2,187 results match your criteria Peyronie Disease


Treatment Related Outcomes for Patients with Atypical Peyronie's Disease using Xiaflex Injections.

Urology 2020 Jun 23. Epub 2020 Jun 23.

University of California Irvine, Irvine, California. Electronic address:

Objectives: To evaluate the efficacy and safety of collagenase Clostridium histolyticum (CCH) for the management of penile deformities in patients presenting with different categories of atypical Peyronie's disease (PD).

Methods: We conducted a retrospective review of charts of patients who presented to a men's health clinic with atypical PD between October 2016 and June 2019. We included patients in the stable phase of the disease, had completed a penile duplex Doppler ultrasound before any intervention, and proceeded with CCH treatment. Read More

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http://dx.doi.org/10.1016/j.urology.2020.05.076DOI Listing

The relationship between testosterone levels and Peyronie's disease.

Andrologia 2020 Jun 26:e13727. Epub 2020 Jun 26.

Department of Urology, Cemil Taşcıoglu City Hospital, Istanbul, Turkey.

Aetiologic and predisposing factors are still controversial about Peyronie's disease (PD). However, it is thought to be the result of connective tissue disorder or healing defect. Androgens are known to affect collagen metabolism and wound healing in the body. Read More

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http://dx.doi.org/10.1111/and.13727DOI Listing

Evaluating the Impact of Penile Girth Discrepancy on Patient Bother in Men With Peyronie's Disease: An Observational Study.

J Sex Med 2020 Jun 20. Epub 2020 Jun 20.

Department of Urology, Memorial Sloan Kettering Cancer Center, New York, NY, USA. Electronic address:

Background: Men with Peyronie's disease (PD) may experience penile narrowing. Little data on penile girth changes and their psychosocial impact exist.

Aim: To assess girth discrepancy in men with PD and its association with patient bother. Read More

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http://dx.doi.org/10.1016/j.jsxm.2020.05.003DOI Listing

A clinical pathway for the management of Peyronie's disease: integrating clinical guidelines from the International Society of Sexual Medicine, American Urological Association and European Urological Association.

BJU Int 2020 Jun 16. Epub 2020 Jun 16.

Urology South, Moorabbin, Vic., Australia.

Objective: To provide a clinical framework and key guideline statements to assist clinicians in the evidence-based management of Peyronie's disease (PD).

Methods: We conducted a review of the published literature relevant to PD management, with an emphasis on published clinical guidelines. References used in the text have been assessed according to their level of evidence, and guideline recommendations have been graded based on the Oxford Centre for Evidence-based Medicine Levels of Evidence. Read More

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http://dx.doi.org/10.1111/bju.15057DOI Listing
June 2020
3.533 Impact Factor

[Andrology and penile cancer. Recommendations during COVID-19 pandemia.]

Arch Esp Urol 2020 Jun;73(5):395-404

Servicio de Urología. Hospital Puerta de Hierro. Lyx Instituto de Urología. Universidad Francisco de Vitoria. Madrid. España.

Purpose: The COVID-19 pandemic which has affected Spain since the beginning of 2020 compels us to determine recomendations for the practice of Andrology in present times.

Materials And Methods: A web search is carried out in English and Spanish and a joint proposal is defined by experts in Andrology from different regions of Spain.

Results: Most diagnostic and therapeutic procedures in Andrology can be safey postponed during the COVID-19 pandemic. Read More

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Recent advances in managing Peyronie's disease.

F1000Res 2020 20;9. Epub 2020 May 20.

Department of Urology, Leeds Teaching Hospitals, Leeds, UK.

Treating men with Peyronie's disease remains a challenging problem facing clinicians working across urology and sexual medicine fields. Patients can often be left disappointed by current treatment paradigms, and an overall lack of suitable molecular targets has limited the options for novel, effective medical therapy. Managing men with Peyronie's disease often involves careful counselling alongside multifaceted and possible combination treatments to help improve symptoms whilst ameliorating potential side effects of therapy. Read More

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http://dx.doi.org/10.12688/f1000research.20557.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7255896PMC

Review of the Current Status of Low Intensity Extracorporeal Shockwave Therapy (Li-ESWT) in Erectile Dysfunction (ED), Peyronie's Disease (PD), and Sexual Rehabilitation After Radical Prostatectomy With Special Focus on Technical Aspects of the Different Marketed ESWT Devices Including Personal Experiences in 350 Patients.

Authors:
Hartmut Porst

Sex Med Rev 2020 Jun 1. Epub 2020 Jun 1.

European Institute for Sexual Health (EISH), Hamburg, Germany. Electronic address:

Introduction: Although the literature of the positive effects of penile low intensity extracorporeal shockwave therapy is meanwhile substantial, there are substantial differences regarding both the sources of energies and extracorporeal shockwave therapy (ESWT) devices.

Objectives: To provide an overview on the energy range and energy differences of the 6 currently marketed ESWT devices along with personal ESWT experiences in 350 patients.

Methods: This review includes all published preclinical and clinical penile ESWT studies with evaluation of the technical differences of the 6 ESWT devices and the personal experiences with these 6 devices in ED and PD. Read More

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http://dx.doi.org/10.1016/j.sxmr.2020.01.006DOI Listing

Peyronie Disease as an Example of Nononcological, Inflammatory Uptake of 18F-Fluorocholine in Patient With Prostate Cancer.

Clin Nucl Med 2020 Jul;45(7):575-576

Nuclear Medicine Department, Affidea Poznan.

F-fluorocholine PET/CT is commonly used for staging and assessing treatment response in prostate cancer patients. Growing clinical experience has shown that F-fluorocholine can actually accumulate in sites of inflammation. We report a rare case of a prostate cancer patient with incidentally detected Peyronie disease. Read More

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http://dx.doi.org/10.1097/RLU.0000000000003082DOI Listing

[Extracorporeal shock wave therapy for Peyronie's disease].

Prog Urol 2020 May 1. Epub 2020 May 1.

Sorbonne Université, GRC 5 Predictive Onco-Uro, AP-HP, Urologie, Pitie-Salpétrière, 75013 Paris, France. Electronic address:

Introduction: The efficiency of extracorporeal shock waves (SW) for Peyronie's disease (PD) is controversial.

Methods: A systematic review of the literature published between 2000 and 2019 was conducted using the PRISMA methodology. We used Medline data with the following. Read More

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http://dx.doi.org/10.1016/j.purol.2020.04.003DOI Listing

Efficacy of Collagenase Clostridium histolyticum (Xiapex) in Patients with the Acute Phase of Peyronie's Disease.

Clin Drug Investig 2020 Jun;40(6):583-588

Andrology Center, Villa Donatello Hospital, Florence, Italy.

BACKGROUND AND OBJECTIVE: Plaque formation ordinarily takes place in the acute phase of Peyronie's disease. There is no unanimous consent regarding the management of the acute phase of Peyronie's disease. The objective of this study was to evaluate the advantages of using a single intralesional injection of collagenase Clostridium histolyticum in patients with the active phase of Peyronie's disease and to assess its effect on disease progression by reducing penile curvature and ameliorating pain during sexual intercourse. Read More

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http://dx.doi.org/10.1007/s40261-020-00916-4DOI Listing

Complex Peyronie's disease cases: surgery with or without penile prosthesis placement.

Actas Urol Esp 2020 Apr 14. Epub 2020 Apr 14.

Lyx Instituto de Urología, Universidad Francisco de Victoria, Madrid, España; Servicio de Urología, Hospital Universitario Puerta de Hierro Majadahonda, Madrid, España. Electronic address:

Introduction And Objective: Surgery is the treatment of choice for patients with Peyronie's disease presenting difficulty in penetration or erectile dysfunction without adequate response to therapy. Several techniques have been described, and urologists must be aware of their possible complications and sequelae in order to offer the patient the best possible alternative.

Patients And Methods: Three complex cases of patients with Peyronie's disease are presented. Read More

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http://dx.doi.org/10.1016/j.acuro.2020.01.008DOI Listing

[Non-surgical management of Peyronie's disease: State of current knowledge].

Prog Urol 2020 May 9;30(6):353-364. Epub 2020 Apr 9.

Service d'urologie, centre hospitalier René-Dubos, Pontoise, France.

Background: Peyronie's disease is an inflammatory disorder of the penis, where scar tissue creates a plaque at the level of the albuginea, limits its extension, and leads to a bent and shorter penis during erections. There are no international standards for the evaluation and the treatment of the disease. The aim of this article is to review the current knowledge about the management of Peyronie's disease and to suggest an algorithm to help physicians evaluate and manage this condition. Read More

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http://dx.doi.org/10.1016/j.purol.2020.03.002DOI Listing

Enlargement of length and girth associated with implantation of penile prostheses.

Authors:
P H Egydio

Actas Urol Esp 2020 Apr 9. Epub 2020 Apr 9.

Egydio Medical Center, Sao Paulo, Brasil. Electronic address:

Introduction: Reduction in penile size is due to numerous conditions including Peyronie's disease, previous penile surgeries, diabetes, trauma, erectile dysfunction, pelvic surgery, and aging. Elasticity of the tunica albuginea is adversely affected by any of the above. Fibrosis then triggers progressive erectile dysfunction OBJECTIVES: When a penile prosthesis is indicated, it is important to determine whether the penis has already diminished in size prior to insertion of the implant. Read More

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http://dx.doi.org/10.1016/j.acuro.2019.10.015DOI Listing

Discussion: Prevalence of Peyronie and Ledderhose Diseases in a Series of 730 Patients with Dupuytren Disease.

Plast Reconstr Surg 2020 04;145(4):985-986

Calgary, Alberta, Canada; and Ann Arbor, Mich. From the Section of Plastic Surgery, University of Calgary, Foothills Medical Centre; and the Section of Plastic Surgery, The University of Michigan Health System.

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http://dx.doi.org/10.1097/PRS.0000000000006643DOI Listing

Prevalence of Peyronie and Ledderhose Diseases in a Series of 730 Patients with Dupuytren Disease.

Plast Reconstr Surg 2020 04;145(4):978-984

Groningen, The Netherlands From the Departments of Urology and Plastic and Reconstructive Surgery, University of Groningen and University Medical Center Groningen.

Background: Dupuytren, Peyronie, and Ledderhose diseases are related fibroproliferative disorders characterized by abnormalities in the connective tissue of the palm of the hand, the tunica albuginea of the penis, and the sole of the foot, respectively. Concomitant prevalence rates of these diseases have only been described in a few small populations. This article aims to report on a large population and to raise awareness in surgeons treating Dupuytren disease for concurring related fibroproliferative disorders. Read More

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http://dx.doi.org/10.1097/PRS.0000000000006642DOI Listing

Advances in stem cell therapy for the treatment of Peyronie's disease.

Intractable Rare Dis Res 2020 Feb;9(1):10-13

Clinic of Dermatology, Dr. Brinkmann, Schult & Samimi-Fard, Gladbeck, Germany.

Peyronie's disease (PD) is a connective tissue disorder of the penis characterized by fibrosis and plaque formation within the tunica albuginea. PD is characterized by painful penile curvature that impairs sexual intercourse. Stem cell therapy is one of the recent non-invasive treatment options for patients with PD and it has promising results. Read More

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http://dx.doi.org/10.5582/irdr.2019.01130DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7062597PMC
February 2020

Review of Intralesional Collagenase Clostridium Histolyticum Injection Therapy and Related Combination Therapies in the Treatment of Peyronie's Disease (an Update).

Sex Med Rev 2020 Mar 18. Epub 2020 Mar 18.

Department of Urology, Tulane University School of Medicine, New Orleans, USA. Electronic address:

Introduction: Collagenase Clostridium histolyticum (CCH) is an injectable agent used to treat Peyronie's disease (PD) by enzymatically degrading the interstitial collagen in plaques. CCH has been administered via multiple treatment protocols, in combination therapies, to patients with varying curvatures and in both the acute and stable phases of this condition.

Objectives: To review the current literature and provide an update on CCH as an injectable therapy for PD, as a singular therapy or in conjunction with combination therapies, and its associated complications. Read More

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http://dx.doi.org/10.1016/j.sxmr.2020.01.005DOI Listing

Multicenter Experience Using Collagen Fleece for Plaque Incision With Grafting to Correct Residual Curvature at the Time of Inflatable Penile Prosthesis Placement in Patients With Peyronie's Disease.

J Sex Med 2020 Jun 18;17(6):1168-1174. Epub 2020 Mar 18.

Department of Urology, Mayo Clinic, Rochester, MN, USA. Electronic address:

Background: Adjuvant maneuvers are often necessary to correct residual curvature during inflatable penile prosthesis (IPP) placement in patients with Peyronie's disease (PD).

Aim: We present our multicenter experience using collagen fleece as graft material for plaque incision and grafting (PIG) during IPP placement in patients with moderate to severe PD.

Methods: We retrospectively reviewed 51 patients with IPP from 3 sites who underwent PIG with Tachosil (Baxter, IL) collagen fleece. Read More

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http://dx.doi.org/10.1016/j.jsxm.2020.02.019DOI Listing

[Peyronie's Disease: update in 2020].

Rev Med Suisse 2020 Mar;16(686):531-538

MHISC (Men's Health International Surgical Center), 3, route du Muids, 1272 Genolier.

Peyronie's disease (PD) is a relatively unknown cause of sexual dysfunction. Symptoms may include the appearance of an erectile deformity, pain in the penis and erectile dysfunction (ED). The etiology is most often unclear, and medical treatments are limited, although improvement is always possible. Read More

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Scrotal septum detachment during penile plication to compensate for loss of penile length compared with conventional surgical technique.

Investig Clin Urol 2020 Mar 18;61(2):224-230. Epub 2020 Feb 18.

Department of Urology, Korea University Guro Hospital, Seoul, Korea.

Purpose: To evaluate the efficacy and safety of penile elongation featuring simple scrotal septum detachment from the penile base to compensate for the loss of penile length during penile plication in patients with Peyronie's disease compared with conventional penile plication.

Materials And Methods: We conducted a retrospective analysis of 38 patients (24-75 years of age) with Peyronie's disease who underwent penile plication with or without our novel technique from January 2009 to May 2018. Penile elongation was achieved by release and detachment of the scrotal septum from the penile base to the level of the scrotal fat tissue. Read More

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http://dx.doi.org/10.4111/icu.2020.61.2.224DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7052414PMC

The Use of Penile Computed Tomography Cavernosogram in the Evaluation of Peyronie's Disease: A Pilot Study.

J Sex Med 2020 May 4;17(5):1041-1043. Epub 2020 Mar 4.

Department of Radiology, Lahey Hospital & Medical Center, Burlington, MA, USA.

Background: Clinical assessment of Peyronie disease (PD) is unreliable and difficult to reproduce.

Aim: To assess the utility of the computed tomography cavernosography (CTC) in evaluating the penile functional abnormalities of PD.

Methods: Men were placed in the Philips IQon Spectral CT scanner (Phillips, Cambridge, MA, USA) in the supine position. Read More

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http://dx.doi.org/10.1016/j.jsxm.2020.01.023DOI Listing

[Reconstructive possibilities for Peyronie's disease].

Authors:
Herbert Sperling

Urologe A 2020 Apr;59(4):426-431

Urologische Klinik, Kliniken Maria Hilf GmbH, Viersener Str. 450, 41063, Mönchengladbach, Deutschland.

The surgical treatment of Peyronie's disease involves a multistage procedure with increasing invasiveness. In addition to precise knowledge about the existing surgical treatment procedures, the indication and the informed consent process of the patient is extremely important. The dissatisfaction with the surgical results for many patients is due to false expectations and positivistic representations. Read More

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http://dx.doi.org/10.1007/s00120-020-01154-4DOI Listing

Characteristics of Men With Peyronie's Disease and Collagenase Clostridium Histolyticum Treatment Failure: Predictors of Surgical Intervention and Outcomes.

J Sex Med 2020 May 29;17(5):1005-1011. Epub 2020 Feb 29.

Division of Urology, Rush University Medical Center, Chicago, IL, USA.

Background: A subset of patients with Peyronie's disease (PD) treated with collagenase clostridium histolyticum (CCH) experience persistent bother and some require surgery.

Aim: We characterize patients experiencing persistent bother after CCH treatment and identify associations and predictors of surgical intervention/outcomes.

Methods: We retrospectively identified patients with PD from October 2014 to October 2019 and identified those presenting with persistent bother after CCH treatment by other urologists. Read More

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http://dx.doi.org/10.1016/j.jsxm.2020.02.002DOI Listing

[Plaque incision and Tachosil graft in Peyronie's Disease].

Prog Urol 2020 Feb 14;30(2):119-125. Epub 2020 Feb 14.

Hopital Privé Jean Mermoz, 55 avenue Jean Mermoz, 69008 Lyon, France.

Introduction: Surgery is a treatment for correction of penile curvature in Peyronie's disease. Partial plaque excision and grafting is recommended for severe and complex curvature.

Methods: Patients with stable penile curvature who underwent a partial plaque excision and grafting between January 2017 and April 2018 were retrospectively included. Read More

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http://dx.doi.org/10.1016/j.purol.2019.11.011DOI Listing
February 2020

Management of severe complications following penile surgery for erectile dysfunction and Peyronie disease: Three case reports.

Medicine (Baltimore) 2020 Feb;99(7):e18690

Division of Urology, Department of Emergency and Organ Transplantation, University of Bari, Bari.

Rationale: Erectile dysfunction (ED) and Peyronie's disease (PD) are conditions commonly observed in andrology. Despite the surgical refinement and the technical improvement in this field, even in expert hands, detrimental consequences have been reported and it can be related to patient's comorbidities or misconduct in the postoperative period. In this article we report anecdotal cases of severe complications following penile surgery for ED and PD in high volume centers, describe the strategies adopted to treat it and discuss the options that would have helped preventing these events. Read More

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http://dx.doi.org/10.1097/MD.0000000000018690DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7035019PMC
February 2020

Comparison of Intralesional Hyaluronic Acid Verapamil for the Treatment of Acute Phase Peyronie's Disease: A Prospective, Open-Label Non-Randomized Clinical Study.

World J Mens Health 2020 Jan 20. Epub 2020 Jan 20.

Department of Urology, Vittorio Emanuele II, University of Catania, Catania, Italy.

Purpose: To compare the efficacy and safety of intralesional hyaluronic acid (HA) as compared with verapamil injection in patients with Peyronie's disease (PD).

Materials And Methods: Between January 2015 and December 2018, men in PD acute phase were prospectively recruited. This open-label, prospective study included 2 different protocols. Read More

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http://dx.doi.org/10.5534/wjmh.190108DOI Listing
January 2020

Prevalence, Risk Factors, and Erectile Dysfunction Associated With Peyronie's Disease Among Men Seeking Urological Care.

Sex Med 2020 Jun 30;8(2):230-236. Epub 2020 Jan 30.

Department of Urology, Faculdade Medicina ABC, Santo André, Brazil.

Introduction: Peyronie's disease (PD) is a connective tissue disorder of the penis characterized by an abnormality in collagen structure of penile tunica albuginea.

Aim: We sought to investigate the prevalence, risk factors, and the relationship between erectile dysfunction (ED) and PD in male patients aged 30-80 years seeking urological care.

Methods: This is a cross-sectional study using data collected from October 2016 to October 2017 in an outpatient clinic associated with the Brazilian Public Health System. Read More

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http://dx.doi.org/10.1016/j.esxm.2019.11.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7261680PMC

Second cycle of intralesional Collagenase Clostridium histolyticum for Peyronie's disease using the modified shortened protocol: Results from a retrospective analysis.

Andrologia 2020 Apr 31;52(3):e13527. Epub 2020 Jan 31.

Urology Unit, Department of Neurosciences, Reproductive Sciences, and Odontostomatology, University of Naples "Federico II", Naples, Italy.

The purpose of this study was to evaluate the effectiveness and safety of the second cycle of Collagenase Clostridium histolyticum injections using the modified shortened protocol. We performed a retrospective analysis on patients who had already undergone the first cycle of injections using the modified shortened protocol and requested more injections to improve the remaining curvature. The International Index of Erectile Function, the Peyronie's Disease Questionnaire and the Global Assessment of Peyronie's Disease questionnaire were self-administered to all patients. Read More

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http://dx.doi.org/10.1111/and.13527DOI Listing

Surgical repair of residual curvature after penile implant.

Arch Esp Urol 2020 Jan;73(1):78-79

Servicio de Urología. Hospital del Henares. Coslada. Madrid. España.

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January 2020

Long-Term Safety and Curvature Deformity Characterization in Patients Previously Treated with Collagenase clostridium Histolyticum for Peyronie's Disease.

J Urol 2020 Jun 10;203(6):1191-1197. Epub 2020 Jan 10.

Urology Associates Medical Group, Burbank, California.

Purpose: We assessed the long-term safety and immunogenicity profile of collagenase clostridium histolyticum and characterized penile curvature deformity over time in patients previously treated for Peyronie's disease.

Materials And Methods: This phase 4 study included men who received collagenase clostridium histolyticum in either 12-month, double-blind, placebo controlled clinical trials (IMPRESS I/II), or one of two 9-month open label studies. Eligible patients received no additional collagenase clostridium histolyticum treatment and were followed once yearly for up to 5 years to assess Peyronie's disease clinical symptoms, patient reported outcomes and safety. Read More

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http://dx.doi.org/10.1097/JU.0000000000000743DOI Listing

Impact of the Advent of Collagenase Clostridium Histolyticum on the Surgical Management of Peyronie's Disease: A Population-Based Analysis.

Authors:
Jesse N Mills

J Sex Med 2020 01;17(1):168

David Geffen School of Medicine at UCLA, Los Angeles, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jsxm.2019.10.013DOI Listing
January 2020

Urological Evidence of Tick Bites in Children.

Pediatr Emerg Care 2019 Dec 20. Epub 2019 Dec 20.

Norton Children's Urology, Norton Healthcare, Louisville, KY.

Ticks pose a serious threat to individuals of all ages owing to numerous physical illnesses including chills, aches, and a rash. Tick-borne illnesses range from a mild fever that may be treated at home to a severe disease necessitating hospitalization. Children are at an increased risk of tick bites owing to to their exposure to tick-infested areas during the summer. Read More

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http://dx.doi.org/10.1097/PEC.0000000000001933DOI Listing
December 2019

Safety of Collagenase Clostridium histolyticum Injection Therapy for Peyronie Disease in Patients Continuing Antiplatelet or Anticoagulant Therapy.

J Sex Med 2020 02 20;17(2):353-356. Epub 2019 Dec 20.

Department of Urology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA. Electronic address:

Introduction: The initial clinical trials for intralesional collagenase Clostridium histolyticum (CCh) injection therapy for Peyronie disease (PD) excluded men on antiplatelet or anticoagulant medications except those on low-dose aspirin. Men with PD who take such medications present a challenging clinical scenario because of a lack of evidence regarding the safety of CCh while on these drugs.

Aim: To evaluate safety outcomes among patients continuing anticoagulant and antiplatelet therapy during ongoing intralesional CCh injection treatment for PD. Read More

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http://dx.doi.org/10.1016/j.jsxm.2019.11.002DOI Listing
February 2020

Dupuytren contracture as a sign of systemic disease.

Clin Dermatol 2019 Nov - Dec;37(6):675-678. Epub 2019 Jul 31.

The London Clinic, London, England.

Dupuytren contracture (DC) is predominantly an autosomal dominant disorder characterized by hypertrophy and contraction of the palmar fascia that results in tethered flexion of the affected digits. It has its highest prevalence in the North European population or in people of Viking descent, and its incidence is growing with age. DC shares a common inheritance mode, predisposing factors, comorbidities, pathophysiology, and evolution with Ledderhose disease, Garrod knuckle pads, and Peyronie disease. Read More

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http://dx.doi.org/10.1016/j.clindermatol.2019.07.027DOI Listing

Peyronie's disease in contemporary urological practice.

World J Urol 2020 02;38(2):251-252

Division of Andrology, Department of Urology, David Geffen School of Medicine, University of California, Los Angeles, USA.

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http://dx.doi.org/10.1007/s00345-019-03055-4DOI Listing
February 2020

Augmentation Phalloplasty for Acquired Penile Shortening: A Systematic Review of Techniques, Outcomes, Patient Satisfaction, and Limitations.

J Sex Med 2020 02 9;17(2):331-341. Epub 2019 Dec 9.

Division of Plastic Surgery, Department of Surgery, Mayo Clinic, Rochester, MN, USA.

Introduction: Although an infrequent cause of small penile size in adult men, acquired penile shortening represents a particular reconstructive challenge due to preexisting penile anatomic deformities.

Aim: With numerous techniques being performed, the purpose of our study is to assess available literature on length enhancement procedures used for acquired penile shortening deformities.

Methods: A systematic review was performed using the guidelines outlined in the Preferred Reporting Items for Systematic reviews and Meta-analyses. Read More

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http://dx.doi.org/10.1016/j.jsxm.2019.11.260DOI Listing
February 2020

Re: Plication Techniques in Peyronie's Disease: New Developments.

Authors:
Allen D Seftel

J Urol 2020 03 10;203(3):448. Epub 2019 Dec 10.

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http://dx.doi.org/10.1097/JU.0000000000000668.04DOI Listing

EFFICIENCY EVALUATION OF COMBINED THERAPEUTIC APPROACH TO THE TREATMENT OF PEYRONIE'S DISEASE.

Authors:
Y Zasieda

Georgian Med News 2019 Oct(295):20-24

Clinic "Men's Health", Kyiv, Ukraine.

Objective - The search of effective approaches to Peyronie's disease treatment remains an urgent problem. In this study we had evaluated the efficiency of platelet-rich plasma therapy, low-intensity shock wave therapy, local negative-pressure therapy. On a basis of Men's Health Clinic (Kyiv, Ukraine), 23 patients with PD (ICD-10: N48. Read More

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October 2019

Penile prosthesis implant in the special populations: diabetics, neurogenic conditions, fibrotic cases, concurrent urinary continence surgery, and salvage implants.

Authors:
Eric Chung

Asian J Androl 2020 Jan-Feb;22(1):39-44

AndroUrology Centre, Brisbane, QLD 4000, Australia.

Penile prosthesis implant (PPI) remains an effective and safe treatment option for men with erectile dysfunction (ED). However, PPI surgery can be associated with a higher risk of complications in certain populations. This article provides a critical review of relevant publications pertaining to PPI in men with diabetes, significant corporal fibrosis, spinal cord injury, concurrent continence surgery, and complex salvage cases. Read More

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http://dx.doi.org/10.4103/aja.aja_127_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6958981PMC
December 2019

Penistraktionstherapie bei Induratio penis plastica: Vakuumsystem effektiv und sicher.

Authors:

Aktuelle Urol 2019 12 26;50(6):574. Epub 2019 Nov 26.

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http://dx.doi.org/10.1055/a-0841-8430DOI Listing
December 2019

Radiation Therapy for Benign Disease: Keloids, Macular Degeneration, Orbital Pseudotumor, Pterygium, Peyronie Disease, Trigeminal Neuralgia.

Hematol Oncol Clin North Am 2020 Feb 31;34(1):229-251. Epub 2019 Oct 31.

Radiation Oncology Department, Winship Cancer Institute of Emory University, 1365 Clifton Road Northeast, Building C, Atlanta, GA 30322, USA.

Although the use of ionizing radiation on malignant conditions has been well established, its application on benign conditions has not been fully accepted and has been inadequately recognized by health care providers outside of radiation therapy. Most frequently, radiation therapy in these benign conditions is used along with other treatment modalities, such as surgery, when the condition causes significant disability or could even lead to death. Radiation therapy can be helpful for inflammatory/proliferative disorders. Read More

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http://dx.doi.org/10.1016/j.hoc.2019.09.006DOI Listing
February 2020

Verapamil and collagenase differentially affect collagen metabolism in experimental model of Peyronie's disease.

Mol Cell Probes 2020 02 13;49:101488. Epub 2019 Nov 13.

Department of Medicinal Chemistry, Medical University of Bialystok, Adama Mickiewicza 2D, 15-222, Bialystok, Poland. Electronic address:

Objectives: Peyronie's disease (PD) is accompanied by remodelling of connective tissue into fibrotic plaque. Treatment of the inflammatory and fibrotic phases of the disease is not established. The aim of the study was to evaluate the effect of verapamil (VER) and bacterial collagenase (COLL) on collagen metabolism and cell migration in fibroblasts with experimental wound healing and inflammation as an in vitro model of PD. Read More

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http://dx.doi.org/10.1016/j.mcp.2019.101488DOI Listing
February 2020

Peyronie's disease: clinical treatment.

Rev Assoc Med Bras (1992) 2019;65(10):1231-1239. Epub 2019 Nov 7.

Coordenador do Programa Diretrizes da Associação Médica Brasileira, São Paulo, SP, Brasil.

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http://dx.doi.org/10.1590/1806-9282.65.10.1231DOI Listing
January 2020

The Effects of Collagenase Clostridium histolyticum on Plantar Fibromatosis: A Case Study.

J Foot Ankle Surg 2019 Nov;58(6):1281-1284

Pathologist, Crozer Keystone Health System, Upland, PA.

Plantar fibromatosis, also known as Ledderhose's disease, is a rare disorder of benign fibroblast proliferation involving the plantar aponeurosis (i.e., plantar fascia). Read More

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http://dx.doi.org/10.1053/j.jfas.2019.04.006DOI Listing
November 2019

Antioxidant Mechanism of Xiaojin Pill () for Treatment of Peyronie's Disease in Rats Based on Matrix Metalloproteinases.

Chin J Integr Med 2019 Sep 24;25(9):671-676. Epub 2019 Oct 24.

Department of Andrology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, 100091, China.

Objective: To evaluate the effects of Xiaojin Pill () in the treatment of Peyronie's disease (PD) in a rat model.

Methods: Twenty-four male Sprague-Dawley rats were randomly divided into four groups with 6 in each: sham operation, PD model, vehicle control and Xiaojin Pill groups. The rats in the sham operation group received penile tunica albsginea (TA) injection with 50 μL vehicle, while the rats in the other 3 groups received 50 μL penile TA injection of 50 μg transforming growth factor (TGF)-β1. Read More

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http://dx.doi.org/10.1007/s11655-019-3203-7DOI Listing
September 2019

Collagenase Clostridium Histolyticum: A Review in Peyronie's Disease.

Authors:
Sheridan M Hoy

Clin Drug Investig 2020 Jan;40(1):83-92

Springer Nature, Private Bag 65901, Mairangi Bay, Auckland, 0754, New Zealand.

Collagenase Clostridium Histolyticum (hereafter referred to as CCH) [Xiaflex; Xiapex] is a mixture of two Clostridium histolyticum collagenases [AUX-I (a Class I clostridial collagenase) and AUX-II (a Class II clostridial collagenase)]. Administered by intralesional injection, it is available in various countries for the treatment of adult men with Peyronie's disease (PD). In two double-blind, multinational, phase III studies, CCH improved the physical (penile curvature) and psychological (patient-reported bother) aspects of PD in adult men. Read More

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http://dx.doi.org/10.1007/s40261-019-00867-5DOI Listing
January 2020