCNQ/M Potassium Channel in Dorsal Root Ganglia Neurons Contributes to the Development of Osteoarthritic Pain.

Pharmacology 2019 13;103(5-6):257-262. Epub 2019 Feb 13.

Department of Orthopaedic Surgery, Institute of Biomechanical Science, Biomechanical Key Laboratory of Hebei Province, Third Hospital of Hebei Medical University, Shijiazhuang, China,

Osteoarthritic pain has a strong impact on patients' quality of life. Understanding the pathogenic mechanisms underlying osteoarthritic pain will likely lead to the development of more effective treatments. In the present study of osteoarthritic model rats, we observed a reduction of M-current density and a remarkable decrease in the levels of KCNQ2 and KCNQ3 proteins and mRNAs in dorsal root ganglia (DRG) neurons, which were associated with hyperalgesic behaviors. Read More

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http://dx.doi.org/10.1159/000496422DOI Listing
February 2019
1 Read

Antifibrotic Agent Pirfenidone Suppresses Proliferation of Human Pancreatic Cancer Cells by Inducing G0/G1 Cell Cycle Arrest.

Pharmacology 2019 7;103(5-6):250-256. Epub 2019 Feb 7.

Department of Oncologic Pathology, Mie University, Tsu, Japan.

Background: Pirfenidone (PFD), which is an antifibrotic agent used for treatment of idiopathic pulmonary fibrosis, induces G0/G1 cell cycle arrest in fibroblasts. We hypothesized that PFD-induced G0/G1 cell cycle arrest might be achieved in other types of cells, including cancer cells. Here we investigated the effects of PFD on the proliferation of pancreatic cancer cells (PCCs) in vitro. Read More

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http://dx.doi.org/10.1159/000496831DOI Listing
February 2019
6 Reads

Comparison of Active Substance Losses and Total Weight Losses of Tablets Administered Via Feeding Tube.

Pharmacology 2019 6;103(5-6):246-249. Epub 2019 Feb 6.

Clinical Pharmacology Unit, Department of Anaesthesia and Intensive Care, International Clinical Research Center, St. Anne's University Hospital Brno, Brno, Czech Republic,

Background/aims: Administration of tablets via feeding tube (FT) is often associated with significant drug losses, as was confirmed by weighing. The aim of this study was to measure the proportion of active substance losses (ASLs) in an in vitro model.

Methods: A film-coated tablet (FilmCT) containing clopidogrel (Trombex®) and a tablet with enteric coating (EntericCT) containing pantoprazole (Controloc®) were crushed in a mortar and transferred by method A (tablet powder was transferred into the beaker, poured into the syringe and water added) and method B (water was added into the mortar, suspension drawn into the syringe) and administered via FT in an in vitro model. Read More

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http://dx.doi.org/10.1159/000496423DOI Listing
February 2019
2 Reads

Probucol Slows the Progression of Cataracts in Streptozotocin-Induced Hyperglycemic Rats.

Pharmacology 2019 5;103(3-4):212-219. Epub 2019 Feb 5.

Department of Molecular Pharmacology, Kitasato University School of Pharmaceutical Sciences, Tokyo, Japan,

We examined the effect of probucol, an antihyperlipidemic drug with potent antioxidant properties, on cataract formation in streptozotocin (STZ)-induced hyperglycemic rats that were given 5% D-glucose as drinking water. Probucol treatment was initiated immediately after the induction of hyperglycemia was confirmed. Using full horizontal-plane lens images captured with an original digital camera system, the opacity of central region of lens was assessed by measuring the opaque area in the region. Read More

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http://dx.doi.org/10.1159/000496055DOI Listing

Chronic Addiction to Tramadol and Withdrawal Effect on the Spermatogenesis and Testicular Tissues in Adult Male Albino Rats.

Pharmacology 2019 30;103(3-4):202-211. Epub 2019 Jan 30.

Department of Biology, College of Science, Majmaah University, Majmaah, Al-Zulfi, Saudi Arabia.

Aim: The present study aimed to elucidate the effects of tramadol on the testicular functions of adult male rats due to the chronic usage of tramadol and the effect of its withdrawal.

Method: Adult male albino rats were classified into the following 3 groups: (I) a control administered with normal saline and (II) tramadol-treated rats (40 mg/kg b.w. Read More

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http://dx.doi.org/10.1159/000496424DOI Listing

Shenduning Granule Attenuates Renal Injury from Oxidative Stress through the Nuclear Factor Erythroid 2-Related Factor 2/Antioxidant Response Element Pathway.

Pharmacology 2019 30;103(5-6):236-245. Epub 2019 Jan 30.

Department of Nephropath, Jinhua Hospital of Traditional Chinese Medicine, Jinhua, China.

Background: Systemic oxidative stress has been reported to play a central role in the pathogenesis of kidney function decline. The nuclear factor erythroid 2-related factor 2 (Nrf2)/antioxidant response element (ARE) pathway is one of the important endogenous antioxidant stress pathways in cells. This study aims to investigate whether shenduning granule can ameliorate oxidative stress in kidney tissues by activating the Nrf2/ARE pathway, and explores the detailed underlying mechanism. Read More

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http://dx.doi.org/10.1159/000494981DOI Listing
January 2019

Effect of Verapamil on Kidney Function Using Radionuclide Imaging.

Pharmacology 2019 29;103(3-4):173-178. Epub 2019 Jan 29.

Department of Biomedical Sciences, College of Nursing, Public Authority for Applied Education and Training, Kuwait, Kuwait.

Background And Objective: Calcium channel blockers (CCBs) are among the most widely used prescribed drugs for the treatment of cardiovascular diseases. The present study investigates the effect of verapamil, which is most commonly used as a CCB, on kidney function using radionuclide imaging.

Methods: Ten New Zealand white rabbits were used in vitro (4) and in vivo (6) studies. Read More

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http://dx.doi.org/10.1159/000495617DOI Listing
March 2019
1 Read

Iron Chelation as Novel Treatment for Interstitial Cystitis.

Pharmacology 2019 29;103(3-4):159-162. Epub 2019 Jan 29.

Department of Pharmacology, Dalhousie University, Halifax, Nova Scotia, Canada,

Interstitial cystitis (IC) is a highly prevalent debilitating disease, with its cardinal symptoms being severe pain, urinary urgency and frequency. The associated pain may eventually lead as a last resort to removal of the bladder. Though the initial trigger for IC remains largely unknown, we propose novel iron chelators as a possible new treatment for this disease. Read More

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http://dx.doi.org/10.1159/000496089DOI Listing
March 2019
2 Reads

Evaluation of Antidepressant Effects on Recovery of Electrical Field Stimulation-Induced Contractions that have been Suppressed by Clonidine in Isolated Rat Vas Deferens.

Pharmacology 2019 29;103(3-4):189-201. Epub 2019 Jan 29.

Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toho University, Funabashi, Japan,

Background: A report examining whether clinically available antidepressants increase urethral smooth muscle contraction via antagonistic effects on the α2-adrenoceptor (α2-AR) is lacking.

Objectives: The present study was performed to evaluate the potential of clinically available antidepressants to reverse α2-AR-mediated contractile inhibition in rat vas deferens, in order to predict whether they can induce voiding impairment.

Method: The effects of 18 antidepressants of different classes on electrical field stimulation (EFS)-induced contractions suppressed by 10-8 mol/L clonidine (a selective α2-AR agonist) in isolated rat vas deferens were investigated and related to their respective clinical blood concentrations. Read More

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http://dx.doi.org/10.1159/000495616DOI Listing
March 2019
1 Read

Impact of Different Pharmacotherapies on Long-Term Outcomes in Patients with Electrical Storm.

Pharmacology 2019 29;103(3-4):179-188. Epub 2019 Jan 29.

First Department of Medicine, University Medical Centre Mannheim (UMM), Faculty of Medicine Mannheim, University of Heidelberg, European Center for AngioScience (ECAS), and DZHK (German Center for Cardiovascular Research) Partner Site Heidelberg/Mannheim, Mannheim, Germany.

Objective: The study sought to assess the long-term prognostic impact of different pharmacotherapies, including angiotensin-converting enzyme inhibitor-inhibitor/angiotensin receptor blocker (ACEi/ARB), statins, and amiodarone in patients with electrical storm (ES).

Background: Data regarding the outcome of patients with ES is limited.

Methods: Consecutive patients with ES from 2002 to 2016 were included. Read More

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http://dx.doi.org/10.1159/000496228DOI Listing
March 2019
4 Reads
1.581 Impact Factor

Osteoprotective Effect of Cimiracemate in Glucocorticoid-Induced Osteoporosis by Osteoprotegerin/Receptor Activator of Nuclear Factor κ B/Receptor Activator of Nuclear Factor Kappa-Β Ligand Signaling.

Pharmacology 2019 29;103(3-4):163-172. Epub 2019 Jan 29.

Department of Orthopedics, Tongren Hosptial, Shanghai Jiao Tong University School of Medicine, Shanghai, China,

Objectives: Present investigation determines the protective effect of cimiracemate A against glucocorticoid-induced osteoporosis rat.

Methods: Osteoporosis was induced by injecting methylprednisolone acetate (21 mg/kg) for the period of 6 weeks, and the rats were treated with cimiracemate A 5 and 10 mg/kg, p.o. Read More

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http://dx.doi.org/10.1159/000495509DOI Listing
March 2019
3 Reads

Anti-Inflammatory Effect of Local Anaesthetic Ropivacaine in Lipopolysaccharide-Stimulated RAW264.7 Macrophages.

Pharmacology 2019 28;103(5-6):228-235. Epub 2019 Jan 28.

Department of the Second Anesthesia, Honghui Hospital, Xi 'an Jiaotong University, Xian, China,

The present manuscript intended to investigate the anti-inflammatory effect of ropivacaine on lipopolysaccharide-induced inflammation in RAW 264.7 macrophages. Results suggested that ropivacaine causes significant inhibition of generation of nitric oxide (NO), prostaglandin E2, tumor necrosis factor (TNF)-α, interleukin (IL)-6, and IL-1β, as well as expression of their synthesizing enzymes, inducible NO synthase, and cyclooxygenase-2. Read More

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http://dx.doi.org/10.1159/000496425DOI Listing
January 2019
1 Read
1.581 Impact Factor

Panax Notoginseng Extract Possesses Significant Antibacterial Activity against Pathogenic Streptococci.

Pharmacology 2019 28;103(5-6):221-227. Epub 2019 Jan 28.

Department of Microbiology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan,

Background: In traditional Chinese medicine, Panax notoginseng is used to treat inflammation and bleeding but has not been shown to affect bacterial pathogens.

Objectives: Our aim was to assess the antibacterial potential of Panax notoginseng extract (PNE) against bacterial pathogens.

Methods: PNE was dissolved in autoclaved distilled water. Read More

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http://dx.doi.org/10.1159/000496830DOI Listing
January 2019
1 Read

Anti-Inflammatory and Hepatoprotective Effects of Ganoderma lucidum Polysaccharides against Carbon Tetrachloride-Induced Liver Injury in Kunming Mice.

Pharmacology 2019 23;103(3-4):143-150. Epub 2019 Jan 23.

School of Food Science, Nanjing Xiaozhuang University, Nanjing, China.

Background: Ganoderma lucidum Polysaccharides (GLPS) were found to possess various pharmacological properties including anti-inflammatory and hepatoprotective activities. However, the effect and possible mechanism of GLPS treatment on liver injury have not yet been reported. Therefore, this study aimed to explore the potential anti-inflammatory and hepatoprotective effects and possible mechanism of GLPS in carbon tetrachloride (CCl4)-induced acute liver injury mice. Read More

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http://dx.doi.org/10.1159/000493896DOI Listing
March 2019
8 Reads
1.581 Impact Factor

Blockade of Serotonin 2C Receptors with SB-242084 Moderates Reduced Locomotor Activity and Rearing by Cannabinoid 1 Receptor Antagonist AM-251.

Pharmacology 2019 23;103(3-4):151-158. Epub 2019 Jan 23.

Department of Pharmacodynamics, Semmelweis University, Budapest, Hungary,

The endocannabinoid and serotonin (5-HT) systems have key roles in the regulation of several physiological functions such as motor activity and food intake but also in the development of psychiatric disorders. Here we tested the hypothesis, whether blockade of serotonin 2C (5-HT2C) receptors prevents the reduced locomotor activity and other behavioral effects caused by a cannabinoid 1 (CB1) receptor antagonist. As a pretreatment, we administered SB-242084 (1 mg/kg, ip. Read More

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http://dx.doi.org/10.1159/000495939DOI Listing
March 2019
3 Reads

Tanshinone IIA Ameliorate Coxsackie Virus B3-Induced Viral Myocarditis through the Inhibition of Inflammation and Modulation T Helper 1/T Helper 2 Balance in Mice.

Pharmacology 2019 2;103(3-4):136-142. Epub 2019 Jan 2.

Department of Pharmacy, The Affiliated Hospital of Qingdao University, Qingdao, China,

To investigate the effect of Tanshinone IIA (TSA) on viral myocarditis (VMC). VMC animal model was established using BALB/c mice by intraperitoneally injecting Coxsackie virus B3 (CVB3). The mice were randomly divided into control group, model group, and TSA group. Read More

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https://www.karger.com/Article/FullText/495755
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http://dx.doi.org/10.1159/000495755DOI Listing
March 2019
13 Reads

In vitro Inhibitory Effects of Isofraxidin on Human Liver Cytochrome P450 Enzymes.

Pharmacology 2019 13;103(3-4):120-127. Epub 2018 Dec 13.

Department of Pharmacy, Yidu Central Hospital of Weifang, Weifang, China,

Isofraxidin is a Coumarin compound widely distributed in plants, such as the Umbelliferae or Chloranthaceae, and it possesses numerous pharmacological activities. However, whether isofraxidin affects the activity of human liver cytochrome P450 (CYP) enzymes remains unclear. In this study, the inhibitory effects of isofraxidin on the 8 human liver CYP isoforms (i. Read More

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http://dx.doi.org/10.1159/000495212DOI Listing
March 2019
2 Reads

Ameliorative Effect of Withaferin A on Ageing-Mediated Impairment in the Dopamine System and Its Associated Behavior of Wistar Albino Rat.

Pharmacology 2019 13;103(3-4):114-119. Epub 2018 Dec 13.

Department of Anatomy, Velammal Medical College and Hospital, Madurai, India,

Withaferin A (WA) was evaluated for its neuro-protective efficacy on ageing induced striatal dopamine (DA) and behavioural changes in aged rats. Wistar albino rats were divided into group I - young (3 months), Group II - aged (24 months), Group III - aged rats supplemented with WA (50 mg/kg b.w once in a day for 30 days) and Group IV - young rats supplemented with WA (50 mg/kg b. Read More

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http://dx.doi.org/10.1159/000495510DOI Listing
March 2019
2 Reads

Effective Ibuprofen Desensitization in a Patient with Myopericarditis.

Pharmacology 2019 13;103(3-4):111-113. Epub 2018 Dec 13.

Internal Medicine, Allergy Unit, Rimini Hospital, Azienda Sanitaria Romagna, Rimini, Italy.

To date, aspirin desensitization is employed with patients with nonsteroidal anti-inflammatory drugs (NSAIDs) exacerbated respiratory diseases (NERD) or with aspirin or NSAIDs hypersensitive patients needing a stent procedure for coronary artery disease. On the other hand, few data exist regarding aspirin desensitization in other cardiological features and particularly we haven't data on different NSAIDs desensitization. Only for NERD patients we have data on ketorolac use. Read More

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https://www.karger.com/Article/FullText/495692
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http://dx.doi.org/10.1159/000495692DOI Listing
March 2019
5 Reads

Expression of Matrix Metalloproteinase-2, Tissue Inhibitor of Matrix Metalloproteinase-2 and CD147 in the Traditional Chinese Medicine "Compound T11" for Treatment of Chronic Liver Injury.

Pharmacology 2019 13;103(3-4):128-135. Epub 2018 Dec 13.

First Clinical Medical School, Henan University of Chinese Medicine, Zhengzhou, China.

Objectives: To measure the expression of matrix metalloproteinase (MMP)-2, tissue inhibitor of matrix metalloproteinase inhibitor (TIMP)-2, and CD147 in mice with chronic liver injury induced by carbon tetrachloride after treatment with the traditional Chinese medicine (TCM) "Compound T11".

Method: Sixty male ICR mice were divided randomly into 6 groups of 10: control (C), model (M), low-dose treatment (LT; 50 mg/mL of Compound T11), medium-dose treatment (MT, 100 mg/mL), high-dose treatment (HT, 150 mg/mL), and positive drug treatment (YT, 67.5 mg/mL). Read More

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http://dx.doi.org/10.1159/000495141DOI Listing
March 2019
2 Reads

Taxifolin Inhibits Receptor Activator of NF-κB Ligand-Induced Osteoclastogenesis of Human Bone Marrow-Derived Macrophages in vitro and Prevents Lipopolysaccharide-Induced Bone Loss in vivo.

Pharmacology 2019 6;103(1-2):101-109. Epub 2018 Dec 6.

Department of Spine Surgery, Xiangya Hospital, Central South University, Changsha, China,

It has been reported that taxifolin inhibit osteoclastogenesis in RAW264.7 cells. In our research, the inhibition effects of taxifolin on the osteoclastogenesis of human bone marrow-derived macrophages (BMMs) induced by receptor activator of NF-κB ligand (RANKL) as well as the protection effects in lipopolysaccharide-induced bone lysis mouse model have been demonstrated. Read More

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https://www.karger.com/Article/FullText/495254
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http://dx.doi.org/10.1159/000495254DOI Listing
March 2019
14 Reads

Tauroursodeoxycholic Acid Ameliorates Lipopolysaccharide-Induced Depression Like Behavior in Mice via the Inhibition of Neuroinflammation and Oxido-Nitrosative Stress.

Pharmacology 2019 5;103(1-2):93-100. Epub 2018 Dec 5.

Department of Invasive Technology, Nantong First People's Hospital, The Second Affiliated Hospital of Nantong University, Nantong, China.

Depression is a mental disease that causes severe economic and social burdens. The mechanism for the onset of depression remains largely unknown. Recently, more and more attention is being given to the role of neuroinflammation and oxidative stress in depression. Read More

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http://dx.doi.org/10.1159/000494139DOI Listing
March 2019
4 Reads

Mechanisms of Etomidate-Mediated Decrease of Spontaneous Spike Activity of Mouse Cerebellar Purkinje Cells in vivo.

Pharmacology 2019 5;103(1-2):82-92. Epub 2018 Dec 5.

Key Laboratory of Cellular Function and Pharmacology of Jilin Province, Yanbian University, Yanji, China,

Etomidate is an imidazole, nonbarbiturate hypnotic agent that is increasingly used in procedural sedation. However, the effects of etomidate on the spontaneous activity of cerebellar Purkinje cells (PCs) in living mouse have not been fully understood. In this study, we investigated the effects of etomidate on the spontaneous simple spike (SS) activity of PCs in urethane-anesthetized mice by cell-attached recording and pharmacological methods. Read More

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http://dx.doi.org/10.1159/000494980DOI Listing
March 2019
5 Reads

Involvement of the cAMP-Dependent Pathway in Dextromethorphan-Induced Inhibition of Spontaneous Glutamate Transmission in the Nucleus Tractus Solitarius Neurons of Guinea Pigs.

Pharmacology 2019 5;103(1-2):76-81. Epub 2018 Dec 5.

Laboratory of Neuropharmacology, School of Pharmacy, Aichi Gakuin University, Nagoya, Japan.

Dextromethorphan (DEX) presynaptically decreases glutamatergic transmission in second-order neurons of the nucleus tractus solitarius (TS). To clarify the inhibitory mechanism of DEX, the present study examined the interaction of DEX with cAMP. The effects of DEX on miniature and TS-evoked excitatory postsynaptic currents (mEPSCs and eEPSCs) were recorded under activation of the cAMP-dependent pathway using the brainstem slices. Read More

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http://dx.doi.org/10.1159/000495295DOI Listing
March 2019
4 Reads

ErbB4 Receptors in the Medial Habenula Regulate Contextual Fear Memory.

Pharmacology 2019 4;103(1-2):68-75. Epub 2018 Dec 4.

Department of Pathophysiology, Zunyi Medical College, Zunyi, China.

The Medial Habenular (MHb) and the Lateral Habenular nuclei are 2 main parts of the habenular complex (Hb). Recent studies showed that MHb plays an important role in memory, and in the expression of ErbB4. However, the expression of MHb ErbB4 receptor and its role in fear memory is not well understood. Read More

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http://dx.doi.org/10.1159/000495064DOI Listing
March 2019
14 Reads

Mechanisms of Hydrogen Sulfide against the Progression of Severe Alzheimer's Disease in Transgenic Mice at Different Ages.

Pharmacology 2019 16;103(1-2):50-60. Epub 2018 Nov 16.

Department of Biomedical, Metabolic and Neural Sciences, Section of Pharmacology and Molecular Medicine, University of Modena and Reggio Emilia, Modena, Italy,

Backgroud: Alzheimer disease is an age-related severe neurodegenerative pathology. The level of the third endogenous gas, hydrogen sulfide (H2S), is decreased in the brain of Alzheimer's disease (AD) patients compared with the brain of the age-matched normal individuals; also, plasma H2S levels are negatively correlated with the severity of AD. Recently, we have demonstrated that systemic H2S injections are neuroprotective in an early phase of preclinical AD. Read More

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http://dx.doi.org/10.1159/000494113DOI Listing
March 2019
15 Reads

Propranolol Suppresses Cobalt Chloride-Induced Hypoxic Proliferation in Human Umbilical Vein Endothelial Cells in vitro.

Pharmacology 2019 16;103(1-2):61-67. Epub 2018 Nov 16.

Department of Dermatology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China,

Background/aims: To investigate the effect of propranolol on cobalt chloride (CoCl2)-induced hypoxic proliferation in human umbilical vein endothelial cells (HUVECs).

Methods: CoCl2 was administrated to HUVECs to mimic hypoxic proliferation in infantile hemangioma. The proliferation of HUVECs was detected by Cell Counting Kit-8. Read More

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https://www.karger.com/Article/FullText/494762
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http://dx.doi.org/10.1159/000494762DOI Listing
March 2019
12 Reads
1.581 Impact Factor

Multiple-Dose Pharmacokinetics, Pharmacodynamics, and Safety of the Urotensin-II Receptor Antagonist Palosuran in Healthy Male Subjects.

Pharmacology 2018 1;102(5-6):339-346. Epub 2018 Nov 1.

Department of Clinical Pharmacology, Actelion Pharmaceuticals Ltd, Allschwil, Switzerland.

Purpose: To investigate the multiple-dose pharmacokinetics (PK), pharmacodynamics (PD), and tolerability of palosuran, a selective, potent antagonist of the human UT receptor.

Methods: This was a double-blind, randomized, placebo-controlled study. Three dose levels were investigated for PKs, PDs, and safety in sequential groups of 8 subjects each. Read More

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https://www.karger.com/Article/FullText/492936
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http://dx.doi.org/10.1159/000492936DOI Listing
December 2018
7 Reads

Tetanic Facilitation of Neuromuscular Transmission by Adenosine A2A and Muscarinic M1 Receptors is Dependent on the Uptake of Choline via High-Affinity Transporters.

Pharmacology 2019 31;103(1-2):38-49. Epub 2018 Oct 31.

Department of Pharmacology and Therapeutic, State University of Maringá, Maringá,

Background/aims: In this study, we evaluated the functional impact of facilitatory presynaptic adenosine A2A and muscarinic M1 receptors in the recovery of neuromuscular tetanic depression caused by the blockage of high-affinity choline transporter (HChT) by hemicholinium-3 (HC-3), a condition that mimics a myasthenia-like condition.

Methods: Rat diaphragm preparations were indirectly stimulated via the phrenic nerve trunk with 50-Hz frequency trains, each consisting of 500-750 supramaximal intensity pulses. The tension at the beginning (A) and at the end (B) of the tetanus was recorded and the ratio (R) B/A calculated. Read More

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https://www.karger.com/Article/FullText/494058
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March 2019
6 Reads

Comparative Pharmacokinetic Study of Mangiferin in Normal and Alloxan-Induced Diabetic Rats after Oral and Intravenous Administration by UPLC-MS/MS.

Pharmacology 2019 25;103(1-2):30-37. Epub 2018 Oct 25.

Laboratory Animal Center, Chongqing Medical University, Chongqing,

Backgrounds: Diabetes mellitus (DM)-induced morphological and/or functional complications may alter the pharmacokinetic profiles of mangiferin. This study aims to compare pharmacokinetic profiles of mangiferin in normal and alloxan-induced diabetic rats after oral and intravenous administration.

Methods: Mangiferin was administered orally (10 mg/kg) and intravenously (2 mg/kg) to normal and alloxan-induced diabetic Sprague-Dawley (SD) rats (n = 8). Read More

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https://www.karger.com/Article/FullText/493364
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March 2019
20 Reads

Malondialdehyde Assay in the Evaluation of Aspirin Antiplatelet Effects.

Pharmacology 2019 24;103(1-2):23-29. Epub 2018 Oct 24.

Institute for Pharmacology and Clinical Pharmacology, Heinrich Heine University, Düsseldorf, Germany.

Aspirin is essential in secondary prevention of patients after myocardial infarction and with coronary artery disease. However, impaired pharmacodynamic response to aspirin is frequent (high on-treatment platelet reactivity [HTPR]). This leads to an enhanced prevalence of cardiovascular events and to an impaired clinical outcome. Read More

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https://www.karger.com/Article/FullText/493754
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March 2019
15 Reads

Prevention of Stent Thrombosis in Rats by a Direct Oral Factor Xa Inhibitor Edoxaban.

Pharmacology 2019 19;103(1-2):17-22. Epub 2018 Oct 19.

Rare Disease Laboratories, Daiichi Sankyo Co., Ltd., Tokyo, Japan.

Background/aims: Stent thrombosis is a serious complication after percutaneous coronary intervention and femoropopliteal endovascular intervention. The aim of this study was to determine the antithrombotic effects of a direct factor Xa inhibitor edoxaban alone or in combination with antiplatelet agents in a rat model of stent thrombosis.

Methods: Stainless steel stents (4 stents per rat) were placed in an extracorporeal arteriovenous shunt. Read More

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https://www.karger.com/Article/FullText/494059
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March 2019
18 Reads

In vitro and in vivo GABAA Receptor Interaction of the Propanidid Metabolite 4-(2-[Diethylamino]-2-Oxoethoxy)-3-Methoxy-Benzeneacetic Acid.

Pharmacology 2019 17;103(1-2):10-16. Epub 2018 Oct 17.

KL Maddy Equine Analytical Chemistry Laboratory, University of California Davis, Davis, California, USA.

Background: Propanidid is a γ-aminobutyric acid type A (GABAA) receptor agonist general anesthetic and its primary metabolite is 4-(2-[diethylamino]-2-oxoethoxy)-3-methoxy-benzeneacetic acid (DOMBA). Despite having a high water solubility at physiologic pH that might predict low-affinity GABAA receptor interactions, DOMBA is reported to have no effect on GABAA receptor currents, possibly because the DOMBA concentrations studied were simply insufficient to modulate GABAA receptors. Our objectives were to measure the propanidid and DOMBA concentration responses on -GABAA receptors and to measure the behavioral responses of DOMBA in mice at concentrations that affect GABAA receptor currents in vitro. Read More

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March 2019
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Involvement of MicroRNA-133a in the Protective Effect of Hydrogen Sulfide against Ischemia/Reperfusion-Induced Endoplasmic Reticulum Stress and Cardiomyocyte Apoptosis.

Pharmacology 2019 16;103(1-2):1-9. Epub 2018 Oct 16.

Department of Cardiology, Bethune International Peace Hospital, Shijiazhuang,

Aim: Myocardial ischemia/reperfusion (I/R) injury is a severe trauma that cells undergo and is associated with cardiomyocyte apoptosis. Recently, miRNAs have been demonstrated to play an important role in cardiovascular biology and disease. However, whether the miR-133a and ER stress play a role in hydrogen sulfide (H2S) protection of cardiomyocytes against I/R-induced apoptosis remains unclear. Read More

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https://www.karger.com/Article/FullText/492969
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March 2019
14 Reads
1.580 Impact Factor

Antiallodynic Effects of Intrathecal Areca Nut for Spinal Nerve-Ligated and Chemotherapy-Induced Neuropathic Pain in Rats.

Pharmacology 2018 10;102(5-6):332-338. Epub 2018 Oct 10.

Department of Anesthesiology and Pain Medicine, Chonnam National University Medical School, Gwangju, Republic of

This study examined the effects of intrathecal areca nut on spinal nerve-ligated and chemotherapy-induced neuropathic pain (NP), and investigated the relevance of spinal 5-hydroxytryptamine (5-HT) and α2-adrenergic receptors to those effects. For drug administration, intrathecal catheters were inserted into the subarachnoid space of male Sprague-Dawley rats. NP was induced either by spinal nerve ligation (left spinal nerves L5 and L6) or by chemotherapeutic injection (intraperitoneal cisplatin, 2 mg/kg/day, once daily for 4 days). Read More

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https://www.karger.com/Article/FullText/492394
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December 2018
5 Reads

Structure-Activity Relationship of the GPR55 Antagonist, CID16020046.

Pharmacology 2018 8;102(5-6):324-331. Epub 2018 Oct 8.

Background/aims: CID16020046 blocks the effect of the lipid lysophosphatidylinositol (LPI) at its receptor, GPR55. CID16020046 and another antagonist, ML193, have been used to investigate GPR55-mediated effects of LPI on cells, tissues, and in vivo. Here we describe the structure-activity relationship of CID16020046. Read More

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https://www.karger.com/Article/FullText/493490
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December 2018
6 Reads

The Anticancer Effect of Huaier Extract in Renal Cancer 786-O Cells.

Pharmacology 2018 8;102(5-6):316-323. Epub 2018 Oct 8.

Department of Urology, Qilu Hospital of Shandong University, Jinan,

Background: Trametes robiniophila Murr (Huaier) has been used as an adjuvant therapy of tumor in traditional Chinese medicine for many years, but the underlying mechanisms are largely unknown. In the present study, we tested the inhibitory effect of Huaier extract on renal cancer 786-O cells and explored the possible mechanisms.

Methods: 786-O cells were treated by gradient concentrations of Huaier extract, cell viability, invasion, migration and apoptosis were assessed by cell counting kit 8, cell scratch, transwell, and flow cytometry assay in vitro. Read More

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https://www.karger.com/Article/FullText/492935
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December 2018
23 Reads

Ropivacaine Protects against Memory Impairment and Hippocampal Damage in a Rat Neurodegeneration Model.

Pharmacology 2018 26;102(5-6):307-315. Epub 2018 Sep 26.

Graduate Institute of Basic Medicine, New Taipei City,

Background: Ropivacaine, a long-acting amide local anesthetic agent, has been demonstrated to inhibit glutamatergic transmission. Glutamate neurotoxicity plays a pivotal role in the pathogenesis of brain disorders. The purpose of this study is to investigate the neuroprotective effect of ropivacaine against brain damage induced by kainic acid (KA), an analogue of glutamate. Read More

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http://dx.doi.org/10.1159/000493145DOI Listing
December 2018
3 Reads

Nitrosonifedipine, a Photodegradation Product of Nifedipine, Suppresses Pharmacologically Induced Aortic Aneurysm Formation.

Pharmacology 2018 25;102(5-6):287-299. Epub 2018 Sep 25.

Department of Pharmacy, Tokushima University Hospital, Tokushima,

Background/aims: We have reported that nitrosonifedipine (NO-NIF), a photodegradation product of nifedipine, has strong antioxidant and endothelial protective effects, and can suppress several cardiovascular diseases in animal models. The objective of the present study was to investigate the effects of NO-NIF on aortic aneurysm formation.

Methods: The mice were infused with β-aminopropionitrile for 2 weeks and angiotensin II for 6 weeks to induce aortic aneurysm formation. Read More

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http://dx.doi.org/10.1159/000492577DOI Listing
December 2018
3 Reads