1,997 results match your criteria Peyronie Disease


Ten-year experience with multimodal treatment for acute phase Peyronie's disease: A real life clinical report.

Actas Urol Esp 2019 Jan 28. Epub 2019 Jan 28.

Gallo Uro-Andrology Centre, Nápoles, Italia.

Objectives: To present our experience with multimodal therapy for Peyronie's disease.

Methods: Retrospective data were collected since 2008 to 2017. The following features were evaluated at baseline and after treatment: age, duration of disease, erectile function, erected penile curvature, and stretched penile length. Read More

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http://dx.doi.org/10.1016/j.acuro.2018.08.005DOI Listing
January 2019

A Contemporary Evaluation of Peyronie's Disease During Penile Prosthesis Placement: MOST, MUST, and More.

Curr Urol Rep 2019 Jan 30;20(2). Epub 2019 Jan 30.

Division of Urology and Urologic Oncology, City Of Hope, 1500 East Duarte Ave, Duarte, CA, 91010, USA.

Purpose Of Review: The use of penile implant for the treatment of both erectile dysfunction and Peyronie's disease has changed little in the last 40 years, primarily limited to modeling and plaque incision. In the current review, I explore the history of Peyronie's treatment at the time of penile prosthesis placement and explore new surgical options that help resolve several of the issues that were not treated with the traditional approaches.

Recent Findings: Advancements have been made in the area of graft material, lengthening procedures, and transcorporal techniques. Read More

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http://dx.doi.org/10.1007/s11934-019-0870-zDOI Listing
January 2019

The prevalence of Peyronie's disease in diabetic patients -2018- Yazd.

Diabetes Metab Syndr 2019 Jan - Feb;13(1):604-607. Epub 2018 Nov 13.

Diabetes Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Electronic address:

Introduction: Peyronie's disease (PD) is the fibrous scar tissue inside the penis that causes curved and painful erections. PD is associated with, diabetes, hypertension, dyslipidemia and low testosterone. PD causes erectile dysfunction (ED). Read More

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http://dx.doi.org/10.1016/j.dsx.2018.11.039DOI Listing
November 2018
1 Read

Urologic conditions associated with malignancy.

Urol Oncol 2019 Jan 2. Epub 2019 Jan 2.

Division of Urology, Department of Surgery, University of Utah School of Medicine, Salt Lake City, UT. Electronic address:

Introduction: Recent advances in cancer research have highlighted the role of genetics in malignancy. Genetic dysregulation of core cellular functions similarly influences benign conditions. These common genetic factors have led researchers to identify an association between certain urologic conditions and malignancy. Read More

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http://dx.doi.org/10.1016/j.urolonc.2018.12.018DOI Listing
January 2019
2 Reads

The Impact of Clostridium Histolyticum Collagenase on the Prevalence and Management of Peyronie's Disease in the United States.

World J Mens Health 2018 Nov 30. Epub 2018 Nov 30.

Department of Urology, Stanford University, Stanford, CA, USA.

Purpose: We evaluated the impact of collagenase clostridium histolyticum (CCH) on rates of diagnosis, treatment, and corporal rupture in Peyronie's disease (PD). We examined the impact of CCH on cost of PD treatment.

Materials And Methods: We extracted data on PD diagnosis (ICD-9 607. Read More

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http://dx.doi.org/10.5534/wjmh.180073DOI Listing
November 2018

Simvastatin and the Rho-kinase inhibitor Y-27632 prevent myofibroblast transformation in Peyronie's disease-derived fibroblasts via inhibition of YAP/TAZ nuclear translocation.

BJU Int 2018 Dec 9. Epub 2018 Dec 9.

Laboratory of Experimental Urology, Department of Development and Regeneration, KU Leuven, Leuven, Belgium.

Objectives: To uncover the anti-myofibroblast (MFB) properties of Rho-kinase inhibitor (compound Y-27632) and simvastatin in an in vitro model of Peyronie's disease (PD), a sexually debilitating disease caused by an irreversible fibrotic plaque in the penile tunica albuginea (TA).

Materials And Methods: Primary human fibroblasts (FBs) were isolated from surgically obtained TA tissue from patients with PD. To induce MFB status, cells were stimulated with 3 ng/mL transforming growth factor-β1 (TGF-β1). Read More

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http://dx.doi.org/10.1111/bju.14638DOI Listing
December 2018
1 Read

What about the partner? -factors associated with patient-perceived partner dyspareunia in men with Peyronie's disease.

Transl Androl Urol 2018 Dec;7(6):935-940

Department of Urology, Mayo Clinic, Rochester, MN, USA.

Background: Limited data are available on how partners of men with Peyronie's disease (PD) are affected by the disease. We sought to characterize PD patients whose curvatures result in pain for their partners during penetrative intercourse.

Methods: We queried a database of all men undergoing initial evaluation for PD at a single clinic between March 2014 and June 2016. Read More

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http://dx.doi.org/10.21037/tau.2018.07.20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6256043PMC
December 2018
1 Read

Prevalence of penile curvature: a population-based cross-sectional study in metropolitan and rural cities in Australia.

BJU Int 2018 Nov;122 Suppl 5:42-49

Department of Urology, Western Health, Melbourne, Vic., Australia.

Objective: To evaluate the prevalence of penile curvature and health-seeking behaviour in Australian men.

Patients And Methods: A population-based, cross-sectional anonymous web-based survey was designed, and men aged between 35 and 75 years in major and rural metropolitan cities across Australia were invited to participate. Respondents were screened for self-reported symptoms of penile curvature and their impact on various psychosexual domains. Read More

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http://doi.wiley.com/10.1111/bju.14605
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http://dx.doi.org/10.1111/bju.14605DOI Listing
November 2018
1 Read
3.533 Impact Factor

Superficial radiation therapy in peyronie's disease: An effective and well-tolerated therapy.

Adv Radiat Oncol 2018 Oct-Dec;3(4):548-551. Epub 2018 Aug 7.

Klinik und Poliklinik für Dermatologie und Allergologie am Biederstein, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.

Purpose: This study aimed to assess the safety, efficacy, and patient satisfaction of superficial radiation therapy in the treatment of Peyronie's disease (PD) in a retrospective analysis.

Methods And Materials: We performed a retrospective analysis of 83 patients who underwent radiation therapy between 1999 and 2008 with 8 fractions of 4 Gy over a period of 6 months. With a mean follow-up time of 52 months, patients responded to a comprehensive questionnaire that covered patient characteristics, disease duration before radiation therapy, course of disease, treatment response, side effects, and patient satisfaction. Read More

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http://dx.doi.org/10.1016/j.adro.2018.07.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6200896PMC
August 2018
2 Reads

Long-term outcome after grafting with small intestinal submucosa and collagen fleece in patients with Peyronie´s disease: a matched pair analysis.

Int J Impot Res 2018 Oct 22. Epub 2018 Oct 22.

Department of Urology and Pediatric Urology, Julius-Maximilians-University of Würzburg, Würzburg, Germany.

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http://dx.doi.org/10.1038/s41443-018-0082-yDOI Listing
October 2018

Antifibrotic Synergy Between Phosphodiesterase Type 5 Inhibitors and Selective Oestrogen Receptor Modulators in Peyronie's Disease Models.

Eur Urol 2019 Feb 19;75(2):329-340. Epub 2018 Oct 19.

Anglia Ruskin University, Chelmsford, UK. Electronic address:

Background: Peyronie's disease (PD) is a fibrotic disorder of the penile tunica albuginea, characterised by the formation of a localised fibrous plaque that can lead to deformity and erectile dysfunction. Nonsurgical therapeutic options for PD are limited in efficacy and safety. Myofibroblasts are key cells in the pathogenesis of PD, and inhibition of myofibroblast transformation has been suggested as a therapeutic option. Read More

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http://dx.doi.org/10.1016/j.eururo.2018.10.014DOI Listing
February 2019
11 Reads

The comparison of an acellular matrix graft with an autologous venous graft in the surgical treatment of Peyronie's disease.

Andrologia 2019 Feb 9;51(1):e13168. Epub 2018 Oct 9.

Department of Urology, Ankara Ataturk Education and Research Hospital, Ankara, Turkey.

The aim of this study was to evaluate acellular porcine pericardium (APP) and compared the results with those obtained from venous grafts in the surgical management of Peyronie's disease (PD). An APP (Group 1) and an autologous saphenous vein graft (Group 2) were used in 27 and 26 patients, respectively for Peyronie's correction. The patients' age, body mass index (BMI), operation time, duration of follow-up, preoperative and postoperative IIEF-5 scores, plaque size and loss of sensation were evaluated in both groups. Read More

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http://dx.doi.org/10.1111/and.13168DOI Listing
February 2019
3 Reads

Intratunical Injection of Stromal vascular fraction prevents Fibrosis in a Rat Model of Peyronie's Disease.

BJU Int 2018 Sep 29. Epub 2018 Sep 29.

Laboratory for Experimental Urology, Organ systems, Department of Development and Regeneration, University of Leuven, Leuven, Belgium.

Objective: Previous studies have shown that the injection of adipose tissue-derived stem cells (ADSCs) into the tunica albuginea (TA) during the active phase of the Peyronie's disease (PD) prevents the development of fibrosis and elastosis in the TA and corpus cavernosum The aim of this study was to investigate whether local injection of autologous adipose stromal vascular fraction (SVF) can prevent the development of fibrosis and elastosis in the TA using a rat model of acute phase of the Peyronie's disease (PD) METHODS: A total of 24 male 12-wk-old Sprague-Dawley rats were divided in three equal groups: sham, PD without treatment (TGFB) and PD treated with SVF (SVF) 1 day after disease induction. Sham rats underwent 2 injections of vehicle into the TA one day apart. TGFB rats underwent TGF- β1 injection and injection of vehicle one day later. Read More

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http://dx.doi.org/10.1111/bju.14570DOI Listing
September 2018
7 Reads

Clinical Efficacy of Injection and Mechanical Therapy for Peyronie's Disease: A Systematic Review of the Literature.

Eur Urol 2018 12 17;74(6):767-781. Epub 2018 Sep 17.

Department of Urology, University Hospitals Leuven, Leuven, Belgium.

Context: Conservative therapies for Peyronie's disease (PD) aim to treat early-stage disease by improving clinical outcomes such as penile curvature, penile length erectile dysfunction, and pain.

Objective: To summarise the available evidence regarding injection and mechanical therapies for PD treatment.

Evidence Acquisition: An extensive search of Medline, Embase, and Scopus databases retrieved English-language articles up to 15 May 2018. Read More

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http://dx.doi.org/10.1016/j.eururo.2018.07.005DOI Listing
December 2018
2 Reads

Plication for Severe Peyronie's Deformities Has Similar Long-Term Outcomes to Milder Cases.

J Sex Med 2018 Oct 15;15(10):1498-1505. Epub 2018 Sep 15.

Department of Urology, University of Texas Southwestern Medical Center, Dallas, TX, USA. Electronic address:

Introduction: Penile plication (PP) for Peyronie's disease (PD) is an established treatment option for mild to moderate curvature, but scant data exist regarding its utility in severe deformities.

Aim: To evaluate long-term outcomes among men undergoing PP for PD, comparing severe to mild/moderate penile deformities.

Methods: We performed a retrospective review of patients who underwent PP for PD between 2009 and 2017. Read More

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http://dx.doi.org/10.1016/j.jsxm.2018.08.006DOI Listing
October 2018
9 Reads

Xiaflex for Treatment of Peyronie's Disease.

Eur Urol Focus 2018 04 10;4(3):302-303. Epub 2018 Sep 10.

Department of Urology, Hackensack University Medical Center, Hackensack, NJ, USA; Divsion of Urology, Rutgers New Jersey Medical School, Newark, NJ, USA.

Xiaflex or collagenase Clostridium histolyticum intralesional injections are safe and effective as first-line treatment for Peyronie's disease. Read More

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http://dx.doi.org/10.1016/j.euf.2018.08.021DOI Listing
April 2018
18 Reads

Surgical Management of Peyronie's Disease.

Eur Urol Focus 2018 04 8;4(3):304-306. Epub 2018 Sep 8.

Department of Urology, University of Miami, Miami, FL, USA. Electronic address:

When choosing a management strategy for a patient with Peyronie's disease (PD), it is critical to consider the phase of the disease, penile plaque characteristics, degree of curvature, associated deformities, stretched penile length, and baseline erectile function. Equally important is an understanding of the patient's goals and expectations. Treatment cost and duration may also be vital considerations for the patient. Read More

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http://dx.doi.org/10.1016/j.euf.2018.08.026DOI Listing
April 2018
2 Reads

Penile Sensory Changes After Plaque Incision and Grafting Surgery for Peyronie's Disease.

J Sex Med 2018 Oct 6;15(10):1491-1497. Epub 2018 Sep 6.

Male Sexual and Reproductive Medicine Program, Urology Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY, USA. Electronic address:

Introduction: Plaque incision and grafting (PIG) for Peyronie's disease (PD) is not devoid of complications such as erectile dysfunction and penile sensory changes.

Aim: To define the rate and chronology of penile sensation loss after PIG surgery and to define predictors of such.

Methods: The study population consisted of patients with PD-associated penile curvature who underwent PIG surgery with at least 6 months of follow-up. Read More

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http://dx.doi.org/10.1016/j.jsxm.2018.07.020DOI Listing
October 2018
11 Reads

Intralesional and Mechanical Therapies for Peyronie's Disease: A Road Anything but Straight.

Eur Urol 2018 12 31;74(6):782-783. Epub 2018 Aug 31.

Department of Urology, Herlev and Gentofte Hospital, Herlev, Denmark.

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http://dx.doi.org/10.1016/j.eururo.2018.08.017DOI Listing
December 2018

[Low-intensity extracorporeal shockwave therapy for Peyronie's disease: A preliminary study of 32 cases].

Zhonghua Nan Ke Xue 2018 Apr;24(4):340-344

Department of Andrology, Henan Provincial People's Hospital, Zhengzhou, Henan 450000, China.

Objective: To investigate the clinical effect of low-intensity extracorporeal shockwave therapy (LI-ESWT) on Peyronie's disease.

Methods: From October 2016 to December 2017, we treated 32 cases of Peyronie's disease by LI-ESWT, with the therapeutic index of 0.09 mJ/mm2 and a pulse frequency of 120 beats/min. Read More

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April 2018
11 Reads

[Plaque excision plus autologous perididymal patch grafting for Peyronie's disease].

Zhonghua Nan Ke Xue 2018 Janurary;24(1):55-58

Department of Urology, Xuzhou Hospital Affiliated to Southeast University School of Medicine, Xuzhou, Jiangsu 221009, China.

Objective: To investigate the clinical effect of plaque excision plus autologous perididymal patch grafting in the treatment of Peyronie's disease.

Methods: This study included 10 patients with Peyronie's disease received in our Department of Urology between January 2013 and December 2015, who had failed to respond to over 12 months of expectant drug therapy and remained stable for more than 6 months, none able to perform sexual intercourse due to penile curvature (>60°). All the patients underwent plaque excision plus autologous perididymal patch grafting. Read More

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November 2018
4 Reads

Penile lengthening with porcine small intestinal submucosa grafting in Peyronie's disease treatment: long-term surgical outcomes, patients' satisfaction and dissatisfaction predictors.

Andrology 2018 Nov 3;6(6):909-915. Epub 2018 Aug 3.

Nuno Tomada Urologia e Cirurgia Reconstrutiva, Porto, Portugal.

Background: Peyronie's Disease (PD) is an acquired connective tissue disorder that often leads to penile curvature (PC) and sexual dysfunction. Penile lengthening procedures (PLP) with four-layered porcine small intestinal submucosa graft (Surgisis ES; Cook) have been widely used in patients with severe PC when erectile function is preserved. However, complications such as erectile dysfunction (ED) may limit treatment satisfaction. Read More

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http://dx.doi.org/10.1111/andr.12522DOI Listing
November 2018
10 Reads

Phase I and phase II clinical trials for the treatment of male sexual dysfunction-a systematic review of the literature.

Expert Opin Investig Drugs 2018 Jul 11;27(7):583-593. Epub 2018 Jul 11.

a Department of Urology , Università Vita-Salute San Raffaele , Milan , Italy.

Introduction: The prevalence of sexual dysfunctions has increased over the last decades; despite a number of available treatments for erectile dysfunction (ED), premature ejaculation (PE), and Peyronie's disease (PD), still several unmet therapeutic needs deserve to be fulfilled. The aim of this review is to detail on phase I and II clinical trials investigating novel medical treatments for ED, PE, and PD. Areas covered: We conducted a systematic review of the literature including both published and ongoing phase I and II registered trials focused on medical treatment of ED, PE, and PD during the last 5 years. Read More

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http://dx.doi.org/10.1080/13543784.2018.1495707DOI Listing
July 2018
7 Reads

The Use of Stromal Vascular Fraction in the Treatment of Male Sexual Dysfunction: A Review of Preclinical and Clinical Studies.

Sex Med Rev 2018 Jun 27. Epub 2018 Jun 27.

Tulane University School of Medicine, Department of Urology, New Orleans, LA, USA. Electronic address:

Introduction: Stem cell therapy using stromal vascular fraction (SVF) is a promising treatment modality. SVF is comprised of a mixture of adipose-derived stem cells, endothelial precursor cells, and immune modulatory cells that act synergistically to facilitate angiogenesis and epithelial cell differentiation. This makes SVF an attractive option for men's sexual disorders that require reconstitution of vasculature and endothelial lining, namely erectile dysfunction (ED) and Peyronie's disease (PD). Read More

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http://dx.doi.org/10.1016/j.sxmr.2018.04.001DOI Listing
June 2018
16 Reads

Biomechanical Comparison of Inflatable Penile Implants: A Cadaveric Pilot Study.

J Sex Med 2018 Jul;15(7):1034-1040

Advanced Urology, Atlanta, GA, USA.

Background: Throughout the last decade there has been a growing interest in the biomechanical differences between inflatable penile prostheses (IPPs) and their significance with regard to the patient experience.

Aim: To present our findings assessing the biomechanical properties of IPPs with and without rear tip extenders (RTEs).

Methods: This is a biomechanical study of the 3 most commonly used IPPs (AMS CX, AMS LGX, and Coloplast Titan) as assessed by column compression, modified cantilever deflection, and 3-point bending methods. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S17436095183100
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http://dx.doi.org/10.1016/j.jsxm.2018.05.014DOI Listing
July 2018
18 Reads

Plaque Calcification: An Important Predictor of Collagenase Clostridium Histolyticum Treatment Outcomes for Men With Peyronie's Disease.

Urology 2018 Sep 10;119:109-114. Epub 2018 Aug 10.

Department of Urology, Mayo Clinic, Rochester, MN.

Objective: To compare outcomes of men with or without calcified plaques undergoing collagenase Clostridium histolyticum (CCH) injections for Peyronie's disease (PD) and identify predictors of CCH success.

Materials And Methods: From March 2014 through January 2017, data were prospectively collected on 192 patients who underwent 1-4 cycles of CCH for the treatment of PD. Of these, 115 completed ≥2 CCH cycles and had data on curvature assessment. Read More

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http://dx.doi.org/10.1016/j.urology.2018.06.003DOI Listing
September 2018
5 Reads

Reduction in Peyronie's-like plaque size using a vacuum erection device in a rat model of Peyronie's disease via the TGF-β/SMAD signalling pathway.

Andrologia 2018 Sep 28;50(7):e13051. Epub 2018 May 28.

Andrology Laboratory, West China Hospital, Sichuan University, Chengdu, China.

Peyronie's disease (PD) is a fibrotic disorder of the tunica albuginea (TA). This study aimed to determine the therapeutic effects of a vacuum erection device (VED) in an animal model of PD and explore the possible mechanisms. Twenty-seven male Sprague-Dawley rats were used. Read More

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http://dx.doi.org/10.1111/and.13051DOI Listing
September 2018
6 Reads

Surgical Outcomes of Plaque Excision and Grafting and Supplemental Tunica Albuginea Plication for Treatment of Peyronie's Disease With Severe Compound Curvature.

J Sex Med 2018 Jul 22;15(7):1021-1029. Epub 2018 May 22.

Department of Urology, Rush University Medical Center, Chicago, IL, USA.

Background: There are limited data in the literature that describe the management of Peyronie's disease (PD) with severe compound curvature, which often requires additional straightening procedures after plaque excision and grafting (PEG) to achieve functional penile straightening (<20 degrees).

Aim: This study highlights the clinical distinction and our experience with men with PD and severe compound curvature treated with PEG and supplemental tunica albuginea plication (TAP).

Methods: We performed a retrospective chart review of patients with PD and acute angulation who underwent PEG (group 1) and patients with compound curvature who underwent PEG with TAP (group 2) between 2007 and 2016. Read More

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http://dx.doi.org/10.1016/j.jsxm.2018.04.642DOI Listing
July 2018
3 Reads

Characterization of Septal and Punctate Scarring in Peyronie's Disease.

Urology 2018 Aug 22;118:87-91. Epub 2018 May 22.

Division of Urology, Department of Surgery, Western University, London, Ontario, Canada. Electronic address:

Objective: To characterize patients with isolated septal scarring (ISS) and punctate scarring (PS) in Peyronie's disease (PD) and to highlight the importance of duplex ultrasonography in the workup of patients with PD.

Materials And Methods: Data from all men undergoing duplex ultrasonography at London Health Sciences Center for PD or erectile dysfunction over a 3-year period were retrospectively reviewed.

Results: Our cohort included 722 patients with duplex ultrasound. Read More

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http://dx.doi.org/10.1016/j.urology.2018.05.014DOI Listing
August 2018
8 Reads

Patient's choice of health information and treatment modality for Peyronie's disease: a long-term assessment.

Int J Impot Res 2018 Oct 25;30(5):243-248. Epub 2018 May 25.

Department of Urology, Mayo Clinic, Rochester, MN, USA.

Despite various Peyronie's disease (PD) treatment options, the literature is sparse regarding patient preference for available therapies. Our data explore resource and treatment choices made by PD men following diagnosis. A survey was mailed to 719 randomly selected PD men evaluated at our institution from 1990-2012. Read More

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http://dx.doi.org/10.1038/s41443-018-0028-4DOI Listing
October 2018
1 Read

The relationship between penile deformity, age, psychological bother, and erectile dysfunction in a sample of men with Peyronie's Disease (PD).

Int J Impot Res 2018 Aug 25;30(4):171-178. Epub 2018 May 25.

European Institute for Sexual Health, 20534, Hamburg, Germany.

The aim of the present study was to investigate which PD specific factors (e.g., degree of penile curvature, levels of pain) cause most distress and to further explore whether there are specific subgroups of patients that report particularly high levels of psychological distress. Read More

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http://dx.doi.org/10.1038/s41443-018-0029-3DOI Listing
August 2018
1 Read

Predictors of treatment success after collagenase Clostridium histolyticum injection for Peyronie's disease: development of a nomogram from a multicentre single-arm, non-placebo controlled clinical study.

BJU Int 2018 Oct 20;122(4):680-687. Epub 2018 Jun 20.

Department of Urology, Santa Maria Annunciata Hospital, Florence, Italy.

Objective: To build a nomogram able to predict treatment success after collagenase Clostridium histolyticum (CCH) for Peyronie's disease (PD).

Materials And Methods: Between November 2016 and November 2017, we enrolled 135 patients with PD into a multicentre single-arm prospective study. All patients enrolled received CCH treatment. Read More

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http://dx.doi.org/10.1111/bju.14410DOI Listing
October 2018
25 Reads

Mondor's Disease: A Review of the Literature.

Intern Med 2018 Sep 18;57(18):2607-2612. Epub 2018 May 18.

Department of Diagnostic and Generalist Medicine, Dokkyo Medical University Hospital, Japan.

Mondor's disease (MD) is a rare disease that manifests with a palpable cord-like induration on the body surface. In general, MD is a self-limited, benign thrombophlebitis that resolves in four to eight weeks without any specific treatment. Cases of MD can be roughly categorized into three different groups based on the site of the lesion as follows: original MD of the anterolateral thoracoabdominal wall, penile MD with dorsum and dorsolateral aspects of the penis, and axillary web syndrome with mid-upper arm after axillary surgery. Read More

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http://dx.doi.org/10.2169/internalmedicine.0495-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6191595PMC
September 2018
9 Reads

Contemporary Review of Peyronie's Disease Treatment.

Curr Urol Rep 2018 May 17;19(7):51. Epub 2018 May 17.

Rush University Medical Center, Chicago, USA.

Purpose: To analyze the literature on the current treatment options for Peyronie's disease (PD).

Recent Findings: Intracavernosal injection therapy using collagenase clostridium histolyticum (CCH) has been widely adopted since its FDA approval in 2013. Based on the current evidence, it appears to be moderately efficacious for men with mild curvatures. Read More

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http://dx.doi.org/10.1007/s11934-018-0800-5DOI Listing
May 2018
2 Reads

Levels of serum trace elements in patients with Peyronie.

Aging Male 2018 May 17:1-4. Epub 2018 May 17.

b Department of Urology, Medical Faculty , Yuzuncu Yıl University , Van , Turkey.

Aim: The etiology of the disease of Peyronie is not certainly known. However, penile micro traumas are thought to be important in the pathogenesis of Peyronie's disease (PD) in genetically predisposed individuals. In this study, we aimed to determine the relationship of some trace element and heavy metals with PD. Read More

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http://dx.doi.org/10.1080/13685538.2018.1474195DOI Listing
May 2018
7 Reads

Collagenase clostridium histolyticum: a novel medical treatment for Peyronie's disease.

Minerva Urol Nefrol 2018 Aug 14;70(4):380-385. Epub 2018 May 14.

Department of Andrology, The Institute of Urology, University College London Hospitals, London, UK.

Introduction: Peyronie's disease (PD) affects up to 9% of the male population. PD causes scarring of the tunica albuginea of the penis which leads to penile deformity making sexual intercourse difficult or impossible. PD also causes significant psychological, emotional and relationship difficulties for both patient and partner. Read More

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http://dx.doi.org/10.23736/S0393-2249.18.03118-1DOI Listing
August 2018
9 Reads
0.700 Impact Factor

A Comparative Study Between 2 Different Grafts Used as Patches After Plaque Incision and Inflatable Penile Prosthesis Implantation for End-Stage Peyronie's Disease.

J Sex Med 2018 Jun 9;15(6):848-852. Epub 2018 May 9.

Urology Clinic, Città della Salute e della Scienza, University of Turin, Turin, Italy.

Background: Although many grafts have been used for plaque incision with grafting (PIG) and penile prosthesis (PP) implantation, there is no evidence that favors 1 specific graft over another.

Aim: To compare fibrin-coated collagen fleece (TachoSil; Baxter International, Deerfield, IL, USA) with porcine small intestinal submucosa (SIS; Cook Biotech, West Lafayette, IN, USA) as grafts.

Methods: From January 2007 to January 2015, 60 non-randomized consecutive patients affected by end-stage Peyronie disease underwent PIG and PP implantation (AMS 700CX; Boston Scientific, Marlborough, MA, USA). Read More

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http://dx.doi.org/10.1016/j.jsxm.2018.04.632DOI Listing
June 2018
7 Reads

Modified 16-Dot plication technique for correction of penile curvature: prevention of knot-related complications.

Authors:
Emad A Salem

Int J Impot Res 2018 Jun 8;30(3):117-121. Epub 2018 May 8.

Urology department, Zagazig University, 42 Mostafa Foad St. - Manshiet Abaza, Zagazig, Sharkia, Egypt.

Penile curvature is a common urological disease. Tunical plication for correction of penile curvature has been much popularized being simpler, adjustable to avoid overcorrection, less bleeding, and less postoperative erectile dysfunction. This study aims to assess the results of modified 16-dot plication technique for correction of congenital and acquired penile curvature and avoidance of knot-associated complications. Read More

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http://www.nature.com/articles/s41443-018-0018-6
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http://dx.doi.org/10.1038/s41443-018-0018-6DOI Listing
June 2018
7 Reads

Collagenase clostridium histolyticum for the treatment of Peyronie's disease: a prospective Italian multicentric study.

Andrology 2018 07 7;6(4):564-567. Epub 2018 May 7.

Department of Urology, Ospedale Santa Maria Annunziata, Bagno a Ripoli, Italy.

Peyronie's disease (PD) is a common condition which results in penile curvature making sexual intercourse difficult or impossible. Collagenase clostridium histolyticum (CCH) is the first licensed drug for the treatment of PD and is indicated in patients with palpable plaque and curvature deformity of at least 30° of curvature. However, only few monocentric studies are available in the current literature and this is the first national multicentric study focusing on this new treatment. Read More

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http://dx.doi.org/10.1111/andr.12497DOI Listing
July 2018
22 Reads

[Collagenase clostridium histolyticum for Peyronie's disease: A new minimally invasive and effective treatment].

Zhonghua Nan Ke Xue 2017 Sep;23(9):771-775

Department of Urology, Peking University Third Hospital, Beijing 100191, China .

The treatment of Peyronie's disease has been a challenge to urologists, as most of the current oral medications are considered hardly valid and the rest of the therapies require strict control of indications, some of which remain controversial, while the final surgical option may be associated with complications such as penile shortening or erectile dysfunction. Collagenase clostridium histolyticum has been proved to be effective in dissolving the penile cavernosal plaque and approved by the Food and Drug Administration of the USA as the first drug to be used for the treatment of Peyronie's disease. This article presents an introduction to the characteristics, safety, efficacy, and procedures of this new treatment, which may benefit urologists and the patients with Peyronie's disease. Read More

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September 2017
7 Reads

Separating the Wheat From the Chaff: An Evaluation of Readability, Quality, and Accuracy of Online Health Information for Treatment of Peyronie Disease.

Urology 2018 Aug 30;118:59-64. Epub 2018 Apr 30.

Robert Larner, M.D. College of Medicine at the University of Vermont, Burlington, VT. Electronic address:

Objective: To characterize available information about Peyronie disease online and evaluate its readability, quality, accuracy, and respective associations with HONcode certification and website category.

Methods: The search term "Peyronie disease" was queried on 3 major search engines (Google, Bing, and Yahoo) and the first 50 search results on each search engine were assessed. All websites were categorized as institutional or reference, commercial, charitable, personal or patient support, or alternative medicine, and cross-referenced with the Health on the Net (HON) Foundation. Read More

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http://dx.doi.org/10.1016/j.urology.2018.02.054DOI Listing
August 2018
5 Reads

Prospective study to evaluate the clinical outcome of intralesional interferon-α2b in the management of Peyronie's disease.

Urol Ann 2018 Apr-Jun;10(2):154-158

Department of Urology, King George's Medical University, Lucknow, Uttar Pradesh, India.

Context: Interferon (IFN)-α2b in Peyronie's disease (PD).

Aims: This study aims to evaluate clinical efficacy of the IFN-α2b in both subjective and objective manner for the treatment of PD and compared with previously used intralesional verapamil in terms of cost-benefit analysis.

Settings And Design: Prospective study. Read More

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http://dx.doi.org/10.4103/UA.UA_65_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5907323PMC
May 2018
8 Reads

Silencing Histone Deacetylase 7 Alleviates Transforming Growth Factor-β1-Induced Profibrotic Responses in Fibroblasts Derived from Peyronie's Plaque.

World J Mens Health 2018 May;36(2):139-146

National Research Center for Sexual Medicine, Inha University School of Medicine, Incheon, Korea.

Purpose: Epigenetic modifications, such as histone acetylation/deacetylation and DNA methylation, play a crucial role in the pathogenesis of inflammatory disorders and fibrotic diseases. The aim of this study was to study the differential gene expression of histone deacetylases (HDACs) in fibroblasts isolated from plaque tissue of Peyronie's disease (PD) or normal tunica albuginea (TA) and to examine the anti-fibrotic effect of small interfering RNA (siRNA)-mediated silencing of HDAC7 in fibroblasts derived from human PD plaque.

Materials And Methods: For differential gene expression study, we performed reverse-transcriptase polymerase chain reaction for HDAC isoforms (1-11) in fibroblasts isolated from PD plaque or normal TA. Read More

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http://dx.doi.org/10.5534/wjmh.170005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5924955PMC
May 2018
9 Reads

Predictive Factors of Patients' and Their Partners' Sexual Function Improvement After Collagenase Clostridium Histolyticum Injection for Peyronie's Disease: Results From a Multi-Center Single-Arm Study.

J Sex Med 2018 May;15(5):716-721

Department of Urology, Santa Maria Annunciata Hospital, Florence, Italy.

Background: Collagenase Clostridium histolyticum (CCH; Xiapex) injections represent the only licensed medical treatment for Peyronie's disease (PD).

Aim: To evaluate the efficacy and safety of CCH injections in men with stable PD, using a modified treatment protocol and to assess partners' bother improvement in a large cohort of White-European sexually active heterosexual men treated in a single tertiary-referral center.

Methods: All the 135 patients enrolled underwent a thorough assessment, which included history taking, physical examination, and pharmacologically induced artificial erection test (intra-cavernous injection) to assess the degree of penile curvature (PC) at baseline and after the completion of the treatment. Read More

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http://dx.doi.org/10.1016/j.jsxm.2018.03.084DOI Listing
May 2018
15 Reads

Inflatable Penile Prosthesis Placement, Scratch Technique and Postoperative Vacuum Therapy as a Combined Approach to Definitive Treatment of Peyronie's Disease.

J Urol 2018 Sep 17;200(3):642-647. Epub 2018 Apr 17.

Department of Urology, Coral Gables Hospital, Coral Gables, Florida.

Purpose: Peyronie's disease is a devastating condition resulting in penile malformation, erectile dysfunction, pain and emotional distress. In this prospective, 2 institution study we evaluated a multimodal surgical and mechanical combined approach to the definitive treatment of Peyronie's disease and concomitant erectile dysfunction.

Materials And Methods: A total of 145 select patients underwent endocavernous disruption of Peyronie's disease plaques via the scratch technique, followed by inflatable penile prosthesis insertion. Read More

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http://dx.doi.org/10.1016/j.juro.2018.04.060DOI Listing
September 2018
17 Reads

Penile Prosthesis Implantation in Patients With Peyronie's Disease: Results of the PROPPER Study Demonstrates a Decrease in Patient-Reported Depression.

J Sex Med 2018 May 10;15(5):786-788. Epub 2018 Apr 10.

Regional Urology, Shreveport, LA, USA.

Background: Although there is a strong correlation between erectile dysfunction and Peyronie's disease (PD), there are limited data on the efficacy and satisfaction of inflatable penile prosthesis (IPP) placement in this population.

Aim: To assess the efficacy and overall satisfaction of IPP placement in men with erectile dysfunction and concomitant PD using the Prospective Registry of Outcomes with Penile Prosthesis for Erectile Restoration (PROPPER).

Methods: Data from the PROPPER study were examined to determine patient baseline characteristics and primary and secondary etiologies before IPP treatment and included type and size of implant received, presence of corporal fibrosis, and operative time. Read More

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http://dx.doi.org/10.1016/j.jsxm.2018.02.024DOI Listing
May 2018
9 Reads

Suppression of Cavernosal Fibrosis in a Rat Model.

Sex Med Rev 2018 Oct 7;6(4):572-582. Epub 2018 Apr 7.

Department of Urology, Seoul National University College of Medicine, Seoul, Korea. Electronic address:

Introduction: Cavernosal fibrosis is an important pathologic condition leading to erectile dysfunction (ED). The etiologies of cavernosal fibrosis include aging, diabetes mellitus, castration, cavernosal nerve injury during radical prostatectomy, hypertension, and Peyronie disease.

Aims: To summarize published studies investigating suppression of cavernosal fibrosis in rat models of ED of various etiologies. Read More

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http://dx.doi.org/10.1016/j.sxmr.2018.02.007DOI Listing
October 2018
3 Reads

Penile Reconstructive Surgery in Peyronie Disease: Challenges in Restoring Normal Penis Size, Shape, and Function.

Authors:
Eric Chung

World J Mens Health 2018 Mar 29. Epub 2018 Mar 29.

Department of Urology, Princess Alexandra Hospital and University of Queensland, Brisbane, Australia.

Purpose: To provide an overview of current approaches to penile reconstructive surgery in Peyronie disease (PD), and to discuss the challenges in restoring normal penile size and function.

Methods: A systematic literature search was conducted to identify the published literature relevant to PD and penile reconstructive surgery. A summary of the published guidelines from major organisations is included in this review paper. Read More

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http://dx.doi.org/10.5534/wjmh.170056DOI Listing
March 2018
4 Reads

Objective measurements of the penile angulation are significantly different than self-estimated magnitude among patients with penile curvature.

Int Braz J Urol 2018 May-Jun;44(3):555-562

Department of Urology, University of Trieste, Trieste, Italy.

Introduction: The study was aimed to assess the presence of actual differences between the objective and the perceived magnitude of a curvature between patients affected by Peyronie's disease (PD) and congenital penile curvature (CPC).

Materials And Methods: Wee analysed a cohort of 88 consecutive patients seeking medical help for either CPC or PD. All patients were invited to provide a self-made drawing of their penis in erection in order to obtain self-provided description of the deformity. Read More

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http://dx.doi.org/10.1590/S1677-5538.IBJU.2017.0418DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5996804PMC
July 2018
3 Reads