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    1 OF 39

    Objective measurements of the penile angulation are significantly different than self-estimated magnitude among patients with penile curvature.
    Int Braz J Urol 2018 Mar 23;44. Epub 2018 Mar 23.
    Department of Urology, University of Trieste, Trieste, Italy.
    Introduction: The study was aimed to assess the presence of actual differences between the objective and the perceived magnitude of a curvature between patients affected by Peyronie's disease (PD) and congenital penile curvature (CPC).

    Materials And Methods: Wee analysed a cohort of 88 consecutive patients seeking medical help for either CPC or PD. All patients were invited to provide a self-made drawing of their penis in erection in order to obtain self-provided description of the deformity. Read More

    A Worldwide Survey on Peyronie's Disease Surgical Practice Patterns Among Surgeons.
    J Sex Med 2018 Mar 14. Epub 2018 Mar 14.
    Division of Urology, St Joseph's Health Care, London, ON, Canada.
    Background: Despite published guidelines on Peyronie's disease (PD), there are limited data on actual surgical practice among surgeons.

    Aim: To evaluate the surgical practice patterns in PD among surgeons from different continents and members of various sexual medicine societies.

    Methods: An anonymous survey on various pre-, intra-, and postoperative aspects of PD surgical care was distributed in printed format during International Society of Sexual Medicine meetings and as an online survey to International Society of Sexual Medicine members. Read More

    A Novel Non-Invasive Ultrasound Vibro-Elastography Technique for Assessing Patients with Erectile Dysfunction and Peyronie's Disease.
    Urology 2018 Mar 13. Epub 2018 Mar 13.
    Departments of Urology, Mayo Clinic, Rochester, MN 55905, USA.
    Introduction: Erectile dysfunction (ED) is a common condition that is characterized by progressive corporal smooth muscle fibrosis. There is currently no widely accepted methods to characterize the extent and severity of penile fibrosis.

    Aim: The purpose of this study is to translate a novel ultrasound vibro-elastography (UVE) technique for noninvasively measuring viscoelasticity of the penis. Read More

    Safety and feasibility of platelet rich fibrin matrix injections for treatment of common urologic conditions.
    Investig Clin Urol 2018 Jan 21;59(1):61-65. Epub 2017 Dec 21.
    Department of Urology, Wake Forest Baptist Medical Center, Winston Salem, NC, USA.
    Purpose: Autologous platelet rich plasma (PRP) is used increasingly in a variety of settings. PRP injections have been used for decades to improve angiogenesis and wound healing. They have also been offered commercially in urology with little to no data on safety or efficacy. Read More

    The PICS Technique: A Novel Approach for Residual Curvature Correction During Penile Prosthesis Implantation in Patients With Severe Peyronie's Disease Using the Collagen Fleece TachoSil.
    J Sex Med 2018 Mar 8;15(3):416-421. Epub 2018 Jan 8.
    Department of Urology and Pediatric Urology, Julius Maximilians University of Würzburg, Würzburg, Germany. Electronic address:
    Background: Correction of residual curvature during inflatable penile prosthesis (IPP) implantation in patients with Peyronie's disease (PD) by plaque incision and grafting is a common approach.

    Aim: To present a novel technique for residual curvature correction during IPP implantation using collagen fleece (TachoSil, Baxter Healthcare Corp, Deerfield, IL, USA).

    Methods: After the IPP (Titan Touch, Coloplast, Minneapolis, MN, USA) is placed, the implant is inflated maximally. Read More

    The Multiple-Slit Technique (MUST) for Penile Length and Girth Restoration.
    J Sex Med 2018 Feb 21;15(2):261-269. Epub 2017 Dec 21.
    Private Practice, Vienna, Austria. Electronic address:
    Background: Patients with severe erectile dysfunction (ED) and penile size issues, especially seen in Peyronie's disease (PD), are candidates for more invasive penile prosthesis insertion techniques that aim for penile length and girth reconstruction.

    Aim: To present the feasibility and safety of penile length and girth restoration based on the so-called multiple-slit technique (MUST) for patients with severe ED and significant penile shortening with or without PD.

    Methods: From July 2013 through January 2016, 138 patients underwent the MUST. Read More

    Grafts for Peyronie's disease: a comprehensive review.
    Andrology 2018 Jan 20;6(1):117-126. Epub 2017 Dec 20.
    Department of Urology, 12 de Octubre University Hospital, Madrid, Spain.
    The difficulty implicit in combining all the characteristics that an ideal patch to treat Peyronie's disease with a lengthening procedure should have, together with the challenges of comparing results from different series, means that the ideal patch has yet to be determined. Our objective with this review was to determine whether any given patch type is preferable to the others based on the evaluation of the results of published studies. A systematic search of the literature was conducted from PubMed until December 2016. Read More

    [Cavernous metastasis from blader tumor].
    Pan Afr Med J 2017 21;28:60. Epub 2017 Sep 21.
    Université Mohammed 5, Faculté de Médecine et de Pharmacie de Rabat, Hopital Ibn Sina, Service d'Urologie B, Maroc.
    The incidence of cavernous metastases after radical treatment for bladder tumor is exceptional and is approximately 1%. The mean time between surgery and the occurrence of metastases is 8 months. In some cases they occur after 10 years. Read More

    Compounding Opportunities in Urology.
    Int J Pharm Compd 2017 Sep-Oct;21(5):358-362
    Professional Compounding Centers of America, Houston, Texas.
    There are a lot of options that pharmacists, including compounding pharmacists, can offer urologists to assist their patients. Compounding pharmacists are in a great position to offer unique, effective preparations for many of the conditions urologists treat on a daily basis. It would be well worth the time to learn a little about the conditions these specialists treat and become familiar with what you can offer. Read More

    Inhibition of penile tunica albuginea myofibroblasts activity by adipose-derived stem cells.
    Exp Ther Med 2017 Nov 21;14(5):5149-5156. Epub 2017 Sep 21.
    Department of Andrology, Drum Tower Hospital, Affiliated to School of Medicine, Nanjing University, Nanjing, Jiangsu 210008, P.R. China.
    The activation of tunica albuginea myofibroblasts (MFs) serves an essential role in Peyronie's disease (PD). Increasing evidence has reported that adipose tissue-derived stem cells (ADSCs) have been demonstrated to attenuate the symptoms of PD in animal models. However, the mechanisms of the antifibrotic effects of ADSCs in PD remain to be fully elucidated. Read More

    Surgical correction of Peyronie's disease via tunica albuginea plication: long-term follow-up.
    Andrology 2018 Jan 1;6(1):47-52. Epub 2017 Dec 1.
    Department of Urology, Humanitas Mater Domini, Castellanza, Italy.
    Peyronie's disease (PD) is an acquired connective tissue disorder of the tunica albuginea with fibrosis and inflammation that lead to palpable plaques formation, penile curvature, and pain during erection. Patients report negative effects on main domains such as physical appearance and self-image, sexual function, and performance. The aim of this study was to evaluate plication of the albuginea outcomes after a long-term follow-up period. Read More

    Defining a glycated haemoglobin (HbA1c) level that predicts increased risk of penile implant infection.
    BJU Int 2018 02 1;121(2):293-300. Epub 2017 Dec 1.
    Sexual and Reproductive Medicine Program, Urology Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
    Objectives: To re-evaluate the role of diabetes mellitus (DM) as a risk factor for penile implant infection by exploring the association between glycated haemoglobin (HbA1c) levels and penile implant infection rates and to define a threshold value that predicts implant infection.

    Patients And Methods: We conducted a multicentre prospective study including all patients undergoing penile implant surgery between 2009 and 2015. Preoperative, perioperative and postoperative management were identical for the entire cohort. Read More

    Penile metastasis from rectal adenocarcinoma: a case report.
    BMC Res Notes 2017 Nov 6;10(1):564. Epub 2017 Nov 6.
    Department of Pathology, Hassan II University Hospital, Fès, Morocco.
    Background: Despite its rich vasculature, the penis is rarely involved by metastasis. Since the first description of penile metastasis in 1870, fewer than 500 cases have been reported in the literature. The pelvic organs are the main source of primary tumors that metastasize to the penis. Read More

    Complications of penile self-injections: investigation of 680 patients with complications following penile self-injections with mineral oil.
    World J Urol 2018 Jan 28;36(1):135-143. Epub 2017 Oct 28.
    Urological Research Center (URC), Department of Urology, Lillebaelt Hospital, Fredericia, Denmark.
    Objective: Penile implants and injection of foreign materials have been described in texts like Kama Sutra for more than 1500 years, and are still being practiced around the world. The extent of this practice is unknown, and the documentation available today only scratches the surface. This study investigates and documents the complications after penile self-injections at the Mae Tao Clinic. Read More

    [Diagnostic value of high-field MRI for Peyronie's disease].
    Zhonghua Nan Ke Xue 2016 Sep;22(9):787-791
    Department of Ultrasonography, The First Hospital Affiliated to Sun Yat-sen University, Guangzhou, Guangdong 510080, China.
    Objective: To analyze the MRI manifestations of Peyronie's disease and investigate the value of high-field MRI in the diagnosis of the disease.

    Methods: Using a small surface coil, we performed 3.0 Tesla MRI for 14 patients with clinically diagnosed Peyronie's disease. Read More

    [Buccal mucosa transplant the concept of ideal graft in surgical management of peyronies disease].
    Urologiia 2017 Sep(4):68-72
    N.I. Pirogov RNRMU of Minzdrav of Russia, Moscow, Russia.
    Introduction: Surgical techniques in managing Peyronies disease include plication corporoplasty, plaque incision, grafting and penile prosthesis implantation. The question of an ideal transplant for corporoplasty remains open.

    Aim: To evaluate the effectiveness of the substitution corporoplasty using buccal mucosa transplant (BMT) in treating Peyronies disease. Read More

    Successful Treatment of Residual Curvature in Peyronie Disease in Men Previously Treated With Intralesional Collagenase Clostridium Histolyticum.
    Urology 2017 Dec 5;110:110-113. Epub 2017 Sep 5.
    Department of Urology, Tulane University School of Medicine, New Orleans, LA. Electronic address:
    Objective: To determine the success and feasibility of surgically correcting residual curvature after intralesional collagenase clostridium histolyticum (CCH) for the treatment of Peyronie disease (PD).

    Methods: We performed a retrospective analysis of patients who had intralesional CCH treatment for PD and who subsequently underwent penile plication (PP), plaque incision and grafting (PIG), or inflatable penile prosthesis (IPP) placement.

    Results: Ten men who underwent PP, PIG, or IPP for the treatment of residual curvature after intralesional CCH were identified. Read More

    Collagenase Clostridium Histolyticum in the Treatment of Peyronie's Disease: Review of a Minimally Invasive Treatment Option.
    World J Mens Health 2017 Dec 6;35(3):134-145. Epub 2017 Sep 6.
    Department of Urology, Tulane University School of Medicine, New Orleans, LA, USA.
    Peyronie's disease (PD) is an inflammatory disorder characterized by an abnormal collagen deposition in the tunica albuginea of the penis, leading to fibrous and non-compliant plaques that can impede normal erection. Although pharmacological treatments are available, only intralesional injection therapy and surgical reconstruction have demonstrated tangible clinical efficacy in the management of this condition. Intralesional injection of collagenase clostridium histolyticum (CCH) has come to the forefront of minimally invasive treatment of PD. Read More

    Collagenase Clostridium histolyticum in the Treatment of Peyronie's Disease-A Review of the Literature and a New Modified Protocol.
    Sex Med Rev 2017 Oct 2;5(4):529-535. Epub 2017 Sep 2.
    Andrology Department, The Institute of Urology and University College London Hospital, London, UK.
    Introduction: Peyronie's disease (PD) is a common condition that results in penile deformity, which makes sexual intercourse difficult or impossible, and causes psychological, emotional, and relationship difficulties for the man affected and his partner. Collagenase Clostridium histolyticum (CCH; Xiapex, Xiaflex) is the first licensed non-surgical treatment option for PD. The safety and efficacy have been demonstrated in two large phase III randomized controlled trials (IMPRESS I and IMPRESS II). Read More

    Dupuytren-Like Contracture of the Foot: Ledderhose Disease.
    Surg J (N Y) 2016 Jul 21;2(3):e102-e104. Epub 2016 Sep 21.
    Department of Plastic, Reconstructive, and Aesthetic Surgery, Selcuk University Medical Faculty, Konya, Turkey.
     Plantar fibromatosis is a rare hyperproliferative disease of plantar aponeurosis and is also called Ledderhose disease. Case properties and treatment are discussed in this report. A 30-year-old man presented with painful bilateral plantar nodules. Read More

    Penile Doppler ultrasonography revisited.
    Ultrasonography 2018 Jan 10;37(1):16-24. Epub 2017 Jun 10.
    Department of Urology and Urological Science Institute, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
    Penile Doppler ultrasonography is a high-performing, noninvasive or minimally-invasive imaging modality that allows the depiction of the normal anatomy and macroscopic pathologic changes in real time. Moreover, functional changes in penile blood flow, as seen in erectile dysfunction (ED), can be analyzed using color Doppler ultrasonography (CDUS). This review article describes the normal sonographic anatomy of the penis, the sonographic technique for evaluating ED, the normal phases of erection, and the various causes of ED. Read More

    An unanswered question in pediatric urology: the post pubertal persistence of prepubertal congenital penile curvature correction by tunical plication.
    Int Braz J Urol 2017 Sep-Oct;43(5):925-931
    Department of Urology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
    Objective: The aim of this study is to analyze post pubertal results of pre pubertal tunica albuginea plication with non-absorbable sutures in the correction of CPC.

    Materials And Methods: The files of patients who underwent tunica albuginea plication without incision (dorsal/lateral) were retrospectively reviewed. Patients younger than 13 years of age at the time of operation and older than 14 years of age in November 2015 were included. Read More

    Extracellular matrix alterations in the Peyronie's disease.
    J Adv Res 2017 Jul 15;8(4):455-461. Epub 2017 Jun 15.
    Biochemistry Departament, Faculdade de Medicina do ABC, Santo André 09060-650, Brazil.
    Peyronie's disease is characterized by fibrous plaque formation of the tunica albuginea, causing penile deformity and fertility problems. The aim of the present study was to investigate alterations in the extracellular matrix in Peyronie's disease. The study used tissues collected by surgical procedure from individuals that presented a well-established disease, while control samples were obtained by biopsies of fresh cadavers. Read More

    Evaluation of intralesional injection of hyaluronic acid compared with verapamil in Peyronie's disease: preliminary results from a prospective, double-blinded, randomized study.
    Andrology 2017 07;5(4):771-775
    Urology Section, Department of Surgery, University of Catania, Catania, Italy.
    Several intralesional therapeutic protocols have been proposed for the treatment of Peyronie's disease. Among all, hyaluronic acid (HA) and verapamil have been differently tested. We aimed to evaluate the efficacy of intralesional verapamil (ILVI) compared with intralesional HA in patients with early onset of Peyronie's disease (PD). Read More

    Penile Plication With or Without Degloving of the Penis Results in Similar Outcomes.
    Sex Med 2017 Sep 13;5(3):e142-e147. Epub 2017 Jul 13.
    Department of Urology, Uludag University, School of Medicine, Bursa, Turkey.
    Background: Penile plication techniques with or without degloving offer a minimally invasive option for the treatment of penile curvature.

    Aim: To review the outcomes of penile plication surgery and patient satisfaction with and without degloving of the penis.

    Methods: We conducted a retrospective analysis of 52 patients who underwent penile plication for the treatment of Peyronie disease or congenital penile curvature. Read More

    Prevalence of Peyronie's Disease-Like Symptoms in Men Presenting With Dupuytren Contractures.
    Sex Med 2017 Sep 1;5(3):e135-e141. Epub 2017 Jul 1.
    Department of Orthopaedic Surgery, University of California-Davis, Sacramento, CA, USA.
    Introduction: Peyronie's disease (PD) and Dupuytren contractures (DC) are often comorbid and are believed to have a similar underlying pathophysiologic mechanism.

    Aim: To investigate the prevalence of PD-like symptoms (PDLS) in men with DC.

    Methods: From October 2013 to December 2016, men who were seen and evaluated for DC were offered the opportunity to participate in an anonymous survey. Read More

    Safety and effectiveness of collagenase clostridium histolyticum in the treatment of Peyronie's disease using a new modified shortened protocol.
    BJU Int 2017 11 14;120(5):717-723. Epub 2017 Jul 14.
    Andrology Department, University College London Hospital and The Institute of Urology London and St Peter's Andrology Centre, London, UK.
    Objectives: To evaluate the efficacy and safety of collagenase clostridium histolyticum (CCH; Xiapex, Xiaflex) in the treatment of Peyronie's disease (PD) using a new modified treatment protocol that aims at reducing the number of injections needed and reducing patient visits, thus reducing the duration and cost of treatment.

    Patients And Methods: A prospective study of 53 patients with PD who had treatment with CCH at a single centre using a new modified protocol. The angle of curvature assessment after an intracavernosal injection of prostaglandin E1, the International Index of Erectile Function (IIEF) and Peyronie's Disease Questionnaire (PDQ) were completed at baseline and at week 12 (4 weeks after the last injection). Read More

    Association of the modified frailty index with adverse outcomes after penile prosthesis implantation.
    Aging Male 2017 Jun 28;20(2):119-124. Epub 2017 Feb 28.
    b Division of Urology , Department of Surgery, Faculty of Medicine, King Saud University , Riyadh , Saudi Arabia , and.
    Objectives: To investigate frailty as a predictor of surgical outcome in elderly patients undergoing penile prosthesis implantation.

    Material And Methods: A total of 54 elderly patients, above 60 years of age, underwent penile prosthesis implantation between 2012 and 2014. Their data were collected and retrospectively analyzed. Read More

    Factors Associated With Erectile Dysfunction and the Peyronie's Disease Questionnaire in Patients With Peyronie Disease.
    Urology 2017 Sep 26;107:155-160. Epub 2017 May 26.
    Tulane University Health Sciences Center, New Orleans, LA.
    Objective: To elucidate patient characteristics that impact symptom-related bother and erectile function in patients with Peyronie disease (PD).

    Methods: A post hoc analysis used data from patients with PD (ie, had PD symptoms ≥12 months and penile curvature deformity of 30-90 degrees) who received ≥1 injection of study medication in 2 phase 3 trials of collagenase clostridium histolyticum (Investigation for Maximal Peyronie's Reduction Efficacy and Safety Study I [n = 417] and Investigation for Maximal Peyronie's Reduction Efficacy and Safety Study II [n = 415]). The Covariance Analysis of Linear Structural Equations procedure was used to estimate the potential relationship of specified variables on the level of distress and erectile dysfunction associated with PD as measured by the Peyronie's Disease Questionnaire and the International Index of Erectile Function, erectile function domain. Read More

    A new technique, combined plication-incision (CPI), for correction of penile curvature.
    Int Braz J Urol 2018 Jan-Feb;44(1):180-187
    Department of Andrology, Faculty of Medicine, Cairo University, Cairo, Egypt.
    Introduction: Penile curvature (PC) can be surgically corrected by either corporoplasty or plication techniques. These techniques can be complicated by post-operative: penile shortening, recurrent PC, painful/palpable suture knots and erectile dysfunction.

    Objective: To avoid the complications of corporoplasty and plication techniques using a new technique: combined plication-incision (CPI). Read More

    Penile ossification: A reconstructive challenge.
    Rev Urol 2017 ;19(1):64-67
    Department of Urology, University of Texas Southwestern Medical CenterDallas, TX.
    Penile ossification is a rare condition that occurs most commonly in acquired cases of penile deformity. We report the case of a 43-year-old man with Peyronie disease who was incidentally found to have significant ossified tissue in his penile corpora during complex placement of an inflatable penile prosthesis (IPP). His clinical course was later complicated by impending distal extrusion of his IPP laterally, necessitating corporoplasty. Read More

    [Penile Tuberculosis : A Case Report].
    Hinyokika Kiyo 2017 Apr;63(4):163-167
    The Department of Infection Control Team, Osaka Police Hospital.
    A 66-year-old man presented with a chief complaint of glans penis pain, induration, and discharge of pus. He was prescribed a course of antibiotics, but the condition persisted despite treatment. Thus, we differrentially diagnosed the patient with penile tuberculosis and pyoderma gangrenosum, and performed a biopsy of the penis. Read More

    Safety Profile of Collagenase Clostridium Histolyticum Stratified by Degree of Penile Curvature in Patients With Peyronie Disease.
    Urology 2017 Aug 10;106:237.e9-237.e14. Epub 2017 May 10.
    Endo Pharmaceuticals Inc., Malvern, PA.
    Objective: To examine the safety of collagenase clostridium histolyticum (CCH) in adult men with penile curvature deformity <30°. CCH is indicated for treatment of Peyronie disease in adult men with palpable plaque and a penile curvature deformity ≥30° at start of therapy; however, during treatment, patients may receive CCH injections when penile curvature deformity is <30°.

    Materials And Methods: Patients who received ≥2 CCH treatment cycles in 2 phase 3 studies (Investigation for Maximal Peyronie's Reduction Efficacy and Safety Studies I and II) were included. Read More

    Self-reported Clinical Meaningfulness Early in the Treatment Course Predicts Objective Outcomes in Men Undergoing Collagenase Clostridium histolyticum Injections for Peyronie Disease.
    Urology 2017 Aug 5;106:107-112. Epub 2017 May 5.
    Department of Urology, Mayo Clinic, Rochester, MN. Electronic address:
    Objective: To compare perceived meaningfulness early in the course of collagenase Clostridium histolyticum (CCH) with final outcomes to evaluate its use as a predictor of efficacy.

    Materials And Methods: A registry of patients undergoing CCH from March 2014 to September 2016 was maintained. Patients were recommended to complete 4 injection cycles. Read More

    Three-Dimensional Photography for Quantitative Assessment of Penile Volume-Loss Deformities in Peyronie's Disease.
    J Sex Med 2017 Jun 28;14(6):829-833. Epub 2017 Apr 28.
    Department of Urology, Columbia University College of Physicians and Surgeons, New York, NY, USA.
    Background: Non-curvature penile deformities are prevalent and bothersome manifestations of Peyronie's disease (PD), but the quantitative metrics that are currently used to describe these deformities are inadequate and non-standardized, presenting a barrier to clinical research and patient care.

    Aim: To introduce erect penile volume (EPV) and percentage of erect penile volume loss (percent EPVL) as novel metrics that provide detailed quantitative information about non-curvature penile deformities and to study the feasibility and reliability of three-dimensional (3D) photography for measurement of quantitative penile parameters.

    Methods: We constructed seven penis models simulating deformities found in PD. Read More

    Collagenase Clostridium Histolyticum in the Treatment of Urologic Disease: Current and Future Impact.
    Sex Med Rev 2018 Jan 25;6(1):143-156. Epub 2017 Apr 25.
    Department of Urology, Tulane University School of Medicine, New Orleans, LA, USA. Electronic address:
    Introduction: Peyronie's disease (PD) is a connective tissue disorder resulting in the abnormal accumulation of type I to III collagen, fibrin, and disorganized elastic fibers in the tunica albuginea of the penis. Many medical and non-pharmacologic modalities have been used in the treatment of PD; however, these approaches have proved largely ineffective, with surgery being the only definitive treatment. Intralesional injection of collagenase Clostridium histolyticum (CCH) has recently become the gold standard for minimally invasive treatment of PD, and studies have suggested the role of CCH could expand to the treatment of other urologic conditions such as urethral stricture disease. Read More

    Changes in the Effects of Peyronie's Disease After Treatment With Collagenase Clostridium histolyticum: Male Patients and Their Female Partners.
    Sex Med 2017 Jun 5;5(2):e124-e130. Epub 2017 Apr 5.
    Australian Centre for Sexual Health, St Leonards, NSW, Australia.
    Introduction: Collagenase Clostridium histolyticum (CCH) intralesional injection was efficacious for the management of Peyronie's disease (PD) in the double-blinded, randomized, placebo-controlled Investigation for Maximal Peyronie's Reduction Efficacy and Safety Studies I and II (IMPRESS I and II). Little is known about the consequences of PD or treatment on the sexual partners of affected men.

    Aim: To assess the safety and efficacy of CCH treatment in men who received placebo in the IMPRESS I or II study and to evaluate the men's PD symptoms and partner bother as reported by female sexual partners. Read More

    Role of interleukin-6 and pentraxin 3 as an early marker in Peyronie's disease.
    Kaohsiung J Med Sci 2017 Apr 28;33(4):195-200. Epub 2017 Feb 28.
    Department of Urology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, Istanbul, Turkey.
    Inflammation is mechanistically involved in the development of Peyronie's disease (PD). The aim of this study is to assess the relevance of serum pentraxin 3 (PTX3) and interleukin-6 (IL-6) concentrations in PD. The study enrolled 40 patients with PD in the acute phase and 40 healthy controls. Read More

    Clinical Experience With Penile Traction Therapy Among Men Undergoing Collagenase Clostridium histolyticum for Peyronie Disease.
    Urology 2017 Jun 24;104:102-109. Epub 2017 Mar 24.
    Department of Urology, Mayo Clinic, Rochester, MN. Electronic address:
    Objective: To evaluate the outcomes in men undergoing collagenase Clostridium histolyticum (CCH) with concurrent penile traction therapy (PTT) for the treatment of Peyronie disease (PD).

    Materials And Methods: We identified patients treated with CCH between March 2014 and July 2016. Patients were recommended to perform modeling and PTT between injection series. Read More

    Stem cell therapy for the treatment of Peyronie's disease.
    Expert Opin Biol Ther 2017 04 28;17(4):407-413. Epub 2017 Feb 28.
    a University Department of Urology , Sismanoglio General Hospital , Athens , Greece.
    Introduction: Like other fibrotic diseases, the cause of Peyronie's disease (PD) is still obscure. Since there is now increasing evidence for the role of Mesenchymal Stem Cells (MSCs) as potential treatment to fibrosis, it is crucial to determine their possible efficacy in the treatment of PD. Areas covered: In this review, the authors summarize the emerging data and published studies regarding the use of SCs for the treatment of PD. Read More

    Low-Intensity Extracorporeal Shockwave Therapy in Sexual Medicine: A Questionnaire-Based Assessment of Knowledge, Clinical Practice Patterns, and Attitudes in Sexual Medicine Practitioners.
    Sex Med 2017 Jun 6;5(2):e94-e98. Epub 2017 Mar 6.
    Department of Urology, Amstelland Hospital, Amstelveen, The Netherlands.
    Introduction: Low-intensity extracorporeal shockwave therapy (LI-ESWT) has emerged as a treatment option for male sexual dysfunction. However, results have been contradictory.

    Aim: To investigate the knowledge, practice patterns, and attitudes regarding LI-ESWT among experts in sexual medicine. Read More

    Sexual Rehabilitation After Treatment For Prostate Cancer-Part 2: Recommendations From the Fourth International Consultation for Sexual Medicine (ICSM 2015).
    J Sex Med 2017 Mar;14(3):297-315
    Scott Department of Urology, Baylor College of Medicine, Houston, TX, USA.
    Introduction: Sexual dysfunction is common in patients after radical prostatectomy (RP) for prostate cancer.

    Aim: To provide the International Consultation for Sexual Medicine (ICSM) 2015 recommendations concerning management strategies for post-RP erectile function impairment and to analyze post-RP sexual dysfunction other than erectile dysfunction.

    Methods: A literature search was performed using Google and PubMed database for English-language original and review articles published up to August 2016. Read More

    Contemporary Review of Grafting Techniques for the Surgical Treatment of Peyronie's Disease.
    Sex Med Rev 2017 Oct 1;5(4):544-552. Epub 2017 Mar 1.
    Department of Urology, University of California-Irvine, Irvine, CA, USA.
    Introduction: Peyronie's disease (PD) is a benign fibrotic disorder of the tunica albuginea of the penis, which can cause penile pain, curvature, shortening, erectile dysfunction, and psychological distress. Surgery is indicated when penile curvature prevents satisfactory sexual intercourse. Plaque incision or excision with grafting has been suggested as an option in patients with a penile curvature greater than 60°, a shortened penis, and/or an hourglass or complex deformity. Read More

    Survey of patient and partner satisfaction following collagenase Clostridium histolyticum treatment for Peyronie's disease.
    Andrology 2017 03 10;5(2):274-277. Epub 2017 Feb 10.
    Department of Urology, Tulane University School of Medicine, New Orleans, LA, USA.
    Intralesional injection of collagenase Clostridium histolyticum (CCH) is a minimally invasive, Food and Drug Administration-approved, effective treatment for Peyronie's disease (PD). To assess the satisfaction of patients and their female sexual partners (FSP) following CCH therapy for PD, we conducted a retrospective review of the records of all patients treated with CCH for PD between 04/2014 and 03/2016. Collected variables included demographics, pre- and post-treatment sexual function, penile curvature, penile vascular findings, and treatment outcomes. Read More

    Role of extracorporeal shock wave therapy in management of Peyronie's disease: A preliminary report.
    Urol Ann 2016 Oct-Dec;8(4):409-417
    Department of Urology and Genito-Urinary Surgery, Ruby Hall Clinic, Pune, Maharashtra, India.
    Introduction: Peyronie's Disease (PD) is a disease causing psycho social trauma to the patient. Multiple treatment options are available with variable results. Extra Corporeal Shock Wave Therapy (ESWT) is a new insight into the non invasive modality of management. Read More

    Stem Cells in Male Sexual Dysfunction: Are We Getting Somewhere?
    Sex Med Rev 2017 Apr 29;5(2):222-235. Epub 2016 Dec 29.
    Laboratory of Experimental Urology, Department of Development and Regeneration, KU Leuven, Leuven, Belgium. Electronic address:
    Introduction: Stem cells for sexual disorders are steadily being introduced into clinical trials. Two conditions of importance are the main target for this line of treatment, especially when regarding the wide array of translational and basic science highlighting the potential advantages of regenerative therapy: erectile dysfunction (ED) and more recently Peyronie disease (PD). Cellular therapy offers a treatment modality that might reverse disease progression. Read More

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