2,026 results match your criteria Peyronie Disease


Pathophysiology and Future Therapeutic Perspectives for Resolving Fibrosis in Peyronie's Disease.

Sex Med Rev 2019 Apr 5. Epub 2019 Apr 5.

Laboratory of Experimental Urology, Department of Development and Regeneration, University of Leuven, Leuven, Belgium; Department of Urology, University Hospitals of Leuven, Leuven, Belgium. Electronic address:

Introduction: Peyronie's disease (PD) is a debilitating affliction for the male population, causing severe curvatures to the erect penis and erectile dysfunction in about 50% of men. This deviation of the penis significantly impairs sexual intercourse and causes depression and strains in the relationship. As of today, medical treatment options are few and far between, with surgery remaining as the sole reliable treatment. Read More

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http://dx.doi.org/10.1016/j.sxmr.2019.02.004DOI Listing

Efficacy of Combined Collagenase Clostridium histolyticum and RestoreX Penile Traction Therapy in Men with Peyronie's Disease.

J Sex Med 2019 Apr 4. Epub 2019 Apr 4.

Department of Urology, Mayo Clinic, Rochester, MN, USA. Electronic address:

Background: Previous studies of penile traction therapy (PTT) devices have demonstrated limited/no efficacy when combined with intralesional therapies for Peyronie's disease (PD). Recently, randomized data have demonstrated the efficacy of a novel PTT device, RestoreX, developed in cooperation with the Mayo Clinic, in men with PD.

Aim: To assess the safety and efficacy of treatment with the RestoreX device plus collagenase Clostridium histolyticum (CCH) compared with CCH alone and CCH with other PTT devices. Read More

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http://dx.doi.org/10.1016/j.jsxm.2019.03.007DOI Listing
April 2019
1 Read

Extracorporeal Shock Wave Therapy in Peyronie's Disease: Clinical Efficacy and Safety from a Single-Arm Observational Study.

World J Mens Health 2019 Mar 26. Epub 2019 Mar 26.

Department of Urology, University of Florence, Florence, Italy.

Purpose: In this study, we aimed to determine the role of extracorporeal shockwave therapy (ESWT) in the management of Peyronie's disease (PD).

Materials And Methods: A total of 325 patients suffering from PD were enrolled in this single-arm clinical study. All patients were received ESWT using a schedule of 1 treatment/wk. Read More

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http://dx.doi.org/10.5534/wjmh.180100DOI Listing
March 2019
1 Read

A Comparison of Hemostatic Patches versus Pericardium Allograft for the Treatment of Complex Peyronie's Disease with Penile Prosthesis and Plaque Incision.

Urology 2019 Mar 23. Epub 2019 Mar 23.

Division of Urology, Rush University Medical Center, 1725 West Harrison Street, Suite 348, Chicago, IL, 60612. Electronic address:

Objectives: To compare outcomes between hemostatic patches (HP) versus pericardium allografts (PA) for complex Peyronie's disease with erectile dysfunction managed with inflatable penile prosthesis (IPP) and plaque incision and grafting (PIG).

Methods: We reviewed all men who underwent IPP with PIG for PD at our institution (4/2010-9/2018). PIG was performed via relaxing tunical incisions during IPP implantation following manual modeling if there was persistent curve >30 and/or significant narrowing. Read More

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http://dx.doi.org/10.1016/j.urology.2019.03.008DOI Listing
March 2019
2 Reads

Supporting the role of penile trauma and micro-trauma in the etiology of Peyronie's disease. Prospective observational study using the electronic microscope to examine two types of plaques.

Aging Male 2019 Mar 16:1-6. Epub 2019 Mar 16.

a Department of Urology, Policlinico San Martino Hospital , University of Genova , Genova , Italy.

Objectives: The etiopathogenesis of Peyronie's disease (PD) remains not clearly understood. The most accepted theory attributes the histological lesions of PD to the effects of trauma to the corpora cavernosum of the penis. The aim of our study is to verify whether similar histological features exist between these two tissues, providing new evidence in favor of the traumatic theory in the etiopathogenesis of Peyronie's disease. Read More

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http://dx.doi.org/10.1080/13685538.2019.1586870DOI Listing

Innovating Incrementally: Development of the Modern Inflatable Penile Prosthesis.

Curr Urol Rep 2019 Mar 7;20(4):17. Epub 2019 Mar 7.

University of North Carolina-Chapel Hill, 2105 Physician's Office Building, 170 Manning Drive, Chapel Hill, NC, 27599, USA.

Purpose Of Review: The inflatable penile prosthesis (IPP) was introduced in 1973. Since that time, the fundamental design of the IPP has not changed, but numerous improvements to the device, surgery, and peri-operative management have resulted in a modern IPP with excellent reliability, infection control, safety profile, and user experience.

Recent Findings: We describe important modifications to the IPP and review available data assessing the impact of these changes. Read More

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http://link.springer.com/10.1007/s11934-019-0880-x
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http://dx.doi.org/10.1007/s11934-019-0880-xDOI Listing
March 2019
6 Reads

Administration of Adipose Derived Mesenchymal Stem Cells and Platelet Lysate in Erectile Dysfunction: A Single Center Pilot Study.

Bioengineering (Basel) 2019 Mar 5;6(1). Epub 2019 Mar 5.

2nd Urological Department, Medical School of Athens, National and Kapodistrian University, 12462 Athens, Greece.

Erectile dysfunction (ED) affects more than 30 million men; endothelial dysfunction plays a significant role in EDs pathogenesis. The aim of this study was to administer mesenchymal stem cells (MSC) derived from adipose tissue and platelet lysate (PL) into patients with erectile dysfunction. This pilot study enrolled eight patients with diagnosed ED. Read More

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http://dx.doi.org/10.3390/bioengineering6010021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466012PMC

Ten-year experience with multimodal treatment for acute phase Peyronie's disease: A real life clinical report.

Actas Urol Esp 2019 Jan 28. Epub 2019 Jan 28.

Gallo Uro-Andrology Centre, Nápoles, Italia.

Objectives: To present our experience with multimodal therapy for Peyronie's disease.

Methods: Retrospective data were collected since 2008 to 2017. The following features were evaluated at baseline and after treatment: age, duration of disease, erectile function, erected penile curvature, and stretched penile length. Read More

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http://dx.doi.org/10.1016/j.acuro.2018.08.005DOI Listing
January 2019

A Contemporary Evaluation of Peyronie's Disease During Penile Prosthesis Placement: MOST, MUST, and More.

Curr Urol Rep 2019 Jan 30;20(2). Epub 2019 Jan 30.

Division of Urology and Urologic Oncology, City Of Hope, 1500 East Duarte Ave, Duarte, CA, 91010, USA.

Purpose Of Review: The use of penile implant for the treatment of both erectile dysfunction and Peyronie's disease has changed little in the last 40 years, primarily limited to modeling and plaque incision. In the current review, I explore the history of Peyronie's treatment at the time of penile prosthesis placement and explore new surgical options that help resolve several of the issues that were not treated with the traditional approaches.

Recent Findings: Advancements have been made in the area of graft material, lengthening procedures, and transcorporal techniques. Read More

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http://dx.doi.org/10.1007/s11934-019-0870-zDOI Listing
January 2019
2 Reads

Intralesional Collagenase Clostridium histolyticum Causes Meaningful Improvement in Men with Peyronie's Disease: Results of a Multi-Institutional Analysis.

J Urol 2019 Apr;201(4):777-782

Department of Urology, University of California-Los Angeles , Los Angeles , California.

Purpose: In a multi-institutional setting we studied the efficacy and safety outcomes at multiple high volume centers where collagenase Clostridium histolyticum is used to treat Peyronie's disease.

Materials And Methods: We collected retrospective data on consecutive patients with Peyronie's disease who underwent treatment with collagenase C. histolyticum between April 2014 and March 2018 at a total of 5 institutions. Read More

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http://dx.doi.org/10.1097/JU.0000000000000032DOI Listing
April 2019
15 Reads

The prevalence of Peyronie's disease in diabetic patients -2018- Yazd.

Diabetes Metab Syndr 2019 Jan - Feb;13(1):604-607. Epub 2018 Nov 13.

Diabetes Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Electronic address:

Introduction: Peyronie's disease (PD) is the fibrous scar tissue inside the penis that causes curved and painful erections. PD is associated with, diabetes, hypertension, dyslipidemia and low testosterone. PD causes erectile dysfunction (ED). Read More

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http://dx.doi.org/10.1016/j.dsx.2018.11.039DOI Listing
November 2018
1 Read

Urologic conditions associated with malignancy.

Urol Oncol 2019 Jan 2. Epub 2019 Jan 2.

Division of Urology, Department of Surgery, University of Utah School of Medicine, Salt Lake City, UT. Electronic address:

Introduction: Recent advances in cancer research have highlighted the role of genetics in malignancy. Genetic dysregulation of core cellular functions similarly influences benign conditions. These common genetic factors have led researchers to identify an association between certain urologic conditions and malignancy. Read More

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http://dx.doi.org/10.1016/j.urolonc.2018.12.018DOI Listing
January 2019
3 Reads

The Impact of Clostridium Histolyticum Collagenase on the Prevalence and Management of Peyronie's Disease in the United States.

World J Mens Health 2019 May 30;37(2):234-239. Epub 2018 Nov 30.

Department of Urology, Stanford University, Stanford, CA, USA.

Purpose: We evaluated the impact of collagenase clostridium histolyticum (CCH) on rates of diagnosis, treatment, and corporal rupture in Peyronie's disease (PD). We examined the impact of CCH on cost of PD treatment.

Materials And Methods: We extracted data on PD diagnosis (ICD-9 607. Read More

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http://dx.doi.org/10.5534/wjmh.180073DOI Listing

Simvastatin and the Rho-kinase inhibitor Y-27632 prevent myofibroblast transformation in Peyronie's disease-derived fibroblasts via inhibition of YAP/TAZ nuclear translocation.

BJU Int 2019 Apr 6;123(4):703-715. Epub 2019 Jan 6.

Laboratory of Experimental Urology, Department of Development and Regeneration, KU Leuven, Leuven, Belgium.

Objectives: To uncover the anti-myofibroblast (MFB) properties of Rho-kinase inhibitor (compound Y-27632) and simvastatin in an in vitro model of Peyronie's disease (PD), a sexually debilitating disease caused by an irreversible fibrotic plaque in the penile tunica albuginea (TA).

Materials And Methods: Primary human fibroblasts (FBs) were isolated from surgically obtained TA tissue from patients with PD. To induce MFB status, cells were stimulated with 3 ng/mL transforming growth factor-β1 (TGF-β1). Read More

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http://dx.doi.org/10.1111/bju.14638DOI Listing
April 2019
1 Read

What about the partner? -factors associated with patient-perceived partner dyspareunia in men with Peyronie's disease.

Transl Androl Urol 2018 Dec;7(6):935-940

Department of Urology, Mayo Clinic, Rochester, MN, USA.

Background: Limited data are available on how partners of men with Peyronie's disease (PD) are affected by the disease. We sought to characterize PD patients whose curvatures result in pain for their partners during penetrative intercourse.

Methods: We queried a database of all men undergoing initial evaluation for PD at a single clinic between March 2014 and June 2016. Read More

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http://dx.doi.org/10.21037/tau.2018.07.20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6256043PMC
December 2018
1 Read

Prevalence of penile curvature: a population-based cross-sectional study in metropolitan and rural cities in Australia.

BJU Int 2018 Nov;122 Suppl 5:42-49

Department of Urology, Western Health, Melbourne, Vic., Australia.

Objective: To evaluate the prevalence of penile curvature and health-seeking behaviour in Australian men.

Patients And Methods: A population-based, cross-sectional anonymous web-based survey was designed, and men aged between 35 and 75 years in major and rural metropolitan cities across Australia were invited to participate. Respondents were screened for self-reported symptoms of penile curvature and their impact on various psychosexual domains. Read More

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http://doi.wiley.com/10.1111/bju.14605
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http://dx.doi.org/10.1111/bju.14605DOI Listing
November 2018
1 Read
3.533 Impact Factor

Superficial radiation therapy in peyronie's disease: An effective and well-tolerated therapy.

Adv Radiat Oncol 2018 Oct-Dec;3(4):548-551. Epub 2018 Aug 7.

Klinik und Poliklinik für Dermatologie und Allergologie am Biederstein, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.

Purpose: This study aimed to assess the safety, efficacy, and patient satisfaction of superficial radiation therapy in the treatment of Peyronie's disease (PD) in a retrospective analysis.

Methods And Materials: We performed a retrospective analysis of 83 patients who underwent radiation therapy between 1999 and 2008 with 8 fractions of 4 Gy over a period of 6 months. With a mean follow-up time of 52 months, patients responded to a comprehensive questionnaire that covered patient characteristics, disease duration before radiation therapy, course of disease, treatment response, side effects, and patient satisfaction. Read More

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http://dx.doi.org/10.1016/j.adro.2018.07.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6200896PMC
August 2018
4 Reads

Primary Treatment of Peyronie's Disease: A 55-yr-old Male with 45° Dorsal Penile Curvature and Good Erectile Function.

Authors:
Ranjith Ramasamy

Eur Urol Focus 2018 04 4;4(3):301. Epub 2018 Jul 4.

Department of Urology, University of Miami Miller School of Medicine, Miami, FL, USA. Electronic address:

Peyronie's disease is an abnormal curvature of the penis that affects sexual intercourse. The treatment options include injection therapy into the scar or surgical correction of the curvature using plication or grafting. Read More

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http://dx.doi.org/10.1016/j.euf.2018.06.017DOI Listing

Penile traction therapy with the new device 'Penimaster PRO' is effective and safe in the stable phase of Peyronie's disease: a controlled multicentre study.

BJU Int 2019 Apr 22;123(4):694-702. Epub 2018 Nov 22.

Rush University Medical Center, Chicago, IL, USA.

Objectives: To evaluate the efficacy and safety of a new penile traction device (PTD), 'Penimaster PRO', in a group of patients with stable Peyronie's disease (PD) compared with a non-intervention group in a multicentre study.

Material And Methods: A total of 93 patients with chronic stable PD (without erectile dysfunction, with no significant pain, and with a unidirectional curvature of at least 45° being stable for > 3 months) were recruited and followed for a 12-week period. Of these patients, 47 were randomly assigned to the Penimaster PRO group (PG) and 46 to the non-intervention group (NIG). Read More

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http://dx.doi.org/10.1111/bju.14602DOI Listing
April 2019
17 Reads

Long-term outcome after grafting with small intestinal submucosa and collagen fleece in patients with Peyronie´s disease: a matched pair analysis.

Int J Impot Res 2018 Oct 22. Epub 2018 Oct 22.

Department of Urology and Pediatric Urology, Julius-Maximilians-University of Würzburg, Würzburg, Germany.

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http://dx.doi.org/10.1038/s41443-018-0082-yDOI Listing
October 2018
1 Read

Antifibrotic Synergy Between Phosphodiesterase Type 5 Inhibitors and Selective Oestrogen Receptor Modulators in Peyronie's Disease Models.

Eur Urol 2019 02 19;75(2):329-340. Epub 2018 Oct 19.

Anglia Ruskin University, Chelmsford, UK. Electronic address:

Background: Peyronie's disease (PD) is a fibrotic disorder of the penile tunica albuginea, characterised by the formation of a localised fibrous plaque that can lead to deformity and erectile dysfunction. Nonsurgical therapeutic options for PD are limited in efficacy and safety. Myofibroblasts are key cells in the pathogenesis of PD, and inhibition of myofibroblast transformation has been suggested as a therapeutic option. Read More

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http://dx.doi.org/10.1016/j.eururo.2018.10.014DOI Listing
February 2019
16 Reads

Clinical Consultation Guide on Imaging in Male Infertility and Sexual dysfunction.

Eur Urol Focus 2018 04 14;4(3):338-347. Epub 2018 Oct 14.

Division of Male Reproductive Surgery and Men's Health, Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. Electronic address:

Imaging can benefit clinicians in evaluating men with infertility or sexual dysfunction by giving an overview of a patient's overall clinical condition before undertaking an invasive procedure. An understanding of the limitations and advantages of image modalities used in clinical practice will ensure that clinicians can optimize patient care with imaging when necessary. PATIENT SUMMARY: The objective of this article was to review the current literature on imaging modalities used for the diagnosis and management of male infertility and sexual dysfunction. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S24054569183029
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http://dx.doi.org/10.1016/j.euf.2018.09.018DOI Listing
April 2018
3 Reads

New Developments in Surgical Treatment for Penile Size Preservation in Peyronie's Disease.

Sex Med Rev 2019 01 6;7(1):156-166. Epub 2018 Oct 6.

Division of Urology, Department of Surgery, University of Texas Health Science Center, McGovern Medical School at Houston, Houston, TX, USA; University of Texas MD Anderson Cancer Center, Houston, TX, USA. Electronic address:

Introduction: Peyronie's disease (PD) is associated with penile length loss due to atrophy that occurs as a result of fibrous inelastic scarring. Studies have shown diminished penile length and girth, as well as the inability to participate in sexual activity, can lead to decreased quality of life, emotional challenges, and sexual dissatisfaction in a large percentage of men.

Aim: To provide a summary of the new developments in the surgical techniques available for the PD patient, with a focus on procedures that provide penile size restoration. Read More

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http://dx.doi.org/10.1016/j.sxmr.2018.07.001DOI Listing
January 2019

Advances in stem cell therapy for erectile dysfunction.

Expert Opin Biol Ther 2018 11 21;18(11):1137-1150. Epub 2018 Oct 21.

a Department of Urology , Tulane University Health Sciences Center , New Orleans , LA , USA.

Introduction: Stem cell (SC) application is a promising area of research in regenerative medicine, with the potential to treat, prevent, and cure disease. In recent years, the number of studies focusing on SCs for the treatment of erectile dysfunction (ED) and other sexual dysfunctions has increased significantly. Areas covered: This review includes critical ED targets and preclinical studies, including the use of SCs and animal models in diabetes, aging, cavernous nerve injury, and Peyronie's disease. Read More

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https://www.tandfonline.com/doi/full/10.1080/14712598.2018.1
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http://dx.doi.org/10.1080/14712598.2018.1534955DOI Listing
November 2018
2 Reads

The comparison of an acellular matrix graft with an autologous venous graft in the surgical treatment of Peyronie's disease.

Andrologia 2019 Feb 9;51(1):e13168. Epub 2018 Oct 9.

Department of Urology, Ankara Ataturk Education and Research Hospital, Ankara, Turkey.

The aim of this study was to evaluate acellular porcine pericardium (APP) and compared the results with those obtained from venous grafts in the surgical management of Peyronie's disease (PD). An APP (Group 1) and an autologous saphenous vein graft (Group 2) were used in 27 and 26 patients, respectively for Peyronie's correction. The patients' age, body mass index (BMI), operation time, duration of follow-up, preoperative and postoperative IIEF-5 scores, plaque size and loss of sensation were evaluated in both groups. Read More

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http://dx.doi.org/10.1111/and.13168DOI Listing
February 2019
3 Reads

Intratunical Injection of Stromal vascular fraction prevents Fibrosis in a Rat Model of Peyronie's Disease.

BJU Int 2018 Sep 29. Epub 2018 Sep 29.

Laboratory for Experimental Urology, Organ systems, Department of Development and Regeneration, University of Leuven, Leuven, Belgium.

Objective: Previous studies have shown that the injection of adipose tissue-derived stem cells (ADSCs) into the tunica albuginea (TA) during the active phase of the Peyronie's disease (PD) prevents the development of fibrosis and elastosis in the TA and corpus cavernosum The aim of this study was to investigate whether local injection of autologous adipose stromal vascular fraction (SVF) can prevent the development of fibrosis and elastosis in the TA using a rat model of acute phase of the Peyronie's disease (PD) METHODS: A total of 24 male 12-wk-old Sprague-Dawley rats were divided in three equal groups: sham, PD without treatment (TGFB) and PD treated with SVF (SVF) 1 day after disease induction. Sham rats underwent 2 injections of vehicle into the TA one day apart. TGFB rats underwent TGF- β1 injection and injection of vehicle one day later. Read More

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http://dx.doi.org/10.1111/bju.14570DOI Listing
September 2018
10 Reads

Clinical Efficacy of Injection and Mechanical Therapy for Peyronie's Disease: A Systematic Review of the Literature.

Eur Urol 2018 12 17;74(6):767-781. Epub 2018 Sep 17.

Department of Urology, University Hospitals Leuven, Leuven, Belgium.

Context: Conservative therapies for Peyronie's disease (PD) aim to treat early-stage disease by improving clinical outcomes such as penile curvature, penile length erectile dysfunction, and pain.

Objective: To summarise the available evidence regarding injection and mechanical therapies for PD treatment.

Evidence Acquisition: An extensive search of Medline, Embase, and Scopus databases retrieved English-language articles up to 15 May 2018. Read More

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http://dx.doi.org/10.1016/j.eururo.2018.07.005DOI Listing
December 2018
3 Reads

Plication for Severe Peyronie's Deformities Has Similar Long-Term Outcomes to Milder Cases.

J Sex Med 2018 Oct 15;15(10):1498-1505. Epub 2018 Sep 15.

Department of Urology, University of Texas Southwestern Medical Center, Dallas, TX, USA. Electronic address:

Introduction: Penile plication (PP) for Peyronie's disease (PD) is an established treatment option for mild to moderate curvature, but scant data exist regarding its utility in severe deformities.

Aim: To evaluate long-term outcomes among men undergoing PP for PD, comparing severe to mild/moderate penile deformities.

Methods: We performed a retrospective review of patients who underwent PP for PD between 2009 and 2017. Read More

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http://dx.doi.org/10.1016/j.jsxm.2018.08.006DOI Listing
October 2018
9 Reads

Xiaflex for Treatment of Peyronie's Disease.

Eur Urol Focus 2018 04 10;4(3):302-303. Epub 2018 Sep 10.

Department of Urology, Hackensack University Medical Center, Hackensack, NJ, USA; Divsion of Urology, Rutgers New Jersey Medical School, Newark, NJ, USA.

Xiaflex or collagenase Clostridium histolyticum intralesional injections are safe and effective as first-line treatment for Peyronie's disease. Read More

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http://dx.doi.org/10.1016/j.euf.2018.08.021DOI Listing
April 2018
24 Reads

Surgical Management of Peyronie's Disease.

Eur Urol Focus 2018 04 8;4(3):304-306. Epub 2018 Sep 8.

Department of Urology, University of Miami, Miami, FL, USA. Electronic address:

When choosing a management strategy for a patient with Peyronie's disease (PD), it is critical to consider the phase of the disease, penile plaque characteristics, degree of curvature, associated deformities, stretched penile length, and baseline erectile function. Equally important is an understanding of the patient's goals and expectations. Treatment cost and duration may also be vital considerations for the patient. Read More

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http://dx.doi.org/10.1016/j.euf.2018.08.026DOI Listing
April 2018
2 Reads

Penile Sensory Changes After Plaque Incision and Grafting Surgery for Peyronie's Disease.

J Sex Med 2018 Oct 6;15(10):1491-1497. Epub 2018 Sep 6.

Male Sexual and Reproductive Medicine Program, Urology Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY, USA. Electronic address:

Introduction: Plaque incision and grafting (PIG) for Peyronie's disease (PD) is not devoid of complications such as erectile dysfunction and penile sensory changes.

Aim: To define the rate and chronology of penile sensation loss after PIG surgery and to define predictors of such.

Methods: The study population consisted of patients with PD-associated penile curvature who underwent PIG surgery with at least 6 months of follow-up. Read More

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http://dx.doi.org/10.1016/j.jsxm.2018.07.020DOI Listing
October 2018
11 Reads

Intralesional and Mechanical Therapies for Peyronie's Disease: A Road Anything but Straight.

Eur Urol 2018 12 31;74(6):782-783. Epub 2018 Aug 31.

Department of Urology, Herlev and Gentofte Hospital, Herlev, Denmark.

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http://dx.doi.org/10.1016/j.eururo.2018.08.017DOI Listing
December 2018

[Low-intensity extracorporeal shockwave therapy for Peyronie's disease: A preliminary study of 32 cases].

Zhonghua Nan Ke Xue 2018 Apr;24(4):340-344

Department of Andrology, Henan Provincial People's Hospital, Zhengzhou, Henan 450000, China.

Objective: To investigate the clinical effect of low-intensity extracorporeal shockwave therapy (LI-ESWT) on Peyronie's disease.

Methods: From October 2016 to December 2017, we treated 32 cases of Peyronie's disease by LI-ESWT, with the therapeutic index of 0.09 mJ/mm2 and a pulse frequency of 120 beats/min. Read More

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April 2018
13 Reads

[Plaque excision plus autologous perididymal patch grafting for Peyronie's disease].

Zhonghua Nan Ke Xue 2018 Janurary;24(1):55-58

Department of Urology, Xuzhou Hospital Affiliated to Southeast University School of Medicine, Xuzhou, Jiangsu 221009, China.

Objective: To investigate the clinical effect of plaque excision plus autologous perididymal patch grafting in the treatment of Peyronie's disease.

Methods: This study included 10 patients with Peyronie's disease received in our Department of Urology between January 2013 and December 2015, who had failed to respond to over 12 months of expectant drug therapy and remained stable for more than 6 months, none able to perform sexual intercourse due to penile curvature (>60°). All the patients underwent plaque excision plus autologous perididymal patch grafting. Read More

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November 2018
4 Reads

Penile lengthening with porcine small intestinal submucosa grafting in Peyronie's disease treatment: long-term surgical outcomes, patients' satisfaction and dissatisfaction predictors.

Andrology 2018 Nov 3;6(6):909-915. Epub 2018 Aug 3.

Nuno Tomada Urologia e Cirurgia Reconstrutiva, Porto, Portugal.

Background: Peyronie's Disease (PD) is an acquired connective tissue disorder that often leads to penile curvature (PC) and sexual dysfunction. Penile lengthening procedures (PLP) with four-layered porcine small intestinal submucosa graft (Surgisis ES; Cook) have been widely used in patients with severe PC when erectile function is preserved. However, complications such as erectile dysfunction (ED) may limit treatment satisfaction. Read More

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http://dx.doi.org/10.1111/andr.12522DOI Listing
November 2018
10 Reads

Reproductive Urologists: Who Are They and Why Should We Care About Them?

Authors:
Ranjith Ramasamy

Eur Urol Focus 2018 04 23;4(3):295. Epub 2018 Jul 23.

Department of Urology, University of Miami, Miami, FL, USA. Electronic address:

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http://dx.doi.org/10.1016/j.euf.2018.07.008DOI Listing
April 2018
1 Read

Phase I and phase II clinical trials for the treatment of male sexual dysfunction-a systematic review of the literature.

Expert Opin Investig Drugs 2018 07 11;27(7):583-593. Epub 2018 Jul 11.

a Department of Urology , Università Vita-Salute San Raffaele , Milan , Italy.

Introduction: The prevalence of sexual dysfunctions has increased over the last decades; despite a number of available treatments for erectile dysfunction (ED), premature ejaculation (PE), and Peyronie's disease (PD), still several unmet therapeutic needs deserve to be fulfilled. The aim of this review is to detail on phase I and II clinical trials investigating novel medical treatments for ED, PE, and PD.

Areas Covered: We conducted a systematic review of the literature including both published and ongoing phase I and II registered trials focused on medical treatment of ED, PE, and PD during the last 5 years. Read More

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http://dx.doi.org/10.1080/13543784.2018.1495707DOI Listing
July 2018
9 Reads

The Use of Stromal Vascular Fraction in the Treatment of Male Sexual Dysfunction: A Review of Preclinical and Clinical Studies.

Sex Med Rev 2019 Apr 28;7(2):313-320. Epub 2018 Jun 28.

Tulane University School of Medicine, Department of Urology, New Orleans, LA, USA. Electronic address:

Introduction: Stem cell therapy using stromal vascular fraction (SVF) is a promising treatment modality. SVF is comprised of a mixture of adipose-derived stem cells, endothelial precursor cells, and immune modulatory cells that act synergistically to facilitate angiogenesis and epithelial cell differentiation. This makes SVF an attractive option for men's sexual disorders that require reconstitution of vasculature and endothelial lining, namely erectile dysfunction (ED) and Peyronie's disease (PD). Read More

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http://dx.doi.org/10.1016/j.sxmr.2018.04.001DOI Listing
April 2019
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Biomechanical Comparison of Inflatable Penile Implants: A Cadaveric Pilot Study.

J Sex Med 2018 Jul;15(7):1034-1040

Advanced Urology, Atlanta, GA, USA.

Background: Throughout the last decade there has been a growing interest in the biomechanical differences between inflatable penile prostheses (IPPs) and their significance with regard to the patient experience.

Aim: To present our findings assessing the biomechanical properties of IPPs with and without rear tip extenders (RTEs).

Methods: This is a biomechanical study of the 3 most commonly used IPPs (AMS CX, AMS LGX, and Coloplast Titan) as assessed by column compression, modified cantilever deflection, and 3-point bending methods. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S17436095183100
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http://dx.doi.org/10.1016/j.jsxm.2018.05.014DOI Listing
July 2018
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Plaque Calcification: An Important Predictor of Collagenase Clostridium Histolyticum Treatment Outcomes for Men With Peyronie's Disease.

Urology 2018 Sep 10;119:109-114. Epub 2018 Aug 10.

Department of Urology, Mayo Clinic, Rochester, MN.

Objective: To compare outcomes of men with or without calcified plaques undergoing collagenase Clostridium histolyticum (CCH) injections for Peyronie's disease (PD) and identify predictors of CCH success.

Materials And Methods: From March 2014 through January 2017, data were prospectively collected on 192 patients who underwent 1-4 cycles of CCH for the treatment of PD. Of these, 115 completed ≥2 CCH cycles and had data on curvature assessment. Read More

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http://dx.doi.org/10.1016/j.urology.2018.06.003DOI Listing
September 2018
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Reduction in Peyronie's-like plaque size using a vacuum erection device in a rat model of Peyronie's disease via the TGF-β/SMAD signalling pathway.

Andrologia 2018 Sep 28;50(7):e13051. Epub 2018 May 28.

Andrology Laboratory, West China Hospital, Sichuan University, Chengdu, China.

Peyronie's disease (PD) is a fibrotic disorder of the tunica albuginea (TA). This study aimed to determine the therapeutic effects of a vacuum erection device (VED) in an animal model of PD and explore the possible mechanisms. Twenty-seven male Sprague-Dawley rats were used. Read More

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http://dx.doi.org/10.1111/and.13051DOI Listing
September 2018
6 Reads