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Digit J Ophthalmol 2018 18;24(4):27-30. Epub 2018 Oct 18.

Department of Ophthalmology, University of North Carolina, Chapel Hill, North Carolina.

We describe a case of penetrating eye injury that resulted in a post-injury day 1 hypopyon, leading to concern for endophthalmitis and phacoanaphylaxis. A Gram stain prepared by the clinical microbiology laboratory was interpreted as Gram-positive cocci (GPC). However, when cultures returned negative, further investigation with microbiology and pathology found that what was thought to be GPC was actually iris melanin pigment. Read More

Ocul Immunol Inflamm 2018 29;26(8):1278-1282. Epub 2017 Sep 29.

a Department of Ophthalmology and Pathology, USC Roski Eye Institute , Keck School of Medicine of the University of Southern California , Los Angeles , California , USA.

Purpose: To describe an unusual case of panuveitis in coexisting choroidal melanoma and phacoanaphylaxis.

Methods: Clinical records of the patient with intraocular melanoma and pathologic findings of the affected eye were reviewed. Composition of inflammatory infiltrates involving the tumor and lens was evaluated immunohistochemically. Read More

Surv Ophthalmol 2016 Sep-Oct;61(5):680-8. Epub 2016 Apr 27.

Department of Ophthalmology, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA.

Medical historians identify the mid-20th century as the time when the scientific and medical communities acknowledged the existence of autoimmune disease. Several conditions including sympathetic ophthalmia and endophthalmitis phacoanaphylactica, however, were proposed as autoimmune disorders much earlier. During the first half of the century, autoimmune disease was viewed as biologically implausible. Read More

J Cataract Refract Surg 2010 Oct;36(10):1687-91

Department of Ophthalmology, Peking University People's Hospital, Beijing, China.

Purpose: To study the effect on visual acuity of surgical management of late capsular block syndrome (CBS) and the possible complications.

Setting: Department of Ophthalmology, Peking University People's Hospital, Beijing, China.

Methods: In this retrospective observational series, records of patients who had late postoperative CBS and surgical management between January 2006 and December 2009 at the same hospital were drawn from a computerized database and reviewed. Read More

Eur J Ophthalmol 2009 Mar-Apr;19(2):201-6

Department of Ophthalmology, Affiliated Hospital of Medical College, Qingdao University, Qingdao - China.

Purpose: To study the cause, treatment, and cure of traumatic secondary glaucoma in 103 cases (103 eyes).

Methods: The records of 103 patients (103 eyes) were reviewed. Causes of the high intraocular pressure (IOP) were analyzed according to the time after trauma. Read More

Br J Ophthalmol 2005 Nov;89(11):1532-3

Ophthalmology 2003 Oct;110(10):1942-5

Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, 7-15-703 Kuromon, Chuo-ku, Fukuoka 810-0055, Japan.

Purpose: To describe the occurrence of phacoanaphylaxis in enucleated eyes of patients with Behçet's disease.

Design: Retrospective, observational, case series and human tissue study.

Participants: Twenty-six patients with Behçet's disease who underwent enucleation. Read More

Allergy Asthma Proc 2001 Jan-Feb;22(1):25-8

Immuno-Ophthalmology Service, UMDNJ-New Jersey Medical School, 90 Bergen Street, DOC Suite 4700, Newark, NJ 07103-2499, USA.

The objective of this article is to provide an overview of the present state of treatment of ocular allergy. Immuno-ophthalmology arose in the portion of this past century when investigators uncovered the uniqueness of the lens proteins and that it could induce an immunological response otherwise know as phacoanaphylaxis. Further studies have shown many similarities between the eye and other organ systems, but one of the most profound problems was the spring "catarrh" that involved the eyes and nose, i. Read More

Ophthalmology 2000 Nov;107(11):2111-4

Department of Ophthalmology, Emory University School of Medicine, Atlanta, Georgia, USA.

Objective: To report the clinicopathologic features of four eyes enucleated for late-onset bleb-related endophthalmitis.

Study Design: Retrospective case series.

Materials: Four enucleated eyes. Read More

Klin Monbl Augenheilkd 1996 Oct;209(4):228-31

Universitäts-Augenklinik Köln.

Background: Keratitis, retinitis and secondary cataract are well known complications of ocular herpes simplex infection. We report on a case of herpetic keratouveitis and cataract. Acute and inflammatory pathogenesis of cataract formation resemble a phacoanaphylactic reaction. Read More

Ger J Ophthalmol 1996 Mar;5(2):98-103

Universitäts-Augenklinik, Freiburg, Germany.

We present histological and immunohistochemical data on four cases of sympathetic ophthalmia, a disease that is believed to occur predominantly after perforating injury to the eye. Only a few cases without previous perforation have been reported. Nevertheless, sympathetic ophthalmia should be taken into consideration if there is a bilateral intraocular inflammation, even without trauma, as in two of our cases (cases 1 and 2). Read More

Ophthalmology 1993 Mar;100(3):377-83

Department of Pathology, Duke University Medical Center, Durham, North Carolina 27710.

Background And Methods: The authors report the clinical and ocular histopathologic findings in three patients with longstanding unilateral post-traumatic blindness. After one or more decades, acute pain associated with conjunctival hyperemia and apparent keratoprecipitates or a hypopyon developed in the affected eye of each individual. Phacoanaphylaxis was diagnosed preoperatively in two patients. Read More

Doc Ophthalmol 1992 ;81(3):317-38

Department of Ophthalmology, Lenox Hill Hospital, New York.

The crystalline lens is implicated as a causative element in producing several forms of glaucoma. Etiologically they represent a diversity in the presentation of the glaucomatous process. These conditions include glaucoma related to: lens dislocation (ectopia lentis), lens swelling (intumescent cataract), classical pupillary block, aqueous misdirection--ciliary block, phacoanaphylaxis, lens particle, and phacolytic glaucoma. Read More

Klin Monbl Augenheilkd 1990 Jun;196(6):495-501

Augenklinik der RWTH Aachen.

Postoperative inflammation is one of the oldest complications of cataract surgery. It was described by the Indian Susruta as early as 500 BC. Following the introduction of cataract extraction by Daviel in 1745, these operations attracted increasing interest. Read More

J Cataract Refract Surg 1989 Nov;15(6):698-701

Yale New Haven Hospital, Yale University School of Medicine, Connecticut 06510-8061.

An unusual clinical presentation of Propionibacterium acnes endophthalmitis as a solitary nodule on the corneal endothelial surface at the superior limbus in association with granulomatous uveitis is reported. The patient had previous extracapsular cataract surgery with intraocular lens implantation and two subsequent YAG laser capsulotomies. The organism was grown from a microbiopsy of the nodule after a negative anterior chamber tap. Read More

Br J Ophthalmol 1985 Nov;69(11):836-40

We describe the histopathological findings of an enucleation specimen from a clinically undiagnosed case of phacoanaphylaxis which occurred after extracapsular cataract extraction with intraocular lens implantation. Phacoanaphylaxis, a granulomatous inflammatory response to liberated lens protein, is potentially curable by prompt removal of residual lens material. This case emphasises that the diagnosis of phacoanaphylactic endophthalmitis should be considered in any case of extracapsular cataract extraction complicated by granulomatous intraocular inflammation. Read More

Bull Soc Ophtalmol Fr 1985 Jun-Jul;85(6-7):761-3

Arch Ophthalmol 1977 Feb;95(2):244-6

Phacoanaphylaxis (lens-induced uveitis) is a potentially curable ocular inflammation secondary to lens truma. Recently we have seen three clinically undiagnosed enucleation specimens in our eye pathology laboratory with this entity. Our observations add an argument to the recent concept that early lens removal in cases of traumatic cataract with lens capsule rupture would ultimately lead to better visual results. Read More

Ophthalmic Surg 1976 ;7(3):65-8

A case of phacoanaphylaxis following phacoemulsification is presented. The unusual features of the disease included the markedly delayed onset and the clinical appearance of the hypopyon. Emphasis is placed on the cytologic examination of anterior chamber aspirate in such cases. Read More

Am J Ophthalmol 1967 Feb;63(2):280-3

Arch Ophthalmol 1964 Jul;72:9-15

Am J Ophthalmol 1948 Aug;31(8):1004