9,158 results match your criteria Pharmacologic Stress Testing


International Triadin Knockout Syndrome Registry: The Clinical Phenotype and Treatment Outcomes of Patients with Triadin Knockout Syndrome.

Circ Genom Precis Med 2019 Jan 16. Epub 2019 Jan 16.

Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN.

Background: Triadin knockout syndrome (TKOS) is a rare, inherited arrhythmia syndrome caused by recessive null mutations in TRDN-encoded cardiac triadin. Based previously on five TRDN null patients, TKOS has been characterized by extensive T-wave inversions, transient QT prolongation, and severe disease expression of exercise-induced cardiac arrest in early childhood refractory to conventional therapy.

Methods: We have established the International Triadin Knockout Syndrome Registry (ITKOSR) to include patients who have genetically proven homozygous/compound heterozygous TRDN null mutations. Read More

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http://dx.doi.org/10.1161/CIRCGEN.118.002419DOI Listing
January 2019

Resilience characteristics and prior life stress determine anticipatory response to acute social stress in children aged 7-11 years.

Br J Health Psychol 2019 Jan 13. Epub 2019 Jan 13.

Department of Health, University of Bath, UK.

Objectives: To assess the interplay of prior life stress and characteristics of resilience in determining how children cope with potentially stressful situations, using a two-phase study that triangulates parent-child dyadic interview data with subsequent experience of an acute laboratory stressor in 7-11-year-olds.

Methods: Participants (n = 34) were designated as being in one of four groups based on high/low levels of prior stress experience and high/low resilience ratings assessed during at-home interviews and from questionnaires measuring recent life events, hassles, and trait coping. During a subsequent laboratory stress protocol, salivary cortisol and heart rate were monitored, and a verbal subjective report was provided. Read More

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http://dx.doi.org/10.1111/bjhp.12353DOI Listing
January 2019

SR Ca leak in skeletal muscle fibers acts as an intracellular signal to increase fatigue resistance.

J Gen Physiol 2019 Jan 11. Epub 2019 Jan 11.

Department of Physiology and Pharmacology, Biomedicum C5, Karolinska Institutet, Stockholm, Sweden

Effective practices to improve skeletal muscle fatigue resistance are crucial for athletes as well as patients with dysfunctional muscles. To this end, it is important to identify the cellular signaling pathway that triggers mitochondrial biogenesis and thereby increases oxidative capacity and fatigue resistance in skeletal muscle fibers. Here, we test the hypothesis that the stress induced in skeletal muscle fibers by endurance exercise causes a reduction in the association of FK506-binding protein 12 (FKBP12) with ryanodine receptor 1 (RYR1). Read More

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http://www.jgp.org/lookup/doi/10.1085/jgp.201812152
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http://dx.doi.org/10.1085/jgp.201812152DOI Listing
January 2019
7 Reads

Women Experience the Same Ergogenic Response to Caffeine as Men.

Med Sci Sports Exerc 2019 Jan 8. Epub 2019 Jan 8.

School of Human Movement and Nutrition Sciences, The University of Queensland, Australia.

Purpose: This study aimed to determine if 1) consumption of caffeine improves endurance cycling performance in women, and 2) sex differences exist in the magnitude of the ergogenic and plasma responses to caffeine supplementation.

Methods: Twenty-seven (11 women and 16 men) endurance-trained cyclists and triathletes participated in this randomized, double-blind, placebo-controlled, crossover study. Participants completed an incremental exercise test to exhaustion, two familiarization trials and two performance trials. Read More

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http://dx.doi.org/10.1249/MSS.0000000000001885DOI Listing
January 2019

Short-Term Environmental Stimulation Spatiotemporally Modulates Specific Serotonin Receptor Gene Expression and Behavioral Pharmacology in a Sexually Dimorphic Manner in Huntington's Disease Transgenic Mice.

Front Mol Neurosci 2018 10;11:433. Epub 2018 Dec 10.

Florey Institute of Neuroscience and Mental Health, Melbourne Brain Centre, University of Melbourne, Parkville, VIC, Australia.

Huntington's disease (HD) is a neurodegenerative disorder caused by a tandem repeat mutation encoding an expanded polyglutamine tract in the huntingtin protein, which leads to cognitive, psychiatric and motor dysfunction. Exposure to environmental enrichment (EE), which enhances levels of cognitive stimulation and physical activity, has therapeutic effects on cognitive, affective and motor function of transgenic HD mice. The present study investigated gene expression changes and behavioral pharmacology in male and female R6/1 transgenic HD mice at an early time-point in HD progression associated with onset of cognitive and affective abnormalities, following EE and exercise (wheel running) interventions. Read More

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http://dx.doi.org/10.3389/fnmol.2018.00433DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295568PMC
December 2018
2 Reads

Effects of caffeine ingestion on the diurnal variation of cognitive and repeated high-intensity performances.

Pharmacol Biochem Behav 2019 Jan 3;177:69-74. Epub 2019 Jan 3.

Institut Supérieur du Sport et de l'Education Physique de Sfax, Université de Sfax, Tunisie; Activité Physique: Sport et Santé, UR18JS01, Observatoire National du Sport, Tunis, Tunisie.

The purpose of this study was to evaluate the effects of caffeine ingestion on the daily variation of cognitive (i.e., reaction time (RT), attention) and repeated high-intensity exercise performances. Read More

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http://dx.doi.org/10.1016/j.pbb.2019.01.001DOI Listing
January 2019

Pterostilbene, an active component of the dragon's blood extract, acts as an antidepressant in adult rats.

Psychopharmacology (Berl) 2019 Jan 4. Epub 2019 Jan 4.

School of Life Science, Beijing Institute of Technology, Beijing, 100081, People's Republic of China.

Background: Hippocampal neurogenesis has been widely considered as one of the potential biological mechanisms for the treatment of depression caused by chronic stress. Many natural products have been reported to be beneficial for neurogenesis.

Objectives: The present study is designed to investigate the effect of dragon's blood extract (DBE) and its biologically active compound, pterostilbene (PTE), on hippocampal neurogenesis. Read More

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http://dx.doi.org/10.1007/s00213-018-5138-7DOI Listing
January 2019
3.875 Impact Factor

Tempering aversive/traumatic memories with cannabinoids: a review of evidence from animal and human studies.

Psychopharmacology (Berl) 2019 Jan 2. Epub 2019 Jan 2.

Department of Pharmacology, Medical School of Ribeirão Preto, University of São Paulo (FMRP/USP), Av Bandeirantes 3900, Monte Alegre, 14049900, Ribeirão Preto, São Paulo, Brazil.

Rationale: Aversive learning and memory are essential to cope with dangerous and stressful stimuli present in an ever-changing environment. When this process is dysfunctional, however, it is associated with posttraumatic stress disorder (PTSD). The endocannabinoid (eCB) system has been implicated in synaptic plasticity associated with physiological and pathological aversive learning and memory. Read More

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http://dx.doi.org/10.1007/s00213-018-5127-xDOI Listing
January 2019
1 Read

Clinical correlates and outcome associated with changes in 6-minute walking distance in patients with heart failure: findings from the BIOSTAT-CHF study.

Eur J Heart Fail 2019 Jan 1. Epub 2019 Jan 1.

INSERM, Centre d'Investigations Cliniques Plurithématique 1433, Université de Lorraine, CHRU de Nancy and F-CRIN INI-CRCT, Nancy, France.

Background: The 6-minute walk test (6MWT) is a simple and inexpensive way of measuring exercise capacity in patients with heart failure (HF) that predicts morbidity and mortality. However, there are few reports from large multicentre cohorts assessing the predictive value of baseline and changing walk distance.

Methods And Results: In BIOSTAT-CHF, a 6MWT was performed at baseline (n = 1714) and 9 months (n = 1520). Read More

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http://doi.wiley.com/10.1002/ejhf.1380
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http://dx.doi.org/10.1002/ejhf.1380DOI Listing
January 2019
3 Reads
6.526 Impact Factor

Effects of Six-Month Aerobic Exercise Intervention on Sleep in Healthy Older Adults in the Study: A Pilot Study.

J Alzheimers Dis Rep 2018 Dec 24;2(1):229-238. Epub 2018 Dec 24.

Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.

Background: Sleep disturbances have been shown to be associated with the presence of the apolipoprotein () 4 allele, the well-known genetic risk factor for late-onset sporadic Alzheimer's disease (AD).

Objective: This study quantifies the effects of a six-month aerobic exercise intervention on objective and subjective sleep quality in middle-aged to older individuals including those at increased genetic risk for late-onset sporadic Alzheimer's disease (AD), who carry the apolipoprotein () 4 risk allele.

Methods: 199 sedentary men and women without significant cognitive impairments were enrolled in the study, a quasi-experimental single group pre-test/post-test study with no control group. Read More

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https://www.medra.org/servlet/aliasResolver?alias=iospress&a
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http://dx.doi.org/10.3233/ADR-180079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311349PMC
December 2018
1 Read

Veterans have greater variability in their perception of binocular alignment.

PLoS One 2018 26;13(12):e0209622. Epub 2018 Dec 26.

War Related Illness and Injury Study Center, Department of Veteran Affairs, NJ, United States of America.

Introduction: A significant population of our wounded veterans suffer long-term functional consequences of visual deficit, disorientation, dizziness, and an impaired ability to read. These symptoms may be related to damage within the otolith pathways that contribute to ocular alignment. The purpose of this study was to compare perception of vertical and torsional ocular alignment between veterans and healthy controls in an upright and supine test position. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0209622PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306227PMC
December 2018
2 Reads

Comparing effects of 4 months of two self-administered exercise training programs on physical performance in patients with chronic kidney disease: RENEXC - A randomized controlled trial.

PLoS One 2018 20;13(12):e0207349. Epub 2018 Dec 20.

Department of Nephrology, Institution of Clinical Sciences, Faculty of Medicine, Lund University, Skåne University Hospital, Lund, Sweden.

Background: Exercise training is recommended to patients with chronic kidney disease (CKD). However, the level of evidence is still low. This randomized controlled trial (RCT) compared two different and self-administered exercise training programs in a representative CKD population. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0207349PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6301660PMC
December 2018

Safely Identifying Emergency Department Patients With Acute Chest Pain for Early Discharge.

Circulation 2018 Nov;138(22):2456-2468

Department of Emergency Medicine (S.A.M., B.C.H., C.D.M.), Wake Forest School of Medicine, Winston-Salem, NC.

Background: The HEART Pathway (history, ECG, age, risk factors, and initial troponin) is an accelerated diagnostic protocol designed to identify low-risk emergency department patients with chest pain for early discharge without stress testing or angiography. The objective of this study was to determine whether implementation of the HEART Pathway is safe (30-day death and myocardial infarction rate <1% in low-risk patients) and effective (reduces 30-day hospitalizations) in emergency department patients with possible acute coronary syndrome.

Methods: A prospective pre-post study was conducted at 3 US sites among 8474 adult emergency department patients with possible acute coronary syndrome. Read More

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.036528DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309794PMC
November 2018
3 Reads

Molecular adaptations in human subcutaneous adipose tissue after ten weeks of endurance exercise training in healthy males.

J Appl Physiol (1985) 2018 Dec 20. Epub 2018 Dec 20.

Department of Biomedicine, Aarhus University Hospital, Denmark.

Endurance exercise training induces adaptations in metabolically active organs, but adaptations in human subcutaneous adipose tissue (scAT) remains incompletely understood. Based on animal studies, we hypothesized that endurance exercise training would increase the expression of proteins involved in lipolysis and glucose uptake in scAT. To test these hypotheses, nineteen young and healthy males were randomized to either endurance exercise training (TR; age 18-24 yr; BMI 19. Read More

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http://dx.doi.org/10.1152/japplphysiol.00989.2018DOI Listing
December 2018

Study of Myocardial Perfusion in Obese Individuals without Known Ischemic Heart Disease.

Arq Bras Cardiol 2018 Dec 17. Epub 2018 Dec 17.

Clínica Quanta Diagnóstico e Terapia, Curitiba, PR - Brazil.

Background: Obesity is associated with an increased risk of type 2 diabetes mellitus (DM), ischemic heart disease (IHD) and cardiovascular mortality. Several studies have demonstrated the diagnostic and prognostic value of single photon computed tomography-myocardial perfusion scintigraphy (SPECT-MPI) in the evaluation of patients with suspected IHD, including in obese population. Data on clinical risk factors and their association with abnormal myocardial perfusion in obese patients are scarce in the Brazilian population. Read More

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http://www.gnresearch.org/doi/10.5935/abc.20180250
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http://dx.doi.org/10.5935/abc.20180250DOI Listing
December 2018
8 Reads

Human kidney on a chip assessment of polymyxin antibiotic nephrotoxicity.

JCI Insight 2018 Dec 20;3(24). Epub 2018 Dec 20.

Department of Pharmaceutics.

Drug-induced kidney injury, largely caused by proximal tubular intoxicants, limits development and clinical use of new and approved drugs. Assessing preclinical nephrotoxicity relies on animal models that are frequently insensitive; thus, potentially novel techniques - including human microphysiological systems, or "organs on chips" - are proposed to accelerate drug development and predict safety. Polymyxins are potent antibiotics against multidrug-resistant microorganisms; however, clinical use remains restricted because of high risk of nephrotoxicity and limited understanding of toxicological mechanisms. Read More

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http://dx.doi.org/10.1172/jci.insight.123673DOI Listing
December 2018
5 Reads

Plasma asymmetric dimethylarginine concentrations are not related to differences in maximal oxygen uptake in endurance trained and untrained men.

Exp Physiol 2018 Nov 22. Epub 2018 Nov 22.

University of Lille, University of Artois, University of Littoral Côte, d'Opale, EA 7369 - URePSSS, Pluridisciplinary Research Unit, "Sport, Health and Society", F-59000, Lille, France.

New Findings: What is the central question of this study? Is there an association of plasma concentration of asymmetric dimethylarginine, which is related to exercise capacity in patients with cardiovascular diseases, with oxygen delivery and subsequently exercise capacity in healthy subjects in the absence of the potentially confounding influence of inflammation and oxidative stress? What is the main finding and its importance? Plasma asymmetric dimethylarginine concentrations are not related to exercise capacity in healthy subjects, while O delivery in the working skeletal muscle during the maximal graded-exercise test is not associated with any of the l-arginine analogues. ADMA alone does not play a crucial role in local muscle perfusion and in maintaining exercise capacity.

Abstract: Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide (NO) synthesis that could limit oxygen (O ) delivery in the working skeletal muscles by altering endothelium-dependent vasodilatation. Read More

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http://dx.doi.org/10.1113/EP087398DOI Listing
November 2018

Kaempferol attenuates diabetic nephropathy by inhibiting RhoA/Rho-kinase mediated inflammatory signalling.

Biomed Pharmacother 2019 Jan 15;109:1610-1619. Epub 2018 Nov 15.

Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER)-Ahmedabad, Gandhinagar, 382355, Gujarat, India; Department of Biotechnology, National Institute of Pharmaceutical Education and Research (NIPER)-Ahmedabad, Gandhinagar, 382355, Gujarat, India. Electronic address:

RhoA/Rho-associated coiled-coil forming protein serine/threonine kinase (ROCK) has appeared as a potential therapeutic target in numerous diseases, because of its preventing action on various enzymes providing antioxidant and cytoprotective action. Progression and pathophysiology of diabetic nephropathy have also shown potential involvement of oxidative stress and inflammatory pathways. In the present study, we investigated the effect of kaempferol on hyperglycemia-induced activation of RhoA kinase and associated inflammatory signaling cascade. Read More

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http://dx.doi.org/10.1016/j.biopha.2018.10.195DOI Listing
January 2019

A Novel, Synthetic, Neuroactive Steroid Is Effective at Decreasing Depression-Like Behaviors and Improving Maternal Care in Preclinical Models of Postpartum Depression.

Front Endocrinol (Lausanne) 2018 23;9:703. Epub 2018 Nov 23.

Neuroscience Department, Tufts University School of Medicine, Boston, MA, United States.

Preclinical testing of treatments for postpartum depression (PPD) has been limited due to the lack of available animal models of such a complex disorder. To address this limitation, our laboratory has generated unique preclinical mouse models that exhibit abnormal postpartum behaviors. Mice with a loss or reduction in the expression of the GABA receptor (GABAR) δ subunit ( or , respectively) and mice that lack the K/Cl co-transporter, KCC2, specifically in corticotropin-releasing hormone (CRH) neurons (KCC2/Crh mice) exhibit depression-like behaviors restricted to the postpartum period and deficits in maternal care, which serve as useful tools for testing novel therapeutic compounds. Read More

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http://dx.doi.org/10.3389/fendo.2018.00703DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6265503PMC
November 2018

The 18 kDa Translocator Protein (TSPO) Overexpression in Hippocampal Dentate Gyrus Elicits Anxiolytic-Like Effects in a Mouse Model of Post-traumatic Stress Disorder.

Front Pharmacol 2018 23;9:1364. Epub 2018 Nov 23.

State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, Beijing, China.

The translocator protein (18 kDa) (TSPO) recently attracted increasing attention in the pathogenesis of post-traumatic stress disorder (PTSD). This study is testing the hypothesis that the overexpression of TSPO in hippocampus dentate gyrus (DG) could alleviate the anxiogenic-like response in the mice model of PTSD induced by foot-shock. In this study, hippocampal DG overexpression of TSPO significantly reversed the increase of the contextual freezing response, the decrease of the percentage of both entries into and time spent in the open arms in elevated plus maze test and the decrease of the account of crossings from the dark to light compartments in light-dark transition test induced by electric foot-shocks procedure. Read More

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http://dx.doi.org/10.3389/fphar.2018.01364DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6265405PMC
November 2018

Haemodynamic effects of pharmacologic stress with adenosine in patients with left ventricular systolic dysfunction.

Int J Cardiol 2018 Dec 4. Epub 2018 Dec 4.

Department of Cardiovascular Sciences, University of Leicester and the NIHR Biomedical Research Centre, Glenfield Hospital, Groby Road, Leicester LE3 9QP, UK. Electronic address:

Background: In patients with heart failure, downregulation of adenosine receptor gene expression and impaired adenosine-related signal transduction may result in a diminished response to adenosine. This may have implications for cardiac stress testing. We evaluated the haemodynamic response to intravenous adenosine in patients with left ventricular systolic dysfunction (LVSD) undergoing stress cardiovascular magnetic resonance imaging (CMR). Read More

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http://dx.doi.org/10.1016/j.ijcard.2018.12.006DOI Listing
December 2018
4.036 Impact Factor

Finite Element Analysis of the Mouse Distal Femur with Tumor Burden in Response to Knee Loading.

Int J Orthop (Hong Kong) 2018 28;5(1):863-871. Epub 2018 Feb 28.

Department of Mechanical Engineering, Indiana University Purdue University Indianapolis, Indianapolis, IN 46202, USA.

Breast cancer-associated bone metastasis induces bone loss, followed by an increased risk of bone fracture. To develop a strategy for preventing tumor growth and protecting bone, an understanding of the mechanical properties of bone under tumor burden is indispensable. Using a mouse model of mammary tumor, we conducted finite element analysis (FEA) of two bone samples from the distal femur. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261479PMC
February 2018
6 Reads

A systematic comparison of exercise training protocols on animal models of cardiovascular capacity.

Life Sci 2019 Jan 3;217:128-140. Epub 2018 Dec 3.

National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest of China/CGDB, Shaanxi Normal University College of Life Sciences, Xi'an 710119, China. Electronic address:

Cardiovascular disease (CVD) is a major global cause of mortality, which has prompted numerous studies seeking to reduce the risk of heart failure and sudden cardiac death. While regular physical activity is known to improve CVD associated morbidity and mortality, the optimal duration, frequency, and intensity of exercise remains unclear. To address this uncertainty, various animal models have been used to study the cardioprotective effects of exercise and related molecular mechanism such as the mice training models significantly decrease size of myocardial infarct by affecting Kir6. Read More

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http://dx.doi.org/10.1016/j.lfs.2018.12.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320317PMC
January 2019
2 Reads
2.702 Impact Factor

Influence of weight loss on pulmonary function and levels of adipokines among asthmatic individuals with obesity: One-year follow-up.

Respir Med 2018 Dec 21;145:48-56. Epub 2018 Oct 21.

Department of Surgery, Faculty of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil.

Background: Individuals with obesity are more likely to develop asthma, but the exact mechanism is still uncertain and several hypotheses have been raised, such as the release of inflammatory mediators secreted by adipose tissue.

Objective: To assess the effects of weight loss in patients submitted to bariatric surgery on pulmonary and systemic inflammation.

Method: The study evaluated patients undergoing bariatric surgery (Roux-en-Y gastric bypass) with the diagnosis of asthma, except smokers. Read More

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http://dx.doi.org/10.1016/j.rmed.2018.10.017DOI Listing
December 2018
2 Reads

Neuroplasticity-related correlates of environmental enrichment combined with physical activity differ between the sexes.

Eur Neuropsychopharmacol 2018 Nov 26. Epub 2018 Nov 26.

Department of Pharmacology, Medical School, National and Kapodistrian University of Athens, Mikras Asias 75, Athens 11527, Greece. Electronic address:

Environmental enrichment (EE), comprising positive physical (exercise) and cognitive stimuli, influences neuronal structure and usually improves brain function. The promise of EE as a preventative strategy against neuropsychiatric disease is especially high during early postnatal development when the brain is still amenable to reorganization. Despite the fact that male and female brains differ in terms of connectivity and function that may reflect early life experiences, knowledge of the neural substrates and mechanisms by which such changes arise remains limited. Read More

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http://dx.doi.org/10.1016/j.euroneuro.2018.11.1107DOI Listing
November 2018

Dosimetry, biodistribution, and safety of flurpiridaz F 18 in healthy subjects undergoing rest and exercise or pharmacological stress PET myocardial perfusion imaging.

J Nucl Cardiol 2018 Nov 28. Epub 2018 Nov 28.

Lantheus Medical Imaging, Billerica, MA, USA.

The objectives of this study were to evaluate radiation dosimetry, biodistribution, human safety, and tolerability of F-labeled flurpiridaz (Flurpiridaz) in normal subjects undergoing rest and separate-day exercise or adenosine pharmacological stress PET imaging.

Methods: 12 normal subjects were injected with 58.5 to 121 MBq (1. Read More

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http://dx.doi.org/10.1007/s12350-018-01484-zDOI Listing
November 2018
5 Reads

Safety of regadenoson positon emission tomography stress testing in orthotopic heart transplant patients.

J Nucl Cardiol 2018 Nov 27. Epub 2018 Nov 27.

University of Michigan Frankel Cardiovascular Center, 1500 East Medical Center Drive, Ann Arbor, MI, 48109-5853, USA.

Objectives: We sought to determine the safety of regadenoson (REG) stress testing in patients who have undergone orthotopic heart transplantation (OHT).

Background: Routine screening for cardiac allograft vasculopathy (CAV) is necessary after OHT. Adenosine stress is contraindicated after heart transplantation due to supersensitivity in denervated hearts. Read More

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http://dx.doi.org/10.1007/s12350-018-01466-1DOI Listing
November 2018
1 Read

Extinction of Fear Memory Attenuates Conditioned Cardiovascular Fear Reactivity.

Front Behav Neurosci 2018 13;12:276. Epub 2018 Nov 13.

Department of Pharmacology and Physiology and Institute for Neuroscience, George Washington University, Washington, DC, United States.

Post-traumatic stress disorder (PTSD) is characterized by a heightened emotional and physiological state and an impaired ability to suppress or extinguish traumatic fear memories. Exaggerated physiological responses may contribute to increased cardiovascular disease (CVD) risk in this population, but whether treatment for PTSD can offset CVD risk remains unknown. To further evaluate physiological correlates of fear learning, we used a novel pre-clinical conditioned cardiovascular testing paradigm and examined the effects of Pavlovian fear conditioning and extinction training on mean arterial pressure (MAP) and heart rate (HR) responses. Read More

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https://www.frontiersin.org/article/10.3389/fnbeh.2018.00276
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http://dx.doi.org/10.3389/fnbeh.2018.00276DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6244092PMC
November 2018
5 Reads

Anxiolytic effects of γ-oryzanol in chronically- stressed mice are related to monoamine levels in the brain.

Life Sci 2019 Jan 20;216:119-128. Epub 2018 Nov 20.

Laboratory of Physiology and Pharmacology, School of Advanced Science and Engineering, Waseda University, Tokyo, Japan. Electronic address:

Aims: The present study was aimed to investigate the anxiolytic effect of γ-oryzanol (GORZ) during chronic restraint stress treatment (CRST), which is a well-documented model of stress-related disorders, like anxiety, and its potential molecular mechanisms.

Materials And Methods: In this experiment, 5-week-old male ICR mice were used and the concentration of GORZ was fixed at 0.5% in the mouse standard diet (14% casein, AIN 93 M). Read More

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http://dx.doi.org/10.1016/j.lfs.2018.11.042DOI Listing
January 2019
4 Reads

Balance and mobility in patients with newly diagnosed Parkinson's disease - a five-year follow-up of a cohort in northern Sweden.

Disabil Rehabil 2018 Nov 19:1-10. Epub 2018 Nov 19.

a Department of Community Medicine and Rehabilitation; Physiotherapy , Umeå University , Umeå , Sweden.

Background: The presence of early balance impairment in patients with Parkinson's disease has not been fully investigated.

Purpose: The purpose of this study was to examine balance and mobility, self-perceived unsteadiness, self-reported falls, and effects of medication on balance among patients at their first visit to a neurological clinic and during the ensuing five years.

Materials And Methods: The participants were collected from a prospective longitudinal study. Read More

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http://dx.doi.org/10.1080/09638288.2018.1509240DOI Listing
November 2018
7 Reads

Effects of Probiotic Supplementation on Selected Parameters of Blood Prooxidant-Antioxidant Balance in Elite Athletes: A Double-Blind Randomized Placebo-Controlled Study.

J Hum Kinet 2018 Sep 15;64:111-122. Epub 2018 Oct 15.

Department of Bromatology, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia.

A randomized, double-blind, placebo-controlled study was conducted, in order to evaluate if Lactobacillus helveticus Lafti® L10 (Lallemand Health Solutions, Montreal, Canada) supplementation during three months could influence oxidative markers in the population of elite athletes: triathletes, cyclists and endurance athletes. Twenty-two elite athletes were randomized to either placebo (n = 12) or probiotic (n = 10) groups. The probiotic group received 2x1010 colony forming units of Lafti® L10. Read More

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https://content.sciendo.com/view/journals/hukin/64/1/article
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http://dx.doi.org/10.1515/hukin-2017-0203DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6231349PMC
September 2018
14 Reads

Growth Factor and Intense Pulse Light in Flexor Tendon Repair: A Biomechanical Study at Strength and Gap Resistance.

J Hand Surg Asian Pac Vol 2018 Dec;23(4):463-468

† School of Biochemistry, Swansea University, Swansea, UK.

Background: Flexor tendon injuries are extremely common and they are usually the result of incised traumatic glass or knife injury. The process of tendon healing is a complicated and exceptionally-regimented mechanism that is originated and monitored by a vast number of diverse molecules. One of the most pivotal groups of mediators that are crucial to the healing process are growth factors (GF). Read More

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http://dx.doi.org/10.1142/S2424835518500431DOI Listing
December 2018

Effect of Inorganic Nitrite vs Placebo on Exercise Capacity Among Patients With Heart Failure With Preserved Ejection Fraction: The INDIE-HFpEF Randomized Clinical Trial.

JAMA 2018 11;320(17):1764-1773

Mayo Clinic, Rochester, Minnesota.

Importance: There are few effective treatments for heart failure with preserved ejection fraction (HFpEF). Short-term administration of inorganic nitrite or nitrate preparations has been shown to enhance nitric oxide signaling, which may improve aerobic capacity in HFpEF.

Objective: To determine the effect of 4 weeks' administration of inhaled, nebulized inorganic nitrite on exercise capacity in HFpEF. Read More

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http://jama.jamanetwork.com/article.aspx?doi=10.1001/jama.20
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http://dx.doi.org/10.1001/jama.2018.14852DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6248105PMC
November 2018
16 Reads

Use of High-Sensitivity Cardiac Troponin for the Exclusion of Inducible Myocardial Ischemia: A Cohort Study.

Ann Intern Med 2018 Dec 6;169(11):751-760. Epub 2018 Nov 6.

Emory University School of Medicine, Atlanta, Georgia (M.H., J.H.K., A.S.T., B.K., C.L., I.A., K.W., R.R., A.A., F.C., M.M.G., N.A., P.S., B.B.L., J.D.B., L.S.S., A.A.Q.).

Background: Many patients with coronary artery disease (CAD) are routinely referred for surveillance stress testing despite recommendations against it.

Objective: To determine whether low levels of resting high-sensitivity cardiac troponin I (hs-cTnI) can identify persons without inducible myocardial ischemia.

Design: Observational study. Read More

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http://annals.org/article.aspx?doi=10.7326/M18-0670
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http://dx.doi.org/10.7326/M18-0670DOI Listing
December 2018
8 Reads

Healthy hearts in pediatric heart transplant patients with an exercise and diet intervention via live video conferencing-Design and rationale.

Pediatr Transplant 2018 Nov 4:e13316. Epub 2018 Nov 4.

Division of Pediatric Cardiology, Department of Pediatrics, Stanford University Medical Center, Palo Alto, California.

Background: Pediatric heart transplant (PedHtx) patients have increased cardiovascular risk profiles that affect their long-term outcomes and quality of life. We designed a 12- to 16-week diet and exercise intervention delivered via live video conferencing to improve cardiovascular health. Our methodology and baseline assessment of the first 13 enrolled patients are reported. Read More

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http://doi.wiley.com/10.1111/petr.13316
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http://dx.doi.org/10.1111/petr.13316DOI Listing
November 2018
11 Reads
1.630 Impact Factor

6-shogaol protects against diabetic nephropathy and cardiomyopathy via modulation of oxidative stress/NF-κB pathway.

Pak J Pharm Sci 2018 Sep;31(5(Supplementary)):2109-2117

Department of Pharmacognosy, College of Pharmacy, Umm Al-Qura University, Makkah, Saudi Arabia.

Diabetes dramatically increases the risk of numerous heart and kidney troubles. Diabetic nephropathy (DN) and cardiomyopathy (DC) are major causes of death. The pathophysiology of DN/DC includes inflammatory and oxidative stress mechanisms. Read More

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September 2018
8 Reads

Coronary computed tomographic imaging in women: An expert consensus statement from the Society of Cardiovascular Computed Tomography.

J Cardiovasc Comput Tomogr 2018 Nov - Dec;12(6):451-466. Epub 2018 Oct 23.

Weill Cornell Medicine, USA.

This expert consensus statement from the Society of Cardiovascular Computed Tomography (SCCT) provides an evidence synthesis on the use of computed tomography (CT) imaging for diagnosis and risk stratification of coronary artery disease in women. From large patient and population cohorts of asymptomatic women, detection of any coronary artery calcium that identifies females with a 10-year atherosclerotic cardiovascular disease risk of >7.5% may more effectively triage women who may benefit from pharmacologic therapy. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S19345925183043
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http://dx.doi.org/10.1016/j.jcct.2018.10.019DOI Listing
October 2018
6 Reads

Day-Night Oscillation of Atrogin1 and Timing-Dependent Preventive Effect of Weight-Bearing on Muscle Atrophy.

EBioMedicine 2018 Nov 1;37:499-508. Epub 2018 Nov 1.

Laboratory of Physiology and Pharmacology, School of Advanced Science and Engineering, Waseda University, Tokyo, Japan,. Electronic address:

Background: Atrogin1, which is one of the key genes for the promotion of muscle atrophy, exhibits day-night variation. However, its mechanism and the role of its day-night variation are largely unknown in a muscle atrophic context.

Methods: The mice were induced a muscle atrophy by hindlimb-unloading (HU). Read More

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http://dx.doi.org/10.1016/j.ebiom.2018.10.057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286653PMC
November 2018
3 Reads

Prolonged Sitting Interrupted by 6-Min of High-Intensity Exercise: Circulatory, Metabolic, Hormonal, Thermal, Cognitive, and Perceptual Responses.

Front Physiol 2018 16;9:1279. Epub 2018 Oct 16.

Institute of Sport Science, University of Würzburg, Würzburg, Germany.

The aim was to examine certain aspects of circulatory, metabolic, hormonal, thermoregulatory, cognitive, and perceptual responses while sitting following a brief session of high-intensity interval exercise. Twelve students (five men; age, 22 ± 2 years) performed two trials involving either simply sitting for 180 min (SIT) or sitting for this same period with a 6-min session of high-intensity exercise after 60 min (SIT+HIIT). At T (after 30 min of resting), T (after a 20-min breakfast), T (after sitting for 1 h), T (immediately after the HIIT), T, T, T, and T (30, 60, 90, and 120 min after the HIIT), circulatory, metabolic, hormonal, thermoregulatory, cognitive, and perceptual responses were assessed. Read More

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http://dx.doi.org/10.3389/fphys.2018.01279DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6198043PMC
October 2018
1 Read

Exercise Increases Adiponectin and Reduces Leptin Levels in Prediabetic and Diabetic Individuals: Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Med Sci (Basel) 2018 Oct 30;6(4). Epub 2018 Oct 30.

Department of Nutritional Sciences, Faculty of Life Sciences, University of Vienna, Althanstraβe 14, 1090 Vienna, Austria.

It is speculated that lifestyle interventions known to improve diabetic metabolic state may exert their effects via adipokines. The aim of this systematic review and meta-analysis was to evaluate the chronic effects of physical exercise on adiponectin and leptin levels in adult prediabetic and diabetic individuals. PubMed, Embase, Scopus, The Cochrane Library, clinicaltrials. Read More

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http://dx.doi.org/10.3390/medsci6040097DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318757PMC
October 2018

Application of Single Prolonged Stress Induces Post-traumatic Stress Disorder-like Characteristics in Mice.

Acta Med Okayama 2018 Oct;72(5):479-485

Physiology and Pharmacology, School of Health and Social Services, Saitama Prefectural University, Koshigaya, Saitama 343-8540, Japan.

We tried to clarify the applicability of a single prolonged stress (SPS) protocol as post-traumatic stress disorder (PTSD) model in mice. To investigate PTSD pathophysiology, we conducted hypothalamo-pituitary-adrenal (HPA) negative feedback testing at 1, 4, 8 and 12 weeks after the SPS by administrating a dexamethasone (DEX) suppression test. The SPS induced over-suppression of the HPA system by DEX treatment at 8 and 12 weeks. Read More

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http://dx.doi.org/10.18926/AMO/56245DOI Listing
October 2018
1 Read

Selective modulator of peroxisome proliferator-activated receptor-α protects propionic acid induced autism-like phenotypes in rats.

Life Sci 2018 Dec 23;214:106-117. Epub 2018 Oct 23.

Department of Pharmacology, Amity Institute of Pharmacy, Amity University Uttar Pradesh, India; CNS Pharmacology, Conscience Research, Delhi, India. Electronic address:

Aims: The present study investigated the neuropharmacological role of PPAR-α modulator, fenofibrate in postnatal-propionic acid induced symptomatology related with autism spectrum disorders (ASD) in Wistar rats.

Main Methods: The propionic acid (250 mg/kg, p.o. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00243205183067
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http://dx.doi.org/10.1016/j.lfs.2018.10.045DOI Listing
December 2018
7 Reads
2.702 Impact Factor

ERS technical standard on bronchial challenge testing: pathophysiology and methodology of indirect airway challenge testing.

Eur Respir J 2018 Nov 15;52(5). Epub 2018 Nov 15.

Pulmonary Function Testing and Clinical Trials Consultant, Rochester, MN, USA.

Recently, this international task force reported the general considerations for bronchial challenge testing and the performance of the methacholine challenge test, a "direct" airway challenge test. Here, the task force provides an updated description of the pathophysiology and the methods to conduct indirect challenge tests. Because indirect challenge tests trigger airway narrowing through the activation of endogenous pathways that are involved in asthma, indirect challenge tests tend to be specific for asthma and reveal much about the biology of asthma, but may be less sensitive than direct tests for the detection of airway hyperresponsiveness. Read More

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http://erj.ersjournals.com/lookup/doi/10.1183/13993003.01033
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http://dx.doi.org/10.1183/13993003.01033-2018DOI Listing
November 2018
16 Reads

Sex-Dependent Effects of Environmental Enrichment on Spatial Memory and Brain-Derived Neurotrophic Factor (BDNF) Signaling in a Developmental "Two-Hit" Mouse Model Combining BDNF Haploinsufficiency and Chronic Glucocorticoid Stimulation.

Front Behav Neurosci 2018 9;12:227. Epub 2018 Oct 9.

Department of Psychiatry, School of Clinical Sciences, Monash Medical Centre, Monash University, Clayton, VIC, Australia.

Neurodevelopmental disorders are thought to be caused by a combination of adverse genetic and environmental insults. The "two-hit" hypothesis suggests that an early first "hit" primes the developing brain to be vulnerable to a second "hit" during adolescence which triggers behavioral dysfunction. We have previously modeled this scenario in mice and found that the combined effect of a genetic hapolinsuffuciency in the brain-derived neurotrophic factor (BDNF) gene (1st hit) and chronic corticosterone (CORT) treatment during adolescence (2nd hit), caused spatial memory impairments in adulthood. Read More

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https://www.frontiersin.org/article/10.3389/fnbeh.2018.00227
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http://dx.doi.org/10.3389/fnbeh.2018.00227DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6189322PMC
October 2018
7 Reads

The Wingate anaerobic test cannot be used for the evaluation of growth hormone secretion in children with short stature.

J Sport Health Sci 2017 Dec 24;6(4):443-446. Epub 2016 Jun 24.

Child Health and Sports Center, Pediatric Department, Meir Medical Center, Sackler School of Medicine, Tel Aviv University, Kfar-Saba 44281, Israel.

Purpose: To assess the growth hormone (GH) response to the Wingate anaerobic test (WAnT) among children with short stature and suspected GH deficiency. We hypothesized that the GH response to the WAnT would be similar to the GH response to a commonly used pharmacologic provocation test.

Methods: Ten children (6 males and 4 females, age range 9. Read More

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http://dx.doi.org/10.1016/j.jshs.2016.06.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6189253PMC
December 2017
2 Reads

Combined extracts of Garcinia mangostana fruit rind and Cinnamomum tamala leaf supplementation enhances muscle strength and endurance in resistance trained males.

J Int Soc Sports Nutr 2018 Oct 22;15(1):50. Epub 2018 Oct 22.

Laila Nutraceuticals R&D Center, 181/2, JRD Tata Industrial Estate, Kanur, Vijayawada, Andhra Pradesh, 520007, India.

Background: A proprietary composition GMCT contains extracts of two popular Asian herbs viz., Garcinia mangostana (GM) fruit rind and Cinnamomum tamala (CT) leaf. We systematically evaluated physical performance and muscle strength enhancing ability of GMCT in a preclinical mouse model followed by a 42-days double-blind placebo controlled human trial in resistance trained adult males. Read More

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https://jissn.biomedcentral.com/articles/10.1186/s12970-018-
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http://dx.doi.org/10.1186/s12970-018-0257-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6196563PMC
October 2018
11 Reads

Treadmill running suppresses the vulnerability of dopamine D2 receptor deficiency to obesity and metabolic complications: a pilot study.

J Exerc Nutrition Biochem 2018 Sep;22(3):42-50

Purpose: To investigate the effect of treadmill running on D2R deficiency related susceptibility to high fat diet (HFD )-induced obesity and its metabolic complications.

Methods: D2R-/- and +/- mice were obtained by backcrossing D2R+/- heterozygotes on wild type (WT) littermates (C57BL/6J background) for >10 generations. Mice were randomly assigned to 1) WT mice with standard chow (SC) (WT+SC); 2) WT mice with high-fat diet (WT+HFD); 3) WT mice with high-fat diet plus exercise (WT+HFD+EX), 4) heterozygous (HET) D2R mice with SC (HET+SC); 5) heterozygous D2R mice with HFD (HET+HFD); and 6) heterozygous D2R mice with HFD plus exercise (HET+HFD+EX). Read More

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http://dx.doi.org/10.20463/jenb.2018.0023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6199485PMC
September 2018
8 Reads

Nr5a1-Cre-mediated Tspo conditional knockout mice with low growth rate and prediabetes symptoms - A mouse model of stress diabetes.

Biochim Biophys Acta Mol Basis Dis 2019 Jan 18;1865(1):56-62. Epub 2018 Oct 18.

The Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada; Department of Medicine, McGill University, Montreal, Quebec, Canada; Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA, United States. Electronic address:

Translocator protein (TSPO) is a high-affinity cholesterol- and drug-binding mitochondrial protein. Nuclear receptor subfamily 5 group A member 1 or steroidogenic factor 1 (Nr5a1)-Cre mice were previously used to generate steroidogenic cell-specific Tspo gene conditional knockout (cKO) mice. TSPO-depleted homozygotes showed no response to adrenocorticotropic hormone (ACTH) in stimulating adrenal cortex corticosterone production but showed increased epinephrine synthesis in the medulla. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09254439183039
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http://dx.doi.org/10.1016/j.bbadis.2018.10.022DOI Listing
January 2019
9 Reads

The impact of expectancy on cognitive performance during alcohol hangover.

BMC Res Notes 2018 Oct 18;11(1):730. Epub 2018 Oct 18.

Division of Pharmacology, Utrecht University, Universiteitsweg 99, 3584 CG, Utrecht, The Netherlands.

Objective: Knowing the purpose of a clinical study may provoke expectancies among subjects that may influence the study outcome. For example, expectancies about a drug effect may cause subjects to put in more effort to counteract these effects on performance tasks, or cause stress or other mood alterations in anticipation of expected adverse effects. The objective of this study was to investigate to what extent expectancy effects will influence the magnitude of cognitive performance decrement in the alcohol hangover state. Read More

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https://bmcresnotes.biomedcentral.com/articles/10.1186/s1310
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http://dx.doi.org/10.1186/s13104-018-3827-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6193303PMC
October 2018
8 Reads