1,872 results match your criteria Pharmaceutical Development and Technology [Journal]


Multiple Linear Regression Applied to Predicting Droplet Size of Complex Perfluorocarbon Nanoemulsions for Biomedical Applications.

Pharm Dev Technol 2019 Feb 6:1-36. Epub 2019 Feb 6.

a Graduate School of Pharmaceutical Sciences , Duquesne University , 600 Forbes Avenue , Pittsburgh , PA 15282 , USA.

Multiple linear regression (MLR) modeling as a novel methodological advancement for design, development and optimization of perfluorocarbon nanoemulsions (PFC NEs) is presented. The goal of the presented work is to develop MLR methods applicable to design, development and optimization of PFC NEs in broad range of biomedical uses. Depending on the intended use of PFC NEs as either therapeutics or diagnostics, nanoemulsion composition differs in respect to specific applications (e. Read More

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http://dx.doi.org/10.1080/10837450.2019.1578372DOI Listing
February 2019
1 Read

Application of a quality-by-design approach for utilizing sodium stearyl fumarate as a taste-masking agent in dextromethorphan hydrobromide orally disintegrating tablets.

Pharm Dev Technol 2019 Feb 4:1-33. Epub 2019 Feb 4.

a Department of Pharmaceutics , College of Pharmacy, King Saud University , Riyadh , Kingdom of Saudi Arabia.

Orally dissolving tablets (ODTs) represent one of the recent advances in drug delivery. The foremost objective of this study was to optimize the utilization of lubricant sodium stearyl fumarate in the preparation of dextromehorphan hydrobromide ODTs with enhanced taste-masking properties. Simple blending of sodium stearyl fumarate with the powder bed would result in taste-masking through physical adsorption of the lubricant particles on the drug particles. Read More

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https://www.tandfonline.com/doi/full/10.1080/10837450.2019.1
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http://dx.doi.org/10.1080/10837450.2019.1579228DOI Listing
February 2019
5 Reads

Evaluation of Topical Econazole Nitrate Formulations with Potential for Treating Raynaud's Phenomenon.

Pharm Dev Technol 2019 Feb 4:1-36. Epub 2019 Feb 4.

b Department of Medicine, Division of Rheumatology , University of Toledo , Toledo , USA.

Asbtract The purpose of this work was to design and characterize a topical formulation of econazole nitrate (EN) with potential for treating Raynaud's phenomenon (RP). Four topical dosage forms (F1_topical solution, F2_HPMC or hydroxypropyl methylcellulose dispersion, F3_ VersaBase cream and F4Lipoderm Activemax™ Cream) containing 3% w/w EN were prepared and characterized for drug content, pH, viscosity, spreadability, drug crystallinity, stability and in vitro permeation using Franz cells across pig ear skin, and results were compared to the 1% marketed EN cream. All four formulations had acceptable physical and visual characteristics required for topical application, with 3% w/w EN. Read More

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http://dx.doi.org/10.1080/10837450.2019.1578371DOI Listing
February 2019

Hyaluronic acid gel-core liposomes (hyaluosomes) enhance skin permeation of ketoprofen.

Pharm Dev Technol 2019 Jan 24:1-25. Epub 2019 Jan 24.

b Pharmaceutics Department, Faculty of Pharmacy , Minia University , Minia , Egypt.

Since FDA approval of the first transdermal patch in 1979, the utilizing of skin as a route of systemic drug administration has attracted the attention of the formulation scientists. The liposomes research in the area of transdermal drug delivery has been around for decades. This study aimed at comparing the latest gel-core liposomes (hyaluosomes) with non-conventional liposomal systems such as propylene glycol (PG)-liposomes, ethosomes, transferosomes and conventional liposomes loaded with ketoprofen. Read More

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http://dx.doi.org/10.1080/10837450.2019.1572761DOI Listing
January 2019
1 Read

Pegylated magnetic mesoporous silica nanoparticles decorated with AS1411 Aptamer as a targeting delivery system for cytotoxic agents.

Pharm Dev Technol 2019 Jan 18:1-36. Epub 2019 Jan 18.

a Nanotechnology Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences , Tehran , Iran.

Fulfilling the purpose of developing a NP with theragnostic capabilities, the current study describes synthesis of an aptamer-functionalized PEG-coated SPION/mesoporous silica core-shell nanoparticle for concurrent cancer targeted therapy and magnetic resonance imaging. SPIONs were synthesized according to a thermal decomposition method and served as cores for SPION/mesoporous silica core/shell nanoparticles (MMSNs). Doxorubicin was then successfully loaded in MMSNs which were then coated with di-carboxylic acid functionalized poly ethylene glycol (PEG-MMSNs). Read More

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https://www.tandfonline.com/doi/full/10.1080/10837450.2019.1
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http://dx.doi.org/10.1080/10837450.2019.1569678DOI Listing
January 2019
9 Reads
1.335 Impact Factor

Study of biodistribution and systemic toxicity of glucose functionalized SPIO/DOX micelles.

Pharm Dev Technol 2019 Jan 17:1-35. Epub 2019 Jan 17.

a Department of Biomedical Engineering, Faculty of Engineering , Mahidol University , Puttamonthon , Nakorn Pathom 73170 , Thailand.

The present study examined the cytotoxicity and magnetic resonance imaging (MRI) distribution of cancer-targeted, MRI-visible polymeric micelles that encapsulate doxorubicin (DOX) and superparamagnetic iron oxide (SPIO) and are conjugated with glucose as a targeting ligand. In this study, the micelles were characterized by dynamic light scattering to determine particle size and zeta potential. Morphology and structure of the micelles were evaluated by transmission electron microscopy. Read More

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https://www.tandfonline.com/doi/full/10.1080/10837450.2019.1
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http://dx.doi.org/10.1080/10837450.2019.1569679DOI Listing
January 2019
5 Reads

Elucidating Spray Dried Dispersion Dissolution Mechanisms with Focused Beam Reflectance Measurement: Contribution of Polymer Chemistry and Particle Properties to Performance.

Pharm Dev Technol 2019 Jan 14:1-25. Epub 2019 Jan 14.

d Bristol-Myers Squibb, Drug Product Science and Technology , Reeds Lane, Moreton , liverpool , CH46 1QW United Kingdom of Great Britain and Northern Ireland.

Amorphous spray dried dispersions (SDDs) are a key enabling technology for oral solid dosage formulations, used to improve dissolution behaviour and clinical exposure of poorly-soluble active pharmaceutical ingredients (APIs). Appropriate assessment of amorphous dissolution mechanisms is an ongoing challenge. Here we outline the novel application using Focused Beam Reflectance Measurement (FBRM) to analyse particle populations orthogonal to USP 2 dissolution. Read More

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http://dx.doi.org/10.1080/10837450.2018.1559189DOI Listing
January 2019
2 Reads

Comparison of Cationic Liposome and PAMAM Dendrimer for Delivery of Anti-Plk1 siRNA in Breast Cancer Treatment.

Pharm Dev Technol 2019 Jan 11:1-27. Epub 2019 Jan 11.

a Department of Pharmaceutics , National Institute of Pharmaceutical Education and Research (NIPER) , Hyderabad 500037 , India.

Delivery of negatively charged, high molecular weight and unstable siRNA is difficult. The present study describes the development and comparison of cationic liposomes (CLs) and polyamidoamine (PAMAM) dendrimer generation 4 (PG4) nanocarriers of gene for cancer therapy. CLs and PG4 were complexed with anticancer siRNA (siPlk1) to form siPlk1-CLs lipoplex and siPlk1-PG4 dendriplex. Read More

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https://www.tandfonline.com/doi/full/10.1080/10837450.2019.1
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http://dx.doi.org/10.1080/10837450.2019.1567763DOI Listing
January 2019
5 Reads

Characterization and pharmacokinetic evaluation of microcomposite particles of alpha lipoic acid/hydrogenated colza oil obtained in supercritical carbon dioxide.

Pharm Dev Technol 2019 Jan 11:1-29. Epub 2019 Jan 11.

j Department of Applied Chemistry, Faculty of Engineering , Oita University , 700 Dannoharu Oita-shi , 870-1192 , Japan.

The work reported here is an extension of our previous findings in which supercritical composite particles (SCP) of alpha lipoic acid (ALA) masked with hydrogenated colza oil (HCO) named as ALA/HCO/SCP were obtained by the modified particles from gas-saturated solutions (PGSS) process in supercritical carbon dioxide in order to obscure the unpleasant taste and odor of ALA. The masking effect on ALA/HCO/SCP was compared with the widely used mechano-chemiclally masked formulation of ALA and HCO named as MC-50F. In the present study, ALA/HCO/SCP particles were found to have a significant improvement in regard to bitterness, numbness, and smell compared to ALA bulk powders suggesting they were well coated. Read More

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http://dx.doi.org/10.1080/10837450.2019.1567760DOI Listing
January 2019
1 Read

Spray-Dried Alginate Microparticles for Potential Intranasal Delivery of Ropinirole Hydrochloride: Development, Characterization and Histopathological Evaluation.

Pharm Dev Technol 2019 Jan 10:1-36. Epub 2019 Jan 10.

f School of Mathematics and Physics, College of Science, University of Lincoln , UK.

Ropinirole hydrochloride (RH) is an anti-Parkinson drug with relativity low oral bioavailability owing to its extensive hepatic first pass metabolism. Spray-dried mucoadhesive alginate microspheres of RH were developed and characterized followed by histopathological evaluation using nasal tissue isolated from sheep. Spherical microparticles having high product yield (around 70%) were obtained when the inlet temperature of spray drying was 140 °C. Read More

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https://www.tandfonline.com/doi/full/10.1080/10837450.2019.1
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http://dx.doi.org/10.1080/10837450.2019.1567762DOI Listing
January 2019
2 Reads

Preparation and Characterization of Angiopep-2 Functionalized Ginsenoside-Rg3 Loaded Nanoparticles and the Effect on C6 Glioma Cells.

Pharm Dev Technol 2019 Jan 2:1-37. Epub 2019 Jan 2.

c Department of Pharmacy , Hebei North University , Zhangjiakou , China .

The purpose of this work was to prepare and characterize Angiopep-2 functionalized ginsenoside-Rg3 loaded nanoparticles (ANG-Rg3-NP) and evaluate the therapeutic effect on C6 glioma cells. Nanoparticles were prepared by the emulsion solvent evaporation method. Angiopep-2 was functionalized to nanoparticles via a maleimide-thiol covalent binding reaction to obtain ANG-Rg3-NP. Read More

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http://dx.doi.org/10.1080/10837450.2018.1551901DOI Listing
January 2019
1 Read

Preparation and in vitro / in vivo evaluation of 6-Gingerol TPGS/PEG-PCL polymeric micelles.

Pharm Dev Technol 2018 Dec 17:1-30. Epub 2018 Dec 17.

a Department of Pharmaceutics, School of Pharmacy, Center for Nano Drug/Gene Delivery and Tissue Engineering , Jiangsu University , Zhenjiang 212013 , People's Republic of China.

6-Gingerol, an active herbal ingredient of ginger, has various bioactivities such as anti-neurodegenerative disease, anti-inflammatory and so on. The aim of the present study was to enhance the oral bioavailability and brain distribution of 6-Gingerol via polymeric micelles. A polymeric micelles drug delivery system of 6-Gingerol consisting of D-α-Tocopheryl polyethylene glycol 1000 succinate (TPGS) and Poly (ethylene glycol)-poly (ε-caprolactone) (PEG-PCL) was prepared via solvent injection method. Read More

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http://dx.doi.org/10.1080/10837450.2018.1558239DOI Listing
December 2018
1 Read
1.335 Impact Factor

Controlling the Internal Morphology of Aqueous Core-PLGA Shell Microcapsules: Promoting the Internal Phase Separation via Alcohol Addition.

Pharm Dev Technol 2018 Dec 17:1-33. Epub 2018 Dec 17.

a School of Pharmacy , The University of Jordan , Amman 11942 Jordan.

The ability to control the internal core architecture of polymeric microcapsules has a direct impact on their applications. However, this task, especially to produce microcapsules with a high percentage of mononuclear aqueous cores, proved to be challenging. In this work, and in continuation to our previous studies, we report a facile protocol to prepare poly(D,L-lactide-co-glycolide) (PLGA) microcapsules with unprecedented percentage (almost 100%) of mononuclear aqueous cores by the internal phase separation method via adding alcohols. Read More

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https://www.tandfonline.com/doi/full/10.1080/10837450.2018.1
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http://dx.doi.org/10.1080/10837450.2018.1558238DOI Listing
December 2018
8 Reads

Effects of silymarin-loaded amphiphilic chitosan polymeric micelles on the renal toxicity and anticancer activity of cisplatin.

Pharm Dev Technol 2018 Dec 7:1-27. Epub 2018 Dec 7.

a Department of Pharmaceutical Technology, Faculty of Pharmacy , Silpakorn University , Nakhon Pathom , 73000 , Thailand.

This research aimed to evaluate the effects of silymarin (SM)-loaded polymeric micelles (PMs) on the renal toxicity and anticancer activity of cisplatin. Amphiphilic chitosan derivatives were employed to develop SM-loaded PMs. The permeation across an intestinal membrane, cytotoxicity, and renal toxicity of cisplatin during the treatment were evaluated. Read More

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http://dx.doi.org/10.1080/10837450.2018.1556690DOI Listing
December 2018
3 Reads
1.335 Impact Factor

In Vivo Study of mPEG-PCL as a Nanocarriers for Anti-Inflammatory Drug Delivery of Simvastatin.

Pharm Dev Technol 2018 Dec 5:1-25. Epub 2018 Dec 5.

e Cancer Gene Therapy Research Center , Zanjan University of Medical Sciences , Zanjan , Iran .

Purpose: In this study, methoxy poly (ethylene glycol) -poly (ε-caprolactone) (mPEG-PCL) di block copolymers were synthesized. The purpose of this work is to investigate the in vivo anti-inflammatory effects of simvastatin-loaded micelles.

Methods: The structure of synthesized copolymers were characterized by using HNMR, FTIR and GPC techniques. Read More

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http://dx.doi.org/10.1080/10837450.2018.1556689DOI Listing
December 2018
3 Reads

Optimization of nimesulide-loaded Solid Lipid Nanoparticles (SLN) by factorial design, release profile and cytotoxicity in human colon adenocarcinoma cell line.

Pharm Dev Technol 2018 Nov 26:1-25. Epub 2018 Nov 26.

a Department of Pharmaceutical Technology, Faculty of Pharmacy , University of Coimbra (FFUC), Pólo das Ciências da Saúde, Azinhaga de Santa Comba , 3000-548 Coimbra , Portugal.

The aim of this work has been the development of a non-toxic, long-term stable solid lipid nanoparticles (SLN) formulation for the loading of Nimsulide (NiM) by a 2 factorial design. The optimized formulation was composed of 10 wt% of glyceryl behenate and 2.5 wt% of poloxamer 188. Read More

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https://www.tandfonline.com/doi/full/10.1080/10837450.2018.1
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http://dx.doi.org/10.1080/10837450.2018.1549075DOI Listing
November 2018
4 Reads

Pre-formulation investigations for establishing a protocol for treosulfan handling and activation.

Pharm Dev Technol 2019 Jan 10:1-10. Epub 2019 Jan 10.

d Department of Oncology and Pathology , Karolinska Institutet , Stockholm , Sweden.

Introduction: Treosulfan is an alkylating agent that is used for the treatment of ovarian cancer and for conditioning prior to stem cell transplantation. It is a prodrug that is activated non-enzymatically to two active epoxides.

Objectives: To optimize a protocol for both in vivo samples handling and in vitro drug preparation. Read More

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http://dx.doi.org/10.1080/10837450.2018.1551903DOI Listing
January 2019
2 Reads
1.335 Impact Factor

Effects of formulation development methods on the stability of model protein pharmaceuticals embedded in solid lipid matrices.

Pharm Dev Technol 2018 Nov 26:1-14. Epub 2018 Nov 26.

b School of Pharmacy , University of Otago , Dunedin , New Zealand.

This study was conducted to investigate the influence of formulation development methods on the stability (secondary structure, aggregation, and biological activity) of protein drugs embedded in lipid matrices. Catalase, horseradish peroxidase, and α-chymotrypsin were employed as model proteins, while Precirol® AT05 (glyceryl palmitostearate) was used as lipid matrix. Protein-loaded lipid matrices were prepared using melting and mixing and wet granulation methods. Read More

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http://dx.doi.org/10.1080/10837450.2018.1551902DOI Listing
November 2018
1 Read

Brinzolamide-loaded nanoemulsions: Ex vivo transcorneal permeation, cell viability and ocular irritation tests.

Pharm Dev Technol 2018 Nov 24:1-23. Epub 2018 Nov 24.

d Buchanan Ocular Therapeutics Unit, Department of Ophthalmology, New Zealand National Eye Centre, Faculty of Medical and Health Sciences , University of Auckland , Auckland , New Zealand .

The aim of this study was to investigate the corneal penetration of brinzolamide nanoemulsions and evaluate their in vitro and ex vivo irritancy potential. Twelve brinzolamide nanoemulsions were prepared by the spontaneous emulsification method and ex vivo permeability studies were conducted using excised bovine corneas fixed onto Franz diffusion cells. To confirm the safety of the formulations for ophthalmic use, preparations were examined for potential ocular irritancy using a cell viability assay on retinal cells, the hen's egg test-chorioallantoic membrane (HET-CAM) and the bovine corneal opacity-permeability (BCOP) test. Read More

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https://www.tandfonline.com/doi/full/10.1080/10837450.2018.1
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http://dx.doi.org/10.1080/10837450.2018.1547748DOI Listing
November 2018
7 Reads

Clarithromycin Laurate Salt: Physicochemical Properties and Pharmacokinetics after Oral Administration in Humans.

Pharm Dev Technol 2018 Nov 25:1-15. Epub 2018 Nov 25.

g Al Taqaddom Pharmaceuticals , Amman , Jordan.

Clarithromycin laurate (CLM-L), a fatty acid salt of clarithromycin (CLM), was prepared by a simple co-melting process. The formation of CLM-L was confirmed using FTIR, H NMR, and C NMR. Solubility, intrinsic dissolution rate (IDR), and partitioning properties of CLM-L were determined and compared to those of CLM. Read More

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https://www.tandfonline.com/doi/full/10.1080/10837450.2018.1
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http://dx.doi.org/10.1080/10837450.2018.1547749DOI Listing
November 2018
10 Reads
1.335 Impact Factor

Increased in vitro leishmanicidal activity of octyl gallate loaded poly(methyl methacrylate) nanoparticles.

Pharm Dev Technol 2018 Nov 20:1-25. Epub 2018 Nov 20.

a Department of Food and Chemical Engineering , Federal University of Santa Catarina , Brazil.

The current paucity of effective and affordable drugs for the treatment of leishmaniasis renders the search for new therapeutic alternatives a priority. Gallic acid related compounds display anti-parasitic activities and their incorporation into drug carrier systems, such as polymeric nanoparticles may be a viable alternative for leishmaniasis treatment. Therefore, this study focused on the synthesis and characterization of octyl gallate (G8) loaded poly(methyl methacrylate) (PMMA) nanoparticles via miniemulsion polymerization in order to increase the leishmanicidal activity of this compound. Read More

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http://dx.doi.org/10.1080/10837450.2018.1547747DOI Listing
November 2018
9 Reads

Silk fibroin nanoparticles for enhanced bio-macromolecule delivery to the retina.

Pharm Dev Technol 2018 Nov 20:1-35. Epub 2018 Nov 20.

a School of Pharmaceutical Sciences , Sun Yat-Sen University , Guangzhou 510006 , China.

The aim of this study was to investigate intravitreal injection of silk fibroin nanoparticles (SFNs) encapsulating bio-macromolecules, achieving enhanced drug bioavailability and extended retention in retina. SFNs were prepared with regenerated silk fibroin (RSF) using desolvation method with fluorescein isothiocyanate labeled bovine serum albumin (FITC-BSA) as bio-macromolecular model drug encapsulated. In vitro physicochemical properties and in vitro drug release of FITC-BSA loaded SFNs (FITC-BSA-SFNs) were evaluated. Read More

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https://www.tandfonline.com/doi/full/10.1080/10837450.2018.1
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http://dx.doi.org/10.1080/10837450.2018.1545236DOI Listing
November 2018
7 Reads

Influence of Protamine Shell on Nanoemulsions as a Carrier for Cyclosporine-a Skin Delivery.

Pharm Dev Technol 2018 11 20:1-31. Epub 2018 Nov 20.

a Departamento de Farmacia, Facultad de Química , Pontificia Universidad Católica de Chile , Santiago , Chile ;

Novel protamine based nanosystems have been studied for cyclosporine-A (CsA) skin delivery. Core-shell structure systems have been developed to this end. These vehicles have particles sizes of 200-300 nm, a low polydispersity index and a zeta potential which varies between -16 mV and +35 mV. Read More

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http://dx.doi.org/10.1080/10837450.2018.1550789DOI Listing
November 2018
1 Read

In-vivo anti-tumor activity of a novel poloxamer-based thermosensitive in situ gel for sustained delivery of norcantharidin.

Pharm Dev Technol 2018 Nov 20:1-22. Epub 2018 Nov 20.

b Department of Pharmacy , Zhejiang Cancer Hospital , Hangzhou , 310022 , Zhejiang , PR China .

In order to develop a novel norcantharidin (NCTD) delivery system with slow drug release and specific targeting characteristics, we have developed a Poloxamer-based NCTD thermosensitive in situ gel. The evaluation of the characteristics of this system using both in vitro and in vivo methods was previously reported. However, its anti-tumor activity in vivo is still not confirmed. Read More

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https://www.tandfonline.com/doi/full/10.1080/10837450.2018.1
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http://dx.doi.org/10.1080/10837450.2018.1550788DOI Listing
November 2018
2 Reads

Optimization of a dry powder inhaler of ciprofloxacin-loaded polymeric nanomicelles by spray drying process.

Pharm Dev Technol 2018 Nov 15:1-33. Epub 2018 Nov 15.

a Department of Pharmaceutics, School of Pharmacy , Shahid Beheshti University of Medical Sciences , Tehran , Iran.

Ciprofloxacin is a commonly prescribed antibiotic for treatment of pulmonary infections. Nanocarriers such as nanomicelles can increase the drug residence time in the lungs and enhance their antibacterial effects. Dry powder inhalers (DPIs) are the preferred pulmonary drug delivery system and preparation of an optimum nanoaggregate from nanomicelles by means of spray drying would be valuable. Read More

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https://www.tandfonline.com/doi/full/10.1080/10837450.2018.1
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http://dx.doi.org/10.1080/10837450.2018.1545237DOI Listing
November 2018
8 Reads

Preparation and in vivo pharmacokinetics of rhGH-loaded PLGA microspheres.

Pharm Dev Technol 2018 Nov 13:1-7. Epub 2018 Nov 13.

b School of Pharmaceutical Sciences , Peking University , Beijing , China.

Recombinant human growth hormone (rhGH) therapy must be administered as a daily injection due to its short half-life. To achieve sustained release of rhGH, the preparation of rhGH-loaded PLGA microspheres was investigated, and the influence of various factors on encapsulation efficiency was tested, including rhGH concentration, the ratio of internal phase to organic phase, stirring speed, PVA concentration, surrounding pH value, and the type of emulsifier and organic solvent. A pharmacokinetic study was performed by subcutaneous administration to explore the sustained release effect. Read More

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https://www.tandfonline.com/doi/full/10.1080/10837450.2018.1
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http://dx.doi.org/10.1080/10837450.2018.1502316DOI Listing
November 2018
5 Reads

On the plasticizing properties of divalproex sodium: physicochemical and spectroscopic characterization studies.

Pharm Dev Technol 2018 Nov 6:1-10. Epub 2018 Nov 6.

b Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers , The State University of New Jersey , Piscataway , NJ , USA.

The objective of the research was to demonstrate the plasticization properties of divalproex sodium, due to its component-valproic acid, on ethyl cellulose, which could prove beneficial for film fabrications or hot melt extrusion based formulations. Films containing 10-50% w/w (DVS/EC) as dry weight were prepared using solvent evaporation method and characterized using texture analyzer, hybrid rheometer, differential scanning calorimetry, thermogravimetry, X-ray diffractometry, polarized microscopy, FTIR, and Raman spectroscopy. It was found that there was a decrease in average peak load, melt viscosity, and glass transition temperature (T) while increase in elongation, with increase in concentration of DVS in the films. Read More

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https://www.tandfonline.com/doi/full/10.1080/10837450.2018.1
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http://dx.doi.org/10.1080/10837450.2018.1514049DOI Listing
November 2018
7 Reads

Controlled release drug delivery systems.

Authors:
Paul W S Heng

Pharm Dev Technol 2018 11;23(9):833

a GEA-NUS Pharmaceutical Processing Research Laboratory, Department of Pharmacy , National University of Singapore.

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http://dx.doi.org/10.1080/10837450.2018.1534376DOI Listing
November 2018
1 Read

Physiological Parameters of the Gastrointestinal Fluid Impact the Dissolution Behavior of the BCS Class IIa Drug Valsartan.

Authors:
Rania Hamed

Pharm Dev Technol 2018 Oct 15:1-31. Epub 2018 Oct 15.

a Department of Pharmacy, Faculty of Pharmacy , Al-Zaytoonah University of Jordan , Amman , Jordan.

The objective of this study was to investigate the effect of the physiological parameters (pH, buffer capacity, and ionic strength) of the gastrointestinal (GI) fluid on the dissolution behavior of the class II weakly acidic (BCS class IIa) drug valsartan. A series of in vitro dissolution studies was carried out on Diovan® immediate release tablets using media that cover the physiological range of pH (1.2 - 7. Read More

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https://www.tandfonline.com/doi/full/10.1080/10837450.2018.1
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http://dx.doi.org/10.1080/10837450.2018.1536996DOI Listing
October 2018
13 Reads

Manufacturing classification system in the real world: factors influencing manufacturing process choices for filed commercial oral solid dosage formulations, case studies from industry and considerations for continuous processing.

Pharm Dev Technol 2018 Dec 13;23(10):964-977. Epub 2018 Nov 13.

i Curso de Farmácia, Centro de Ciências Biológicas e da Saúde , Universidade de Caxias do Sul , Caxias do Sul , Brazil.

Following the first Manufacturing Classification System (MCS) paper, the team conducted surveys to establish which active pharmaceutical ingredient (API) properties were important when selecting or modifying materials to enable an efficient and robust pharmaceutical manufacturing process. The most commonly identified factors were (1) API particle size: small particle sizes are known to increase risk of processing issues; (2) Drug loading in the formulation: high drug loadings allow less opportunity to mitigate poor API properties through the use of excipients. The next step was to establish linkages with process decisions by identifying publicly-available proxies for these important parameters: dose (in place of drug loading) and BCS class (in place of particle size). Read More

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https://www.tandfonline.com/doi/full/10.1080/10837450.2018.1
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http://dx.doi.org/10.1080/10837450.2018.1534863DOI Listing
December 2018
14 Reads
1.340 Impact Factor

Preparation, characterization, and evaluation of amino acid modified magnetic nanoparticles: drug delivery and MRI contrast agent applications.

Pharm Dev Technol 2018 Nov 9:1-12. Epub 2018 Nov 9.

a Zanjan Pharmaceutical Nanotechnology Research Center , Zanjan University of Medical Sciences , Zanjan , Iran.

This study is a report about the synthesis iron oxide magnetic nanoparticles (IONPs) which modified with positive and negative charged amino acids (AAs). l-Arginine (Arg) and l-aspartic acid (Asp) which have of guanidinium and carboxylic acid groups, respectively, were selected for this study. After loading chrysin in amino acids modified iron oxide magnetic nanoparticles (F@AAs@Chrysin NPs), it was characterized by XRD, TGA, FTIR, VSM, and TEM techniques. Read More

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https://www.tandfonline.com/doi/full/10.1080/10837450.2018.1
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http://dx.doi.org/10.1080/10837450.2018.1536995DOI Listing
November 2018
14 Reads

Development of a small-scale spray-drying approach for amorphous solid dispersions (ASDs) screening in early drug development.

Pharm Dev Technol 2018 Nov 6:1-15. Epub 2018 Nov 6.

a School of Pharmacy and Pharmaceutical Sciences, Faculty of Health Sciences and Wellbeing , University of Sunderland , Sunderland , UK.

The present study details the development of a small-scale spray-drying approach for the routine screening of amorphous solid dispersions (ASDs). This strategy aims to overcome the limitations of standard screening methodologies like solvent casting and quench cooling to predict drug-polymer miscibility of spray-dried solid dispersions (SDSDs) and therefore to guarantee appropriate carrier and drug-loading (DL) selection. A DoE approach was conducted to optimize process conditions of ProCept 4M8-TriX spray-drying to maximize the yield from a 100 mg batch of Itraconazole/HPMCAS-LF and Itraconazole/Soluplus 40:60 (w/w). Read More

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http://dx.doi.org/10.1080/10837450.2018.1534861DOI Listing
November 2018
3 Reads

Multivariate analysis as a method to understand variability in a complex excipient, and its contribution to formulation performance.

Pharm Dev Technol 2018 Dec 14;23(10):1146-1155. Epub 2018 Nov 14.

d Colorcon , Harleysville , PA , USA.

A key part of the Risk Assessment of excipients is to understand how raw material variability could (or does) contribute to differences in performance of the drug product. Here we demonstrate an approach which achieves the necessary understanding for a complex, functional, excipient. Multivariate analysis (MVA) of the certificates of analysis of an ethylcellulose aqueous dispersion (Surelease) formulation revealed low overall variability of the properties of the systems. Read More

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http://dx.doi.org/10.1080/10837450.2018.1534862DOI Listing
December 2018
5 Reads

Spray coating of foley urinary catheter by chlorhexidine-loadedpoly(ε-caprolactone) nanospheres: effect of lyoprotectants, characteristics, and antibacterial activity evaluation.

Pharm Dev Technol 2018 Oct 22:1-8. Epub 2018 Oct 22.

a Department of Biomedical Engineering, Faculty of Engineering , Mahidol University , Nakhon Pathom , Thailand.

In this study, chlorhexidine-loaded poly(ε-caprolactone) nanospheres (CHX-NS) were prepared and successfully coated on the urinary catheters. Properties of CHX-NS were evaluated including drug loading content and the nanosphere size. Effects of different lyoprotectants for long-term storage of CHX-NS were also investigated. Read More

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https://www.tandfonline.com/doi/full/10.1080/10837450.2018.1
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http://dx.doi.org/10.1080/10837450.2018.1502317DOI Listing
October 2018
4 Reads

New in-situ gelling biopolymer-based matrix for bioavailability enhancement of glimepiride; in-vitro/in-vivo x-ray imaging and pharmacodynamic evaluations.

Pharm Dev Technol 2018 Sep 27:1-11. Epub 2018 Sep 27.

a Department of Pharmaceutics, Faculty of Pharmacy , Mansoura University , Mansoura , Egypt.

Glimepiride (Gmp) a third generation of sulphonylurea is a weakly acidic hypoglycemic drug that belongs to Biopharmaceutical Classification System (BCS) class II. It suffers from poor solubility as well as erratic and variable therapeutic effect. The authors investigated the feasibility of utilizing two nontoxic and biodegradable biopolymers (casein (CA) and chitosan (CT)) as a new in-situ gelling tablet matrix to circumvent this limitation. Read More

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http://dx.doi.org/10.1080/10837450.2018.1517366DOI Listing
September 2018
2 Reads

Critical appraisal of commercially available suspending vehicles for extemporaneous compounding of cardiovascular medicines: physical and chemical stability mini review.

Pharm Dev Technol 2018 Dec 20:1-10. Epub 2018 Dec 20.

a Discipline of Pharmacy, School of Health and Biomedical Sciences , RMIT University , Melbourne , VIC , Australia.

Oral liquid formulations are compounded by pharmacists to meet the needs of patients when a suitable commercially available product is not available. To minimize the errors associated with measuring multiple excipients and to enhance the shelf-life of the medicines, commercially available suspending bases are commonly used. This review aims to compare the stability and shelf life of commercially available extemporaneous formulation to traditional formulation methods. Read More

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http://dx.doi.org/10.1080/10837450.2018.1526955DOI Listing
December 2018
11 Reads

Physical Properties and Solubility Studies of Nifedipine-PEG 1450/HPMCAS-HF Solid Dispersions.

Pharm Dev Technol 2018 Sep 3:1-23. Epub 2018 Sep 3.

a College of Pharmacy & Health Sciences, Campbell University , Buies Creek , NC 27506 , USA.

Low-order high-energy nifedipine (NIF) solid dispersions (SDs) were generated by melt solvent amorphization with PEG 1450 and HPMCAS-HF to increase NIF solubility while achieving acceptable physical stability. HPMCAS-HF was used as a crystallization inhibitor. Individual formulation components, their physical mixtures (PMs), and SDs were characterized by DSC, PXRD, and FTIR. Read More

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http://dx.doi.org/10.1080/10837450.2018.1519573DOI Listing
September 2018
13 Reads

Development of filaments for fused deposition modeling 3D printing with medical grade poly(lactic-co-glycolic acid) copolymers.

Pharm Dev Technol 2018 Sep 25:1-7. Epub 2018 Sep 25.

a Department of Biochemical and Chemical Engineering , TU Dortmund University , Dortmund , Germany.

The manufacturing of custom implants and patient-tailored drug dosage forms with fused deposition modeling (FDM) three-dimensional (3D) printing is currently considered to be very promising. Most FDM printers are designed as an open filament system, for which filaments with a defined size are required. In addition to this processing requirement, the filament material must be of medical or pharmaceutical quality, in order to be suitable in these applications. Read More

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http://dx.doi.org/10.1080/10837450.2018.1514522DOI Listing
September 2018
4 Reads

Solubilization of the chlorin TPCS in the presence of Pluronic F127/Tween 80 mixtures.

Pharm Dev Technol 2018 Sep 26:1-8. Epub 2018 Sep 26.

c School of Pharmacy, Department of Pharmacy - Division Pharmaceutics - PharmaLuxLab , University of Oslo , Oslo , Norway.

The efficacy of surfactant mixtures of Pluronic F127 and Tween 80 at overall concentration in the micromolar range and molar ratio 1:1, 1:10, and 10:1 in inhibiting aggregation of the photosensitizer meso-tetraphenyl chlorin disulphonate (TPCS) was investigated in aqueous media at pH 2.9 by means of steady-state absorption and fluorescence emission spectroscopy as well as time-resolved fluorescence analysis. Corresponding experiments were performed at pH 7. Read More

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https://www.tandfonline.com/doi/full/10.1080/10837450.2018.1
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http://dx.doi.org/10.1080/10837450.2018.1515955DOI Listing
September 2018
29 Reads

Mucoadhesive chitosan-coated nanostructured lipid carriers for oral delivery of amphotericin B.

Pharm Dev Technol 2018 Sep 26:1-9. Epub 2018 Sep 26.

a School of Pharmacy , University of Nottingham , Semenyih , Malaysia.

This study describes the properties of an amphotericin B-containing mucoadhesive nanostructured lipid carrier (NLC), with the intent to maximize uptake within the gastrointestinal tract. We have reported previously that lipid nanoparticles can significantly improve the oral bioavailability of amphotericin B (AmpB). On the other hand, the aggregation state of AmpB within the NLC has been ascribed to some of the side effects resulting from IV administration. Read More

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http://dx.doi.org/10.1080/10837450.2018.1515225DOI Listing
September 2018
17 Reads
1.340 Impact Factor

Effect of sulfobutyl ether-β-cyclodextrin and propylene glycol alginate on the solubility of clozapine.

Pharm Dev Technol 2018 Sep 11:1-8. Epub 2018 Sep 11.

a Department of Physical Chemistry, School of Pharmacy and Pharmaceutical Sciences , Hoshi University , Tokyo , Japan.

Clozapine (CLZ) is an atypical antipsychotic medication used in the treatment of schizophrenia and is poorly soluble in water (0.05 mM). In this study, we have investigated the effect of β-cyclodextrin (CD) and its derivatives on the solubility of CLZ. Read More

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http://dx.doi.org/10.1080/10837450.2018.1514521DOI Listing
September 2018
2 Reads

Montelukast nasal spray: formulation development and in vitro evaluation.

Pharm Dev Technol 2018 Sep 27:1-10. Epub 2018 Sep 27.

a Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences , Prince of Songkla University , Hat Yai , Songkhla , Thailand.

Objectives: The aim of this study was to evaluate potential development of montelukast sodium (MTS) as a nasal spray.

Materials And Methods: The formulations were prepared using hydroxypropyl cellulose (HPC) and carbomer 940 (C940). The prepared formulations were evaluated for clarity, pH, hydrodynamic size, zeta potential, viscosity, contact angle, surface tension, droplet size distribution, muco-adhesiveness, drug release, and stability. Read More

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https://www.tandfonline.com/doi/full/10.1080/10837450.2018.1
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http://dx.doi.org/10.1080/10837450.2018.1514523DOI Listing
September 2018
33 Reads
1.340 Impact Factor

Physicochemical and microbiological stability of two news oral liquid formulations of clonidine hydrochloride for pediatric patients.

Pharm Dev Technol 2018 Nov 19:1-14. Epub 2018 Nov 19.

a Unidad de Gestión Clínica de Farmacia, Hospital Universitario Virgen Macarena , Sevilla , Spain.

Pediatric patients present changing physiological features. Because of the lack of land suitable for commercial management, pediatric specialties very often need to prepare extemporaneous formulations to improve the dosage and administration of drugs for children. Oral liquid formulations are the most suitable for pediatric patients. Read More

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http://dx.doi.org/10.1080/10837450.2018.1514520DOI Listing
November 2018
3 Reads

Solubility enhancement and solid-state characterisation.

Authors:
Mike Tobyn

Pharm Dev Technol 2018 09;23(7):663

a Bristol-Myers Squibb Pharmaceuticals , Moreton , UK.

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http://dx.doi.org/10.1080/10837450.2018.1505305DOI Listing
September 2018
2 Reads

The road to market implantable drug delivery systems: a review on US FDA's regulatory framework and quality control requirements.

Pharm Dev Technol 2018 Dec 10;23(10):953-963. Epub 2018 Oct 10.

a School of Pharmacy, Faculty of Medical and Health Sciences , The University of Auckland , Auckland , New Zealand.

The scope of Implantable Drug Delivery Systems (IDDSs) comprehends a variety of sterile therapeutic implements placed inside the body to exert a certain therapeutic action for extended duration. They are classified under different categories from pharmaceutical science and regulatory perspectives. The novelty and variety of IDDSs prevent the application of a uniform regulation for all IDDS products; therefore, sponsors face regulatory challenges to register and market their products. Read More

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http://dx.doi.org/10.1080/10837450.2018.1509348DOI Listing
December 2018
3 Reads

An evaluation of crude palm oil (CPO) and tocotrienol rich fraction (TRF) of palm oil as percutaneous permeation enhancers using full-thickness human skin.

Pharm Dev Technol 2018 Oct 3:1-7. Epub 2018 Oct 3.

a School of Pharmacy , The University of Nottingham Malaysia Campus, Jalan Broga , Semenyih , Malaysia.

The drawbacks associated with chemical skin permeation enhancers such as skin irritation and toxicity necessitated the research to focus on potential permeation enhancers with a perceived lower toxicity. Crude palm oil (CPO) is obtained by direct compression of the mesocarp of the fruit of the oil palm belonging to the genus Elaeis. In this research, CPO and tocotrienol-rich fraction (TRF) of palm oil were evaluated for the first time as skin permeation enhancers using full-thickness human skin. Read More

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http://dx.doi.org/10.1080/10837450.2018.1509347DOI Listing
October 2018
22 Reads

Acoustic emission detection of crystallization in two forms: monohydrate and anhydrous Citric Acid.

Pharm Dev Technol 2018 Aug 3:1-18. Epub 2018 Aug 3.

c Sorbonne Universités, Université Pierre et Matie Curie , Paris 6, Institut Jean le Rond d'Alembert, CNRS UMR 7190, Case 162, 4 Place Jussieu, 75252 Paris Cedex 05 , France.

Reliable monitoring of solution crystallization processes is important to provide further insight into process dynamics and to improve process control in the regimen of Process Analytical Technology (PAT), e.g. as the case studied here: detection of crystallization of the anhydrous and monohydrate forms of Citric Acid (CA). Read More

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http://dx.doi.org/10.1080/10837450.2018.1507037DOI Listing
August 2018
2 Reads

Application of disaccharides alone and in combination, for the improvement of stability and particle properties of spray-freeze dried IgG.

Pharm Dev Technol 2018 Sep 27:1-9. Epub 2018 Sep 27.

a Faculty of Pharmacy, Department of Pharmaceutics , Tehran University of Medical Sciences , Tehran , Iran.

Purpose: Spray-freeze drying (SFD) is a recently applied method to develop pharmaceutical powders. This study aimed to analyze the competence of Trehalose, Mannitol, Lactose, and Sorbitol instability and aerosolization of Immunoglobulin G (IgG) via SFD.

Methods: Induced soluble aggregates were quantified at 0 and 3 months, and 45 °C using size-exclusion chromatography. Read More

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http://dx.doi.org/10.1080/10837450.2018.1507039DOI Listing
September 2018
2 Reads

Sulforaphane-decorated gold nanoparticle for anti-cancer activity: in vitro and in vivo studies.

Pharm Dev Technol 2018 Nov 28:1-12. Epub 2018 Nov 28.

a Department of Pharmaceutics, Faculty of Pharmacy , Jamia Hamdard University , New Delhi , India.

This study aims to develop sulforaphane-loaded gold nanoparticles (SFN-GNPs) as a potential nanomedicine against the solid tumors. Citrate-mediated electrolysis optimized by four-factor three-level Box-Behnken experimental design was used to get nanoparticles of size <200 nm. The formulation was characterized and evaluated for cytotoxicity B16-F10, MCF-7, SW-620 and Caco-2 cell line. Read More

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http://dx.doi.org/10.1080/10837450.2018.1507038DOI Listing
November 2018
3 Reads

The effect of complexation with cyclodextrins on the antioxidant and antimicrobial activity of ellagic acid.

Pharm Dev Technol 2018 Sep 27:1-9. Epub 2018 Sep 27.

a Department of Organic Chemical Technology, Faculty of Technology , University of Nis , Leskovac , Serbia.

Purpose: The aim of the paper was to develop the simple procedures for preparation of inclusion complexes of ellagic acid (EA) with cyclodextrins (CDs) and to investigate their antioxidant and antimicrobial activity.

Methods: The structural characterization was carried out using Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), and nuclear magnetic resonance (NMR) methods. The phase solubility technique was used to investigate the interactions between 'host' and 'guest' molecules and to estimate the molar ratio between them. Read More

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http://dx.doi.org/10.1080/10837450.2018.1502318DOI Listing
September 2018
19 Reads