964,910 results match your criteria Pharmaceutical research[Journal]


Efficacy of novel β -adrenoreceptor agonist vibegron on nocturia in patients with overactive bladder: A post-hoc analysis of a randomized, double-blind, placebo-controlled phase 3 study.

Int J Urol 2018 Dec 17. Epub 2018 Dec 17.

Kyorin Pharmaceutical, Tokyo, Japan.

Objectives: To investigate the efficacy of vibegron on nocturia in patients with overactive bladder.

Methods: Among the Japanese overactive bladder patients enrolled in the placebo-controlled, multicenter, randomized, double-blind phase 3 study of vibegron, a total of 669 patients with nocturia (≥1 nocturnal void) were included. Changes from baseline in micturition parameters were compared for vibegron treatment (50 and 100 mg/day) versus placebo. Read More

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December 2018

Anthropometry, Physical and Movement Features, and Repeated-sprint Ability in Soccer Players.

Int J Sports Med 2018 Dec 17. Epub 2018 Dec 17.

Department of Biomedical and Neuromotor Science, University of Bologna, Bologna, Italy.

This study aimed to evaluate the associations of anthropometry, functional movement patterns (FMP) and physical performance characteristics with repeated-sprint ability (RSA) in male youth soccer players. Thirty six athletes (ages 16.6±0. Read More

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December 2018

Expression Profiles of microRNAs in Drug-Resistant Non-Small Cell Lung Cancer Cell Lines Using microRNA Sequencing.

Cell Physiol Biochem 2018 Dec 17;51(6):2509-2522. Epub 2018 Dec 17.

Department of Pharmacy, the First Affiliated Hospital of Zhengzhou University, Zhengzhou,

Background/aims: Drug resistance remains a main obstacle to the treatment of non- small cell lung cancer (NSCLC). The aim of this study was to identify the expression profiles of microRNAs (miRNAs) in drug-resistant NSCLC cell lines.

Methods: The expression profiles of miRNAs in drug-resistant NSCLC cell lines were examined using miRNA sequencing, and the common dysregulated miRNAs in these cell lines were identified and analyzed by bioinformatics methods. Read More

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December 2018

Apatinib inhibits tumor growth and angiogenesis in PNET models.

Endocr Connect 2018 Dec 1. Epub 2018 Dec 1.

Z Wang, Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, China.

Angiogenesis has a pivotal role in the growth and metastasis of pancreatic neuroendocrine tumors (PNETs). Apatinib inhibits angiogenesis as a highly selective VEGFR2 inhibitor and has been used to treat advanced gastric cancer and malignancies in clinical settings. However, the efficacy of apatinib in PNETs remains unclear. Read More

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December 2018

An insight into DNA binding properties of newly designed cationic δ,δ'‑diazacarbazoles: Spectroscopy, AFM imaging and living cells staining studies.

Spectrochim Acta A Mol Biomol Spectrosc 2018 Dec 10;211:260-271. Epub 2018 Dec 10.

CAS Key Laboratory of Special Pathogens and Biosafety, Center for Emerging Infectious Diseases, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei 430071, PR China. Electronic address:

Two cationic δ,δ'‑diazacarbazoles, 1‑Methyl‑5H‑pyrrolo[3,2‑b:4,5‑b']dipyridinium iodide (MPDPI) and 1,5‑Dimethyl‑5H‑pyrrolo[3,2‑b:4,5‑b']dipyridinium iodide (DPDPI), were devised and synthesized. Through characterizations of the interactions between DNA and the two δ,δ'‑diazacarbazoles by various spectroscopy means, the strong interactions between the two compounds and double-strand DNA have been observed and the interaction types and mechanisms were explored. UV-Vis and fluorescent data have shown the big changes of DNA in the presence of either of the two compounds, demonstrating that both of the δ,δ'‑diazacarbazoles can bind to DNA tightly, and high ionic strength decreased the intercalative interactions. Read More

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December 2018

Unravel a neuroactive sHA sulfation pattern with neurogenesis activity by a library of defined oligosaccharides.

Eur J Med Chem 2018 Dec 4;163:583-596. Epub 2018 Dec 4.

State Key Laboratory of Natural and Biomimetic Drugs, Department of Chemical Biology, School of Pharmaceutical Sciences, Peking University, No. 38 Xueyuan Road, 100191, Haidian District, Beijing, China. Electronic address:

Sulfated hyaluronic acid (sHA) is chemically synthetic mimetic of glycosaminoglycan (GAG) presenting promising biological functions. Specific sulfation pattern, termed as sulfation code plays critical roles in regulating the binding mode between GAG and proteins. As a structural analogue of chondroitin sulfate (CS), sHA bears much higher molecular weight and is nearly free of other proteoglycan contaminants. Read More

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December 2018

Competitive removal of Pb and malachite green from water by magnetic phosphate nanocomposites.

Water Res 2018 Nov 28;150:442-451. Epub 2018 Nov 28.

College of Chemistry and Pharmaceutical Sciences, Qingdao Agricultural University, Qingdao, 266109, China.

The competitive removal of Pb and malachite green (MG) from water by three magnetic phosphate nanocomposites (FeO/Ba(PO), FeO/Sr(PO)(OH), and FeO/SrBa(PO)(OH), namely "FBP", "FSP", and "FSBP", respectively) was systematically investigated compared with FeO ("F") nanoparticle. Temperature and adsorbent dosage for competitive removal were optimized to be 20 °C and 0.05 g in 50 mL. Read More

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November 2018

Identification of novel PI3Kδ inhibitors by docking, ADMET prediction and molecular dynamics simulations.

Comput Biol Chem 2018 Dec 7;78:190-204. Epub 2018 Dec 7.

Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics), School of Pharmacy, Tianjin Medical University, Tianjin 300070, China. Electronic address:

Background: Phosphoinositide-3-kinase Delta (PI3Kδ) plays a key role in B-cell signal transduction and inhibition of PI3Kδ is confirmed to have clinical benefit in certain types of activation of B-cell malignancies. Virtual screening techniques have been used to discover new molecules for developing novel PI3Kδ inhibitors with little side effects.

Method: Computer aided drug design method were used to rapidly screen optimal PI3Kδ inhibitors from the Asinex database. Read More

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December 2018

Identification of novel PPARα/γ dual agonists by pharmacophore screening, docking analysis, ADMET prediction and molecular dynamics simulations.

Comput Biol Chem 2018 Nov 27;78:178-189. Epub 2018 Nov 27.

Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics), School of Pharmacy, Tianjin Medical University, Tianjin, China. Electronic address:

PPARα and PPARγ play an important role in regulating glucose and lipid metabolism. The single and selective PPARα or PPARγ agonists have caused several side effects such as edema, weight gain and cardiac failure. In the recent years, the dual PPARs agonist development has become a hot topic in the antidiabetic medicinal chemistry field. Read More

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November 2018

Biosynthesized of reduced graphene oxide nanosheets and its loading with paclitaxel for their anti cancer effect for treatment of lung cancer.

J Photochem Photobiol B 2018 Nov 22;191:13-17. Epub 2018 Nov 22.

Department of pharmacy, Fujian Provincial Hospital& Fujian Medical University, People's Republic of China; Molecular Biology Laboratory of Chinese Traditional Medicine, Fujian Provincial Hospital, People's Republic of China. Electronic address:

Multifunctional nanocarriers are in immediate need to develop anticancer activity for the treatment of cancers. In the present research, the graphene oxide was reduced via an efficient method which reduced to RGO by using Euphorbia milii leaves extract. Thus obtained RGO nanocomposites were subsequently characterized by means UV-Vis absorption technique. Read More

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November 2018

Quality assessment of Astragali Radix from different production areas by simultaneous determination of thirteen major compounds using tandem UV/charged aerosol detector.

J Pharm Biomed Anal 2018 Dec 10;165:233-241. Epub 2018 Dec 10.

Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.

To identify more chemical markers for improving the quality standard and evaluate producing areas differentiation of Astragali Radix (AR), a simple, low-cost and reliable chromatography method based on a high performance liquid chromatography (HPLC) coupled with ultraviolet (UV) detector and charged aerosol detector (CAD) for separation of 13 major chemical components, including 8 flavonoids and 5 astragalosides in AR extract, was developed. The contents of 13 compounds in total of 27 herb samples, collected from different cultivating regions, were determined and compared. Moreover, chemometric analysis techniques with principal component constituent analysis (PCA) and cluster analysis (CA) were performed to discriminate the samples from different producing areas. Read More

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December 2018

Immediate Hypersensitivity to Polyethylene Glycols and Polysorbates: More Common Than We Have Recognized.

J Allergy Clin Immunol Pract 2018 Dec 14. Epub 2018 Dec 14.

Division of Infectious Diseases, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

Background: The most common immediate hypersensitivity to macrogols is associated with PEG 3350, however the epidemiology, mechanisms and cross-reactivity are poorly understood. Thousands of medications contain either PEGs or structurally similar polysorbates.

Objective: Our objective was to better understand the mechanism, cross-reactivity and scope of PEG hypersensitivity. Read More

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December 2018
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DOX Loaded Aggregation-induced Emission (AIE) Active Polymeric Nanoparticles as Fluorescence Resonance Energy Transfer (FRET) Traceable Drug Delivery System for Self-indicating Cancer Therapy.

Acta Biomater 2018 Dec 14. Epub 2018 Dec 14.

College of Pharmaceutical Science, Zhejiang University, 866 Yuhangtang Road, Hangzhou, 310058, PR China. Electronic address:

In this study, an AIE-active polymer (FTP) was successfully prepared and employed to load anti-cancer drug doxorubicin (DOX) for self-indicating cancer therapy via dual FRET process. Our results demonstrated that the FTP polymer could self-assemble into nanoparticles (NPs) in aqueous solutions to give strong fluorescence emission via intramolecular FRET process. The DOX loaded FTP NPs (drug loading content: 21. Read More

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December 2018

Status of antimicrobial stewardship programs in Nigerian tertiary healthcare facilities; findings and implications.

J Glob Antimicrob Resist 2018 Dec 14. Epub 2018 Dec 14.

Division of Clinical Pharmacology, Karolinska Institute, Stockholm, Sweden; Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, United Kingdom; Health Economics Centre, Liverpool University Management School, Chatham Street, Liverpool, UK. Electronic address:

Objectives: The problem of antimicrobial resistance (AMR) is increasing worldwide with health-related and economic consequences. This is a concern in Africa, including Nigeria the most populous country in Africa, with its high rates of infectious diseases. Approaches to reducing AMR include instigating antimicrobial stewardship programs (ASPs) in hospitals. Read More

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December 2018

Dissolvable microneedle patch containing doxorubicin and docetaxel is effective in 4T1 xenografted breast cancer mouse model.

Int J Pharm 2018 Dec 14. Epub 2018 Dec 14.

Department of Pharmacy, Birla Institute of Technology and Science (BITS) Pilani, Hyderabad Campus, Hyderabad 500078, Telangana, India. Electronic address:

Microneedle-devices provide a promising alternative to syringe-injection-based administration of chemotherapeutics. Dissolvable polymeric microneedles provide possibility of carrying greater payload and dual drugs. Here, we report development of polyvinyl pyrrolidone and polyvinyl alcohol composite dissolvable polymeric microneedle system for co-delivery of doxorubicin HCl and docetaxel. Read More

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December 2018
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RGD-modified PEGylated paclitaxel nanocrystals with enhanced stability and tumor-targeting capability.

Int J Pharm 2018 Dec 14. Epub 2018 Dec 14.

Department of Pharmaceutics, School of Pharmacy, Fudan University & Key Laboratory of Smart Drug Delivery (Fudan University), Ministry of Education, Shanghai 201203, China.

Nanocrystals has been constructed for insoluble drugs as a novel type of nanoscale drug delivery systems with high drug loading. How to prepare nanocrystals with good stability and tumor targeting capability is still challenging. This study was to modify paclitaxel nanocrystals with polyethylene glycol (PEG) for stabilization and RGD peptide for tumor targeting. Read More

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December 2018

In vitro Drug Release from Acetylated High Amylose Starch-Zein Films for Oral Colon-Specific Drug Delivery.

Int J Pharm 2018 Dec 14. Epub 2018 Dec 14.

School of Pharmacy, University of East Anglia, Norwich NR7 1AT, UK. Electronic address:

This study describes the preparation of free films of zein with and without acetylated high amylose maize starch (HAS) and their corresponding coated tablets as a novel approach to colonic drug delivery. We hypothesise that the embedding of a digestible starch component within the inert zein would allow the film to remain intact until the large intestine is reached. Free films of zein alone and starch/zein were prepared and characterised. Read More

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December 2018

The Acute Influence of Acid Suppression with Esomeprazole on Gastrointestinal Microbiota and Brain Gene Expression Profiles in a Murine Model of Restraint Stress.

Neuroscience 2018 Dec 14. Epub 2018 Dec 14.

Division of Infectious Diseases, University of Colorado Anschutz Medical Campus, B168 12700 E. 19th Avenue, Aurora, CO 80045, USA. Electronic address:

The central nervous system (CNS) and gastrointestinal tract (GIT) are linked through neuro-endocrine and humoral pathways. Critically ill patients suffer severe physical and emotional stress and frequently receive acid suppressants; however, stress and acid suppression may alter GIT microbiota. This study evaluated the effects of acid suppression on the GIT microbiota and genome-wide expression of brain-specific genes in a murine model of restraint stress. Read More

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December 2018

Quality-by-design approach as a systematic tool for the development of nanopharmaceutical products.

Drug Discov Today 2018 Dec 14. Epub 2018 Dec 14.

Department of Pharmaceutics, School of Pharmaceutical Education & Research, Jamia Hamdard, New Delhi-110062, India. Electronic address:

In recent decades, extensive emphasis has been given on developing nanopharmaceutical products for improving the therapeutic performance of drugs, resulting in an increasing number of product approvals by drug regulatory agencies. Although nanopharmaceuticals are subjected to the same regulatory pathways as conventional pharmaceutical products, their biopharmaceutical characteristics at the nanoscale make them vulnerable to high variability in quality. Positive effects on drug quality assurance have resulted from adopting systematic quality-by-design (QbD) principles, boosting pharmaceutical manufacturing with improvements in the quality, safety, and efficacy of drugs. Read More

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December 2018

Extracellular vesicles enhance the targeted delivery of immunogenic oncolytic adenovirus and paclitaxel in immunocompetent mice.

J Control Release 2018 Dec 14. Epub 2018 Dec 14.

Department of Oncology and Hemato-Oncology, Center of Excellence on Neurodegenerative Diseases, University of Milan, Milan, Italy. Electronic address:

Extracellular vesicles (EVs), are naturally occurring cargo delivery tools with the potential to be used as drug vehicles of single agents or combination therapies. We previously demonstrated that human lung cancer cell-derived EVs could be used for the systemic delivery of oncolytic virus (OVs) and chemotherapy drugs such as paclitaxel (PTX), leading to enhanced anti-tumor effects in nude mice. In the current work, we evaluated the biodistribution of EVs by using bioluminescence and fluorescence imaging technologies, thus proving the ability of these EVs-formulations to specifically target the neoplasia, while leaving other body tissues unaffected. Read More

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December 2018

Enhanced intranasal insulin delivery by formulations and tumor protein-derived protein transduction domain as an absorption enhancer.

J Control Release 2018 Dec 14. Epub 2018 Dec 14.

Department of Pharmaceutics and Biomedical Engineering, Purdue University, West Lafayette, IN 47907, USA.

One of the key factors for successful development of an intranasal insulin formulation is an absorption enhancer that would deliver insulin efficiently across nasal membranes without causing damage to mucosa or inducing protein aggregation under physiological conditions. In the present study, a protein transduction domain (PTD1) and its L-form with the double substitution A6L and I8A (PTD4), derived from human translationally controlled tumor protein, were used as absorption enhancers. PTD4 exhibited higher compatibility with insulin in terms of biophysical properties analyzed using μDSC, DLS, and CD. Read More

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December 2018

Thiol functionalization of flaxseed mucilage: Preparation, characterization and evaluation as mucoadhesive polymer.

Int J Biol Macromol 2018 Dec 14. Epub 2018 Dec 14.

Drug Delivery Research Laboratory, Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science and Technology, Hisar 125001, India. Electronic address:

The aim of present study is to browse mucoadhesive potential of flaxseed mucilage after thiol functionalization. Thiol-derivatization of flaxseed mucilage (FSM) polysaccharide was obtained by esterification with thioglycolic acid. Thiolation of FSM was confirmed by -SH stretch in FTIR spectra at 2549. Read More

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December 2018

Organic Anion Transporting Polypeptide 2B1 - More than a Glass-Full of Drug Interactions.

Pharmacol Ther 2018 Dec 14. Epub 2018 Dec 14.

University of Washington, School of Pharmacy, Department of Pharmaceutics, Seattle, WA, USA. Electronic address:

The importance of uptake transporters in determining drug disposition is increasingly appreciated. While the focus of regulatory agencies worldwide has been on the hepatic organic anion transporting polypeptides (OATPs) 1B1 and 1B3, there is another isoform of the OATP sub-family, OATP2B1, which should be considered equally relevant. Unlike the other members of the OATP sub-family, OATP2B1 is expressed in multiple organs in humans, including in the intestine and the liver. Read More

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December 2018
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A tale of two steroids: the importance of the androgens DHEA and DHEAS for early neurodevelopment.

J Steroid Biochem Mol Biol 2018 Dec 14. Epub 2018 Dec 14.

School of Health & Biomedical Sciences, RMIT University - Bundoora Campus, Melbourne, 3083, Australia. Electronic address:

DHEA and DHEAS are neuroactive neurosteroids that interact with several major receptor system in the brain, including sigma (σ), glutamate, and GABA-A receptors. It has been recognized as early as 1952, that the loss of DHEA/DHEAS in adult life is associated with neuropsychiatric disorders (eg schizophrenia, depression). However, the mechanistic role for DHEA/DHEAS in any of these domains remains speculative, not the least because the presence of these androgens in the adrenal gland and brain is largely confined to humans and only some non-human primates. Read More

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December 2018

Mechanisms of poor oral bioavailability of flavonoid Morin in rats: From physicochemical to biopharmaceutical evaluations.

Eur J Pharm Sci 2018 Dec 14. Epub 2018 Dec 14.

School of Pharmaceutical Sciences, Zhengzhou University, No.100. Kexue Road, Zhengzhou, Henan Province 450001, China; Key Laboratory of Targeting Therapy and Diagnosis for Critical Diseases, Zhengzhou 450001, China; Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province, China. Electronic address:

We recently reported that the absolute oral bioavailability of flavonoid Morin was extremely low at 0.45%, resulting in unsatisfied therapeutic efficacy in vivo. The present study was aimed to systemically assess the pre-absorption risks of Morin for rationale formulation design. Read More

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December 2018
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Bioluminescence imaging of Arc expression in mouse brain under acute and chronic exposure to pesticides.

Neurotoxicology 2018 Dec 14. Epub 2018 Dec 14.

Department of Molecular Neuroscience, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, 930-0194, Japan. Electronic address:

Exposure to pesticides can induce neurobehavioral effects in rodents, as well as in other mammals, including humans. However, the effects of the toxicity of pesticides on the central nervous system (CNS) remain largely unclear. The expression of the activity-regulated cytoskeleton-associated protein gene (Arc) is induced in a neuronal-activity-dependent manner and is implicated in synaptic and experience-dependent plasticity. Read More

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December 2018

Macromolecular crowding and membrane binding proteins: the case of phospholipase A.

Chem Phys Lipids 2018 Dec 14. Epub 2018 Dec 14.

Division of Chemistry, School of Pharmacy and Biological Sciences, University of Brighton, BN2 4GL, United Kingdom. Electronic address:

Cells contain high levels of macromolecular crowding; understanding how macromolecular crowding impacts the behaviour of biological systems can give new insights into biological phenomena and disease pathologies. In this study, we assess the effect of macromolecular crowding on the catalytic activity of the biomembrane binding protein phospholipase A (PLA). Using 3D-printed equilibrium dialysis chambers we show that macromolecular crowding increases the binding of PLA to lipid vesicles. Read More

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December 2018

Retrospective analysis of long-term gastrointestinal symptoms after Clostridium difficile infection in a nonelderly cohort.

PLoS One 2018 17;13(12):e0209152. Epub 2018 Dec 17.

Health Outcomes Unit, Department of Health Law, Policy and Management, Boston University School of Public Health, Boston, Massachusetts, United States of America.

Elderly patients and those with comorbid conditions are at high risk for poor outcomes after Clostridium difficile infection (CDI) but outcomes in a healthier, nonelderly population are not well described. We sought to investigate gastrointestinal diagnoses and CDI during hospitalizations in the 24 to 36 months after an initial episode of CDI in nonelderly patients in a cohort with an overall low prevalence of comorbid conditions. We performed a retrospective analysis of hospital admissions from 2010-2013 using the Truven MarketScan database of employment-based private insurance claims. Read More

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December 2018

Cholinesterase inhibitor rivastigmine enhances nerve growth factor-induced neurite outgrowth in PC12 cells via sigma-1 and sigma-2 receptors.

PLoS One 2018 17;13(12):e0209250. Epub 2018 Dec 17.

Department of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan.

Rivastigmine (Riv) is a potent and selective cholinesterase (acetylcholinesterase, AChE and butyrylcholinesterase, BuChE) inhibitor developed for the treatment of Alzheimer's disease (AD). To elucidate whether Riv causes neuronal differentiation, we examined its effect on nerve growth factor (NGF)-induced neurite outgrowth in PC12 cells. At concentrations of 0-100 μM, Riv was non-toxic in PC12 cells. Read More

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December 2018

Genome wide association study to identify predictors for severe skin toxicity in colorectal cancer patients treated with cetuximab.

PLoS One 2018 17;13(12):e0208080. Epub 2018 Dec 17.

Department of Clinical Oncology, Leiden University Medical Center, Leiden, The Netherlands.

EGFR-antibodies are associated with significant skin toxicity, including acneiform rash and folliculitis. It remains impossible to predict the occurrence of severe skin toxicity due to the lack of predictive markers. Here, we present the first genome-wide association study (GWAS) to find single nucleotide polymorphisms (SNPs) associated with EGFR inhibitor-induced skin toxicity using data of the multicentre randomized phase III CAIRO2 trial (clinicaltrials. Read More

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December 2018
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Genome-wide association study (GWAS) of ovarian cancer in Japanese predicted regulatory variants in 22q13.1.

PLoS One 2018 17;13(12):e0209096. Epub 2018 Dec 17.

Laboratory of Clinical Genome Sequencing, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan.

Genome-wide association studies (GWAS) have identified greater than 30 variants associated with ovarian cancer, but most of these variants were investigated in European populations. Here, we integrated GWAS and subsequent functional analyses to identify the genetic variants with potential regulatory effects. We conducted GWAS for ovarian cancer using 681 Japanese cases and 17,492 controls and found that rs137672 on 22q13. Read More

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December 2018
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Familial episodic limb pain in kindreds with novel Nav1.9 mutations.

PLoS One 2018 17;13(12):e0208516. Epub 2018 Dec 17.

Department of Health and Environmental Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

We previously performed genetic analysis in six unrelated families with infantile limb pain episodes, characterized by cold-induced deterioration and mitigation in adolescence, and reported two new mutations p.R222H/S in SCN11A responsible for these episodes. As no term described this syndrome (familial episodic pain: FEP) in Japanese, we named it as". Read More

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December 2018
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Role of CTRP3, CTRP9 and MCP-1 for the evaluation of T2DM associated coronary artery disease in Egyptian postmenopausal females.

PLoS One 2018 17;13(12):e0208038. Epub 2018 Dec 17.

Biochemistry Department, Faculty of Pharmacy, Ain Shams University, African Union Authority St. Abassia, Cairo, Egypt.

C1q complement/tumor necrosis factor (TNF)-related protein (CTRP) family comprises of 15 proteins that posses important implications in energy homeostasis, infection and inflammation. However, their roles in diabetes mellitus (DM) and its vascular complications have not been completely assessed. This works aims to study the association of two CTRPs; 3 and 9, with pro-inflammatory cytokine monocyte chemoattractant protein-1 (MCP-1), and biochemical parameters of type 2 diabetes (T2D), dyslipidemia and coronary artery disease (CAD). Read More

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December 2018

Improved growth of pea, lettuce, and radish plants using the slow release of hydrogen sulfide from GYY-4137.

PLoS One 2018 17;13(12):e0208732. Epub 2018 Dec 17.

Department of Chemistry, University of Iowa, Iowa City, Iowa, United States of America.

Hydrogen sulfide (H2S) is a key gasotransmitter in agriculture and has been reported to increase the growth of plants in the first two weeks and to mitigate the effects of environmental stressors. GYY-4137 is widely used in these studies because it slowly releases H2S, but there is disagreement as to whether it requires enzymes to release H2S. In this article we describe the release of H2S in water without enzymes and that it releases H2S faster in organic solvents than in water or when mixed in topsoil. Read More

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December 2018
2 Reads

Association and biomarker potential of elevated serum adiponectin with nephropathy among type 1 and type 2 diabetics: A meta-analysis.

PLoS One 2018 17;13(12):e0208905. Epub 2018 Dec 17.

Graduate School, University of Santo Tomas, Manila City, Philippines.

Background: Managing nephropathy associated with diabetes mellitus warrant investigation of relevant biomarkers in predicting this condition. Adiponectin (ADP) may hold promise as a biomarker for diabetic nephropathy (DN). In this study, we examine associations of ADP with DN by meta-analyzing relevant literature. Read More

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December 2018

A novel preservation solution containing a JNK inhibitory peptide efficiently improves islet yield for porcine islet isolation.

Transplantation 2018 Dec 13. Epub 2018 Dec 13.

Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan.

Background: For islet transplantation, pancreas preservation in UW solution is associated with disadvantages such as collagenase inhibition, resulting in poor islet yield and islets with poor viability. In this study, we evaluated a novel preservation solution, the extracellular-type c-Jun N-terminal kinase (JNK) inhibitor-containing (EJ) solution.

Methods: EJ solution has high sodium-low potassium composition with low viscosity compared to UW solution. Read More

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December 2018

Interprofessional Pharmacology Podcasting in Advanced Practice Nursing Seminar.

Nurse Educ 2018 Dec 13. Epub 2018 Dec 13.

Author Affiliations: Faculty (Dr Ro), Seattle University School of Nursing, Washington; Clinical Pharmacist (Dr Villarreal), University of Washington Medical Center Department of Pharmacy, Seattle.

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December 2018

Immature electrophysiological properties of human-induced pluripotent stem cell-derived neurons transplanted into the mouse cortex for 7 weeks.

Neuroreport 2018 Dec 15. Epub 2018 Dec 15.

Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo.

The transplantation of human-induced pluripotent stem cell (hiPSC)-derived cells has emerged as a potential clinical approach for the treatment of brain diseases. Recent studies with animal disease models have shown that hiPSC-derived neurons transplanted into the brain, especially the nigrostriatal area, could restore degenerated brain functions. Further works are required to test whether hiPSC-derived neurons can also gain functional properties for other cortical areas. Read More

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December 2018

Hyperglycemic ADR Distribution of Doxorubicin From VigiBase.

Am J Ther 2018 Dec 14. Epub 2018 Dec 14.

Department of Pharmacy, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

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December 2018

The pharmacokinetics, pharmacodynamics, and mucosal responses to maraviroc-containing PrEP Regimens in Men who have Sex with Men.

AIDS 2018 Dec 13. Epub 2018 Dec 13.

Division of Infectious Diseases, Weill Cornell Medicine, New York, New York.

Objective: HIV Prevention Trials Network 069/AIDS Clinical Trials Group A5305 was a study of 48-week oral pre-exposure prophylaxis (PrEP) regimens in MSM and transgender women. A rectal substudy was included to evaluate drug concentrations in rectal compartment vs. blood, gut-associated lymphoid tissue (GALT) responses to four antiretroviral PrEP regimens [maraviroc (MVC), MVC + emtricitabine (FTC), MVC + tenofovir (TFV) disoproxil fumarate, and TFV disoproxil fumarate + FTC], and to determine whether ARV exposure was associated with ex-vivo suppression of HIV infection in colorectal explants. Read More

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December 2018

From A to D: A Unique Case Report of Recovery after Longitudinal Myelitis Related to Lupus.

Am J Phys Med Rehabil 2018 Dec 14. Epub 2018 Dec 14.

HealthPartners Neuroscience Center, St. Paul, MN, USA.

Longitudinal myelitis secondary to an acute flare of systemic lupus erythematosus (SLE) has been reported in the literature. There have been few published cases of complete functional recovery in patients with systemic lupus erythematosus related longitudinal myelitis (SLE-LM). Of those cases, none have described in detail the rehabilitation course of treatment. Read More

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December 2018
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Preparation and in vitro / in vivo evaluation of 6-Gingerol TPGS/PEG-PCL polymeric micelles.

Pharm Dev Technol 2018 Dec 17:1-30. Epub 2018 Dec 17.

a Department of Pharmaceutics, School of Pharmacy, Center for Nano Drug/Gene Delivery and Tissue Engineering , Jiangsu University , Zhenjiang 212013 , People's Republic of China.

6-Gingerol, an active herbal ingredient of ginger, has various bioactivities such as anti-neurodegenerative disease, anti-inflammatory and so on. The aim of the present study was to enhance the oral bioavailability and brain distribution of 6-Gingerol via polymeric micelles. A polymeric micelles drug delivery system of 6-Gingerol consisting of D-α-Tocopheryl polyethylene glycol 1000 succinate (TPGS) and Poly (ethylene glycol)-poly (ε-caprolactone) (PEG-PCL) was prepared via solvent injection method. Read More

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December 2018

The effect of hospitalization on potentially inappropriate medication use in older adults with chronic kidney disease.

Curr Med Res Opin 2018 Dec 17:1-18. Epub 2018 Dec 17.

a Pharmacy, School of Medicine, College of Health and Medicine, University of Tasmania , Australia.

Objectives: Potentially inappropriate medications (PIMs) use is associated with increased morbidity and mortality in chronic kidney disease (CKD). However, there is paucity of data on how hospitalization affects PIMs use in older adults with CKD. Therefore, we aimed to measure the impact of hospitalization on PIMs use in older CKD patients, and identify factors predicting PIMs use. Read More

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December 2018

Development and evaluation of Chrysin-phospholipid complex loaded solid lipid nanoparticles - storage stability and in vitro anti-cancer activity.

J Microencapsul 2018 Dec 17:1-42. Epub 2018 Dec 17.

c Divisions of Metabolism and Pharmacokinetics , CSIR-Central Drug Research Institute , Lucknow , 226031 , Uttar Pradesh , India.

The aim of the present investigation was to prepare Chrysin-Phospholipid complex loaded solid lipid nanoparticles (Ch-PC-SLNs) for improving its encapsulation as compared to that of Chrysin loaded SLNs (Ch-SLNs) and evaluated for potential increase in the anti-cancer activity against MCF-7 cell line. The physiochemical characteristics and release kinetics for Ch-SLNs and Ch-PC-SLNs were evaluated and compared. Storage stability of Ch-PC-SLNs was evaluated up to 3 months. Read More

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December 2018
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New cytotoxic constituents in the water-soluble fraction from Momordicae Semen.

Nat Prod Res 2018 Dec 17:1-7. Epub 2018 Dec 17.

a School of Pharmacy , Shanghai Jiao Tong University , Shanghai , China.

Two new lignans mubezhisol (1) and mubezhisal (2), together with twenty six known compounds (3-28) were isolated from water-soluble fraction from the semens of Momordica cochinchinensis. In the subsequent action evaluation, four saponins (4, 6, 13, 27), six lignans (1, 2, 16, 17, 22, 23), and one naphthoquinone (24) exhibited the significant cytotoxicity. The results indicated that various saponins and lignans were mainly responsible for the antitumor activities of Momordicae Semen. Read More

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December 2018

Both β-1 adrenoceptors and AT1 receptors may not be involved in the catecholamine-induced lethal arrhythmias.

Can J Physiol Pharmacol 2018 Dec 17. Epub 2018 Dec 17.

Institute of Cardiovascular Sciences , St. Boniface General Hospital Research Centre , 351 Tache Avenue , Winnipeg, Manitoba, Canada , R2H 2A6 ;

Although an excessive amount of catecholamines is known to produce arrhythmias, the exact mechanisms of this derangement are not fully understood. For this purpose, Sprague-Dawley rats were treated with or without atenolol, a -adrenoceptor blocker (20 mg/kg/day), for 15 days followed by injections of epinephrine for cumulative doses of 4 to128 µg/kg. Another group of animals was pretreated with losartan, an angiotensin receptor (AT1) blocker (20 mg/kg/day) for comparison. Read More

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December 2018

Overcoming the emerging drug resistance of smoothened: an overview of small-molecule SMO antagonists with antiresistance activity.

Future Med Chem 2018 Dec 17. Epub 2018 Dec 17.

Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, 44, West Culture Road, Ji'nan 250012, PR China.

Hedgehog (HH) signaling pathway plays vital roles in controlling embryonic cell fate and homeostatic, and becomes dormant in mature individuals, aberrant activation of HH signaling pathway is involved in a number of human cancers. Smoothened (SMO), a vital transducer of HH signaling pathway, attracts significant attentions in HH signaling pathway-related cancer therapy. The approval of SMO antagonists Vismodegib proves that SMO is a promising therapeutic target, and a number of SMO antagonists are reported since then. Read More

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December 2018

HPTLC autography based screening and isolation of mushroom tyrosinase inhibitors of European plant species.

Chem Biodivers 2018 Dec 17. Epub 2018 Dec 17.

Institute of Pharmacy/Pharmacognosy, Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innrain 80-82, Innsbruck 6020, Austria, AUSTRIA.

In the course of this project 133 plants were evaluated on their ability to inhibit tyrosinase, a key enzyme in melanogenesis. The screening was performed by means of a HPTLC autographic assay resulting in the selection of three plants, Asplenium trichomanes, Pinus uncinata subsp. uncinata, and Scutellaria altissima, with promising tyrosinase inhibiting activities. Read More

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December 2018

Use of proton pump inhibitors among Danish children: a 16-year register-based nationwide study.

Basic Clin Pharmacol Toxicol 2018 Dec 17. Epub 2018 Dec 17.

Clinical Pharmacology and Pharmacy, Department of Public Health, University of Southern, Denmark.

Objectives: Proton pump inhibitors (PPI) are among the most frequently used drugs in the developed countries. In recent years, their use among children and adolescents has been on the increase. Guidelines recommend use for a period no longer than 4-8 weeks. Read More

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December 2018

Armeniaspirol antibiotic biosynthesis: Chlorination and oxidative dechlorination steps affording spiro[4.4]non-8-ene formation.

Chembiochem 2018 Dec 17. Epub 2018 Dec 17.

Helmholtz-Institute for Pharmaceutical Research Saarland, Microbial Natural Products, Campus Building C2.3, 66123, Saarbrücken, GERMANY.

Armeniaspirols are potent antibiotics containing an unusual spiro[4.4]non-8-ene moiety. We describe the cloning and functional analysis of the armeniaspirol biosynthetic gene cluster. Read More

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December 2018
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