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    1 OF 39

    Mondor's Disease: A Review of the Literature.
    Intern Med 2018 May 18. Epub 2018 May 18.
    Department of Diagnostic and Generalist Medicine, Dokkyo Medical University Hospital, Japan.
    Mondor's disease (MD) is a rare disease that manifests with a palpable cord-like induration on the body surface. In general, MD is a self-limited, benign thrombophlebitis that resolves in four to eight weeks without any specific treatment. Cases of MD can be roughly categorized into three different groups based on the site of the lesion as follows: original MD of the anterolateral thoracoabdominal wall, penile MD with dorsum and dorsolateral aspects of the penis, and axillary web syndrome with mid-upper arm after axillary surgery. Read More

    Levels of serum trace elements in patients with Peyronie.
    Aging Male 2018 May 17:1-4. Epub 2018 May 17.
    b Department of Urology, Medical Faculty , Yuzuncu Yıl University , Van , Turkey.
    Aim: The etiology of the disease of Peyronie is not certainly known. However, penile micro traumas are thought to be important in the pathogenesis of Peyronie's disease (PD) in genetically predisposed individuals. In this study, we aimed to determine the relationship of some trace element and heavy metals with PD. Read More

    A Comparative Study Between 2 Different Grafts Used as Patches After Plaque Incision and Inflatable Penile Prosthesis Implantation for End-Stage Peyronie's Disease.
    J Sex Med 2018 May 9. Epub 2018 May 9.
    Urology Clinic, Città della Salute e della Scienza, University of Turin, Turin, Italy.
    Background: Although many grafts have been used for plaque incision with grafting (PIG) and penile prosthesis (PP) implantation, there is no evidence that favors 1 specific graft over another.

    Aim: To compare fibrin-coated collagen fleece (TachoSil; Baxter International, Deerfield, IL, USA) with porcine small intestinal submucosa (SIS; Cook Biotech, West Lafayette, IN, USA) as grafts.

    Methods: From January 2007 to January 2015, 60 non-randomized consecutive patients affected by end-stage Peyronie disease underwent PIG and PP implantation (AMS 700CX; Boston Scientific, Marlborough, MA, USA). Read More

    Collagenase clostridium histolyticum for the treatment of Peyronie's disease: a prospective Italian multicentric study.
    Andrology 2018 May 7. Epub 2018 May 7.
    Department of Urology, Ospedale Santa Maria Annunziata, Bagno a Ripoli, Italy.
    Peyronie's disease (PD) is a common condition which results in penile curvature making sexual intercourse difficult or impossible. Collagenase clostridium histolyticum (CCH) is the first licensed drug for the treatment of PD and is indicated in patients with palpable plaque and curvature deformity of at least 30° of curvature. However, only few monocentric studies are available in the current literature and this is the first national multicentric study focusing on this new treatment. Read More

    [Collagenase clostridium histolyticum for Peyronie's disease: A new minimally invasive and effective treatment].
    Zhonghua Nan Ke Xue 2017 Sep;23(9):771-775
    Department of Urology, Peking University Third Hospital, Beijing 100191, China .
    The treatment of Peyronie's disease has been a challenge to urologists, as most of the current oral medications are considered hardly valid and the rest of the therapies require strict control of indications, some of which remain controversial, while the final surgical option may be associated with complications such as penile shortening or erectile dysfunction. Collagenase clostridium histolyticum has been proved to be effective in dissolving the penile cavernosal plaque and approved by the Food and Drug Administration of the USA as the first drug to be used for the treatment of Peyronie's disease. This article presents an introduction to the characteristics, safety, efficacy, and procedures of this new treatment, which may benefit urologists and the patients with Peyronie's disease. Read More

    Separating the Wheat From the Chaff: An Evaluation of Readability, Quality, and Accuracy of Online Health Information for Treatment of Peyronie's Disease.
    Urology 2018 Apr 30. Epub 2018 Apr 30.
    Robert Larner, M.D. College of Medicine at the University of Vermont. Electronic address:
    Objectives: To characterize available information about Peyronie's disease online and evaluate its readability, quality, accuracy, and respective associations with HONcode certification and website category.

    Methods: The search term "Peyronie's disease" was queried on three major search engines (Google, Bing, Yahoo) and the first 50 search results on each search engine were assessed. All websites were categorized as institutional/reference, commercial, charitable, personal/patient support, or alternative medicine, and cross-referenced with the Health on the Net (HON) Foundation. Read More

    Prospective study to evaluate the clinical outcome of intralesional interferon-α2b in the management of Peyronie's disease.
    Urol Ann 2018 Apr-Jun;10(2):154-158
    Department of Urology, King George's Medical University, Lucknow, Uttar Pradesh, India.
    Context: Interferon (IFN)-α2b in Peyronie's disease (PD).

    Aims: This study aims to evaluate clinical efficacy of the IFN-α2b in both subjective and objective manner for the treatment of PD and compared with previously used intralesional verapamil in terms of cost-benefit analysis.

    Settings And Design: Prospective study. Read More

    Silencing Histone Deacetylase 7 Alleviates Transforming Growth Factor-β1-Induced Profibrotic Responses in Fibroblasts Derived from Peyronie's Plaque.
    World J Mens Health 2018 May;36(2):139-146
    National Research Center for Sexual Medicine, Inha University School of Medicine, Incheon, Korea.
    Purpose: Epigenetic modifications, such as histone acetylation/deacetylation and DNA methylation, play a crucial role in the pathogenesis of inflammatory disorders and fibrotic diseases. The aim of this study was to study the differential gene expression of histone deacetylases (HDACs) in fibroblasts isolated from plaque tissue of Peyronie's disease (PD) or normal tunica albuginea (TA) and to examine the anti-fibrotic effect of small interfering RNA (siRNA)-mediated silencing of HDAC7 in fibroblasts derived from human PD plaque.

    Materials And Methods: For differential gene expression study, we performed reverse-transcriptase polymerase chain reaction for HDAC isoforms (1-11) in fibroblasts isolated from PD plaque or normal TA. Read More

    Predictive Factors of Patients' and Their Partners' Sexual Function Improvement After Collagenase Clostridium Histolyticum Injection for Peyronie's Disease: Results From a Multi-Center Single-Arm Study.
    J Sex Med 2018 May;15(5):716-721
    Department of Urology, Santa Maria Annunciata Hospital, Florence, Italy.
    Background: Collagenase Clostridium histolyticum (CCH; Xiapex) injections represent the only licensed medical treatment for Peyronie's disease (PD).

    Aim: To evaluate the efficacy and safety of CCH injections in men with stable PD, using a modified treatment protocol and to assess partners' bother improvement in a large cohort of White-European sexually active heterosexual men treated in a single tertiary-referral center.

    Methods: All the 135 patients enrolled underwent a thorough assessment, which included history taking, physical examination, and pharmacologically induced artificial erection test (intra-cavernous injection) to assess the degree of penile curvature (PC) at baseline and after the completion of the treatment. Read More

    Penile Prosthesis Implantation in Patients With Peyronie's Disease: Results of the PROPPER Study Demonstrates a Decrease in Patient-Reported Depression.
    J Sex Med 2018 May 10;15(5):786-788. Epub 2018 Apr 10.
    Regional Urology, Shreveport, LA, USA.
    Background: Although there is a strong correlation between erectile dysfunction and Peyronie's disease (PD), there are limited data on the efficacy and satisfaction of inflatable penile prosthesis (IPP) placement in this population.

    Aim: To assess the efficacy and overall satisfaction of IPP placement in men with erectile dysfunction and concomitant PD using the Prospective Registry of Outcomes with Penile Prosthesis for Erectile Restoration (PROPPER).

    Methods: Data from the PROPPER study were examined to determine patient baseline characteristics and primary and secondary etiologies before IPP treatment and included type and size of implant received, presence of corporal fibrosis, and operative time. Read More

    Suppression of Cavernosal Fibrosis in a Rat Model.
    Sex Med Rev 2018 Apr 6. Epub 2018 Apr 6.
    Department of Urology, Seoul National University College of Medicine, Seoul, Korea. Electronic address:
    Introduction: Cavernosal fibrosis is an important pathologic condition leading to erectile dysfunction (ED). The etiologies of cavernosal fibrosis include aging, diabetes mellitus, castration, cavernosal nerve injury during radical prostatectomy, hypertension, and Peyronie disease.

    Aims: To summarize published studies investigating suppression of cavernosal fibrosis in rat models of ED of various etiologies. Read More

    Penile Reconstructive Surgery in Peyronie Disease: Challenges in Restoring Normal Penis Size, Shape, and Function.
    World J Mens Health 2018 Mar 29. Epub 2018 Mar 29.
    Department of Urology, Princess Alexandra Hospital and University of Queensland, Brisbane, Australia.
    Purpose: To provide an overview of current approaches to penile reconstructive surgery in Peyronie disease (PD), and to discuss the challenges in restoring normal penile size and function.

    Methods: A systematic literature search was conducted to identify the published literature relevant to PD and penile reconstructive surgery. A summary of the published guidelines from major organisations is included in this review paper. Read More

    Objective measurements of the penile angulation are significantly different than self-estimated magnitude among patients with penile curvature.
    Int Braz J Urol 2018 Mar 23;44. Epub 2018 Mar 23.
    Department of Urology, University of Trieste, Trieste, Italy.
    Introduction: The study was aimed to assess the presence of actual differences between the objective and the perceived magnitude of a curvature between patients affected by Peyronie's disease (PD) and congenital penile curvature (CPC).

    Materials And Methods: Wee analysed a cohort of 88 consecutive patients seeking medical help for either CPC or PD. All patients were invited to provide a self-made drawing of their penis in erection in order to obtain self-provided description of the deformity. Read More

    A Worldwide Survey on Peyronie's Disease Surgical Practice Patterns Among Surgeons.
    J Sex Med 2018 Apr 14;15(4):568-575. Epub 2018 Mar 14.
    Division of Urology, St Joseph's Health Care, London, ON, Canada.
    Background: Despite published guidelines on Peyronie's disease (PD), there are limited data on actual surgical practice among surgeons.

    Aim: To evaluate the surgical practice patterns in PD among surgeons from different continents and members of various sexual medicine societies.

    Methods: An anonymous survey on various pre-, intra-, and postoperative aspects of PD surgical care was distributed in printed format during International Society of Sexual Medicine meetings and as an online survey to International Society of Sexual Medicine members. Read More

    A Novel Noninvasive Ultrasound Vibro-elastography Technique for Assessing Patients With Erectile Dysfunction and Peyronie Disease.
    Urology 2018 Mar 13. Epub 2018 Mar 13.
    Department of Urology, Mayo Clinic, Rochester, MN.
    Objective: To translate a novel ultrasound vibro-elastography (UVE) technique for noninvasively measuring viscoelasticity of the penis.

    Methods: A pilot study of UVE was performed in men with erectile dysfunction or Peyronie disease. Assessments were performed in triplicate on the lateral aspect of the penis (bilaterally) at 100, 150, and 200 Hz before and after erectogenic injection administration. Read More

    Safety and feasibility of platelet rich fibrin matrix injections for treatment of common urologic conditions.
    Investig Clin Urol 2018 Jan 21;59(1):61-65. Epub 2017 Dec 21.
    Department of Urology, Wake Forest Baptist Medical Center, Winston Salem, NC, USA.
    Purpose: Autologous platelet rich plasma (PRP) is used increasingly in a variety of settings. PRP injections have been used for decades to improve angiogenesis and wound healing. They have also been offered commercially in urology with little to no data on safety or efficacy. Read More

    The PICS Technique: A Novel Approach for Residual Curvature Correction During Penile Prosthesis Implantation in Patients With Severe Peyronie's Disease Using the Collagen Fleece TachoSil.
    J Sex Med 2018 Mar 8;15(3):416-421. Epub 2018 Jan 8.
    Department of Urology and Pediatric Urology, Julius Maximilians University of Würzburg, Würzburg, Germany. Electronic address:
    Background: Correction of residual curvature during inflatable penile prosthesis (IPP) implantation in patients with Peyronie's disease (PD) by plaque incision and grafting is a common approach.

    Aim: To present a novel technique for residual curvature correction during IPP implantation using collagen fleece (TachoSil, Baxter Healthcare Corp, Deerfield, IL, USA).

    Methods: After the IPP (Titan Touch, Coloplast, Minneapolis, MN, USA) is placed, the implant is inflated maximally. Read More

    The Multiple-Slit Technique (MUST) for Penile Length and Girth Restoration.
    J Sex Med 2018 Feb 21;15(2):261-269. Epub 2017 Dec 21.
    Private Practice, Vienna, Austria. Electronic address:
    Background: Patients with severe erectile dysfunction (ED) and penile size issues, especially seen in Peyronie's disease (PD), are candidates for more invasive penile prosthesis insertion techniques that aim for penile length and girth reconstruction.

    Aim: To present the feasibility and safety of penile length and girth restoration based on the so-called multiple-slit technique (MUST) for patients with severe ED and significant penile shortening with or without PD.

    Methods: From July 2013 through January 2016, 138 patients underwent the MUST. Read More

    Grafts for Peyronie's disease: a comprehensive review.
    Andrology 2018 Jan 20;6(1):117-126. Epub 2017 Dec 20.
    Department of Urology, 12 de Octubre University Hospital, Madrid, Spain.
    The difficulty implicit in combining all the characteristics that an ideal patch to treat Peyronie's disease with a lengthening procedure should have, together with the challenges of comparing results from different series, means that the ideal patch has yet to be determined. Our objective with this review was to determine whether any given patch type is preferable to the others based on the evaluation of the results of published studies. A systematic search of the literature was conducted from PubMed until December 2016. Read More

    [Cavernous metastasis from blader tumor].
    Pan Afr Med J 2017 21;28:60. Epub 2017 Sep 21.
    Université Mohammed 5, Faculté de Médecine et de Pharmacie de Rabat, Hopital Ibn Sina, Service d'Urologie B, Maroc.
    The incidence of cavernous metastases after radical treatment for bladder tumor is exceptional and is approximately 1%. The mean time between surgery and the occurrence of metastases is 8 months. In some cases they occur after 10 years. Read More

    Compounding Opportunities in Urology.
    Int J Pharm Compd 2017 Sep-Oct;21(5):358-362
    Professional Compounding Centers of America, Houston, Texas.
    There are a lot of options that pharmacists, including compounding pharmacists, can offer urologists to assist their patients. Compounding pharmacists are in a great position to offer unique, effective preparations for many of the conditions urologists treat on a daily basis. It would be well worth the time to learn a little about the conditions these specialists treat and become familiar with what you can offer. Read More

    Inhibition of penile tunica albuginea myofibroblasts activity by adipose-derived stem cells.
    Exp Ther Med 2017 Nov 21;14(5):5149-5156. Epub 2017 Sep 21.
    Department of Andrology, Drum Tower Hospital, Affiliated to School of Medicine, Nanjing University, Nanjing, Jiangsu 210008, P.R. China.
    The activation of tunica albuginea myofibroblasts (MFs) serves an essential role in Peyronie's disease (PD). Increasing evidence has reported that adipose tissue-derived stem cells (ADSCs) have been demonstrated to attenuate the symptoms of PD in animal models. However, the mechanisms of the antifibrotic effects of ADSCs in PD remain to be fully elucidated. Read More

    Surgical correction of Peyronie's disease via tunica albuginea plication: long-term follow-up.
    Andrology 2018 Jan 1;6(1):47-52. Epub 2017 Dec 1.
    Department of Urology, Humanitas Mater Domini, Castellanza, Italy.
    Peyronie's disease (PD) is an acquired connective tissue disorder of the tunica albuginea with fibrosis and inflammation that lead to palpable plaques formation, penile curvature, and pain during erection. Patients report negative effects on main domains such as physical appearance and self-image, sexual function, and performance. The aim of this study was to evaluate plication of the albuginea outcomes after a long-term follow-up period. Read More

    Defining a glycated haemoglobin (HbA1c) level that predicts increased risk of penile implant infection.
    BJU Int 2018 02 1;121(2):293-300. Epub 2017 Dec 1.
    Sexual and Reproductive Medicine Program, Urology Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
    Objectives: To re-evaluate the role of diabetes mellitus (DM) as a risk factor for penile implant infection by exploring the association between glycated haemoglobin (HbA1c) levels and penile implant infection rates and to define a threshold value that predicts implant infection.

    Patients And Methods: We conducted a multicentre prospective study including all patients undergoing penile implant surgery between 2009 and 2015. Preoperative, perioperative and postoperative management were identical for the entire cohort. Read More

    Penile metastasis from rectal adenocarcinoma: a case report.
    BMC Res Notes 2017 Nov 6;10(1):564. Epub 2017 Nov 6.
    Department of Pathology, Hassan II University Hospital, Fès, Morocco.
    Background: Despite its rich vasculature, the penis is rarely involved by metastasis. Since the first description of penile metastasis in 1870, fewer than 500 cases have been reported in the literature. The pelvic organs are the main source of primary tumors that metastasize to the penis. Read More

    Complications of penile self-injections: investigation of 680 patients with complications following penile self-injections with mineral oil.
    World J Urol 2018 Jan 28;36(1):135-143. Epub 2017 Oct 28.
    Urological Research Center (URC), Department of Urology, Lillebaelt Hospital, Fredericia, Denmark.
    Objective: Penile implants and injection of foreign materials have been described in texts like Kama Sutra for more than 1500 years, and are still being practiced around the world. The extent of this practice is unknown, and the documentation available today only scratches the surface. This study investigates and documents the complications after penile self-injections at the Mae Tao Clinic. Read More

    [Diagnostic value of high-field MRI for Peyronie's disease].
    Zhonghua Nan Ke Xue 2016 Sep;22(9):787-791
    Department of Ultrasonography, The First Hospital Affiliated to Sun Yat-sen University, Guangzhou, Guangdong 510080, China.
    Objective: To analyze the MRI manifestations of Peyronie's disease and investigate the value of high-field MRI in the diagnosis of the disease.

    Methods: Using a small surface coil, we performed 3.0 Tesla MRI for 14 patients with clinically diagnosed Peyronie's disease. Read More

    [Buccal mucosa transplant the concept of ideal graft in surgical management of peyronies disease].
    Urologiia 2017 Sep(4):68-72
    N.I. Pirogov RNRMU of Minzdrav of Russia, Moscow, Russia.
    Introduction: Surgical techniques in managing Peyronies disease include plication corporoplasty, plaque incision, grafting and penile prosthesis implantation. The question of an ideal transplant for corporoplasty remains open.

    Aim: To evaluate the effectiveness of the substitution corporoplasty using buccal mucosa transplant (BMT) in treating Peyronies disease. Read More

    Successful Treatment of Residual Curvature in Peyronie Disease in Men Previously Treated With Intralesional Collagenase Clostridium Histolyticum.
    Urology 2017 Dec 5;110:110-113. Epub 2017 Sep 5.
    Department of Urology, Tulane University School of Medicine, New Orleans, LA. Electronic address:
    Objective: To determine the success and feasibility of surgically correcting residual curvature after intralesional collagenase clostridium histolyticum (CCH) for the treatment of Peyronie disease (PD).

    Methods: We performed a retrospective analysis of patients who had intralesional CCH treatment for PD and who subsequently underwent penile plication (PP), plaque incision and grafting (PIG), or inflatable penile prosthesis (IPP) placement.

    Results: Ten men who underwent PP, PIG, or IPP for the treatment of residual curvature after intralesional CCH were identified. Read More

    Collagenase Clostridium Histolyticum in the Treatment of Peyronie's Disease: Review of a Minimally Invasive Treatment Option.
    World J Mens Health 2017 Dec 6;35(3):134-145. Epub 2017 Sep 6.
    Department of Urology, Tulane University School of Medicine, New Orleans, LA, USA.
    Peyronie's disease (PD) is an inflammatory disorder characterized by an abnormal collagen deposition in the tunica albuginea of the penis, leading to fibrous and non-compliant plaques that can impede normal erection. Although pharmacological treatments are available, only intralesional injection therapy and surgical reconstruction have demonstrated tangible clinical efficacy in the management of this condition. Intralesional injection of collagenase clostridium histolyticum (CCH) has come to the forefront of minimally invasive treatment of PD. Read More

    Collagenase Clostridium histolyticum in the Treatment of Peyronie's Disease-A Review of the Literature and a New Modified Protocol.
    Sex Med Rev 2017 Oct 2;5(4):529-535. Epub 2017 Sep 2.
    Andrology Department, The Institute of Urology and University College London Hospital, London, UK.
    Introduction: Peyronie's disease (PD) is a common condition that results in penile deformity, which makes sexual intercourse difficult or impossible, and causes psychological, emotional, and relationship difficulties for the man affected and his partner. Collagenase Clostridium histolyticum (CCH; Xiapex, Xiaflex) is the first licensed non-surgical treatment option for PD. The safety and efficacy have been demonstrated in two large phase III randomized controlled trials (IMPRESS I and IMPRESS II). Read More

    Dupuytren-Like Contracture of the Foot: Ledderhose Disease.
    Surg J (N Y) 2016 Jul 21;2(3):e102-e104. Epub 2016 Sep 21.
    Department of Plastic, Reconstructive, and Aesthetic Surgery, Selcuk University Medical Faculty, Konya, Turkey.
     Plantar fibromatosis is a rare hyperproliferative disease of plantar aponeurosis and is also called Ledderhose disease. Case properties and treatment are discussed in this report.  A 30-year-old man presented with painful bilateral plantar nodules. Read More

    Penile Doppler ultrasonography revisited.
    Ultrasonography 2018 Jan 10;37(1):16-24. Epub 2017 Jun 10.
    Department of Urology and Urological Science Institute, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
    Penile Doppler ultrasonography is a high-performing, noninvasive or minimally-invasive imaging modality that allows the depiction of the normal anatomy and macroscopic pathologic changes in real time. Moreover, functional changes in penile blood flow, as seen in erectile dysfunction (ED), can be analyzed using color Doppler ultrasonography (CDUS). This review article describes the normal sonographic anatomy of the penis, the sonographic technique for evaluating ED, the normal phases of erection, and the various causes of ED. Read More

    An unanswered question in pediatric urology: the post pubertal persistence of prepubertal congenital penile curvature correction by tunical plication.
    Int Braz J Urol 2017 Sep-Oct;43(5):925-931
    Department of Urology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
    Objective: The aim of this study is to analyze post pubertal results of pre pubertal tunica albuginea plication with non-absorbable sutures in the correction of CPC.

    Materials And Methods: The files of patients who underwent tunica albuginea plication without incision (dorsal/lateral) were retrospectively reviewed. Patients younger than 13 years of age at the time of operation and older than 14 years of age in November 2015 were included. Read More

    Extracellular matrix alterations in the Peyronie's disease.
    J Adv Res 2017 Jul 15;8(4):455-461. Epub 2017 Jun 15.
    Biochemistry Departament, Faculdade de Medicina do ABC, Santo André 09060-650, Brazil.
    Peyronie's disease is characterized by fibrous plaque formation of the tunica albuginea, causing penile deformity and fertility problems. The aim of the present study was to investigate alterations in the extracellular matrix in Peyronie's disease. The study used tissues collected by surgical procedure from individuals that presented a well-established disease, while control samples were obtained by biopsies of fresh cadavers. Read More

    Evaluation of intralesional injection of hyaluronic acid compared with verapamil in Peyronie's disease: preliminary results from a prospective, double-blinded, randomized study.
    Andrology 2017 07;5(4):771-775
    Urology Section, Department of Surgery, University of Catania, Catania, Italy.
    Several intralesional therapeutic protocols have been proposed for the treatment of Peyronie's disease. Among all, hyaluronic acid (HA) and verapamil have been differently tested. We aimed to evaluate the efficacy of intralesional verapamil (ILVI) compared with intralesional HA in patients with early onset of Peyronie's disease (PD). Read More

    Penile Plication With or Without Degloving of the Penis Results in Similar Outcomes.
    Sex Med 2017 Sep 13;5(3):e142-e147. Epub 2017 Jul 13.
    Department of Urology, Uludag University, School of Medicine, Bursa, Turkey.
    Background: Penile plication techniques with or without degloving offer a minimally invasive option for the treatment of penile curvature.

    Aim: To review the outcomes of penile plication surgery and patient satisfaction with and without degloving of the penis.

    Methods: We conducted a retrospective analysis of 52 patients who underwent penile plication for the treatment of Peyronie disease or congenital penile curvature. Read More

    Prevalence of Peyronie's Disease-Like Symptoms in Men Presenting With Dupuytren Contractures.
    Sex Med 2017 Sep 1;5(3):e135-e141. Epub 2017 Jul 1.
    Department of Orthopaedic Surgery, University of California-Davis, Sacramento, CA, USA.
    Introduction: Peyronie's disease (PD) and Dupuytren contractures (DC) are often comorbid and are believed to have a similar underlying pathophysiologic mechanism.

    Aim: To investigate the prevalence of PD-like symptoms (PDLS) in men with DC.

    Methods: From October 2013 to December 2016, men who were seen and evaluated for DC were offered the opportunity to participate in an anonymous survey. Read More

    Safety and effectiveness of collagenase clostridium histolyticum in the treatment of Peyronie's disease using a new modified shortened protocol.
    BJU Int 2017 11 14;120(5):717-723. Epub 2017 Jul 14.
    Andrology Department, University College London Hospital and The Institute of Urology London and St Peter's Andrology Centre, London, UK.
    Objectives: To evaluate the efficacy and safety of collagenase clostridium histolyticum (CCH; Xiapex , Xiaflex ) in the treatment of Peyronie's disease (PD) using a new modified treatment protocol that aims at reducing the number of injections needed and reducing patient visits, thus reducing the duration and cost of treatment.

    Patients And Methods: A prospective study of 53 patients with PD who had treatment with CCH at a single centre using a new modified protocol. The angle of curvature assessment after an intracavernosal injection of prostaglandin E1, the International Index of Erectile Function (IIEF) and Peyronie's Disease Questionnaire (PDQ) were completed at baseline and at week 12 (4 weeks after the last injection). Read More

    Association of the modified frailty index with adverse outcomes after penile prosthesis implantation.
    Aging Male 2017 Jun 28;20(2):119-124. Epub 2017 Feb 28.
    b Division of Urology , Department of Surgery, Faculty of Medicine, King Saud University , Riyadh , Saudi Arabia , and.
    Objectives: To investigate frailty as a predictor of surgical outcome in elderly patients undergoing penile prosthesis implantation.

    Material And Methods: A total of 54 elderly patients, above 60 years of age, underwent penile prosthesis implantation between 2012 and 2014. Their data were collected and retrospectively analyzed. Read More

    Factors Associated With Erectile Dysfunction and the Peyronie's Disease Questionnaire in Patients With Peyronie Disease.
    Urology 2017 Sep 26;107:155-160. Epub 2017 May 26.
    Tulane University Health Sciences Center, New Orleans, LA.
    Objective: To elucidate patient characteristics that impact symptom-related bother and erectile function in patients with Peyronie disease (PD).

    Methods: A post hoc analysis used data from patients with PD (ie, had PD symptoms ≥12 months and penile curvature deformity of 30-90 degrees) who received ≥1 injection of study medication in 2 phase 3 trials of collagenase clostridium histolyticum (Investigation for Maximal Peyronie's Reduction Efficacy and Safety Study I [n = 417] and Investigation for Maximal Peyronie's Reduction Efficacy and Safety Study II [n = 415]). The Covariance Analysis of Linear Structural Equations procedure was used to estimate the potential relationship of specified variables on the level of distress and erectile dysfunction associated with PD as measured by the Peyronie's Disease Questionnaire and the International Index of Erectile Function, erectile function domain. Read More

    A new technique, combined plication-incision (CPI), for correction of penile curvature.
    Int Braz J Urol 2018 Jan-Feb;44(1):180-187
    Department of Andrology, Faculty of Medicine, Cairo University, Cairo, Egypt.
    Introduction: Penile curvature (PC) can be surgically corrected by either corporoplasty or plication techniques. These techniques can be complicated by post-operative: penile shortening, recurrent PC, painful/palpable suture knots and erectile dysfunction.

    Objective: To avoid the complications of corporoplasty and plication techniques using a new technique: combined plication-incision (CPI). Read More

    Penile ossification: A reconstructive challenge.
    Rev Urol 2017 ;19(1):64-67
    Department of Urology, University of Texas Southwestern Medical CenterDallas, TX.
    Penile ossification is a rare condition that occurs most commonly in acquired cases of penile deformity. We report the case of a 43-year-old man with Peyronie disease who was incidentally found to have significant ossified tissue in his penile corpora during complex placement of an inflatable penile prosthesis (IPP). His clinical course was later complicated by impending distal extrusion of his IPP laterally, necessitating corporoplasty. Read More

    [Penile Tuberculosis : A Case Report].
    Hinyokika Kiyo 2017 Apr;63(4):163-167
    The Department of Infection Control Team, Osaka Police Hospital.
    A 66-year-old man presented with a chief complaint of glans penis pain, induration, and discharge of pus. He was prescribed a course of antibiotics, but the condition persisted despite treatment. Thus, we differrentially diagnosed the patient with penile tuberculosis and pyoderma gangrenosum, and performed a biopsy of the penis. Read More

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