2,314 results match your criteria Peyronie Disease


Safety and Efficacy Study of Collagenase Clostridium Histolyticum Applied With an Intensive Protocol in the Treatment of Peyronie's Disease.

Sex Med 2021 Jun 3;9(3):100375. Epub 2021 Jun 3.

Department of Urology, University Hospital San Cecilio, Granada, Spain.

Introduction: Collagenase clostridium histolyticum (CCH) is a treatment for Peyronie's disease (PD) whose efficacy and safety has been demonstrated using a classic protocol and a shortened protocol.

Aim: To evaluate the efficacy and safety of an even more intense protocol in which a CCH injection is applied for 3 separate cycles of 1 week.

Methods: Prospective, nonrandomized, clinical study of a cohort of 13 patients with PD and non-ventral curvatures, between 30 and 90 degrees and with stable disease were included. Read More

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Management of Patients With Normal Physical Exams and Ultrasound Evidence of Isolated Septal and Punctate Penile Scarring.

Sex Med 2021 May 30;9(3):100346. Epub 2021 May 30.

Division of Urology, London Health Sciences Centre , London, Ontario, Canada; Division of Urology, Western University Ringgold Standard Institution, London, Ontario, Canada. Electronic address:

Introduction: Atypical penile tunical lesions including isolated septal (ISS) and punctate scarring (PS) are an under recognized and difficult to treat subset of Peyronie's disease (PD) that often present with normal physical exams. Current guidelines provide little direction in the treatment of these men.

Aim: To review the results of our treatment approach in men with ISS and PS. Read More

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Efficacy of a Novel Penile Traction Device in Improving Penile Length and Erectile Function Post Prostatectomy: Results from a Single-Center Randomized, Controlled Trial.

J Urol 2021 Jun 1:101097JU0000000000001792. Epub 2021 Jun 1.

Mayo Clinic, Rochester, Minnesota.

Purpose: RestoreX is a novel penile traction therapy device, with randomized, controlled data demonstrating improvements in penile length and erectile function after 30 to 90 minutes of daily use in men with Peyronie's disease. We sought to determine if similar improvements could be achieved post prostatectomy.

Materials And Methods: Men post prostatectomy were randomly assigned to control or one of 2 penile traction therapy protocols for 6 months, followed by a 3-month open-label phase. Read More

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Low-intensity extracorporeal shock wave therapy for Peyronie's disease: a single-center experience.

Asian J Androl 2021 May 21. Epub 2021 May 21.

APHP - Sorbonne University, Pitié Salpêtrière, Academic Urology Unit, 83 bvd Hôpital, Paris 75013, France.

The aim of this article is to assess the outcomes of a low-intensity extracorporeal shock wave therapy (LiESWT) protocol for the treatment of Peyronie's disease (PD). Patients treated for PD were prospectively recorded, and data were retrospectively reviewed. Age, characteristics of fibrous plaques, concomitant treatments, International Index of Erectile Function (IIEF-5), Lue score, and pain score on Likert scale were collected. Read More

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Continuing Collagenase Clostridium Histolyticum Injections Among Initial Nonresponders Results in Significant Curvature Improvements in the Majority of Peyronie's Disease Men.

J Sex Med 2021 May 18. Epub 2021 May 18.

Male Fertility and Peyronie's Clinic, Orem, UT, United States. Electronic address:

Background: It is currently unclear if men with Peyronie's Disease (PD) who achieve minimal benefits with the first 2 series of Collagenase Clostridium Histolyticum (CCH) injections should continue with additional injections.

Aim: To analyze curvature improvements from the final two series of CCH injections based on amount of improvement during the first 2 series.

Methods: A prospective registry was analyzed of all men undergoing CCH injections for PD at a single institution. Read More

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Effects of patients' understanding and choice of surgical types on postoperative outcomes of Peyronie's disease: a single-center retrospective study of 108 patients.

Asian J Androl 2021 May 11. Epub 2021 May 11.

Department of Urology and Andrology, Ninth People's Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200011, China.

Surgical correction can be considered for treating patients with a chronic phase of Peyronie's disease (PD) and persistent penile curvature. In clinical practice, some patients pay too much attention to surgical complications and refuse the recommended feasible surgical types. Meanwhile, they require operations according to their preferences. Read More

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Single-cell Transcriptomics Uncover a Novel Role of Myeloid Cells and T-lymphocytes in the Fibrotic Microenvironment in Peyronie's Disease.

Eur Urol Focus 2021 May 4. Epub 2021 May 4.

Laboratory of Experimental Urology, Department of Development and Regeneration, KU Leuven, Leuven, Belgium; Department of Urology, University Hospitals Leuven, Leuven, Belgium.

Background: Peyronie's disease (PD) is an acquired fibrotic disease affecting the penile tunica albuginea that can lead to curvature and deformities, shortening, and erectile dysfunction. Although immunological mechanisms have been suggested for the pathophysiology of PD, these have not been investigated using single-cell transcriptomics.

Objective: To investigate the immunological signature of plaques from PD patients using immunohistochemistry (IHC) and single-cell RNA sequencing (scRNA-Seq). Read More

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[Recommendations of the Committee of Andrology and Sexual Medicine of the AFU concerning the management of andrological and sexual medicine pathologies during the COVID-19 crisis].

Prog Urol 2021 Jun-Jul;31(8-9):495-502. Epub 2020 Aug 18.

265, avenue des États-du-Languedoc, Montpellier, 34000, France.

Objective: To assist urologists in the management of andrological and sexual medicine pathologies during the COVID-19 crisis.

Material And Method: Use of the formalized consensus method.

Results: The medical and surgical management of patients in andrology and sexual medicine must be adapted. Read More

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[French Urological Association (AFU) guidelines for Peyronie's disease assessment and treatment].

Prog Urol 2021 Jun-Jul;31(8-9):477-494. Epub 2021 Apr 30.

Centre d'urologie du Polygone, Montpellier.

Introduction: Peyronie's disease is a common cause for consultation in urology. Many controversies surround its treatment. No French Guidelines have been published so far. Read More

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Men's Health: Male Sexual Dysfunction.

Authors:
Karl T Rew

FP Essent 2021 Apr;503:28-33

University of Michigan Medical School Department of Family Medicine, 300 North Ingalls St NI4C06, Ann Arbor, Michigan 48109-5435.

Human sexual function is complex and multidimensional, with physiologic and psychological components. The common sexual dysfunctions in men have significant overlap. Low sexual desire in men includes a lack of interest in thinking about sex or in being sexual, alone or with a partner. Read More

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Fibroproliferative disorders and diabetes: Understanding the pathophysiologic relationship between Peyronie's disease, Dupuytren disease and diabetes.

Endocrinol Diabetes Metab 2021 04 31;4(2):e00195. Epub 2020 Oct 31.

Department of Dermatology and Cutaneous Biology The Joan and Joel Rosenbloom Research Center for Fibrotic Diseases Sidney Kimmel Medical College Thomas Jefferson University Philadelphia PA USA.

Introduction: Fibrosis is characterized by dysregulation and accumulation of extracellular matrix. Peyronie's disease and Dupuytren disease are fibroproliferative disorders of the tunica albuginea of the penis and fascia of the hand, respectively. Chronic hyperglycaemia due to diabetes mellitus can also lead to tissue injury and fibrosis. Read More

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NON-SURGICAL TREATMENT OF PEYRONIE'S DISEASE: A COMPREHENSIVE REVIEW.

Wiad Lek 2021 ;74(3 cz 1):539-545

CITY CLINICAL HOSPITAL № 4, DNIPRO, UKRAINE.

This review article focuses on conservative treatment options, topical, intralesional therapy, traction and vacuum therapy. A PubMed database search was performed for studies that were published between 1948 and 2019. Search keywords included "Peyronie's disease," "conservative therapy," "traction treatment," "extracorporeal shock wave therapy," "topical and oral therapies," and "vaccum therapy. Read More

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Evaluation of alternative diluents for clinical use of collagenase clostridium histolyticum (CCH-aaes).

J Cosmet Dermatol 2021 Jun 5;20(6):1643-1647. Epub 2021 May 5.

Endo Pharmaceuticals, Inc, Horsham, PA, USA.

Background: Collagenase clostridium histolyticum (CCH-aesthetic formulation [CCH-aaes]; QWO™ [Endo Aesthetics, Malvern PA, USA] is approved as a subcutaneous injection for treatment of cellulite. In the aesthetic practice, dilution of marketed products is commonly employed to tailor treatments to individual patients or off-label locations. Dilution beyond the 0. Read More

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Penile Mondor's disease: Imaging in two cases.

J Radiol Case Rep 2020 Dec 31;14(12):24-30. Epub 2020 Dec 31.

Department of Diagnostic Imaging and Laboratory Medicine, Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy.

Penile Mondor's disease is a rare and under-recognized benign genital condition consisting of an isolated thrombosis of the dorsal superficial vein of the penis. Symptoms do not show distinctive features and there are asymptomatic cases. The patients usually present with a cord-like induration at dorsum of the penis. Read More

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December 2020

Predictors of Depression in Men With Peyronie's Disease Seeking Evaluation.

J Sex Med 2021 04 10;18(4):783-788. Epub 2021 Mar 10.

Sexual & Reproductive Medicine Program, Urology Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA. Electronic address:

Background: Peyronie's disease (PD) has negative impacts on the psychosocial status of men including depression warranting clinical evaluation in up to 50% of men.

Aim: To examine predictors of depression in patients with early PD seeking evaluation.

Methods: All PD patients at a high-volume PD practice underwent screening and curvature assessment after intracavernosal injection. Read More

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Treatment Patterns and Healthcare Outcomes with Collagenase Clostridium Histolyticum vs Surgery in Peyronie's Disease: A Retrospective Claims Database Analysis.

Sex Med 2021 Apr 5;9(2):100321. Epub 2021 Mar 5.

Endo Pharmaceuticals Inc, Malvern, PA, USA.

Introduction: Treatments for Peyronie's disease (PD) include surgical management and collagenase clostridium histolyticum (CCH).

Aims: To evaluate PD treatment trends after CCH approval and compare clinical outcomes in CCH- and surgery-treated cohorts.

Methods: Patients newly diagnosed with PD between January 2011 and December 2017 were identified in a U. Read More

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Specific urogenital disease information-revealing male genital votive offerings dedicated to gods in ancient age sanctuary medicine.

Arch Esp Urol 2021 Mar;74(2):239-246

Department of Urology. Istanbul University. Istanbul School of Medicine. Fatih. Istanbul. Turkey.

Objectives:  The people of ancient age appealed to sanctuaries of different gods and goddesses they believed to have healing powers and consecrated anatomical votive offerings representing their sick or healed organs. Male genital organ votives were also present among these votives. In this article, male genital organ votive offerings presented to gods and goddesses were examined and the votives giving information about the diseases they indicated were revealed in contemporary medicine. Read More

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Treatments of Peyronie's disease with Scutellaria baicalensis and surgery according to the disease course: a single-center retrospective study of 261 patients.

Ann Palliat Med 2021 Mar 11;10(3):2979-2989. Epub 2021 Feb 11.

Department of Urology and Andrology, Ninth People's Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.

Background: Oral medication therapies are more conventional than other non-surgical therapies in the acute phase of Peyronie's disease (PD). Although the commonly used oral drugs for PD have shown poor or indeterminate outcomes, most patients prefer oral medications. The aim of this study was to evaluate the efficacy and safety of Scutellaria baicalensis extract for treating acute-phase PD patients and examine the practicality of treatment strategies for PD according to the disease course. Read More

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3D-Printed Flexible Penile Model Simulator for Plaque Incision and Graft for Peyronie's Disease.

Sex Med 2021 Apr 13;9(2):100318. Epub 2021 Feb 13.

Reconstructive Urology and Andrology Section, Department of Urology, Ipanema Federal, Rio de Janeiro, Brazil. Electronic address:

Introduction: Plaque incision and graft (PIG) is suggested for the treatment of significant Peyronie's disease (PD), but most surgeons perform very few PIG surgeries annually, and the number of PD cases requiring PIG is inadequate to maintain the necessary skills and completely master the procedure.

Aim: To develop and validate a new 3D-printed model of a curved penis and graft to simulate PIG surgery. This is the first PIG surgical training simulator described in the medical literature. Read More

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Efficacy and safety of collagenase Clostridium histolyticum in Peyronie's disease following a modified treatment protocol.

Actas Urol Esp (Engl Ed) 2021 Apr 31;45(3):215-219. Epub 2021 Jan 31.

Departamento de Urología, Hospital Clínic, Barcelona, España.

Introduction: Collagenase Clostridium histolyticum (CCH) is the only approved treatment for conservative management of Peyronie's disease (PD) that has demonstrated efficacy and safety in clinical trials. However, as the standard treatment protocol is time and resource consuming, we are introducing a new CCH treatment protocol with a more cost-effective profile. Our goal is to evaluate its efficacy and safety. Read More

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Human Penile Ossification: A Rare Cause of Sexual Dysfunction - A Case Report and Review of the Literature.

Cureus 2021 Jan 13;13(1):e12675. Epub 2021 Jan 13.

Urology, Loyola University Medical Center, Maywood, USA.

Human penile ossification is a rare urologic condition with approximately 40 cases reported in the literature so far. While bone is essential for penetrative intercourse in many non-human mammals, human penile ossification appears to be part of a metaplastic process occurring after injury or trauma. Conditions such as Peyronie's disease, diabetes mellitus, local trauma, and end-stage renal disease have been associated with this entity. Read More

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January 2021

Comparison of two different grafts for the surgical treatment of peyronie's disease.

Andrologia 2021 Apr 24;53(3):e13987. Epub 2021 Jan 24.

Department of Urology, Istanbul Göztepe Training and Research Hospital, Medeniyet University, Istanbul, Turkey.

The aim of this study was to compare two different graft techniques, namely saphenous vein (SV) and buccal mucosa (BM) used together with plaque incision for the treatment of Peyronie's disease (PD) in terms of success, safety and patient and partner satisfaction. The study included 41 patients diagnosed with PD and treated with plaque incision and grafting between December 2015 and November 2019. Eighteen patients underwent plaque incision and BM grafting while the remaining 23 patients underwent plaque incision and SV grafting. Read More

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The Management of Penile Fracture: a Review of the Literature with Special Consideration for Patients Undergoing Collagenase Clostridium Histolyticum Injection Therapy.

Curr Urol Rep 2021 Jan 20;22(2):13. Epub 2021 Jan 20.

Department of Urology, Tulane University School of Medicine, 1430 Tulane Ave, 8642, New Orleans, LA, 70112, USA.

Purpose Of Review: To review the current literature on acute management of traumatic penile fracture, with a specific discussion of those injuries following collagenase clostridium histolyticum (CCH) injections for the treatment of Peyronie's disease.

Recent Findings: The immediate repair of traumatic penile fracture injury is associated with significantly better prognosis for long-term sexual health. Corporal disruption following CCH administration has several distinct features, and the trend is to manage these patients conservatively in the absence of urethral injury. Read More

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January 2021

Comparing and Contrasting Peyronie's Disease Guidelines: Points of Consensus and Deviation.

J Sex Med 2021 02 7;18(2):363-375. Epub 2021 Jan 7.

Department of Urology, Mayo Clinic, Rochester, MN, USA. Electronic address:

Background: Peyronie's disease (PD) is a challenging clinical entity. To assist clinicians with diagnosis and management, four separate organizations have published PD guidelines over the past five years, but there remains a lack of consensus and data-driven recommendations for many aspects of diagnosis and treatment.

Aim: To compare and contrast PD guidelines, highlighting key similarities and differences among the guideline panel recommendations and identify areas for further research. Read More

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February 2021

Current Status for Semirigid Penile Prosthetic Devices.

Curr Urol Rep 2021 Jan 9;22(2). Epub 2021 Jan 9.

Tampa General Hospital, 1 Tampa General Circle, Tampa, FL, 33606, USA.

Purpose Of Review: The goal of this paper was to evaluate the current use of semirigid penile prosthesis (SRPP), surgical techniques for insertion of SRPP, and how to prevent and approach surgical complications.

Recent Findings: SRPP is a valid option for those who are refractory to medical therapy for erectile dysfunction (ED) and even more appropriate for specific subsets of patient populations. It is important for urologists to know which patient population SRPP is preferred for. Read More

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January 2021

Conservative Therapy for Peyronie's Disease: a Contemporary Review of the Literature.

Curr Urol Rep 2021 Jan 8;22(2). Epub 2021 Jan 8.

Department of Urology, Tulane University School of Medicine, 1430 Tulane Ave. 86-42, New Orleans, LA, 70112, USA.

Purpose Of Review: To analyze the literature on current conservative treatment options for Peyronie's disease (PD).

Recent Findings: Conservative therapy with intralesional collagenase clostridium histolyticum (CCH) is safe and efficacious in either the acute or chronic phases of PD. Combination treatment with penile traction therapy (PTT) can produce even better results. Read More

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January 2021

Role of neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios in Peyronie's disease: a new diagnostic approach to predict the stage of the disease?

Asian J Androl 2021 May-Jun;23(3):325-329

Department of Urology, Research Institute Hospital 12 de Octubre (Imas12), Madrid 29041, Spain.

Neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) have been associated with multiple entities and several types of cancers. They can be assumed as markers of inflammatory imbalance. The objective of this study is to evaluate the NLR and PLR in Peyronie's disease (PD) and to establish a comparison of its values in the acute and chronic stages. Read More

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December 2020

Peyronie Disease.

JAMA 2020 12;324(24):2566

New York Presbyterian Hospital-Weill Cornell Medicine, New York, New York.

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December 2020

Peyronie's Disease: What About the Female Sexual Partner?

Sex Med Rev 2021 Apr 17;9(2):230-235. Epub 2020 Dec 17.

Department of Urology, Kaiser Permanente Orange County Medical Center, Anaheim, CA.

Introduction: Peyronie's disease (PD) is an acquired wound-healing disorder of the penis involving fibrosis and scar formation within the tunica albuginea that can lead to various penile deformities resulting in penile pain, sexual dysfunction, low self-esteem, and emotional distress. While many studies highlight the psychosocial impact of PD on the patient, little is known about the female partner's experience regarding PD and its management.

Objectives: To evaluate and summarize the available clinical data on the effects of the disease and its management on female sexual partners of patients with PD. Read More

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Early penile-only metastasis of urothelial bladder carcinoma.

Future Sci OA 2020 Aug 24;6(10):FSO611. Epub 2020 Aug 24.

Department of Urology, Faculty of Medicine, Saint-Joseph University, Beirut, Lebanon.

Penile metastasis rarely occurs as a unique and early distant recurrence of urothelial bladder carcinoma. A 77-year-old male underwent a radical cystoprostatecomy for a pT3a urothelial bladder cancer. Preoperative imaging workup concluded to a disease confined to the bladder. Read More

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