9,561 results match your criteria Pharmacological Stress Testing


Safety, pharmacodynamics, and potential benefit of omaveloxolone in Friedreich ataxia.

Ann Clin Transl Neurol 2019 Jan 10;6(1):15-26. Epub 2018 Nov 10.

Reata Pharmaceuticals 2801 Gateway Drive Suite 150 Irving Texas 75063.

Objective: Previous studies have demonstrated that suppression of Nrf2 in Friedreich ataxia tissues contributes to excess oxidative stress, mitochondrial dysfunction, and reduced ATP production. Omaveloxolone, an Nrf2 activator and NF-kB suppressor, targets dysfunctional inflammatory, metabolic, and bioenergetic pathways. The dose-ranging portion of this Phase 2 study assessed the safety, pharmacodynamics, and potential benefit of omaveloxolone in Friedreich ataxia patients (NCT02255435). Read More

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http://dx.doi.org/10.1002/acn3.660DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331199PMC
January 2019

Continuous exercise induces airway epithelium damage while a matched-intensity and volume intermittent exercise does not.

Respir Res 2019 Jan 17;20(1):12. Epub 2019 Jan 17.

URePSSS, Unité de Recherche Pluridisciplinaire Sport, Santé, Société, Lille, France.

Background: While continuous exercise (CE) induces greater ventilation ([Formula: see text]) when compared to intermittent exercise (IE), little is known of the consequences on airway damage. Our aim was to investigate markers of epithelial cell damage - i.e. Read More

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http://dx.doi.org/10.1186/s12931-019-0978-1DOI Listing
January 2019

International Triadin Knockout Syndrome Registry: The Clinical Phenotype and Treatment Outcomes of Patients with Triadin Knockout Syndrome.

Circ Genom Precis Med 2019 Jan 16. Epub 2019 Jan 16.

Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN.

Background: Triadin knockout syndrome (TKOS) is a rare, inherited arrhythmia syndrome caused by recessive null mutations in TRDN-encoded cardiac triadin. Based previously on five TRDN null patients, TKOS has been characterized by extensive T-wave inversions, transient QT prolongation, and severe disease expression of exercise-induced cardiac arrest in early childhood refractory to conventional therapy.

Methods: We have established the International Triadin Knockout Syndrome Registry (ITKOSR) to include patients who have genetically proven homozygous/compound heterozygous TRDN null mutations. Read More

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http://dx.doi.org/10.1161/CIRCGEN.118.002419DOI Listing
January 2019
6 Reads

Resilience characteristics and prior life stress determine anticipatory response to acute social stress in children aged 7-11 years.

Br J Health Psychol 2019 Jan 13. Epub 2019 Jan 13.

Department of Health, University of Bath, UK.

Objectives: To assess the interplay of prior life stress and characteristics of resilience in determining how children cope with potentially stressful situations, using a two-phase study that triangulates parent-child dyadic interview data with subsequent experience of an acute laboratory stressor in 7-11-year-olds.

Methods: Participants (n = 34) were designated as being in one of four groups based on high/low levels of prior stress experience and high/low resilience ratings assessed during at-home interviews and from questionnaires measuring recent life events, hassles, and trait coping. During a subsequent laboratory stress protocol, salivary cortisol and heart rate were monitored, and a verbal subjective report was provided. Read More

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http://dx.doi.org/10.1111/bjhp.12353DOI Listing
January 2019

SR Ca leak in skeletal muscle fibers acts as an intracellular signal to increase fatigue resistance.

J Gen Physiol 2019 Jan 11. Epub 2019 Jan 11.

Department of Physiology and Pharmacology, Biomedicum C5, Karolinska Institutet, Stockholm, Sweden

Effective practices to improve skeletal muscle fatigue resistance are crucial for athletes as well as patients with dysfunctional muscles. To this end, it is important to identify the cellular signaling pathway that triggers mitochondrial biogenesis and thereby increases oxidative capacity and fatigue resistance in skeletal muscle fibers. Here, we test the hypothesis that the stress induced in skeletal muscle fibers by endurance exercise causes a reduction in the association of FK506-binding protein 12 (FKBP12) with ryanodine receptor 1 (RYR1). Read More

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http://www.jgp.org/lookup/doi/10.1085/jgp.201812152
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http://dx.doi.org/10.1085/jgp.201812152DOI Listing
January 2019
7 Reads

Women Experience the Same Ergogenic Response to Caffeine as Men.

Med Sci Sports Exerc 2019 Jan 8. Epub 2019 Jan 8.

School of Human Movement and Nutrition Sciences, The University of Queensland, Australia.

Purpose: This study aimed to determine if 1) consumption of caffeine improves endurance cycling performance in women, and 2) sex differences exist in the magnitude of the ergogenic and plasma responses to caffeine supplementation.

Methods: Twenty-seven (11 women and 16 men) endurance-trained cyclists and triathletes participated in this randomized, double-blind, placebo-controlled, crossover study. Participants completed an incremental exercise test to exhaustion, two familiarization trials and two performance trials. Read More

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http://dx.doi.org/10.1249/MSS.0000000000001885DOI Listing
January 2019

Exercise-induced hypoalgesia: A meta-analysis of exercise dosing for the treatment of chronic pain.

PLoS One 2019 9;14(1):e0210418. Epub 2019 Jan 9.

Department of Biological Sciences, Duquesne University, Pittsburgh, Pennsylvania, United States of America.

Objective: Increasing evidence purports exercise as a first-line therapeutic for the treatment of nearly all forms of chronic pain. However, knowledge of efficacious dosing respective to treatment modality and pain condition is virtually absent in the literature. The purpose of this analysis was to calculate the extent to which exercise treatment shows dose-dependent effects similar to what is seen with pharmacological treatments. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0210418PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326521PMC
January 2019

Short-Term Environmental Stimulation Spatiotemporally Modulates Specific Serotonin Receptor Gene Expression and Behavioral Pharmacology in a Sexually Dimorphic Manner in Huntington's Disease Transgenic Mice.

Front Mol Neurosci 2018 10;11:433. Epub 2018 Dec 10.

Florey Institute of Neuroscience and Mental Health, Melbourne Brain Centre, University of Melbourne, Parkville, VIC, Australia.

Huntington's disease (HD) is a neurodegenerative disorder caused by a tandem repeat mutation encoding an expanded polyglutamine tract in the huntingtin protein, which leads to cognitive, psychiatric and motor dysfunction. Exposure to environmental enrichment (EE), which enhances levels of cognitive stimulation and physical activity, has therapeutic effects on cognitive, affective and motor function of transgenic HD mice. The present study investigated gene expression changes and behavioral pharmacology in male and female R6/1 transgenic HD mice at an early time-point in HD progression associated with onset of cognitive and affective abnormalities, following EE and exercise (wheel running) interventions. Read More

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http://dx.doi.org/10.3389/fnmol.2018.00433DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295568PMC
December 2018
2 Reads

Effects of caffeine ingestion on the diurnal variation of cognitive and repeated high-intensity performances.

Pharmacol Biochem Behav 2019 Feb 3;177:69-74. Epub 2019 Jan 3.

Institut Supérieur du Sport et de l'Education Physique de Sfax, Université de Sfax, Tunisie; Activité Physique: Sport et Santé, UR18JS01, Observatoire National du Sport, Tunis, Tunisie.

The purpose of this study was to evaluate the effects of caffeine ingestion on the daily variation of cognitive (i.e., reaction time (RT), attention) and repeated high-intensity exercise performances. Read More

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http://dx.doi.org/10.1016/j.pbb.2019.01.001DOI Listing
February 2019

The quest for synergy between physical exercise and cognitive stimulation via exergaming in people with dementia: a randomized controlled trial.

Alzheimers Res Ther 2019 Jan 5;11(1). Epub 2019 Jan 5.

Radboud University Medical Center, Radboudumc Alzheimer Center, Nijmegen, the Netherlands.

Background: Exercise is often proposed as a non-pharmacological intervention to delay cognitive decline in people with dementia, but evidence remains inconclusive. Previous studies suggest that combining physical exercise with cognitive stimulation may be more successful in this respect. Exergaming is a promising intervention in which physical exercise is combined with cognitively challenging tasks in a single session. Read More

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http://dx.doi.org/10.1186/s13195-018-0454-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320611PMC
January 2019

Pterostilbene, an active component of the dragon's blood extract, acts as an antidepressant in adult rats.

Psychopharmacology (Berl) 2019 Jan 4. Epub 2019 Jan 4.

School of Life Science, Beijing Institute of Technology, Beijing, 100081, People's Republic of China.

Background: Hippocampal neurogenesis has been widely considered as one of the potential biological mechanisms for the treatment of depression caused by chronic stress. Many natural products have been reported to be beneficial for neurogenesis.

Objectives: The present study is designed to investigate the effect of dragon's blood extract (DBE) and its biologically active compound, pterostilbene (PTE), on hippocampal neurogenesis. Read More

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http://dx.doi.org/10.1007/s00213-018-5138-7DOI Listing
January 2019
3.875 Impact Factor

Tempering aversive/traumatic memories with cannabinoids: a review of evidence from animal and human studies.

Psychopharmacology (Berl) 2019 Jan 2. Epub 2019 Jan 2.

Department of Pharmacology, Medical School of Ribeirão Preto, University of São Paulo (FMRP/USP), Av Bandeirantes 3900, Monte Alegre, 14049900, Ribeirão Preto, São Paulo, Brazil.

Rationale: Aversive learning and memory are essential to cope with dangerous and stressful stimuli present in an ever-changing environment. When this process is dysfunctional, however, it is associated with posttraumatic stress disorder (PTSD). The endocannabinoid (eCB) system has been implicated in synaptic plasticity associated with physiological and pathological aversive learning and memory. Read More

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http://dx.doi.org/10.1007/s00213-018-5127-xDOI Listing
January 2019
1 Read

Effects of Six-Month Aerobic Exercise Intervention on Sleep in Healthy Older Adults in the Study: A Pilot Study.

J Alzheimers Dis Rep 2018 Dec 24;2(1):229-238. Epub 2018 Dec 24.

Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.

Background: Sleep disturbances have been shown to be associated with the presence of the apolipoprotein () 4 allele, the well-known genetic risk factor for late-onset sporadic Alzheimer's disease (AD).

Objective: This study quantifies the effects of a six-month aerobic exercise intervention on objective and subjective sleep quality in middle-aged to older individuals including those at increased genetic risk for late-onset sporadic Alzheimer's disease (AD), who carry the apolipoprotein () 4 risk allele.

Methods: 199 sedentary men and women without significant cognitive impairments were enrolled in the study, a quasi-experimental single group pre-test/post-test study with no control group. Read More

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https://www.medra.org/servlet/aliasResolver?alias=iospress&a
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http://dx.doi.org/10.3233/ADR-180079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311349PMC
December 2018
2 Reads

Plasmodium falciparum PFI1625c offers an opportunity to design potent anti-malarials: Biochemical characterization and testing potentials in drug discovery.

Acta Trop 2018 Dec 27;191:116-127. Epub 2018 Dec 27.

Malaria Research Group, Department of Biosciences and Bioengineering, Indian Institute of Technology-Guwahati, Guwahati, 781039, Assam, India. Electronic address:

Putative PFI1625c was cloned, over-expressed and purified to homogeneity. It is a 56.2 kDa monomeric protease which preferentially catalyzes the degradation of gelatin with a K = 30μM. Read More

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http://dx.doi.org/10.1016/j.actatropica.2018.12.033DOI Listing
December 2018
1 Read

Veterans have greater variability in their perception of binocular alignment.

PLoS One 2018 26;13(12):e0209622. Epub 2018 Dec 26.

War Related Illness and Injury Study Center, Department of Veteran Affairs, NJ, United States of America.

Introduction: A significant population of our wounded veterans suffer long-term functional consequences of visual deficit, disorientation, dizziness, and an impaired ability to read. These symptoms may be related to damage within the otolith pathways that contribute to ocular alignment. The purpose of this study was to compare perception of vertical and torsional ocular alignment between veterans and healthy controls in an upright and supine test position. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0209622PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306227PMC
December 2018
2 Reads

Efficacy and mechanisms of combined aerobic exercise and cognitive training in mild cognitive impairment: study protocol of the ACT trial.

Trials 2018 Dec 22;19(1):700. Epub 2018 Dec 22.

Department of Radiology, Mayo Clinic, Rochester, MN, USA.

Background: Developing non-pharmacological interventions with strong potential to prevent or delay the onset of Alzheimer's disease (AD) in high-risk populations is critical. Aerobic exercise and cognitive training are two promising interventions. Aerobic exercise increases aerobic fitness, which in turn improves brain structure and function, while cognitive training improves selective brain function intensively. Read More

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http://dx.doi.org/10.1186/s13063-018-3054-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303946PMC
December 2018

Comparing effects of 4 months of two self-administered exercise training programs on physical performance in patients with chronic kidney disease: RENEXC - A randomized controlled trial.

PLoS One 2018 20;13(12):e0207349. Epub 2018 Dec 20.

Department of Nephrology, Institution of Clinical Sciences, Faculty of Medicine, Lund University, Skåne University Hospital, Lund, Sweden.

Background: Exercise training is recommended to patients with chronic kidney disease (CKD). However, the level of evidence is still low. This randomized controlled trial (RCT) compared two different and self-administered exercise training programs in a representative CKD population. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0207349PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6301660PMC
December 2018

Sex-Specific Association Between Coronary Artery Disease Severity and Myocardial Ischemia Induced by Mental Stress.

Psychosom Med 2019 Jan;81(1):57-66

From the Department of Epidemiology (Almuwaqqat, Sullivan, Lima, Shah, Fang, Li, O'Neal, Vaccarino), Rollins School of Public Health, Emory University, Atlanta, Georgia; Division of Hospital Medicine (Almuwaqqat), Division of Cardiology, Department of Medicine, (Almuwaqqat, Hammadah, Lima, Shah, Abdelhadi, Wilmot, Al Mheid, O'Neal, Quyyumi, Vaccarino), and Department of Psychiatry and Behavioral Sciences (Bremner), Emory University School of Medicine, Atlanta, Georgia; Atlanta VA Medical Center (Shah, Bremner), Decatur, Georgia; Department of Radiology and Imaging Sciences (Garcia, Nye), Emory University School of Medicine, Atlanta, Georgia; Department of Biostatistics and Bioinformatics (Elon), Rollins School of Public Health, Emory University, Atlanta, Georgia; and Mazankowski Alberta Heart Institute (Raggi), University of Alberta, Edmonton, Canada.

Objective: It is unclear whether mental stress-induced myocardial ischemia (MSIMI) is related to obstructive coronary artery disease (CAD). We examined this question and contrasted results with ischemia induced by conventional stress testing (CSIMI). Because women are more susceptible to ischemia without coronary obstruction than men, we examined sex differences. Read More

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http://dx.doi.org/10.1097/PSY.0000000000000636DOI Listing
January 2019

Safely Identifying Emergency Department Patients With Acute Chest Pain for Early Discharge.

Circulation 2018 Nov;138(22):2456-2468

Department of Emergency Medicine (S.A.M., B.C.H., C.D.M.), Wake Forest School of Medicine, Winston-Salem, NC.

Background: The HEART Pathway (history, ECG, age, risk factors, and initial troponin) is an accelerated diagnostic protocol designed to identify low-risk emergency department patients with chest pain for early discharge without stress testing or angiography. The objective of this study was to determine whether implementation of the HEART Pathway is safe (30-day death and myocardial infarction rate <1% in low-risk patients) and effective (reduces 30-day hospitalizations) in emergency department patients with possible acute coronary syndrome.

Methods: A prospective pre-post study was conducted at 3 US sites among 8474 adult emergency department patients with possible acute coronary syndrome. Read More

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.036528DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309794PMC
November 2018
3 Reads

Molecular adaptations in human subcutaneous adipose tissue after ten weeks of endurance exercise training in healthy males.

J Appl Physiol (1985) 2018 Dec 20. Epub 2018 Dec 20.

Department of Biomedicine, Aarhus University Hospital, Denmark.

Endurance exercise training induces adaptations in metabolically active organs, but adaptations in human subcutaneous adipose tissue (scAT) remains incompletely understood. Based on animal studies, we hypothesized that endurance exercise training would increase the expression of proteins involved in lipolysis and glucose uptake in scAT. To test these hypotheses, nineteen young and healthy males were randomized to either endurance exercise training (TR; age 18-24 yr; BMI 19. Read More

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http://dx.doi.org/10.1152/japplphysiol.00989.2018DOI Listing
December 2018

Human kidney on a chip assessment of polymyxin antibiotic nephrotoxicity.

JCI Insight 2018 Dec 20;3(24). Epub 2018 Dec 20.

Department of Pharmaceutics.

Drug-induced kidney injury, largely caused by proximal tubular intoxicants, limits development and clinical use of new and approved drugs. Assessing preclinical nephrotoxicity relies on animal models that are frequently insensitive; thus, potentially novel techniques - including human microphysiological systems, or "organs on chips" - are proposed to accelerate drug development and predict safety. Polymyxins are potent antibiotics against multidrug-resistant microorganisms; however, clinical use remains restricted because of high risk of nephrotoxicity and limited understanding of toxicological mechanisms. Read More

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http://dx.doi.org/10.1172/jci.insight.123673DOI Listing
December 2018
5 Reads

Plasma asymmetric dimethylarginine concentrations are not related to differences in maximal oxygen uptake in endurance trained and untrained men.

Exp Physiol 2018 Nov 22. Epub 2018 Nov 22.

University of Lille, University of Artois, University of Littoral Côte, d'Opale, EA 7369 - URePSSS, Pluridisciplinary Research Unit, "Sport, Health and Society", F-59000, Lille, France.

New Findings: What is the central question of this study? Is there an association of plasma concentration of asymmetric dimethylarginine, which is related to exercise capacity in patients with cardiovascular diseases, with oxygen delivery and subsequently exercise capacity in healthy subjects in the absence of the potentially confounding influence of inflammation and oxidative stress? What is the main finding and its importance? Plasma asymmetric dimethylarginine concentrations are not related to exercise capacity in healthy subjects, while O delivery in the working skeletal muscle during the maximal graded-exercise test is not associated with any of the l-arginine analogues. ADMA alone does not play a crucial role in local muscle perfusion and in maintaining exercise capacity.

Abstract: Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide (NO) synthesis that could limit oxygen (O ) delivery in the working skeletal muscles by altering endothelium-dependent vasodilatation. Read More

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http://dx.doi.org/10.1113/EP087398DOI Listing
November 2018

Kaempferol attenuates diabetic nephropathy by inhibiting RhoA/Rho-kinase mediated inflammatory signalling.

Biomed Pharmacother 2019 Jan 15;109:1610-1619. Epub 2018 Nov 15.

Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER)-Ahmedabad, Gandhinagar, 382355, Gujarat, India; Department of Biotechnology, National Institute of Pharmaceutical Education and Research (NIPER)-Ahmedabad, Gandhinagar, 382355, Gujarat, India. Electronic address:

RhoA/Rho-associated coiled-coil forming protein serine/threonine kinase (ROCK) has appeared as a potential therapeutic target in numerous diseases, because of its preventing action on various enzymes providing antioxidant and cytoprotective action. Progression and pathophysiology of diabetic nephropathy have also shown potential involvement of oxidative stress and inflammatory pathways. In the present study, we investigated the effect of kaempferol on hyperglycemia-induced activation of RhoA kinase and associated inflammatory signaling cascade. Read More

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http://dx.doi.org/10.1016/j.biopha.2018.10.195DOI Listing
January 2019

A Novel, Synthetic, Neuroactive Steroid Is Effective at Decreasing Depression-Like Behaviors and Improving Maternal Care in Preclinical Models of Postpartum Depression.

Front Endocrinol (Lausanne) 2018 23;9:703. Epub 2018 Nov 23.

Neuroscience Department, Tufts University School of Medicine, Boston, MA, United States.

Preclinical testing of treatments for postpartum depression (PPD) has been limited due to the lack of available animal models of such a complex disorder. To address this limitation, our laboratory has generated unique preclinical mouse models that exhibit abnormal postpartum behaviors. Mice with a loss or reduction in the expression of the GABA receptor (GABAR) δ subunit ( or , respectively) and mice that lack the K/Cl co-transporter, KCC2, specifically in corticotropin-releasing hormone (CRH) neurons (KCC2/Crh mice) exhibit depression-like behaviors restricted to the postpartum period and deficits in maternal care, which serve as useful tools for testing novel therapeutic compounds. Read More

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http://dx.doi.org/10.3389/fendo.2018.00703DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6265503PMC
November 2018

The 18 kDa Translocator Protein (TSPO) Overexpression in Hippocampal Dentate Gyrus Elicits Anxiolytic-Like Effects in a Mouse Model of Post-traumatic Stress Disorder.

Front Pharmacol 2018 23;9:1364. Epub 2018 Nov 23.

State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, Beijing, China.

The translocator protein (18 kDa) (TSPO) recently attracted increasing attention in the pathogenesis of post-traumatic stress disorder (PTSD). This study is testing the hypothesis that the overexpression of TSPO in hippocampus dentate gyrus (DG) could alleviate the anxiogenic-like response in the mice model of PTSD induced by foot-shock. In this study, hippocampal DG overexpression of TSPO significantly reversed the increase of the contextual freezing response, the decrease of the percentage of both entries into and time spent in the open arms in elevated plus maze test and the decrease of the account of crossings from the dark to light compartments in light-dark transition test induced by electric foot-shocks procedure. Read More

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http://dx.doi.org/10.3389/fphar.2018.01364DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6265405PMC
November 2018

Evaluation of the effects of chemotherapy-induced fatigue and pharmacological interventions in multiple mouse behavioral assays.

Behav Brain Res 2019 Mar 7;360:255-261. Epub 2018 Dec 7.

National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD, 20892, USA. Electronic address:

Fatigue is a common symptom in many diseases and disorders and can reduce quality of life, yet lacks an adequate pharmacological intervention. To identify and develop such interventions, and to better understand fatigue, additional preclinical research is necessary. However, despite numerous mouse behavioral assays reportedly detecting fatigue-like behavior, the assumption that fatigue-like behavior is detected in many assays has not been validated through a cross-assay study. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01664328183142
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http://dx.doi.org/10.1016/j.bbr.2018.12.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328057PMC
March 2019
3 Reads

Finite Element Analysis of the Mouse Distal Femur with Tumor Burden in Response to Knee Loading.

Int J Orthop (Hong Kong) 2018 28;5(1):863-871. Epub 2018 Feb 28.

Department of Mechanical Engineering, Indiana University Purdue University Indianapolis, Indianapolis, IN 46202, USA.

Breast cancer-associated bone metastasis induces bone loss, followed by an increased risk of bone fracture. To develop a strategy for preventing tumor growth and protecting bone, an understanding of the mechanical properties of bone under tumor burden is indispensable. Using a mouse model of mammary tumor, we conducted finite element analysis (FEA) of two bone samples from the distal femur. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261479PMC
February 2018
6 Reads

Developing an optimized strategy with transcranial direct current stimulation to enhance the endogenous pain control system in fibromyalgia.

Expert Rev Med Devices 2018 Dec 3;15(12):863-873. Epub 2018 Dec 3.

a Laboratory of Neuromodulation & Center for Clinical Research Learning, Department of Physical Medicine and Rehabilitation , Spaulding Rehabilitation Hospital, Harvard Medical School , Boston , MA , USA.

Introduction: Fibromyalgia affects more than 5 million people in the United States and has a detrimental impact on individuals' quality of life. Current pharmacological treatments provide limited benefits to relieve the pain of fibromyalgia, along with a risk of adverse effects; a scenario that explains the increasing interest for multimodal approaches. A tailored strategy to focus on this dysfunctional endogenous pain inhibitory system is transcranial direct current stimulation (tDCS) of the primary motor cortex. Read More

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http://dx.doi.org/10.1080/17434440.2018.1551129DOI Listing
December 2018
1 Read

A systematic comparison of exercise training protocols on animal models of cardiovascular capacity.

Life Sci 2019 Jan 3;217:128-140. Epub 2018 Dec 3.

National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest of China/CGDB, Shaanxi Normal University College of Life Sciences, Xi'an 710119, China. Electronic address:

Cardiovascular disease (CVD) is a major global cause of mortality, which has prompted numerous studies seeking to reduce the risk of heart failure and sudden cardiac death. While regular physical activity is known to improve CVD associated morbidity and mortality, the optimal duration, frequency, and intensity of exercise remains unclear. To address this uncertainty, various animal models have been used to study the cardioprotective effects of exercise and related molecular mechanism such as the mice training models significantly decrease size of myocardial infarct by affecting Kir6. Read More

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http://dx.doi.org/10.1016/j.lfs.2018.12.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320317PMC
January 2019
2 Reads
2.702 Impact Factor

Promotes Neuroprotection Dependently of AKT and ERK Phosphorylation but Does Not Prevent Mitochondrial Damage by 6-OHDA.

Oxid Med Cell Longev 2018 29;2018:2131895. Epub 2018 Oct 29.

Oxidative Stress and Cell Signaling Research Group, Centro Interdisciplinar de Pesquisa em Biotecnologia, Universidade Federal do Pampa, Campus São Gabriel, 97300-000 São Gabriel, RS, Brazil.

Parkinson's disease is a degenerative and progressive illness characterized by the degeneration of dopaminergic neurons. 6-hydroxydopamine (6-OHDA) is a widespread model for induction of molecular and behavioral alterations similar to Parkinson and has contributed for testing of compounds with neuroprotective potential. The Brazilian plant is used in folk medicine for treatment of several illnesses; however, the knowledge about toxicology and biological effects for this plant is very rare. Read More

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http://dx.doi.org/10.1155/2018/2131895DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6231360PMC
January 2019
5 Reads

Influence of weight loss on pulmonary function and levels of adipokines among asthmatic individuals with obesity: One-year follow-up.

Respir Med 2018 Dec 21;145:48-56. Epub 2018 Oct 21.

Department of Surgery, Faculty of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil.

Background: Individuals with obesity are more likely to develop asthma, but the exact mechanism is still uncertain and several hypotheses have been raised, such as the release of inflammatory mediators secreted by adipose tissue.

Objective: To assess the effects of weight loss in patients submitted to bariatric surgery on pulmonary and systemic inflammation.

Method: The study evaluated patients undergoing bariatric surgery (Roux-en-Y gastric bypass) with the diagnosis of asthma, except smokers. Read More

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http://dx.doi.org/10.1016/j.rmed.2018.10.017DOI Listing
December 2018
2 Reads

Neuroplasticity-related correlates of environmental enrichment combined with physical activity differ between the sexes.

Eur Neuropsychopharmacol 2018 Nov 26. Epub 2018 Nov 26.

Department of Pharmacology, Medical School, National and Kapodistrian University of Athens, Mikras Asias 75, Athens 11527, Greece. Electronic address:

Environmental enrichment (EE), comprising positive physical (exercise) and cognitive stimuli, influences neuronal structure and usually improves brain function. The promise of EE as a preventative strategy against neuropsychiatric disease is especially high during early postnatal development when the brain is still amenable to reorganization. Despite the fact that male and female brains differ in terms of connectivity and function that may reflect early life experiences, knowledge of the neural substrates and mechanisms by which such changes arise remains limited. Read More

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http://dx.doi.org/10.1016/j.euroneuro.2018.11.1107DOI Listing
November 2018

Dosimetry, biodistribution, and safety of flurpiridaz F 18 in healthy subjects undergoing rest and exercise or pharmacological stress PET myocardial perfusion imaging.

J Nucl Cardiol 2018 Nov 28. Epub 2018 Nov 28.

Lantheus Medical Imaging, Billerica, MA, USA.

The objectives of this study were to evaluate radiation dosimetry, biodistribution, human safety, and tolerability of F-labeled flurpiridaz (Flurpiridaz) in normal subjects undergoing rest and separate-day exercise or adenosine pharmacological stress PET imaging.

Methods: 12 normal subjects were injected with 58.5 to 121 MBq (1. Read More

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http://dx.doi.org/10.1007/s12350-018-01484-zDOI Listing
November 2018
5 Reads

Non-Pharmacological Treatment for Primary Headaches Prevention and Lifestyle Changes in a Low-Income Community of Brazil: A Randomized Clinical Trial.

Headache 2019 Jan 28;59(1):86-96. Epub 2018 Nov 28.

Instituto do Cérebro, Hospital Israelita Albert Einstein, São Paulo, Brazil.

Background: Primary headaches can be reduced by lifestyle changes, such as stress management and physical activity. However, access to programs focused on behavioral interventions is limited in underserved, poor communities.

Objectives: We performed a randomized open-label clinical trial to test the therapeutic and behavioral effects of aerobic exercise, relaxation, or the combination of both, in individuals with primary headaches of a small, low-income community of the Brazilian Amazon. Read More

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http://doi.wiley.com/10.1111/head.13457
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http://dx.doi.org/10.1111/head.13457DOI Listing
January 2019
1 Read

Extinction of Fear Memory Attenuates Conditioned Cardiovascular Fear Reactivity.

Front Behav Neurosci 2018 13;12:276. Epub 2018 Nov 13.

Department of Pharmacology and Physiology and Institute for Neuroscience, George Washington University, Washington, DC, United States.

Post-traumatic stress disorder (PTSD) is characterized by a heightened emotional and physiological state and an impaired ability to suppress or extinguish traumatic fear memories. Exaggerated physiological responses may contribute to increased cardiovascular disease (CVD) risk in this population, but whether treatment for PTSD can offset CVD risk remains unknown. To further evaluate physiological correlates of fear learning, we used a novel pre-clinical conditioned cardiovascular testing paradigm and examined the effects of Pavlovian fear conditioning and extinction training on mean arterial pressure (MAP) and heart rate (HR) responses. Read More

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https://www.frontiersin.org/article/10.3389/fnbeh.2018.00276
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http://dx.doi.org/10.3389/fnbeh.2018.00276DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6244092PMC
November 2018
8 Reads

Anxiolytic effects of γ-oryzanol in chronically- stressed mice are related to monoamine levels in the brain.

Life Sci 2019 Jan 20;216:119-128. Epub 2018 Nov 20.

Laboratory of Physiology and Pharmacology, School of Advanced Science and Engineering, Waseda University, Tokyo, Japan. Electronic address:

Aims: The present study was aimed to investigate the anxiolytic effect of γ-oryzanol (GORZ) during chronic restraint stress treatment (CRST), which is a well-documented model of stress-related disorders, like anxiety, and its potential molecular mechanisms.

Materials And Methods: In this experiment, 5-week-old male ICR mice were used and the concentration of GORZ was fixed at 0.5% in the mouse standard diet (14% casein, AIN 93 M). Read More

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http://dx.doi.org/10.1016/j.lfs.2018.11.042DOI Listing
January 2019
4 Reads

Balance and mobility in patients with newly diagnosed Parkinson's disease - a five-year follow-up of a cohort in northern Sweden.

Disabil Rehabil 2018 Nov 19:1-10. Epub 2018 Nov 19.

a Department of Community Medicine and Rehabilitation; Physiotherapy , Umeå University , Umeå , Sweden.

Background: The presence of early balance impairment in patients with Parkinson's disease has not been fully investigated.

Purpose: The purpose of this study was to examine balance and mobility, self-perceived unsteadiness, self-reported falls, and effects of medication on balance among patients at their first visit to a neurological clinic and during the ensuing five years.

Materials And Methods: The participants were collected from a prospective longitudinal study. Read More

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http://dx.doi.org/10.1080/09638288.2018.1509240DOI Listing
November 2018
8 Reads

Effects of Probiotic Supplementation on Selected Parameters of Blood Prooxidant-Antioxidant Balance in Elite Athletes: A Double-Blind Randomized Placebo-Controlled Study.

J Hum Kinet 2018 Sep 15;64:111-122. Epub 2018 Oct 15.

Department of Bromatology, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia.

A randomized, double-blind, placebo-controlled study was conducted, in order to evaluate if Lactobacillus helveticus Lafti® L10 (Lallemand Health Solutions, Montreal, Canada) supplementation during three months could influence oxidative markers in the population of elite athletes: triathletes, cyclists and endurance athletes. Twenty-two elite athletes were randomized to either placebo (n = 12) or probiotic (n = 10) groups. The probiotic group received 2x1010 colony forming units of Lafti® L10. Read More

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https://content.sciendo.com/view/journals/hukin/64/1/article
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http://dx.doi.org/10.1515/hukin-2017-0203DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6231349PMC
September 2018
14 Reads

Growth Factor and Intense Pulse Light in Flexor Tendon Repair: A Biomechanical Study at Strength and Gap Resistance.

J Hand Surg Asian Pac Vol 2018 Dec;23(4):463-468

† School of Biochemistry, Swansea University, Swansea, UK.

Background: Flexor tendon injuries are extremely common and they are usually the result of incised traumatic glass or knife injury. The process of tendon healing is a complicated and exceptionally-regimented mechanism that is originated and monitored by a vast number of diverse molecules. One of the most pivotal groups of mediators that are crucial to the healing process are growth factors (GF). Read More

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http://dx.doi.org/10.1142/S2424835518500431DOI Listing
December 2018

Feasibility of vitamin D supplementation interventions to mitigate HIV pre-exposure prophylaxis-related bone mineral density loss: a cross-sectional survey.

Patient Prefer Adherence 2018 16;12:2197-2204. Epub 2018 Oct 16.

Division of Infectious Diseases, St Michael's Hospital, Toronto, ON, Canada,

Background: Daily tenofovir disoproxil fumarate (TDF)/emtricitabine as HIV pre-exposure prophylaxis (PrEP) causes subclinical decreases in bone mineral density (BMD). We surveyed PrEP users to assess feasibility for a clinical trial of vitamin D supplementation to mitigate TDF-induced BMD loss.

Methods: We recruited participants using or starting PrEP in Toronto and Vancouver. Read More

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https://www.dovepress.com/feasibility-of-vitamin-d-supplemen
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http://dx.doi.org/10.2147/PPA.S178403DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6199226PMC
October 2018
8 Reads

Left ventricular blood flow patterns at rest and under dobutamine stress in healthy pigs.

NMR Biomed 2019 Jan 7;32(1):e4022. Epub 2018 Nov 7.

Institute for Biomedical Engineering, University and ETH, Zurich, Zurich, Switzerland.

Intracardiac blood flow patterns are affected by the morphology of cardiac structures and are set up to support the heart's pump function. Exercise affects contractility and chamber size as well as pre- and afterload. The aim of this study was to test the feasibility of four-dimensional phase contrast cardiovascular MRI under pharmacological stress and to study left ventricular blood flow under stress. Read More

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http://doi.wiley.com/10.1002/nbm.4022
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http://dx.doi.org/10.1002/nbm.4022DOI Listing
January 2019
4 Reads

Effect of Inorganic Nitrite vs Placebo on Exercise Capacity Among Patients With Heart Failure With Preserved Ejection Fraction: The INDIE-HFpEF Randomized Clinical Trial.

JAMA 2018 11;320(17):1764-1773

Mayo Clinic, Rochester, Minnesota.

Importance: There are few effective treatments for heart failure with preserved ejection fraction (HFpEF). Short-term administration of inorganic nitrite or nitrate preparations has been shown to enhance nitric oxide signaling, which may improve aerobic capacity in HFpEF.

Objective: To determine the effect of 4 weeks' administration of inhaled, nebulized inorganic nitrite on exercise capacity in HFpEF. Read More

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http://jama.jamanetwork.com/article.aspx?doi=10.1001/jama.20
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http://dx.doi.org/10.1001/jama.2018.14852DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6248105PMC
November 2018
17 Reads

6-shogaol protects against diabetic nephropathy and cardiomyopathy via modulation of oxidative stress/NF-κB pathway.

Pak J Pharm Sci 2018 Sep;31(5(Supplementary)):2109-2117

Department of Pharmacognosy, College of Pharmacy, Umm Al-Qura University, Makkah, Saudi Arabia.

Diabetes dramatically increases the risk of numerous heart and kidney troubles. Diabetic nephropathy (DN) and cardiomyopathy (DC) are major causes of death. The pathophysiology of DN/DC includes inflammatory and oxidative stress mechanisms. Read More

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September 2018
9 Reads

Day-Night Oscillation of Atrogin1 and Timing-Dependent Preventive Effect of Weight-Bearing on Muscle Atrophy.

EBioMedicine 2018 Nov 1;37:499-508. Epub 2018 Nov 1.

Laboratory of Physiology and Pharmacology, School of Advanced Science and Engineering, Waseda University, Tokyo, Japan,. Electronic address:

Background: Atrogin1, which is one of the key genes for the promotion of muscle atrophy, exhibits day-night variation. However, its mechanism and the role of its day-night variation are largely unknown in a muscle atrophic context.

Methods: The mice were induced a muscle atrophy by hindlimb-unloading (HU). Read More

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http://dx.doi.org/10.1016/j.ebiom.2018.10.057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286653PMC
November 2018
3 Reads

Prolonged Sitting Interrupted by 6-Min of High-Intensity Exercise: Circulatory, Metabolic, Hormonal, Thermal, Cognitive, and Perceptual Responses.

Front Physiol 2018 16;9:1279. Epub 2018 Oct 16.

Institute of Sport Science, University of Würzburg, Würzburg, Germany.

The aim was to examine certain aspects of circulatory, metabolic, hormonal, thermoregulatory, cognitive, and perceptual responses while sitting following a brief session of high-intensity interval exercise. Twelve students (five men; age, 22 ± 2 years) performed two trials involving either simply sitting for 180 min (SIT) or sitting for this same period with a 6-min session of high-intensity exercise after 60 min (SIT+HIIT). At T (after 30 min of resting), T (after a 20-min breakfast), T (after sitting for 1 h), T (immediately after the HIIT), T, T, T, and T (30, 60, 90, and 120 min after the HIIT), circulatory, metabolic, hormonal, thermoregulatory, cognitive, and perceptual responses were assessed. Read More

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http://dx.doi.org/10.3389/fphys.2018.01279DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6198043PMC
October 2018
1 Read

Exercise Increases Adiponectin and Reduces Leptin Levels in Prediabetic and Diabetic Individuals: Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Med Sci (Basel) 2018 Oct 30;6(4). Epub 2018 Oct 30.

Department of Nutritional Sciences, Faculty of Life Sciences, University of Vienna, Althanstraβe 14, 1090 Vienna, Austria.

It is speculated that lifestyle interventions known to improve diabetic metabolic state may exert their effects via adipokines. The aim of this systematic review and meta-analysis was to evaluate the chronic effects of physical exercise on adiponectin and leptin levels in adult prediabetic and diabetic individuals. PubMed, Embase, Scopus, The Cochrane Library, clinicaltrials. Read More

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http://dx.doi.org/10.3390/medsci6040097DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318757PMC
October 2018

Postural orthostatic tachycardia syndrome: clinical presentation, aetiology and management.

Authors:
A Fedorowski

J Intern Med 2018 Oct 29. Epub 2018 Oct 29.

Department of Clinical Sciences, Malmö, Lund University, Malmö, Sweden.

Postural orthostatic tachycardia syndrome (POTS) is a variant of cardiovascular autonomic disorder characterized by an excessive heart rate increase on standing and orthostatic intolerance. POTS affects younger individuals 15-45 years old with a distinct female predominance (≈80%). The prevalence ranges between 0. Read More

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http://doi.wiley.com/10.1111/joim.12852
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http://dx.doi.org/10.1111/joim.12852DOI Listing
October 2018
10 Reads

Application of Single Prolonged Stress Induces Post-traumatic Stress Disorder-like Characteristics in Mice.

Acta Med Okayama 2018 Oct;72(5):479-485

Physiology and Pharmacology, School of Health and Social Services, Saitama Prefectural University, Koshigaya, Saitama 343-8540, Japan.

We tried to clarify the applicability of a single prolonged stress (SPS) protocol as post-traumatic stress disorder (PTSD) model in mice. To investigate PTSD pathophysiology, we conducted hypothalamo-pituitary-adrenal (HPA) negative feedback testing at 1, 4, 8 and 12 weeks after the SPS by administrating a dexamethasone (DEX) suppression test. The SPS induced over-suppression of the HPA system by DEX treatment at 8 and 12 weeks. Read More

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http://dx.doi.org/10.18926/AMO/56245DOI Listing
October 2018
1 Read

Selective modulator of peroxisome proliferator-activated receptor-α protects propionic acid induced autism-like phenotypes in rats.

Life Sci 2018 Dec 23;214:106-117. Epub 2018 Oct 23.

Department of Pharmacology, Amity Institute of Pharmacy, Amity University Uttar Pradesh, India; CNS Pharmacology, Conscience Research, Delhi, India. Electronic address:

Aims: The present study investigated the neuropharmacological role of PPAR-α modulator, fenofibrate in postnatal-propionic acid induced symptomatology related with autism spectrum disorders (ASD) in Wistar rats.

Main Methods: The propionic acid (250 mg/kg, p.o. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00243205183067
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http://dx.doi.org/10.1016/j.lfs.2018.10.045DOI Listing
December 2018
7 Reads
2.702 Impact Factor

Anomalous Supradominant Left Circumflex Artery with Rare, Rudimentary Left Anterior Descending Artery.

Cureus 2018 Aug 23;10(8):e3189. Epub 2018 Aug 23.

Dow Medical College, Dow University of Health Sciences, Karachi, PAK.

Anomalies pertaining to the coronary vasculature are rare and generally asymptomatic, however, they can pose life-threatening risks in the form of sudden cardiac arrests or myocardial ischemia. We present a rare anomaly of a supradominant left circumflex artery (LCX) and a rudimentary left anterior descending artery (LAD). The patient presented in our outpatient department (OPD) with complaints of occasional chest pain and dyspnea on exertion. Read More

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https://www.cureus.com/articles/13117-anomalous-supradominan
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http://dx.doi.org/10.7759/cureus.3189DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6199144PMC
August 2018
1 Read