2,128 results match your criteria Pharmaceutical Biology [Journal]


Larvicidal and ovicidal activities of Artocarpus blancoi extracts against Aedes aegypti.

Pharm Biol 2019 Dec;57(1):120-124

c Faculty of Pharmacy , Meijo University , Nagoya City , Japan.

Context: Dengue control may be done by targeting its vector. In this study, we used Artocarpus blancoi (Elm.) Merr. Read More

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http://dx.doi.org/10.1080/13880209.2018.1561727DOI Listing
December 2019

Hepatoprotective effects of Cassia semen ethanol extract on non-alcoholic fatty liver disease in experimental rat.

Pharm Biol 2019 Dec;57(1):98-104

a Department of Anesthesiology , Qilu Hospital of Shandong University , Shandong , Jinan , People's Republic of China.

Context: Cassia semen (Cs), a seed of Cassia obtusifolia L. (Leguminosae), is a popular functional beverage. Previous studies reported that Cs displayed antioxidant, antifungal and strong liver protective effects. Read More

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http://dx.doi.org/10.1080/13880209.2019.1568509DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374930PMC
December 2019

Eclipta prostrata promotes the induction of anagen, sustains the anagen phase through regulation of FGF-7 and FGF-5.

Pharm Biol 2019 Dec;57(1):105-111

a Division of Applied Medicine, School of Korean Medicine , Pusan National University , Yangsan-si , Republic of Korea.

Context: Eclipta prostrata L. (Asteraceae) (EP) has been widely used for the treatment of skin disease in Asian traditional medicine.

Objective: This study investigates the potency of EP in promoting hair growth in vivo and in vitro. Read More

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http://dx.doi.org/10.1080/13880209.2018.1561729DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374973PMC
December 2019

Inhibitory effects of fucoidan on NMDA receptors and l-type Ca channels regulating the Ca responses in rat neurons.

Pharm Biol 2019 Dec;57(1):1-7

b Photon Medical Research Center , Hamamatsu University School of Medicine , Hamamatsu , Japan.

Context: Fucoidan, a sulphated polysaccharide extracted from brown algae [Fucus vesiculosus Linn. (Fucaceae)], has multiple biological activities.

Objective: The effects of fucoidan on Ca responses of rat neurons and its probable mechanisms with focus on glutamate receptors were examined. Read More

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http://dx.doi.org/10.1080/13880209.2018.1548626DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374951PMC
December 2019

Distributive differences of P2Xs between the forelimb and hind limb of adjuvant arthritis rats and intervention by Notopterygh rhizoma et radix.

Pharm Biol 2019 Dec;57(1):82-89

a College of Pharmacy , Fujian University of Traditional Chinese Medicine , Fuzhou , PR China.

Context: Notopterygium incisum Ting ex H. T. Chang (Umbelliferae) (NI) specializes in treatment of upper limb rheumatoid arthritis (RA), but the exact mechanism is unclear. Read More

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http://dx.doi.org/10.1080/13880209.2018.1561730DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366419PMC
December 2019
2 Reads

Neuronal protective effect of Songling Xuemaikang capsules alone and in combination with carbamazepine on epilepsy in kainic acid-kindled rats.

Pharm Biol 2019 Dec;57(1):22-28

a Department of Pharmacy , Lanzhou University Second Hospital , Lanzhou , China.

Context: Epilepsy is a common life-threatening neurological disorder that is often drug-resistant and associated with cognitive impairment. The traditional Chinese patent medicine Songling Xuemaikang capsules (SXC) is clinically used for epilepsy therapy and alleviation of cognitive impairment.

Objective: This study investigates the neuronal protective effect of SXC combined with carbamazepine (CBZ) on epilepsy and cognitive impairment in kainic acid-kindled SD rats. Read More

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http://dx.doi.org/10.1080/13880209.2018.1563619DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366425PMC
December 2019
1 Read

Effects of Lespedeza Cuneata aqueous extract on testosterone-induced prostatic hyperplasia.

Pharm Biol 2019 Dec;57(1):90-98

b Department of Oriental Medicine Biotechnology , Kyung Hee University , Yongin , Republic of Korea.

Context: Lespedeza cuneata G. Don (Fabaceae), has been used as a traditional treatment of various diseases. There is a report L. Read More

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http://dx.doi.org/10.1080/13880209.2018.1564929DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366415PMC
December 2019
2 Reads

Vitexin as an active ingredient in passion flower with potential as an agent for nicotine cessation: vitexin antagonism of the expression of nicotine locomotor sensitization in rats.

Pharm Biol 2019 Dec;57(1):8-12

a Department of Pharmaceutical Sciences , Campbell University College of Pharmacy & Health Sciences , Buies Creek , NC , USA.

Context: Nicotine, a bioactive component of tobacco, is highly addictive. Numerous therapies have been developed for smoking cessation, and all have met with limited success. Our laboratory has previously shown that an extract of Passiflora incarnata Linn. Read More

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http://dx.doi.org/10.1080/13880209.2018.1561725DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366407PMC
December 2019
1 Read

GABA and l-theanine mixture decreases sleep latency and improves NREM sleep.

Pharm Biol 2019 Dec;57(1):65-73

d Department of Public Health Sciences , Graduate School , Seoul , Republic of Korea.

Context: γ-Aminobutyric acid (GABA) is the main inhibitory neurotransmitter and it is well established that activation of GABA receptors favours sleep. l-Theanine, a naturally occurring amino acid first discovered in green tea, is a well-known anti-anxiety supplement with proven relaxation benefits.

Objective: This study investigated the potential synergistic sleep enhancement effect of GABA/l-theanine mixture. Read More

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https://www.tandfonline.com/doi/full/10.1080/13880209.2018.1
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http://dx.doi.org/10.1080/13880209.2018.1557698DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366437PMC
December 2019
4 Reads

Anti-inflammatory and anti-osteoarthritis effect of Mollugo pentaphylla extract.

Pharm Biol 2019 Dec;57(1):74-81

a Herbal Medicine Research Division , Korea Institute of Oriental Medicine , Daejeon , South Korea.

Context: Mollugo pentaphylla L. (Molluginaceae) extract (MPE) has been reported to have anti-inflammatory effect on MSU-induced gouty arthritis in a mouse model.

Objective: This study examined the anti-inflammatory activities of an MPE in vitro and anti-osteoarthritis effects on monosodium iodoacetate (MIA)-induced osteoarthritis (OA) in vivo. Read More

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http://dx.doi.org/10.1080/13880209.2018.1557700DOI Listing
December 2019

Syzygium aromaticum aqueous extract inhibits human neutrophils myeloperoxidase and protects mice from LPS-induced lung inflammation.

Pharm Biol 2019 Dec;57(1):56-64

a Faculty of Sciences of Gabes , University of Gabes , Gabes , Tunisia.

Context: Syzygium aromaticum (L.) Merr. & Perry (Myrtaceae), commonly known as clove, originally found in the Muluku Islands in East Indonesia, is widely used as a spice and has numerous medicinal properties. Read More

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http://dx.doi.org/10.1080/13880209.2018.1557697DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366422PMC
December 2019

Crataegus Aronia protects and reverses vascular inflammation in a high fat diet rat model by an antioxidant mechanism and modulating serum levels of oxidized low-density lipoprotein.

Pharm Biol 2019 Dec;57(1):38-48

e Department of Biology College of Science, College of Medicine, King Khalid University (KKU), Abha, Saudi Arabia.

Context: Crataegus aronia (Willd.) Bosc (Rosaceae) (syn. Azarolus L) is traditionally used to treat cardiovascular disorders. Read More

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https://www.tandfonline.com/doi/full/10.1080/13880209.2018.1
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http://dx.doi.org/10.1080/13880209.2018.1564930DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366417PMC
December 2019
3 Reads

Analysis of the protective effects of γ-aminobutyric acid during fluoride-induced hypothyroidism in male Kunming mice.

Pharm Biol 2019 Dec;57(1):29-37

a Key Laborotory Experimental Marine Biology, Institute of Oceanology , Chinese Academy of Sciences , Qingdao , China.

Context: Compounds to treat hypothyroidism in the absence of cardiac side effects are urgently required. In this regard, γ-aminobutyric acid (GABA) has gained interest due to its anti-anxiolytic, antihypertensive and antioxidant properties, and reported benefits to the thyroid system.

Objective: We investigated the ability of GABA to ameliorate fluoride-induced thyroid injury in mice, and investigated the mechanism(s) associated with GABA-induced protection. Read More

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http://dx.doi.org/10.1080/13880209.2018.1563621DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346718PMC
December 2019
2 Reads

Resveratrol mitigates the oxidative stress mediated by hypoxic-ischemic brain injury in neonatal rats via Nrf2/HO-1 pathway.

Pharm Biol 2018 Dec;56(1):440-449

a Department of Neurology , Shengjing Hospital Affiliated Hospital of China Medical University , Shenyang, Liaoning , China.

Context: Hypoxic-ischemic encephalopathy (HIE) has a high morbidity and mortality rate. Resveratrol possesses numerous biological properties including antioxidant, anti-inflammatory and neuroprotective activities.

Objective: The current experiment investigates the neuroprotective efficacy of resveratrol (RESV) against HIE by modulating Nrf2/HO-1 pathway in neonatal rats. Read More

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http://dx.doi.org/10.1080/13880209.2018.1502326DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249550PMC
December 2018
12 Reads

Mechanism of TangGanJian on nonalcoholic fatty liver disease with type 2 diabetes mellitus.

Pharm Biol 2018 Dec;56(1):567-572

h Department of Management , Xinjiang Uygur Pharmaceutical Co., Ltd. , Wulumuqi , PR China.

Context: TangGanJian (TGJ) has a curative effect in the clinical treatment of nonalcoholic fatty liver disease (NAFLD) with type 2 diabetes mellitus (T2DM), while the mechanism involved in the treatment process remains unclear.

Objective: This study details the mechanism of TGJ on the treatment of NAFLD with T2DM.

Materials And Methods: NAFLD was induced in T2DM rat model. Read More

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http://dx.doi.org/10.1080/13880209.2018.1504972DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249541PMC
December 2018
16 Reads

Bioactive metabolites from the leaves of Withania adpressa.

Pharm Biol 2018 Dec;56(1):505-510

a Department of Biology, Faculty of Sciences Semlalia, Laboratory of Biotechnology, Protection and Valorisation of Plant Resources (URAC35 association Unit) , Cadi Ayyad University , Marrakech , Morocco.

Context: Withania (Solanaceae) species are known to be a rich source of withanolides, which have shown several biological properties.

Objective: To identify the compounds responsible for Withania adpressa Coss. antioxidant activity and further test them for their NF-κB inhibition and antiproliferative activity in multiple myeloma cells. Read More

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https://www.tandfonline.com/doi/full/10.1080/13880209.2018.1
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http://dx.doi.org/10.1080/13880209.2018.1499781DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249549PMC
December 2018
17 Reads

Ma Huang Tang ameliorates bronchial asthma symptoms through the TLR9 pathway.

Pharm Biol 2018 Dec;56(1):580-593

a School of Traditional Chinese Materia Medica , Shenyang Pharmaceutical University , Shenyang , China.

Context: Ma Huang Tang (MHT) has been used to treat influenza, fever, bronchial asthma, etc. as a traditional Chinese medication. However, the anti-inflammation mechanism of MHT remains unclear. Read More

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https://www.tandfonline.com/doi/full/10.1080/13880209.2018.1
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http://dx.doi.org/10.1080/13880209.2018.1517184DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6237163PMC
December 2018
8 Reads

Phylogenetic analysis of Uncaria species based on internal transcribed spacer (ITS) region and ITS2 secondary structure.

Pharm Biol 2018 Dec;56(1):548-558

b School of Traditional Chinese Medicine , Guangdong Pharmaceutical University , Guangzhou , People's Republic of China.

Context: The plant genus Uncaria (Rubiaceae), also known as Gouteng, is the source of an important traditional Chinese medicine. Misidentification and adulteration of Gouteng affect the safety and efficacy of the medication. Phylogenetic relationships among the species of this genus are unknown. Read More

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http://dx.doi.org/10.1080/13880209.2018.1499780DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225500PMC
December 2018
1 Read
1.340 Impact Factor

Anti-inflammatory effects of shikonin in human periodontal ligament cells.

Pharm Biol 2018 Dec;56(1):415-421

a Tissue Repair and Regeneration Program , Institute of Health and Biomedical Innovation, Queensland University of Technology , Brisbane , Australia.

Context: Shikonin (SHI), an active component extracted from Radix Arnebiae, has been reported to possess anti-inflammatory properties in various cells. However, its effect on lipopolysaccharide (LPS)-stimulated human periodontal ligament cells (hPDLCs) is unknown.

Objective: To investigate the effects of SHI on the expression of inflammatory related cytokines in LPS-stimulated hPDLCs. Read More

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https://www.tandfonline.com/doi/full/10.1080/13880209.2018.1
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http://dx.doi.org/10.1080/13880209.2018.1506482DOI Listing
December 2018
14 Reads

Green synthesis of selenium nanoparticles with extract of hawthorn fruit induced HepG2 cells apoptosis.

Pharm Biol 2018 Dec;56(1):528-534

a School of Pharmaceutical Science , Shanxi Medical University , Taiyuan , PR China.

Context: Selenium nanoparticles (SeNPs) have attracted worldwide attention due to their unique properties and potential bioactivities. Considering that hawthorn is both a traditional medicine and a common edible food, hawthorn fruit extract (HE) was chosen as a reductant to prepare SeNPs.

Objective: SeNPs were synthesized by using an aqueous HE as a reductant and stabilizer. Read More

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https://www.tandfonline.com/doi/full/10.1080/13880209.2018.1
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http://dx.doi.org/10.1080/13880209.2018.1510974DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225412PMC
December 2018
8 Reads

Crataegus aronia enhances sperm parameters and preserves testicular architecture in both control and non-alcoholic fatty liver disease-induced rats.

Authors:
Mohammad Dallak

Pharm Biol 2018 Dec;56(1):535-547

a Department of Physiology , College of Medicine, King Khalid University , Abha , Saudi Arabia.

Context: Crataegus aronia (syn. Azarolus L.) (Rosaceae) is used in traditional medicine due to its hypolipidaemic and antioxidant properties. Read More

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https://www.tandfonline.com/doi/full/10.1080/13880209.2018.1
Publisher Site
http://dx.doi.org/10.1080/13880209.2018.1523934DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6211218PMC
December 2018
7 Reads

Safranal-promoted differentiation and survival of dopaminergic neurons in an animal model of Parkinson's disease.

Authors:
Yi Zhao Gangming Xi

Pharm Biol 2018 Dec;56(1):450-454

a Neurology Department of Xuhui Central Hospital , ShangHai , China.

Context: Safranal (SAF) is verified to have potential effects in promoting nerve growth.

Objectives: This study verifies the role of SAF in promoting dopaminergic neurons growth in vitro and in vivo.

Material And Methods: Rat neural stem cells (NSC) were treated with 1, 20, or 100 ng/mL of SAF, and the expression levels of tyrosine hydroxylase (TH) and dopamine transporter (DAT) were assayed by flow cytometry and real-time PCR and the secretion of dopamine (DA) was assayed by ELISA. Read More

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http://dx.doi.org/10.1080/13880209.2018.1501705DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6201804PMC
December 2018
8 Reads

Effects of psoralen on the pharmacokinetics of anastrozole in rats.

Pharm Biol 2018 Dec;56(1):433-439

a TCM Department of Breast , Longhua Hospital Affiliated to Shanghai University of TCM , Shanghai , China.

Context: Psoralen and anastrozole are always used together for breast cancer patients in Chinese clinics.

Objective: This study investigates the effects of psoralen on the pharmacokinetics of anastrozole in rats and its potential mechanism.

Materials And Methods: The pharmacokinetics of orally administered anastrozole (0. Read More

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http://dx.doi.org/10.1080/13880209.2018.1501584DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6201813PMC
December 2018
1 Read

Echinacea biotechnology: advances, commercialization and future considerations.

Pharm Biol 2018 Dec;56(1):485-494

a Ottawa-Carleton Institute of Biology , Ottawa , ON , Canada.

Context: Plants of the genus Echinacea (Asteraceae) are among the most popular herbal supplements on the market today. Recent studies indicate there are potential new applications and emerging markets for this natural health product (NHP).

Objective: This review aims to synthesize recent developments in Echinacea biotechnology and to identify promising applications for these advances in the industry. Read More

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https://www.tandfonline.com/doi/full/10.1080/13880209.2018.1
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http://dx.doi.org/10.1080/13880209.2018.1501583DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6179083PMC
December 2018
12 Reads

Dicranopteris linearis extract inhibits the proliferation of human breast cancer cell line (MDA-MB-231) via induction of S-phase arrest and apoptosis.

Pharm Biol 2018 Dec;56(1):422-432

a Halal Products Development, Halal Products Research Institute , Universiti Putra Malaysia (UPM) Serdang , Selangor , Malaysia.

Context: Dicranopteris linearis (Burm.f.) Underw. Read More

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https://www.tandfonline.com/doi/full/10.1080/13880209.2018.1
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http://dx.doi.org/10.1080/13880209.2018.1495748DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6179048PMC
December 2018
4 Reads

3,3'-Diindolylmethane enhances apoptosis in docetaxel-treated breast cancer cells by generation of reactive oxygen species.

Pharm Biol 2018 Dec;56(1):407-414

a Department of Surgery , Thomas Jefferson University , Philadelphia , PA , USA.

Context: A major problem in the treatment of cancer is the development of toxic side effects and resistance to chemotherapy. The use of plant compounds to overcome resistance and prevent toxicity is a potential strategy for treatment.

Objective: We evaluated whether 3,3'-diindolylmethane (DIM) enhanced the sensitivity of breast cancer cells to docetaxel (DOC). Read More

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http://dx.doi.org/10.1080/13880209.2018.1495747DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6179060PMC
December 2018
2 Reads

Synthesis, characterization and evaluation of transfection efficiency of dexamethasone conjugated poly(propyleneimine) nanocarriers for gene delivery#.

Pharm Biol 2018 Dec;56(1):519-527

e Targeted Drug Delivery Research Center, Institute of Pharmaceutical Technology , Mashhad University of Medical Sciences , Mashhad , Iran.

Context: Polypropylenimine (PPI), a cationic dendrimer with defined structure and positive surface charge, is a potent non-viral vector. Dexamethasone (Dexa) conveys to the nucleus through interaction with its intracellular receptor.

Objective: This study develops efficient and non-toxic gene carriers through conjugation of Dexa at various percentages (5, 10 and 20%) to the fourth and the fifth generation PPIs (PPIG4s and PPIG5s). Read More

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http://dx.doi.org/10.1080/13880209.2018.1517183DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6171438PMC
December 2018
1 Read
1.340 Impact Factor

Bioinformatics analysis to identify action targets in NCI-N87 gastric cancer cells exposed to quercetin.

Pharm Biol 2018 Dec;56(1):393-398

b Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine (TCM) Prevention and Treatment of Tumor , Nanjing University of Chinese Medicine , Nanjing , Jiangsu , China.

Context: Quercetin exerts antiproliferative effects on gastric cancer. However, its mechanisms of action on gastric cancer have not been comprehensively revealed.

Objective: We investigated the mechanisms of action of quercetin against gastric cancer cells. Read More

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http://dx.doi.org/10.1080/13880209.2018.1493610DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6171422PMC
December 2018
2 Reads

Enhanced production of tanshinone IIA in endophytic fungi Emericella foeniculicola by genome shuffling.

Pharm Biol 2018 Dec;56(1):357-362

a College of Life Sciences , Shaanxi Normal University, Chang'an Campus , Xi'an , Shaanxi , China.

Context: Tanshinone IIA, commercially produced from Salvia miltiorrhiza Bunge (C.Y.Wu) (Labiatae), has various biological benefits. Read More

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https://www.tandfonline.com/doi/full/10.1080/13880209.2018.1
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http://dx.doi.org/10.1080/13880209.2018.1481108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6171462PMC
December 2018
12 Reads

Adaptation of a microbead assay for the easy evaluation of traditional anti-sickling medicines: application to DREPANOSTAT and FACA.

Pharm Biol 2018 Dec;56(1):385-392

a Pharma-Dev, UMR 152 , Université de Toulouse, IRD, UPS , Toulouse , France.

Context: Sickle cell disease is a common inherited blood disorder affecting millions of people worldwide. Due to lack of progress in drug discovery for a suitable treatment, sufferers often turn to traditional medicines that take advantage of the plant extracts activity used by traditional healers.

Objective: This study optimizes an anti-sickling screening test to identify preparations capable of reverting sickle cells back to the morphology of normal red blood cells. Read More

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http://dx.doi.org/10.1080/13880209.2018.1501585DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161593PMC
December 2018
12 Reads

Some pharmacokinetic parameters of salvianolic acid A following single-dose oral administration to rats.

Pharm Biol 2018 Dec;56(1):399-406

a Department of Pharmacy , The Affiliated Hospital of Qingdao University , Qingdao , People's Republic of China.

Context: Salvianolic acid A (Sal A) is a hydrophilic bioactive compound isolated from Salvia miltiorrhiza Bunge (Lamiaceae). It exerts beneficial effects after oral administration on diabetic complications.

Objective: To systematically study the absorption, distribution and excretion of Sal A after single-dose oral administration. Read More

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http://dx.doi.org/10.1080/13880209.2018.1491998DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6130628PMC
December 2018
17 Reads

Mechanisms of butylidenephthalide for twitch facilitation in electrically stimulated mouse vas deferens.

Pharm Biol 2018 Dec;56(1):378-384

d Department of Pharmacology, School of Medicine, College of Medicine , Taipei Medical University , Taipei , Taiwan.

Context: The rhizome of Ligusticum chuaxiong Hort. (Umbelliferae) has been used by Chinese for several thousand years. Its main constituent, butylidenephthalide (Bdph), was proved to be active in inhibiting rat uterine contractions induced by prostaglandin F and was reported to be a nonspecific antispamodic and a blocker of voltage-dependent Ca channels (VDCCs). Read More

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http://dx.doi.org/10.1080/13880209.2018.1495749DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6130712PMC
December 2018
2 Reads

In vitro inhibitory effects of Friedelin on human liver cytochrome P450 enzymes.

Pharm Biol 2018 Dec;56(1):363-367

a Department of Public Health , Yidu Central Hospital of Weifang , Weifang , Shandong , China.

Context: Friedelin is a triterpenoid with several biological activities. However, the affects of Friedelin on the activity of human liver cytochrome P450 (CYP) enzymes remains unclear.

Objective: This study investigates the inhibitory effects of Friedelin on the major human liver CYP isoforms (CYP3A4, 1A2, 2A6, 2E1, 2D6, 2C9, 2C19 and 2C8). Read More

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http://dx.doi.org/10.1080/13880209.2018.1491999DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6130513PMC
December 2018
1 Read

Assessing product adulteration of Eurycoma longifolia (Tongkat Ali) herbal medicinal product using DNA barcoding and HPLC analysis.

Pharm Biol 2018 Dec;56(1):368-377

a Department of Biotechnology & Medical Engineering, Faculty of Biosciences and Medical Engineering , UTM Skudai , Johor , Malaysia.

Context: Eurycoma longifolia Jack (Simaroubaceae) commonly known as Tongkat Ali is one of the most important plants in Malaysia. The plant extracts (particularly roots) are widely used for the treatment of cough and fever besides having antimalarial, antidiabetic, anticancer and aphrodisiac activities.

Objectives: This study assesses the extent of adulteration of E. Read More

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http://dx.doi.org/10.1080/13880209.2018.1479869DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6130542PMC
December 2018
22 Reads

Dihydromyricetin improves vascular hyporesponsiveness in experimental sepsis via attenuating the over-excited MaxiK and K channels.

Pharm Biol 2018 Dec;56(1):344-350

a Department of ICU , Shengli Oilfield Central Hospital , Dongying , China.

Context: Dihydromyricetin (DMY) has oxidation resistance, anti-inflammatory and free radical scavenging capabilities. The preventive effects of DMY for vascular hyporeactivity remain unclear.

Objective: This study investigates the preventive effects of DMY in vascular hyporeactivity. Read More

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http://dx.doi.org/10.1080/13880209.2018.1478430DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6130638PMC
December 2018
4 Reads
1.340 Impact Factor

Influence of andrographolide on the pharmacokinetics of warfarin in rats.

Pharm Biol 2018 Dec;56(1):351-356

b Department of Nursing , Yidu Central Hospital of Weifang , Shandong , China.

Context: Andrographolide and warfarin are often used together in clinics in China. However, the herb-drug interaction between andrographolide and warfarin is still unknown.

Objective: This study investigates the herb-drug interaction between andrographolide and warfarin in vivo and in vitro. Read More

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http://dx.doi.org/10.1080/13880209.2018.1478431DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6130436PMC
December 2018
7 Reads

Effects of garlic polysaccharide on alcoholic liver fibrosis and intestinal microflora in mice.

Pharm Biol 2018 Dec;56(1):325-332

b Department of Biotechonolgy , Dalian Medical University , Dalian , PR China.

Context: Alcoholic liver fibrosis (ALF) is treatable and reversible consequence of liver disease. Intestinal microflora plays an important role in the progression of liver disease. Garlic (Allium sativum L. Read More

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http://dx.doi.org/10.1080/13880209.2018.1479868DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6130653PMC
December 2018
7 Reads

Effect of citral on mouse hepatic cytochrome P450 enzymes.

Pharm Biol 2018 Dec;56(1):337-343

a School of Laboratory Medicine , Chengdu Medical College , Chengdu , Sichuan , PR China.

Context: Citral is used as a potential natural treatment for various infectious diseases.

Objective: To examine the effect of citral on the mRNA expression and activities of cytochrome P450 (CYP450) enzymes and establish the relationship between citral-induced liver injury and oxidative stress.

Materials And Methods: ICR mice were randomly divided into citral (20, 200, and 2000 mg/kglow), Tween-80, and control groups (0. Read More

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http://dx.doi.org/10.1080/13880209.2018.1470191DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6130695PMC
December 2018
13 Reads

Antitubercular evaluation of root extract and isolated phytochemicals from Lophira lanceolata against two resistant strains of Mycobacterium tuberculosis.

Pharm Biol 2018 Dec;56(1):318-324

d Faculty of Chemistry , Philipps-Universität Marburg , Marburg , Germany.

Context: The roots of Lophira lanceolata Van Tiegh. Ex Keay (Ochnaceae) have numerous medicinal values in the Central African region. Even though the MeOH extract of the roots has shown antimycobacterial activities, the constituents responsible for this inhibitory activity remain unknown. Read More

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https://www.tandfonline.com/doi/full/10.1080/13880209.2018.1
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http://dx.doi.org/10.1080/13880209.2018.1476559DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6130701PMC
December 2018
5 Reads

Effects of Ginkgo leaf tablets on the pharmacokinetics of losartan and its metabolite EXP3174 in rats and its mechanism.

Pharm Biol 2018 Dec;56(1):333-336

a Department of Neurology , Caoxian People's Hospital , Heze , Shandong Province , China.

Context: Ginkgo leaf tablets (GLTs) and losartan are often simultaneously used for the treatment of hypertension in Chinese clinics. However, the herb-drug interaction between GLT and losartan is still unknown.

Objective: This study investigates the effects of GLT on the pharmacokinetics of losartan and its metabolite EXP3174 in rats and its potential mechanism. Read More

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http://dx.doi.org/10.1080/13880209.2018.1481107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6130633PMC
December 2018
20 Reads

Quercetin promotes gastrointestinal motility and mucin secretion in loperamide-induced constipation of SD rats through regulation of the mAChRs downstream signal.

Pharm Biol 2018 Dec;56(1):309-317

a College of Natural Resources & Life Science/Life and Industry Convergence Research Institute , Pusan National University , Miryang , Korea.

Context: Quercetin (QCT) has been known as a potential therapeutic strategy for gastrointestinal diseases because it contributes to the stabilization of mast cells, the prevention of histamine release and modulation of CaCC chloride channel.

Objective: We investigated the laxative effect and action mechanism of QCT in Lop-induced constipation model.

Materials And Methods: Constipation of SD rats was induced by subcutaneous injection of loperamide (Lop) (4 mg/kg weight) in 0. Read More

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http://dx.doi.org/10.1080/13880209.2018.1474932DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6130520PMC
December 2018
14 Reads
1.340 Impact Factor

Galangin, a dietary flavonoid, ameliorates hyperglycaemia and lipid abnormalities in rats with streptozotocin-induced hyperglycaemia.

Pharm Biol 2018 Dec;56(1):302-308

b Department of Community Health Sciences, College of Applied Medical Sciences , King Saud University , Riyadh , Saudi Arabia.

Context: Galangin, a natural flavonoid, is found in honey and Alpinia officinarum Hance (Zingiberaceae). Galangin has antiviral, antimicrobial, antidiabetic and anticancer properties, without side effects. The effects of galangin on hyperglycaemia and lipid abnormalities are not known. Read More

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http://dx.doi.org/10.1080/13880209.2018.1474931DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6130595PMC
December 2018
2 Reads

Effects and possible mechanisms of Alpinia officinarum ethanol extract on indomethacin-induced gastric injury in rats.

Pharm Biol 2018 Dec;56(1):294-301

a Hainan Provincial Key Laboratory of R&D of Tropical Herbs , Hainan Medical University , Haikou , China.

Context: Alpinia officinarum Hance (Zingiberoside) has a long history in treating gastrointestinal diseases, but its mechanisms of action are not yet known.

Objective: To investigate the effects and underlying mechanisms of the ethanol extract of A. officinarum rhizomes in an indomethacin-induced gastric injury rat model. Read More

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http://dx.doi.org/10.1080/13880209.2018.1450426DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6130516PMC
December 2018
16 Reads

The suppressive effect of the three-herb extract mixture on vascular and liver inflammation in atherogenic diet with high fructose-fed mice.

Pharm Biol 2018 Dec;56(1):32-42

a Department of Oriental Medicine Biotechnology , College of Life Sciences, Kyung Hee University , Yongin , Republic of Korea.

Context: Cynanchum wilfordii (Maximowicz) Hemsley (Apocynaceae), Arctium lappa L. var. rubescens Frivald (Asteraceae) and Dioscorea opposite Thunb (Dioscoreaceae) root extracts have been widely used as an alternative for intervening obesity. Read More

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http://dx.doi.org/10.1080/13880209.2017.1412468DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6130671PMC
December 2018
21 Reads

Lipopolysaccharide from Rhodobacter sphaeroides (TLR4 antagonist) attenuates hypersensitivity and modulates nociceptive factors.

Pharm Biol 2018 Dec;56(1):275-286

a Department of Pain Pharmacology , Institute of Pharmacology, Polish Academy of Sciences , Krakow , Poland.

Context: Accumulating evidence has demonstrated that Toll-like receptors (TLRs), especially TLR4 localized on microglia/macrophages, may play a significant role in nociception.

Objective: We examine the role of TLR4 in a neuropathic pain model. Using behavioural/biochemical methods, we examined the influence of TLR4 antagonist on levels of hypersensitivity and nociceptive factors whose contribution to neuropathy development has been confirmed. Read More

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http://dx.doi.org/10.1080/13880209.2018.1457061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6130482PMC
December 2018
10 Reads

Screening of in vitro antimicrobial activity of plants used in traditional Indonesian medicine.

Pharm Biol 2018 Dec;56(1):287-293

a Department of Crop Sciences and Agroforestry, Faculty of Tropical AgriSciences , Czech University of Life Sciences Prague , Prague , Czech Republic.

Context: In many regions of Indonesia, there are numerous traditional herbal preparations for treatment of infectious diseases. However, their antimicrobial potential has been poorly studied by modern laboratory methods.

Objective: This study investigates in vitro antimicrobial activity of 49 ethanol extracts from 37 plant species used in Indonesian traditional medicine for treatment against Candida albicans, Enterococcus faecalis, Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus. Read More

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http://dx.doi.org/10.1080/13880209.2018.1462834DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6130619PMC
December 2018
5 Reads

Effects of diclofenac on the pharmacokinetics of celastrol in rats and its transport.

Pharm Biol 2018 Dec;56(1):269-274

a Department of Anesthesiology , Shengli Oilfield Central Hospital , Dongying , P. R. China.

Context: Diclofenac and celastrol are always used together for the treatment of rheumatoid arthritis; the herb-drug interaction potential between diclofenac and celastrol is still unknown.

Objective: This study investigates the effects of diclofenac on the pharmacokinetics of celastrol in rats.

Materials And Methods: Twelve male Sprague-Dawley rats were divided into two groups and received celastrol (1 mg/kg) or both celastrol (1 mg/kg) and diclofenac (10 mg/kg) by oral gavage, and blood samples were collected via the oculi chorioideae vein and determined using the LC-MS method developed in this study. Read More

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http://dx.doi.org/10.1080/13880209.2018.1459740DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6130456PMC
December 2018
3 Reads

Brazilian medicinal plants with corroborated anti-inflammatory activities: a review.

Pharm Biol 2018 Dec;56(1):253-268

a Department of Pharmaceutical Sciences, School of Pharmaceutical Sciences of Ribeirão Preto , University of São Paulo , Ribeirão Preto , Brazil.

Context: Inflammatory disorders are common in modern life, and medicinal plants provide an interesting source for new compounds bearing anti-inflammatory properties. In this regard, Brazilian medicinal plants are considered to be a promising supply of such compounds due to their great biodiversity.

Objectives: To undertake a review on Brazilian medicinal plants with corroborated anti-inflammatory activities by selecting data from the literature reporting the efficacy of plants used in folk medicine as anti-inflammatory, including the mechanisms of action of their extracts and isolated compounds. Read More

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http://dx.doi.org/10.1080/13880209.2018.1454480DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6130656PMC
December 2018
4 Reads

Zanthoxylum alatum abrogates lipopolysaccharide-induced depression-like behaviours in mice by modulating neuroinflammation and monoamine neurotransmitters in the hippocampus.

Pharm Biol 2018 Dec;56(1):245-252

f Department of Psychiatry, Molecular Biology Research Building (MBRB) , University of Illinois , Chicago , IL , USA.

Context: Depression is an inflammatory, commonly occurring and lethal psychiatric disorder having high lifetime prevalence. Zanthoxylum alatum Roxb. (Rutaceae), commonly called Timur, has high medicinal value and is used ethnomedicinally for the treatment of various diseases. Read More

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http://dx.doi.org/10.1080/13880209.2017.1391298DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6130615PMC
December 2018
45 Reads

Isolation and identification of three new chromones from the leaves of Pimenta dioica with cytotoxic, oestrogenic and anti-oestrogenic effects.

Pharm Biol 2018 Dec;56(1):235-244

f Department of Pharmacy Practice , PAHO/WHO Collaborating Centre for Traditional Medicine, College of Pharmacy, University of Illinois at Chicago , Chicago , IL , USA.

Context: Pimenta dioica (L.) Merr. (Myrtaceae) is used in Costa Rican traditional medicine for women's health. Read More

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http://dx.doi.org/10.1080/13880209.2018.1448873DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6130578PMC
December 2018
6 Reads