9,242 results match your criteria Pharmacologic Stress Testing


A Thermogenic-Like Brown Adipose Tissue Phenotype is Dispensable for Enhanced Glucose Tolerance in Female Mice.

Diabetes 2019 Mar 12. Epub 2019 Mar 12.

Nutrition and Exercise Physiology, University of Missouri, Columbia, MO, USA

The prevailing dogma is that thermogenic brown adipose tissue (BAT) contributes to improvements in glucose homeostasis in obesogenic animal models; though, much of the evidence supporting this premise is from thermostressed rodents. Whether modulation of the BAT morphology/function drives changes in glucoregulation at thermoneutrality requires further investigation. We utilized loss and gain-of-function approaches including genetic manipulation of the lipolytic enzyme , change in environmental temperature, and lifestyle interventions to comprehensively test the premise that a thermogenic-like BAT phenotype is coupled with enhanced glucose tolerance in female mice. Read More

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http://dx.doi.org/10.2337/db18-1070DOI Listing
March 2019
1 Read

Psychogenic stress in hospitalized veterinary patients: Causation, implications, and therapies.

J Vet Emerg Crit Care (San Antonio) 2019 Mar 12. Epub 2019 Mar 12.

Emergency and Critical Care, The Animal Medical Center, New York, NY.

Objective: To review the sources, adverse effects, diagnosis, treatment, and prevention of psychogenic stress in hospitalized human and veterinary patients.

Data Sources: Data were collected by searching PubMed for veterinary and human literature from the past 10 years.

Human Data Synthesis: Psychogenic stress has been linked to immune suppression; gastrointestinal, cardiovascular, and cutaneous diseases; delayed wound healing; alterations in pain perception; and neurologic impairment. Read More

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http://doi.wiley.com/10.1111/vec.12821
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http://dx.doi.org/10.1111/vec.12821DOI Listing
March 2019
2 Reads

Toxicological evaluation of Picralima nitida in rodents.

J Ethnopharmacol 2019 Mar 7;236:205-219. Epub 2019 Mar 7.

Traditional Medicine Officer, West African Health Organization (WAHO), Burkina Faso. Electronic address:

Picralima nitida (Stapf) T. Durand and H. Durand (Apocynaceae), over the years has shown wide range of usage in African folk medicine and its safety profile in instances of prolonged use and pregnancy are major concerns. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03788741183398
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http://dx.doi.org/10.1016/j.jep.2019.03.008DOI Listing
March 2019
2 Reads

Changes in left ventricular repolarization after short-term testosterone replacement therapy in hypogonadal males.

J Endocrinol Invest 2019 Mar 5. Epub 2019 Mar 5.

Department of Experimental and Clinical Medicine, University of Catanzaro  « Magna Grecia », Catanzaro, Italy.

Background And Aim: Evidences suggest that androgen deficiency is associated with sudden cardiac death (SCD). Our purpose was to analyse some electrocardiographic (ECG) markers of repolarization phase in hypogonadal patients either at baseline or after testosterone replacement therapy (TRT).

Patients And Methods: Baseline and after 6 months of testosterone replacement therapy, 14 hypogonadal patients and 10 age-matched controls underwent a short-term ECG recordings at rest and immediately after a maximal exercise test. Read More

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http://dx.doi.org/10.1007/s40618-019-01026-5DOI Listing
March 2019
2 Reads

Beta -adrenergic ligand racemic formoterol exhibits enantioselective disposition in blood and skeletal muscle of humans, and elicits myocellular protein kinase A-signalling at therapeutic inhaled doses.

Drug Test Anal 2019 Mar 5. Epub 2019 Mar 5.

Discipline of Pharmacy, School of Medicine, University of Tasmania, Hobart, Australia.

While studies have demonstrated substantial differences in beta -adrenergic agonist enantiomer pharmacology, enantioselective disposition of long-acting beta -adrenergic ligand racemic (rac)-formoterol in blood is unexplored after inhaled therapy given analytical challenges. Furthermore, information on enantioselective disposition and partitioning of beta -adrenergic agonist in skeletal muscle is absent despite its promising data on muscle anabolism in humans. Using a sensitive UPLC-MS/MS (ultra-high performance liquid chromatography-mass spectrometry) assay, we determined disposition of (R,R)-formoterol and (S,S)-formoterol in plasma and skeletal muscle samples from 11 non-asthmatic men who had inhaled rac-formoterol at therapeutic doses (2×27 μg). Read More

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http://dx.doi.org/10.1002/dta.2580DOI Listing
March 2019
2 Reads

[Change of short-chain acyl-CoA dehydrogenase in heart failure after myocardial infarction in rats and the intervention of aerobic exercise].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2019 Feb;31(2):172-177

Department of Clinical Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, Guangdong, China.

Objective: To Study the changes of short-chain acyl-CoA dehydrogenase (SCAD) in heart failure (HF) after myocardial infarction (MI), and the effect of aerobic exercise on SCAD.

Methods: Healthy male Sprague-Dawley (SD) rats were divided into sham operation group (Sham group), sham operation swimming group (Sham+swim group), HF model group (LAD group) and HF swimming group (LAD+swim group) by random number table method, with 9 rats in each group. The left anterior descending branch of coronary artery (LAD) was ligated to establish a rat model of HF after MI. Read More

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http://dx.doi.org/10.3760/cma.j.issn.2095-4352.2019.02.010DOI Listing
February 2019

The influence of hERG1a and hERG1b isoforms on drug safety screening in iPSC-CMs.

Prog Biophys Mol Biol 2019 Feb 27. Epub 2019 Feb 27.

Department of Medical Physiology, Division Heart & Lungs, University Medical Center Utrecht, the Netherlands. Electronic address:

The human Ether-à-go-go Related Gene (hERG) encodes the pore forming subunit of the channel that conducts the rapid delayed rectifier potassium current I. I drives repolarization in the heart and when I is dysfunctional, cardiac repolarization delays, the QT interval on the electrocardiogram (ECG) prolongs and the risk of developing lethal arrhythmias such as Torsade de Pointes (TdP) increases. TdP risk is incorporated in drug safety screening for cardiotoxicity where hERG is the main target since the I channels appear highly sensitive to blockage. Read More

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http://dx.doi.org/10.1016/j.pbiomolbio.2019.02.003DOI Listing
February 2019
2 Reads

Methyl B12 protects PC12 cells against cytotoxicity induced by Aβ.

J Cell Biochem 2019 Feb 21. Epub 2019 Feb 21.

Institute of Pharmacology and Toxicology, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, China.

Alzheimer's disease (AD) is the most common aging-associated dementia. The population of AD patients is increasing as the world age grows. Currently, there is no cure for AD. Read More

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http://dx.doi.org/10.1002/jcb.28475DOI Listing
February 2019

The Impact of Hippocampal Sex Hormones Receptors in Modulation of Depressive-Like Behavior Following Chronic Anabolic Androgenic Steroids and Exercise Protocols in Rats.

Front Behav Neurosci 2019 7;13:19. Epub 2019 Feb 7.

Department of Physiology, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia.

The aim of this study was to evaluate alterations in depressive-like behaviors in rats following chronic administration of a supraphysiological dose of anabolic androgenic steroids (AASs) as well as exposure to a prolonged exercise protocol. The role of hippocampal sex hormones receptors in the modulation of depressive-like behavior was also assessed. A total of 48 male Wistar albino rats were divided into six groups: control, exercise (1 h/day, five consecutive days), nandrolone-decanoate (ND, 20 mg/kg/week, in a single dose), exercise plus ND, testosterone-enanthate (TE, 20 mg/kg/week, in a single dose), and exercise plus TE. Read More

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http://dx.doi.org/10.3389/fnbeh.2019.00019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374347PMC
February 2019
2 Reads

p16Ink4a Prevents the Activation of Aged Quiescent Dentate Gyrus Stem Cells by Physical Exercise.

Front Cell Neurosci 2019 7;13:10. Epub 2019 Feb 7.

Institute of Cell Biology and Neurobiology, National Research Council, Foundation Santa Lucia, Rome, Italy.

In the neurogenic niches-the dentate gyrus of the hippocampus and the subventricular zone (SVZ) adjacent to lateral ventricles-stem cells continue to divide during adulthood, generating progenitor cells and new neurons, and to self-renew, thus maintaining the stem cell pool. During aging, the numbers of stem/progenitor cells in the neurogenic niches are reduced. The preservation of the neurogenic pool is committed to a number of antiproliferative genes, with the role of maintaining the quiescence of neural cells. Read More

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http://dx.doi.org/10.3389/fncel.2019.00010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374340PMC
February 2019

The acute effects of caffeine intake on time under tension and power generated during the bench press movement.

J Int Soc Sports Nutr 2019 Feb 18;16(1). Epub 2019 Feb 18.

Department of Sports Training, Jerzy Kukuczka Academy of Physical Education, Katowice, Poland.

Background: The ability to generate high levels of power is one of the key factors determining success in many sport disciplines. Although there are studies confirming ergogenic effects of caffeine (CAF) on different physical and mental abilities, much controversy remains about its influence on power. The main goal of this study was to assess the effects of caffeine supplementation on time under tension (TUT) and the number of performed repetitions (REP). Read More

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http://dx.doi.org/10.1186/s12970-019-0275-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379960PMC
February 2019
1 Read

Self-reported adherence to physical activity recommendations compared to the IPAQ interview in patients with hypertension.

Patient Prefer Adherence 2019 23;13:209-214. Epub 2019 Jan 23.

Postgraduate Studies Program in Cardiology, School of Medicine, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil,

Background: Physical activity (PA) is recommended as adjuvant therapy to control blood pressure (BP). The effectiveness of simple recommendations is not clear. We aimed to assess the agreement between self-report of adherence to PA in clinical routine and International Physical Activity Questionnaire (IPAQ) interview and its association with BP control. Read More

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http://dx.doi.org/10.2147/PPA.S185519DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350830PMC
January 2019
1 Read

Exercise testing oversights underlie missed and delayed diagnosis of catecholaminergic polymorphic ventricular tachycardia in young sudden cardiac arrest survivors.

Heart Rhythm 2019 Feb 11. Epub 2019 Feb 11.

Division of Heart Rhythm Services, Department of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota; Division of Pediatric Cardiology, Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, Minnesota; Windland Smith Rice Sudden Death Genomics Laboratory, Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota. Electronic address:

Background: Catecholaminergic polymorphic ventricular tachycardia (CPVT) is characterized by adrenergically induced ventricular tachycardia, syncope, and sudden cardiac arrest (SCA). In the absence of structural disease, exercise-provoked premature ventricular contractions in bigeminy or couplets and nonsustained ventricular tachycardia are highly predictive of CPVT.

Objective: The purpose of this study was to determine the number of missed or delayed CPVT diagnoses attributable to exercise testing oversights in a cohort of young SCA survivors. Read More

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http://dx.doi.org/10.1016/j.hrthm.2019.02.012DOI Listing
February 2019
2 Reads

TIGAR regulates mitochondrial functions through SIRT1-PGC1α pathway and translocation of TIGAR into mitochondria in skeletal muscle.

FASEB J 2019 Feb 6:fj201802209R. Epub 2019 Feb 6.

Department of Pharmacology and Laboratory of Aging and Nervous Diseases, Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases, School of Pharmaceutical Sciences, Soochow University, Suzhou, China.

TP53-induced glycolysis and apoptosis regulator (TIGAR), a glycolytic inhibitor, plays vital roles in regulating cellular metabolism and oxidative stress. However, the role of highly expressed TIGAR in skeletal muscle remains unexplored. In the present study, TIGAR levels varied in different skeletal muscles and fibers. Read More

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http://dx.doi.org/10.1096/fj.201802209RDOI Listing
February 2019
6 Reads
5.043 Impact Factor

ECEIM consensus statement on equine metabolic syndrome.

J Vet Intern Med 2019 Feb 6. Epub 2019 Feb 6.

Equine Clinic, Internal Medicine, Faculty of Veterinary Medicine, Justus-Liebig-University of Giessen, Giessen, Germany.

Equine metabolic syndrome (EMS) is a widely recognized collection of risk factors for endocrinopathic laminitis. The most important of these risk factors is insulin dysregulation (ID). Clinicians and horse owners must recognize the presence of these risk factors so that they can be targeted and controlled to reduce the risk of laminitis attacks. Read More

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http://dx.doi.org/10.1111/jvim.15423DOI Listing
February 2019
1 Read

Fat Oxidation Rate as a Function of Plasma Lipid and Hormone Response in Endurance Athletes.

J Strength Cond Res 2019 Jan 30. Epub 2019 Jan 30.

Pharmacology and Physiology Department School of Medicine, University of Zaragoza, Zaragoza, Spain.

Soria, M, Ansón, M, Lou-Bonafonte, JM, Andrés-Otero, MJ, Puente, JJ, and Escanero, J. Fat oxidation rate as a function of plasma lipid and hormone response in endurance athletes. J Strength Cond Res XX(X): 000-000, 2019-Plasma lipid changes during incremental exercise are not well known. Read More

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http://dx.doi.org/10.1519/JSC.0000000000003034DOI Listing
January 2019

Multi-Ancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions.

Authors:
Paul S de Vries Michael R Brown Amy R Bentley Yun J Sung Thomas W Winkler Ioanna Ntalla Karen Schwander Aldi T Kraja Xiuqing Guo Nora Franceschini Ching-Yu Cheng Xueling Sim Dina Vojinovic Jennifer E Huffman Solomon K Musani Changwei Li Mary F Feitosa Melissa A Richard Raymond Noordam Hugues Aschard Traci M Bartz Lawrence F Bielak Xuan Deng Rajkumar Dorajoo Kurt K Lohman Alisa K Manning Tuomo Rankinen Albert V Smith Salman M Tajuddin Evangelos Evangelou Mariaelisa Graff Maris Alver Mathilde Boissel Jin Fang Chai Xu Chen Jasmin Divers Ilaria Gandin Chuan Gao Anuj Goel Yanick Hagemeijer Sarah E Harris Fernando P Hartwig Meian He Andrea R V R Horimoto Fang-Chi Hsu Anne U Jackson Anuradhani Kasturiratne Pirjo Komulainen Brigitte Kühnel Federica Laguzzi Joseph H Lee Jian'an Luan Leo-Pekka Lyytikäinen Nana Matoba Ilja M Nolte Maik Pietzner Muhammad Riaz M Abdullah Said Robert A Scott Tamar Sofer Alena Stancáková Fumihiko Takeuchi Bamidele O Tayo Peter J van der Most Tibor V Varga Yajuan Wang Erin B Ware Wanqing Wen Lisa R Yanek Weihua Zhang Jing Hua Zhao Saima Afaq Najaf Amin Marzyeh Amini Dan E Arking Tin Aung Christie Ballantyne Eric Boerwinkle Ulrich Broeckel Archie Campbell Mickaël Canouil Sabanayagam Charumathi Yii-Der Ida Chen John M Connell Ulf de Faire Lisa de Las Fuentes Renée de Mutsert H Janaka de Silva Jingzhong Ding Anna F Dominiczak Qing Duan Charles B Eaton Ruben N Eppinga Jessica D Faul Virginia Fisher Terrence Forrester Oscar H Franco Yechiel Friedlander Mohsen Ghanbari Franco Giulianini Hans J Grabe Megan L Grove C Charles Gu Tamara B Harris Sami Heikkinen Chew-Kiat Heng Makoto Hirata James E Hixson Barbara V Howard M Arfan Ikram David R Jacobs Craig Johnson Jost Bruno Jonas Candace M Kammerer Tomohiro Katsuya Chiea Chuen Khor Tuomas O Kilpeläinen Woon-Puay Koh Heikki A Koistinen Ivana Kolcic Charles Kooperberg Jose E Krieger Steve B Kritchevsky Michiaki Kubo Johanna Kuusisto Timo A Lakka Carl D Langefeld Claudia Langenberg Lenore J Launer Benjamin Lehne Rozenn N Lemaitre Yize Li Jingjing Liang Jianjun Liu Kiang Liu Marie Loh Tin Louie Reedik Mägi Ani W Manichaikul Colin A McKenzie Thomas Meitinger Andres Metspalu Yuri Milaneschi Lili Milani Karen L Mohlke Thomas H Mosley Kenneth J Mukamal Mike A Nalls Matthias Nauck Christopher P Nelson Nona Sotoodehnia Jeff R O'Connell Nicholette D Palmer Raha Pazoki Nancy L Pedersen Annette Peters Patricia A Peyser Ozren Polasek Neil Poulter Leslie J Raffel Olli T Raitakari Alex P Reiner Treva K Rice Stephen S Rich Antonietta Robino Jennifer G Robinson Lynda M Rose Igor Rudan Carsten O Schmidt Pamela J Schreiner William R Scott Peter Sever Yuan Shi Stephen Sidney Mario Sims Blair H Smith Jennifer A Smith Harold Snieder John M Starr Konstantin Strauch Nicholas Tan Kent D Taylor Yik Ying Teo Yih Chung Tham André G Uitterlinden Diana van Heemst Dragana Vuckovic Melanie Waldenberger Lihua Wang Yujie Wang Zhe Wang Wen Bin Wei Christine Williams Gregory Wilson Mary K Wojczynski Jie Yao Bing Yu Caizheng Yu Jian-Min Yuan Wei Zhao Alan B Zonderman Diane M Becker Michael Boehnke Donald W Bowden John C Chambers Ian J Deary Tõnu Esko Martin Farrall Paul W Franks Barry I Freedman Philippe Froguel Paolo Gasparini Christian Gieger Bernardo L Horta Yoichiro Kamatani Norihiro Kato Jaspal S Kooner Markku Laakso Karin Leander Terho Lehtimäki Patrik K E Magnusson Brenda Penninx Alexandre C Pereira Rainer Rauramaa Nilesh J Samani James Scott Xiao-Ou Shu Pim van der Harst Lynne E Wagenknecht Ya Xing Wang Nicholas J Wareham Hugh Watkins David R Weir Ananda R Wickremasinghe Wei Zheng Paul Elliott Kari E North Claude Bouchard Michele K Evans Vilmundur Gudnason Ching-Ti Liu Yongmei Liu Bruce M Psaty Paul M Ridker Rob M van Dam Sharon L R Kardia Xiaofeng Zhu Charles N Rotimi Dennis O Mook-Kanamori Myriam Fornage Tanika N Kelly Ervin R Fox Caroline Hayward Cornelia M van Duijn E Shyong Tai Tien Yin Wong Jingmin Liu Jerome I Rotter W James Gauderman Michael A Province Patricia B Munroe Kenneth Rice Daniel I Chasman L Adrienne Cupples Dabeeru C Rao Alanna C Morrison

Am J Epidemiol 2019 Jan 29. Epub 2019 Jan 29.

Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, Texas.

An individual's lipid profile is influenced by genetic variants and alcohol consumption, but the contribution of interactions between these exposures has not been studied. We therefore incorporated gene-alcohol interactions into a multi-ancestry genome-wide association study of levels of high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and triglycerides. We included 45 studies in Stage 1 (genome-wide discovery) and 66 studies in Stage 2 (focused follow-up), for a total of 394,584 individuals from five ancestry groups. Read More

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https://academic.oup.com/aje/advance-article/doi/10.1093/aje
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http://dx.doi.org/10.1093/aje/kwz005DOI Listing
January 2019
12 Reads
5.230 Impact Factor

Experimental validation of the 3-parameter critical power model in cycling.

Eur J Appl Physiol 2019 Jan 29. Epub 2019 Jan 29.

Department of Molecular and Translational Medicine, University of Brescia, Viale Europa 11, 25123, Brescia, Italy.

Purpose: The three-parameter model of critical power (3-p) implies that in the severe exercise intensity domain time to exhaustion (T) decreases hyperbolically with power output starting from the power asymptote (critical power, ẇ) and reaching 0 s at a finite power limit (ẇ) thanks to a negative time asymptote (k). We aimed to validate 3-p for short T and to test the hypothesis that ẇ represents the maximal instantaneous muscular power.

Methods: Ten subjects performed an incremental test and nine constant-power trials to exhaustion on an electronically braked cycle ergometer. Read More

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http://dx.doi.org/10.1007/s00421-019-04083-zDOI Listing
January 2019
1 Read

Prevention of Long-term Adverse Health Outcomes With Cardiorespiratory Fitness and Physical Activity in Childhood Acute Lymphoblastic Leukemia Survivors.

J Pediatr Hematol Oncol 2019 Jan 25. Epub 2019 Jan 25.

Laboratory of Pathophysiology of EXercise (LPEX), School of Kinesiology and Physical Activity Sciences, Faculty of Medicine, University of Montreal.

Background: Most childhood acute lymphoblastic leukemia (ALL) survivors develop chronic treatment-related adverse effects several years after the end of therapy. A regular practice of physical activity and a good cardiorespiratory fitness have the potential to reduce the risk of chronic disease and improve quality of life. The aim of this study was to evaluate in a cohort of ALL survivors, the association between a good cardiorespiratory fitness or the respect of physical activity guidelines and major long-term health outcomes. Read More

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http://dx.doi.org/10.1097/MPH.0000000000001426DOI Listing
January 2019
1 Read

Urinary Voiding as a Tool to Reduce Radiation Exposure in the Nuclear Stress Lab.

J Nucl Med Technol 2019 Jan 25. Epub 2019 Jan 25.

Mayo Clinic Arizona, United States.

Nuclear stress testing is being increasingly utilized in the cardiovascular risk stratification of patients. Radiation is an important consideration and attempts to minimize exposure should be implemented. Efficiency and cost effectiveness are cornerstones in the delivery of quality patient care and should also be considered when implementing change. Read More

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http://dx.doi.org/10.2967/jnmt.118.212548DOI Listing
January 2019
2 Reads

A role for miR-132 in learned safety.

Sci Rep 2019 Jan 24;9(1):528. Epub 2019 Jan 24.

Department of Neurophysiology and Neuropharmacology, Center for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria.

Learned safety is a fear inhibitory mechanism, which regulates fear responses, promotes episodes of safety and generates positive affective states. Despite its potential as experimental model for several psychiatric illnesses, including post-traumatic stress disorder and depression, the molecular mechanisms of learned safety remain poorly understood, We here investigated the molecular mediators of learned safety, focusing on the characterization of miRNA expression in the basolateral amygdala (BLA). Comparing levels of 22 miRNAs in learned safety and learned fear trained mice, six safety-related miRNAs, including three members of the miR-132/-212 family, were identified. Read More

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http://dx.doi.org/10.1038/s41598-018-37054-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346013PMC
January 2019
2 Reads

Plakophilin-2 Truncation Variants in Patients Clinically Diagnosed With Catecholaminergic Polymorphic Ventricular Tachycardia and Decedents With Exercise-Associated Autopsy Negative Sudden Unexplained Death in the Young.

JACC Clin Electrophysiol 2019 Jan 1;5(1):120-127. Epub 2018 Nov 1.

Department of Molecular Pharmacology & Experimental Therapeutics, Windland Smith Rice Sudden Death Genomics Laboratory, Mayo Clinic, Rochester, Minnesota; Department of Cardiovascular Medicine, Division of Heart Rhythm Services, Mayo Clinic, Rochester, Minnesota; Department of Pediatric and Adolescent Medicine, Division of Pediatric Cardiology, Mayo Clinic, Rochester, Minnesota. Electronic address:

Objectives: This study determined if radical plakophilin-2 (PKP2) variants might underlie some cases of clinically diagnosed catecholaminergic polymorphic ventricular tachycardia (CPVT) and exercise-associated, autopsy-negative sudden unexplained death in the young (SUDY).

Background: Pathogenic variants in PKP2 cause arrhythmogenic right ventricular cardiomyopathy (ARVC). Recently, a cardiomyocyte-specific PKP2 knockout mouse model revealed that loss of PKP2 markedly reduced expression of genes critical in intracellular calcium handling. Read More

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http://dx.doi.org/10.1016/j.jacep.2018.09.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394846PMC
January 2019
1 Read

Dilated cardiomyopathy-mediated heart failure induces a unique skeletal muscle myopathy with inflammation.

Skelet Muscle 2019 Jan 24;9(1). Epub 2019 Jan 24.

Heart Lung Vascular Institute, Division of Cardiology, University of Cincinnati, Cincinnati, OH, 45267, USA.

Background: Skeletal muscle myopathy and exercise intolerance are diagnostic hallmarks of heart failure (HF). However, the molecular adaptations of skeletal muscles during dilated cardiomyopathy (DCM)-mediated HF are not completely understood.

Methods: Skeletal muscle structure and function were compared in wild-type (WT) and cardiac myosin binding protein-C null mice (t/t), which develop DCM-induced HF. Read More

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http://dx.doi.org/10.1186/s13395-019-0189-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345027PMC
January 2019
2 Reads

Grapevine Trunk Diseases: A Review of Fifteen Years of Trials for Their Control with Chemicals and Biocontrol Agents.

Plant Dis 2018 Jul 11;102(7):1189-1217. Epub 2018 Jun 11.

SFR Condorcet, Université de Reims Champagne-Ardenne, URVVC EA 4707, Laboratoire Stress, Défenses et Reproduction des Plantes, BP 1039, Reims, Cedex 2 51687, France.

Grapevine trunk diseases (GTDs) represent one of the most important problems for viticulture worldwide. Beyond the original causes of this outbreak in some countries like France, the lack of efficient control protocols and the prohibition of using active ingredients such as sodium arsenite and benzimidazoles, until recently used to reduce the impact of some GTDs but deleterious for humans and the environment, have probably worsened the impact of the diseases, leading to increasing economic losses. Since 1990, searches have been made to find efficient tools to control GTDs, testing a wide range of active ingredients and biocontrol agents. Read More

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http://dx.doi.org/10.1094/PDIS-08-17-1181-FEDOI Listing

Chitosan Oligosaccharides Induce Apoptosis in Human Renal Carcinoma via Reactive-Oxygen-Species-Dependent Endoplasmic Reticulum Stress.

J Agric Food Chem 2019 Feb 30;67(6):1691-1701. Epub 2019 Jan 30.

Department of Food Sciences and Engineering, School of Chemistry and Chemical Engineering , Harbin Institute of Technology , 92 West Dazhi Street , Nangang District, Harbin , Heilongjiang 150001 , People's Republic of China.

In recent years, various studies have confirmed the role of natural products as effective cancer prevention and treatment drugs. The present study demonstrated that chitosan oligosaccharide (COS) from shells of shrimp and crab caused an inhibitory effect on the proliferation of human renal carcinoma in vitro and in vivo. First, the in vivo biodistribution of COS was investigated by the synthesis of cyanine-7-labeled COS (COS-Cy7) following tail vein injection. Read More

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http://dx.doi.org/10.1021/acs.jafc.8b06941DOI Listing
February 2019
16 Reads

Safety, pharmacodynamics, and potential benefit of omaveloxolone in Friedreich ataxia.

Ann Clin Transl Neurol 2019 Jan 10;6(1):15-26. Epub 2018 Nov 10.

Reata Pharmaceuticals 2801 Gateway Drive Suite 150 Irving Texas 75063.

Objective: Previous studies have demonstrated that suppression of Nrf2 in Friedreich ataxia tissues contributes to excess oxidative stress, mitochondrial dysfunction, and reduced ATP production. Omaveloxolone, an Nrf2 activator and NF-kB suppressor, targets dysfunctional inflammatory, metabolic, and bioenergetic pathways. The dose-ranging portion of this Phase 2 study assessed the safety, pharmacodynamics, and potential benefit of omaveloxolone in Friedreich ataxia patients (NCT02255435). Read More

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http://dx.doi.org/10.1002/acn3.660DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331199PMC
January 2019
4 Reads

Continuous exercise induces airway epithelium damage while a matched-intensity and volume intermittent exercise does not.

Respir Res 2019 Jan 17;20(1):12. Epub 2019 Jan 17.

URePSSS, Unité de Recherche Pluridisciplinaire Sport, Santé, Société, Lille, France.

Background: While continuous exercise (CE) induces greater ventilation ([Formula: see text]) when compared to intermittent exercise (IE), little is known of the consequences on airway damage. Our aim was to investigate markers of epithelial cell damage - i.e. Read More

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http://dx.doi.org/10.1186/s12931-019-0978-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337858PMC
January 2019

International Triadin Knockout Syndrome Registry.

Circ Genom Precis Med 2019 Feb;12(2):e002419

Windland Smith Rice Sudden Death Genomics Laboratory, Department of Molecular Pharmacology and Experimental Therapeutics, Division of Pediatric Cardiology, Department of Pediatric and Adolescent Medicine, and Division of Heart Rhythm Services, Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN (D.J.C., D.J.T., J.R.G., J.M.B., R.K.R., M.J.A.).

Background: Triadin knockout syndrome (TKOS) is a rare, inherited arrhythmia syndrome caused by recessive null mutations in TRDN-encoded cardiac triadin. Based previously on 5 triadin null patients, TKOS has been characterized by extensive T-wave inversions, transient QT prolongation, and severe disease expression of exercise-induced cardiac arrest in early childhood refractory to conventional therapy.

Methods: We have established the International Triadin Knockout Syndrome Registry to include patients who have genetically proven homozygous/compound heterozygous TRDN null mutations. Read More

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http://dx.doi.org/10.1161/CIRCGEN.118.002419DOI Listing
February 2019
17 Reads

Resilience characteristics and prior life stress determine anticipatory response to acute social stress in children aged 7-11 years.

Br J Health Psychol 2019 Jan 13. Epub 2019 Jan 13.

Department of Health, University of Bath, UK.

Objectives: To assess the interplay of prior life stress and characteristics of resilience in determining how children cope with potentially stressful situations, using a two-phase study that triangulates parent-child dyadic interview data with subsequent experience of an acute laboratory stressor in 7-11-year-olds.

Methods: Participants (n = 34) were designated as being in one of four groups based on high/low levels of prior stress experience and high/low resilience ratings assessed during at-home interviews and from questionnaires measuring recent life events, hassles, and trait coping. During a subsequent laboratory stress protocol, salivary cortisol and heart rate were monitored, and a verbal subjective report was provided. Read More

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http://dx.doi.org/10.1111/bjhp.12353DOI Listing
January 2019
1 Read

SR Ca leak in skeletal muscle fibers acts as an intracellular signal to increase fatigue resistance.

J Gen Physiol 2019 Jan 11. Epub 2019 Jan 11.

Department of Physiology and Pharmacology, Biomedicum C5, Karolinska Institutet, Stockholm, Sweden

Effective practices to improve skeletal muscle fatigue resistance are crucial for athletes as well as patients with dysfunctional muscles. To this end, it is important to identify the cellular signaling pathway that triggers mitochondrial biogenesis and thereby increases oxidative capacity and fatigue resistance in skeletal muscle fibers. Here, we test the hypothesis that the stress induced in skeletal muscle fibers by endurance exercise causes a reduction in the association of FK506-binding protein 12 (FKBP12) with ryanodine receptor 1 (RYR1). Read More

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http://www.jgp.org/lookup/doi/10.1085/jgp.201812152
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http://dx.doi.org/10.1085/jgp.201812152DOI Listing
January 2019
12 Reads

Women Experience the Same Ergogenic Response to Caffeine as Men.

Med Sci Sports Exerc 2019 Jan 8. Epub 2019 Jan 8.

School of Human Movement and Nutrition Sciences, The University of Queensland, Australia.

Purpose: This study aimed to determine if 1) consumption of caffeine improves endurance cycling performance in women, and 2) sex differences exist in the magnitude of the ergogenic and plasma responses to caffeine supplementation.

Methods: Twenty-seven (11 women and 16 men) endurance-trained cyclists and triathletes participated in this randomized, double-blind, placebo-controlled, crossover study. Participants completed an incremental exercise test to exhaustion, two familiarization trials and two performance trials. Read More

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http://dx.doi.org/10.1249/MSS.0000000000001885DOI Listing
January 2019

Short-Term Environmental Stimulation Spatiotemporally Modulates Specific Serotonin Receptor Gene Expression and Behavioral Pharmacology in a Sexually Dimorphic Manner in Huntington's Disease Transgenic Mice.

Front Mol Neurosci 2018 10;11:433. Epub 2018 Dec 10.

Florey Institute of Neuroscience and Mental Health, Melbourne Brain Centre, University of Melbourne, Parkville, VIC, Australia.

Huntington's disease (HD) is a neurodegenerative disorder caused by a tandem repeat mutation encoding an expanded polyglutamine tract in the huntingtin protein, which leads to cognitive, psychiatric and motor dysfunction. Exposure to environmental enrichment (EE), which enhances levels of cognitive stimulation and physical activity, has therapeutic effects on cognitive, affective and motor function of transgenic HD mice. The present study investigated gene expression changes and behavioral pharmacology in male and female R6/1 transgenic HD mice at an early time-point in HD progression associated with onset of cognitive and affective abnormalities, following EE and exercise (wheel running) interventions. Read More

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http://dx.doi.org/10.3389/fnmol.2018.00433DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295568PMC
December 2018
7 Reads

Effects of caffeine ingestion on the diurnal variation of cognitive and repeated high-intensity performances.

Pharmacol Biochem Behav 2019 Feb 3;177:69-74. Epub 2019 Jan 3.

Institut Supérieur du Sport et de l'Education Physique de Sfax, Université de Sfax, Tunisie; Activité Physique: Sport et Santé, UR18JS01, Observatoire National du Sport, Tunis, Tunisie.

The purpose of this study was to evaluate the effects of caffeine ingestion on the daily variation of cognitive (i.e., reaction time (RT), attention) and repeated high-intensity exercise performances. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00913057183035
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http://dx.doi.org/10.1016/j.pbb.2019.01.001DOI Listing
February 2019
2 Reads

Pterostilbene, an active component of the dragon's blood extract, acts as an antidepressant in adult rats.

Psychopharmacology (Berl) 2019 Jan 4. Epub 2019 Jan 4.

School of Life Science, Beijing Institute of Technology, Beijing, 100081, People's Republic of China.

Background: Hippocampal neurogenesis has been widely considered as one of the potential biological mechanisms for the treatment of depression caused by chronic stress. Many natural products have been reported to be beneficial for neurogenesis.

Objectives: The present study is designed to investigate the effect of dragon's blood extract (DBE) and its biologically active compound, pterostilbene (PTE), on hippocampal neurogenesis. Read More

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http://dx.doi.org/10.1007/s00213-018-5138-7DOI Listing
January 2019
3 Reads
3.875 Impact Factor

Preparation of a biomimetic ECM surface on cardiovascular biomaterials via a novel layer-by-layer decellularization for better biocompatibility.

Mater Sci Eng C Mater Biol Appl 2019 Mar 30;96:509-521. Epub 2018 Nov 30.

Key Lab. for Advanced Technologies of Materials, Ministry of Education, School of Material Science and Engineering, Southwest Jiaotong University, Chengdu 610031, PR China.

Endothelial extracellular matrix (EC-ECM) modification by decellularization is generally recognized as an effective method for cardiovascular biomaterials to enhance their biocompatibility. However, the now available EC-ECM was mainly secreted by the in vitro cultured endothelial cells which lacked a physiological growth environment in vivo, such as blood flow shear stress (BFSS) acting, thus had a serious defect of biocompatibility. Our previous work markedly improved the biocompatibility of the EC-ECM modified materials by simulating the BFSS acting to control the endothelial cells with hyaluronic acid (HA) micro-pattern. Read More

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http://dx.doi.org/10.1016/j.msec.2018.11.078DOI Listing
March 2019
2 Reads
3.088 Impact Factor

Tempering aversive/traumatic memories with cannabinoids: a review of evidence from animal and human studies.

Psychopharmacology (Berl) 2019 Jan 2;236(1):201-226. Epub 2019 Jan 2.

Department of Pharmacology, Medical School of Ribeirão Preto, University of São Paulo (FMRP/USP), Av Bandeirantes 3900, Monte Alegre, 14049900, Ribeirão Preto, São Paulo, Brazil.

Rationale: Aversive learning and memory are essential to cope with dangerous and stressful stimuli present in an ever-changing environment. When this process is dysfunctional, however, it is associated with posttraumatic stress disorder (PTSD). The endocannabinoid (eCB) system has been implicated in synaptic plasticity associated with physiological and pathological aversive learning and memory. Read More

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http://dx.doi.org/10.1007/s00213-018-5127-xDOI Listing
January 2019
2 Reads

Clinical correlates and outcome associated with changes in 6-minute walking distance in patients with heart failure: findings from the BIOSTAT-CHF study.

Eur J Heart Fail 2019 Feb 1;21(2):218-226. Epub 2019 Jan 1.

INSERM, Centre d'Investigations Cliniques Plurithématique 1433, Université de Lorraine, CHRU de Nancy and F-CRIN INI-CRCT, Nancy, France.

Background: The 6-minute walk test (6MWT) is a simple and inexpensive way of measuring exercise capacity in patients with heart failure (HF) that predicts morbidity and mortality. However, there are few reports from large multicentre cohorts assessing the predictive value of baseline and changing walk distance.

Methods And Results: In BIOSTAT-CHF, a 6MWT was performed at baseline (n = 1714) and 9 months (n = 1520). Read More

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http://doi.wiley.com/10.1002/ejhf.1380
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http://dx.doi.org/10.1002/ejhf.1380DOI Listing
February 2019
6 Reads
6.526 Impact Factor

Effects of Six-Month Aerobic Exercise Intervention on Sleep in Healthy Older Adults in the Study: A Pilot Study.

J Alzheimers Dis Rep 2018 Dec 24;2(1):229-238. Epub 2018 Dec 24.

Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.

Background: Sleep disturbances have been shown to be associated with the presence of the apolipoprotein () 4 allele, the well-known genetic risk factor for late-onset sporadic Alzheimer's disease (AD).

Objective: This study quantifies the effects of a six-month aerobic exercise intervention on objective and subjective sleep quality in middle-aged to older individuals including those at increased genetic risk for late-onset sporadic Alzheimer's disease (AD), who carry the apolipoprotein () 4 risk allele.

Methods: 199 sedentary men and women without significant cognitive impairments were enrolled in the study, a quasi-experimental single group pre-test/post-test study with no control group. Read More

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https://www.medra.org/servlet/aliasResolver?alias=iospress&a
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http://dx.doi.org/10.3233/ADR-180079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311349PMC
December 2018
9 Reads

Matrine Attenuates D-Galactose-Induced Aging-Related Behavior in Mice Inhibition of Cellular Senescence and Oxidative Stress.

Oxid Med Cell Longev 2018 27;2018:7108604. Epub 2018 Nov 27.

College of Animal Science and Veterinary Medicine, Shanxi Agricultural University, Taigu 030801 Shanxi, China.

The present study was designed to evaluate the effects of matrine (MAT) on D-galactose- (D-gal-) induced aging and relative mechanism. Vitamin E at the dose of 100 mg/kg was used as a standard positive control. MAT significantly improved the D-gal-induced recognition and spatial memory impairment in novel object recognition and Y maze tests, and exercise endurance decreased in the weight-loaded swimming test at 2 and 10 mg/kg. Read More

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http://dx.doi.org/10.1155/2018/7108604DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288577PMC
February 2019
2 Reads

Veterans have greater variability in their perception of binocular alignment.

PLoS One 2018 26;13(12):e0209622. Epub 2018 Dec 26.

War Related Illness and Injury Study Center, Department of Veteran Affairs, NJ, United States of America.

Introduction: A significant population of our wounded veterans suffer long-term functional consequences of visual deficit, disorientation, dizziness, and an impaired ability to read. These symptoms may be related to damage within the otolith pathways that contribute to ocular alignment. The purpose of this study was to compare perception of vertical and torsional ocular alignment between veterans and healthy controls in an upright and supine test position. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0209622PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306227PMC
December 2018
7 Reads
3.234 Impact Factor

Acute heat stress reduces biomarkers of endothelial activation but not macro- or microvascular dysfunction in cervical spinal cord injury.

Am J Physiol Heart Circ Physiol 2019 Mar 21;316(3):H722-H733. Epub 2018 Dec 21.

Centre for Heart, Lung and Vascular Health, University of British Columbia Okanagan , Kelowna, British Columbia , Canada.

Cardiovascular diseases (CVD) are highly prevalent in spinal cord injury (SCI), and peripheral vascular dysfunction might be a contributing factor. Recent evidence demonstrates that exposure to heat stress can improve vascular function and reduce the risk of CVD in uninjured populations. We therefore aimed to examine the extent of vascular dysfunction in SCI and the acute effects of passive heating. Read More

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http://dx.doi.org/10.1152/ajpheart.00693.2018DOI Listing
March 2019
2 Reads

Comparing effects of 4 months of two self-administered exercise training programs on physical performance in patients with chronic kidney disease: RENEXC - A randomized controlled trial.

PLoS One 2018 20;13(12):e0207349. Epub 2018 Dec 20.

Department of Nephrology, Institution of Clinical Sciences, Faculty of Medicine, Lund University, Skåne University Hospital, Lund, Sweden.

Background: Exercise training is recommended to patients with chronic kidney disease (CKD). However, the level of evidence is still low. This randomized controlled trial (RCT) compared two different and self-administered exercise training programs in a representative CKD population. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0207349PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6301660PMC
December 2018

Safely Identifying Emergency Department Patients With Acute Chest Pain for Early Discharge.

Circulation 2018 Nov;138(22):2456-2468

Department of Emergency Medicine (S.A.M., B.C.H., C.D.M.), Wake Forest School of Medicine, Winston-Salem, NC.

Background: The HEART Pathway (history, ECG, age, risk factors, and initial troponin) is an accelerated diagnostic protocol designed to identify low-risk emergency department patients with chest pain for early discharge without stress testing or angiography. The objective of this study was to determine whether implementation of the HEART Pathway is safe (30-day death and myocardial infarction rate <1% in low-risk patients) and effective (reduces 30-day hospitalizations) in emergency department patients with possible acute coronary syndrome.

Methods: A prospective pre-post study was conducted at 3 US sites among 8474 adult emergency department patients with possible acute coronary syndrome. Read More

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.036528DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309794PMC
November 2018
8 Reads

Molecular adaptations in human subcutaneous adipose tissue after ten weeks of endurance exercise training in healthy males.

J Appl Physiol (1985) 2019 Mar 20;126(3):569-577. Epub 2018 Dec 20.

Research Laboratory for Biochemical Pathology, Department of Clinical Medicine, Aarhus University , Aarhus , Denmark.

Endurance exercise training induces adaptations in metabolically active organs, but adaptations in human subcutaneous adipose tissue (scAT) remains incompletely understood. On the basis of animal studies, we hypothesized that endurance exercise training would increase the expression of proteins involved in lipolysis and glucose uptake in scAT. To test these hypotheses, 19 young and healthy males were randomized to either endurance exercise training (TR; age 18-24 yr; BMI 19. Read More

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http://dx.doi.org/10.1152/japplphysiol.00989.2018DOI Listing
March 2019
3 Reads

Study of Myocardial Perfusion in Obese Individuals without Known Ischemic Heart Disease.

Arq Bras Cardiol 2019 Feb 17;112(2):121-128. Epub 2018 Dec 17.

Clínica Quanta Diagnóstico e Terapia, Curitiba, PR - Brazil.

Background: Obesity is associated with an increased risk of type 2 diabetes mellitus (DM), ischemic heart disease (IHD) and cardiovascular mortality. Several studies have demonstrated the diagnostic and prognostic value of single photon computed tomography-myocardial perfusion scintigraphy (SPECT-MPI) in the evaluation of patients with suspected IHD, including in obese population. Data on clinical risk factors and their association with abnormal myocardial perfusion in obese patients are scarce in the Brazilian population. Read More

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http://www.gnresearch.org/doi/10.5935/abc.20180250
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http://dx.doi.org/10.5935/abc.20180250DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371823PMC
February 2019
13 Reads

Human kidney on a chip assessment of polymyxin antibiotic nephrotoxicity.

JCI Insight 2018 Dec 20;3(24). Epub 2018 Dec 20.

Department of Pharmaceutics.

Drug-induced kidney injury, largely caused by proximal tubular intoxicants, limits development and clinical use of new and approved drugs. Assessing preclinical nephrotoxicity relies on animal models that are frequently insensitive; thus, potentially novel techniques - including human microphysiological systems, or "organs on chips" - are proposed to accelerate drug development and predict safety. Polymyxins are potent antibiotics against multidrug-resistant microorganisms; however, clinical use remains restricted because of high risk of nephrotoxicity and limited understanding of toxicological mechanisms. Read More

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http://dx.doi.org/10.1172/jci.insight.123673DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338315PMC
December 2018
15 Reads

Plasma asymmetric dimethylarginine concentrations are not related to differences in maximal oxygen uptake in endurance trained and untrained men.

Exp Physiol 2019 Feb 18;104(2):254-263. Epub 2018 Dec 18.

University of Lille, University of Artois, University of Littoral Côte, d'Opale, EA 7369 - URePSSS, Pluridisciplinary Research Unit, "Sport, Health and Society", F-59000, Lille, France.

New Findings: What is the central question of this study? Is there an association of plasma concentration of asymmetric dimethylarginine, which is related to exercise capacity in patients with cardiovascular diseases, with oxygen delivery and subsequently exercise capacity in healthy subjects in the absence of the potentially confounding influence of inflammation and oxidative stress? What is the main finding and its importance? Plasma asymmetric dimethylarginine concentrations are not related to exercise capacity in healthy subjects, while O delivery in the working skeletal muscle during the maximal graded-exercise test is not associated with any of the l-arginine analogues. ADMA alone does not play a crucial role in local muscle perfusion and in maintaining exercise capacity.

Abstract: Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide (NO) synthesis that could limit oxygen (O ) delivery in the working skeletal muscles by altering endothelium-dependent vasodilatation. Read More

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http://dx.doi.org/10.1113/EP087398DOI Listing
February 2019
2 Reads

Kaempferol attenuates diabetic nephropathy by inhibiting RhoA/Rho-kinase mediated inflammatory signalling.

Biomed Pharmacother 2019 Jan 15;109:1610-1619. Epub 2018 Nov 15.

Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER)-Ahmedabad, Gandhinagar, 382355, Gujarat, India; Department of Biotechnology, National Institute of Pharmaceutical Education and Research (NIPER)-Ahmedabad, Gandhinagar, 382355, Gujarat, India. Electronic address:

RhoA/Rho-associated coiled-coil forming protein serine/threonine kinase (ROCK) has appeared as a potential therapeutic target in numerous diseases, because of its preventing action on various enzymes providing antioxidant and cytoprotective action. Progression and pathophysiology of diabetic nephropathy have also shown potential involvement of oxidative stress and inflammatory pathways. In the present study, we investigated the effect of kaempferol on hyperglycemia-induced activation of RhoA kinase and associated inflammatory signaling cascade. Read More

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http://dx.doi.org/10.1016/j.biopha.2018.10.195DOI Listing
January 2019