9,671 results match your criteria Pharmacological Stress Testing


Reviewing the effects of dietary salt on cognition: mechanisms and future directions.

Asia Pac J Clin Nutr 2019 ;28(1):6-14

Department of Pharmacology, School of Medical Sciences, University of New South Wales, Sydney, Australia.

Background And Objectives: Consumption of salt exceeds dietary guidelines for many countries around the world, despite efforts to increase awareness of the potential cardiovascular health risks. Emerging evidence, primarily from rodent models, indicates that high salt intake may also impair aspects of cognitive function. To our knowledge, here we provide the first review of the effects of salt on cognition. Read More

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http://dx.doi.org/10.6133/apjcn.201903_28(1).0002DOI Listing
January 2019

Subsequent Event Risk in Individuals with Established Coronary Heart Disease: Design and Rationale of the GENIUS-CHD Consortium.

Authors:
Riyaz Patel Vinicius Tragante Amand F Schmidt Raymond O McCubrey Michael V Holmes Laurence J Howe Kenan Direk Axel Åkerblom Karin Leander Salim S Virani Karol A Kaminski Jochen D Muehlschlegel Hooman Allayee Peter Almgren Maris Alver Ekaterina V Baranova Hassan Behlouli Bram Boeckx Peter S Braund Lutz P Breitling Graciela Delgado Nubia E Duarte Marie-Pierre Dubé Line Dufresne Niclas Eriksson Luisa Foco Markus Scholz Crystel M Gijsberts Charlotte Glinge Yan Gong Jaana Hartiala Mahyar Heydarpour Jaroslav A Hubacek Marcus Kleber Daniel Kofink Salma Kotti Pekka Kuukasjärvi Vei-Vei Lee Andreas Leiherer Petra A Lenzini Daniel Levin Leo-Pekka Lyytikäinen Nicola Martinelli Ute Mons Christopher P Nelson Kjell Nikus Anna P Pilbrow Rafal Ploski Yan V Sun Michael W T Tanck W H Wilson Tang Stella Trompet Sander W van der Laan Jessica Van Setten Ragnar O Vilmundarson Chiara Viviani Anselmi Efthymia Vlachopoulou Lawien Al Ali Eric Boerwinkle Carlo Briguori John F Carlquist Kathryn F Carruthers Gavino Casu John Deanfield Panos Deloukas Frank Dudbridge Thomas Engström Natalie Fitzpatrick Kim Fox Bruna Gigante Stefan James Marja-Liisa Lokki Paulo A Lotufo Nicola Marziliano Ify R Mordi Joseph B Muhlestein Christopher Newton-Cheh Jan Pitha Christoph H Saely Ayman Samman-Tahhan Pratik B Sandesara Andrej Teren Adam Timmis Frans Van de Werf Els Wauters Arthur A M Wilde Ian Ford David J Stott Ale Algra Maria G Andreassi Diego Ardissino Benoit J Arsenault Christie M Ballantyne Thomas O Bergmeijer Connie R Bezzina Simon C Body Eric H Boersma Peter Bogaty Michiel Bots Hermann Brenner Jasper J Brugts Ralph Burkhardt Clara Carpeggiani Gianluigi Condorelli Rhonda M Cooper-DeHoff Sharon Cresci Nicolas Danchin Ulf de Faire Robert N Doughty Heinz Drexel James C Engert Keith A A Fox Domenico Girelli Diederick E Grobbee Emil Hagström Stanley L Hazen Claes Held Harry Hemingway Imo E Hoefer G Kees Hovingh Reza Jabbari Julie A Johnson J Wouter Jukema Marcin P Kaczor Mika Kähönen Jiri Kettner Marek Kiliszek Olaf H Klungel Bo Lagerqvist Diether Lambrechts Jari O Laurikka Terho Lehtimäki Daniel Lindholm B K Mahmoodi Anke H Maitland-van der Zee Ruth McPherson Olle Melander Andres Metspalu Anna Niemcunowicz-Janica Oliviero Olivieri Grzegorz Opolski Colin N Palmer Gerard Pasterkamp Carl J Pepine Alexandre C Pereira Louise Pilote Arshed A Quyyumi A Mark Richards Marek Sanak Agneta Siegbahn Tabassome Simon Juha Sinisalo J Gustav Smith John A Spertus Steen Stender Alexandre F R Stewart Wojciech Szczeklik Anna Szpakowicz Jean-Claude Tardif Jurriën M Ten Berg Jacob Tfelt-Hansen George Thanassoulis Joachim Thiery Christian Torp-Pedersen Yolanda van der Graaf Frank L J Visseren Johannes Waltenberger Peter E Weeke Pim Van der Harst Chim C Lang Naveed Sattar Vicky A Cameron Jeffrey L Anderson James M Brophy Guillaume Paré Benjamin D Horne Winfried März Lars Wallentin Nilesh J Samani Aroon D Hingorani Folkert W Asselbergs

Circ Genom Precis Med 2019 Mar 21. Epub 2019 Mar 21.

Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht, Netherlands.

Background: The "GENetIcs of sUbSequent Coronary Heart Disease" (GENIUS-CHD) consortium was established to facilitate discovery and validation of genetic variants and biomarkers for risk of subsequent CHD events, in individuals with established CHD.

Methods: The consortium currently includes 57 studies from 18 countries, recruiting 185,614 participants with either acute coronary syndrome, stable CHD or a mixture of both at baseline. All studies collected biological samples and followed-up study participants prospectively for subsequent events. Read More

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http://dx.doi.org/10.1161/CIRCGEN.119.002470DOI Listing

Multigenerational obesity-induced perturbations in oocyte-secreted factor signalling can be ameliorated by exercise and nicotinamide mononucleotide.

Hum Reprod Open 2018 29;2018(3):hoy010. Epub 2018 May 29.

School of Women's and Children's Health, Fertility and Research Centre, University of New South Wales, Sydney, New South Wales 2052, Australia.

Study Question: Can maternal and offspring high-fat diet (HFD)-induced changes in mRNA expression levels in mice be ameliorated by interventions in female offspring?

Summary Answer: Our results indicate that exercise and nicotinamide mononucleotide (NMN) can ameliorate the negative effects of maternal and post-weaning HFD in female offspring.

What Is Known Already: Maternal and post-weaning HFD can perturb offspring developmental trajectories. As rates of maternal obesity are rising globally, there is a need for effective treatments in offspring to ameliorate the negative effects from a maternal obesogenic environment. Read More

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http://dx.doi.org/10.1093/hropen/hoy010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276682PMC

Health Benefits of Anti-aging Drugs.

Subcell Biochem 2019 ;91:339-392

Biochemistry and Biotechnology Department, Vasyl Stefanyk Precarpathian National University, Ivano-Frankivsk, Ukraine.

Aging, as a physiological process mediated by numerous regulatory pathways and transcription factors, is manifested by continuous progressive functional decline and increasing risk of chronic diseases. There is an increasing interest to identify pharmacological agents for treatment and prevention of age-related disease in humans. Animal models play an important role in identification and testing of anti-aging compounds; this step is crucial before the drug will enter human clinical trial or will be introduced to human medicine. Read More

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http://dx.doi.org/10.1007/978-981-13-3681-2_13DOI Listing
January 2019

Effectiveness and cost-effectiveness of the modified Pilates method versus aerobic exercise in the treatment of patients with fibromyalgia: protocol for a randomized controlled trial.

BMC Rheumatol 2019 18;3. Epub 2019 Jan 18.

1Master's and Doctoral Program in Physical Therapy, Universidade Cidade de São Paulo, Rua Cesário Galeno 475, São Paulo SP, CEP: 03071-000 Brazil.

Background: Fibromyalgia is characterized by chronic generalized pain, fatigue, sleep disorders and other symptoms. Physical exercise is recommended as the first choice of non-pharmacological therapy. Thus, the aim of this study is to evaluate the effectiveness and cost-effectiveness of modified Pilates exercises compared to aerobic exercises in the treatment of patients with fibromyalgia. Read More

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http://dx.doi.org/10.1186/s41927-018-0051-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390629PMC
January 2019

Reduced Apoptosis in Chinese Hamster Ovary Cells via Optimized CRISPR Interference.

Biotechnol Bioeng 2019 Mar 18. Epub 2019 Mar 18.

The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Denmark.

Chinese hamster ovary (CHO) cells are widely used for biopharmaceutical protein production. One challenge limiting CHO cell productivity is apoptosis stemming from cellular stress during protein production. Here we applied CRISPR interference (CRISPRi) to downregulate the endogenous expression of apoptotic genes Bak, Bax, and Casp3 in CHO cells. Read More

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http://dx.doi.org/10.1002/bit.26969DOI Listing
March 2019
4.126 Impact Factor

High-Sensitivity Cardiac Troponin After Cardiac Stress Test: A Systematic Review and Meta-Analysis.

J Am Heart Assoc 2019 Mar;8(6):e008626

1 Department of Anesthesiology Washington University School of Medicine in St. Louis MO.

Background The recent introduction of high-sensitivity cardiac troponin (hs-cTn) assays has allowed clinicians to measure hs-cTn before and after cardiac stress testing, but the hs-cTn release pattern and potential utility in identifying inducible myocardial ischemia are unclear. We thus conducted a systematic review and meta-analysis to improve our understanding of hs-cTn release associated with exercise and pharmacological stress testing. Methods and Results Studies published between January 2008 and July 2016 that reported hs-cTn change values (high-sensitivity cardiac troponin T [hs-cTnT] or high-sensitivity cardiac troponin I [hs-cTnI]) in relation to cardiac stress testing were searched and reviewed by 2 independent screeners. Read More

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http://dx.doi.org/10.1161/JAHA.118.008626DOI Listing
March 2019
1 Read

A Thermogenic-Like Brown Adipose Tissue Phenotype is Dispensable for Enhanced Glucose Tolerance in Female Mice.

Diabetes 2019 Mar 12. Epub 2019 Mar 12.

Nutrition and Exercise Physiology, University of Missouri, Columbia, MO, USA

The prevailing dogma is that thermogenic brown adipose tissue (BAT) contributes to improvements in glucose homeostasis in obesogenic animal models; though, much of the evidence supporting this premise is from thermostressed rodents. Whether modulation of the BAT morphology/function drives changes in glucoregulation at thermoneutrality requires further investigation. We utilized loss and gain-of-function approaches including genetic manipulation of the lipolytic enzyme , change in environmental temperature, and lifestyle interventions to comprehensively test the premise that a thermogenic-like BAT phenotype is coupled with enhanced glucose tolerance in female mice. Read More

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http://dx.doi.org/10.2337/db18-1070DOI Listing
March 2019
2 Reads

Toxicological evaluation of Picralima nitida in rodents.

J Ethnopharmacol 2019 Mar 7;236:205-219. Epub 2019 Mar 7.

Traditional Medicine Officer, West African Health Organization (WAHO), Burkina Faso. Electronic address:

Picralima nitida (Stapf) T. Durand and H. Durand (Apocynaceae), over the years has shown wide range of usage in African folk medicine and its safety profile in instances of prolonged use and pregnancy are major concerns. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03788741183398
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http://dx.doi.org/10.1016/j.jep.2019.03.008DOI Listing
March 2019
4 Reads

Biosynthesis of isocitric acid in repeated-batch culture and testing of its stress-protective activity.

Appl Microbiol Biotechnol 2019 Mar 9. Epub 2019 Mar 9.

Department of Higher Nervous Activity, Faculty of Biology, Lomonosov Moscow State University, 1-12 Leninskie Gory, Moscow, 119234, Russia.

Biosynthesis of Ds(+)-threo-isocitric acid from ethanol in the Yarrowia lipolytica batch and repeated-batch cultures was studied. Repeated-batch cultivation was found to provide for a good biosynthetic efficiency of the producer for as long as 748 h, probably due to maintenance of high activities of enzymes involved in the biosynthesis of isocitric acid. Under optimal repeated-batch cultivation conditions, the producer accumulated 109. Read More

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http://dx.doi.org/10.1007/s00253-019-09729-8DOI Listing

Physical and cognitive training are able to prevent recognition memory deficits related to amyloid beta neurotoxicity.

Behav Brain Res 2019 Mar 4;365:190-197. Epub 2019 Mar 4.

Physiology Research Group, Federal University of Pampa, Multicentric Graduate Program in Physiological Sciences - SBFis/Unipampa, Uruguaiana, RS, Brazil. Electronic address:

Alzheimer's disease (AD) is characterized by the presence of amyloid-β (Aβ), oxidative damage and neuronal degeneration, which, together with other pathological events, promote progressive memory loss and cognitive decline. Non-pharmacological strategies have been study to provide some protection against the development of AD. Considering that physical exercise neuroprotective effects on prevention of cognitive deficits are well elucidate, it is important clarify the effects of cognitive training, and verify if they are similar or comparable to those observed for physical exercise. Read More

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http://dx.doi.org/10.1016/j.bbr.2019.03.007DOI Listing
March 2019
1 Read

Changes in left ventricular repolarization after short-term testosterone replacement therapy in hypogonadal males.

J Endocrinol Invest 2019 Mar 5. Epub 2019 Mar 5.

Department of Experimental and Clinical Medicine, University of Catanzaro  « Magna Grecia », Catanzaro, Italy.

Background And Aim: Evidences suggest that androgen deficiency is associated with sudden cardiac death (SCD). Our purpose was to analyse some electrocardiographic (ECG) markers of repolarization phase in hypogonadal patients either at baseline or after testosterone replacement therapy (TRT).

Patients And Methods: Baseline and after 6 months of testosterone replacement therapy, 14 hypogonadal patients and 10 age-matched controls underwent a short-term ECG recordings at rest and immediately after a maximal exercise test. Read More

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http://dx.doi.org/10.1007/s40618-019-01026-5DOI Listing
March 2019
2 Reads

Beta -adrenergic ligand racemic formoterol exhibits enantioselective disposition in blood and skeletal muscle of humans, and elicits myocellular protein kinase A-signalling at therapeutic inhaled doses.

Drug Test Anal 2019 Mar 5. Epub 2019 Mar 5.

Discipline of Pharmacy, School of Medicine, University of Tasmania, Hobart, Australia.

While studies have demonstrated substantial differences in beta -adrenergic agonist enantiomer pharmacology, enantioselective disposition of long-acting beta -adrenergic ligand racemic (rac)-formoterol in blood is unexplored after inhaled therapy given analytical challenges. Furthermore, information on enantioselective disposition and partitioning of beta -adrenergic agonist in skeletal muscle is absent despite its promising data on muscle anabolism in humans. Using a sensitive UPLC-MS/MS (ultra-high performance liquid chromatography-mass spectrometry) assay, we determined disposition of (R,R)-formoterol and (S,S)-formoterol in plasma and skeletal muscle samples from 11 non-asthmatic men who had inhaled rac-formoterol at therapeutic doses (2×27 μg). Read More

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http://dx.doi.org/10.1002/dta.2580DOI Listing
March 2019
2 Reads

No evidence that wheel-running exercise impacts cocaine conditioned place preference in male C57BL/6J mice.

Behav Brain Res 2019 Mar 2;365:110-113. Epub 2019 Mar 2.

Department of Psychology, University of Liège, Belgium.

Wheel-running in rodents can mitigate addiction-related effects of drugs of abuse like cocaine. However, conditioned place preference (CPP) experiments have reported conflicting results, a situation warranting further studies. Our purpose was to test whether wheel-running exercise during adolescence could impact the formation and long-term retention of CPP to cocaine in mice. Read More

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http://dx.doi.org/10.1016/j.bbr.2019.03.002DOI Listing

Preoperative Cardiac Stress Tests Ordered in the Preoperative Evaluation Clinic: A Retrospective Review of Ordering Patterns.

Cardiol Res 2019 Feb 24;10(1):1-8. Epub 2019 Feb 24.

Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital/Harvard Medical School, 75 Francis Street, CWN-L1, Boston, MA 02115, USA.

Background: The role of anesthesiologists has expanded from operating rooms to preoperative evaluation clinics. This role involves performing preoperative cardiovascular evaluation and optimization of patients before elective surgery, which can include ordering cardiac stress tests. We aimed to study the ordering patterns by anesthesiologists for preoperative cardiac stress tests, focusing on whether societal and institutional guidelines and recommendations were used. Read More

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http://dx.doi.org/10.14740/cr821DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396798PMC
February 2019

Rationale and Current Evidence for Testing Iron Chelators for Treating Stroke.

Curr Cardiol Rep 2019 Mar 4;21(4):20. Epub 2019 Mar 4.

Beth Israel Deaconess Medical Center, Department of Neurology, Division of Stroke & Cerebrovascular Disease, Harvard Medical School, 330 Brookline Avenue - Palmer 127, Boston, MA, 02215, USA.

Purpose Of Review: To discuss the mechanisms of iron regulation in the brain and the pathophysiological role of deregulation of iron homeostasis following a stroke, and to review existing evidence supporting the potential role of iron chelators in the treatment of ischemic and hemorrhagic stroke.

Recent Findings: In recent years, accumulating evidence has highlighted the role of neuroinflammation in neurological injury after ischemic and hemorrhagic stroke, and that free iron is central to this process. Via the Fenton reaction, free iron catalyzes the conversion of superoxide ion and hydrogen peroxide into hydroxyl radicals, which promote oxidative stress. Read More

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http://dx.doi.org/10.1007/s11886-019-1106-zDOI Listing
March 2019
1 Read

[Change of short-chain acyl-CoA dehydrogenase in heart failure after myocardial infarction in rats and the intervention of aerobic exercise].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2019 Feb;31(2):172-177

Department of Clinical Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, Guangdong, China.

Objective: To Study the changes of short-chain acyl-CoA dehydrogenase (SCAD) in heart failure (HF) after myocardial infarction (MI), and the effect of aerobic exercise on SCAD.

Methods: Healthy male Sprague-Dawley (SD) rats were divided into sham operation group (Sham group), sham operation swimming group (Sham+swim group), HF model group (LAD group) and HF swimming group (LAD+swim group) by random number table method, with 9 rats in each group. The left anterior descending branch of coronary artery (LAD) was ligated to establish a rat model of HF after MI. Read More

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http://dx.doi.org/10.3760/cma.j.issn.2095-4352.2019.02.010DOI Listing
February 2019

The influence of hERG1a and hERG1b isoforms on drug safety screening in iPSC-CMs.

Prog Biophys Mol Biol 2019 Feb 27. Epub 2019 Feb 27.

Department of Medical Physiology, Division Heart & Lungs, University Medical Center Utrecht, the Netherlands. Electronic address:

The human Ether-à-go-go Related Gene (hERG) encodes the pore forming subunit of the channel that conducts the rapid delayed rectifier potassium current I. I drives repolarization in the heart and when I is dysfunctional, cardiac repolarization delays, the QT interval on the electrocardiogram (ECG) prolongs and the risk of developing lethal arrhythmias such as Torsade de Pointes (TdP) increases. TdP risk is incorporated in drug safety screening for cardiotoxicity where hERG is the main target since the I channels appear highly sensitive to blockage. Read More

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http://dx.doi.org/10.1016/j.pbiomolbio.2019.02.003DOI Listing
February 2019
2 Reads

Precision medicine in pantothenate kinase-associated neurodegeneration.

Neural Regen Res 2019 Jul;14(7):1177-1185

Centro Andaluz de Biología del Desarrollo (CABD-CSIC-Universidad Pablo de Olavide), and Centro de Investigación Biomédica en Red: Enfermedades Raras, Instituto de Salud Carlos III, Sevilla, Spain.

Neurodegeneration with brain iron accumulation is a broad term that describes a heterogeneous group of progressive and invalidating neurologic disorders in which iron deposits in certain brain areas, mainly the basal ganglia. The predominant clinical symptoms include spasticity, progressive dystonia, Parkinson's disease-like symptoms, neuropsychiatric alterations, and retinal degeneration. Among the neurodegeneration with brain iron accumulation disorders, the most frequent subtype is pantothenate kinase-associated neurodegeneration (PKAN) caused by defects in the gene encoding the enzyme pantothenate kinase 2 (PANK2) which catalyzed the first reaction of the coenzyme A biosynthesis pathway. Read More

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http://dx.doi.org/10.4103/1673-5374.251203DOI Listing
July 2019
6 Reads

Methyl B12 protects PC12 cells against cytotoxicity induced by Aβ.

J Cell Biochem 2019 Feb 21. Epub 2019 Feb 21.

Institute of Pharmacology and Toxicology, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, China.

Alzheimer's disease (AD) is the most common aging-associated dementia. The population of AD patients is increasing as the world age grows. Currently, there is no cure for AD. Read More

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http://dx.doi.org/10.1002/jcb.28475DOI Listing
February 2019
1 Read

Differential effect of regadenoson versus dipyridamole on heart rate in patients with left bundle branch block: How does it affect the results of pharmacological nuclear stress testing?

JRSM Cardiovasc Dis 2019 Jan-Dec;8:2048004019828257. Epub 2019 Feb 10.

Department of Cardiology, Ascension Providence Hospital, Southfield, MI, USA.

Background: Myocardial perfusion imaging (MPI) stress test is performed either using exercise as a stress modality or through the use of pharmacological vasodilator agents in those who cannot exercise. Regadenoson and dipyridamole are some of the most common vasodilator agents used. We aim to study the effect of these agents on the heart rate and the imaging results. Read More

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http://journals.sagepub.com/doi/10.1177/2048004019828257
Publisher Site
http://dx.doi.org/10.1177/2048004019828257DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376496PMC
February 2019
2 Reads

The Impact of Hippocampal Sex Hormones Receptors in Modulation of Depressive-Like Behavior Following Chronic Anabolic Androgenic Steroids and Exercise Protocols in Rats.

Front Behav Neurosci 2019 7;13:19. Epub 2019 Feb 7.

Department of Physiology, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia.

The aim of this study was to evaluate alterations in depressive-like behaviors in rats following chronic administration of a supraphysiological dose of anabolic androgenic steroids (AASs) as well as exposure to a prolonged exercise protocol. The role of hippocampal sex hormones receptors in the modulation of depressive-like behavior was also assessed. A total of 48 male Wistar albino rats were divided into six groups: control, exercise (1 h/day, five consecutive days), nandrolone-decanoate (ND, 20 mg/kg/week, in a single dose), exercise plus ND, testosterone-enanthate (TE, 20 mg/kg/week, in a single dose), and exercise plus TE. Read More

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http://dx.doi.org/10.3389/fnbeh.2019.00019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374347PMC
February 2019
2 Reads

p16Ink4a Prevents the Activation of Aged Quiescent Dentate Gyrus Stem Cells by Physical Exercise.

Front Cell Neurosci 2019 7;13:10. Epub 2019 Feb 7.

Institute of Cell Biology and Neurobiology, National Research Council, Foundation Santa Lucia, Rome, Italy.

In the neurogenic niches-the dentate gyrus of the hippocampus and the subventricular zone (SVZ) adjacent to lateral ventricles-stem cells continue to divide during adulthood, generating progenitor cells and new neurons, and to self-renew, thus maintaining the stem cell pool. During aging, the numbers of stem/progenitor cells in the neurogenic niches are reduced. The preservation of the neurogenic pool is committed to a number of antiproliferative genes, with the role of maintaining the quiescence of neural cells. Read More

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http://dx.doi.org/10.3389/fncel.2019.00010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374340PMC
February 2019

Ba-Duan-Jin alleviates pain and fibromyalgia-related symptoms in patients with fibromyalgia: results of a randomised controlled trial.

Clin Exp Rheumatol 2019 Feb 15. Epub 2019 Feb 15.

Department of Rheumatology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.

Objectives: Fibromyalgia is a chronic debilitating pain syndrome. There has been growing interest in the development of non-pharmacological therapies. Ba-Duan-Jin is an ancient Chinese exercise for health promotion, yet easy to learn. Read More

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February 2019
3 Reads
2.724 Impact Factor

The acute effects of caffeine intake on time under tension and power generated during the bench press movement.

J Int Soc Sports Nutr 2019 Feb 18;16(1). Epub 2019 Feb 18.

Department of Sports Training, Jerzy Kukuczka Academy of Physical Education, Katowice, Poland.

Background: The ability to generate high levels of power is one of the key factors determining success in many sport disciplines. Although there are studies confirming ergogenic effects of caffeine (CAF) on different physical and mental abilities, much controversy remains about its influence on power. The main goal of this study was to assess the effects of caffeine supplementation on time under tension (TUT) and the number of performed repetitions (REP). Read More

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http://dx.doi.org/10.1186/s12970-019-0275-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379960PMC
February 2019
1 Read

Self-reported adherence to physical activity recommendations compared to the IPAQ interview in patients with hypertension.

Patient Prefer Adherence 2019 23;13:209-214. Epub 2019 Jan 23.

Postgraduate Studies Program in Cardiology, School of Medicine, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil,

Background: Physical activity (PA) is recommended as adjuvant therapy to control blood pressure (BP). The effectiveness of simple recommendations is not clear. We aimed to assess the agreement between self-report of adherence to PA in clinical routine and International Physical Activity Questionnaire (IPAQ) interview and its association with BP control. Read More

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http://dx.doi.org/10.2147/PPA.S185519DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350830PMC
January 2019
1 Read

Exercise testing oversights underlie missed and delayed diagnosis of catecholaminergic polymorphic ventricular tachycardia in young sudden cardiac arrest survivors.

Heart Rhythm 2019 Feb 11. Epub 2019 Feb 11.

Division of Heart Rhythm Services, Department of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota; Division of Pediatric Cardiology, Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, Minnesota; Windland Smith Rice Sudden Death Genomics Laboratory, Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota. Electronic address:

Background: Catecholaminergic polymorphic ventricular tachycardia (CPVT) is characterized by adrenergically induced ventricular tachycardia, syncope, and sudden cardiac arrest (SCA). In the absence of structural disease, exercise-provoked premature ventricular contractions in bigeminy or couplets and nonsustained ventricular tachycardia are highly predictive of CPVT.

Objective: The purpose of this study was to determine the number of missed or delayed CPVT diagnoses attributable to exercise testing oversights in a cohort of young SCA survivors. Read More

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http://dx.doi.org/10.1016/j.hrthm.2019.02.012DOI Listing
February 2019
2 Reads

TIGAR regulates mitochondrial functions through SIRT1-PGC1α pathway and translocation of TIGAR into mitochondria in skeletal muscle.

FASEB J 2019 Feb 6:fj201802209R. Epub 2019 Feb 6.

Department of Pharmacology and Laboratory of Aging and Nervous Diseases, Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases, School of Pharmaceutical Sciences, Soochow University, Suzhou, China.

TP53-induced glycolysis and apoptosis regulator (TIGAR), a glycolytic inhibitor, plays vital roles in regulating cellular metabolism and oxidative stress. However, the role of highly expressed TIGAR in skeletal muscle remains unexplored. In the present study, TIGAR levels varied in different skeletal muscles and fibers. Read More

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http://dx.doi.org/10.1096/fj.201802209RDOI Listing
February 2019
6 Reads
5.043 Impact Factor

Exercise and resveratrol increase fracture resistance in the 3xTg-AD mouse model of Alzheimer's disease.

BMC Complement Altern Med 2019 Feb 4;19(1):39. Epub 2019 Feb 4.

Department of Anatomy, Arizona College of Osteopathic Medicine, Midwestern University, Glendale, AZ, USA.

Background: Alzheimer's disease (AD) and osteoporosis are progressive diseases that affect the elderly population. Both conditions are associated with fracture risk that is greater than twice that of the healthy population. Resveratrol and exercise are two treatments that have been linked with attenuation of age-related diseases, including the risk of bone fractures. Read More

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http://dx.doi.org/10.1186/s12906-019-2451-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360737PMC
February 2019
3 Reads

Fat Oxidation Rate as a Function of Plasma Lipid and Hormone Response in Endurance Athletes.

J Strength Cond Res 2019 Jan 30. Epub 2019 Jan 30.

Pharmacology and Physiology Department School of Medicine, University of Zaragoza, Zaragoza, Spain.

Soria, M, Ansón, M, Lou-Bonafonte, JM, Andrés-Otero, MJ, Puente, JJ, and Escanero, J. Fat oxidation rate as a function of plasma lipid and hormone response in endurance athletes. J Strength Cond Res XX(X): 000-000, 2019-Plasma lipid changes during incremental exercise are not well known. Read More

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http://dx.doi.org/10.1519/JSC.0000000000003034DOI Listing
January 2019

Protocol for a multicentre randomised controlled parallel-group trial to compare the effectiveness of remotely delivered cognitive-behavioural and graded exercise interventions with usual care alone to lessen the impact of fatigue in inflammatory rheumatic diseases (LIFT).

BMJ Open 2019 Jan 30;9(1):e026793. Epub 2019 Jan 30.

Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, UK.

Introduction: Fatigue remains pervasive, disabling and challenging to manage across all inflammatory rheumatic diseases (IRDs). Non-pharmacological interventions, specifically cognitive-behavioural approaches (CBAs) and graded exercise programmes designed to support and increase exercise, are valuable treatments which help patients with IRD to manage their fatigue. Yet, healthcare systems have encountered substantial barriers to the implementation of these therapeutic options. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-026793DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359876PMC
January 2019
1 Read

Multi-Ancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions.

Authors:
Paul S de Vries Michael R Brown Amy R Bentley Yun J Sung Thomas W Winkler Ioanna Ntalla Karen Schwander Aldi T Kraja Xiuqing Guo Nora Franceschini Ching-Yu Cheng Xueling Sim Dina Vojinovic Jennifer E Huffman Solomon K Musani Changwei Li Mary F Feitosa Melissa A Richard Raymond Noordam Hugues Aschard Traci M Bartz Lawrence F Bielak Xuan Deng Rajkumar Dorajoo Kurt K Lohman Alisa K Manning Tuomo Rankinen Albert V Smith Salman M Tajuddin Evangelos Evangelou Mariaelisa Graff Maris Alver Mathilde Boissel Jin Fang Chai Xu Chen Jasmin Divers Ilaria Gandin Chuan Gao Anuj Goel Yanick Hagemeijer Sarah E Harris Fernando P Hartwig Meian He Andrea R V R Horimoto Fang-Chi Hsu Anne U Jackson Anuradhani Kasturiratne Pirjo Komulainen Brigitte Kühnel Federica Laguzzi Joseph H Lee Jian'an Luan Leo-Pekka Lyytikäinen Nana Matoba Ilja M Nolte Maik Pietzner Muhammad Riaz M Abdullah Said Robert A Scott Tamar Sofer Alena Stancáková Fumihiko Takeuchi Bamidele O Tayo Peter J van der Most Tibor V Varga Yajuan Wang Erin B Ware Wanqing Wen Lisa R Yanek Weihua Zhang Jing Hua Zhao Saima Afaq Najaf Amin Marzyeh Amini Dan E Arking Tin Aung Christie Ballantyne Eric Boerwinkle Ulrich Broeckel Archie Campbell Mickaël Canouil Sabanayagam Charumathi Yii-Der Ida Chen John M Connell Ulf de Faire Lisa de Las Fuentes Renée de Mutsert H Janaka de Silva Jingzhong Ding Anna F Dominiczak Qing Duan Charles B Eaton Ruben N Eppinga Jessica D Faul Virginia Fisher Terrence Forrester Oscar H Franco Yechiel Friedlander Mohsen Ghanbari Franco Giulianini Hans J Grabe Megan L Grove C Charles Gu Tamara B Harris Sami Heikkinen Chew-Kiat Heng Makoto Hirata James E Hixson Barbara V Howard M Arfan Ikram David R Jacobs Craig Johnson Jost Bruno Jonas Candace M Kammerer Tomohiro Katsuya Chiea Chuen Khor Tuomas O Kilpeläinen Woon-Puay Koh Heikki A Koistinen Ivana Kolcic Charles Kooperberg Jose E Krieger Steve B Kritchevsky Michiaki Kubo Johanna Kuusisto Timo A Lakka Carl D Langefeld Claudia Langenberg Lenore J Launer Benjamin Lehne Rozenn N Lemaitre Yize Li Jingjing Liang Jianjun Liu Kiang Liu Marie Loh Tin Louie Reedik Mägi Ani W Manichaikul Colin A McKenzie Thomas Meitinger Andres Metspalu Yuri Milaneschi Lili Milani Karen L Mohlke Thomas H Mosley Kenneth J Mukamal Mike A Nalls Matthias Nauck Christopher P Nelson Nona Sotoodehnia Jeff R O'Connell Nicholette D Palmer Raha Pazoki Nancy L Pedersen Annette Peters Patricia A Peyser Ozren Polasek Neil Poulter Leslie J Raffel Olli T Raitakari Alex P Reiner Treva K Rice Stephen S Rich Antonietta Robino Jennifer G Robinson Lynda M Rose Igor Rudan Carsten O Schmidt Pamela J Schreiner William R Scott Peter Sever Yuan Shi Stephen Sidney Mario Sims Blair H Smith Jennifer A Smith Harold Snieder John M Starr Konstantin Strauch Nicholas Tan Kent D Taylor Yik Ying Teo Yih Chung Tham André G Uitterlinden Diana van Heemst Dragana Vuckovic Melanie Waldenberger Lihua Wang Yujie Wang Zhe Wang Wen Bin Wei Christine Williams Gregory Wilson Mary K Wojczynski Jie Yao Bing Yu Caizheng Yu Jian-Min Yuan Wei Zhao Alan B Zonderman Diane M Becker Michael Boehnke Donald W Bowden John C Chambers Ian J Deary Tõnu Esko Martin Farrall Paul W Franks Barry I Freedman Philippe Froguel Paolo Gasparini Christian Gieger Bernardo L Horta Yoichiro Kamatani Norihiro Kato Jaspal S Kooner Markku Laakso Karin Leander Terho Lehtimäki Patrik K E Magnusson Brenda Penninx Alexandre C Pereira Rainer Rauramaa Nilesh J Samani James Scott Xiao-Ou Shu Pim van der Harst Lynne E Wagenknecht Ya Xing Wang Nicholas J Wareham Hugh Watkins David R Weir Ananda R Wickremasinghe Wei Zheng Paul Elliott Kari E North Claude Bouchard Michele K Evans Vilmundur Gudnason Ching-Ti Liu Yongmei Liu Bruce M Psaty Paul M Ridker Rob M van Dam Sharon L R Kardia Xiaofeng Zhu Charles N Rotimi Dennis O Mook-Kanamori Myriam Fornage Tanika N Kelly Ervin R Fox Caroline Hayward Cornelia M van Duijn E Shyong Tai Tien Yin Wong Jingmin Liu Jerome I Rotter W James Gauderman Michael A Province Patricia B Munroe Kenneth Rice Daniel I Chasman L Adrienne Cupples Dabeeru C Rao Alanna C Morrison

Am J Epidemiol 2019 Jan 29. Epub 2019 Jan 29.

Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, Texas.

An individual's lipid profile is influenced by genetic variants and alcohol consumption, but the contribution of interactions between these exposures has not been studied. We therefore incorporated gene-alcohol interactions into a multi-ancestry genome-wide association study of levels of high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and triglycerides. We included 45 studies in Stage 1 (genome-wide discovery) and 66 studies in Stage 2 (focused follow-up), for a total of 394,584 individuals from five ancestry groups. Read More

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https://academic.oup.com/aje/advance-article/doi/10.1093/aje
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http://dx.doi.org/10.1093/aje/kwz005DOI Listing
January 2019
12 Reads
5.230 Impact Factor

Experimental validation of the 3-parameter critical power model in cycling.

Eur J Appl Physiol 2019 Apr 29;119(4):941-949. Epub 2019 Jan 29.

Department of Molecular and Translational Medicine, University of Brescia, Viale Europa 11, 25123, Brescia, Italy.

Purpose: The three-parameter model of critical power (3-p) implies that in the severe exercise intensity domain time to exhaustion (T) decreases hyperbolically with power output starting from the power asymptote (critical power, ẇ) and reaching 0 s at a finite power limit (ẇ) thanks to a negative time asymptote (k). We aimed to validate 3-p for short T and to test the hypothesis that ẇ represents the maximal instantaneous muscular power.

Methods: Ten subjects performed an incremental test and nine constant-power trials to exhaustion on an electronically braked cycle ergometer. Read More

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http://dx.doi.org/10.1007/s00421-019-04083-zDOI Listing
April 2019
1 Read

Prevention of Long-term Adverse Health Outcomes With Cardiorespiratory Fitness and Physical Activity in Childhood Acute Lymphoblastic Leukemia Survivors.

J Pediatr Hematol Oncol 2019 Jan 25. Epub 2019 Jan 25.

Laboratory of Pathophysiology of EXercise (LPEX), School of Kinesiology and Physical Activity Sciences, Faculty of Medicine, University of Montreal.

Background: Most childhood acute lymphoblastic leukemia (ALL) survivors develop chronic treatment-related adverse effects several years after the end of therapy. A regular practice of physical activity and a good cardiorespiratory fitness have the potential to reduce the risk of chronic disease and improve quality of life. The aim of this study was to evaluate in a cohort of ALL survivors, the association between a good cardiorespiratory fitness or the respect of physical activity guidelines and major long-term health outcomes. Read More

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http://dx.doi.org/10.1097/MPH.0000000000001426DOI Listing
January 2019
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Exercise-Based Cardiac Rehabilitation with and Without Neuromuscular Electrical Stimulation and its Effect on Exercise Tolerance and Life Quality of Persons with Chronic Heart Failure.

J Hum Kinet 2018 Dec 31;65:151-164. Epub 2018 Dec 31.

Department of Physical Therapy, Academy of Physical Education in Katowice, Katowice, Poland.

The study compares the effect of an exercise-based cardiac rehabilitation program with a program combining physical exercise and lower extremity neuromuscular electrical stimulation (NMES) on the recovery of patients with chronic heart failure (CHF) with NYHA II-III symptoms. Seventy two patients with stable CHF were randomly distributed to four groups that received exercise-based cardiac rehabilitation and pharmacological treatment. Groups I and II were additionally administered NMES (35 Hz and 10 Hz, respectively) and in Group III sham NMES was applied. Read More

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http://dx.doi.org/10.2478/hukin-2018-0045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341955PMC
December 2018
1 Read
0.698 Impact Factor

Exercise, ageing and cognitive function - Effects of a personalized physical exercise program in the cognitive function of older adults.

Physiol Behav 2019 Apr 23;202:8-13. Epub 2019 Jan 23.

Polytechnic Institute of Coimbra, Coimbra Health School, Portugal.

Ageing is associated with a progressive decline in cognitive function, which occurs according to heterogeneous trajectories, dependent on multiple physiological and environmental components. To tackle this major challenge, we designed a project to test the effect of a tailored physical exercise intervention program in the cognitive function of a Portuguese elderly cohort, included in the AGA@4life project. The exercise program included aerobic and strength components, prescribed in a personalized approach according to the AGA@4life model, and implemented under direct control of two experienced professionals. Read More

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http://dx.doi.org/10.1016/j.physbeh.2019.01.018DOI Listing
April 2019
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A role for miR-132 in learned safety.

Sci Rep 2019 Jan 24;9(1):528. Epub 2019 Jan 24.

Department of Neurophysiology and Neuropharmacology, Center for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria.

Learned safety is a fear inhibitory mechanism, which regulates fear responses, promotes episodes of safety and generates positive affective states. Despite its potential as experimental model for several psychiatric illnesses, including post-traumatic stress disorder and depression, the molecular mechanisms of learned safety remain poorly understood, We here investigated the molecular mediators of learned safety, focusing on the characterization of miRNA expression in the basolateral amygdala (BLA). Comparing levels of 22 miRNAs in learned safety and learned fear trained mice, six safety-related miRNAs, including three members of the miR-132/-212 family, were identified. Read More

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http://dx.doi.org/10.1038/s41598-018-37054-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346013PMC
January 2019
2 Reads

Plakophilin-2 Truncation Variants in Patients Clinically Diagnosed With Catecholaminergic Polymorphic Ventricular Tachycardia and Decedents With Exercise-Associated Autopsy Negative Sudden Unexplained Death in the Young.

JACC Clin Electrophysiol 2019 Jan 1;5(1):120-127. Epub 2018 Nov 1.

Department of Molecular Pharmacology & Experimental Therapeutics, Windland Smith Rice Sudden Death Genomics Laboratory, Mayo Clinic, Rochester, Minnesota; Department of Cardiovascular Medicine, Division of Heart Rhythm Services, Mayo Clinic, Rochester, Minnesota; Department of Pediatric and Adolescent Medicine, Division of Pediatric Cardiology, Mayo Clinic, Rochester, Minnesota. Electronic address:

Objectives: This study determined if radical plakophilin-2 (PKP2) variants might underlie some cases of clinically diagnosed catecholaminergic polymorphic ventricular tachycardia (CPVT) and exercise-associated, autopsy-negative sudden unexplained death in the young (SUDY).

Background: Pathogenic variants in PKP2 cause arrhythmogenic right ventricular cardiomyopathy (ARVC). Recently, a cardiomyocyte-specific PKP2 knockout mouse model revealed that loss of PKP2 markedly reduced expression of genes critical in intracellular calcium handling. Read More

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http://dx.doi.org/10.1016/j.jacep.2018.09.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394846PMC
January 2019
1 Read

Dilated cardiomyopathy-mediated heart failure induces a unique skeletal muscle myopathy with inflammation.

Skelet Muscle 2019 Jan 24;9(1). Epub 2019 Jan 24.

Heart Lung Vascular Institute, Division of Cardiology, University of Cincinnati, Cincinnati, OH, 45267, USA.

Background: Skeletal muscle myopathy and exercise intolerance are diagnostic hallmarks of heart failure (HF). However, the molecular adaptations of skeletal muscles during dilated cardiomyopathy (DCM)-mediated HF are not completely understood.

Methods: Skeletal muscle structure and function were compared in wild-type (WT) and cardiac myosin binding protein-C null mice (t/t), which develop DCM-induced HF. Read More

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http://dx.doi.org/10.1186/s13395-019-0189-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345027PMC
January 2019
2 Reads

Grapevine Trunk Diseases: A Review of Fifteen Years of Trials for Their Control with Chemicals and Biocontrol Agents.

Plant Dis 2018 Jul 11;102(7):1189-1217. Epub 2018 Jun 11.

SFR Condorcet, Université de Reims Champagne-Ardenne, URVVC EA 4707, Laboratoire Stress, Défenses et Reproduction des Plantes, BP 1039, Reims, Cedex 2 51687, France.

Grapevine trunk diseases (GTDs) represent one of the most important problems for viticulture worldwide. Beyond the original causes of this outbreak in some countries like France, the lack of efficient control protocols and the prohibition of using active ingredients such as sodium arsenite and benzimidazoles, until recently used to reduce the impact of some GTDs but deleterious for humans and the environment, have probably worsened the impact of the diseases, leading to increasing economic losses. Since 1990, searches have been made to find efficient tools to control GTDs, testing a wide range of active ingredients and biocontrol agents. Read More

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http://dx.doi.org/10.1094/PDIS-08-17-1181-FEDOI Listing
July 2018
1 Read

The Effects of Quercetin Supplementation on Eccentric Exercise-Induced Muscle Damage.

Nutrients 2019 Jan 21;11(1). Epub 2019 Jan 21.

Laboratory of Exercise Physiology-Department of Movement, Human and Health Sciences, Università degli Studi di Roma "Foro Italico", Piazza Lauro De Bosis 6, 00135 Roma, Italy.

The aim of the present investigation was to test the hypothesis that quercetin (Q) may prevent the strength loss and neuromuscular impairment associated with eccentric exercise-induced muscle damage (EEIMD). Twelve young men (26.1 ± 3. Read More

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http://dx.doi.org/10.3390/nu11010205DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356612PMC
January 2019

Chitosan Oligosaccharides Induce Apoptosis in Human Renal Carcinoma via Reactive-Oxygen-Species-Dependent Endoplasmic Reticulum Stress.

J Agric Food Chem 2019 Feb 30;67(6):1691-1701. Epub 2019 Jan 30.

Department of Food Sciences and Engineering, School of Chemistry and Chemical Engineering , Harbin Institute of Technology , 92 West Dazhi Street , Nangang District, Harbin , Heilongjiang 150001 , People's Republic of China.

In recent years, various studies have confirmed the role of natural products as effective cancer prevention and treatment drugs. The present study demonstrated that chitosan oligosaccharide (COS) from shells of shrimp and crab caused an inhibitory effect on the proliferation of human renal carcinoma in vitro and in vivo. First, the in vivo biodistribution of COS was investigated by the synthesis of cyanine-7-labeled COS (COS-Cy7) following tail vein injection. Read More

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http://dx.doi.org/10.1021/acs.jafc.8b06941DOI Listing
February 2019
18 Reads

Safety, pharmacodynamics, and potential benefit of omaveloxolone in Friedreich ataxia.

Ann Clin Transl Neurol 2019 Jan 10;6(1):15-26. Epub 2018 Nov 10.

Reata Pharmaceuticals 2801 Gateway Drive Suite 150 Irving Texas 75063.

Objective: Previous studies have demonstrated that suppression of Nrf2 in Friedreich ataxia tissues contributes to excess oxidative stress, mitochondrial dysfunction, and reduced ATP production. Omaveloxolone, an Nrf2 activator and NF-kB suppressor, targets dysfunctional inflammatory, metabolic, and bioenergetic pathways. The dose-ranging portion of this Phase 2 study assessed the safety, pharmacodynamics, and potential benefit of omaveloxolone in Friedreich ataxia patients (NCT02255435). Read More

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http://dx.doi.org/10.1002/acn3.660DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331199PMC
January 2019
4 Reads

Continuous exercise induces airway epithelium damage while a matched-intensity and volume intermittent exercise does not.

Respir Res 2019 Jan 17;20(1):12. Epub 2019 Jan 17.

URePSSS, Unité de Recherche Pluridisciplinaire Sport, Santé, Société, Lille, France.

Background: While continuous exercise (CE) induces greater ventilation ([Formula: see text]) when compared to intermittent exercise (IE), little is known of the consequences on airway damage. Our aim was to investigate markers of epithelial cell damage - i.e. Read More

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http://dx.doi.org/10.1186/s12931-019-0978-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337858PMC
January 2019
1 Read

International Triadin Knockout Syndrome Registry.

Circ Genom Precis Med 2019 Feb;12(2):e002419

Windland Smith Rice Sudden Death Genomics Laboratory, Department of Molecular Pharmacology and Experimental Therapeutics, Division of Pediatric Cardiology, Department of Pediatric and Adolescent Medicine, and Division of Heart Rhythm Services, Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN (D.J.C., D.J.T., J.R.G., J.M.B., R.K.R., M.J.A.).

Background: Triadin knockout syndrome (TKOS) is a rare, inherited arrhythmia syndrome caused by recessive null mutations in TRDN-encoded cardiac triadin. Based previously on 5 triadin null patients, TKOS has been characterized by extensive T-wave inversions, transient QT prolongation, and severe disease expression of exercise-induced cardiac arrest in early childhood refractory to conventional therapy.

Methods: We have established the International Triadin Knockout Syndrome Registry to include patients who have genetically proven homozygous/compound heterozygous TRDN null mutations. Read More

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http://dx.doi.org/10.1161/CIRCGEN.118.002419DOI Listing
February 2019
17 Reads

Resilience characteristics and prior life stress determine anticipatory response to acute social stress in children aged 7-11 years.

Br J Health Psychol 2019 Jan 13. Epub 2019 Jan 13.

Department of Health, University of Bath, UK.

Objectives: To assess the interplay of prior life stress and characteristics of resilience in determining how children cope with potentially stressful situations, using a two-phase study that triangulates parent-child dyadic interview data with subsequent experience of an acute laboratory stressor in 7-11-year-olds.

Methods: Participants (n = 34) were designated as being in one of four groups based on high/low levels of prior stress experience and high/low resilience ratings assessed during at-home interviews and from questionnaires measuring recent life events, hassles, and trait coping. During a subsequent laboratory stress protocol, salivary cortisol and heart rate were monitored, and a verbal subjective report was provided. Read More

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http://dx.doi.org/10.1111/bjhp.12353DOI Listing
January 2019
1 Read

SR Ca leak in skeletal muscle fibers acts as an intracellular signal to increase fatigue resistance.

J Gen Physiol 2019 Jan 11. Epub 2019 Jan 11.

Department of Physiology and Pharmacology, Biomedicum C5, Karolinska Institutet, Stockholm, Sweden

Effective practices to improve skeletal muscle fatigue resistance are crucial for athletes as well as patients with dysfunctional muscles. To this end, it is important to identify the cellular signaling pathway that triggers mitochondrial biogenesis and thereby increases oxidative capacity and fatigue resistance in skeletal muscle fibers. Here, we test the hypothesis that the stress induced in skeletal muscle fibers by endurance exercise causes a reduction in the association of FK506-binding protein 12 (FKBP12) with ryanodine receptor 1 (RYR1). Read More

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http://www.jgp.org/lookup/doi/10.1085/jgp.201812152
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http://dx.doi.org/10.1085/jgp.201812152DOI Listing
January 2019
14 Reads

Women Experience the Same Ergogenic Response to Caffeine as Men.

Med Sci Sports Exerc 2019 Jan 8. Epub 2019 Jan 8.

School of Human Movement and Nutrition Sciences, The University of Queensland, Australia.

Purpose: This study aimed to determine if 1) consumption of caffeine improves endurance cycling performance in women, and 2) sex differences exist in the magnitude of the ergogenic and plasma responses to caffeine supplementation.

Methods: Twenty-seven (11 women and 16 men) endurance-trained cyclists and triathletes participated in this randomized, double-blind, placebo-controlled, crossover study. Participants completed an incremental exercise test to exhaustion, two familiarization trials and two performance trials. Read More

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http://dx.doi.org/10.1249/MSS.0000000000001885DOI Listing
January 2019

Exercise-induced hypoalgesia: A meta-analysis of exercise dosing for the treatment of chronic pain.

PLoS One 2019 9;14(1):e0210418. Epub 2019 Jan 9.

Department of Biological Sciences, Duquesne University, Pittsburgh, Pennsylvania, United States of America.

Objective: Increasing evidence purports exercise as a first-line therapeutic for the treatment of nearly all forms of chronic pain. However, knowledge of efficacious dosing respective to treatment modality and pain condition is virtually absent in the literature. The purpose of this analysis was to calculate the extent to which exercise treatment shows dose-dependent effects similar to what is seen with pharmacological treatments. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0210418PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326521PMC
January 2019