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    1 OF 38

    Penile metastasis from rectal adenocarcinoma: a case report.
    BMC Res Notes 2017 Nov 6;10(1):564. Epub 2017 Nov 6.
    Department of Pathology, Hassan II University Hospital, Fès, Morocco.
    Background: Despite its rich vasculature, the penis is rarely involved by metastasis. Since the first description of penile metastasis in 1870, fewer than 500 cases have been reported in the literature. The pelvic organs are the main source of primary tumors that metastasize to the penis. Read More

    Complications of penile self-injections: investigation of 680 patients with complications following penile self-injections with mineral oil.
    World J Urol 2017 Oct 28. Epub 2017 Oct 28.
    Urological Research Center (URC), Department of Urology, Lillebaelt Hospital, Fredericia, Denmark.
    Objective: Penile implants and injection of foreign materials have been described in texts like Kama Sutra for more than 1500 years, and are still being practiced around the world. The extent of this practice is unknown, and the documentation available today only scratches the surface. This study investigates and documents the complications after penile self-injections at the Mae Tao Clinic. Read More

    [Buccal mucosa transplant the concept of ideal graft in surgical management of peyronies disease].
    Urologiia 2017 Sep(4):68-72
    N.I. Pirogov RNRMU of Minzdrav of Russia, Moscow, Russia.
    Introduction: Surgical techniques in managing Peyronies disease include plication corporoplasty, plaque incision, grafting and penile prosthesis implantation. The question of an ideal transplant for corporoplasty remains open.

    Aim: To evaluate the effectiveness of the substitution corporoplasty using buccal mucosa transplant (BMT) in treating Peyronies disease. Read More

    Successful Treatment of Residual Curvature in Peyronie Disease in Men Previously Treated With Intralesional Collagenase Clostridium Histolyticum.
    Urology 2017 Sep 5. Epub 2017 Sep 5.
    Department of Urology, Tulane University School of Medicine, New Orleans, LA. Electronic address:
    Objective: To determine the success and feasibility of surgically correcting residual curvature after intralesional collagenase clostridium histolyticum (CCH) for the treatment of Peyronie disease (PD).

    Methods: We performed a retrospective analysis of patients who had intralesional CCH treatment for PD and who subsequently underwent penile plication (PP), plaque incision and grafting (PIG), or inflatable penile prosthesis (IPP) placement.

    Results: Ten men who underwent PP, PIG, or IPP for the treatment of residual curvature after intralesional CCH were identified. Read More

    Collagenase Clostridium Histolyticum in the Treatment of Peyronie's Disease: Review of a Minimally Invasive Treatment Option.
    World J Mens Health 2017 09 6. Epub 2017 Sep 6.
    Department of Urology, Tulane University School of Medicine, New Orleans, LA, USA.
    Peyronie's disease (PD) is an inflammatory disorder characterized by an abnormal collagen deposition in the tunica albuginea of the penis, leading to fibrous and non-compliant plaques that can impede normal erection. Although pharmacological treatments are available, only intralesional injection therapy and surgical reconstruction have demonstrated tangible clinical efficacy in the management of this condition. Intralesional injection of collagenase clostridium histolyticum (CCH) has come to the forefront of minimally invasive treatment of PD. Read More

    Collagenase Clostridium histolyticum in the Treatment of Peyronie's Disease-A Review of the Literature and a New Modified Protocol.
    Sex Med Rev 2017 Oct 2;5(4):529-535. Epub 2017 Sep 2.
    Andrology Department, The Institute of Urology and University College London Hospital, London, UK.
    Introduction: Peyronie's disease (PD) is a common condition that results in penile deformity, which makes sexual intercourse difficult or impossible, and causes psychological, emotional, and relationship difficulties for the man affected and his partner. Collagenase Clostridium histolyticum (CCH; Xiapex, Xiaflex) is the first licensed non-surgical treatment option for PD. The safety and efficacy have been demonstrated in two large phase III randomized controlled trials (IMPRESS I and IMPRESS II). Read More

    Dupuytren-Like Contracture of the Foot: Ledderhose Disease.
    Surg J (N Y) 2016 Jul 21;2(3):e102-e104. Epub 2016 Sep 21.
    Department of Plastic, Reconstructive, and Aesthetic Surgery, Selcuk University Medical Faculty, Konya, Turkey.
    Introduction  Plantar fibromatosis is a rare hyperproliferative disease of plantar aponeurosis and is also called Ledderhose disease. Case properties and treatment are discussed in this report. Case Report  A 30-year-old man presented with painful bilateral plantar nodules. Read More

    Penile Doppler ultrasonography revisited.
    Ultrasonography 2017 Jun 10. Epub 2017 Jun 10.
    Department of Urology and Urological Science Institute, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
    Penile Doppler ultrasonography is a high-performing, noninvasive or minimally-invasive imaging modality that allows the depiction of the normal anatomy and macroscopic pathologic changes in real time. Moreover, functional changes in penile blood flow, as seen in erectile dysfunction (ED), can be analyzed using color Doppler ultrasonography (CDUS). This review article describes the normal sonographic anatomy of the penis, the sonographic technique for evaluating ED, the normal phases of erection, and the various causes of ED. Read More

    An unanswered question in pediatric urology: the post pubertal persistence of prepubertal congenital penile curvature correction by tunical plication.
    Int Braz J Urol 2017 Sep-Oct;43(5):925-931
    Department of Urology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
    Objective: The aim of this study is to analyze post pubertal results of pre pubertal tunica albuginea plication with non-absorbable sutures in the correction of CPC.

    Materials And Methods: The files of patients who underwent tunica albuginea plication without incision (dorsal/lateral) were retrospectively reviewed. Patients younger than 13 years of age at the time of operation and older than 14 years of age in November 2015 were included. Read More

    Extracellular matrix alterations in the Peyronie's disease.
    J Adv Res 2017 Jul 15;8(4):455-461. Epub 2017 Jun 15.
    Biochemistry Departament, Faculdade de Medicina do ABC, Santo André 09060-650, Brazil.
    Peyronie's disease is characterized by fibrous plaque formation of the tunica albuginea, causing penile deformity and fertility problems. The aim of the present study was to investigate alterations in the extracellular matrix in Peyronie's disease. The study used tissues collected by surgical procedure from individuals that presented a well-established disease, while control samples were obtained by biopsies of fresh cadavers. Read More

    Evaluation of intralesional injection of hyaluronic acid compared with verapamil in Peyronie's disease: preliminary results from a prospective, double-blinded, randomized study.
    Andrology 2017 Jul;5(4):771-775
    Urology Section, Department of Surgery, University of Catania, Catania, Italy.
    Several intralesional therapeutic protocols have been proposed for the treatment of Peyronie's disease. Among all, hyaluronic acid (HA) and verapamil have been differently tested. We aimed to evaluate the efficacy of intralesional verapamil (ILVI) compared with intralesional HA in patients with early onset of Peyronie's disease (PD). Read More

    Penile Plication With or Without Degloving of the Penis Results in Similar Outcomes.
    Sex Med 2017 Sep 13;5(3):e142-e147. Epub 2017 Jul 13.
    Department of Urology, Uludag University, School of Medicine, Bursa, Turkey.
    Background: Penile plication techniques with or without degloving offer a minimally invasive option for the treatment of penile curvature.

    Aim: To review the outcomes of penile plication surgery and patient satisfaction with and without degloving of the penis.

    Methods: We conducted a retrospective analysis of 52 patients who underwent penile plication for the treatment of Peyronie disease or congenital penile curvature. Read More

    Prevalence of Peyronie's Disease-Like Symptoms in Men Presenting With Dupuytren Contractures.
    Sex Med 2017 Sep 1;5(3):e135-e141. Epub 2017 Jul 1.
    Department of Orthopaedic Surgery, University of California-Davis, Sacramento, CA, USA.
    Introduction: Peyronie's disease (PD) and Dupuytren contractures (DC) are often comorbid and are believed to have a similar underlying pathophysiologic mechanism.

    Aim: To investigate the prevalence of PD-like symptoms (PDLS) in men with DC.

    Methods: From October 2013 to December 2016, men who were seen and evaluated for DC were offered the opportunity to participate in an anonymous survey. Read More

    Safety and effectiveness of collagenase clostridium histolyticum in the treatment of Peyronie's disease using a new modified shortened protocol.
    BJU Int 2017 Nov 14;120(5):717-723. Epub 2017 Jul 14.
    Andrology Department, University College London Hospital and The Institute of Urology London and St Peter's Andrology Centre, London, UK.
    Objectives: To evaluate the efficacy and safety of collagenase clostridium histolyticum (CCH; Xiapex(®) , Xiaflex(®) ) in the treatment of Peyronie's disease (PD) using a new modified treatment protocol that aims at reducing the number of injections needed and reducing patient visits, thus reducing the duration and cost of treatment.

    Patients And Methods: A prospective study of 53 patients with PD who had treatment with CCH at a single centre using a new modified protocol. The angle of curvature assessment after an intracavernosal injection of prostaglandin E1, the International Index of Erectile Function (IIEF) and Peyronie's Disease Questionnaire (PDQ) were completed at baseline and at week 12 (4 weeks after the last injection). Read More

    Factors Associated With Erectile Dysfunction and the Peyronie's Disease Questionnaire in Patients With Peyronie Disease.
    Urology 2017 Sep 26;107:155-160. Epub 2017 May 26.
    Tulane University Health Sciences Center, New Orleans, LA.
    Objective: To elucidate patient characteristics that impact symptom-related bother and erectile function in patients with Peyronie disease (PD).

    Methods: A post hoc analysis used data from patients with PD (ie, had PD symptoms ≥12 months and penile curvature deformity of 30-90 degrees) who received ≥1 injection of study medication in 2 phase 3 trials of collagenase clostridium histolyticum (Investigation for Maximal Peyronie's Reduction Efficacy and Safety Study I [n = 417] and Investigation for Maximal Peyronie's Reduction Efficacy and Safety Study II [n = 415]). The Covariance Analysis of Linear Structural Equations procedure was used to estimate the potential relationship of specified variables on the level of distress and erectile dysfunction associated with PD as measured by the Peyronie's Disease Questionnaire and the International Index of Erectile Function, erectile function domain. Read More

    A new technique, combined plication-incision (CPI), for correction of penile curvature.
    Int Braz J Urol 2017 May 23;43. Epub 2017 May 23.
    Department of Andrology, Faculty of Medicine, Cairo University, Cairo, Egypt.
    Introduction: Penile curvature (PC) can be surgically corrected by either corporoplasty or plication techniques. These techniques can be complicated by post-operative: penile shortening, recurrent PC, painful/palpable suture knots and erectile dysfunction.

    Objective: To avoid the complications of corporoplasty and plication techniques using a new technique: combined plication-incision (CPI). Read More

    Penile ossification: A reconstructive challenge.
    Rev Urol 2017 ;19(1):64-67
    Department of Urology, University of Texas Southwestern Medical CenterDallas, TX.
    Penile ossification is a rare condition that occurs most commonly in acquired cases of penile deformity. We report the case of a 43-year-old man with Peyronie disease who was incidentally found to have significant ossified tissue in his penile corpora during complex placement of an inflatable penile prosthesis (IPP). His clinical course was later complicated by impending distal extrusion of his IPP laterally, necessitating corporoplasty. Read More

    [Penile Tuberculosis : A Case Report].
    Hinyokika Kiyo 2017 Apr;63(4):163-167
    The Department of Infection Control Team, Osaka Police Hospital.
    A 66-year-old man presented with a chief complaint of glans penis pain, induration, and discharge of pus. He was prescribed a course of antibiotics, but the condition persisted despite treatment. Thus, we differrentially diagnosed the patient with penile tuberculosis and pyoderma gangrenosum, and performed a biopsy of the penis. Read More

    Safety Profile of Collagenase Clostridium Histolyticum Stratified by Degree of Penile Curvature in Patients With Peyronie Disease.
    Urology 2017 Aug 10;106:237.e9-237.e14. Epub 2017 May 10.
    Endo Pharmaceuticals Inc., Malvern, PA.
    Objective: To examine the safety of collagenase clostridium histolyticum (CCH) in adult men with penile curvature deformity <30°. CCH is indicated for treatment of Peyronie disease in adult men with palpable plaque and a penile curvature deformity ≥30° at start of therapy; however, during treatment, patients may receive CCH injections when penile curvature deformity is <30°.

    Materials And Methods: Patients who received ≥2 CCH treatment cycles in 2 phase 3 studies (Investigation for Maximal Peyronie's Reduction Efficacy and Safety Studies I and II) were included. Read More

    Self-reported Clinical Meaningfulness Early in the Treatment Course Predicts Objective Outcomes in Men Undergoing Collagenase Clostridium histolyticum Injections for Peyronie Disease.
    Urology 2017 Aug 5;106:107-112. Epub 2017 May 5.
    Department of Urology, Mayo Clinic, Rochester, MN. Electronic address:
    Objective: To compare perceived meaningfulness early in the course of collagenase Clostridium histolyticum (CCH) with final outcomes to evaluate its use as a predictor of efficacy.

    Materials And Methods: A registry of patients undergoing CCH from March 2014 to September 2016 was maintained. Patients were recommended to complete 4 injection cycles. Read More

    Three-Dimensional Photography for Quantitative Assessment of Penile Volume-Loss Deformities in Peyronie's Disease.
    J Sex Med 2017 Jun 28;14(6):829-833. Epub 2017 Apr 28.
    Department of Urology, Columbia University College of Physicians and Surgeons, New York, NY, USA.
    Background: Non-curvature penile deformities are prevalent and bothersome manifestations of Peyronie's disease (PD), but the quantitative metrics that are currently used to describe these deformities are inadequate and non-standardized, presenting a barrier to clinical research and patient care.

    Aim: To introduce erect penile volume (EPV) and percentage of erect penile volume loss (percent EPVL) as novel metrics that provide detailed quantitative information about non-curvature penile deformities and to study the feasibility and reliability of three-dimensional (3D) photography for measurement of quantitative penile parameters.

    Methods: We constructed seven penis models simulating deformities found in PD. Read More

    Collagenase Clostridium Histolyticum in the Treatment of Urologic Disease: Current and Future Impact.
    Sex Med Rev 2017 Apr 25. Epub 2017 Apr 25.
    Department of Urology, Tulane University School of Medicine, New Orleans, LA, USA. Electronic address:
    Introduction: Peyronie's disease (PD) is a connective tissue disorder resulting in the abnormal accumulation of type I to III collagen, fibrin, and disorganized elastic fibers in the tunica albuginea of the penis. Many medical and non-pharmacologic modalities have been used in the treatment of PD; however, these approaches have proved largely ineffective, with surgery being the only definitive treatment. Intralesional injection of collagenase Clostridium histolyticum (CCH) has recently become the gold standard for minimally invasive treatment of PD, and studies have suggested the role of CCH could expand to the treatment of other urologic conditions such as urethral stricture disease. Read More

    Changes in the Effects of Peyronie's Disease After Treatment With Collagenase Clostridium histolyticum: Male Patients and Their Female Partners.
    Sex Med 2017 Jun 5;5(2):e124-e130. Epub 2017 Apr 5.
    Australian Centre for Sexual Health, St Leonards, NSW, Australia.
    Introduction: Collagenase Clostridium histolyticum (CCH) intralesional injection was efficacious for the management of Peyronie's disease (PD) in the double-blinded, randomized, placebo-controlled Investigation for Maximal Peyronie's Reduction Efficacy and Safety Studies I and II (IMPRESS I and II). Little is known about the consequences of PD or treatment on the sexual partners of affected men.

    Aim: To assess the safety and efficacy of CCH treatment in men who received placebo in the IMPRESS I or II study and to evaluate the men's PD symptoms and partner bother as reported by female sexual partners. Read More

    Role of interleukin-6 and pentraxin 3 as an early marker in Peyronie's disease.
    Kaohsiung J Med Sci 2017 Apr 28;33(4):195-200. Epub 2017 Feb 28.
    Department of Urology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, Istanbul, Turkey.
    Inflammation is mechanistically involved in the development of Peyronie's disease (PD). The aim of this study is to assess the relevance of serum pentraxin 3 (PTX3) and interleukin-6 (IL-6) concentrations in PD. The study enrolled 40 patients with PD in the acute phase and 40 healthy controls. Read More

    Clinical Experience With Penile Traction Therapy Among Men Undergoing Collagenase Clostridium histolyticum for Peyronie Disease.
    Urology 2017 Jun 24;104:102-109. Epub 2017 Mar 24.
    Department of Urology, Mayo Clinic, Rochester, MN. Electronic address:
    Objective: To evaluate the outcomes in men undergoing collagenase Clostridium histolyticum (CCH) with concurrent penile traction therapy (PTT) for the treatment of Peyronie disease (PD).

    Materials And Methods: We identified patients treated with CCH between March 2014 and July 2016. Patients were recommended to perform modeling and PTT between injection series. Read More

    Stem cell therapy for the treatment of Peyronie's disease.
    Expert Opin Biol Ther 2017 Apr 28;17(4):407-413. Epub 2017 Feb 28.
    a University Department of Urology , Sismanoglio General Hospital , Athens , Greece.
    Introduction: Like other fibrotic diseases, the cause of Peyronie's disease (PD) is still obscure. Since there is now increasing evidence for the role of Mesenchymal Stem Cells (MSCs) as potential treatment to fibrosis, it is crucial to determine their possible efficacy in the treatment of PD. Areas covered: In this review, the authors summarize the emerging data and published studies regarding the use of SCs for the treatment of PD. Read More

    Low-Intensity Extracorporeal Shockwave Therapy in Sexual Medicine: A Questionnaire-Based Assessment of Knowledge, Clinical Practice Patterns, and Attitudes in Sexual Medicine Practitioners.
    Sex Med 2017 Jun 6;5(2):e94-e98. Epub 2017 Mar 6.
    Department of Urology, Amstelland Hospital, Amstelveen, The Netherlands.
    Introduction: Low-intensity extracorporeal shockwave therapy (LI-ESWT) has emerged as a treatment option for male sexual dysfunction. However, results have been contradictory.

    Aim: To investigate the knowledge, practice patterns, and attitudes regarding LI-ESWT among experts in sexual medicine. Read More

    Sexual Rehabilitation After Treatment For Prostate Cancer-Part 2: Recommendations From the Fourth International Consultation for Sexual Medicine (ICSM 2015).
    J Sex Med 2017 Mar;14(3):297-315
    Scott Department of Urology, Baylor College of Medicine, Houston, TX, USA.
    Introduction: Sexual dysfunction is common in patients after radical prostatectomy (RP) for prostate cancer.

    Aim: To provide the International Consultation for Sexual Medicine (ICSM) 2015 recommendations concerning management strategies for post-RP erectile function impairment and to analyze post-RP sexual dysfunction other than erectile dysfunction.

    Methods: A literature search was performed using Google and PubMed database for English-language original and review articles published up to August 2016. Read More

    Contemporary Review of Grafting Techniques for the Surgical Treatment of Peyronie's Disease.
    Sex Med Rev 2017 Oct 1;5(4):544-552. Epub 2017 Mar 1.
    Department of Urology, University of California-Irvine, Irvine, CA, USA.
    Introduction: Peyronie's disease (PD) is a benign fibrotic disorder of the tunica albuginea of the penis, which can cause penile pain, curvature, shortening, erectile dysfunction, and psychological distress. Surgery is indicated when penile curvature prevents satisfactory sexual intercourse. Plaque incision or excision with grafting has been suggested as an option in patients with a penile curvature greater than 60°, a shortened penis, and/or an hourglass or complex deformity. Read More

    Survey of patient and partner satisfaction following collagenase Clostridium histolyticum treatment for Peyronie's disease.
    Andrology 2017 Mar 10;5(2):274-277. Epub 2017 Feb 10.
    Department of Urology, Tulane University School of Medicine, New Orleans, LA, USA.
    Intralesional injection of collagenase Clostridium histolyticum (CCH) is a minimally invasive, Food and Drug Administration-approved, effective treatment for Peyronie's disease (PD). To assess the satisfaction of patients and their female sexual partners (FSP) following CCH therapy for PD, we conducted a retrospective review of the records of all patients treated with CCH for PD between 04/2014 and 03/2016. Collected variables included demographics, pre- and post-treatment sexual function, penile curvature, penile vascular findings, and treatment outcomes. Read More

    Role of extracorporeal shock wave therapy in management of Peyronie's disease: A preliminary report.
    Urol Ann 2016 Oct-Dec;8(4):409-417
    Department of Urology and Genito-Urinary Surgery, Ruby Hall Clinic, Pune, Maharashtra, India.
    Introduction: Peyronie's Disease (PD) is a disease causing psycho social trauma to the patient. Multiple treatment options are available with variable results. Extra Corporeal Shock Wave Therapy (ESWT) is a new insight into the non invasive modality of management. Read More

    Stem Cells in Male Sexual Dysfunction: Are We Getting Somewhere?
    Sex Med Rev 2017 Apr 29;5(2):222-235. Epub 2016 Dec 29.
    Laboratory of Experimental Urology, Department of Development and Regeneration, KU Leuven, Leuven, Belgium. Electronic address:
    Introduction: Stem cells for sexual disorders are steadily being introduced into clinical trials. Two conditions of importance are the main target for this line of treatment, especially when regarding the wide array of translational and basic science highlighting the potential advantages of regenerative therapy: erectile dysfunction (ED) and more recently Peyronie disease (PD). Cellular therapy offers a treatment modality that might reverse disease progression. Read More

    The periprostatic venous plexus: an unusual source of fatal pulmonary embolism during corporoplasty.
    Int J Legal Med 2017 May 22;131(3):713-717. Epub 2016 Dec 22.
    Institute of Public Health, Section of Legal Medicine, Catholic University Medical School, Rome, Italy.
    When a sudden death occurs during a minor surgical intervention, it may require a careful and extensive postmortem investigation. One such case concerns a 61-year-old male patient affected by Peyronie's disease, who died suddenly during a corporoplasty procedure. Autopsy and histologic examinations showed a massive bilateral pulmonary micro-embolism brought on by periprostatic venous plexus thrombosis. Read More

    Nonsurgical treatment options in Peyronie's Disease: 2016 update.
    Turk J Urol 2016 Dec;42(4):217-223
    Department of Urology, Hamad General Hospital, Doha, Qatar.
    Peyronie's disease (PD) is an inflammatory condition of penile tunica albuginea which commonly ends with penile curvature and difficulty in vaginal penetration. Unfortunately, the pathophysiology of PD has not been completely understood. In this paper, we will review what is known about the pathophysiology of PD and the nonsurgical medical treatment options that have been trialed as a result. Read More

    Association Between Infertility and Sexual Dysfunction in Men and Women.
    Sex Med Rev 2016 Oct 4;4(4):353-365. Epub 2016 Jun 4.
    Department of Urology, University of Miami-Miller School of Medicine, Miami, FL, USA. Electronic address:
    Introduction: The relation between infertility and sexual dysfunction can be reciprocal. Causes of sexual dysfunction that affect fertility include erectile dysfunction, Peyronie's disease (abnormal penile curvature), low libido, ejaculatory disorders in men, and genito-pelvic pain/penetration disorder (GPPPD) and low sexual desire in women.

    Aim: To review the association between infertility and sexual dysfunction and discuss current management strategies to address sexual disorders in couples with infertility. Read More

    The Genetic Basis of Peyronie Disease: A Review.
    Sex Med Rev 2016 Jan 8;4(1):85-94. Epub 2016 Jan 8.
    Center for Reproductive Medicine, Baylor College of Medicine, Houston, TX, USA; Scott Department of Urology, Baylor College of Medicine, Houston, TX, USA. Electronic address:
    Introduction: Peyronie disease (PD) is a progressive fibrotic disorder of the penile tunica albuginea that results in fibrotic penile plaques and can lead to penile deformity. Characterized by aberrant fibrosis resulting in part from the persistence of myofibroblasts and altered gene expression, the molecular factors underpinning PD and other related fibrotic diatheses are just being elucidated. A genetic link to PD was first identified three decades ago using pedigree analyses. Read More

    Patient-reported long-term sexual outcomes following plication surgery for penile curvature: A retrospective 58-patient study.
    Prog Urol 2017 Jan 18;27(1):10-16. Epub 2016 Nov 18.
    Département d'urologie, centre hosptalier Lyon Sud, chemin du Grand-Revoyet, 69495 Pierre-Benite cedex, France. Electronic address:
    Objective: To evaluate long-term sexual function results following plication surgery for the correction of penile curvature using patient questionnaires.

    Methods: We performed a single-center, retrospective study in a cohort of patients with Peyronie's disease or congenital penile curvature. All patients who underwent plication surgery on the convex aspect using the Nesbit, Yachia or diamond-shaped techniques were included. Read More

    Small Intestinal Submucosa Grafting for Peyronie Disease: Outcomes and Patient Satisfaction.
    Urology 2017 Feb 4;100:117-124. Epub 2016 Nov 4.
    Department of Renal, Urological and Infectious Diseases, Centro Hospitalar de São João, Porto, Portugal; Faculty of Medicine, University of Porto, Porto, Portugal.
    Objective: To evaluate surgical outcomes and complications and assess overall patient satisfaction after small intestinal submucosa (SIS) grafting for Peyronie disease.

    Methods: Twenty-eight patients were treated with tunical incision and grafting with SIS. Mean age of the patients was 58 (range: 43-71) years. Read More

    Impact of Number of Cycles of Collagenase Clostridium Histolyticum on Outcomes in Patients With Peyronie's Disease.
    Urology 2017 Feb 2;100:125-130. Epub 2016 Nov 2.
    Department of Urology, Tulane University School of Medicine, New Orleans, LA. Electronic address:
    Objective: To analyze the impact of the number of cycles of collagenase Clostridium histolyticum (CCH) intralesional injection therapy on outcomes to further characterize CCH therapy.

    Methods: We conducted a retrospective review of the records of all patients treated with CCH for Peyronie disease between April 2014 and March 2016. Collected variables included demographics, pre- and posttreatment sexual function, penile curvature, penile vascular findings, and treatment outcomes. Read More

    A wet dressing for male genital surgery: A phase II clinical trial.
    Int Braz J Urol 2016 Nov-Dec;42(6):1220-1227
    Serviço de Urologia do Hospital das Clínicas, Departamento de Cirurgia do Centro de Ciências da Saúde da Universidade Federal de Pernambuco, UFPE, Brasil.
    Purpose: This study was to confirm the safety and efficacy of BC dressing when used in surgical male wound healing at the urogenital area.

    Methods: Open, non-controlled clinical study of phase II. A total of 141 patients, among those children, adolescents and adults with hypospadias (112), epispadias (04), phymosis (13) and Peyronie's disease (12) that had a BC dressing applied over the operated area after surgery. Read More

    Collagenase Clostridium Histolyticum for the Treatment of Peyronie's Disease: A 'Real World' Clinical Perspective.
    Drugs 2016 Oct;76(16):1523-1528
    Department of Urology, Tulane University School of Medicine, New Orleans, LA, USA.
    The introduction of collagenase Clostridium histolyticum (CCH) as a treatment option for Peyronie's disease (PD), defined as the abnormal formation of collagen on the tunica albuginea of the penis, has provided patients with a promising new conservative therapy. Studies have shown that CCH improves curvature by an average of 17°, and although patient and sexual partner satisfaction is high, the improvement has arguable clinical implications. Similarly, the efficacy and cost of CCH contrasts strongly with more invasive surgical management, and is further limited by rare, but serious, complications and several contraindications. Read More

    External Mechanical Devices and Vascular Surgery for Erectile Dysfunction.
    J Sex Med 2016 Nov;13(11):1579-1617
    Department of Urology, Rush University Medical Center, Chicago, IL, USA.
    Introduction: The field of sexual medicine is continuously advancing, with novel outcomes reported on a regular basis. Given the rapid evolution, updated guidelines are essential to inform practicing clinicians on best practices.

    Aim: To summarize the current literature and provide clinical guidelines on penile traction therapy, vacuum erection devices, and penile revascularization. Read More

    The clinical spectrum of syphilitic balanitis of Follmann: report of five cases and a review of the literature.
    J Eur Acad Dermatol Venereol 2016 Oct 16;30(10):1810-1813. Epub 2016 Jul 16.
    Outpatient Clinic of Dermato-Venereology, Triemli Hospital, Zürich, Switzerland.
    Background: Eugène Follmann first described syphilitic balanitis as a manifestation of primary syphilis in 1948 and since then it has been known as syphilitic balanitis of Follmann (SBF). So far, SBF has rarely been described in literature.

    Objectives: We are reporting five additional cases of SBF considering the broad differential diagnosis of balanitis. Read More

    A prospective, randomized, single - blind study comparing intraplaque injection of thiocolchicine and verapamil in Peyronie's Disease: a pilot study.
    Int Braz J Urol 2016 Sep-Oct;42(5):1005-1009
    Departamento de Urologia, Hospital Ipiranga, São Paulo, Brasil.
    Objectives: To compare the response to tiocolchicine and verapamil injection in the plaque of patients with Peyronie's disease.

    Materials And Methods: Prospective, single-blind, randomized study, selecting patients who have presented Peyronie's disease for less than 18 months. Thiocolchicine 4mg or verapamil 5mg were given in 7 injections (once a week). Read More

    --- ---Recent advances in managing Peyronie's disease.
    F1000Res 2016 26;5. Epub 2016 Sep 26.
    St James Hospital, Leeds, LS9 7TF, UK.
    Peyronie's disease remains an under-reported and debilitating problem which can result in significant physical and psychological symptoms for some men. The classic symptom complex includes penile curvature, penile plaque, and penile pain. Men can also present with erectile dysfunction, penile instability, and penile shortening, alongside feelings of low mood/libido, dysmorphobia, and low self-esteem. Read More

    Nonsurgical Interventions for Peyronie's Disease: Update as of 2016.
    World J Mens Health 2016 Aug 23;34(2):65-72. Epub 2016 Aug 23.
    The James Buchanan Brady Urological Institute and Department of Urology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
    Peyronie's disease (PD) is a debilitating condition of the penis that leads to significant pain, erectile dysfunction, and emotional distress in men. PD is likely underreported due to lack of knowledge of the disease and the absence of well-established available treatments. Surgical treatment can lead to sustained improvements, but is often associated with penile shortening and places the patient at risk for perioperative morbidity. Read More

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