11,547 results match your criteria Pharmacological Stress Testing

Intensity Dependent Effects of Interval Resistance Training on Myokines and Cardiovascular Risk Factors in Males With Obesity.

Front Endocrinol (Lausanne) 2022 10;13:895512. Epub 2022 Jun 10.

Univ Rennes, M2S (Laboratoire Mouvement, Sport, Santé), Rennes, France.

Objective: To determine the effects of different intensities of interval resistance training (IRT) protocols on the levels of select myokines (decorin, follistatin, myostatin, activin A, transforming growth factor beta-1 [TGF-β1]), and cardiometabolic and anthropometric measures in males with obesity.

Methods: Forty-four obese males (age: 27.5 ± 9. Read More

View Article and Full-Text PDF

Establishing Equivalent Aerobic Exercise Parameters Between Early-Stage Parkinson's Disease and Pink1 Knockout Rats.

J Parkinsons Dis 2022 Jun 23. Epub 2022 Jun 23.

Department of Pharmacology & Neuroscience, University of North Texas Health Science Center, Fort Worth, TX, USA.

Background: Rodent Parkinson's disease (PD) models are valuable to interrogate neurobiological mechanisms of exercise that mitigate motor impairment. Translating these mechanisms to human PD must account for physical capabilities of the patient.

Objective: To establish cardiovascular parameters as a common metric for cross-species translation of aerobic exercise impact. Read More

View Article and Full-Text PDF

Disruptions of circadian rhythms, sleep, and stress responses in zebrafish: New infrared-based activity monitoring assays for toxicity assessment.

Chemosphere 2022 Jun 21:135449. Epub 2022 Jun 21.

UCIBIO-REQUIMTE - Applied Molecular Biosciences Unit, Department of Drug Sciences, Pharmacology Lab, Faculty of Pharmacy, University of Porto, Portugal; Associate Laboratory i4HB - Institute for Health and Bioeconomy, Department of Drug Sciences, Pharmacology Lab, Faculty of Pharmacy, University of Porto, Portugal. Electronic address:

Behavioural disruptions are sensitive indicators of alterations to normal animal physiology and can be used for toxicity assessment. The small vertebrate zebrafish is a leading model organism for toxicological studies. The ability to continuously monitor the toxicity of drugs, pollutants, or environmental changes over several days in zebrafish can have high practical application. Read More

View Article and Full-Text PDF

Effects of Tai Chi on the quality of life, mental wellbeing, and physical function of adults with chronic diseases: Protocol for a single-blind, two-armed, randomised controlled trial.

PLoS One 2022 24;17(6):e0270212. Epub 2022 Jun 24.

School of Health and Biomedical Sciences, RMIT University, Bundoora, Australia.

Introduction: Quality of life (QoL), mental wellbeing, and physical function are often diminished among people with chronic disease. Tai Chi is a moderate form of exercise that may be effective in improving chronic disease management. This protocol paper outlines a trial to determine the therapeutic effects of a Tai Chi program on chronic disease management. Read More

View Article and Full-Text PDF

Mechanism-driven modeling of chemical hepatotoxicity using structural alerts and an in vitro screening assay.

J Hazard Mater 2022 Aug 20;436:129193. Epub 2022 May 20.

The Rutgers Center for Computational and Integrative Biology, Camden, NJ 08102, USA; Department of Chemistry, Rutgers University, Camden, NJ 08102, USA. Electronic address:

Traditional experimental approaches to evaluate hepatotoxicity are expensive and time-consuming. As an advanced framework of risk assessment, adverse outcome pathways (AOPs) describe the sequence of molecular and cellular events underlying chemical toxicities. We aimed to develop an AOP that can be used to predict hepatotoxicity by leveraging computational modeling and in vitro assays. Read More

View Article and Full-Text PDF

Aerobic Exercise Attenuates Kidney Injury, Improves Physical Performance, and Increases Antioxidant Defenses in Lungs of Adenine-Induced Chronic Kidney Disease Mice.

Inflammation 2022 Jun 21. Epub 2022 Jun 21.

Universidade Estadual de Santa Catarina (UDESC), Physical Therapy Graduate Program (PPG-Ft), Health and Sport Sciences Center (CEFID), Experimental Research Laboratory (LaPEx), R. Pascoal Simone, 358, Coqueiros, Florianópolis, ZIP Code: 88080-350, Santa Catarina, Brazil.

The association between chronic kidney disease (CKD) and pulmonary pathophysiological changes is well stablished. Nevertheless, the effects of aerobic exercise (AE) on lungs of CKD need further clarification. Thus, Swiss mice were divided in control, AE, CKD, and CKD + AE groups. Read More

View Article and Full-Text PDF

Intravenously transplanted mesenchymal stromal cells: a new endocrine reservoir for cardioprotection.

Stem Cell Res Ther 2022 Jun 17;13(1):253. Epub 2022 Jun 17.

Nankai University School of Medicine, 94 Weijin Road, Tianjin, 300071, China.

Background: Intravenous administration of mesenchymal stromal cells (MSCs) has an acknowledged competence of cardiac repair, despite a lack of systematic description of the underlying biological mechanisms. The lung, but not the heart, is the main trapped site for intravenously transplanted MSCs, which leaves a spatial gap between intravenously transplanted MSCs and the injured myocardium. How lung-trapped MSCs after intravenous transplantation rejuvenate the injured myocardium remains unknown. Read More

View Article and Full-Text PDF

Ginkgolic acid improves bleomycin-induced pulmonary fibrosis by inhibiting SMAD4 SUMOylation.

Oxid Med Cell Longev 2022 6;2022:8002566. Epub 2022 Jun 6.

Department of Pulmonary and Critical Care Medicine/ Key Laboratory of National Health Commission for the Diagnosis & Treatment of COPD, Inner Mongolia People's Hospital, Hohhot, Inner Mongolia, China.

Idiopathic pulmonary fibrosis (IPF) is a refractory chronic respiratory disease with progressively exacerbating symptoms and a high mortality rate. There are currently only two effective drugs for IPF; thus, there is an urgent need to develop new therapeutics. Previous experiments have shown that ginkgolic acid (GA), as a SUMO-1 inhibitor, exerted an inhibitory effect on cardiac fibrosis induced by myocardial infarction. Read More

View Article and Full-Text PDF

Treadmill Training Reduces Cerebral Ischemia-Reperfusion Injury by Inhibiting Ferroptosis through Activation of SLC7A11/GPX4.

Oxid Med Cell Longev 2022 6;2022:8693664. Epub 2022 Jun 6.

Department of Rehabilitation Medicine, The Affiliated Hospital of Qingdao University, China.

The mechanism by which exercise training attenuates cerebral ischemia/reperfusion (I/R) injury, especially in the regulation of iron level in neuronal damage, has not been systematically studied. Here, we showed that treadmill training inhibited ferroptosis after I/R injury in rats. Modified neurologic severity score (mNSS) test showed that the motor function, reflex, and balance abilities in the I/R injury rats after treadmill intervention were significantly improved. Read More

View Article and Full-Text PDF

Effect of a home-based resistance exercise program in elderly participants with osteoporosis: a randomized controlled trial.

Osteoporos Int 2022 Jun 15. Epub 2022 Jun 15.

Department of Nursing, Longhua Hospital Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, China.

The effectiveness of home-based resistance exercise in elder participants with osteoporosis remains unclear. This study demonstrates the beneficial effects of this mode of exercise on improving physical function, increasing confidence in exercise, and reducing fear of falling.

Introduction: This study aims to evaluate the effect of a home-based resistance exercise (HBRE) program versus control on physical function, exercise self-efficacy, falling efficacy, and health-related quality of life (HRQOL). Read More

View Article and Full-Text PDF

Ultrasonic disruption effects on the extraction efficiency, characterization, and bioactivities of polysaccharides from Panax notoginseng flower.

Carbohydr Polym 2022 Sep 27;291:119535. Epub 2022 Apr 27.

College of Chemistry, Changchun Normal University, Changchun 130032, China.

Ultrasonic disruption extraction (UDE) and heat reflux extraction (HRE) were used to extract polysaccharides (PNFPs) from Panax notoginseng flower, and the yield, physicochemical characteristics, structural characteristics, functional properties and biological activities were evaluated and compared. Results indicated that UDE changed the above properties of PNFPs. Compared with HRE (H-PNFPs), the yields, uronic acid contents, total phenolic content, total flavonoid content, water-solubility, water holding capacity, and oil holding capacity of the polysaccharides (U-PNFPs) extracted by UDE increased by 48. Read More

View Article and Full-Text PDF
September 2022

Variants in ASPH cause exertional heat illness and are associated with malignant hyperthermia susceptibility.

Nat Commun 2022 Jun 13;13(1):3403. Epub 2022 Jun 13.

Program for Genetics and Genome Biology, Hospital for Sick Children, Toronto, Ontario, Canada.

Exertional heat illness (EHI) and malignant hyperthermia (MH) are life threatening conditions associated with muscle breakdown in the setting of triggering factors including volatile anesthetics, exercise, and high environmental temperature. To identify new genetic variants that predispose to EHI and/or MH, we performed genomic sequencing on a cohort with EHI/MH and/or abnormal caffeine-halothane contracture test. In five individuals, we identified rare, pathogenic heterozygous variants in ASPH, a gene encoding junctin, a regulator of excitation-contraction coupling. Read More

View Article and Full-Text PDF

Repeated testing modulates chronic unpredictable mild stress effects in male rats.

Behav Brain Res 2022 Jun 10;432:113960. Epub 2022 Jun 10.

Department of Cognitive Neuroscience, Radboud University Medical Center, 6525 EN Nijmegen, the Netherlands.

Depression is a highly prevalent, debilitating mental disorder. Chronic unpredictable mild stress (CUMS) is the most widely applied model to study this affliction in rodents. While studies incorporating CUMS prior to an intervention often require long-lasting stress effects that persist after exposure is ceased, the longevity of these effects is rarely studied. Read More

View Article and Full-Text PDF

Effectiveness of Hoffman's Exercise in Postnatal Mothers With Grade 1 Inverted Nipples.

J Hum Lact 2022 Jun 13:8903344221102890. Epub 2022 Jun 13.

Siriraj Center of Research Excellence for Molecular Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Background: Breastfeeding provides perfect nutrition for infants. The inverted nipples in mothers make breastfeeding more challenging. Besides surgical approaches, non-pharmacological interventions are also gaining importance. Read More

View Article and Full-Text PDF

Metabolomic profiling and alleviation of oxidative stress of Huangjing Zanyu capsule treating oligoasthenospermia.

Transl Androl Urol 2022 May;11(5):659-674

National Institute of TCM Constitution and Preventive Medicine, Beijing University of Chinese Medicine, Beijing, China.

Background: The traditional Chinese medicine (TCM) patent medicine Huangjing Zanyu capsule (HJZY capsule) has achieved satisfactory clinical effects in the treatment of oligoasthenospermia (OAS). This study aimed to elucidate the impact of HJZY capsule on the reproductive system, focusing on oxidative stress and metabolism profiling during the intervention, to clarify the therapeutic mechanism of HJZY capsule in treating OAS.

Methods: Cyclophosphamide was used to establish OAS model rats. Read More

View Article and Full-Text PDF

Photoprotective and Antiaging Effects of a Standardized Red Orange ( (L.) Osbeck) Extract in Asian and Caucasian Subjects: A Randomized, Double-Blind, Controlled Study.

Nutrients 2022 May 27;14(11). Epub 2022 May 27.

Department of Drug and Health Science, University of Catania, Viale A. Doria, 95125 Catania, CT, Italy.

The increase in solar ultraviolet radiation (UVR) that reaches the Earth's surface should make us reflect on the need to develop new approaches in protecting the skin from UVR exposure. The present study aims to evaluate the photoprotective and antiaging efficacy of a red orange extract (100 mg/day) in both Asian and Caucasian subjects. A randomized, double-blind, controlled study was carried out in 110 Asian and Caucasian subjects. Read More

View Article and Full-Text PDF

Prophylactic Evidence of MSCs-Derived Exosomes in Doxorubicin/Trastuzumab-Induced Cardiotoxicity: Beyond Mechanistic Target of NRG-1/Erb Signaling Pathway.

Int J Mol Sci 2022 May 25;23(11). Epub 2022 May 25.

Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Benha University, Benha 13511, Egypt.

Trastuzumab (Trz) is a humanized monoclonal antibody targeting epidermal growth factor receptor 2 (HER2; ErbB2). The combined administration of Trz and doxorubicin (DOX) has shown potent anti-cancer efficacy; however, this regimen may be accompanied by severe cardiac toxicity. Mesenchymal stem cells (MSCs)-derived exosomes are nanosized vesicles that play a crucial role in cell-cell communication and have shown efficacy in the treatment of various diseases. Read More

View Article and Full-Text PDF

Animal Models of Exercise From Rodents to Pythons.

Circ Res 2022 Jun 9;130(12):1994-2014. Epub 2022 Jun 9.

Department of Medicine, Division of Cardiology, Cardiovascular Research Center, Corrigan Minehan Heart Center, Massachusetts General Hospital, Harvard Medical School, Boston (M.H.H., J.S.G., B.A., N.E.H., A.A.K., H.L., C.S., A.P.S., J.D.R., A.R.).

Acute and chronic animal models of exercise are commonly used in research. Acute exercise testing is used, often in combination with genetic, pharmacological, or other manipulations, to study the impact of these manipulations on the cardiovascular response to exercise and to detect impairments or improvements in cardiovascular function that may not be evident at rest. Chronic exercise conditioning models are used to study the cardiac phenotypic response to regular exercise training and as a platform for discovery of novel pathways mediating cardiovascular benefits conferred by exercise conditioning that could be exploited therapeutically. Read More

View Article and Full-Text PDF

Nanohydroxyapatite Hydrogel Can Promote the Proliferation and Migration of Chondrocytes and Better Repair Talar Articular Cartilage.

Comput Math Methods Med 2022 26;2022:8388473. Epub 2022 May 26.

Department of Foot and Ankle Surgery, Wuxi No.9 People's Hospital Affiliated to Soochow University, Wuxi, 214000 Jiangsu Province, China.

As an important load-bearing part of the body, joints are prone to articular cartilage degradation during exercise, resulting in joint pain, swelling, and deformity, which has an adverse impact on patients' life quality and social medical security. Therefore, this study aims to test an effective biopolymer scaffold in promoting the growth of chondrocytes in talus. Hydrogel (Gel)-nanohydroxyapatite (nHA) was invented as a new type of biopolymer scaffold for osteoarthritis treatment in this research. Read More

View Article and Full-Text PDF

The effect of treatment on insight in psychotic disorders - A systematic review and meta-analysis.

Schizophr Res 2022 Jun 2;244:126-133. Epub 2022 Jun 2.

Brighton and Sussex Medical School, University of Sussex, UK. Electronic address:

Background: For people with a psychotic disorder lack of insight can be detrimental on their condition and recovery. For this reason, insight has been considered as a target for therapy. We conducted a systematic review of the literature on pharmacological, psychological and other treatments to test the hypothesis that these interventions could improve insight. Read More

View Article and Full-Text PDF

Unexpected short- and long-term effects of chronic adolescent HU-210 exposure on emotional behavior.

Neuropharmacology 2022 08 2;214:109155. Epub 2022 Jun 2.

Instituto de Farmacologia e Neurociências, Faculdade de Medicina, Universidade de Lisboa, 1649-028, Lisboa, Portugal; Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, 1649-028, Lisboa, Portugal. Electronic address:

Chronic adolescent cannabinoid receptor agonist exposure has been shown to lead to persistent increases in depressive-like behaviors. This has been a key obstacle to the development of cannabinoid-based therapeutics. However, most of the published work has been performed with only three compounds, namely Δ9-tetrahydrocannabinol, CP55,940 and WIN55,212-2. Read More

View Article and Full-Text PDF

The current state of clinical mycology in Africa: a European Confederation of Medical Mycology and International Society for Human and Animal Mycology survey.

Lancet Microbe 2022 Jun 18;3(6):e464-e470. Epub 2022 Jan 18.

Post-graduation Programme in Pathology, Federal University of Health Sciences of Porto Alegre, Porto Alegre, Brazil; Molecular Biology Laboratory, Santa Casa de Misericordia de Porto Alegre, Porto Alegre, Brazil. Electronic address:

Africa, although not unique in this context, is a favourable environment for fungal infections, given the high burden of risk factors. An online survey was developed asking about laboratory infrastructure and antifungal drug availability. We received 40 responses (24·4% response rate) of 164 researchers contacted from 21 African countries. Read More

View Article and Full-Text PDF

Effects of Ubiquinol and/or D-ribose in Patients With Heart Failure With Preserved Ejection Fraction.

Am J Cardiol 2022 Aug 27;176:79-88. Epub 2022 May 27.

University of Kansas Medical Center, School of Nursing, Kansas City, Kansas.

Patients with heart failure with preserved ejection fraction (HFpEF) have few pharmacologic therapies, and it is not known if supplementing with ubiquinol and/or d-ribose could improve outcomes. The overall objective of this study was to determine if ubiquinol and/or d-ribose would reduce the symptoms and improve cardiac performance in patients with HFpEF. This was a phase 2 randomized, double-blind, placebo-controlled trial of 216 patients with HFpEF who were ≥ 50 years old with a left ventricular ejection fraction (EF) ≥ 50%. Read More

View Article and Full-Text PDF

The relationship between the severity of perimenstrual symptoms and a regular exercise habit in Japanese young women: a cross-sectional online survey.

BMC Womens Health 2022 05 28;22(1):200. Epub 2022 May 28.

Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8553, Japan.

Background: Experiencing perimenstrual symptoms is a major health concern for young women. Women in the reproductive age experience menstruation about once a month, and many experience perimenstrual symptoms. Drug therapies such as painkillers (commonly used) and hormonal medications help to achieve symptomatic relief from perimenstrual symptoms. Read More

View Article and Full-Text PDF

Prophylactic Zinc Administration Combined with Swimming Exercise Prevents Cognitive-Emotional Disturbances and Tissue Injury following a Transient Hypoxic-Ischemic Insult in the Rat.

Behav Neurol 2022 20;2022:5388944. Epub 2022 May 20.

Facultad de Ciencias Químicas, Benemérita, Universidad Autónoma de Puebla, 14 Sur y Av. San Claudio, 72570 Puebla Pue, Mexico.

Exercise performance and zinc administration individually yield a protective effect on various neurodegenerative models, including ischemic brain injury. Therefore, this work was aimed at evaluating the combined effect of subacute prophylactic zinc administration and swimming exercise in a transient cerebral ischemia model. The prophylactic zinc administration (2. Read More

View Article and Full-Text PDF

Long-lasting and sex-dependent effects of postweaning swimming exercise on social dominance in adult mice.

Neuroscience 2022 May 27. Epub 2022 May 27.

Neuroscience Research Center, Institute of Medical and Health Science of HeBMU, Hebei Medical University, Shijiazhuang 050017, China; Hebei Key Laboratory of Neurophysiology, Hebei Medicinal University, Shijiazhuang 050017, China; Research Unit of Digestive Tract Microecosystem Pharmacology and Toxicology, Chinese Academy of Medical Sciences, Shijiazhuang 050017, China. Electronic address:

Increasing evidence has shown that early life events exert long-lasting effects on brain function and mental diseases. Exercise has been proven to have many positive effects on behaviors, such as reducing anxiety- and depression-like behaviors and alleviating cognitive impairment. However, the long-lasting and even short-term effects of regular swimming exercise on social dominance remain unclear. Read More

View Article and Full-Text PDF

Impact of Atorvastatin on Skeletal Muscle Mitochondrial Activity, Locomotion and Axonal Excitability-Evidence from Mice.

Int J Mol Sci 2022 May 12;23(10). Epub 2022 May 12.

Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, 20133 Milan, Italy.

The cardiovascular benefit of statins is well established. However, only 20% of high-risk patients remain adequately adherent after 5 years of treatment. Among reasons for discontinuation, statin associated-muscle pain symptoms are the most prevalent. Read More

View Article and Full-Text PDF

Trends and Determinants in Uptake of Cervical Cancer Screening in Spain: An Analysis of National Surveys from 2017 and 2020.

Cancers (Basel) 2022 May 18;14(10). Epub 2022 May 18.

Department of Preventive Medicine and Public Health, Faculty of Medicine, University of Seville, Avda. Doctor Fedriani, S/N, 41009 Seville, Spain.

Cervical cancer rates have declined in industrialized nations as a result of cytology screening programs. However, there are still sizeable differences in screening adherence in Spain. This study aimed to identify the prevalence of cervical cancer screening among women in Spain, to analyze trends in that prevalence from 2017 and 2020 and to identify socio-demographic, health, and lifestyle factors related with adherence to this screening test. Read More

View Article and Full-Text PDF

MitoQ supplementation augments acute exercise-induced increases in muscle PGC1α mRNA and improves training-induced increases in peak power independent of mitochondrial content and function in untrained middle-aged men.

Redox Biol 2022 07 20;53:102341. Epub 2022 May 20.

Discipline of Nutrition, School of Medical Sciences, University of Auckland, Auckland, New Zealand; Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland, Auckland, New Zealand.

The role of mitochondrial ROS in signalling muscle adaptations to exercise training has not been explored in detail. We investigated the effect of supplementation with the mitochondria-targeted antioxidant MitoQ on a) the skeletal muscle mitochondrial and antioxidant gene transcriptional response to acute high-intensity exercise and b) skeletal muscle mitochondrial content and function following exercise training. In a randomised, double-blind, placebo-controlled, parallel design study, 23 untrained men (age: 44 ± 7 years, VO: 39. Read More

View Article and Full-Text PDF

Effects of musk volatile compounds on attenuated nerve injury and improving post-cerebral ischemic exercise functions.

Curr Pharm Des 2022 May 26. Epub 2022 May 26.

School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 611137, People's Republic of China.

Background: Reperfusion Injury Acute ischemic stroke is increasing in people recently and Musk, as a commonly used Traditional Chinese Medicine (TCM), has been suggested as a potential agent against acute ischemic stroke, but the efficacies and underlying mechanisms of it remain unknown.

Objective: This study was aimed to tested the hypotheses that volatile compounds of musk could attenuate nerve injury and identify the bioactive compounds and potential mechanisms of Musk.

Method: Transient middle cerebral artery occlusion (MCAO) model in vivo in Sprague-Dawley rats (SD rats) was used to test this hypothesis. Read More

View Article and Full-Text PDF