1,887 results match your criteria Pharmaceutical Development and Technology [Journal]


Modern pediatric formulations of the soft candies in the form of a jelly: determination of metoclopramide content and dissolution.

Pharm Dev Technol 2019 Apr 24:1-22. Epub 2019 Apr 24.

a Laboratory of Pharmaceutical Analysis, Department of Pharmaceutical Technology , School of Pharmacy, Faculty of Health Sciences, Aristotle University of Thessaloniki , 54124 Thessaloniki , Greece.

In paediatrics, it is crucial to ameliorate the unpleasant taste of oral pharmaceutical formulations in order to facilitate patient compliance. Scientists' attempt to develop modern products for children is included among the new trends in pharmaceutical technology. Designing the preparation procedures and selecting the age-appropriate dosage form should be based on a benefit-risk approach, taking into account safety, efficacy, ease of use and accessibility to the patient. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/10837450.2019.1609499DOI Listing

Jet milling industrialization of sticky active pharmaceutical ingredient using quality by design approach.

Pharm Dev Technol 2019 Apr 18:1-55. Epub 2019 Apr 18.

b F.P.S. Food and Pharma Systems Srl , via Vandelli 20 - 22100 Como - Italy.

Jet milling is frequently used in pharmaceutical industry to achieve different objectives. It can be used as enabling technology to overcome poor water solubility linked to hydrophobic active of pharmaceutical ingredient (API) by reducing the particle size and therefore the dissolution rate. Alternatively jet milling can be used either to enhance blending efficiency of API with excipient in case of formulation at low dosage strength or to achieve the required particle size for inhalation therapy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/10837450.2019.1608449DOI Listing

Controlled release of dexamethasone from poly(vinyl alcohol) hydrogel.

Pharm Dev Technol 2019 Apr 1:1-29. Epub 2019 Apr 1.

a Drug Delivery Research Group , School of Science, Faculty of Health and Environmental Sciences, School of Science , Level 5, WZ building, 34 St Paul St , Auckland , 1010 , New Zealand.

This study investigated a chemically crosslinked poly (vinyl alcohol) (PVA) hydrogel controlled drug delivery system to deliver the anti-inflammatory drug dexamethasone (DEX). The PVA hydrogels, with different crosslinking densities, were characterised by swelling studies, electron scanning microscopy, viscosity, Fourier transform infrared spectroscopy (FTIR) and in vitro release assessment. Increasing crosslinking density slowed and decreased the swelling and water absorption. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/10837450.2019.1
Publisher Site
http://dx.doi.org/10.1080/10837450.2019.1602632DOI Listing
April 2019
3 Reads

Formulation of sustained release bioadhesive minitablets containing solid dispersion of levofloxacin for once daily ocular use.

Pharm Dev Technol 2019 Apr 1:1-48. Epub 2019 Apr 1.

a Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy , Cairo University , Cairo , Egypt.

This study aimed to increase ocular residence time of levofloxacin by formulation into zero order controlled release mucoadhesive minitablets for once daily administration using a hydrophobic-hydrophilic polymeric matrix. Levofloxacin was first formulated into solid dispersion with different ratios of Eudragit® RS then the resulting solid dispersion was mixed with different concentrations of Carbopol and other excipients to be finally compressed into minitablets. A 2^4 full factorial design was employed to estimate the effects and interactions of two formulation factors, and to establish their relationships with selected responses in the developed minitablets. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/10837450.2019.1602631DOI Listing
April 2019
1 Read

Self-assembled nanoparticles of reduction-sensitive poly (lactic-co-glycolic acid)-conjugated chondroitin sulfate A for doxorubicin delivery: preparation, characterization and evaluation.

Pharm Dev Technol 2019 Mar 25:1-29. Epub 2019 Mar 25.

a School of Pharmacy and Life Sciences, Jiujiang University , Jiujiang , 332000 , China.

In this study, reduction-sensitive self-assembled polymer nanoparticles based on poly (lactic-co-glycolic acid) (PLGA) and chondroitin sulfate A (CSA) were developed and characterized. PLGA was conjugated with CSA via a disulfide linkage (PLGA-ss-CSA). The critical micelle concentration (CMC) of PLGA-ss-CSA conjugate is 3. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/10837450.2019.1599914DOI Listing

Mechanics of Tablet Formation: A Comparative Evaluation of Percolation Theory with Classical Concepts.

Pharm Dev Technol 2019 Mar 25:1-52. Epub 2019 Mar 25.

a College of Pharmacy and Health Sciences, St. John's University , Queens , New York 11439 , USA.

The present study is based on the fundamentals of percolation theory and its application in understanding compression and compaction of powder materials. Four materials, i.e. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/10837450.2019.1599913DOI Listing

Evaluation of anti-inflammatory impact of dexamethasone-loaded PCL-PEG-PCL micelles on endotoxin-induced uveitis in rabbits.

Pharm Dev Technol 2019 Mar 20:1-9. Epub 2019 Mar 20.

a Drug Applied Research Center , Tabriz University of Medical Sciences , Tabriz , Iran.

The aim of this study was to investigate the capability of polycaprolactone-polyethylene glycol-polycaprolactone (PCL-PEG-PCL) micelles in improving the anti-inflammatory effects of dexamethasone (DEX). A film hydration method was used for the preparation of the DEX-loaded PCL-PEG-PCL micelles. In vitro cytotoxicity of the micelles obtained was investigated on L929 cells. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/10837450.2019.1
Publisher Site
http://dx.doi.org/10.1080/10837450.2019.1578370DOI Listing
March 2019
4 Reads

Cyproterone Acetate-Loaded Nanostructured Lipid Carriers: Effect of Particle Size on Skin Penetration and Follicular Targeting.

Pharm Dev Technol 2019 Mar 19:1-37. Epub 2019 Mar 19.

a Department of Pharmaceutics, Faculty of Pharmacy , Shiraz University of Medical Sciences , Shiraz , Iran.

Cyproterone acetate (CPA) is used to treat various skin disorders such as acne, hirsutism and alopecia. Due to the limited skin penetration of CPA, nanostructured lipid carriers (NLCs) with different size ranges were considered in this study in order to enhance skin penetration and to target hair follicles. Drug loading, drug release and morphological assessment were evaluated for each targeted size (100, 300 and 600 nm). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/10837450.2019.1596133DOI Listing
March 2019
18 Reads
1.335 Impact Factor

Preparation and Characterization of Co-processed Starch/MCC/Chitin Hydrophilic Polymers onto Magnesium Silicate.

Pharm Dev Technol 2019 Mar 19:1-50. Epub 2019 Mar 19.

b Jordanian Pharmaceutical Manufacturing Company , Amman , Jordan.

It was aimed to investigate the compressibility, compactibility, powder flow and tablet disintegration of a new excipient comprising magnesium (Mg) silicate co-processed (5% to 85% w/w) onto chitin, microcrystalline cellulose (MCC) and starch as the hydrophilic polymers of interest. Initially, the mechanism of tablet disintegration was studied by measuring water infiltration rate, moisture sorption, swelling capacity, and hydration ability. Moreover, the powders compression behavior was carried out by applying Kawakita model of compression analysis in addition to porosity and radial tensile strength measurements. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/10837450.2019.1596131DOI Listing

Revaprazan-loaded surface-modified solid dispersion: physicochemical characterization and in vivo evaluation.

Pharm Dev Technol 2019 Mar 18:1-6. Epub 2019 Mar 18.

a College of Pharmacy & Institute of Pharmaceutical Science and Technology, Hanyang University , Ansan , South Korea.

The purpose of this research was to develop a novel revaprazan-loaded surface-modified solid dispersion (SMSD) with improved drug solubility and oral bioavailability. The impact of carriers on aqueous solubility of revaprazan was investigated. HPMC and Cremophor A25 were selected as an appropriate polymer and surfactant, respectively, due to their high drug solubility. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/10837450.2019.1597114DOI Listing
March 2019
2 Reads

What to consider for a good quality PDE document?

Pharm Dev Technol 2019 Mar 13:1-32. Epub 2019 Mar 13.

d Lonza AG , Basel , Switzerland.

For the handling of active pharmaceutical ingredients (APIs) and production of medicinal products in shared facilities, the European Medicines Agency (EMA) has introduced the determination of permitted daily exposure (PDE) values to provide limits for cross-contamination. APIs have a desired pharmacological effect in the patient who intendedly uses a certain medicinal product. However, this effect is undesired in a patient that receives this API unintendedly as a cross-contamination of another medicinal product. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/10837450.2019.1592188DOI Listing

UV-Vis spectroscopic quantification of residual acetone during the development of nanoparticulate drug delivery systems.

Pharm Dev Technol 2019 Mar 7:1-10. Epub 2019 Mar 7.

a Instituto Politécnico Nacional , Centro de Investigación en Ciencia Aplicada y Tecnología Avanzada , Ciudad de Mexico , Mexico.

Methods for nanoparticles preparation often employ organic solvents in order to solubilize the non-polar constituents of the final nanostructures. In the research process, nanoparticles are assayed as aqueous suspensions in several cases, so that an excessive residual concentration of the organic solvent needs to be avoided since may lead to undesired secondary effects during biological tests. Despite the importance, residual solvent concentration is rarely determined, making necessary the development of quantification methods suitable for this purpose. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/10837450.2019.1592189DOI Listing

The need for new control strategies for particulate matter in parenterals.

Pharm Dev Technol 2019 Mar 1:1-12. Epub 2019 Mar 1.

d Institute of Solid State Physics, Graz University of Technology , Graz , Austria.

An undesirable characteristic in lyophilized parenteral products is the potential presence of particulate matter in the final product, which may affect patient safety. In this study, quality risk management tools described in the International Conference on Harmonization Guideline Q9 were used to estimate the risks for a pharmaceutical manufacturing line, based on three critical quality attributes: (1) visible particulate matter; (2) lyo-cake collapse traces; and (3) lyo-cake melt-back traces. Together with a Process Failure Mode Effect Analysis (PFMEA), an input-output analysis of the individual unit operations identified seven major material classes of extrinsic particulate matter. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/10837450.2019.1585449DOI Listing

Synergistic effect of polyethylene glycol and superdisintegrant on dissolution rate enhancement of simvastatin in pellet formulation.

Pharm Dev Technol 2019 Feb 19:1-9. Epub 2019 Feb 19.

b Department of Pharmaceutics , School of Pharmacy, Mashhad University of Medical Sciences , Mashhad , Iran.

Slow dissolution is a major drawback for poorly water-soluble drugs when they are extruded-spheronized with microcrystalline cellulose (MCC). Therefore, the aim of the current study was to explore excipients to enhance the dissolution of simvastatin without compromising the extrudability and sphericity of pellets. Pellets containing simvastatin, MCC and polyethylene glycols (PEGs) or superdisintegrants were prepared by extrusion-spheronization and their micromeritics and mechanical properties, drug release and solid state of simvastatin were studied. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/10837450.2019.1584632DOI Listing
February 2019

Transdermal fennel essential oil nanoemulsions with promising hepatic dysfunction healing effect: In vitro and in vivo study.

Pharm Dev Technol 2019 Feb 18:1-33. Epub 2019 Feb 18.

c Department of Chemistry of Natural and Microbial Products , National Research Centre , Dokki , Cairo 12622 , Egypt .

Fennel (Foeniculum vulgare Mill.) is a member of family Apiaceae. Trans-anethole, the major component of Fennel essential oil (FEO), possesses antioxidant and hepatoprotective effects. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/10837450.2019.1584633DOI Listing
February 2019
1 Read

Multiple linear regression applied to predicting droplet size of complex perfluorocarbon nanoemulsions for biomedical applications.

Pharm Dev Technol 2019 Mar 1:1-11. Epub 2019 Mar 1.

a Graduate School of Pharmaceutical Sciences , Duquesne University , Pittsburgh , PA , USA.

Multiple linear regression (MLR) modeling as a novel methodological advancement for design, development, and optimization of perfluorocarbon nanoemulsions (PFC NEs) is presented. The goal of the presented work is to develop MLR methods applicable to design, development, and optimization of PFC NEs in broad range of biomedical uses. Depending on the intended use of PFC NEs as either therapeutics or diagnostics, NE composition differs in respect to specific applications (e. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/10837450.2019.1578372DOI Listing
March 2019
2 Reads

Application of a quality-by-design approach for utilizing sodium stearyl fumarate as a taste-masking agent in dextromethorphan hydrobromide orally disintegrating tablets.

Pharm Dev Technol 2019 Feb 4:1-9. Epub 2019 Feb 4.

a Department of Pharmaceutics , College of Pharmacy, King Saud University , Riyadh , Kingdom of Saudi Arabia.

Orally dissolving tablets (ODTs) represent one of the recent advances in drug delivery. The foremost objective of this study was to optimize the utilization of lubricant sodium stearyl fumarate in the preparation of dextromethorphan hydrobromide ODTs with enhanced taste-masking properties. The simple blending of sodium stearyl fumarate with the powder bed would result in taste-masking through physical adsorption of the lubricant particles on the drug particles. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/10837450.2019.1
Publisher Site
http://dx.doi.org/10.1080/10837450.2019.1579228DOI Listing
February 2019
18 Reads

Evaluation of Topical Econazole Nitrate Formulations with Potential for Treating Raynaud's Phenomenon.

Pharm Dev Technol 2019 Feb 4:1-36. Epub 2019 Feb 4.

b Department of Medicine, Division of Rheumatology , University of Toledo , Toledo , USA.

Asbtract The purpose of this work was to design and characterize a topical formulation of econazole nitrate (EN) with potential for treating Raynaud's phenomenon (RP). Four topical dosage forms (F1_topical solution, F2_HPMC or hydroxypropyl methylcellulose dispersion, F3_ VersaBase cream and F4Lipoderm Activemax™ Cream) containing 3% w/w EN were prepared and characterized for drug content, pH, viscosity, spreadability, drug crystallinity, stability and in vitro permeation using Franz cells across pig ear skin, and results were compared to the 1% marketed EN cream. All four formulations had acceptable physical and visual characteristics required for topical application, with 3% w/w EN. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/10837450.2019.1578371DOI Listing
February 2019
3 Reads

Hyaluronic acid gel-core liposomes (hyaluosomes) enhance skin permeation of ketoprofen.

Pharm Dev Technol 2019 Jan 24:1-25. Epub 2019 Jan 24.

b Pharmaceutics Department, Faculty of Pharmacy , Minia University , Minia , Egypt.

Since FDA approval of the first transdermal patch in 1979, the utilizing of skin as a route of systemic drug administration has attracted the attention of the formulation scientists. The liposomes research in the area of transdermal drug delivery has been around for decades. This study aimed at comparing the latest gel-core liposomes (hyaluosomes) with non-conventional liposomal systems such as propylene glycol (PG)-liposomes, ethosomes, transferosomes and conventional liposomes loaded with ketoprofen. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/10837450.2019.1572761DOI Listing
January 2019
1 Read

Pegylated magnetic mesoporous silica nanoparticles decorated with AS1411 Aptamer as a targeting delivery system for cytotoxic agents.

Pharm Dev Technol 2019 Jan 18:1-36. Epub 2019 Jan 18.

a Nanotechnology Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences , Tehran , Iran.

Fulfilling the purpose of developing a NP with theragnostic capabilities, the current study describes synthesis of an aptamer-functionalized PEG-coated SPION/mesoporous silica core-shell nanoparticle for concurrent cancer targeted therapy and magnetic resonance imaging. SPIONs were synthesized according to a thermal decomposition method and served as cores for SPION/mesoporous silica core/shell nanoparticles (MMSNs). Doxorubicin was then successfully loaded in MMSNs which were then coated with di-carboxylic acid functionalized poly ethylene glycol (PEG-MMSNs). Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/10837450.2019.1
Publisher Site
http://dx.doi.org/10.1080/10837450.2019.1569678DOI Listing
January 2019
18 Reads
1.335 Impact Factor

Study of biodistribution and systemic toxicity of glucose functionalized SPIO/DOX micelles.

Pharm Dev Technol 2019 Jan 17:1-35. Epub 2019 Jan 17.

a Department of Biomedical Engineering, Faculty of Engineering , Mahidol University , Puttamonthon , Nakorn Pathom 73170 , Thailand.

The present study examined the cytotoxicity and magnetic resonance imaging (MRI) distribution of cancer-targeted, MRI-visible polymeric micelles that encapsulate doxorubicin (DOX) and superparamagnetic iron oxide (SPIO) and are conjugated with glucose as a targeting ligand. In this study, the micelles were characterized by dynamic light scattering to determine particle size and zeta potential. Morphology and structure of the micelles were evaluated by transmission electron microscopy. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/10837450.2019.1
Publisher Site
http://dx.doi.org/10.1080/10837450.2019.1569679DOI Listing
January 2019
17 Reads

Elucidating Spray Dried Dispersion Dissolution Mechanisms with Focused Beam Reflectance Measurement: Contribution of Polymer Chemistry and Particle Properties to Performance.

Pharm Dev Technol 2019 Jan 14:1-25. Epub 2019 Jan 14.

d Bristol-Myers Squibb, Drug Product Science and Technology , Reeds Lane, Moreton , liverpool , CH46 1QW United Kingdom of Great Britain and Northern Ireland.

Amorphous spray dried dispersions (SDDs) are a key enabling technology for oral solid dosage formulations, used to improve dissolution behaviour and clinical exposure of poorly-soluble active pharmaceutical ingredients (APIs). Appropriate assessment of amorphous dissolution mechanisms is an ongoing challenge. Here we outline the novel application using Focused Beam Reflectance Measurement (FBRM) to analyse particle populations orthogonal to USP 2 dissolution. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/10837450.2018.1559189DOI Listing
January 2019
2 Reads

Comparison of Cationic Liposome and PAMAM Dendrimer for Delivery of Anti-Plk1 siRNA in Breast Cancer Treatment.

Pharm Dev Technol 2019 Jan 11:1-27. Epub 2019 Jan 11.

a Department of Pharmaceutics , National Institute of Pharmaceutical Education and Research (NIPER) , Hyderabad 500037 , India.

Delivery of negatively charged, high molecular weight and unstable siRNA is difficult. The present study describes the development and comparison of cationic liposomes (CLs) and polyamidoamine (PAMAM) dendrimer generation 4 (PG4) nanocarriers of gene for cancer therapy. CLs and PG4 were complexed with anticancer siRNA (siPlk1) to form siPlk1-CLs lipoplex and siPlk1-PG4 dendriplex. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/10837450.2019.1
Publisher Site
http://dx.doi.org/10.1080/10837450.2019.1567763DOI Listing
January 2019
11 Reads

Characterization and pharmacokinetic evaluation of microcomposite particles of alpha lipoic acid/hydrogenated colza oil obtained in supercritical carbon dioxide.

Pharm Dev Technol 2019 Jan 11:1-29. Epub 2019 Jan 11.

j Department of Applied Chemistry, Faculty of Engineering , Oita University , 700 Dannoharu Oita-shi , 870-1192 , Japan.

The work reported here is an extension of our previous findings in which supercritical composite particles (SCP) of alpha lipoic acid (ALA) masked with hydrogenated colza oil (HCO) named as ALA/HCO/SCP were obtained by the modified particles from gas-saturated solutions (PGSS) process in supercritical carbon dioxide in order to obscure the unpleasant taste and odor of ALA. The masking effect on ALA/HCO/SCP was compared with the widely used mechano-chemiclally masked formulation of ALA and HCO named as MC-50F. In the present study, ALA/HCO/SCP particles were found to have a significant improvement in regard to bitterness, numbness, and smell compared to ALA bulk powders suggesting they were well coated. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/10837450.2019.1567760DOI Listing
January 2019
5 Reads

Spray-Dried Alginate Microparticles for Potential Intranasal Delivery of Ropinirole Hydrochloride: Development, Characterization and Histopathological Evaluation.

Pharm Dev Technol 2019 Jan 10:1-36. Epub 2019 Jan 10.

f School of Mathematics and Physics, College of Science, University of Lincoln , UK.

Ropinirole hydrochloride (RH) is an anti-Parkinson drug with relativity low oral bioavailability owing to its extensive hepatic first pass metabolism. Spray-dried mucoadhesive alginate microspheres of RH were developed and characterized followed by histopathological evaluation using nasal tissue isolated from sheep. Spherical microparticles having high product yield (around 70%) were obtained when the inlet temperature of spray drying was 140 °C. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/10837450.2019.1
Publisher Site
http://dx.doi.org/10.1080/10837450.2019.1567762DOI Listing
January 2019
2 Reads

Preparation and Characterization of Angiopep-2 Functionalized Ginsenoside-Rg3 Loaded Nanoparticles and the Effect on C6 Glioma Cells.

Pharm Dev Technol 2019 Jan 2:1-37. Epub 2019 Jan 2.

c Department of Pharmacy , Hebei North University , Zhangjiakou , China .

The purpose of this work was to prepare and characterize Angiopep-2 functionalized ginsenoside-Rg3 loaded nanoparticles (ANG-Rg3-NP) and evaluate the therapeutic effect on C6 glioma cells. Nanoparticles were prepared by the emulsion solvent evaporation method. Angiopep-2 was functionalized to nanoparticles via a maleimide-thiol covalent binding reaction to obtain ANG-Rg3-NP. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/10837450.2018.1551901DOI Listing
January 2019
3 Reads

Preparation and in vitro / in vivo evaluation of 6-Gingerol TPGS/PEG-PCL polymeric micelles.

Pharm Dev Technol 2018 Dec 17:1-30. Epub 2018 Dec 17.

a Department of Pharmaceutics, School of Pharmacy, Center for Nano Drug/Gene Delivery and Tissue Engineering , Jiangsu University , Zhenjiang 212013 , People's Republic of China.

6-Gingerol, an active herbal ingredient of ginger, has various bioactivities such as anti-neurodegenerative disease, anti-inflammatory and so on. The aim of the present study was to enhance the oral bioavailability and brain distribution of 6-Gingerol via polymeric micelles. A polymeric micelles drug delivery system of 6-Gingerol consisting of D-α-Tocopheryl polyethylene glycol 1000 succinate (TPGS) and Poly (ethylene glycol)-poly (ε-caprolactone) (PEG-PCL) was prepared via solvent injection method. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/10837450.2018.1558239DOI Listing
December 2018
2 Reads
1.335 Impact Factor

Controlling the internal morphology of aqueous core-PLGA shell microcapsules: promoting the internal phase separation via alcohol addition.

Pharm Dev Technol 2018 Dec 17:1-9. Epub 2018 Dec 17.

a School of Pharmacy , The University of Jordan , Amman , Jordan.

The ability to control the internal core architecture of polymeric microcapsules has a direct impact on their applications. However, this task, especially to produce microcapsules with a high percentage of mononuclear aqueous cores, proved to be challenging. In this work, and in continuation to our previous studies, we report a facile protocol to prepare poly(D,L-lactide-co-glycolide) (PLGA) microcapsules with unprecedented percentage (almost 100%) of mononuclear aqueous cores by the internal phase separation method via adding alcohols. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/10837450.2018.1
Publisher Site
http://dx.doi.org/10.1080/10837450.2018.1558238DOI Listing
December 2018
12 Reads

Effects of silymarin-loaded amphiphilic chitosan polymeric micelles on the renal toxicity and anticancer activity of cisplatin.

Pharm Dev Technol 2018 Dec 7:1-27. Epub 2018 Dec 7.

a Department of Pharmaceutical Technology, Faculty of Pharmacy , Silpakorn University , Nakhon Pathom , 73000 , Thailand.

This research aimed to evaluate the effects of silymarin (SM)-loaded polymeric micelles (PMs) on the renal toxicity and anticancer activity of cisplatin. Amphiphilic chitosan derivatives were employed to develop SM-loaded PMs. The permeation across an intestinal membrane, cytotoxicity, and renal toxicity of cisplatin during the treatment were evaluated. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/10837450.2018.1556690DOI Listing
December 2018
10 Reads
1.335 Impact Factor

In vivo study of mPEG-PCL as a nanocarriers for anti-inflammatory drug delivery of simvastatin.

Pharm Dev Technol 2018 Dec 5:1-8. Epub 2018 Dec 5.

e Cancer Gene Therapy Research Center , Zanjan University of Medical Sciences , Zanjan , Iran.

Purpose: In this study, methoxy poly (ethylene glycol)-poly (ε-caprolactone) (mPEG-PCL) di-block copolymers were synthesized. The purpose of this work is to investigate the in vivo anti-inflammatory effects of simvastatin-loaded micelles.

Methods: The structure of synthesized copolymers was characterized by using HNMR, FTIR, and GPC techniques. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/10837450.2018.1556689DOI Listing
December 2018
4 Reads

Optimization of nimesulide-loaded solid lipid nanoparticles (SLN) by factorial design, release profile and cytotoxicity in human Colon adenocarcinoma cell line.

Pharm Dev Technol 2019 Jun 4;24(5):616-622. Epub 2019 Jan 4.

a Department of Pharmaceutical Technology, Faculty of Pharmacy , University of Coimbra (FFUC), Pólo das Ciências da Saúde, Azinhaga de Santa Comba , Coimbra , Portugal.

The aim of this work is development of a nontoxic, long-term stable solid lipid nanoparticles (SLN) formulation for the loading of Nimesulide (NiM) by a 2 factorial design. The optimized formulation was composed of 10 wt% of glyceryl behenate and 2.5 wt% of poloxamer 188. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/10837450.2018.1
Publisher Site
http://dx.doi.org/10.1080/10837450.2018.1549075DOI Listing
June 2019
7 Reads

Pre-formulation investigations for establishing a protocol for treosulfan handling and activation.

Pharm Dev Technol 2019 Jun 10;24(5):639-648. Epub 2019 Jan 10.

d Department of Oncology and Pathology , Karolinska Institutet , Stockholm , Sweden.

Introduction: Treosulfan is an alkylating agent that is used for the treatment of ovarian cancer and for conditioning prior to stem cell transplantation. It is a prodrug that is activated non-enzymatically to two active epoxides.

Objectives: To optimize a protocol for both in vivo samples handling and in vitro drug preparation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/10837450.2018.1551903DOI Listing
June 2019
3 Reads
1.335 Impact Factor

Effects of formulation development methods on the stability of model protein pharmaceuticals embedded in solid lipid matrices.

Pharm Dev Technol 2019 Jun 27;24(5):649-662. Epub 2019 Jan 27.

b School of Pharmacy , University of Otago , Dunedin , New Zealand.

This study was conducted to investigate the influence of formulation development methods on the stability (secondary structure, aggregation, and biological activity) of protein drugs embedded in lipid matrices. Catalase, horseradish peroxidase, and α-chymotrypsin were employed as model proteins, while Precirol® AT05 (glyceryl palmitostearate) was used as lipid matrix. Protein-loaded lipid matrices were prepared using melting and mixing and wet granulation methods. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/10837450.2018.1551902DOI Listing
June 2019
1 Read

Brinzolamide-loaded nanoemulsions: ex vivo transcorneal permeation, cell viability and ocular irritation tests.

Pharm Dev Technol 2019 Jun 15;24(5):600-606. Epub 2019 Jan 15.

d Buchanan Ocular Therapeutics Unit, Department of Ophthalmology, New Zealand National Eye Centre, Faculty of Medical and Health Sciences , University of Auckland , Auckland , New Zealand.

The aim of this study was to investigate the corneal penetration of brinzolamide (BZ) nanoemulsions (NEs) and evaluate their in vitro and ex vivo irritancy potential. Twelve BZ NEs were prepared by the spontaneous emulsification method and ex vivo permeability studies were conducted using excised bovine corneas fixed onto Franz diffusion cells. To confirm the safety of the formulations for ophthalmic use, preparations were examined for potential ocular irritancy using a cell viability assay on retinal cells, the Hen's Egg Test-Chorio-Allantoic Membrane (HET-CAM) and the bovine corneal opacity-permeability (BCOP) test. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/10837450.2018.1
Publisher Site
http://dx.doi.org/10.1080/10837450.2018.1547748DOI Listing
June 2019
7 Reads

Clarithromycin laurate salt: physicochemical properties and pharmacokinetics after oral administration in humans.

Pharm Dev Technol 2019 Jun 7;24(5):607-615. Epub 2018 Dec 7.

g Al Taqaddom Pharmaceuticals , Amman , Jordan.

Objective: To prepare and characterize the physicochemical and pharmacokinetic properties of clarithromycin laurate (CLM-L), a fatty acid salt of clarithromycin (CLM).

Methods: CLM-L was prepared by a simple co-melting process. The formation of CLM-L was confirmed using FTIR, H NMR, and C NMR. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/10837450.2018.1
Publisher Site
http://dx.doi.org/10.1080/10837450.2018.1547749DOI Listing
June 2019
17 Reads
1.335 Impact Factor

Increased in vitro leishmanicidal activity of octyl gallate loaded poly(methyl methacrylate) nanoparticles.

Pharm Dev Technol 2019 Jun;24(5):593-599

a Department of Chemical Engineering and Food Engineering , Federal University of Santa Catarina , Florianópolis , Brazil.

The current paucity of effective and affordable drugs for the treatment of leishmaniasis renders the search for new therapeutic alternatives a priority. Gallic acid-related compounds display anti-parasitic activities and their incorporation into drug carrier systems, such as polymeric nanoparticles may be a viable alternative for leishmaniasis treatment. Therefore, this study focused on the synthesis and characterization of octyl gallate (G8) loaded poly(methyl methacrylate) (PMMA) nanoparticles via miniemulsion polymerization in order to increase the leishmanicidal activity of this compound. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/10837450.2018.1547747DOI Listing
June 2019
18 Reads

Silk fibroin nanoparticles for enhanced bio-macromolecule delivery to the retina.

Pharm Dev Technol 2019 Jun 19;24(5):575-583. Epub 2019 Mar 19.

a School of Pharmaceutical Sciences , Sun Yat-Sen University , Guangzhou , China.

The aim of this study was to investigate intravitreal injection of silk fibroin nanoparticles (SFNs) encapsulating bio-macromolecules, achieving enhanced drug bioavailability, and extended retention in retina. SFNs were prepared with regenerated silk fibroin using desolvation method with fluorescein isothiocyanate labeled bovine serum albumin (FITC-BSA) as bio-macromolecular model drug encapsulated. In vitro physicochemical properties and in vitro drug release of FITC-BSA loaded SFNs (FITC-BSA-SFNs) were evaluated. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/10837450.2018.1
Publisher Site
http://dx.doi.org/10.1080/10837450.2018.1545236DOI Listing
June 2019
12 Reads

Influence of protamine shell on nanoemulsions as a carrier for cyclosporine-A skin delivery.

Pharm Dev Technol 2019 Jun 7;24(5):630-638. Epub 2018 Dec 7.

a Departamento de Farmacia, Facultad de Química , Pontificia Universidad Católica de Chile , Santiago , Chile.

Novel protamine-based nanosystems have been studied for cyclosporine-A (CsA) skin delivery. Core-shell structure systems have been developed to this end. These vehicles have particles sizes of 200-300 nm, a low polydispersity index and a zeta potential which varies between -16 mV and +35 mV. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/10837450.2018.1550789DOI Listing
June 2019
1 Read

In-vivo anti-tumor activity of a novel poloxamer-based thermosensitive in situ gel for sustained delivery of norcantharidin.

Pharm Dev Technol 2019 Jun 9;24(5):623-629. Epub 2018 Dec 9.

c Department of Pharmacy , Zhejiang Cancer Hospital , Hangzhou , Zhejiang , PR China.

In order to develop a novel norcantharidin (NCTD) delivery system with slow drug release and specific targeting characteristics, we have developed a Poloxamer-based NCTD thermosensitive in situ gel. The evaluation of the characteristics of this system using both in vitro and in vivo methods was previously reported. However, its anti-tumor activity in vivo is still not confirmed. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/10837450.2018.1
Publisher Site
http://dx.doi.org/10.1080/10837450.2018.1550788DOI Listing
June 2019
5 Reads

Optimization of a dry powder inhaler of ciprofloxacin-loaded polymeric nanomicelles by spray drying process.

Pharm Dev Technol 2019 Jun;24(5):584-592

a Department of Pharmaceutics, School of Pharmacy , Shahid Beheshti University of Medical Sciences , Tehran , Iran.

Ciprofloxacin is a commonly prescribed antibiotic for treatment of pulmonary infections. Nanocarriers such as nanomicelles can increase the drug residence time in the lungs and enhance their antibacterial effects. Dry powder inhalers (DPIs) are the preferred pulmonary drug delivery system and preparation of an optimum nanoaggregate from nanomicelles by means of spray drying would be valuable. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/10837450.2018.1
Publisher Site
http://dx.doi.org/10.1080/10837450.2018.1545237DOI Listing
June 2019
15 Reads

Preparation and in vivo pharmacokinetics of rhGH-loaded PLGA microspheres.

Pharm Dev Technol 2019 Apr 13;24(4):395-401. Epub 2018 Nov 13.

b School of Pharmaceutical Sciences , Peking University , Beijing , China.

Recombinant human growth hormone (rhGH) therapy must be administered as a daily injection due to its short half-life. To achieve sustained release of rhGH, the preparation of rhGH-loaded PLGA microspheres was investigated, and the influence of various factors on encapsulation efficiency was tested, including rhGH concentration, the ratio of internal phase to organic phase, stirring speed, PVA concentration, surrounding pH value, and the type of emulsifier and organic solvent. A pharmacokinetic study was performed by subcutaneous administration to explore the sustained release effect. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/10837450.2018.1
Publisher Site
http://dx.doi.org/10.1080/10837450.2018.1502316DOI Listing
April 2019
5 Reads

On the plasticizing properties of divalproex sodium: physicochemical and spectroscopic characterization studies.

Pharm Dev Technol 2019 Apr 6;24(4):455-464. Epub 2018 Nov 6.

b Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers , The State University of New Jersey , Piscataway , NJ , USA.

The objective of the research was to demonstrate the plasticization properties of divalproex sodium, due to its component-valproic acid, on ethyl cellulose, which could prove beneficial for film fabrications or hot melt extrusion based formulations. Films containing 10-50% w/w (DVS/EC) as dry weight were prepared using solvent evaporation method and characterized using texture analyzer, hybrid rheometer, differential scanning calorimetry, thermogravimetry, X-ray diffractometry, polarized microscopy, FTIR, and Raman spectroscopy. It was found that there was a decrease in average peak load, melt viscosity, and glass transition temperature (T) while increase in elongation, with increase in concentration of DVS in the films. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/10837450.2018.1
Publisher Site
http://dx.doi.org/10.1080/10837450.2018.1514049DOI Listing
April 2019
11 Reads

Controlled release drug delivery systems.

Authors:
Paul W S Heng

Pharm Dev Technol 2018 11;23(9):833

a GEA-NUS Pharmaceutical Processing Research Laboratory, Department of Pharmacy , National University of Singapore.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/10837450.2018.1534376DOI Listing
November 2018
1 Read

Physiological Parameters of the Gastrointestinal Fluid Impact the Dissolution Behavior of the BCS Class IIa Drug Valsartan.

Authors:
Rania Hamed

Pharm Dev Technol 2018 Oct 15:1-31. Epub 2018 Oct 15.

a Department of Pharmacy, Faculty of Pharmacy , Al-Zaytoonah University of Jordan , Amman , Jordan.

The objective of this study was to investigate the effect of the physiological parameters (pH, buffer capacity, and ionic strength) of the gastrointestinal (GI) fluid on the dissolution behavior of the class II weakly acidic (BCS class IIa) drug valsartan. A series of in vitro dissolution studies was carried out on Diovan® immediate release tablets using media that cover the physiological range of pH (1.2 - 7. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/10837450.2018.1
Publisher Site
http://dx.doi.org/10.1080/10837450.2018.1536996DOI Listing
October 2018
18 Reads

Manufacturing classification system in the real world: factors influencing manufacturing process choices for filed commercial oral solid dosage formulations, case studies from industry and considerations for continuous processing.

Pharm Dev Technol 2018 Dec 13;23(10):964-977. Epub 2018 Nov 13.

i Curso de Farmácia, Centro de Ciências Biológicas e da Saúde , Universidade de Caxias do Sul , Caxias do Sul , Brazil.

Following the first Manufacturing Classification System (MCS) paper, the team conducted surveys to establish which active pharmaceutical ingredient (API) properties were important when selecting or modifying materials to enable an efficient and robust pharmaceutical manufacturing process. The most commonly identified factors were (1) API particle size: small particle sizes are known to increase risk of processing issues; (2) Drug loading in the formulation: high drug loadings allow less opportunity to mitigate poor API properties through the use of excipients. The next step was to establish linkages with process decisions by identifying publicly-available proxies for these important parameters: dose (in place of drug loading) and BCS class (in place of particle size). Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/10837450.2018.1
Publisher Site
http://dx.doi.org/10.1080/10837450.2018.1534863DOI Listing
December 2018
14 Reads
1.340 Impact Factor

Preparation, characterization, and evaluation of amino acid modified magnetic nanoparticles: drug delivery and MRI contrast agent applications.

Pharm Dev Technol 2018 Nov 9:1-12. Epub 2018 Nov 9.

a Zanjan Pharmaceutical Nanotechnology Research Center , Zanjan University of Medical Sciences , Zanjan , Iran.

This study is a report about the synthesis iron oxide magnetic nanoparticles (IONPs) which modified with positive and negative charged amino acids (AAs). l-Arginine (Arg) and l-aspartic acid (Asp) which have of guanidinium and carboxylic acid groups, respectively, were selected for this study. After loading chrysin in amino acids modified iron oxide magnetic nanoparticles (F@AAs@Chrysin NPs), it was characterized by XRD, TGA, FTIR, VSM, and TEM techniques. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/10837450.2018.1
Publisher Site
http://dx.doi.org/10.1080/10837450.2018.1536995DOI Listing
November 2018
19 Reads

Development of a small-scale spray-drying approach for amorphous solid dispersions (ASDs) screening in early drug development.

Pharm Dev Technol 2019 Jun 6;24(5):560-574. Epub 2018 Nov 6.

a School of Pharmacy and Pharmaceutical Sciences, Faculty of Health Sciences and Wellbeing , University of Sunderland , Sunderland , UK.

The present study details the development of a small-scale spray-drying approach for the routine screening of amorphous solid dispersions (ASDs). This strategy aims to overcome the limitations of standard screening methodologies like solvent casting and quench cooling to predict drug-polymer miscibility of spray-dried solid dispersions (SDSDs) and therefore to guarantee appropriate carrier and drug-loading (DL) selection. A DoE approach was conducted to optimize process conditions of ProCept 4M8-TriX spray-drying to maximize the yield from a 100 mg batch of Itraconazole/HPMCAS-LF and Itraconazole/Soluplus 40:60 (w/w). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/10837450.2018.1534861DOI Listing
June 2019
3 Reads

Multivariate analysis as a method to understand variability in a complex excipient, and its contribution to formulation performance.

Pharm Dev Technol 2018 Dec 14;23(10):1146-1155. Epub 2018 Nov 14.

d Colorcon , Harleysville , PA , USA.

A key part of the Risk Assessment of excipients is to understand how raw material variability could (or does) contribute to differences in performance of the drug product. Here we demonstrate an approach which achieves the necessary understanding for a complex, functional, excipient. Multivariate analysis (MVA) of the certificates of analysis of an ethylcellulose aqueous dispersion (Surelease) formulation revealed low overall variability of the properties of the systems. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/10837450.2018.1534862DOI Listing
December 2018
5 Reads

Spray coating of foley urinary catheter by chlorhexidine-loadedpoly(ε-caprolactone) nanospheres: effect of lyoprotectants, characteristics, and antibacterial activity evaluation.

Pharm Dev Technol 2019 Apr 22;24(4):402-409. Epub 2018 Oct 22.

a Department of Biomedical Engineering, Faculty of Engineering , Mahidol University , Nakhon Pathom , Thailand.

In this study, chlorhexidine-loaded poly(ε-caprolactone) nanospheres (CHX-NS) were prepared and successfully coated on the urinary catheters. Properties of CHX-NS were evaluated including drug loading content and the nanosphere size. Effects of different lyoprotectants for long-term storage of CHX-NS were also investigated. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/10837450.2018.1
Publisher Site
http://dx.doi.org/10.1080/10837450.2018.1502317DOI Listing
April 2019
5 Reads

New in-situ gelling biopolymer-based matrix for bioavailability enhancement of glimepiride; in-vitro/in-vivo x-ray imaging and pharmacodynamic evaluations.

Pharm Dev Technol 2019 Jun 27;24(5):539-549. Epub 2018 Sep 27.

a Department of Pharmaceutics, Faculty of Pharmacy , Mansoura University , Mansoura , Egypt.

Glimepiride (Gmp) a third generation of sulphonylurea is a weakly acidic hypoglycemic drug that belongs to Biopharmaceutical Classification System (BCS) class II. It suffers from poor solubility as well as erratic and variable therapeutic effect. The authors investigated the feasibility of utilizing two nontoxic and biodegradable biopolymers (casein (CA) and chitosan (CT)) as a new in-situ gelling tablet matrix to circumvent this limitation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/10837450.2018.1517366DOI Listing
June 2019
4 Reads