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    Changes in the Effects of Peyronie's Disease After Treatment With Collagenase Clostridium histolyticum: Male Patients and Their Female Partners.
    Sex Med 2017 Apr 5. Epub 2017 Apr 5.
    Australian Centre for Sexual Health, St Leonards, NSW, Australia.
    Introduction: Collagenase Clostridium histolyticum (CCH) intralesional injection was efficacious for the management of Peyronie's disease (PD) in the double-blinded, randomized, placebo-controlled Investigation for Maximal Peyronie's Reduction Efficacy and Safety Studies I and II (IMPRESS I and II). Little is known about the consequences of PD or treatment on the sexual partners of affected men.

    Aim: To assess the safety and efficacy of CCH treatment in men who received placebo in the IMPRESS I or II study and to evaluate the men's PD symptoms and partner bother as reported by female sexual partners. Read More

    Clinical Experience With Penile Traction Therapy Among Men Undergoing Collagenase Clostridium histolyticum for Peyronie Disease.
    Urology 2017 Mar 24. Epub 2017 Mar 24.
    Department of Urology, Mayo Clinic, Rochester, MN. Electronic address:
    Objective: To evaluate the outcomes in men undergoing collagenase Clostridium histolyticum (CCH) with concurrent penile traction therapy (PTT) for the treatment of Peyronie disease (PD).

    Materials And Methods: We identified patients treated with CCH between March 2014 and July 2016. Patients were recommended to perform modeling and PTT between injection series. Read More

    Low-Intensity Extracorporeal Shockwave Therapy in Sexual Medicine: A Questionnaire-Based Assessment of Knowledge, Clinical Practice Patterns, and Attitudes in Sexual Medicine Practitioners.
    Sex Med 2017 Mar 4. Epub 2017 Mar 4.
    Department of Urology, Amstelland Hospital, Amstelveen, The Netherlands.
    Introduction: Low-intensity extracorporeal shockwave therapy (LI-ESWT) has emerged as a treatment option for male sexual dysfunction. However, results have been contradictory.

    Aim: To investigate the knowledge, practice patterns, and attitudes regarding LI-ESWT among experts in sexual medicine. Read More

    Sexual Rehabilitation After Treatment For Prostate Cancer-Part 2: Recommendations From the Fourth International Consultation for Sexual Medicine (ICSM 2015).
    J Sex Med 2017 Mar;14(3):297-315
    Scott Department of Urology, Baylor College of Medicine, Houston, TX, USA.
    Introduction: Sexual dysfunction is common in patients after radical prostatectomy (RP) for prostate cancer.

    Aim: To provide the International Consultation for Sexual Medicine (ICSM) 2015 recommendations concerning management strategies for post-RP erectile function impairment and to analyze post-RP sexual dysfunction other than erectile dysfunction.

    Methods: A literature search was performed using Google and PubMed database for English-language original and review articles published up to August 2016. Read More

    Contemporary Review of Grafting Techniques for the Surgical Treatment of Peyronie's Disease.
    Sex Med Rev 2017 Feb 28. Epub 2017 Feb 28.
    Department of Urology, University of California-Irvine, Irvine, CA, USA.
    Introduction: Peyronie's disease (PD) is a benign fibrotic disorder of the tunica albuginea of the penis, which can cause penile pain, curvature, shortening, erectile dysfunction, and psychological distress. Surgery is indicated when penile curvature prevents satisfactory sexual intercourse. Plaque incision or excision with grafting has been suggested as an option in patients with a penile curvature greater than 60°, a shortened penis, and/or an hourglass or complex deformity. Read More

    Survey of patient and partner satisfaction following collagenase Clostridium histolyticum treatment for Peyronie's disease.
    Andrology 2017 Mar 10;5(2):274-277. Epub 2017 Feb 10.
    Department of Urology, Tulane University School of Medicine, New Orleans, LA, USA.
    Intralesional injection of collagenase Clostridium histolyticum (CCH) is a minimally invasive, Food and Drug Administration-approved, effective treatment for Peyronie's disease (PD). To assess the satisfaction of patients and their female sexual partners (FSP) following CCH therapy for PD, we conducted a retrospective review of the records of all patients treated with CCH for PD between 04/2014 and 03/2016. Collected variables included demographics, pre- and post-treatment sexual function, penile curvature, penile vascular findings, and treatment outcomes. Read More

    Role of extracorporeal shock wave therapy in management of Peyronie's disease: A preliminary report.
    Urol Ann 2016 Oct-Dec;8(4):409-417
    Department of Urology and Genito-Urinary Surgery, Ruby Hall Clinic, Pune, Maharashtra, India.
    Introduction: Peyronie's Disease (PD) is a disease causing psycho social trauma to the patient. Multiple treatment options are available with variable results. Extra Corporeal Shock Wave Therapy (ESWT) is a new insight into the non invasive modality of management. Read More

    Stem Cells in Male Sexual Dysfunction: Are We Getting Somewhere?
    Sex Med Rev 2017 Apr 29;5(2):222-235. Epub 2016 Dec 29.
    Laboratory of Experimental Urology, Department of Development and Regeneration, KU Leuven, Leuven, Belgium. Electronic address:
    Introduction: Stem cells for sexual disorders are steadily being introduced into clinical trials. Two conditions of importance are the main target for this line of treatment, especially when regarding the wide array of translational and basic science highlighting the potential advantages of regenerative therapy: erectile dysfunction (ED) and more recently Peyronie disease (PD). Cellular therapy offers a treatment modality that might reverse disease progression. Read More

    Nonsurgical treatment options in Peyronie's Disease: 2016 update.
    Turk J Urol 2016 Dec;42(4):217-223
    Department of Urology, Hamad General Hospital, Doha, Qatar.
    Peyronie's disease (PD) is an inflammatory condition of penile tunica albuginea which commonly ends with penile curvature and difficulty in vaginal penetration. Unfortunately, the pathophysiology of PD has not been completely understood. In this paper, we will review what is known about the pathophysiology of PD and the nonsurgical medical treatment options that have been trialed as a result. Read More

    Association Between Infertility and Sexual Dysfunction in Men and Women.
    Sex Med Rev 2016 Oct 4;4(4):353-365. Epub 2016 Jun 4.
    Department of Urology, University of Miami-Miller School of Medicine, Miami, FL, USA. Electronic address:
    Introduction: The relation between infertility and sexual dysfunction can be reciprocal. Causes of sexual dysfunction that affect fertility include erectile dysfunction, Peyronie's disease (abnormal penile curvature), low libido, ejaculatory disorders in men, and genito-pelvic pain/penetration disorder (GPPPD) and low sexual desire in women.

    Aim: To review the association between infertility and sexual dysfunction and discuss current management strategies to address sexual disorders in couples with infertility. Read More

    The Genetic Basis of Peyronie Disease: A Review.
    Sex Med Rev 2016 Jan 8;4(1):85-94. Epub 2016 Jan 8.
    Center for Reproductive Medicine, Baylor College of Medicine, Houston, TX, USA; Scott Department of Urology, Baylor College of Medicine, Houston, TX, USA. Electronic address:
    Introduction: Peyronie disease (PD) is a progressive fibrotic disorder of the penile tunica albuginea that results in fibrotic penile plaques and can lead to penile deformity. Characterized by aberrant fibrosis resulting in part from the persistence of myofibroblasts and altered gene expression, the molecular factors underpinning PD and other related fibrotic diatheses are just being elucidated. A genetic link to PD was first identified three decades ago using pedigree analyses. Read More

    Patient-reported long-term sexual outcomes following plication surgery for penile curvature: A retrospective 58-patient study.
    Prog Urol 2017 Jan 18;27(1):10-16. Epub 2016 Nov 18.
    Département d'urologie, centre hosptalier Lyon Sud, chemin du Grand-Revoyet, 69495 Pierre-Benite cedex, France. Electronic address:
    Objective: To evaluate long-term sexual function results following plication surgery for the correction of penile curvature using patient questionnaires.

    Methods: We performed a single-center, retrospective study in a cohort of patients with Peyronie's disease or congenital penile curvature. All patients who underwent plication surgery on the convex aspect using the Nesbit, Yachia or diamond-shaped techniques were included. Read More

    Small Intestinal Submucosa Grafting for Peyronie Disease: Outcomes and Patient Satisfaction.
    Urology 2017 Feb 4;100:117-124. Epub 2016 Nov 4.
    Department of Renal, Urological and Infectious Diseases, Centro Hospitalar de São João, Porto, Portugal; Faculty of Medicine, University of Porto, Porto, Portugal.
    Objective: To evaluate surgical outcomes and complications and assess overall patient satisfaction after small intestinal submucosa (SIS) grafting for Peyronie disease.

    Methods: Twenty-eight patients were treated with tunical incision and grafting with SIS. Mean age of the patients was 58 (range: 43-71) years. Read More

    Impact of Number of Cycles of Collagenase Clostridium Histolyticum on Outcomes in Patients With Peyronie's Disease.
    Urology 2017 Feb 2;100:125-130. Epub 2016 Nov 2.
    Department of Urology, Tulane University School of Medicine, New Orleans, LA. Electronic address:
    Objective: To analyze the impact of the number of cycles of collagenase Clostridium histolyticum (CCH) intralesional injection therapy on outcomes to further characterize CCH therapy.

    Methods: We conducted a retrospective review of the records of all patients treated with CCH for Peyronie disease between April 2014 and March 2016. Collected variables included demographics, pre- and posttreatment sexual function, penile curvature, penile vascular findings, and treatment outcomes. Read More

    Collagenase Clostridium Histolyticum for the Treatment of Peyronie's Disease: A 'Real World' Clinical Perspective.
    Drugs 2016 Oct;76(16):1523-1528
    Department of Urology, Tulane University School of Medicine, New Orleans, LA, USA.
    The introduction of collagenase Clostridium histolyticum (CCH) as a treatment option for Peyronie's disease (PD), defined as the abnormal formation of collagen on the tunica albuginea of the penis, has provided patients with a promising new conservative therapy. Studies have shown that CCH improves curvature by an average of 17°, and although patient and sexual partner satisfaction is high, the improvement has arguable clinical implications. Similarly, the efficacy and cost of CCH contrasts strongly with more invasive surgical management, and is further limited by rare, but serious, complications and several contraindications. Read More

    The clinical spectrum of syphilitic balanitis of Follmann: report of five cases and a review of the literature.
    J Eur Acad Dermatol Venereol 2016 Oct 16;30(10):1810-1813. Epub 2016 Jul 16.
    Outpatient Clinic of Dermato-Venereology, Triemli Hospital, Zürich, Switzerland.
    Background: Eugène Follmann first described syphilitic balanitis as a manifestation of primary syphilis in 1948 and since then it has been known as syphilitic balanitis of Follmann (SBF). So far, SBF has rarely been described in literature.

    Objectives: We are reporting five additional cases of SBF considering the broad differential diagnosis of balanitis. Read More

    A prospective, randomized, single - blind study comparing intraplaque injection of thiocolchicine and verapamil in Peyronie's Disease: a pilot study.
    Int Braz J Urol 2016 Sep-Oct;42(5):1005-1009
    Departamento de Urologia, Hospital Ipiranga, São Paulo, Brasil.
    Objectives: To compare the response to tiocolchicine and verapamil injection in the plaque of patients with Peyronie's disease.

    Materials And Methods: Prospective, single-blind, randomized study, selecting patients who have presented Peyronie's disease for less than 18 months. Thiocolchicine 4mg or verapamil 5mg were given in 7 injections (once a week). Read More

    --- ---Recent advances in managing Peyronie's disease.
    F1000Res 2016 26;5. Epub 2016 Sep 26.
    St James Hospital, Leeds, LS9 7TF, UK.
    Peyronie's disease remains an under-reported and debilitating problem which can result in significant physical and psychological symptoms for some men. The classic symptom complex includes penile curvature, penile plaque, and penile pain. Men can also present with erectile dysfunction, penile instability, and penile shortening, alongside feelings of low mood/libido, dysmorphobia, and low self-esteem. Read More

    Nonsurgical Interventions for Peyronie's Disease: Update as of 2016.
    World J Mens Health 2016 Aug 23;34(2):65-72. Epub 2016 Aug 23.
    The James Buchanan Brady Urological Institute and Department of Urology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
    Peyronie's disease (PD) is a debilitating condition of the penis that leads to significant pain, erectile dysfunction, and emotional distress in men. PD is likely underreported due to lack of knowledge of the disease and the absence of well-established available treatments. Surgical treatment can lead to sustained improvements, but is often associated with penile shortening and places the patient at risk for perioperative morbidity. Read More

    Review of Management Options for Patients With Atypical Peyronie's Disease.
    Sex Med Rev 2017 Apr 17;5(2):211-221. Epub 2016 Aug 17.
    Department of Urology, Tulane University School of Medicine, New Orleans, LA, USA. Electronic address:
    Introduction: Peyronie's disease (PD) is a wound-healing disorder of the tunica albuginea often associated with penile deformity. Less commonly, patients with PD might display atypical presentations such as ventral curvature, hourglass deformity, significantly shortened penis, and/or multiplanar curvature.

    Aim: To review the available literature on the prevalence of and management options for atypical PD. Read More

    Satisfaction of patients with Peyronie's disease after plaque surgery and bovine pericardium graft.
    Actas Urol Esp 2017 Mar 26;41(2):103-108. Epub 2016 Jul 26.
    Departamento de Urología, Sección Andrología, Hospital Italiano de Buenos Aires, Ciudad de Buenos Aires, Argentina.
    Introduction: Plaque and bovine pericardium graft surgery is a useful tool for treating Peyronie's disease.

    Objective: To determine patient satisfaction following this operation.

    Materials And Methods: This was a retrospective, observational and descriptive study. Read More

    Peyronie's Disease: Intralesional Therapy and Surgical Intervention.
    Curr Urol Rep 2016 Sep;17(9):60
    Department of Urology, Emory University School of Medicine, 1365 Clifton Road, NE, Building B, Suite 1400, Atlanta, GA, 30322, USA.
    Peyronie's disease is a collagen wound healing disorder of the penis that negatively affects the quality of life of afflicted men. According to the 2015 AUA Consensus Guidelines on Peyronie's Disease, minimally invasive intralesional therapies and surgical intervention form the basis of contemporary therapy for this disorder. These therapeutic options, along with selected portions of the guidelines, are explored in this review. Read More

    [Animal models of Peyronie's disease: An update].
    Zhonghua Nan Ke Xue 2016 May;22(5):446-9
    Peyronie's disease is characterized by local fibrosis of the tunica albuginea and relatively rare clinically. Few relevant basic researches could be retrieved, which might be attributed to the absence of a robust animal model of the disease as well as to its rareness. At present, some animal models available for Peyronie's disease have their own merits and demerits. Read More

    Malignant priapism due to penile metastases: Case series and literature review.
    Arch Ital Urol Androl 2016 Jul 4;88(2):150-2. Epub 2016 Jul 4.
    St Peter's Andrology and the Insitute of Urology, University College London Hospital, London.
    Malignant priapism secondary to penile metastases is a rare condition. This term was originally used by Peacock in 1938 to describe a condition of painful induration and erection of the penis due to metastatic infiltration by a neoplasm. In the current literature there are 512 case reports. Read More

    Buccal mucosa is a promising graft in Peyronie's disease surgery. Our experience and a brief literature review on autologous grafting materials.
    Arch Ital Urol Androl 2016 Jul 4;88(2):115-21. Epub 2016 Jul 4.
    Urologic Unit, Surgical Dpt, ASUR Marche Area Vasta 3, Macerata Civic Hospital.
    Aim: Peyronie's Disease (PD) is an under reported acquired benign condition that, at the moment, is not curable with medical therapy. Surgery represent the gold standard of treatment. Surgical approaches are several and they consist in "plication techniques" or plaque incision/excision with grafting of resulting albuginea defect. Read More

    Peyronie's disease: a literature review on epidemiology, genetics, pathophysiology, diagnosis and work-up.
    Transl Androl Urol 2016 Jun;5(3):280-9
    1 Department of Urology, King Saud Medical City, Riyadh, Saudi Arabia ; 2 Department of Urology, King Faisal Specialist Hospital and Research Center, Riyadh-1211, Saudi Arabia.
    Peyronie's disease (PD), a fibromatous disorder of the tunica albuginea of the penile corpus cavernosum, named after the French physician Francois de la Peyronie, is characterized by pain, plaque formation, penile curvature, and plaque calcification. The epidemiological data on PD is inconsistent, with recent reports stating a prevalence of up to 9%, and the condition affecting men of all ages, from teenagers to septuagenarians. We are just beginning to elucidate the role of genetics as a causative factor for PD. Read More

    Recent surgical advances in Peyronie's Disease.
    Acta Med Port 2016 Feb 29;29(2):131-8. Epub 2016 Feb 29.
    Serviço de Urologia. Hospital Santa Maria. Centro Hospitalar Lisboa Norte. Lisboa.
    Introduction: Peyronie's disease, a fibrotic disorder of the tunica albuginea of the penis, has been associated with penile shortening and some degree of erectile dysfunction. It affects patient's quality of life, leading to severe psychological, mental, and physical stress. Penile deformation hampers sexual life leading to depression, lack of sexual confidence, loss of sexual function and performance anxiety. Read More

    Evidence-Based Management Guidelines on Peyronie's Disease.
    J Sex Med 2016 Jun;13(6):905-23
    Department of Urology, Mayo Clinic, Jacksonville, FL, USA.
    Introduction: Despite recent advances in our knowledge and treatment strategies in Peyronie's Disease (PD), much remained unknown about this disease.

    Aim: To provide a clinical framework and key guideline statements to assist clinicians in an evidence-based management of PD.

    Methods: A systematic literature search was conducted to identify published literature relevant to PD. Read More

    Female Partners of Men With Peyronie's Disease Have Impaired Sexual Function, Satisfaction, and Mood, While Degree of Sexual Interference Is Associated With Worse Outcomes.
    J Sex Med 2016 Jul 18;13(7):1095-103. Epub 2016 May 18.
    Department of Urology, McGill University Health Center, Montreal, QC, Canada.
    Introduction: Peyronie's disease (PD) causes penile deformity and can result in sexual dysfunction and psychological distress. Currently, nothing is known about the psychosexual impact on the partners of men with PD. Research carried out on the partners of men with other chronic illnesses suggests that the partners of men with PD might have increased rates of sexual dysfunction and decreased sexual satisfaction. Read More

    The Efficacy of Medical Treatment of Peyronie's Disease: Potassium Para-Aminobenzoate Monotherapy vs. Combination Therapy with Tamoxifen, L-Carnitine, and Phosphodiesterase Type 5 Inhibitor.
    World J Mens Health 2016 Apr 30;34(1):40-6. Epub 2016 Apr 30.
    Department of Urology, Korea University College of Medicine, Seoul, Korea.
    Purpose: This study was designed to evaluate the efficacy of medical treatment of Peyronie's disease.

    Materials And Methods: A total of 109 patients with Peyronie's disease who had been treated from January 2011 to December 2014 were retrospectively reviewed in this study. Forty-four patients (Group 1) were treated with 12 mg of potassium para-aminobenzoate daily. Read More

    The Outcome of Multiple Slit on Plaque with Plication Technique for the Treatment of Peyronie's Disease.
    World J Mens Health 2016 Apr 30;34(1):20-7. Epub 2016 Apr 30.
    Department of Urology, Korea University College of Medicine, Seoul, Korea.
    Purpose: To evaluate the postoperative outcome of the multiple slit on plaque plication technique for the treatment of Peyronie's disease.

    Materials And Methods: We retrospectively evaluated 22 patients who underwent plaque incision with penile plication for the surgical treatment of Peyronie's disease, who had failed medical treatment between 2009 and 2014. Patients were grouped by preoperative degree of penile curvature into Group I: mild (n=5, 22. Read More

    Primary Mixed Glandular-endocrine Tumor of the Male Proximal Urethra: A Case Report.
    Urol Case Rep 2016 May 6;6:1-3. Epub 2016 Feb 6.
    FACERES, Brazil.
    Primary urethral carcinoma is much more common in women than in men due to its association with urethritis. A 65-year-old man presented with a 10-month history of penile induration, obstructive voiding symptoms and hematuria. Urethrocystoscopy showed a solitary mass in the proximal urethra and no bladder involvement. Read More

    Alternative Splicing of IGF1 Gene as a Potential Factor in the Pathogenesis of Peyronie's Disease.
    In Vivo 2016 May-Jun;30(3):251-6
    Department of Physiology, Medical School, National and Kapodistrian University of Athens, Goudi, Athens, Greece.
    Background/aim: Peyronie's disease (PD) is a fibrotic entity for which the pathogenetic mechanism remains unclear and if resulting in severe deformity, its treatment is only surgical. In this study we investigated the possible role of insulin-like growth factor 1 (IGF1) expression in the pathogenesis of PD.

    Materials And Methods: Tissue samples were obtained from plaques of 24 patients with PD. Read More

    Penile intracavernosal pillars: lessons from anatomy and potential implications for penile prosthesis placement.
    Int J Impot Res 2016 May 7;28(3):114-9. Epub 2016 Apr 7.
    Department of Urology, Columbia University Medical Center, New York, NY, USA.
    The objective of this study was to anatomically describe the relationship of penile intracavernosal pillars to penile surgery, specifically corporal dilation during penile prosthesis placement. Corpora cavernosa from four embalmed male cadavers were dissected and subjected to probe dilation. Corpora were cross-sectioned and examined for the gross presence and location of pillars and dilated spaces. Read More

    Results of SMSNA Survey Regarding Complications Following Intralesional Injection Therapy With Collagenase Clostridium Histolyticum for Peyronie's Disease.
    J Sex Med 2016 Apr 25;13(4):684-9. Epub 2016 Mar 25.
    Department of Urology, Tulane University School of Medicine, New Orleans, LA, USA. Electronic address:
    Introduction: Intralesional injection of collagenase clostridium histolyticum (CCH) for Peyronie's disease (PD) can result in serious adverse events such as hematoma formation and corporal rupture.

    Aim: To investigate the prevalence of complications from CCH and management trends among CCH prescribers.

    Methods: A survey was sent to all 693 members of the Sexual Medicine Society of North America (SMSNA) with valid email addresses. Read More

    Penile Prosthesis Surgery: Current Recommendations From the International Consultation on Sexual Medicine.
    J Sex Med 2016 Apr 25;13(4):489-518. Epub 2016 Mar 25.
    Department of Urology, UT Southwestern Medical Center, Dallas, TX, USA.
    Introduction: Penile prosthesis implantation has emerged as a definitive treatment to restore sexual function to the motivated man with erectile dysfunction. Substantial improvements in the design of inflatable devices have been made since they first became available more than four decades ago.

    Aim: To review the history of the penile prosthesis, the indications, preoperative evaluation, and patient and partner satisfaction. Read More

    Surgical treatment of Peyronie's disease with small intestinal submucosa graft patch.
    Int J Impot Res 2016 May 31;28(3):106-9. Epub 2016 Mar 31.
    Andrology Department, Fundació Puigvert, Universitat Autonoma de Barcelona, Barcelona, Spain.
    The objective of the study was to report our results using a porcine small intestinal submucosa graft (Surgisis ES, Cook Medical) for tunica albuginea substitution after plaque incision. We retrospectively evaluated patients surgically treated at our institution for Peyronie's disease (PD) by means of plaque incision and porcine small intestinal submucosa grafting (Surgisis) between 2009 and 2013. At the same time a literature review was conducted, searching for similar reports and results. Read More

    Intralesional Injection of Hyaluronic Acid in Patients Affected With Peyronie's Disease: Preliminary Results From a Prospective, Multicenter, Pilot Study.
    Sex Med 2016 Jun 13;4(2):e83-8. Epub 2016 Mar 13.
    Urology Department, University of Naples Federico II, Naples, Italy.
    Introduction: Hyaluronic acid has been shown to be efficacious in decreasing scar formation, inflammation, and oxidative stress.

    Aim: To assess the efficacy of intralesional injection of hyaluronic acid in patients affected by Peyronie's disease.

    Methods: In this prospective, single-arm, self-controlled, interventional, multicenter pilot study, 65 patients underwent a 10-week cycle of weekly intraplaque injections with hyaluronic acid (0. Read More

    Increased aquaporin 1 expression in the tunica albuginea of Peyronie's disease patients: an in vivo pilot study.
    Histol Histopathol 2016 Nov 14;31(11):1241-9. Epub 2016 Mar 14.
    Department of Experimental Medicine and Surgery, Tor Vergata University of Rome, Rome, Italy.
    Peyronie's disease (PD) is a localized disorder of the connective tissue of the tunica albuginea (TA) whose etiology has not been elucidated. Although several studies have implicated genetic susceptibility and/or mechanical trauma as triggering events for PD, the underlying molecular mechanisms remain largely unknown. Aquaporin 1 (AQP1) is a water channel protein potentially implicated in connective tissue resistance to mechanical stress, acting primarily by increasing tension within the collagen network. Read More

    The Genetic Basis of Peyronie's Disease: A Review.
    Sex Med Rev 2016 Jan;4(1):85-94
    Center for Reproductive Medicine, Baylor College of Medicine, Houston, TX 77030; Scott Department of Urology, Baylor College of Medicine, Houston, TX 77030.
    Introduction: Peyronie's disease (PD) is progressive fibrotic disorder of the penile tunica albuginea that results in fibrotic penile plaques and may lead to penile deformity. Characterized by aberrant fibrosis resulting in part from persistence of myofibroblasts as well as altered gene expression, the molecular factors underpinning Peyronie's disease and other related fibrotic diatheses are just being elucidated. A genetic link to PD was first identified using pedigree analyses three decades ago. Read More

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