10,886 results match your criteria Pharmacologic Stress Testing


Stress axis programming generates long-term effects on cognitive abilities in a cooperative breeder.

Proc Biol Sci 2022 May 18;289(1975):20220117. Epub 2022 May 18.

Division of Behavioural Ecology, Institute of Ecology and Evolution, University of Bern, Wohlenstrasse 50A, CH-3032 Hinterkappelen, Switzerland.

The ability to flexibly adjust behaviour to social and non-social challenges is important for successfully navigating variable environments. Social competence, i.e. Read More

View Article and Full-Text PDF

Adenosine, caffeine, and sleep-wake regulation: state of the science and perspectives.

J Sleep Res 2022 May 16. Epub 2022 May 16.

Institute of Pharmacology and Toxicology, University of Zürich, Zürich, Switzerland.

For hundreds of years, mankind has been influencing its sleep and waking state through the adenosinergic system. For ~100 years now, systematic research has been performed, first started by testing the effects of different dosages of caffeine on sleep and waking behaviour. About 70 years ago, adenosine itself entered the picture as a possible ligand of the receptors where caffeine hooks on as an antagonist to reduce sleepiness. Read More

View Article and Full-Text PDF

Exercise capacity assessed with the one-minute sit-to-stand test (1-min STST) and echocardiographic findings in patients with heart failure with preserved ejection fraction (HFpEF).

Heart Lung 2022 May 11;55:134-139. Epub 2022 May 11.

Department of Internal Medicine II, Division of Cardiology, Medical University of Vienna, Währinger Gürtel 18-20, 1090 Vienna, Austria. Electronic address:

Background: Heart failure with preserved ejection fraction (HFpEF) is a major cause of morbidity and mortality. Precise risk stratification remains challenging. The one-minute sit-to-stand-test (1-min STST), a quick, objective test of functional capacity may be helpful for stratification of clinical profile in HFpEF patients. Read More

View Article and Full-Text PDF

Acute Effects of Caffeine on Overall Performance in Basketball Players-A Systematic Review.

Nutrients 2022 May 5;14(9). Epub 2022 May 5.

Department of Biomedical Sciences for Health, Università degli Studi di Milano, 20133 Milan, Italy.

Caffeine supplementation has become increasingly popular among athletes. The benefits of caffeine include delaying the negative effects of fatigue, maintaining a high level of physical and mental performance, and improving certain abilities necessary for sport success. Given the complex nature of basketball, caffeine could be a legal, ergogenic stimulant substance, which will positively affect overall basketball performance. Read More

View Article and Full-Text PDF

Effects of Trehalose Solutions at Different Concentrations on High-Intensity Intermittent Exercise Performance.

Nutrients 2022 Apr 23;14(9). Epub 2022 Apr 23.

Hayashibara, Co., Ltd., 675-1, Fujisaki, Naka-ku 702-8006, Okayama, Japan.

Trehalose solution ingested during exercise induces gradual increases in blood glucose levels and the insulin response compared with glucose solution. Trehalose solution aids in the maintenance of performance in the later stages of prolonged exercise. The purpose of this study was to identify the lowest concentration at which the properties of trehalose could be exploited. Read More

View Article and Full-Text PDF

Effects of Multi-Ingredient Pre-Workout Supplement and Caffeine on Bench Press Performance: A Single-Blind Cross-Over Study.

Nutrients 2022 Apr 22;14(9). Epub 2022 Apr 22.

Department of Physical Education, Józef Piłsudski Univesity of Physical Education in Warsaw, 00-809 Warszawa, Poland.

The problem addressed in this study is the appropriateness of using different pre-training supplementation strategies and their ability to improve training performance and psychological measures. The aim of the study is the evaluation of the effectiveness of a multi-ingredient pre-workout supplement (MIPS) containing beta-alanine, L-citrulline malate, arginine alpha-ketoglutarate, L-taurine, L-tyrosine and caffeine compared to an exact dosage of anhydrous caffeine in bench press strength endurance, feeling scale (FS), felt arousal scale (FAS) and session rating of perceived exertion (sRPE). A group of fifteen resistance-trained males, weighing 83. Read More

View Article and Full-Text PDF

Dietary nanoparticles compromise epithelial integrity and enhance translocation and antigenicity of milk proteins: An in vitro investigation.

NanoImpact 2021 Oct 23;24:100369. Epub 2021 Nov 23.

Department of Food Science and Agricultural Chemistry, McGill University, 21111 Lakeshore Dr, Sainte-Anne-de-Bellevue, QC H9X, Canada. Electronic address:

Nanoparticles (NPs) are increasingly being used in the food sector, yet little is known about the potential health risks associated with oral exposure to dietary NPs. In this study, the most widely used NPs in food industry including food grade silicon dioxide (SiO), titanium dioxide (TiO) and silver (Ag), along with their non-food grade and bulk counterparts, are characterized for physicochemical properties and molecular, cellular, and intracellular effects on human intestinal epithelial cells (Caco-2 and HIEC-6). Silver NPs are the most cytotoxic and induce significant cellular changes in oxidative stress, Ca flux and mitochondria function, leading to cellular junction disruption at the lowest exposure concentration. Read More

View Article and Full-Text PDF
October 2021

The nutraceutical properties and health benefits of pseudocereals: a comprehensive treatise.

Crit Rev Food Sci Nutr 2022 May 13:1-13. Epub 2022 May 13.

Jiangxi Key Laboratory for Postharvest Technology and Nondestructive Testing of Fruits & Vegetables, College of Agronomy, Jiangxi Agricultural University, Nanchang, PR China.

This review article depicts the possible replacement of staple cereal sources with some pseudocereals like Chia, Quinoa, Buckwheat, and Amaranth, which not only provide recommended daily allowance of all nutrients but also help to reduce the chances of many non-communicable infections owing to the presence of several bioactive compounds. These pseudocereals are neglected plant seeds and should be added in our routine diet. Besides, they can serve as nutraceuticals in combating various diseases by improving the health status of the consumers. Read More

View Article and Full-Text PDF

A blended learning exercise physiology theory-module that supports student autonomy and improves academic performance.

Adv Physiol Educ 2022 May 12. Epub 2022 May 12.

Department of Microbiology, Anatomy, Physiology and Pharmacology, School of Agriculture, Biomedicine and Environment, La Trobe University, Melbourne, Victoria, Australia.

A limited number of studies have explored the impact of blended exercise physiology theory curricula on student learning and experience. This study aimed to investigate the impact of an exercise physiology blended learning theory module on student performance, engagement, and perceptions. The module, comprised a range of elements (student guide, lecturer-recorded videos, supplementary videos, formative quizzes, workshops, and discussion forum), was implemented in a third-year subject taken by students in non-specialist undergraduate science, technology, engineering, and mathematics (STEM) degrees. Read More

View Article and Full-Text PDF

The influence of exercise and postural changes on ventricular repolarization in the long QT syndrome: a systematic scoping review.

Eur J Prev Cardiol 2022 May 10. Epub 2022 May 10.

Sainte-Justine University Health Center, Research Center, Montreal, Canada.

Current exercise recommendations make it difficult for long QT syndrome (LQTS) patients to adopt a physically active and/or athletic lifestyle. The purpose of this review is to summarize the current evidence, identify knowledge gaps, and discuss research perspectives in the field of exercise and LQTS. The first aim is to document the influence of exercise training, exercise stress, and postural change interventions on ventricular repolarization in LQTS patients, while the second aim is to describe electrophysiological measurements used to study the above. Read More

View Article and Full-Text PDF

Prophylactic effect of . seed extract on inflammatory markers and histopathological changes in high-fat-fed ovariectomized rats.

J Tradit Complement Med 2022 Mar 18;12(2):131-140. Epub 2021 Jul 18.

Department of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal Academy, of Higher Education, Manipal, Karnataka, 576104, India.

Background And Aim: L. seeds (TFG) are used as spices in Indian cuisine. In Indian traditional medicine, TFG is used to treat diabetes, dyslipidemia, obesity, arthritis, cancer, digestive disorders, and postmenopausal conditions. Read More

View Article and Full-Text PDF

Neurovascular Dysregulation and Acute Exercise Intolerance in ME/CFS: A Randomized, Placebo-Controlled Trial of Pyridostigmine.

Chest 2022 May 5. Epub 2022 May 5.

Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA. Electronic address:

Background: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is characterized by intractable fatigue, post-exertional malaise, and orthostatic intolerance, but its pathophysiology is poorly understood. Pharmacologic cholinergic stimulation was used to test the hypothesis that neurovascular dysregulation underlies exercise intolerance in ME/CFS.

Research Question: Does neurovascular dysregulation contribute to exercise intolerance in ME/CFS and can its treatment improve exercise capacity?

Methods: Forty-five subjects with ME/CFS were enrolled in a single-center, randomized, double-blind, placebo-controlled trial. Read More

View Article and Full-Text PDF

Aerobic exercise training engages cholinergic signaling to improve emphysema induced by cigarette smoke exposure in mice.

Life Sci 2022 May 2;301:120599. Epub 2022 May 2.

Department of Bioscience, Federal University of São Paulo, Campus Baixada Santista, Santos, Brazil; Department of Clinical Medicine (LIM-20), School of Medicine, University of São Paulo, São Paulo, Brazil. Electronic address:

Lung inflammation is modulated by cholinergic signaling and exercise training protects mice against pulmonary emphysema development; however, whether exercise training engages cholinergic signaling is unknown.

Aims: As cholinergic signaling is directly linked to the vesicular acetylcholine transporter (VAChT) levels, we evaluated whether the effects of aerobic exercise training depend on the VAChT levels in mice with pulmonary emphysema.

Main Methods: Wild-type (WT) and mutant (KD) mice (65-70% of reduction in VAChT levels) were exposed to cigarette smoke (30 min, 2×/day, 5×/week, 12 weeks) and submitted or not to aerobic exercise training on a treadmill (60 min/day, 5×/week, 12 weeks). Read More

View Article and Full-Text PDF

Neuroprotective Effect of Piclamilast-Induced Post-Ischemia Pharmacological Treatment in Mice.

Neurochem Res 2022 Apr 28. Epub 2022 Apr 28.

Faculty of Veterinary Medicine, Pharmacology Department, Suez Canal University, Ismailia, 41522, Egypt.

Various studies have evidenced the neuroprotective role of PDE4 inhibitors. However, whether PDE4 inhibitor, Piclamilast pharmacological post-treatment is protective during cerebral ischemia reperfusion-induced injury remains unknown. Therefore, this study design included testing the hypothesis that Piclamilast administered at the beginning of a reperfusion phase (Piclamilast pPost-trt) shows protective effects and explores & probes underlying downstream mechanisms. Read More

View Article and Full-Text PDF

In Vitro Investigation of the Impact of Bacterial-Fungal Interaction on Carbapenem-Resistant .

Molecules 2022 Apr 14;27(8). Epub 2022 Apr 14.

Department of Botany and Microbiology, Faculty of Science, Cairo University, Giza 12613, Egypt.

Fungal-bacterial co-culturing is a potential technique for the production of secondary metabolites with antibacterial activity. Twenty-nine fungal species were screened in a co-culture with carbapenem-resistant at different temperatures. A temperature of 37 ° showed inhibition of bacterial growth. Read More

View Article and Full-Text PDF

Formulation and Testing of Antioxidant and Protective Effect of Hyalurosomes Loading Extract Rich in Rosmarinic Acid Biotechnologically Produced from Miller.

Molecules 2022 Apr 8;27(8). Epub 2022 Apr 8.

Department of Scienze della Vita e dell'Ambiente, University of Cagliari, 09124 Cagliari, Italy.

Culture of plant cells or tissues is a scalable, sustainable, and environmentally friendly approach to obtain extracts and secondary metabolites of uniform quality that can be continuously supplied in controlled conditions, independent of geographical and seasonal variations, environmental factors, and negative biological influences. In addition, tissues and cells can be extracted/obtained from the by-products of other industrial cultivations such as that of Miller (), which is largely cultivated for the collection of flowers. Given that, an extract rich in rosmarinic acid was biotechnologically produced starting from cell suspension of , which was then loaded in hyalurosomes, special phospholipid vesicles enriched with sodium hyaluronate, which in turn are capable of both immobilizing and stabilizing the system. Read More

View Article and Full-Text PDF

Acute Effect of Caffeine-Based Multi-Ingredient Supplement on Reactive Agility and Jump Height in Recreational Handball Players.

Nutrients 2022 Apr 9;14(8). Epub 2022 Apr 9.

Department of Water Sports, Faculty of Physical Education and Sport, University of Physical Education, 31-571 Kraków, Poland.

Pre-exercise caffeine and guarana-based multi-ingredient supplement (MS) consumption may be more effective for physical performance improvement than caffeine and guarana alone due to the synergistic effect of biologically active ingredients in multi-ingredient supplements. This study aimed to examine the acute effect of MS on the reactive agility and jump performance in recreational handball male players. A randomized, double-blind, crossover study involved twenty-four male handball players (body mass 74. Read More

View Article and Full-Text PDF

Building knowledge, optimising physical and mental health and setting up healthier life trajectories in South African women (): a preconception randomised control trial part of the Healthy Life Trajectories Initiative (HeLTI).

BMJ Open 2022 Apr 21;12(4):e059914. Epub 2022 Apr 21.

Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada.

Introduction: South Africa's evolving burden of disease is challenging due to a persistent infectious disease, burgeoning obesity, most notably among women and rising rates of non-communicable diseases (NCDs). With two thirds of women presenting at their first antenatal visit either overweight or obese in urban South Africa (SA), the preconception period is an opportunity to optimise health and offset transgenerational risk of both obesity and NCDs.

Methods And Analysis: is the first individual randomised controlled trial in Africa to test the efficacy of a complex continuum of care intervention and forms part of the Healthy Life Trajectories Initiative (HeLTI) consortium implementing harmonised trials in Canada, China, India and SA. Read More

View Article and Full-Text PDF

Beta-Blockers and Exercise Hemodynamics in Hypertrophic Cardiomyopathy.

J Am Coll Cardiol 2022 04;79(16):1576-1578

Department of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, USA.

View Article and Full-Text PDF

Design and Synthesis of Novel 1,3,4-Oxadiazole and 1,2,4-Triazole Derivatives as Cyclooxygenase-2 Inhibitors with Anti-inflammatory and Antioxidant activity in LPS-stimulated RAW264.7 Macrophages.

Bioorg Chem 2022 Apr 13;124:105808. Epub 2022 Apr 13.

Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig 44519, Egypt. Electronic address:

In an attempt to obtain new candidates with potential anti-inflammatory activity, two series of 1,3,4-oxadiazole based derivatives (8a-g) and 1,2,4-triazole based derivatives (10a,b and 11a-g) were synthesized and evaluated for their COX-1/COX-2 inhibitory activity. In vitro assays showed potent COX-2 inhibitory activity and selectivity of the novel designed compounds (IC = 0.04 - 0. Read More

View Article and Full-Text PDF

Biaxial Murine Vaginal Remodeling With Reproductive Aging.

J Biomech Eng 2022 Jun;144(6)

Department of Biomedical Engineering, Tulane University, 6823 St Charles Ave, New Orleans, LA 70118.

Higher reproductive age is associated with an increased risk of gestational diabetes, pre-eclampsia, and severe vaginal tearing during delivery. Further, menopause is associated with vaginal stiffening. However, the mechanical properties of the vagina during reproductive aging before the onset of menopause are unknown. Read More

View Article and Full-Text PDF

Network pharmacology and in vitro testing of Theobroma cacao extract's antioxidative activity and its effects on cancer cell survival.

PLoS One 2022 14;17(4):e0259757. Epub 2022 Apr 14.

Indian Council of Medical Research- National Institute of Traditional Medicine, Belagavi, Karnataka, India.

Theobroma cacao L. is a commercially important food/beverage and is used as traditional medicine worldwide against a variety of ailments. In the present study, computational biology approaches were implemented to elucidate the possible role of cocoa in cancer therapy. Read More

View Article and Full-Text PDF

The Therapeutic Effect and the Possible Mechanism of C-Phycocyanin in Lipopolysaccharide and Seawater-Induced Acute Lung Injury.

Drug Des Devel Ther 2022 6;16:1025-1040. Epub 2022 Apr 6.

Zhejiang Provincial Engineering Technology Research Center of Marine Biomedical Products, School of Food and Pharmacy, Zhejiang Ocean University, Zhoushan, 316022, People's Republic of China.

Background: Seawater drowning-induced acute lung injury (ALI) is a severe clinical condition characterized by increased alveolar-capillary permeability, excessive inflammatory response, and refractory hypoxemia. C-phycocyanin (C-PC), a biliprotein found in blue-green algae such as spirulina platensis, is widely used in the food and dietary nutritional supplement fields due to its beneficial pharmacological effects. Previous studies have revealed that C-PC has anti-inflammatory, antioxidant, and anti-apoptotic activities. Read More

View Article and Full-Text PDF

Enhanced Walking-Induced Fat Oxidation by New Zealand Blackcurrant Extract Is Body Composition-Dependent in Recreationally Active Adult Females.

Nutrients 2022 Apr 1;14(7). Epub 2022 Apr 1.

Institute of Sport, Nursing and Allied Health, College Lane, University of Chichester, Chichester PO19 6PE, UK.

New Zealand blackcurrant (NZBC) extract enhanced cycling-induced fat oxidation in female endurance athletes. We examined in recreationally active females the effects of NZBC extract on physiological and metabolic responses by moderate-intensity walking and the relationship of fat oxidation changes with focus on body composition parameters. Twelve females (age: 21 ± 2 y, BMI: 23. Read More

View Article and Full-Text PDF

High-intensity intermittent exercise induces a potential anti-inflammatory response in healthy women across the menstrual cycle.

Cytokine 2022 Jun 8;154:155872. Epub 2022 Apr 8.

Exercise and Immunometabolism Research Group, Postgraduation Program in Movement Sciences, Department of Physical Education, Universidade Estadual Paulista (UNESP), Presidente Prudente, Brazil; Laboratory of Physiology and Sport Performance (LAFIDE), Post-Graduate Program in Movement Sciences, São Paulo State University (UNESP), School of Sciences, Bauru, SP, Brazil; Facultad de Deportes Campus Ensenada, Universidad Autónoma de Baja California, Mexico. Electronic address:

Aim: This observational study aimed to examine cytokine responses to high-intensity intermittent exercise (HIIE) in the follicular and luteal phases of the menstrual cycle.

Methods: Fourteen healthy women (24 ± 2 years; body mass index [BMI]: 22.8 ± 1. Read More

View Article and Full-Text PDF

Nanoparticles Promote Bacterial Antibiotic Tolerance via Inducing Hyperosmotic Stress Response.

Small 2022 May 10;18(19):e2105525. Epub 2022 Apr 10.

The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei MOST) & Key Laboratory of Oral Biomedicine Ministry of Education School & Hospital of Stomatology, Wuhan University, Wuhan, 430079, China.

With the rapid development of nanotechnology, nanoparticles (NPs) are widely used in all fields of life. Nowadays, NPs have shown extraordinary antimicrobial activities and become one of the most popular strategies to combat antibiotic resistance. Whether they are equally effective in combating bacterial persistence, another important reason leading to antibiotic treatment failure, remains unknown. Read More

View Article and Full-Text PDF

Human IPSC 3D brain model as a tool to study chemical-induced dopaminergic neuronal toxicity.

Neurobiol Dis 2022 Jul 7;169:105719. Epub 2022 Apr 7.

Center for Alternative to Animal Testing, Johns Hopkins University, 615 North Wolfe St., Baltimore, MD 21205, United States of America.

Oxidative stress is caused by an imbalance between the generation and detoxification of reactive oxygen and nitrogen species (ROS/RNS). This imbalance plays an important role in brain aging and age-related neurodegenerative diseases. In the context of Parkinson's disease (PD), the sensitivity of dopaminergic neurons in the substantia nigra pars compacta to oxidative stress is considered a key factor of PD pathogenesis. Read More

View Article and Full-Text PDF

Assessing the aneurysm occlusion efficacy of a shear-thinning biomaterial in a 3D-printed model.

J Mech Behav Biomed Mater 2022 06 18;130:105156. Epub 2022 Mar 18.

Department of Bioengineering, University of California, Los Angeles, 410 Westwood Plaza, Los Angeles, CA, 90095, USA; California NanoSystems Institute (CNSI), University of California, Los Angeles, 570 Westwood Plaza, Los Angeles, CA, 90095, USA; Department of Chemical Engineering, The Pennsylvania State University, University Park, PA, 16802, USA; Department of Biomedical Engineering, The Pennsylvania State University, University Park, PA, 16802, USA. Electronic address:

Metallic coil embolization is a common method for the endovascular treatment of visceral artery aneurysms (VAA) and visceral artery pseudoaneurysms (VAPA); however, this treatment is suboptimal due to the high cost of coils, incomplete volume occlusion, poor reendothelialization, aneurysm puncture, and coil migration. Several alternative treatment strategies are available, including stent flow diverters, glue embolics, gelfoam slurries, and vascular mesh plugs-each of which have their own disadvantages. Here, we investigated the in vitro capability of a shear-thinning biomaterial (STB), a nanocomposite hydrogel composed of gelatin and silicate nanoplatelets, for the minimally-invasive occlusion of simple necked aneurysm models. Read More

View Article and Full-Text PDF

Crocin Alleviates Intracerebral Hemorrhage-Induced Neuronal Ferroptosis by Facilitating Nrf2 Nuclear Translocation.

Neurotox Res 2022 Apr 5;40(2):596-604. Epub 2022 Apr 5.

Department of Critical Care Medicine, Jiading District Central Hospital Affiliated Shanghai University of Medicine & Health Sciences, No. 1, Chengbei Rd, Jiading District, Shanghai, China.

Intracerebral hemorrhage (ICH) is the deadliest type of stroke. Oxidative stress was considered to play an important role in ICH-induced secondary injury. Crocin, the main compound isolated from Crocus sativus L. Read More

View Article and Full-Text PDF

Pharmacology Management in Improving Exercise Capacity of Patients with Fontan Circulation: A Systematic Review and Meta-Analysis.

Curr Cardiol Rev 2022 Apr 4. Epub 2022 Apr 4.

Pediatric Cardiology and Congenital Heart Defect Division, Department of Cardiology and Vascular Medicine, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia.

Background: The Fontan procedure is currently the mainstay therapy for single functional ventricles. However, with prolonged follow-up duration, various complications have been observed that seriously influence the quality of life of patients.

Objectives: The aim of this meta-analysis is to compare the effectiveness of pharmacologic agents in improving exercise capacity in patients with Fontan circulation. Read More

View Article and Full-Text PDF