9,813 results match your criteria Pharmacologic Stress Testing


Comparative measurement properties of constant work rate cycling and the endurance shuttle walking test in COPD: the TORRACTO clinical trial.

Ther Adv Respir Dis 2020 Jan-Dec;14:1753466620926858

Rehabilitation Clinical Trial Centre, Los Angeles Biomedical Research Institute at Harbour-UCLA Medical Centre, Torrance, CA, USA.

Background: Exercise tolerance is an important endpoint in chronic obstructive pulmonary disease (COPD) clinical trials. Little is known about the comparative measurement properties of constant work rate cycle ergometry (CWRCE) and the endurance shuttle walking test (ESWT). The objective of this sub-analysis of the TORRACTO study was to directly compare the endurance measurement properties of CWRCE and ESWT in patients with COPD in a multicentre, multinational setting. Read More

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http://dx.doi.org/10.1177/1753466620926858DOI Listing

Maternal presence or absence alters nociceptive responding and cortical anandamide levels in juvenile female rats.

Behav Brain Res 2020 May 29:112712. Epub 2020 May 29.

Centre for Pain Research, National University of Ireland Galway, Ireland; Physiology, School of Medicine, National University of Ireland Galway, Ireland; Galway Neuroscience Centre, National University of Ireland Galway, Ireland. Electronic address:

The influence of parental support on child pain experiences is well recognised. Accordingly, animal studies have revealed both short- and long-term effects of early life stress on nociceptive responding and neural substrates such as endocannabinoids. The endocannabinoid system plays an important role in mediating and modulating stress, social interaction, and nociception. Read More

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http://dx.doi.org/10.1016/j.bbr.2020.112712DOI Listing

Effect of a lactate-guided conditioning program on heart rate variability obtained using 24-Holter electrocardiography in Beagle dogs.

PLoS One 2020 1;15(6):e0233264. Epub 2020 Jun 1.

Department of Animal Morphology and Physiology, Laboratory of Pharmacology and Equine Exercise Physiology (LAFEQ), School of Agricultural and Veterinarian Sciences (FCAV), São Paulo State University (UNESP), Jaboticabal, SP, Brazil.

The dogs' responses to training exercise are seldom monitored using physiological variables, and cardiac autonomic regulation (CAR) is a relevant determinant of endurance-training adaptation. There are studies in the literature establishing that regular exercise could interfere with CAR in dogs, measured by heart rate and vagal-derived indexes of heart-rate-variability (HRV). However, few studies were found using a prescribed training program based on the lactate threshold (LT) to determine HRV by a 24-h Holter analysis. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0233264PLOS

Utility of imaging modalities in coronary lesions with borderline fractional flow reserve.

Cardiovasc Revasc Med 2020 Apr 15. Epub 2020 Apr 15.

Division of Cardiovascular Disease, Einstein Medical Center, Philadelphia, PA 19141, United States of America. Electronic address:

Background: Coronary intervention is routinely deferred in intermediate lesions with fractional flow reserve (FFR) ≥ 0.80. Patients with borderline FFR (0. Read More

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http://dx.doi.org/10.1016/j.carrev.2020.04.018DOI Listing

Farnesoid X receptor-mediated cytoplasmic translocation of CRTC2 disrupts CREB-BDNF signaling in hippocampal CA1 and leads to the development of depression-like behaviors in mice.

Int J Neuropsychopharmacol 2020 May 26. Epub 2020 May 26.

Department of Pharmacology, School of Pharmacy, Nantong University, Nantong, Jiangsu, China.

Background: We recently identified neuronal expression of farnesoid X receptor (FXR), a bile acid receptor known to impair autophagy by inhibiting cyclic adenosine monophosphate response element-binding protein (CREB), a protein whose under-functioning is linked to neuroplasticity and depression. In this study, we hypothesize that FXR may mediate depression via a CREB-dependent mechanism.

Methods: Depression was induced in male C57BL6/J mice via chronic unpredictable stress (CUS). Read More

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http://dx.doi.org/10.1093/ijnp/pyaa039DOI Listing

Effect of exercise on telomere length and telomere proteins expression in mdx mice.

Mol Cell Biochem 2020 May 23. Epub 2020 May 23.

Nemo Sud Clinical Centre for Neuromuscular Disorders, Messina University Hospital, Via Consolare Valeria 1, 98125, Messina, Italy.

In Duchenne muscular dystrophy (DMD), telomere shortening has been postulated to contribute to the failure of regenerative activity promoting the premature senescence of satellite cells. The aim of the present study was to investigate the telomere length and the expression of telomeric repeat-binding factor-1 (TRF1), poly (ADP-ribose) polymerase-1 (PARP1) and mouse telomerase reverse transcriptase (MTERT) in gastrocnemius, tibialis anterior and diaphragm muscles of the murine model of DMD, the mdx mouse and whether a chronic protocol of forced exercise impacts on them. Our results confirmed a telomere shortening in mdx muscles, more evident in the diaphragm, in which exercise induced a greater shortening than in wild-type mice. Read More

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http://dx.doi.org/10.1007/s11010-020-03761-3DOI Listing

Antidepressant-like and memory-enhancing effects of the N-type calcium channel blocker ziconotide in rats.

Behav Brain Res 2020 May 16;390:112647. Epub 2020 May 16.

Department of Pharmacology, Research Center of Physiology, School of Medicine, Semnan University of Medical Sciences, Semnan, Iran.

The lack of oral or injectable formulations of ziconotide (ω-conotoxin peptide), a novel analgesic agent, limits research on potential neurobehavioral protective properties of this substance, including antidepressant-like effects. Here we expose rats to a stress paradigm that induces depression and memory impairment to assess the effects of ziconotide treatment. Ziconotide was administered intracerebroventricular (i. Read More

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http://dx.doi.org/10.1016/j.bbr.2020.112647DOI Listing

Exercise training reverses cancer-induced oxidative stress and decrease in muscle COPS2/TRIP15/ALIEN.

Mol Metab 2020 May 11:101012. Epub 2020 May 11.

School of Physical Education and Sport, University of Sao Paulo, Sao Paulo, Brazil. Electronic address:

Objective: We tested the hypothesis that exercise training would attenuate metabolic impairment in a model of severe cancer cachexia and we explored the mechanisms underlying those effects.

Methods And Results: Exercise training improved running capacity, prolonged lifespan, reduced oxidative stress, and normalized muscle mass and contractile function in tumor-bearing rats. An unbiased proteomic screening revealed COP9 signalosome complex subunit 2 (COPS2) as one of the most downregulated proteins in skeletal muscle at the early stage of cancer cachexia. Read More

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http://dx.doi.org/10.1016/j.molmet.2020.101012DOI Listing

Aerobic exercise improves cognition and cerebrovascular regulation in older adults.

Neurology 2020 May 13;94(21):e2245-e2257. Epub 2020 May 13.

From the Department of Physiology and Pharmacology (V.G., L.L.D., A.V.T., G.A.E., M.J.P.), Hotchkiss Brain Institute (V.G., L.L.D., A.V.T., R.S.L., M.D.H., D.B.H., M.J.P.), Division of Geriatric Medicine (D.B.H.), Department of Medicine, Department of Clinical Neurosciences (V.G., L.L.D., A.V.T., M.D.H., D.B.H., M.J.P.), Libin Cardiovascular Institute of Alberta (T.J.A., M.J.P.), O'Brien Institute for Public Health (V.G., D.B.H., M.J.P.), Department of Cardiac Sciences (T.J.A.), Libin Cardiovascular Institute of Alberta, and Department of Community Health Sciences (M.D.H.), Cumming School of Medicine, Faculty of Kinesiology (M.J.P.), and Department of Psychology (R.S.L.), University of Calgary; Psychology Service (R.S.L.), Alberta Health Service, Foothills Medical Centre, Calgary; Department of Psychiatry (G.A.E.), Faculty of Medicine, and Department of Psychology and Neuroscience (G.A.E.), Faculty of Science, Dalhousie University, Halifax, Nova Scotia; and Program for Pregnancy and Postpartum Health, Physical Activity and Diabetes Laboratory (M.H.D.), Faculty of Kinesiology, Sport, and Recreation, Women and Children's Health Research Institute, Alberta Diabetes Institute, University of Alberta, Edmonton, Canada.

Objective: To test the hypothesis that aerobic exercise is associated with improvements in cognition and cerebrovascular regulation, we enrolled 206 healthy low-active middle-aged and older adults (mean ± SD age 65.9 ± 6.4 years) in a supervised 6-month aerobic exercise intervention and assessed them before and after the intervention. Read More

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http://dx.doi.org/10.1212/WNL.0000000000009478DOI Listing

Modulation of fear behavior and neuroimmune alterations in house dust mite exposed A/J mice, a model of severe asthma.

Brain Behav Immun 2020 May 4. Epub 2020 May 4.

Dept. of Pharmacology & Systems Physiology, University of Cincinnati, Cincinnati OH, 45220; Neuroscience Graduate Program, University of Cincinnati, Cincinnati OH, 45220; VA Medical Center, Cincinnati, OH, 45220. Electronic address:

Fear-associated conditions such as posttraumatic stress disorder (PTSD) and panic disorder (PD) are highly prevalent. There is considerable interest in understanding contributory risk and vulnerability factors. Accumulating evidence suggests that chronically elevated inflammatory load may be a potential risk factor for these disorders. Read More

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http://dx.doi.org/10.1016/j.bbi.2020.04.084DOI Listing

Effect of nocturnal melatonin intake on cellular damage and recovery from repeated sprint performance during an intensive training schedule.

Chronobiol Int 2020 May 7:1-13. Epub 2020 May 7.

Interdisciplinary Laboratory in Neurosciences, Physiology and Psychology: Physical Activity, Health and Learning (LINP2-APSA), UPL, Paris Nanterre University, UFR STAPS, Nanterre, France.

An optimal recovery between training sessions is of similar if not greater importance as the training content and program of the training, itself. One of the most used strategies for improving recovery is the ingestion of supplements. The present study aimed to evaluate the effect of 5 mg oral melatonin supplementation on the recovery from repeated sprint (RSA) of performance and biochemical responses (. Read More

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http://dx.doi.org/10.1080/07420528.2020.1746797DOI Listing

Comparative efficacy of empagliflozin and drugs of baseline therapy in post-infarct heart failure in normoglycemic rats.

Naunyn Schmiedebergs Arch Pharmacol 2020 May 6. Epub 2020 May 6.

Pavlov First Saint Petersburg State Medical University, Saint Petersburg, Russia.

The study aimed to investigate the effects of the sodium-glucose co-transporter 2 (SGLT2) inhibitor empagliflozin on chronic heart failure (HF) in normoglycemic rats. The effects of empagliflozin were compared with the standard medications for HF, e.g. Read More

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http://dx.doi.org/10.1007/s00210-020-01873-7DOI Listing

En Balance: The Contribution of Physical Activity to the Efficacy of Spanish Diabetes Education of Hispanic Americans with Type 2 Diabetes.

J Diabetes Res 2020 19;2020:4826704. Epub 2020 Apr 19.

Center for Health Disparities and Molecular Medicine, Loma Linda University School of Medicine, 11085 Campus Street, Loma Linda, CA 92350, USA.

Purpose: , a culturally sensitive diabetes education program, improves glycemic control in Hispanics with type 2 diabetes. The program emphasized diet, physical activity, and other factors important for glycemic control. However, the individual contributions of these education factors are unclear. Read More

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http://dx.doi.org/10.1155/2020/4826704DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191357PMC

Oral nitrate supplementation to enhance pulmonary rehabilitation in COPD: ON-EPIC a multicentre, double-blind, placebo-controlled, randomised parallel group study.

Thorax 2020 May 6. Epub 2020 May 6.

National Heart and Lung Institute, Royal Brompton Campus, Imperial College London, London, UK

Rationale: Dietary nitrate supplementation has been proposed as a strategy to improve exercise performance, both in healthy individuals and in people with COPD. We aimed to assess whether it could enhance the effect of pulmonary rehabilitation (PR) in COPD.

Methods: This double-blind, placebo-controlled, parallel group, randomised controlled study performed at four UK centres, enrolled adults with Global Initiative for Chronic Obstructive Lung Disease grade II-IV COPD and Medical Research Council dyspnoea score 3-5 or functional limitation to undertake a twice weekly 8-week PR programme. Read More

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http://dx.doi.org/10.1136/thoraxjnl-2019-214278DOI Listing

Gene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci.

Authors:
Lisa de Las Fuentes Yun Ju Sung Raymond Noordam Thomas Winkler Mary F Feitosa Karen Schwander Amy R Bentley Michael R Brown Xiuqing Guo Alisa Manning Daniel I Chasman Hugues Aschard Traci M Bartz Lawrence F Bielak Archie Campbell Ching-Yu Cheng Rajkumar Dorajoo Fernando P Hartwig A R V R Horimoto Changwei Li Ruifang Li-Gao Yongmei Liu Jonathan Marten Solomon K Musani Ioanna Ntalla Tuomo Rankinen Melissa Richard Xueling Sim Albert V Smith Salman M Tajuddin Bamidele O Tayo Dina Vojinovic Helen R Warren Deng Xuan Maris Alver Mathilde Boissel Jin-Fang Chai Xu Chen Kaare Christensen Jasmin Divers Evangelos Evangelou Chuan Gao Giorgia Girotto Sarah E Harris Meian He Fang-Chi Hsu Brigitte Kühnel Federica Laguzzi Xiaoyin Li Leo-Pekka Lyytikäinen Ilja M Nolte Alaitz Poveda Rainer Rauramaa Muhammad Riaz Rico Rueedi Xiao-Ou Shu Harold Snieder Tamar Sofer Fumihiko Takeuchi Niek Verweij Erin B Ware Stefan Weiss Lisa R Yanek Najaf Amin Dan E Arking Donna K Arnett Sven Bergmann Eric Boerwinkle Jennifer A Brody Ulrich Broeckel Marco Brumat Gregory Burke Claudia P Cabrera Mickaël Canouil Miao Li Chee Yii-Der Ida Chen Massimiliano Cocca John Connell H Janaka de Silva Paul S de Vries Gudny Eiriksdottir Jessica D Faul Virginia Fisher Terrence Forrester Ervin F Fox Yechiel Friedlander He Gao Bruna Gigante Franco Giulianini Chi Charles Gu Dongfeng Gu Tamara B Harris Jiang He Sami Heikkinen Chew-Kiat Heng Steven Hunt M Arfan Ikram Marguerite R Irvin Mika Kähönen Maryam Kavousi Chiea Chuen Khor Tuomas O Kilpeläinen Woon-Puay Koh Pirjo Komulainen Aldi T Kraja J E Krieger Carl D Langefeld Yize Li Jingjing Liang David C M Liewald Ching-Ti Liu Jianjun Liu Kurt K Lohman Reedik Mägi Colin A McKenzie Thomas Meitinger Andres Metspalu Yuri Milaneschi Lili Milani Dennis O Mook-Kanamori Mike A Nalls Christopher P Nelson Jill M Norris Jeff O'Connell Adesola Ogunniyi Sandosh Padmanabhan Nicholette D Palmer Nancy L Pedersen Thomas Perls Annette Peters Astrid Petersmann Patricia A Peyser Ozren Polasek David J Porteous Leslie J Raffel Treva K Rice Jerome I Rotter Igor Rudan Oscar-Leonel Rueda-Ochoa Charumathi Sabanayagam Babatunde L Salako Pamela J Schreiner James M Shikany Stephen S Sidney Mario Sims Colleen M Sitlani Jennifer A Smith John M Starr Konstantin Strauch Morris A Swertz Alexander Teumer Yih Chung Tham André G Uitterlinden Dhananjay Vaidya M Yldau van der Ende Melanie Waldenberger Lihua Wang Ya-Xing Wang Wen-Bin Wei David R Weir Wanqing Wen Jie Yao Bing Yu Caizheng Yu Jian-Min Yuan Wei Zhao Alan B Zonderman Diane M Becker Donald W Bowden Ian J Deary Marcus Dörr Tõnu Esko Barry I Freedman Philippe Froguel Paolo Gasparini Christian Gieger Jost Bruno Jonas Candace M Kammerer Norihiro Kato Timo A Lakka Karin Leander Terho Lehtimäki Patrik K E Magnusson Pedro Marques-Vidal Brenda W J H Penninx Nilesh J Samani Pim van der Harst Lynne E Wagenknecht Tangchun Wu Wei Zheng Xiaofeng Zhu Claude Bouchard Richard S Cooper Adolfo Correa Michele K Evans Vilmundur Gudnason Caroline Hayward Bernardo L Horta Tanika N Kelly Stephen B Kritchevsky Daniel Levy Walter R Palmas A C Pereira Michael M Province Bruce M Psaty Paul M Ridker Charles N Rotimi E Shyong Tai Rob M van Dam Cornelia M van Duijn Tien Yin Wong Kenneth Rice W James Gauderman Alanna C Morrison Kari E North Sharon L R Kardia Mark J Caulfield Paul Elliott Patricia B Munroe Paul W Franks Dabeeru C Rao Myriam Fornage

Mol Psychiatry 2020 May 5. Epub 2020 May 5.

Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, 70808, USA.

Educational attainment is widely used as a surrogate for socioeconomic status (SES). Low SES is a risk factor for hypertension and high blood pressure (BP). To identify novel BP loci, we performed multi-ancestry meta-analyses accounting for gene-educational attainment interactions using two variables, "Some College" (yes/no) and "Graduated College" (yes/no). Read More

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http://dx.doi.org/10.1038/s41380-020-0719-3DOI Listing
May 2020
14.496 Impact Factor

Vietnamese version of the coronary artery disease education questionnaire-Short version: Translation, adaptation and validation.

J Clin Pharm Ther 2020 Apr 30. Epub 2020 Apr 30.

Groningen Research Institute of Pharmacy, University of Groningen, Groningen, The Netherlands.

What Is Known And Objective: Coronary artery disease (CAD) is the leading cause of mortality worldwide. Patient education is an essential part of cardiac patients' care targeting self-management behaviour to reduce risk factors and subsequent events. There has been no Vietnamese questionnaire to assess patient's knowledge about CAD; therefore, the purpose of this study was to translate, cross-culturally adapt and validate the Coronary Artery Disease Education Questionnaire-Short Version (CADE-Q SV) for use in Vietnam. Read More

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http://dx.doi.org/10.1111/jcpt.13145DOI Listing
April 2020
1.533 Impact Factor

Mindfulness with paced breathing reduces blood pressure.

Med Hypotheses 2020 Apr 22;142:109780. Epub 2020 Apr 22.

Charles E. Schmidt College of Medicine, Florida Atlantic University, United States.

Elevated blood pressure (BP) is a major avoidable cause of premature morbidity and mortality in the United States (US) and worldwide, due primarily to increased risks of stroke as well as myocardial infarction. While there are therapeutic lifestyle changes and adjunctive pharmacologic medications of proven benefit, recent interest has increasingly focused on Complementary and Alternative Medicine, in particular, Mind-Body Interventions. With respect to BP, it is tempting to speculate that mindfulness with paced breathing will have beneficial effects in the short run that may translate into lowered risks of stroke in the long run. Read More

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http://dx.doi.org/10.1016/j.mehy.2020.109780DOI Listing

Noninvasive Leg-Positive Pressure Stress Echocardiography Reveals Preload Reserve in Adult Patients after Complete Repair of Tetralogy of Fallot.

J Am Soc Echocardiogr 2020 Apr 23. Epub 2020 Apr 23.

Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.

Background: Long-term sequelae such as right ventricular dysfunction and reduced hemodynamic reserve are the main determinants of cardiovascular outcomes after repair of tetralogy of Fallot (TOF). Echocardiographic parameters at rest offer only partial information on impaired hemodynamics in these patients, and data during stress testing are lacking. The leg-positive pressure (LPP) maneuver has recently been reported to be able to apply acute preload stress. Read More

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http://dx.doi.org/10.1016/j.echo.2020.02.012DOI Listing

The Validity of the YMCA 3-Minute Step Test for Estimating Maximal Oxygen Uptake in Healthy Korean and Vietnamese Adults.

J Lifestyle Med 2020 Jan;10(1):21-29

Clinical Trial Center for Functional Foods, Chonbuk National University Hospital, Jeonju, Korea.

Background: Cardiorespiratory fitness (CRF) is a fundamental component of physical fitness. While maximal oxygen uptake (VOmax) is the gold standard for quantifying CRF, standard maximal exercise tests using direct measurements VOmax are dependent on the availability of laboratory equipment, and thereby expensive and time consuming. Recently, an equation was formulated to indirectly estimate VOmax using the YMCA 3-minute step test. Read More

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http://dx.doi.org/10.15280/jlm.2020.10.1.21DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7171059PMC
January 2020

The Combination Effects of Resveratrol and Swimming HIIT Exercise on Novel Object Recognition and Open-field Tasks in Aged Rats.

Exp Aging Res 2020 Apr 23:1-23. Epub 2020 Apr 23.

Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran.

: Resveratrol, a natural polyphenol abundant in grapes and red wine, has been reported to exert numerous beneficial health effects in the body. High-Intensity Interval Exercise (HIIT) is a form of interval training that provides improved athletic capacity and has a protective effect on health. The purpose of this study was to investigate the interactive effects of swimming HIIT and Resveratrol supplementation on behavioral function in Novel object recognition and open-field tests in aged rats. Read More

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http://dx.doi.org/10.1080/0361073X.2020.1754015DOI Listing

Febuxostat does not delay progression of carotid atherosclerosis in patients with asymptomatic hyperuricemia: A randomized, controlled trial.

PLoS Med 2020 Apr 22;17(4):e1003095. Epub 2020 Apr 22.

Department of Cardiovascular Medicine, Saga University, Saga, Japan.

Background: An elevated level of serum uric acid (SUA) is associated with an increased risk of cardiovascular disease. Pharmacological intervention with urate-lowering agents, such as the conventional purine analogue xanthine oxidase (XO) inhibitor, allopurinol, has been used widely for a long period of time in clinical practice to reduce SUA levels. Febuxostat, a novel non-purine selective inhibitor of XO, has higher potency for inhibition of XO activity and greater urate-lowering efficacy than conventional allopurinol. Read More

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http://dx.doi.org/10.1371/journal.pmed.1003095DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7176100PMC

Effects of alternate nostril breathing exercise on respiratory functions in healthy young adults leading stressful lifestyle.

J Popul Ther Clin Pharmacol 2020 Mar 19;27(1):e104-e114. Epub 2020 Mar 19.

Unit of Pharmacology, Faculty of Medicine and Defence Health, Universiti Pertahanan Nasional Malaysia (National Defence University of Malaysia), Kuala Lumpur, Malaysia.

Alternate nostril breathing (ANB) is one of the best and easiest breathing exercises (pranayama) of yoga that are good for health and physical fitness. ANB exercise has beneficial and therapeutic effects on respiratory function in both normal as well as diseased humans. This study was conducted with the objective of assessing the physiological effects of short-term ANB exercise on respiratory function in healthy adult individuals leading a stressful life. Read More

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http://dx.doi.org/10.15586/jptcp.v27i1.668DOI Listing

Iron Status in Elderly Women Impacts Myostatin, Adiponectin and Osteocalcin Levels Induced by Nordic Walking Training.

Nutrients 2020 Apr 17;12(4). Epub 2020 Apr 17.

Department of Bioenergetics and Physiology of Exercise, Medical University of Gdansk, 80-210 Gdansk, Poland.

Impaired iron metabolism is associated with increased risk of many morbidities. Exercise was shown to have a beneficial role; however, the mechanism is not well understood. The purpose of this study was to assess the relationship between exerkines and iron metabolism in elderly women before and after 12 weeks of Nordic Walking (NW) training. Read More

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http://dx.doi.org/10.3390/nu12041129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7231223PMC

The salmeterol anomaly and the need for a urine threshold.

Drug Test Anal 2020 Apr 20. Epub 2020 Apr 20.

Section of Integrative Physiology, Department of Nutrition Exercise and Sports, University of Copenhagen, Denmark.

Salmeterol is a long acting beta2-agonist (LABA) widely used for treatment of airways disease. There is evidence that beta2-agonists, including salmeterol, have the potential for performance enhancing effects when delivered at supratherapeutic doses. For this reason, all beta2-agonists are currently on the Prohibited List issued by the World Anti-Doping Agency (WADA) regardless of dosing route with some exemptions for inhaled salbutamol, formoterol, and salmeterol when used at therapeutic inhaled doses. Read More

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http://dx.doi.org/10.1002/dta.2810DOI Listing

Assessment and Management of Urinary Dysfunction in 187 Patients with Parkinson's Disease.

J Parkinsons Dis 2020 Apr 13. Epub 2020 Apr 13.

Department of Urology, Xuanwu Hospital Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing, China.

Background: Urinary dysfunction is common in Parkinson's disease (PD) patients and management options are limited.

Objective: This study aimed to explore the management of urinary dysfunction by researching the special needs of PD patients.

Methods: PD patients with urinary dysfunction who underwent urodynamic testing were recruited from a single center from October 2013 to February 2019. Read More

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http://dx.doi.org/10.3233/JPD-191806DOI Listing

[The efficacy of metabolic treatment in the early recovery period of patients with ischemic stroke].

Zh Nevrol Psikhiatr Im S S Korsakova 2020 ;120(3. Vyp. 2):49-53

Central City Clinical Hospital #6, Yekaterinburg, Russia.

Aim: To evaluate the efficacy of including cytoflavin in rehabilitation measures in the early recovery period of patients with ischemic stroke.

Material And Methods: Results of rehabilitation measures of 100 patients (50 women and 50 men, aged 18 to 85 years) in the early recovery period of ischemic stroke were analyzed. Psychological testing included NIHSS, MMSE, Rankin scale, Rivermead mobility index, exercise tolerance test. Read More

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http://dx.doi.org/10.17116/jnevro202012003249DOI Listing

Overlapping mechanism of the induction of genomic damage by insulin and adrenaline in human promyelocytic HL-60 cells.

Toxicol In Vitro 2020 Aug 17;66:104867. Epub 2020 Apr 17.

Institute of Pharmacology and Toxicology, University of Wuerzburg, Wuerzburg, Germany. Electronic address:

Endogenous hormones systemically regulate the growth and metabolism and some prior studies have shown that their imbalance can have a potential to induce genomic damage in in vitro and animal models. Some conditions that are associated with elevated levels of endogenous hormones are hyperinsulinemia and intense exercise-induced stress causing increased adrenaline. In this study we test whether these two hormones, could cause an additive increase in genomic damage and whether they have an overlapping mechanism of action. Read More

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http://dx.doi.org/10.1016/j.tiv.2020.104867DOI Listing

The neuroprotective effect of Riparin IV on oxidative stress and neuroinflammation related to chronic stress-induced cognitive impairment.

Horm Behav 2020 Apr 27;122:104758. Epub 2020 Apr 27.

Neuropharmacology Laboratory, Drug Research and Development Center, Department of Physiology and Pharmacology, School of Medicine, Federal University of Ceará, Fortaleza, Ceará, Brazil. Electronic address:

Background: Cognitive impairment is identified as one of the diagnostic criteria for major depressive disorder and can extensively affect the quality of life of patients. Based on these findings, this study aimed to investigate the possible effects of Riparin IV (Rip IV) on cognitive impairment induced by chronic administration of corticosterone in mice.

Methods: Female Swiss mice were divided into four groups: control (Control), corticosterone (Cort), Riparin IV (Cort + Rip IV), and Fluvoxamine (Cort + Flu). Read More

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http://dx.doi.org/10.1016/j.yhbeh.2020.104758DOI Listing

The Effect of Pelvic Floor Muscle Strengthening Exercise on Urinary Incontinence and Quality of Life in Patients after Prostatectomy: a Randomized Clinical Trial.

J Caring Sci 2020 Mar 1;9(1):33-38. Epub 2020 Mar 1.

Department of Nursing, Nursing and Midwifery Faculty, Tehran University of Medical Sciences, Tehran, Iran.

Urinary incontinence is a common problem after Prostatectomy that affects patients' life. Nurses can assist patients in improving urinary problems. This study aimed to assess the effects of pelvic floor muscle exercises on urinary incontinence and the quality of life in patients after Prostatectomy. Read More

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http://dx.doi.org/10.34172/jcs.2020.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7146723PMC

A Pharmacologic "Stress Test" for Assessing Select Antioxidant Defenses in Patients with CKD.

Clin J Am Soc Nephrol 2020 May 14;15(5):633-642. Epub 2020 Apr 14.

Renibus Therapeutics, Southlake, Texas.

Background And Objectives: Oxidative stress is a hallmark and mediator of CKD. Diminished antioxidant defenses are thought to be partly responsible. However, there is currently no way to prospectively assess antioxidant defenses in humans. Read More

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http://dx.doi.org/10.2215/CJN.15951219DOI Listing

Ageing of Dental Composites Based on Methacrylate Resins-A Critical Review of the Causes and Method of Assessment.

Polymers (Basel) 2020 Apr 10;12(4). Epub 2020 Apr 10.

Medical University of Lodz, University Laboratory of Materials Research, Pomorska 251, 92-213 Lodz, Poland.

The paper reviews the environmental factors affecting ageing processes, and the degradation of resins, filler, and the filler-matrix interface. It discusses the current methods of testing materials in vitro. A review of literature was conducted with the main sources being PubMed. Read More

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http://dx.doi.org/10.3390/polym12040882DOI Listing

Effects of Aerobic-, Anaerobic- and Combined-Based Exercises on Plasma Oxidative Stress Biomarkers in Healthy Untrained Young Adults.

Int J Environ Res Public Health 2020 Apr 10;17(7). Epub 2020 Apr 10.

Institut Supérieur du Sport et de l'Education Physique de Sfax, Université de Sfax, Sfax 3000, Tunisia.

Currently, it is well accepted that physical exercise-induced oxidative stress may damage biological structures and impair cellular functions. However, it is still unclear which type of exercise results in the greatest oxidative stress responses among a healthy untrained population. The aim of the present study was to compare the acute oxidative stress response (i. Read More

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http://dx.doi.org/10.3390/ijerph17072601DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7178085PMC

Considerations for Stress Testing Performed in Conjunction with Myocardial Perfusion Imaging.

J Nucl Med Technol 2020 Apr 10. Epub 2020 Apr 10.

HCA Healthcare, United Kingdom.

When performing myocardial perfusion imaging (MPI) (1-8), the best test to evaluate hemodynamic changes during stress is an exercise treadmill test. It provides independent prognostic value including evaluation of total exercise time, performance and capacity, heart rate response during exercise, with ischemia, and in recovery, blood pressure response, myocardial oxygen demand and assessment of symptoms. Combining these exercise data with perfusion imaging provides the best prognostic value and risk stratification for patients. Read More

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http://dx.doi.org/10.2967/jnmt.120.245308DOI Listing

Let's Get Physical-Myocardial Stress Tests: A Student's Perspective.

J Nucl Med Technol 2020 Apr 10. Epub 2020 Apr 10.

Cuyahoga Community College, United States.

Myocardial perfusion imaging is a routine study that helps to see if the blood flow to the heart muscle is normal or abnormal. There are three parts to myocardium imaging; the resting scan with the radioactive tracer, the stressing of the myocardium, and the stress scan with the radioactive tracer. With the resting scan, a radioactive tracer is injected into the patient to obtain the first set of images of the myocardium at rest. Read More

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http://dx.doi.org/10.2967/jnmt.120.244947DOI Listing

Left cardiac sympathetic denervation reduces skin sympathetic nerve activity in patients with long QT syndrome.

Heart Rhythm 2020 Apr 8. Epub 2020 Apr 8.

Department of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota. Electronic address:

Background: Although left cardiac sympathetic denervation (LCSD) is an effective antiarrhythmic therapy for patients with long QT syndrome (LQTS), direct evidence of reduced sympathetic activity after LCSD in humans is limited.

Objective: The purpose of this study was to assess skin sympathetic nerve activity (SKNA) in patients with LQTS undergoing LCSD.

Methods: We prospectively enrolled 17 patients with LQTS who underwent LCSD between 2017 and 2019. Read More

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http://dx.doi.org/10.1016/j.hrthm.2020.03.023DOI Listing

Association between proteomics and obstructive sleep apnea phenotypes in a community-based cohort of women.

J Sleep Res 2020 Apr 8:e13041. Epub 2020 Apr 8.

Department of Medical Sciences, Respiratory, Allergy and Sleepss Research, Uppsala University, Uppsala, Sweden.

Proteomic-based technologies offer new opportunities to identify proteins that might reflect the cardiometabolic stress caused by different aspects of sleep-disordered breathing. We aimed to investigate whether severe obstructive sleep apnea and severe obstructive sleep apnea during rapid eye movement sleep are associated with changed levels of inflammatory and cardiac disease-related proteins in a population-based cohort of women. In the community-based "Sleep and Health in Women" (SHE) cohort study, 400 women underwent polysomnography, anthropometric measurements and blood sampling. Read More

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http://dx.doi.org/10.1111/jsr.13041DOI Listing

The role of the enzyme-modified comet assay in in vivo studies.

Toxicol Lett 2020 Jul 2;327:58-68. Epub 2020 Apr 2.

Department of Pharmacology and Toxicology, University of Navarra, C/Irunlarrea 1, 31009, Pamplona, Spain. Electronic address:

The in vivo comet assay is an established genotoxicity test, with an OECD test guideline, but in its standard form it measures only DNA strand breaks. Including in the assay an additional step, in which the DNA is incubated with a lesion-specific enzyme, can provide important information about the nature of the DNA damage. Formamidopyrimidine DNA glycosylase, 8-oxoguanine DNA glycosylase or endonuclease III are commonly used in the in vitro genotoxicity test and in human biomonitoring to detect oxidised bases, but in vivo applications are rarer. Read More

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http://dx.doi.org/10.1016/j.toxlet.2020.03.016DOI Listing

The 2018 Global Research Expedition on Altitude Related Chronic Health (Global REACH) to Cerro de Pasco, Peru: an Experimental Overview.

Exp Physiol 2020 Apr 1. Epub 2020 Apr 1.

Centre for Heart, Lung and Vascular Health, School of Health and Exercise Sciences, University of British Columbia - Okanagan, Kelowna, British Columbia, Canada.

New Findings: What is the central question of this study? Herein, a methodological overview of our research team's (Global REACH) latest high altitude research expedition to Peru is provided. What is the main finding and its importance? The experimental objectives, expedition organization, measurements and key cohort data are discussed. The select data presented in this manuscript demonstrate the haematological differences between lowlanders and Andeans with and without excessive erythrocytosis. Read More

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http://dx.doi.org/10.1113/EP088350DOI Listing

D-ribose-L-cysteine enhances memory task, attenuates oxidative stress and acetyl-cholinesterase activity in scopolamine amnesic mice.

Drug Dev Res 2020 Mar 27. Epub 2020 Mar 27.

Neuropharmacology Unit, Department of Pharmacology and Therapeutics, Faculty of Basic Medical Sciences, College of Medicine, University of Ibadan, Ibadan, Nigeria.

d-Ribose-l-cysteine (DRLC) is an analogue of cysteine that has been shown to boost cellular antioxidant capacity by enhancing intracellular biosynthesis of glutathione (GSH). Deficiency of GSH has been implicated in the pathogenesis of Alzheimer's disease (AD), a neurodegenerative disorder associated with loss of memory. Thus, the use of antioxidants to prevent or retard the progression of memory deteriorations in persons with AD has been the focus of intense investigations. Read More

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http://dx.doi.org/10.1002/ddr.21663DOI Listing
March 2020
0.734 Impact Factor

Assessment of Exercise Stroke Volume and Its Prediction From Oxygen Pulse in Paralympic Athletes With Locomotor Impairments: Cardiac Long-Term Adaptations Are Possible.

Front Physiol 2019 8;10:1451. Epub 2020 Jan 8.

Department of Occupational Therapy, Faculty of Rehabilitation Medicine, University of Alberta, Edmonton, AB, Canada.

The determinants of cardiac output (CO) during exercise, i.e., stroke volume (SV) and heart rate (HR), could differ in Paralympic athletes (PAthl) with spinal cord injury (SCI) with respect to PAthl with locomotor impairments caused by different health conditions (HCs). Read More

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http://dx.doi.org/10.3389/fphys.2019.01451DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7079670PMC
January 2020

Influence of estrous stages on electrocardiography, clinical pathology and ovarian weight of experimental beagle dogs: a retrospective analysis.

Interdiscip Toxicol 2019 Nov 20;12(3):149-156. Epub 2020 Feb 20.

Pharmacology & Toxicology, Zydus Research Centre, Ahmedabad, India.

Estrous cycle is a repetitive phenomenon occurring during the reproductive life of a female dog. The duration of the canine estrous cycle is considerably longer than one in the most of the other animals and is broadly grouped into follicular phase (proestrus and estrus), luteal phase (diestrus) and non-seasonal anestrus. Dogs in the same stage of cycle can be inadvertently assigned to same group during routine safety and metabolic studies leading to possible erroneous interpretation of test-item related effects. Read More

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http://dx.doi.org/10.2478/intox-2019-0018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7085299PMC
November 2019

Cytotoxicity of Halogenated Tyrosyl Compounds, an Emerging Class of Disinfection Byproducts.

Chem Res Toxicol 2020 Apr 1;33(4):1028-1035. Epub 2020 Apr 1.

Division of Analytical and Environmental Toxicology, Department of Laboratory Medicine & Pathology, Faculty of Medicine & Dentistry, University of Alberta, Edmonton, Alberta, Canada T6G 2G3.

Halogenated amino acids and peptides are an emerging class of disinfection byproducts (DBPs), having been detected in drinking water and in washed food products. However, the toxicological significance of these emerging DBPs remains unclear. In this study, the cytotoxicity of eight halogenated tyrosyl compounds was investigated in Chinese hamster ovary (CHO) cells using real-time cell analysis (RTCA). Read More

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http://dx.doi.org/10.1021/acs.chemrestox.0c00049DOI Listing

Neuroprotective effect of regular swimming exercise on calretinin-positive striatal neurons of Parkinsonian rats.

Anat Sci Int 2020 Mar 21. Epub 2020 Mar 21.

Department of Anatomy, School of Medicine, Marmara University, Başıbüyük Yolu No: 9/2 Başıbüyük, Maltepe, Istanbul, Turkey.

In Parkinson's disease (PD), physical therapy is one of the mainstays of supportive treatment modalities. This study focused on the neuroprotective effect of regular exercise on striatal calretinin positive interneurons in a rat model of PD. 6-hydroxydopamine (6-OHDA) was injected unilaterally into the medial forebrain bundle of Wistar rats. Read More

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http://dx.doi.org/10.1007/s12565-020-00538-yDOI Listing

Parents' perspectives on dried blood spot self-sampling from children with epilepsy: A mixed-method study.

Acta Paediatr 2020 Mar 21. Epub 2020 Mar 21.

Department of Laboratory Medicine, Division of Clinical Pharmacology, Karolinska Institutet, Stockholm, Sweden.

Aim: Children with epilepsy often have concomitant diagnoses. Dried blood spot samples for drug monitoring can be collected by parents at home as an alternative to traditional sampling. This mixed-method study aimed to understand the parents' perspectives on blood self-sampling from their children and to identify factors contributing to successful sampling. Read More

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http://dx.doi.org/10.1111/apa.15264DOI Listing

Cafeteria diet administered from lactation to adulthood promotes a change in risperidone sensitivity on anxiety, locomotion, memory, and social interaction of Wistar rats.

Physiol Behav 2020 Jun 16;220:112874. Epub 2020 Mar 16.

Nutrition Department, Experimental Nutrition Laboratory (LabNutrex), Universidade Federal dos Vales do Jequitinhonha e Mucuri, Highway MGT 367 - Km 583, Campus JK, n° 5000, Diamantina, 39100000 MG, Brazil. Electronic address:

Purpose: To evaluate the nutritional status and behavior of animals fed a cafeteria diet from the onset of lactation after the addition of risperidone.

Methods: During the lactation period, 14 litters of Wistar rats (dam + 8 pups) were fed one of two diets: control (CTRL; n = 7) or cafeteria (CAF; n = 7). After weaning, the males were placed in individual cages, receiving the same diet as offered to their respective dams. Read More

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http://dx.doi.org/10.1016/j.physbeh.2020.112874DOI Listing

Ascorbic acid inhibits vascular remodeling induced by mental stress in overweight/obese men.

Life Sci 2020 Jun 14;250:117554. Epub 2020 Mar 14.

Laboratory of Integrative Cardiometabology, Department of Physiology and Pharmacology, Fluminense Federal University, Brazil; Laboratory of Exercise Sciences, Department of Physiology and Pharmacology, Fluminense Federal University, Brazil. Electronic address:

Background: Mental stress (MS) is related to endothelial dysfunction in overweight/obese men. It is believed that the pro-oxidant profile, associated with an imbalance in the vascular remodeling process, may contribute to deleterious effects of MS on endothelial function. However, it is unknown whether administration of ascorbic acid (AA), a potent antioxidant, can prevent oxidative and remodeling dysfunction during MS in these subjects. Read More

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http://dx.doi.org/10.1016/j.lfs.2020.117554DOI Listing

Fitness is improved by adjustments in muscle intracellular signaling in rats with renovascular hypertension 2K1C undergoing voluntary physical exercise.

Life Sci 2020 Jun 13;250:117549. Epub 2020 Mar 13.

Departamento de Ciências Biológicas, Instituto de Ciências Exatas e Biológicas, Universidade Federal de Ouro Preto, Ouro Preto, MG, Brasil; Núcleo de Pesquisa em Ciências Biológicas-Programa de Pós-Graduação em Ciências Biológicas, Universidade Federal de Ouro Preto, Ouro Preto, MG, Brazil; Departamento de Ciências Biológicas, Universidade Federal de Ouro Preto, Ouro Preto, MG, Brazil. Electronic address:

Aim: To evaluate physical fitness and cardiovascular effects in rats with renovascular hypertension, two kidneys, one clip (2K1C) submitted to voluntary exercise (ExV).

Main Methods: 24 h after surgery (SHAM and 2K1C) rats were submitted to ExV for one week (adaptation). ExV adherent rats were separated into exercise (2K1C-EX and SHAM-EX) or sedentary (2K1C-SED and SHAM-SED) groups. Read More

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http://dx.doi.org/10.1016/j.lfs.2020.117549DOI Listing

Memory Function and Brain Functional Connectivity Adaptations Following Multiple-Modality Exercise and Mind-Motor Training in Older Adults at Risk of Dementia: An Exploratory Sub-Study.

Front Aging Neurosci 2020 25;12:22. Epub 2020 Feb 25.

School of Kinesiology, Faculty of Health Sciences, Western University, London, ON, Canada.

Background: Multiple-modality exercise improves brain function. However, whether task-based brain functional connectivity (FC) following exercise suggests adaptations in preferential brain regions is unclear. The objective of this study was to explore memory function and task-related FC changes following multiple-modality exercise and mind-motor training in older adults with subjective cognitive complaints. Read More

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http://dx.doi.org/10.3389/fnagi.2020.00022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7052336PMC
February 2020

Validation of the 3D reconstructed human skin Comet assay, an animal-free alternative for following-up positive results from standard in vitro genotoxicity assays.

Mutagenesis 2020 Mar 10. Epub 2020 Mar 10.

Henkel AG &Co KGaA, Henkelstr. 67, Düsseldorf, Germany.

As part of the safety assessment process, all industrial sectors employ genotoxicity test batteries, starting with well-established in vitro assays. However, these batteries have limited predictive capacity for the in vivo situation, which may result in unnecessary follow-up in vivo testing or the loss of promising substances where animal tests are prohibited or not desired. To address this, a project involving regulators, academia and industry was established to develop and validate in vitro human skin-based genotoxicity assays for topically exposed substances, such as cosmetics ingredients. Read More

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http://dx.doi.org/10.1093/mutage/geaa009DOI Listing