2,147 results match your criteria Pharmaceutical Biology [Journal]


Chronic unpredictable mild stress induced depression-like behaviours and glutamate-glutamine cycling dysfunctions in both blood and brain of mice.

Pharm Biol 2019 Dec;57(1):280-286

a School of Pharmaceutical Sciences , Southern Medical University , Guangzhou , PR China.

Context: Currently, there is no cure or early preclinical diagnostic assay available for depression. Recently, depression has been observed in association with metabolic abnormalities of the glutamate (Glu)-glutamine (Gln) cycling, which is regulated by Glu, Gln and γ-aminobutyric acid (GABA) amino acids.

Objective: The purpose of this study is to determine the changes of Glu, Gln and GABA in blood and brain of chronic unpredictable mild stress (CUMS) induced mice and to clarify the depression biomarkers in the Glu-Gln cycling. Read More

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http://dx.doi.org/10.1080/13880209.2019.1598445DOI Listing
December 2019

Coptidis Rhizoma: a comprehensive review of its traditional uses, botany, phytochemistry, pharmacology and toxicology.

Pharm Biol 2019 Dec;57(1):193-225

b Ya'an Xun Kang Pharmaceutical Co., Ltd , Ya'an , China.

Context: Coptidis rhizome (CR), also known as Huanglian in Chinese, is the rhizome of Coptis chinensis Franch., C. deltoidea C. Read More

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http://dx.doi.org/10.1080/13880209.2019.1577466DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461078PMC
December 2019
1 Read

Synergistic effects of deuterium depleted water and Mentha longifolia L. essential oils on sepsis-induced liver injuries through regulation of cyclooxygenase-2.

Pharm Biol 2019 Dec;57(1):125-132

a Department of Biochemistry, Faculty of Sciences , Payame-e-Noor University , Tehran , Iran.

Context: Mentha longifolia L. (Lamiaceae), a traditional medicinal herb, has been highly valued for exhibiting antimicrobial, antioxidant and antispasmodic properties.

Objective: For the first time, the synergetic anti-inflammatory effects of deuterium depleted water (DDW) and M. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461093PMC
December 2019
2 Reads

Evaluation of the neuroprotective and antioxidant effects of Dorema aucheri extract on cerebral ischaemia-reperfusion injury in rats.

Pharm Biol 2019 Dec;57(1):255-262

b Department of Physiology and Biophysics School of Medicine , Baqiyatallah University of Medical Sciences , Tehran , Iran.

Context: The hydroalcoholic extract of Dorema aucheri Bilhar (Umbelliferae) (DA) leaves, a medicinal plant, has powerful antioxidant properties.

Objective: This study evaluates the neuroprotective effects of pre-treatment with DA leaves extract against cerebral ischaemia-induced brain injury through alteration of the antioxidant capacity.

Materials And Methods: The study was conducted in three groups of Wistar rats (N = 47) as follows; sham, control ischaemic and pre-treated ischaemic groups. Read More

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https://www.tandfonline.com/doi/full/10.1080/13880209.2019.1
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http://dx.doi.org/10.1080/13880209.2019.1597132DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461074PMC
December 2019
5 Reads

Curcumin ameliorates gestational diabetes in mice partly through activating AMPK.

Pharm Biol 2019 Dec;57(1):250-254

b Department of Obstetrics and Gynecology , The Second Hospital of Jilin University , Changchun , China.

Context: In vitro and in vivo research has shown that curcumin can alleviate diabetes and the relevant complications.

Objective: To investigate the effect of curcumin on gestational diabetes (GD).

Materials And Methods: C57 BL/KsJ(db/+) mice and C57 BL/KsJ mice (10-12 weeks old) were divided into four groups (n = 15): normal pregnancy (C57 BL/KsJ), GD (C57 BL/KsJ), GD plus low dose curcumin (50 mg/kg, orally gavage every day) and GD plus high dose curcumin (100 mg/kg, orally gavage every day). Read More

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http://dx.doi.org/10.1080/13880209.2019.1594311DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461094PMC
December 2019
1 Read

Differential effects of genistein and 8-prenylgenistein on reproductive tissues in immature female mice.

Pharm Biol 2019 Dec;57(1):226-230

c Spine Disease Research Institute , Longhua Hospital, Affiliated to Shanghai University of Traditional Chinese Medicine , Shanghai , P. R. China.

Context: We identified an active prenylated derivative of genistein, 8-prenylgenistein (8PG) from Erythrina variegata L. (Leguminosae) and found that 8PG increased osteoprotective effects of genistein in oestrogen-deficient mice.

Objective: This study investigated and compared the oestrogenic effects of genistein and 8PG on uterus and vagina of immature mice. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461073PMC
December 2019
2 Reads

Regulation of P-glycoprotein by Bajijiasu in vitro and in vivo by activating the Nrf2-mediated signalling pathway.

Pharm Biol 2019 Dec;57(1):184-192

b Department of Obstetrics and Gynecology, Guangdong Women and Children Hospital , Guangzhou , China.

Context: Bajijiasu (BJJS), a main bioactive compound from Morinda officinalis F.C. How. Read More

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http://dx.doi.org/10.1080/13880209.2019.1582679DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450468PMC
December 2019

Allicin disrupts cardiac Cav1.2 channels via trafficking.

Pharm Biol 2019 Dec;57(1):245-249

a Arrhythmia Unit, Department of Cardiology , The First Affiliated Hospital of Xi'an Jiaotong University , Xi'an, China.

Context: Allicin is a potential antiarrhythmic agent. The antiarrhythmic properties of allicin rely on its blockade of various cardiac ion channels. The l-type calcium (Cav1. Read More

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http://dx.doi.org/10.1080/13880209.2019.1577469DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450490PMC
December 2019

Osthole inhibits proliferation and induces apoptosis in BV-2 microglia cells in kainic acid-induced epilepsy via modulating PI3K/AKt/mTOR signalling way.

Pharm Biol 2019 Dec;57(1):238-244

a Department of Medical College, Dalian University , Liaoning , China.

Context: Osthole is a natural coumarin compound most frequently extracted from plants of the Apiaceae family such as Cnidium monnieri (L.) Cusson, Angelica pubescens Maxin.f. Read More

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http://dx.doi.org/10.1080/13880209.2019.1588905DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442221PMC
December 2019

Effects of Phyllanthus amarus PHYLLPRO leaves on hangover symptoms: a randomized, double-blind, placebo-controlled crossover study.

Pharm Biol 2019 Dec;57(1):145-153

d Centre for Sports and Exercise Sciences , Exercise Science, University of Malaya , Kuala Lumpur , Malaysia.

Context: Phyllanthus amarus Schumach. and Thonn. (Euphorbiaceae) is traditionally known to improve general liver health. Read More

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https://www.tandfonline.com/doi/full/10.1080/13880209.2019.1
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http://dx.doi.org/10.1080/13880209.2019.1585460DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442116PMC
December 2019
2 Reads
1.337 Impact Factor

β-Sitosterol modulates macrophage polarization and attenuates rheumatoid inflammation in mice.

Pharm Biol 2019 Dec;57(1):161-168

a Department of Rheumatism , Suzhou Hospital Affiliated to Nanjing University of Chinese Medicine , Suzhou , PR China.

Context: β-Sitosterol (BS), the primary constituent of plants and vegetables, exhibits multiple biological effects.

Objective: This study explores its effect of immune-regulation on macrophages and its potential for rheumatoid arthritis (RA) therapy.

Materials And Methods: In vitro, bone marrow-derived macrophages (BMDMs) were treated with 5, 25 and 50 μM BS in the M1 or M2 polarization conditions. Read More

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http://dx.doi.org/10.1080/13880209.2019.1577461DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442231PMC
December 2019
1 Read
1.337 Impact Factor

Chang-wei-qing, a Chinese herbal formula, ameliorates colitis-associated tumour development via inhibiting NF-κB and STAT3 signalling pathway.

Pharm Biol 2019 Dec;57(1):231-237

c Department of Ultrasound , Shanghai University of Traditional Chinese Medicine Affiliated PUTUO Hospital , Shanghai , China.

Context: Chang-wei-qing (CWQ) is a Chinese herbal recipe with clinical efficacy. However, the molecular mechanism underlying its recognized therapeutic benefits against colorectal cancer is still elusive.

Objective: To investigate the potential beneficial effects of CWQ in drug-induced colitis-associated cancer (CAC) model and its mechanistic involvements in this disease. Read More

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http://dx.doi.org/10.1080/13880209.2019.1577465DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442084PMC
December 2019

Astragaloside IV alleviates heart failure by promoting angiogenesis through the JAK-STAT3 pathway.

Pharm Biol 2019 Dec;57(1):48-54

d Fourth Unit of Department of Cardiology , First Affiliated Hospital of Heilongjiang University of Chinese Medicine , Harbin , China.

Context: Heart failure (HF) is one of the most serious diseases worldwide. Astragaloside IV (ASI) is widely used for the treatment of cardiovascular disease in China.

Objective: To evaluate the protective effect of ASI on the HF in a Sprague-Dawley rat model of left coronary artery ligation, and investigate the angiogenesis-related mechanisms. Read More

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http://dx.doi.org/10.1080/13880209.2019.1569697DOI Listing
December 2019
1 Read

Ursolic acid inhibits epithelial-mesenchymal transition in vitro and in vivo.

Pharm Biol 2019 Dec;57(1):169-175

d Department of Urology , Renmin Hospital of Wuhan University , Wuhan , China.

Context: Ursolic acid (UA; 3β-hydroxy-urs-12-en-28-oic acid), one of the pentacyclic triterpenoids found in various plants and herbs, possesses some beneficial effects under pathological conditions, including combating hepatic fibrosis.

Objective: This study investigates the effects of UA on renal tubulointerstitial fibrosis in vivo and in vitro.

Materials And Methods: In vivo, 24 male C57BL6 mice were divided into four groups. Read More

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http://dx.doi.org/10.1080/13880209.2019.1577464DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442106PMC
December 2019
1.337 Impact Factor

Chemical composition, anti-toxoplasma, cytotoxicity, antioxidant, and anti-inflammatory potentials of Cola gigantea seed oil.

Pharm Biol 2019 Dec;57(1):154-160

c Department of Horticulture , Cape Peninsula University of Technology , South Africa.

Context: Cola gigantea A. Chev. (Sterculiaceae) is an important medicinal tropical flora. Read More

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http://dx.doi.org/10.1080/13880209.2019.1577468DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442224PMC
December 2019
1 Read

Amaranth (Amaranthus cruentus L.) and canola (Brassica napus L.) oil impact on the oxidative metabolism of neutrophils in the obese patients.

Pharm Biol 2019 Dec;57(1):140-144

a Department of Pathophysiology , Poznań University of Medical Sciences , Poznań , Poland.

Context: Amaranth and canola oils have been used traditionally. Amaranth has been identified as being of interest because of its outstanding nutritive value. Amaranth oil is a rich source of highly unsaturated fats and so could be a valuable dietary alternative for individuals affected with obesity. Read More

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http://dx.doi.org/10.1080/13880209.2019.1569696DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442228PMC
December 2019

Effects of steroidal saponins extract from Ophiopogon japonicus root ameliorates doxorubicin-induced chronic heart failure by inhibiting oxidative stress and inflammatory response.

Pharm Biol 2019 Dec;57(1):176-183

d Department of Cardiology , The Second Affiliated Hospital of Xi'an JiaoTong University , Xian , China.

Context: Ophiopogonis Radix, the root of Ophiopogon japonicus (Thunb.) Ker-Gawl (Liliaceae), is a Traditional Chinese Medicine, which has been investigated to possess effective treatment of cardiovascular diseases.

Objective: This study evaluates the cardioprotective effects of steroidal saponins extract from Ophiopogon japonicus (SOJ) root against doxorubicin-induced chronic heart failure (CHF) through the amelioration of oxidative stress and inflammation. Read More

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http://dx.doi.org/10.1080/13880209.2019.1577467DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419681PMC
December 2019
1 Read

The clickable activity-based probe of anti-apoptotic calenduloside E.

Pharm Biol 2019 Dec;57(1):133-139

a Beijing Key Laboratory of Innovative Drug Discovery of Traditional Chinese Medicine (Natural Medicine) and Translational Medicine , Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College , Beijing , China.

Context: Calenduloside E (CE), one of the primary natural products found in Aralia elata (Miq.) Seem. (Araliaceae), possesses prominent anti-apoptotic potential. Read More

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http://dx.doi.org/10.1080/13880209.2018.1557699DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407588PMC
December 2019

Molecular mechanistic insight into the anti-hyperuricemic effect of Eucommia ulmoides in mice and rats.

Pharm Biol 2019 Dec;57(1):112-119

b School of Basic Medicine, Jiangxi University of Traditional Chinese Medicine , Nanchang , China.

Context: Eucommia ulmoides Oliver (Eucommiaceae) has various medicinal properties. Our previous studies revealed that Eucommia ulmoides has a protective effect on hyperuricaemia.

Objective: This study investigates the effect of Eucommia ulmoides cortex ethanol extract (EU) on hyperuricaemia and explores the underlying mechanism in Kunming mice and Sprague-Dawley rats. Read More

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http://dx.doi.org/10.1080/13880209.2019.1568510DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419643PMC
December 2019
2 Reads

Larvicidal and ovicidal activities of Artocarpus blancoi extracts against Aedes aegypti.

Pharm Biol 2019 Dec;57(1):120-124

c Faculty of Pharmacy , Meijo University , Nagoya City , Japan.

Context: Dengue control may be done by targeting its vector. In this study, we used Artocarpus blancoi (Elm.) Merr. Read More

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http://dx.doi.org/10.1080/13880209.2018.1561727DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6383622PMC
December 2019
1 Read

Hepatoprotective effects of Cassia semen ethanol extract on non-alcoholic fatty liver disease in experimental rat.

Pharm Biol 2019 Dec;57(1):98-104

a Department of Anesthesiology , Qilu Hospital of Shandong University , Shandong , Jinan , People's Republic of China.

Context: Cassia semen (Cs), a seed of Cassia obtusifolia L. (Leguminosae), is a popular functional beverage. Previous studies reported that Cs displayed antioxidant, antifungal and strong liver protective effects. Read More

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http://dx.doi.org/10.1080/13880209.2019.1568509DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374930PMC
December 2019
1 Read

Eclipta prostrata promotes the induction of anagen, sustains the anagen phase through regulation of FGF-7 and FGF-5.

Pharm Biol 2019 Dec;57(1):105-111

a Division of Applied Medicine, School of Korean Medicine , Pusan National University , Yangsan-si , Republic of Korea.

Context: Eclipta prostrata L. (Asteraceae) (EP) has been widely used for the treatment of skin disease in Asian traditional medicine.

Objective: This study investigates the potency of EP in promoting hair growth in vivo and in vitro. Read More

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http://dx.doi.org/10.1080/13880209.2018.1561729DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374973PMC
December 2019
1 Read

Inhibitory effects of fucoidan on NMDA receptors and l-type Ca channels regulating the Ca responses in rat neurons.

Pharm Biol 2019 Dec;57(1):1-7

b Photon Medical Research Center , Hamamatsu University School of Medicine , Hamamatsu , Japan.

Context: Fucoidan, a sulphated polysaccharide extracted from brown algae [Fucus vesiculosus Linn. (Fucaceae)], has multiple biological activities.

Objective: The effects of fucoidan on Ca responses of rat neurons and its probable mechanisms with focus on glutamate receptors were examined. Read More

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http://dx.doi.org/10.1080/13880209.2018.1548626DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374951PMC
December 2019
1 Read

Distributive differences of P2Xs between the forelimb and hind limb of adjuvant arthritis rats and intervention by Notopterygh rhizoma et radix.

Pharm Biol 2019 Dec;57(1):82-89

a College of Pharmacy , Fujian University of Traditional Chinese Medicine , Fuzhou , PR China.

Context: Notopterygium incisum Ting ex H. T. Chang (Umbelliferae) (NI) specializes in treatment of upper limb rheumatoid arthritis (RA), but the exact mechanism is unclear. Read More

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http://dx.doi.org/10.1080/13880209.2018.1561730DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366419PMC
December 2019
3 Reads

Neuronal protective effect of Songling Xuemaikang capsules alone and in combination with carbamazepine on epilepsy in kainic acid-kindled rats.

Pharm Biol 2019 Dec;57(1):22-28

a Department of Pharmacy , Lanzhou University Second Hospital , Lanzhou , China.

Context: Epilepsy is a common life-threatening neurological disorder that is often drug-resistant and associated with cognitive impairment. The traditional Chinese patent medicine Songling Xuemaikang capsules (SXC) is clinically used for epilepsy therapy and alleviation of cognitive impairment.

Objective: This study investigates the neuronal protective effect of SXC combined with carbamazepine (CBZ) on epilepsy and cognitive impairment in kainic acid-kindled SD rats. Read More

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http://dx.doi.org/10.1080/13880209.2018.1563619DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366425PMC
December 2019
2 Reads

Effects of Lespedeza Cuneata aqueous extract on testosterone-induced prostatic hyperplasia.

Pharm Biol 2019 Dec;57(1):90-98

b Department of Oriental Medicine Biotechnology , Kyung Hee University , Yongin , Republic of Korea.

Context: Lespedeza cuneata G. Don (Fabaceae), has been used as a traditional treatment of various diseases. There is a report L. Read More

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http://dx.doi.org/10.1080/13880209.2018.1564929DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366415PMC
December 2019
3 Reads

Vitexin as an active ingredient in passion flower with potential as an agent for nicotine cessation: vitexin antagonism of the expression of nicotine locomotor sensitization in rats.

Pharm Biol 2019 Dec;57(1):8-12

a Department of Pharmaceutical Sciences , Campbell University College of Pharmacy & Health Sciences , Buies Creek , NC , USA.

Context: Nicotine, a bioactive component of tobacco, is highly addictive. Numerous therapies have been developed for smoking cessation, and all have met with limited success. Our laboratory has previously shown that an extract of Passiflora incarnata Linn. Read More

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http://dx.doi.org/10.1080/13880209.2018.1561725DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366407PMC
December 2019
1 Read

GABA and l-theanine mixture decreases sleep latency and improves NREM sleep.

Pharm Biol 2019 Dec;57(1):65-73

d Department of Public Health Sciences , Graduate School , Seoul , Republic of Korea.

Context: γ-Aminobutyric acid (GABA) is the main inhibitory neurotransmitter and it is well established that activation of GABA receptors favours sleep. l-Theanine, a naturally occurring amino acid first discovered in green tea, is a well-known anti-anxiety supplement with proven relaxation benefits.

Objective: This study investigated the potential synergistic sleep enhancement effect of GABA/l-theanine mixture. Read More

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https://www.tandfonline.com/doi/full/10.1080/13880209.2018.1
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http://dx.doi.org/10.1080/13880209.2018.1557698DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366437PMC
December 2019
13 Reads

Anti-inflammatory and anti-osteoarthritis effect of Mollugo pentaphylla extract.

Pharm Biol 2019 Dec;57(1):74-81

a Herbal Medicine Research Division , Korea Institute of Oriental Medicine , Daejeon , South Korea.

Context: Mollugo pentaphylla L. (Molluginaceae) extract (MPE) has been reported to have anti-inflammatory effect on MSU-induced gouty arthritis in a mouse model.

Objective: This study examined the anti-inflammatory activities of an MPE in vitro and anti-osteoarthritis effects on monosodium iodoacetate (MIA)-induced osteoarthritis (OA) in vivo. Read More

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http://dx.doi.org/10.1080/13880209.2018.1557700DOI Listing
December 2019
2 Reads

Syzygium aromaticum aqueous extract inhibits human neutrophils myeloperoxidase and protects mice from LPS-induced lung inflammation.

Pharm Biol 2019 Dec;57(1):56-64

a Faculty of Sciences of Gabes , University of Gabes , Gabes , Tunisia.

Context: Syzygium aromaticum (L.) Merr. & Perry (Myrtaceae), commonly known as clove, originally found in the Muluku Islands in East Indonesia, is widely used as a spice and has numerous medicinal properties. Read More

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http://dx.doi.org/10.1080/13880209.2018.1557697DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366422PMC
December 2019

Crataegus Aronia protects and reverses vascular inflammation in a high fat diet rat model by an antioxidant mechanism and modulating serum levels of oxidized low-density lipoprotein.

Pharm Biol 2019 Dec;57(1):38-48

e Department of Biology College of Science, College of Medicine, King Khalid University (KKU), Abha, Saudi Arabia.

Context: Crataegus aronia (Willd.) Bosc (Rosaceae) (syn. Azarolus L) is traditionally used to treat cardiovascular disorders. Read More

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https://www.tandfonline.com/doi/full/10.1080/13880209.2018.1
Publisher Site
http://dx.doi.org/10.1080/13880209.2018.1564930DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366417PMC
December 2019
9 Reads

Analysis of the protective effects of γ-aminobutyric acid during fluoride-induced hypothyroidism in male Kunming mice.

Pharm Biol 2019 Dec;57(1):29-37

a Key Laborotory Experimental Marine Biology, Institute of Oceanology , Chinese Academy of Sciences , Qingdao , China.

Context: Compounds to treat hypothyroidism in the absence of cardiac side effects are urgently required. In this regard, γ-aminobutyric acid (GABA) has gained interest due to its anti-anxiolytic, antihypertensive and antioxidant properties, and reported benefits to the thyroid system.

Objective: We investigated the ability of GABA to ameliorate fluoride-induced thyroid injury in mice, and investigated the mechanism(s) associated with GABA-induced protection. Read More

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http://dx.doi.org/10.1080/13880209.2018.1563621DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346718PMC
December 2019
3 Reads

Resveratrol mitigates the oxidative stress mediated by hypoxic-ischemic brain injury in neonatal rats via Nrf2/HO-1 pathway.

Pharm Biol 2018 Dec;56(1):440-449

a Department of Neurology , Shengjing Hospital Affiliated Hospital of China Medical University , Shenyang, Liaoning , China.

Context: Hypoxic-ischemic encephalopathy (HIE) has a high morbidity and mortality rate. Resveratrol possesses numerous biological properties including antioxidant, anti-inflammatory and neuroprotective activities.

Objective: The current experiment investigates the neuroprotective efficacy of resveratrol (RESV) against HIE by modulating Nrf2/HO-1 pathway in neonatal rats. Read More

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http://dx.doi.org/10.1080/13880209.2018.1502326DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249550PMC
December 2018
19 Reads

Mechanism of TangGanJian on nonalcoholic fatty liver disease with type 2 diabetes mellitus.

Pharm Biol 2018 Dec;56(1):567-572

h Department of Management , Xinjiang Uygur Pharmaceutical Co., Ltd. , Wulumuqi , PR China.

Context: TangGanJian (TGJ) has a curative effect in the clinical treatment of nonalcoholic fatty liver disease (NAFLD) with type 2 diabetes mellitus (T2DM), while the mechanism involved in the treatment process remains unclear.

Objective: This study details the mechanism of TGJ on the treatment of NAFLD with T2DM.

Materials And Methods: NAFLD was induced in T2DM rat model. Read More

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http://dx.doi.org/10.1080/13880209.2018.1504972DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249541PMC
December 2018
23 Reads

Bioactive metabolites from the leaves of Withania adpressa.

Pharm Biol 2018 Dec;56(1):505-510

a Department of Biology, Faculty of Sciences Semlalia, Laboratory of Biotechnology, Protection and Valorisation of Plant Resources (URAC35 association Unit) , Cadi Ayyad University , Marrakech , Morocco.

Context: Withania (Solanaceae) species are known to be a rich source of withanolides, which have shown several biological properties.

Objective: To identify the compounds responsible for Withania adpressa Coss. antioxidant activity and further test them for their NF-κB inhibition and antiproliferative activity in multiple myeloma cells. Read More

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https://www.tandfonline.com/doi/full/10.1080/13880209.2018.1
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http://dx.doi.org/10.1080/13880209.2018.1499781DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249549PMC
December 2018
20 Reads

Ma Huang Tang ameliorates bronchial asthma symptoms through the TLR9 pathway.

Pharm Biol 2018 Dec;56(1):580-593

a School of Traditional Chinese Materia Medica , Shenyang Pharmaceutical University , Shenyang , China.

Context: Ma Huang Tang (MHT) has been used to treat influenza, fever, bronchial asthma, etc. as a traditional Chinese medication. However, the anti-inflammation mechanism of MHT remains unclear. Read More

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https://www.tandfonline.com/doi/full/10.1080/13880209.2018.1
Publisher Site
http://dx.doi.org/10.1080/13880209.2018.1517184DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6237163PMC
December 2018
12 Reads

Phylogenetic analysis of Uncaria species based on internal transcribed spacer (ITS) region and ITS2 secondary structure.

Pharm Biol 2018 Dec;56(1):548-558

b School of Traditional Chinese Medicine , Guangdong Pharmaceutical University , Guangzhou , People's Republic of China.

Context: The plant genus Uncaria (Rubiaceae), also known as Gouteng, is the source of an important traditional Chinese medicine. Misidentification and adulteration of Gouteng affect the safety and efficacy of the medication. Phylogenetic relationships among the species of this genus are unknown. Read More

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http://dx.doi.org/10.1080/13880209.2018.1499780DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225500PMC
December 2018
2 Reads
1.340 Impact Factor

Anti-inflammatory effects of shikonin in human periodontal ligament cells.

Pharm Biol 2018 Dec;56(1):415-421

a Tissue Repair and Regeneration Program , Institute of Health and Biomedical Innovation, Queensland University of Technology , Brisbane , Australia.

Context: Shikonin (SHI), an active component extracted from Radix Arnebiae, has been reported to possess anti-inflammatory properties in various cells. However, its effect on lipopolysaccharide (LPS)-stimulated human periodontal ligament cells (hPDLCs) is unknown.

Objective: To investigate the effects of SHI on the expression of inflammatory related cytokines in LPS-stimulated hPDLCs. Read More

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https://www.tandfonline.com/doi/full/10.1080/13880209.2018.1
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http://dx.doi.org/10.1080/13880209.2018.1506482DOI Listing
December 2018
19 Reads

Green synthesis of selenium nanoparticles with extract of hawthorn fruit induced HepG2 cells apoptosis.

Pharm Biol 2018 Dec;56(1):528-534

a School of Pharmaceutical Science , Shanxi Medical University , Taiyuan , PR China.

Context: Selenium nanoparticles (SeNPs) have attracted worldwide attention due to their unique properties and potential bioactivities. Considering that hawthorn is both a traditional medicine and a common edible food, hawthorn fruit extract (HE) was chosen as a reductant to prepare SeNPs.

Objective: SeNPs were synthesized by using an aqueous HE as a reductant and stabilizer. Read More

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https://www.tandfonline.com/doi/full/10.1080/13880209.2018.1
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http://dx.doi.org/10.1080/13880209.2018.1510974DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225412PMC
December 2018
14 Reads

Crataegus aronia enhances sperm parameters and preserves testicular architecture in both control and non-alcoholic fatty liver disease-induced rats.

Authors:
Mohammad Dallak

Pharm Biol 2018 Dec;56(1):535-547

a Department of Physiology , College of Medicine, King Khalid University , Abha , Saudi Arabia.

Context: Crataegus aronia (syn. Azarolus L.) (Rosaceae) is used in traditional medicine due to its hypolipidaemic and antioxidant properties. Read More

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https://www.tandfonline.com/doi/full/10.1080/13880209.2018.1
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http://dx.doi.org/10.1080/13880209.2018.1523934DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6211218PMC
December 2018
7 Reads

Safranal-promoted differentiation and survival of dopaminergic neurons in an animal model of Parkinson's disease.

Authors:
Yi Zhao Gangming Xi

Pharm Biol 2018 Dec;56(1):450-454

a Neurology Department of Xuhui Central Hospital , ShangHai , China.

Context: Safranal (SAF) is verified to have potential effects in promoting nerve growth.

Objectives: This study verifies the role of SAF in promoting dopaminergic neurons growth in vitro and in vivo.

Material And Methods: Rat neural stem cells (NSC) were treated with 1, 20, or 100 ng/mL of SAF, and the expression levels of tyrosine hydroxylase (TH) and dopamine transporter (DAT) were assayed by flow cytometry and real-time PCR and the secretion of dopamine (DA) was assayed by ELISA. Read More

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http://dx.doi.org/10.1080/13880209.2018.1501705DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6201804PMC
December 2018
12 Reads

Effects of psoralen on the pharmacokinetics of anastrozole in rats.

Pharm Biol 2018 Dec;56(1):433-439

a TCM Department of Breast , Longhua Hospital Affiliated to Shanghai University of TCM , Shanghai , China.

Context: Psoralen and anastrozole are always used together for breast cancer patients in Chinese clinics.

Objective: This study investigates the effects of psoralen on the pharmacokinetics of anastrozole in rats and its potential mechanism.

Materials And Methods: The pharmacokinetics of orally administered anastrozole (0. Read More

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http://dx.doi.org/10.1080/13880209.2018.1501584DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6201813PMC
December 2018
1 Read

Echinacea biotechnology: advances, commercialization and future considerations.

Pharm Biol 2018 Dec;56(1):485-494

a Ottawa-Carleton Institute of Biology , Ottawa , ON , Canada.

Context: Plants of the genus Echinacea (Asteraceae) are among the most popular herbal supplements on the market today. Recent studies indicate there are potential new applications and emerging markets for this natural health product (NHP).

Objective: This review aims to synthesize recent developments in Echinacea biotechnology and to identify promising applications for these advances in the industry. Read More

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https://www.tandfonline.com/doi/full/10.1080/13880209.2018.1
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http://dx.doi.org/10.1080/13880209.2018.1501583DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6179083PMC
December 2018
17 Reads

Dicranopteris linearis extract inhibits the proliferation of human breast cancer cell line (MDA-MB-231) via induction of S-phase arrest and apoptosis.

Pharm Biol 2018 Dec;56(1):422-432

a Halal Products Development, Halal Products Research Institute , Universiti Putra Malaysia (UPM) Serdang , Selangor , Malaysia.

Context: Dicranopteris linearis (Burm.f.) Underw. Read More

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https://www.tandfonline.com/doi/full/10.1080/13880209.2018.1
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http://dx.doi.org/10.1080/13880209.2018.1495748DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6179048PMC
December 2018
5 Reads

3,3'-Diindolylmethane enhances apoptosis in docetaxel-treated breast cancer cells by generation of reactive oxygen species.

Pharm Biol 2018 Dec;56(1):407-414

a Department of Surgery , Thomas Jefferson University , Philadelphia , PA , USA.

Context: A major problem in the treatment of cancer is the development of toxic side effects and resistance to chemotherapy. The use of plant compounds to overcome resistance and prevent toxicity is a potential strategy for treatment.

Objective: We evaluated whether 3,3'-diindolylmethane (DIM) enhanced the sensitivity of breast cancer cells to docetaxel (DOC). Read More

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http://dx.doi.org/10.1080/13880209.2018.1495747DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6179060PMC
December 2018
2 Reads

Synthesis, characterization and evaluation of transfection efficiency of dexamethasone conjugated poly(propyleneimine) nanocarriers for gene delivery#.

Pharm Biol 2018 Dec;56(1):519-527

e Targeted Drug Delivery Research Center, Institute of Pharmaceutical Technology , Mashhad University of Medical Sciences , Mashhad , Iran.

Context: Polypropylenimine (PPI), a cationic dendrimer with defined structure and positive surface charge, is a potent non-viral vector. Dexamethasone (Dexa) conveys to the nucleus through interaction with its intracellular receptor.

Objective: This study develops efficient and non-toxic gene carriers through conjugation of Dexa at various percentages (5, 10 and 20%) to the fourth and the fifth generation PPIs (PPIG4s and PPIG5s). Read More

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http://dx.doi.org/10.1080/13880209.2018.1517183DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6171438PMC
December 2018
2 Reads
1.340 Impact Factor

Bioinformatics analysis to identify action targets in NCI-N87 gastric cancer cells exposed to quercetin.

Pharm Biol 2018 Dec;56(1):393-398

b Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine (TCM) Prevention and Treatment of Tumor , Nanjing University of Chinese Medicine , Nanjing , Jiangsu , China.

Context: Quercetin exerts antiproliferative effects on gastric cancer. However, its mechanisms of action on gastric cancer have not been comprehensively revealed.

Objective: We investigated the mechanisms of action of quercetin against gastric cancer cells. Read More

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http://dx.doi.org/10.1080/13880209.2018.1493610DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6171422PMC
December 2018
2 Reads

Enhanced production of tanshinone IIA in endophytic fungi Emericella foeniculicola by genome shuffling.

Pharm Biol 2018 Dec;56(1):357-362

a College of Life Sciences , Shaanxi Normal University, Chang'an Campus , Xi'an , Shaanxi , China.

Context: Tanshinone IIA, commercially produced from Salvia miltiorrhiza Bunge (C.Y.Wu) (Labiatae), has various biological benefits. Read More

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https://www.tandfonline.com/doi/full/10.1080/13880209.2018.1
Publisher Site
http://dx.doi.org/10.1080/13880209.2018.1481108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6171462PMC
December 2018
14 Reads

Adaptation of a microbead assay for the easy evaluation of traditional anti-sickling medicines: application to DREPANOSTAT and FACA.

Pharm Biol 2018 Dec;56(1):385-392

a Pharma-Dev, UMR 152 , Université de Toulouse, IRD, UPS , Toulouse , France.

Context: Sickle cell disease is a common inherited blood disorder affecting millions of people worldwide. Due to lack of progress in drug discovery for a suitable treatment, sufferers often turn to traditional medicines that take advantage of the plant extracts activity used by traditional healers.

Objective: This study optimizes an anti-sickling screening test to identify preparations capable of reverting sickle cells back to the morphology of normal red blood cells. Read More

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http://dx.doi.org/10.1080/13880209.2018.1501585DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161593PMC
December 2018
12 Reads

Some pharmacokinetic parameters of salvianolic acid A following single-dose oral administration to rats.

Pharm Biol 2018 Dec;56(1):399-406

a Department of Pharmacy , The Affiliated Hospital of Qingdao University , Qingdao , People's Republic of China.

Context: Salvianolic acid A (Sal A) is a hydrophilic bioactive compound isolated from Salvia miltiorrhiza Bunge (Lamiaceae). It exerts beneficial effects after oral administration on diabetic complications.

Objective: To systematically study the absorption, distribution and excretion of Sal A after single-dose oral administration. Read More

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http://dx.doi.org/10.1080/13880209.2018.1491998DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6130628PMC
December 2018
28 Reads