2,430 results match your criteria Peyronie Disease

Sonic Hedgehog Signaling in Primary Culture of Human Corpora Cavernosal Tissue From Prostatectomy, Diabetic, and Peyronie's Patients.

J Sex Med 2022 Jun 22. Epub 2022 Jun 22.

Departments of Urology, Physiology, Bioengineering, and Biochemistry, University of Illinois at Chicago, Chicago, IL. Electronic address:

Background: Cavernous nerve (CN) injury causes penile remodeling, including smooth muscle apoptosis and increased collagen, which results in erectile dysfunction (ED), and prevention of this remodeling is critical for novel ED therapy development.

Aim: We developed 2 peptide amphiphile (PA) hydrogel delivery vehicles for Sonic hedgehog (SHH) protein to the penis and CN, which effectively suppress penile distrophic remodeling (apoptosis and fibrosis), in vivo in a rat CN injury model, and the aim of this study is to determine if SHH PA can be used to regenerate human corpora cavernosal smooth muscle deriving from multiple ED origins.

Methods: Corpora cavernosal tissue was obtained from prostatectomy, diabetic, hypertension, cardiovascular disease and Peyronie's (control) patients (n = 21). Read More

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Medium-long-term outcomes of saphenous vein graft in Peyronie surgery: Is there a need for new graft material?

Yavuz Güler

Rev Int Androl 2022 Jun 16. Epub 2022 Jun 16.

Private Safa Hospital, Urology Clinics, Istanbul, Turkey. Electronic address:

Aim: We present our results of tunical incision and saphenous graft surgery for men with short penis and who cannot have sexual relations due to curvature linked to chronic Peyronie plaques.

Introduction: Peyronie disease is a chronic process where fibrotic plaques form in the tunica albuginea. The plaques cause pain in the acute period and cause the penis to bend after inflammation ends. Read More

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An unusual presentation of penile Mondor's disease in an HIV-positive patient.

Ann R Coll Surg Engl 2022 May 31. Epub 2022 May 31.

Cochin Hospital, Assistance Publique-Hôpitaux de Paris, Paris Descartes University, France.

Penile Mondor's disease (PMD), or thrombosis of the dorsal vein, is an under-reported benign condition. Its aetiology is poorly understood. Clinically, it presents as a palpable cord in the dorsal vein of the penis, with pain or local discomfort, especially during erection. Read More

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Are insulin resistance and non-alcoholic fatty liver disease associated with Peyronie's disease? A pilot study.

J Physiol Pharmacol 2022 Feb 27;73(1). Epub 2022 May 27.

Department of Clinical Medicine and Surgery, University of Naples "Federico II", Naples, Italy.

Risk factors for Peyronie's disease (PD) are serum lipid abnormalities, hypertension and type 2 diabetes mellitus (T2DM). Oxidative stress and inflammation are key-players in the pathogenesis of arterial diseases, leading to insulin resistance (IR), which is a major determinant of non-alcoholic fatty liver disease (NAFLD). We studied the potential relationship between PD, IR, and NAFLD. Read More

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February 2022

Prolonged oral sildenafil use-induced Mondor disease: a case report.

J Yeungnam Med Sci 2022 May 24. Epub 2022 May 24.

Department of Emergency Medicine, Yeungnam University College of Medicine, Daegu, Korea.

Penile Mondor disease (MD) is a palpable, painful, subcutaneous induration caused by superficial dorsal penile vein thrombosis. We report a case of penile MD that was suspected to be related to prolonged oral sildenafil use. A 46-year-old man visited our emergency department with sustained penile pain and swelling that began 7 hours after sexual intercourse. Read More

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The contribution of the immune system to genitourinary fibrosis.

Exp Biol Med (Maywood) 2022 05 7;247(9):765-778. Epub 2022 May 7.

Department of Urology, University of Rochester Medical Center, Rochester, NY 14642, USA.

Fibrotic diseases of the genitourinary tract are devastating and incompletely understood pathologies. These diseases include urethral and ureteral strictures, retroperitoneal fibrosis, and Peyronie's disease. They can contribute to obstructive uropathy and sexual dysfunction. Read More

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Autologous testicular tunica vaginalis graft in Peyronie's disease: a prospective evaluation.

Int Urol Nephrol 2022 Jul 3;54(7):1545-1550. Epub 2022 May 3.

Department of Urology and Andrology, Astana Medical University, Beibitshilik Street #49/a, 010000, Nur-Sultan, Kazakhstan.

Background: Peyronie's disease (PD) is a two-phase progressive condition characterized by inelastic plaques in the tunica albuginea of the penis, leading to curvature of the penis. Men with PD also suffer from psychological distress, and sexual life and overall quality of life. Although the preferred surgical treatment modality in Peyronie's disease is plaque incision and grafting, there is lack of studies assessing the erectile function and penile vasculature after the treatment. Read More

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Multiple plaque incisions with or without grafting for Peyronie's disease.

BJUI Compass 2022 May 12;3(3):220-225. Epub 2022 Jan 12.

Total Urology Affidea Diagnostics Cork Ireland.

Objectives: To assess novel surgical techniques in management of Peyronie's disease.

Subjects: Forty-three men underwent corrective surgery using either partial plaque incision and nongraft (PPING) or multiple plaque incisions and graft (MPIG). The technique used was determined intra-operatively. Read More

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Cost of Intralesional Collagenase Clostridium Histiolyticum Therapy Versus Surgery for the Management of Peyronie's Disease: A Claims-Based Analysis (2009-2019).

Sex Med 2022 Jun 21;10(3):100517. Epub 2022 Apr 21.

Department of Urology, Emory University School of Medicine, Atlanta, GA, USA. Electronic address:

Background: Collagenase Clostridium histolyticum (CCH), which was approved by the FDA for the treatment of Peyronie's disease (PD) in 2013, may obviate the need for surgery but its historically high cost must be considered when offering CCH vs surgical intervention to affected patients.

Aim: To compare trends of intralesional injections vs surgical treatment for PD and assess the contemporary cost of treatment with CCH vs surgical intervention.

Methods: We reviewed 2009-2019 MarketScan Commercial Claims data to identify all men 18 years and older with PD. Read More

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Plaque excision with the Shah Penile Implant™ and tunica vaginalis graft in Peyronie's disease with erectile dysfunction: A case report.

Int J Surg Case Rep 2022 May 5;94:106976. Epub 2022 Apr 5.

Andrologia Internazionale Rome, Italy.

Peyronie's disease (PD) is a condition characterized by the deposition of scar tissue in the tunica albuginea of the penis. Peyronie's disease often causes pain, worsens the quality of erections, a variable degree of penile deformation and shortening, which can cause severe distress for the patient and the partner and impact negatively on self-esteem and quality of life in general. Surgery still represents the gold standard treatment for PD in the chronic phase, and it aims to guarantee a penis straight and rigid enough to allow the patient to resume penetrative sex with confidence. Read More

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Complete Plaque Regression in Patients with Peyronie's Disease After Multimodal Treatment with Antioxidants: A Report of 2 Cases.

Am J Case Rep 2022 Apr 17;23:e936146. Epub 2022 Apr 17.

Ultrasound Diagnostics Section, Department of Uro-Andrology, Castelfidardo Medical Team, Castelfidardo Clinical Analysis Center, Rome, Italy.

BACKGROUND Peyronie's disease is a chronic inflammatory disease involving the tunica albuginea of the penile corpora cavernosa. Conservative medical treatment includes oral therapy, intralesional injections, and physical treatment. No cases of Peyronie's disease with complete plaque regression after conservative medical treatment are described in the literature. Read More

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Effects of plication procedures in special cases of Peyronie's disease: a single-center retrospective study of 72 patients.

Asian J Androl 2022 May-Jun;24(3):294-298

Department of Urology and Andrology, Ninth People's Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200011, China.

General recommendations regarding surgical techniques are not always appropriate for all Peyronie's disease (PD) patients. Therefore, the purpose of this study was to investigate the effects of plication procedures in PD patients with severe penile curvature and the effects of early surgical correction in patients who no longer have progressive deformities. The clinical data from 72 patients who underwent plication procedures were analyzed in this study. Read More

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Orchio-Septopexy: A new technique to cover and fix detorsed testis undergoing fasciotomy of tunica albuginea.

Int Braz J Urol 2022 Jul-Aug;48(4):706-711

Department of Surgery, Division of Pediatric Urology, Sidra Medicine, Doha, Qatar.

Purpose: Compartment Syndrome (CS) has been recognized as a potential factor that worsens testicular viability after detorsion, especially in borderline cases of prolonged ischemia. Fasciotomy of the testicular tunica albuginea to relieve the pressure associated with CS has been proposed to accommodate edema after detorsion, embracing the raw fasciotomy area with tunica vaginalis flap (TVF) or graft. Fashioning the TVF can be tedious in cases of severe scrotal edema. Read More

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The use of a polyglycolic acid polymer graft in Peyronie's disease - preliminary outcomes.

Arch Ital Urol Androl 2022 Mar 29;94(1):87-90. Epub 2022 Mar 29.

Department of Anesthesiology of Hospital Governador Celso Ramos, Florianópolis.

Objective: Plaque incision and grafting is indicated for patients with Peyronie's Disease [PD] and severe curvature, complex deformities or for patients with significant penile shortening. To date, no graft studied has been considered ideal. The aim of this study is to conduct a descriptive analysis about functional results with the use of a bioabsorbable graft for PD treatment. Read More

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Quality of life of patients with La Peyronie's disease undergoing local iontophoresis therapy: A longitudinal observational study.

Arch Ital Urol Androl 2022 Mar 29;94(1):75-79. Epub 2022 Mar 29.

City of Alessandria Clinic Monza Polyclinic, Alessandria.

Objectives: La Peyronie's disease tends to be underdiagnosed and undertreated. In Italy it affects about 7% of the population aged between 50 and 70 years old. The aim of this study is to evaluate the quality of life of patients undergoing iontophoretic therapy with verapamil and treatment outcomes at a two-year interval. Read More

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Is There Still a Role for Vacuum Erection Devices in Contemporary Sexual Medicine?

Run Wang

J Sex Med 2022 05 20;19(5):682-685. Epub 2022 Mar 20.

Director of Sexual Medicine Fellowship Program, University of Texas McGovern Medical School and MD Anderson Cancer Center, Houston, TX. Electronic address:

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Penile Plication for Peyronie's Disease: The Iterative 8-Dot Technique.

Urology 2022 Jun 15;164:e307. Epub 2022 Mar 15.

Department of Urology, University of North Carolina, Chapel Hill, NC. Electronic address:

Introduction: Penile plication is a minimally invasive and effective technique for managing mild to severe curvature from Peyronie's disease.

Methods: Retrospective chart review of all patients undergoing penile plication for Peyronie's disease by one surgeon at one academic institution from November 2016-December 2020 was conducted. Those occurring during IPP placement were excluded. Read More

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Evaluating the efficacy of intraplaque injection of dexamethasone with oral tadalafil in the chordee patients with Peyronie disease.

Am J Clin Exp Urol 2022 15;10(1):25-30. Epub 2022 Feb 15.

Department of Urology, Al-Zahra Hospital, Isfahan University of Medical Sciences Isfahan, Iran.

Background: Some studies demonstrated the effect of the combination of modalities in Peyronie's disease (PD) therapy; however, there is no comprehensive study for evaluation of dexamethasone and phosphodiesterase type 5 (PDE5) inhibitors such as tadalafil in the treatment of PD, so the study aimed to evaluate the efficacy of intraplaque injection of dexamethasone with oral tadalafil in the patients with PD.

Materials And Methods: This double-blinded randomized, controlled trial was conducted on the patients with PD referred to Alzahra and Khorshid hospitals, Isfahan, Iran. Then the patients were randomly divided into two groups as intervention and control groups. Read More

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February 2022

Efficacy and Safety of Collagenase Clostridium Histolyticum in the Treatment of Peyronie's Disease: An Evidence-Based Analysis.

Front Med (Lausanne) 2022 18;9:780956. Epub 2022 Feb 18.

Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, China.

Background: Peyronie's disease (PD) is a chronic wound healing disorder, mainly involving tunica albuginea. Collagenase Clostridium Histolyticum (CCH) has shown its effectiveness in treating PD, but its efficacy and safety remain controversial, which propelled us to conduct the first evidence-based research on this topic.

Methods: We searched the Web of Science, PubMed, Embase, and ClinicalTrials. Read More

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February 2022

Pre- and Post-Injection Needle Pain in Patients Undergoing First Intracavernosal Injection.

J Sex Med 2022 04 26;19(4):590-593. Epub 2022 Feb 26.

Department of Urology, Mayo Clinic Florida, Jacksonville, FL, USA.

Background: Intracavernosal injections (ICI) are a well-established treatment option for men with erectile dysfunction (ED); however, the anticipation of pain with injection remains a significant barrier to the use of ICI.

Aim: To evaluate the patient-anticipated degree of pain versus the experienced degree of pain pre- and post-ICI in men undergoing their first injection with an erectile agent.

Methods: We studied 51 patients who underwent their first ICI in our men's health clinic. Read More

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Grafting Area Reduction in Peyronie's Disease Surgery: Comparative Assessment Between Double Y Vs iGrafter APP Using 3D-Printed Penile Models.

J Sex Med 2022 04 23;19(4):669-675. Epub 2022 Feb 23.

Department of Urology, University of Arkansas for Medical Sciences, Little Rock, AR, USA. Electronic address:

Background: The use of plaque incision and graft techniques (PIG) for the treatment of severe Peyronie's disease (PD), may lead to erectile dysfunction (ED); graft size is 1 of the contributing factors for post-PIG ED. Recently the iGrafter software APP was introduced using a mathematical algorithm to distribute the incisions along the penile length resulting in a smaller grafting area.

Aim: Compare 2 PIG techniques, the Double-Y(DY) and iGrafter, in 3 main aspects: (i) Total grafting area; (ii) The variation in calculating the grafting to be used; (iii) time to perform the PIG. Read More

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Pharmacotherapy in Peyronie's disease: a state-of-the-art review on established contemporary and emerging drugs.

Expert Opin Pharmacother 2022 Feb 25:1-8. Epub 2022 Feb 25.

Department of Urology, University of California Irvine, Orange, CA, USA.

Introduction: Current clinical guidelines on Peyronie's disease (PD) advocate non-surgical treatment options as the first-line therapy despite inconsistent clinical outcomes when compared to definitive penile reconstructive surgery.

Areas Covered: This article examines the current understanding of established contemporary and emerging pharmacotherapies for PD. Emphasis has been placed on published clinical studies on drugs in the last 10 years. Read More

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February 2022

A Critical Analysis of Reporting in Systematic Reviews and Meta-Analyses in the Peyronie's Disease Literature.

J Sex Med 2022 04 15;19(4):629-640. Epub 2022 Feb 15.

Center for Men's Health, Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, OH, USA. Electronic address:

Background: Despite an increasing number of publications on Peyronie's disease (PD), evidence-based clinical decision-making remains challenging due to the small number of well-designed clinical trials.

Aim: To perform a critical analysis of reporting quality in PD systematic reviews (SR) and meta-analyses (MA).

Methods: Study protocol registration was performed on the Open Science Framework platform. Read More

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Penile Modeling in Peyronie's Disease: A Systematic Review of the Literature.

Sex Med Rev 2022 Feb 10. Epub 2022 Feb 10.

Department of Urology and Robotic Surgery, Hospital Universitario La Zarzuela, Madrid, Spain.

Introduction: Penile modeling to correct the penile curvature in Peyronie's disease (PD) may be achieved manually (intra-operatively or post-injection) or by using assisted devices (penile traction, vacuum device, or penile prosthesis).

Objectives: To evaluate the efficacy, safety, and satisfaction associated with penile modeling in patients with PD.

Methods: A PROSPERO registered (CRD42021241729) systematic search in MEDLINE and Cochrane Library was done following PRISMA. Read More

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February 2022

Emerging Roles of Penile Traction Therapy and Vacuum Erectile Devices.

Sex Med Rev 2022 Feb 1. Epub 2022 Feb 1.

Department of Surgery, Division of Urology, University of Texas McGovern Medical School, Houston, TX, USA; Department of Urology, MD Anderson Cancer Center, Houston, TX, USA. Electronic address:

Introduction: Penile traction therapy (PTT) and vacuum erection devices (VED) are nonsurgical conservative treatment options that have been used in the treatment of various urologic and sexual disorders such as Peyronie's Disease (PD) and Erectile Dysfunction (ED). Recently expanded uses for these therapies now include penile lengthening and with surgical interventions such as penile prosthesis surgery (PPS) and radical prostatectomy (RP). These devices can be used as both monotherapy or combination therapy. Read More

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February 2022

Shock Wave Therapy for Peyronie's Disease-Learning From the Past and Looking Into the Future.

J Sex Med 2022 03 26;19(3):404-407. Epub 2022 Jan 26.

Division of Urology, Western University Department of Surgery, St. Joseph's Health Care London, London, Ontario, Canada. Electronic address:

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Evaluation of penile curvature in patients with hypospadias; gaps in the current practice and future perspectives.

Tariq O Abbas

J Pediatr Urol 2022 Apr 31;18(2):151-159. Epub 2021 Dec 31.

Pediatric Urology Section, Sidra Medicine, Doha, Qatar; College of Medicine, Qatar University, Doha, Qatar; Weill Cornell Medicine Qatar, Doha, Qatar; Regenerative Medicine Research Group, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark. Electronic address:

Background/purpose: Penile curvature (PC) is a significant phenotypic anomaly associated with hypospadias that can affect hypospadias repair post-operative outcomes and impact on long-term quality of life as well as psychosexual wellbeing of affected patients. While several previous studies have attempted to define PC assessment criteria, there is still no accurate, reproducible, and reliable tool for quantifying severity. Our goal was to review the pros and cons of the current tools utilized for assessing the degree of PC in children, stressing on both strengths and limitations of each method. Read More

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ABO Blood Type and Risk of Peyronie's Disease in Japanese Males.

World J Mens Health 2022 Jan 1. Epub 2022 Jan 1.

Department of Urology, Toho University Faculty of Medicine, Tokyo, Japan.

Purpose: Although multiple mechanisms associated with Peyronie's disease (PD) have been proposed, details regarding etiologic factors, especially genetic, remain unclear. We examined the relationship of the ABO blood type system, known as a genetic factor associated with susceptibility to a number of diseases, with PD in Japanese males.

Materials And Methods: We compared 202 Japanese PD patients treated with surgery at our hospital between March 2004 and December 2019 with 846 randomly selected non-PD male patients who underwent urological surgery during the same period regarding distribution of ABO blood types. Read More

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January 2022

Surgical Correction of Adult Congenital Penile Curvature: A Systematic Review.

J Sex Med 2022 02 5;19(2):364-376. Epub 2022 Jan 5.

Department of Urology, Mayo Clinic, Rochester, MN, USA. Electronic address:

Background: Congenital penile curvature (CPC) is corrected surgically by various corporoplasty or tunica albuginea plication techniques, but the optimal surgical approach is not well-defined.

Aim: To provide a comprehensive evaluation of the published literature pertaining to outcomes with penile plication and corporoplasty techniques for surgical management of CPC. To determine if plication or corporoplasty offers superior outcomes in surgical correction of CPC. Read More

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February 2022

Laser Photobiomodulation of the Induratio Penis Plastica or La Peyronie's Syndrome.

Photobiomodul Photomed Laser Surg 2022 Apr 23;40(4):287-291. Epub 2021 Dec 23.

Department of Experimental and Clinical Medicine, Physiological Sciences Unit, University of Florence, Folrence, Italy.

Since 1980, laser therapy has been proposed with success in the treatment of the Induratio Penis Plastica (IPP), also called La Peyronie's Syndrome, but still few physicians use it. We would like to investigate the clinical effects of using more laser sequentially in each session, in the treatment of chronic IPP. We used high levels of energy, watts rather than milliwatts, reducing the duration of each application, and the number of the cycles in total. Read More

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