277 results match your criteria Peyronie Disease


Simvastatin and the Rho-kinase inhibitor Y-27632 prevent myofibroblast transformation in Peyronie's disease-derived fibroblasts via inhibition of YAP/TAZ nuclear translocation.

BJU Int 2018 Dec 9. Epub 2018 Dec 9.

Laboratory of Experimental Urology, Department of Development and Regeneration, KU, Leuven, Belgium.

Objectives: To uncover the anti-myofibroblast (MFB) properties of Rho-kinase inhibitor (compound Y-27632) and simvastatin in an in vitro model of Peyronie's disease (PD). PD is a sexual debilitating disease caused by an irreversible fibrotic plaque in the penile tunica albuginea (TA). Treatment is limited to surgically restoring anatomical shape. Read More

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December 2018

Prevalence of penile curvature: a population-based cross-sectional study in metropolitan and rural cities in Australia.

BJU Int 2018 Nov;122 Suppl 5:42-49

Department of Urology, Western Health, Melbourne, Vic., Australia.

Objective: To evaluate the prevalence of penile curvature and health-seeking behaviour in Australian men.

Patients And Methods: A population-based, cross-sectional anonymous web-based survey was designed, and men aged between 35 and 75 years in major and rural metropolitan cities across Australia were invited to participate. Respondents were screened for self-reported symptoms of penile curvature and their impact on various psychosexual domains. Read More

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November 2018
1 Read
3.530 Impact Factor

Long-term outcome after grafting with small intestinal submucosa and collagen fleece in patients with Peyronie´s disease: a matched pair analysis.

Int J Impot Res 2018 Oct 22. Epub 2018 Oct 22.

Department of Urology and Pediatric Urology, Julius-Maximilians-University of Würzburg, Würzburg, Germany.

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October 2018

Antifibrotic Synergy Between Phosphodiesterase Type 5 Inhibitors and Selective Oestrogen Receptor Modulators in Peyronie's Disease Models.

Eur Urol 2018 Oct 18. Epub 2018 Oct 18.

Anglia Ruskin University, Chelmsford, UK. Electronic address:

Background: Peyronie's disease (PD) is a fibrotic disorder of the penile tunica albuginea, characterised by the formation of a localised fibrous plaque that can lead to deformity and erectile dysfunction. Nonsurgical therapeutic options for PD are limited in efficacy and safety. Myofibroblasts are key cells in the pathogenesis of PD, and inhibition of myofibroblast transformation has been suggested as a therapeutic option. Read More

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October 2018
5 Reads

The comparison of an acellular matrix graft with an autologous venous graft in the surgical treatment of Peyronie's disease.

Andrologia 2018 Oct 9:e13168. Epub 2018 Oct 9.

Department of Urology, Ankara Ataturk Education and Research Hospital, Ankara, Turkey.

The aim of this study was to evaluate acellular porcine pericardium (APP) and compared the results with those obtained from venous grafts in the surgical management of Peyronie's disease (PD). An APP (Group 1) and an autologous saphenous vein graft (Group 2) were used in 27 and 26 patients, respectively for Peyronie's correction. The patients' age, body mass index (BMI), operation time, duration of follow-up, preoperative and postoperative IIEF-5 scores, plaque size and loss of sensation were evaluated in both groups. Read More

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October 2018
3 Reads

Clinical Efficacy of Injection and Mechanical Therapy for Peyronie's Disease: A Systematic Review of the Literature.

Eur Urol 2018 Dec 17;74(6):767-781. Epub 2018 Sep 17.

Department of Urology, University Hospitals Leuven, Leuven, Belgium.

Context: Conservative therapies for Peyronie's disease (PD) aim to treat early-stage disease by improving clinical outcomes such as penile curvature, penile length erectile dysfunction, and pain.

Objective: To summarise the available evidence regarding injection and mechanical therapies for PD treatment.

Evidence Acquisition: An extensive search of Medline, Embase, and Scopus databases retrieved English-language articles up to 15 May 2018. Read More

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December 2018
1 Read

Plication for Severe Peyronie's Deformities Has Similar Long-Term Outcomes to Milder Cases.

J Sex Med 2018 Oct 15;15(10):1498-1505. Epub 2018 Sep 15.

Department of Urology, University of Texas Southwestern Medical Center, Dallas, TX, USA. Electronic address:

Introduction: Penile plication (PP) for Peyronie's disease (PD) is an established treatment option for mild to moderate curvature, but scant data exist regarding its utility in severe deformities.

Aim: To evaluate long-term outcomes among men undergoing PP for PD, comparing severe to mild/moderate penile deformities.

Methods: We performed a retrospective review of patients who underwent PP for PD between 2009 and 2017. Read More

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October 2018
8 Reads

[Low-intensity extracorporeal shockwave therapy for Peyronie's disease: A preliminary study of 32 cases].

Zhonghua Nan Ke Xue 2018 Apr;24(4):340-344

Department of Andrology, Henan Provincial People's Hospital, Zhengzhou, Henan 450000, China.

Objective: To investigate the clinical effect of low-intensity extracorporeal shockwave therapy (LI-ESWT) on Peyronie's disease.

Methods: From October 2016 to December 2017, we treated 32 cases of Peyronie's disease by LI-ESWT, with the therapeutic index of 0.09 mJ/mm2 and a pulse frequency of 120 beats/min. Read More

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April 2018
7 Reads

[Plaque excision plus autologous perididymal patch grafting for Peyronie's disease].

Zhonghua Nan Ke Xue 2018 Janurary;24(1):55-58

Department of Urology, Xuzhou Hospital Affiliated to Southeast University School of Medicine, Xuzhou, Jiangsu 221009, China.

Objective: To investigate the clinical effect of plaque excision plus autologous perididymal patch grafting in the treatment of Peyronie's disease.

Methods: This study included 10 patients with Peyronie's disease received in our Department of Urology between January 2013 and December 2015, who had failed to respond to over 12 months of expectant drug therapy and remained stable for more than 6 months, none able to perform sexual intercourse due to penile curvature (>60°). All the patients underwent plaque excision plus autologous perididymal patch grafting. Read More

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November 2018
3 Reads

Penile lengthening with porcine small intestinal submucosa grafting in Peyronie's disease treatment: long-term surgical outcomes, patients' satisfaction and dissatisfaction predictors.

Andrology 2018 Aug 3. Epub 2018 Aug 3.

Nuno Tomada Urologia e Cirurgia Reconstrutiva, Porto, Portugal.

Background: Peyronie's Disease (PD) is an acquired connective tissue disorder that often leads to penile curvature (PC) and sexual dysfunction. Penile lengthening procedures (PLP) with four-layered porcine small intestinal submucosa graft (Surgisis ES; Cook) have been widely used in patients with severe PC when erectile function is preserved. However, complications such as erectile dysfunction (ED) may limit treatment satisfaction. Read More

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August 2018
10 Reads

[Senescent cells: a target in osteo-articular diseases].

Med Sci (Paris) 2018 Jun-Jul;34(6-7):547-553. Epub 2018 Jul 31.

IRMB (institut de médecine régénératrice et de biothérapie de Montpellier), Inserm U1183, Univ Montpellier, 80, avenue Augustin Fliche, 34298 Montpellier, France.

Our societies are facing with the emergence of an exponential number of patients with age-related degenerative chronic diseases such as osteoarthritis or osteoporosis. The "better" aging will thus be at the center of the next medical challenges in order to delay the loss of independence of the elderly and reduce costs of our health services. Over the last 5 years, based on innovative mouse models or in vitro studies, several research teams have demonstrated that many age-related degenerative diseases have in common a deleterious accumulation of so-called senescent cells in their respective deficient tissues. Read More

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The Use of Stromal Vascular Fraction in the Treatment of Male Sexual Dysfunction: A Review of Preclinical and Clinical Studies.

Sex Med Rev 2018 Jun 27. Epub 2018 Jun 27.

Tulane University School of Medicine, Department of Urology, New Orleans, LA, USA. Electronic address:

Introduction: Stem cell therapy using stromal vascular fraction (SVF) is a promising treatment modality. SVF is comprised of a mixture of adipose-derived stem cells, endothelial precursor cells, and immune modulatory cells that act synergistically to facilitate angiogenesis and epithelial cell differentiation. This makes SVF an attractive option for men's sexual disorders that require reconstitution of vasculature and endothelial lining, namely erectile dysfunction (ED) and Peyronie's disease (PD). Read More

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June 2018
10 Reads

Biomechanical Comparison of Inflatable Penile Implants: A Cadaveric Pilot Study.

J Sex Med 2018 Jul;15(7):1034-1040

Advanced Urology, Atlanta, GA, USA.

Background: Throughout the last decade there has been a growing interest in the biomechanical differences between inflatable penile prostheses (IPPs) and their significance with regard to the patient experience.

Aim: To present our findings assessing the biomechanical properties of IPPs with and without rear tip extenders (RTEs).

Methods: This is a biomechanical study of the 3 most commonly used IPPs (AMS CX, AMS LGX, and Coloplast Titan) as assessed by column compression, modified cantilever deflection, and 3-point bending methods. Read More

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July 2018
18 Reads

Reduction in Peyronie's-like plaque size using a vacuum erection device in a rat model of Peyronie's disease via the TGF-β/SMAD signalling pathway.

Andrologia 2018 May 28:e13051. Epub 2018 May 28.

Andrology Laboratory, West China Hospital, Sichuan University, Chengdu, China.

Peyronie's disease (PD) is a fibrotic disorder of the tunica albuginea (TA). This study aimed to determine the therapeutic effects of a vacuum erection device (VED) in an animal model of PD and explore the possible mechanisms. Twenty-seven male Sprague-Dawley rats were used. Read More

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May 2018
5 Reads

Surgical Outcomes of Plaque Excision and Grafting and Supplemental Tunica Albuginea Plication for Treatment of Peyronie's Disease With Severe Compound Curvature.

J Sex Med 2018 Jul 22;15(7):1021-1029. Epub 2018 May 22.

Department of Urology, Rush University Medical Center, Chicago, IL, USA.

Background: There are limited data in the literature that describe the management of Peyronie's disease (PD) with severe compound curvature, which often requires additional straightening procedures after plaque excision and grafting (PEG) to achieve functional penile straightening (<20 degrees).

Aim: This study highlights the clinical distinction and our experience with men with PD and severe compound curvature treated with PEG and supplemental tunica albuginea plication (TAP).

Methods: We performed a retrospective chart review of patients with PD and acute angulation who underwent PEG (group 1) and patients with compound curvature who underwent PEG with TAP (group 2) between 2007 and 2016. Read More

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July 2018
3 Reads

Predictors of treatment success after collagenase Clostridium histolyticum injection for Peyronie's disease: development of a nomogram from a multicentre single-arm, non-placebo controlled clinical study.

BJU Int 2018 Oct 20;122(4):680-687. Epub 2018 Jun 20.

Department of Urology, Santa Maria Annunciata Hospital, Florence, Italy.

Objective: To build a nomogram able to predict treatment success after collagenase Clostridium histolyticum (CCH) for Peyronie's disease (PD).

Materials And Methods: Between November 2016 and November 2017, we enrolled 135 patients with PD into a multicentre single-arm prospective study. All patients enrolled received CCH treatment. Read More

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October 2018
14 Reads

Levels of serum trace elements in patients with Peyronie.

Aging Male 2018 May 17:1-4. Epub 2018 May 17.

b Department of Urology, Medical Faculty , Yuzuncu Yıl University , Van , Turkey.

Aim: The etiology of the disease of Peyronie is not certainly known. However, penile micro traumas are thought to be important in the pathogenesis of Peyronie's disease (PD) in genetically predisposed individuals. In this study, we aimed to determine the relationship of some trace element and heavy metals with PD. Read More

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May 2018
7 Reads

A Comparative Study Between 2 Different Grafts Used as Patches After Plaque Incision and Inflatable Penile Prosthesis Implantation for End-Stage Peyronie's Disease.

J Sex Med 2018 Jun 9;15(6):848-852. Epub 2018 May 9.

Urology Clinic, Città della Salute e della Scienza, University of Turin, Turin, Italy.

Background: Although many grafts have been used for plaque incision with grafting (PIG) and penile prosthesis (PP) implantation, there is no evidence that favors 1 specific graft over another.

Aim: To compare fibrin-coated collagen fleece (TachoSil; Baxter International, Deerfield, IL, USA) with porcine small intestinal submucosa (SIS; Cook Biotech, West Lafayette, IN, USA) as grafts.

Methods: From January 2007 to January 2015, 60 non-randomized consecutive patients affected by end-stage Peyronie disease underwent PIG and PP implantation (AMS 700CX; Boston Scientific, Marlborough, MA, USA). Read More

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June 2018
5 Reads

Collagenase clostridium histolyticum for the treatment of Peyronie's disease: a prospective Italian multicentric study.

Andrology 2018 Jul 7;6(4):564-567. Epub 2018 May 7.

Department of Urology, Ospedale Santa Maria Annunziata, Bagno a Ripoli, Italy.

Peyronie's disease (PD) is a common condition which results in penile curvature making sexual intercourse difficult or impossible. Collagenase clostridium histolyticum (CCH) is the first licensed drug for the treatment of PD and is indicated in patients with palpable plaque and curvature deformity of at least 30° of curvature. However, only few monocentric studies are available in the current literature and this is the first national multicentric study focusing on this new treatment. Read More

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July 2018
17 Reads

[Collagenase clostridium histolyticum for Peyronie's disease: A new minimally invasive and effective treatment].

Zhonghua Nan Ke Xue 2017 Sep;23(9):771-775

Department of Urology, Peking University Third Hospital, Beijing 100191, China .

The treatment of Peyronie's disease has been a challenge to urologists, as most of the current oral medications are considered hardly valid and the rest of the therapies require strict control of indications, some of which remain controversial, while the final surgical option may be associated with complications such as penile shortening or erectile dysfunction. Collagenase clostridium histolyticum has been proved to be effective in dissolving the penile cavernosal plaque and approved by the Food and Drug Administration of the USA as the first drug to be used for the treatment of Peyronie's disease. This article presents an introduction to the characteristics, safety, efficacy, and procedures of this new treatment, which may benefit urologists and the patients with Peyronie's disease. Read More

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September 2017
2 Reads

Separating the Wheat From the Chaff: An Evaluation of Readability, Quality, and Accuracy of Online Health Information for Treatment of Peyronie Disease.

Urology 2018 Aug 30;118:59-64. Epub 2018 Apr 30.

Robert Larner, M.D. College of Medicine at the University of Vermont, Burlington, VT. Electronic address:

Objective: To characterize available information about Peyronie disease online and evaluate its readability, quality, accuracy, and respective associations with HONcode certification and website category.

Methods: The search term "Peyronie disease" was queried on 3 major search engines (Google, Bing, and Yahoo) and the first 50 search results on each search engine were assessed. All websites were categorized as institutional or reference, commercial, charitable, personal or patient support, or alternative medicine, and cross-referenced with the Health on the Net (HON) Foundation. Read More

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August 2018
4 Reads

Prospective study to evaluate the clinical outcome of intralesional interferon-α2b in the management of Peyronie's disease.

Urol Ann 2018 Apr-Jun;10(2):154-158

Department of Urology, King George's Medical University, Lucknow, Uttar Pradesh, India.

Context: Interferon (IFN)-α2b in Peyronie's disease (PD).

Aims: This study aims to evaluate clinical efficacy of the IFN-α2b in both subjective and objective manner for the treatment of PD and compared with previously used intralesional verapamil in terms of cost-benefit analysis.

Settings And Design: Prospective study. Read More

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May 2018
7 Reads

Predictive Factors of Patients' and Their Partners' Sexual Function Improvement After Collagenase Clostridium Histolyticum Injection for Peyronie's Disease: Results From a Multi-Center Single-Arm Study.

J Sex Med 2018 May;15(5):716-721

Department of Urology, Santa Maria Annunciata Hospital, Florence, Italy.

Background: Collagenase Clostridium histolyticum (CCH; Xiapex) injections represent the only licensed medical treatment for Peyronie's disease (PD).

Aim: To evaluate the efficacy and safety of CCH injections in men with stable PD, using a modified treatment protocol and to assess partners' bother improvement in a large cohort of White-European sexually active heterosexual men treated in a single tertiary-referral center.

Methods: All the 135 patients enrolled underwent a thorough assessment, which included history taking, physical examination, and pharmacologically induced artificial erection test (intra-cavernous injection) to assess the degree of penile curvature (PC) at baseline and after the completion of the treatment. Read More

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May 2018
9 Reads

Penile Prosthesis Implantation in Patients With Peyronie's Disease: Results of the PROPPER Study Demonstrates a Decrease in Patient-Reported Depression.

J Sex Med 2018 May 10;15(5):786-788. Epub 2018 Apr 10.

Regional Urology, Shreveport, LA, USA.

Background: Although there is a strong correlation between erectile dysfunction and Peyronie's disease (PD), there are limited data on the efficacy and satisfaction of inflatable penile prosthesis (IPP) placement in this population.

Aim: To assess the efficacy and overall satisfaction of IPP placement in men with erectile dysfunction and concomitant PD using the Prospective Registry of Outcomes with Penile Prosthesis for Erectile Restoration (PROPPER).

Methods: Data from the PROPPER study were examined to determine patient baseline characteristics and primary and secondary etiologies before IPP treatment and included type and size of implant received, presence of corporal fibrosis, and operative time. Read More

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May 2018
8 Reads

Suppression of Cavernosal Fibrosis in a Rat Model.

Sex Med Rev 2018 Oct 7;6(4):572-582. Epub 2018 Apr 7.

Department of Urology, Seoul National University College of Medicine, Seoul, Korea. Electronic address:

Introduction: Cavernosal fibrosis is an important pathologic condition leading to erectile dysfunction (ED). The etiologies of cavernosal fibrosis include aging, diabetes mellitus, castration, cavernosal nerve injury during radical prostatectomy, hypertension, and Peyronie disease.

Aims: To summarize published studies investigating suppression of cavernosal fibrosis in rat models of ED of various etiologies. Read More

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October 2018
2 Reads

Penile Reconstructive Surgery in Peyronie Disease: Challenges in Restoring Normal Penis Size, Shape, and Function.

Authors:
Eric Chung

World J Mens Health 2018 Mar 29. Epub 2018 Mar 29.

Department of Urology, Princess Alexandra Hospital and University of Queensland, Brisbane, Australia.

Purpose: To provide an overview of current approaches to penile reconstructive surgery in Peyronie disease (PD), and to discuss the challenges in restoring normal penile size and function.

Methods: A systematic literature search was conducted to identify the published literature relevant to PD and penile reconstructive surgery. A summary of the published guidelines from major organisations is included in this review paper. Read More

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March 2018
3 Reads

A Worldwide Survey on Peyronie's Disease Surgical Practice Patterns Among Surgeons.

J Sex Med 2018 Apr 14;15(4):568-575. Epub 2018 Mar 14.

Division of Urology, St Joseph's Health Care, London, ON, Canada.

Background: Despite published guidelines on Peyronie's disease (PD), there are limited data on actual surgical practice among surgeons.

Aim: To evaluate the surgical practice patterns in PD among surgeons from different continents and members of various sexual medicine societies.

Methods: An anonymous survey on various pre-, intra-, and postoperative aspects of PD surgical care was distributed in printed format during International Society of Sexual Medicine meetings and as an online survey to International Society of Sexual Medicine members. Read More

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April 2018
8 Reads

A Novel Noninvasive Ultrasound Vibro-elastography Technique for Assessing Patients With Erectile Dysfunction and Peyronie Disease.

Urology 2018 Jun 13;116:99-105. Epub 2018 Mar 13.

Department of Urology, Mayo Clinic, Rochester, MN.

Objective: To translate a novel ultrasound vibro-elastography (UVE) technique for noninvasively measuring viscoelasticity of the penis.

Methods: A pilot study of UVE was performed in men with erectile dysfunction or Peyronie disease. Assessments were performed in triplicate on the lateral aspect of the penis (bilaterally) at 100, 150, and 200 Hz before and after erectogenic injection administration. Read More

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June 2018
6 Reads

The PICS Technique: A Novel Approach for Residual Curvature Correction During Penile Prosthesis Implantation in Patients With Severe Peyronie's Disease Using the Collagen Fleece TachoSil.

J Sex Med 2018 Mar 8;15(3):416-421. Epub 2018 Jan 8.

Department of Urology and Pediatric Urology, Julius Maximilians University of Würzburg, Würzburg, Germany. Electronic address:

Background: Correction of residual curvature during inflatable penile prosthesis (IPP) implantation in patients with Peyronie's disease (PD) by plaque incision and grafting is a common approach.

Aim: To present a novel technique for residual curvature correction during IPP implantation using collagen fleece (TachoSil, Baxter Healthcare Corp, Deerfield, IL, USA).

Methods: After the IPP (Titan Touch, Coloplast, Minneapolis, MN, USA) is placed, the implant is inflated maximally. Read More

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March 2018
15 Reads

The Multiple-Slit Technique (MUST) for Penile Length and Girth Restoration.

J Sex Med 2018 Feb 21;15(2):261-269. Epub 2017 Dec 21.

Private Practice, Vienna, Austria. Electronic address:

Background: Patients with severe erectile dysfunction (ED) and penile size issues, especially seen in Peyronie's disease (PD), are candidates for more invasive penile prosthesis insertion techniques that aim for penile length and girth reconstruction.

Aim: To present the feasibility and safety of penile length and girth restoration based on the so-called multiple-slit technique (MUST) for patients with severe ED and significant penile shortening with or without PD.

Methods: From July 2013 through January 2016, 138 patients underwent the MUST. Read More

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February 2018
33 Reads

Grafts for Peyronie's disease: a comprehensive review.

Andrology 2018 Jan 20;6(1):117-126. Epub 2017 Dec 20.

Department of Urology, 12 de Octubre University Hospital, Madrid, Spain.

The difficulty implicit in combining all the characteristics that an ideal patch to treat Peyronie's disease with a lengthening procedure should have, together with the challenges of comparing results from different series, means that the ideal patch has yet to be determined. Our objective with this review was to determine whether any given patch type is preferable to the others based on the evaluation of the results of published studies. A systematic search of the literature was conducted from PubMed until December 2016. Read More

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January 2018
2 Reads

Inhibition of penile tunica albuginea myofibroblasts activity by adipose-derived stem cells.

Exp Ther Med 2017 Nov 21;14(5):5149-5156. Epub 2017 Sep 21.

Department of Andrology, Drum Tower Hospital, Affiliated to School of Medicine, Nanjing University, Nanjing, Jiangsu 210008, P.R. China.

The activation of tunica albuginea myofibroblasts (MFs) serves an essential role in Peyronie's disease (PD). Increasing evidence has reported that adipose tissue-derived stem cells (ADSCs) have been demonstrated to attenuate the symptoms of PD in animal models. However, the mechanisms of the antifibrotic effects of ADSCs in PD remain to be fully elucidated. Read More

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November 2017
3 Reads

Surgical correction of Peyronie's disease via tunica albuginea plication: long-term follow-up.

Andrology 2018 Jan 1;6(1):47-52. Epub 2017 Dec 1.

Department of Urology, Humanitas Mater Domini, Castellanza, Italy.

Peyronie's disease (PD) is an acquired connective tissue disorder of the tunica albuginea with fibrosis and inflammation that lead to palpable plaques formation, penile curvature, and pain during erection. Patients report negative effects on main domains such as physical appearance and self-image, sexual function, and performance. The aim of this study was to evaluate plication of the albuginea outcomes after a long-term follow-up period. Read More

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January 2018
5 Reads

The digital environment in men's sexual disorders: A systematic review.

Actas Urol Esp 2017 Nov 1. Epub 2017 Nov 1.

Departmento de Urología, Hospital Clínic de Barcelona, Barcelona, España.

Context: The revolution of digital technologies constitutes a new setting for the patient-physician relationship and provides patients with a scenario of privacy and universal access to a vast amount of information. However, there is little information on how digital resources are used and what their advantages and disadvantages are.

Objectives: To explore the scope of the scientific research on the use of digital technology related to men's sexual disorders and to analyze the primary sources of digital information related to this field. Read More

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November 2017
5 Reads

Successful Treatment of Residual Curvature in Peyronie Disease in Men Previously Treated With Intralesional Collagenase Clostridium Histolyticum.

Urology 2017 Dec 5;110:110-113. Epub 2017 Sep 5.

Department of Urology, Tulane University School of Medicine, New Orleans, LA. Electronic address:

Objective: To determine the success and feasibility of surgically correcting residual curvature after intralesional collagenase clostridium histolyticum (CCH) for the treatment of Peyronie disease (PD).

Methods: We performed a retrospective analysis of patients who had intralesional CCH treatment for PD and who subsequently underwent penile plication (PP), plaque incision and grafting (PIG), or inflatable penile prosthesis (IPP) placement.

Results: Ten men who underwent PP, PIG, or IPP for the treatment of residual curvature after intralesional CCH were identified. Read More

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December 2017
36 Reads

Collagenase Clostridium histolyticum in the Treatment of Peyronie's Disease-A Review of the Literature and a New Modified Protocol.

Sex Med Rev 2017 10 2;5(4):529-535. Epub 2017 Sep 2.

Andrology Department, The Institute of Urology and University College London Hospital, London, UK.

Introduction: Peyronie's disease (PD) is a common condition that results in penile deformity, which makes sexual intercourse difficult or impossible, and causes psychological, emotional, and relationship difficulties for the man affected and his partner. Collagenase Clostridium histolyticum (CCH; Xiapex, Xiaflex) is the first licensed non-surgical treatment option for PD. The safety and efficacy have been demonstrated in two large phase III randomized controlled trials (IMPRESS I and IMPRESS II). Read More

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October 2017
23 Reads

Dupuytren-Like Contracture of the Foot: Ledderhose Disease.

Surg J (N Y) 2016 Jul 21;2(3):e102-e104. Epub 2016 Sep 21.

Department of Plastic, Reconstructive, and Aesthetic Surgery, Selcuk University Medical Faculty, Konya, Turkey.

 Plantar fibromatosis is a rare hyperproliferative disease of plantar aponeurosis and is also called Ledderhose disease. Case properties and treatment are discussed in this report.  A 30-year-old man presented with painful bilateral plantar nodules. Read More

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July 2016
30 Reads

Penile Doppler ultrasonography revisited.

Ultrasonography 2018 Jan 10;37(1):16-24. Epub 2017 Jun 10.

Department of Urology and Urological Science Institute, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.

Penile Doppler ultrasonography is a high-performing, noninvasive or minimally-invasive imaging modality that allows the depiction of the normal anatomy and macroscopic pathologic changes in real time. Moreover, functional changes in penile blood flow, as seen in erectile dysfunction (ED), can be analyzed using color Doppler ultrasonography (CDUS). This review article describes the normal sonographic anatomy of the penis, the sonographic technique for evaluating ED, the normal phases of erection, and the various causes of ED. Read More

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January 2018
13 Reads

Extracellular matrix alterations in the Peyronie's disease.

J Adv Res 2017 Jul 15;8(4):455-461. Epub 2017 Jun 15.

Biochemistry Departament, Faculdade de Medicina do ABC, Santo André 09060-650, Brazil.

Peyronie's disease is characterized by fibrous plaque formation of the tunica albuginea, causing penile deformity and fertility problems. The aim of the present study was to investigate alterations in the extracellular matrix in Peyronie's disease. The study used tissues collected by surgical procedure from individuals that presented a well-established disease, while control samples were obtained by biopsies of fresh cadavers. Read More

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July 2017
13 Reads

Evaluation of intralesional injection of hyaluronic acid compared with verapamil in Peyronie's disease: preliminary results from a prospective, double-blinded, randomized study.

Andrology 2017 07;5(4):771-775

Urology Section, Department of Surgery, University of Catania, Catania, Italy.

Several intralesional therapeutic protocols have been proposed for the treatment of Peyronie's disease. Among all, hyaluronic acid (HA) and verapamil have been differently tested. We aimed to evaluate the efficacy of intralesional verapamil (ILVI) compared with intralesional HA in patients with early onset of Peyronie's disease (PD). Read More

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July 2017
14 Reads

Penile Plication With or Without Degloving of the Penis Results in Similar Outcomes.

Sex Med 2017 Sep 13;5(3):e142-e147. Epub 2017 Jul 13.

Department of Urology, Uludag University, School of Medicine, Bursa, Turkey.

Background: Penile plication techniques with or without degloving offer a minimally invasive option for the treatment of penile curvature.

Aim: To review the outcomes of penile plication surgery and patient satisfaction with and without degloving of the penis.

Methods: We conducted a retrospective analysis of 52 patients who underwent penile plication for the treatment of Peyronie disease or congenital penile curvature. Read More

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September 2017
9 Reads

Prevalence of Peyronie's Disease-Like Symptoms in Men Presenting With Dupuytren Contractures.

Sex Med 2017 Sep 1;5(3):e135-e141. Epub 2017 Jul 1.

Department of Orthopaedic Surgery, University of California-Davis, Sacramento, CA, USA.

Introduction: Peyronie's disease (PD) and Dupuytren contractures (DC) are often comorbid and are believed to have a similar underlying pathophysiologic mechanism.

Aim: To investigate the prevalence of PD-like symptoms (PDLS) in men with DC.

Methods: From October 2013 to December 2016, men who were seen and evaluated for DC were offered the opportunity to participate in an anonymous survey. Read More

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September 2017
18 Reads

Safety and effectiveness of collagenase clostridium histolyticum in the treatment of Peyronie's disease using a new modified shortened protocol.

BJU Int 2017 11 14;120(5):717-723. Epub 2017 Jul 14.

Andrology Department, University College London Hospital and The Institute of Urology London and St Peter's Andrology Centre, London, UK.

Objectives: To evaluate the efficacy and safety of collagenase clostridium histolyticum (CCH; Xiapex , Xiaflex ) in the treatment of Peyronie's disease (PD) using a new modified treatment protocol that aims at reducing the number of injections needed and reducing patient visits, thus reducing the duration and cost of treatment.

Patients And Methods: A prospective study of 53 patients with PD who had treatment with CCH at a single centre using a new modified protocol. The angle of curvature assessment after an intracavernosal injection of prostaglandin E1, the International Index of Erectile Function (IIEF) and Peyronie's Disease Questionnaire (PDQ) were completed at baseline and at week 12 (4 weeks after the last injection). Read More

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November 2017
16 Reads

Factors Associated With Erectile Dysfunction and the Peyronie's Disease Questionnaire in Patients With Peyronie Disease.

Urology 2017 Sep 26;107:155-160. Epub 2017 May 26.

Tulane University Health Sciences Center, New Orleans, LA.

Objective: To elucidate patient characteristics that impact symptom-related bother and erectile function in patients with Peyronie disease (PD).

Methods: A post hoc analysis used data from patients with PD (ie, had PD symptoms ≥12 months and penile curvature deformity of 30-90 degrees) who received ≥1 injection of study medication in 2 phase 3 trials of collagenase clostridium histolyticum (Investigation for Maximal Peyronie's Reduction Efficacy and Safety Study I [n = 417] and Investigation for Maximal Peyronie's Reduction Efficacy and Safety Study II [n = 415]). The Covariance Analysis of Linear Structural Equations procedure was used to estimate the potential relationship of specified variables on the level of distress and erectile dysfunction associated with PD as measured by the Peyronie's Disease Questionnaire and the International Index of Erectile Function, erectile function domain. Read More

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September 2017
16 Reads

Penile ossification: A reconstructive challenge.

Rev Urol 2017 ;19(1):64-67

Department of Urology, University of Texas Southwestern Medical CenterDallas, TX.

Penile ossification is a rare condition that occurs most commonly in acquired cases of penile deformity. We report the case of a 43-year-old man with Peyronie disease who was incidentally found to have significant ossified tissue in his penile corpora during complex placement of an inflatable penile prosthesis (IPP). His clinical course was later complicated by impending distal extrusion of his IPP laterally, necessitating corporoplasty. Read More

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January 2017
13 Reads