102,772 results match your criteria Perspectives on sexual and reproductive health[Journal]
Drug Alcohol Depend 2018 Nov 13;194:527-532. Epub 2018 Nov 13.
Department of Health, Behavior, and Society, Johns Hopkins Bloomberg School of Public Health, 624 N. Broadway, Hampton House 163, Baltimore, MD, USA.
Background: The opioid epidemic is one of the greatest public health crises of our times, driven increasingly by synthetic opioids such as fentanyl in the heroin supply. The implementation of drug checking in community settings has the potential to reduce the burden of fatal overdose, provide harm reduction education around safer drug consumption, and increase health access among people who use drugs (PWUD). To inform program development, we explored stakeholder opinions on drug checking technologies and implementation considerations. Read More
Pharmacol Res 2018 Dec 11. Epub 2018 Dec 11.
Department of Animal Science & Technology and BET Research Institute, Chung-Ang University, Anseong, Gyeonggi-do, 17546, Republic of Korea. Electronic address:
With the continued increase in global human population, diverse contraception approaches have become increasingly essential, including non-hormonal male contraception. Non-hormonal approaches to contraception are very convenient; however, such options are limited because data regarding the identification and characterization of tissue/cell-specific targets and appropriate small molecule candidate contraceptives are lacking. Based on in-silico studies of genomics, transcriptomics, and proteomics, performed by mining datasets in PubMed, we first reviewed testis-, epididymis-, and germline cell-specific genes/proteins, with the aim of presenting evidence that many of these could become 'druggable' targets for the development of non-hormonal male contraceptives in the future. Read More
Sci Total Environ 2018 Dec 5;657:509-516. Epub 2018 Dec 5.
China National Center for Food Safety Risk Assessment, Beijing 100022, China. Electronic address:
Hand, foot and mouth disease (HFMD) remains an increasing public health concern. The spatiotemporal variation of HFMD can be represented from multiple-perspectives, and it may be driven by different dominant factors. In this study, the HFMD cases in children under the age of five years in each county in Henan province, China, from 2009 to 2013 were assessed to explore the integrative spatiotemporal patterns of HFMD and investigate their driving factors. Read More
Semin Cell Dev Biol 2018 Dec 11. Epub 2018 Dec 11.
Departamento de Farmacologia, Instituto de Ciências Biológicas, Universidade Federal de Goiás, Goiânia, Brazil. Electronic address:
Stroke consists of an abrupt reduction of cerebral blood flow resulting in hypoxia that triggers an excitotoxicity, oxidative stress, and neuroinflammation. After the ischemic process, neural precursor cells present in the subventricular zone of the lateral ventricle and subgranular zone of the dentate gyrus proliferate and migrate towards the lesion, contributing to the brain repair. The neurogenesis is induced by signal transduction pathways, growth factors, attractive factors for neuroblasts, transcription factors, pro and anti-inflammatory mediators and specific neurotransmissions. Read More
J Addict Med 2018 Dec 13. Epub 2018 Dec 13.
Department of Health Policy and Management, University of Pittsburgh Graduate School of Public Health (MJ); University of Pittsburgh School of Medicine (SM, CH); Magee-Womens Research Institute, University of Pittsburgh (JCC); Departments of Obstetrics, Gynecology and Reproductive Sciences and Internal Medicine, University of Pittsburgh, Pittsburgh, PA (JCC).
Objective: In many states, health care providers are legally required to report pregnant women who use substances, or infants affected by prenatal substance use, to child welfare authorities. The objective of this study was to characterize obstetric and pediatric providers' perceptions of and experiences with policies requiring mandatory reporting of prenatal substance use to child welfare authorities.
Methods: We conducted a qualitative interview study among 20 obstetric and pediatric providers to elicit participants' perspectives about and experience with current policy requiring mandatory reporting of prenatal substance use. Read More
J Oncol Pract 2018 Dec 14:JOP1800162. Epub 2018 Dec 14.
UCLA Jonsson Comprehensive Cancer Center; UCLA Anderson School of Management; UCLA Schools of Medicine and Public Health, Los Angeles; UC Davis Center for Healthcare Policy and Research, Davis, CA; and University of Texas Health Sciences Center, San Antonio, TX.
Purpose:: According to the Institute of Medicine, high-quality cancer care should include effective communication between clinicians and patients about the risks and benefits, expected response, and impact on quality of life of a recommended therapy. In the delivery of oncology care, the barriers to and facilitators of communication about potential long-term and late effects, post-treatment expectations, and transition to survivorship care have not been fully defined.
Patients And Methods:: We collected qualitative data through semistructured interviews with medical oncologists and focus groups with breast cancer survivors and applied the Theoretical Domains Framework to systematically analyze and identify the factors that may influence oncologists' communication with patients with breast cancer about the long-term and late effects of adjuvant therapy. Read More
Chemistry 2018 Dec 14. Epub 2018 Dec 14.
Universite de Montpellier, IBMM, Place Eugène Bataillon, 34095, Montpellier, FRANCE.
A solvent-assisted mechanochemical approach to access symmetrical and mixed dinucleoside 5,5'-polyphosphates is reported. Under ball-milling conditions, nucleoside 5'-monophosphates are quantitatively activated using N,N'-carbonyldiimidazole into their phosphorimidazolide derivatives. The addition of a nucleoside 5'-mono, di or triphosphate directly leads to the formation of the corresponding dinucleotides. Read More
J Adv Nurs 2018 Dec 14. Epub 2018 Dec 14.
Warwick Research in Nursing, University of Warwick and Oxford Trauma, Kadoorie Centre, NDORMS, University of Oxford and Oxford University Hospitals NHS Trust.
Aim: To explore assessment on a hospital ward for older people from the perspectives of patients and healthcare professionals.
Design: A qualitative study drawing on grounded theory was undertaken between February 2015 - January 2016.
Methods: Interviews with 15 patients and 22 healthcare professionals, a focus group with six healthcare professionals, 45 hours of observation and review of 18 sets of patient notes. Read More
Genes Brain Behav 2018 Dec 13:e12544. Epub 2018 Dec 13.
Genetics of Cognition laboratory, Department of Neuroscience and Brain Technologies, Istituto Italiano di Tecnologia, Genova, Italy.
Emotion recognition represents the ability to encode an ensemble of sensory stimuli providing information about the emotional state of another individual. This ability is not unique to humans. An increasing number of studies suggests that many aspects of higher order social functions, including emotion recognition, might be present in species ranging from primates to rodents, indicating a conserved role of these abilities in social animals. Read More
Br J Health Psychol 2018 Dec 13. Epub 2018 Dec 13.
School of Psychological Sciences, Tel Aviv University, Israel.
Objectives: Since behavioural risk factors are the foremost causes of disability and premature mortality, developing new perspectives for understanding them is of utmost importance. This paper describes an innovative approach that conceptualizes health-related behaviours as nodes in a weighted network.
Design & Methods: Using self-reported data from a representative sample (n = 374), a network of 37 health behaviours was analysed, with the aim of identifying 'central' nodes, that is, behaviours that are likely to co-occur with others and potentially influence them. Read More
Gerodontology 2018 Dec 14. Epub 2018 Dec 14.
Cooperative Research Centre for Oral Health Science Melbourne Dental School, University of Melbourne, Melbourne, Victoria, Australia.
Aims: The aim of this study was to explain through the life-course and life-span perspectives of developmental regulation theory the controls on dental experiences and beliefs throughout the lives of older people in Guangzhou and Hong Kong.
Background: Dental diseases and disabilities among older people are serious public health concerns in China.
Methods: A facilitator conducted eight focus groups, three in Hong Kong and five in Guangzhou, involving a total of 51 participants. Read More
Med Educ 2018 Dec 13. Epub 2018 Dec 13.
Nutrition, Dietetics and Food, School of Clinical Sciences, Faculty Medicine, Nursing and Health Sciences, Monash University, Clayton, Victoria, Australia.
Background: The skills and qualities of effective clinical educators are linked to improved student learning and ultimately patient care; however, within allied health these have not yet been systematically summarised in the literature.
Aims: To identify and synthesise the skills and qualities of clinical educators in allied health and their effect on student learning and patient care.
Method: A systematic search of the literature was conducted across five electronic databases in November 2017. Read More
Small 2018 Dec 13:e1804371. Epub 2018 Dec 13.
School of Materials Science and Engineering, Nanjing University of Science and Technology, Nanjing, 210094, China.
Amorphous metal oxides (AMOs) have aroused great enthusiasm across multiple energy areas over recent years due to their unique properties, such as the intrinsic isotropy, versatility in compositions, absence of grain boundaries, defect distribution, flexible nature, etc. Here, the materials engineering of AMOs is systematically reviewed in different electrochemical applications and recent advances in understanding and developing AMO-based high-performance electrodes are highlighted. Attention is focused on the important roles that AMOs play in various energy storage and conversion technologies, such as active materials in metal-ion batteries and supercapacitors as well as active catalysts in water splitting, metal-air batteries, and fuel cells. Read More
J Child Adolesc Psychiatr Nurs 2018 Dec 12. Epub 2018 Dec 12.
Oregon Health & Science University (OSHU), La Grande Campus, Portland, Oregon.
Problem: A common clinical approach to children with attention deficit hyperactivity disorder (ADHD) is to view them through an adult-proxy report of problems. There is little evidence on how children with ADHD evaluate their life satisfaction, how their evaluations compare with unaffected children, or how their perspectives might inform clinical practice.
Methods: A parallel convergent mixed-methods design was used to interview 20 children (aged, 7-11 years) with ADHD. Read More
Eur J Cancer Care (Engl) 2018 Dec 12:e12977. Epub 2018 Dec 12.
Institute of Nursing and Health Research, Ulster University, Coleraine, UK.
Access and recruitment barriers may have contributed to the underrepresentation of Black African/Caribbean men and their partners in current psychosocial research related to prostate cancer survivors. Whilst some studies have explored recruitment barriers and facilitators from participants' perspectives, little is known from researchers' point of view. This paper aimed to address this gap in the literature. Read More
Dev Neurobiol 2018 Dec 12. Epub 2018 Dec 12.
Department of Biology, University of North Florida, Jacksonville, Florida.
Radial glial cells are crucial in vertebrate neural development and regeneration. It has been recently proposed that this neurogenic cell type might be older than the chordate lineage itself and might have been present in the last common deuterostome ancestor. Here, we summarize the results of recent studies on radial glia in echinoderms, a highly regenerative phylum of marine invertebrates with shared ancestry to chordates. Read More
Risk Anal 2018 Dec 12. Epub 2018 Dec 12.
National Center for Atmospheric Research, Boulder, CO, USA.
As emphasis on interdisciplinary and convergent research grows, researchers and institutions can benefit from additional insights into how to build interdisciplinary integration within the research process. This article presents signs of successful interdisciplinary research and proposes strategies that researchers can implement to help create and sustain integration across fields. Drawing on the authors' experiences, other examples from hazards research, and the literature on interdisciplinarity, the article asserts that successful interdisciplinary research incorporates full intellectual participation by each contributing field, forming a multiway partnership. Read More
Nurs Health Sci 2018 Dec 11. Epub 2018 Dec 11.
Young Psychiatric Clinic, New Taipei, Taiwan.
Autism spectrum disorder has only recently been recognized as a developmental disability in Taiwan. We conducted an exploratory qualitative descriptive study with children (n = 14, mean age = 13.57 years) and their parents to understand stressors experienced by children with autism spectrum disorder in Taiwan. Read More
Acta Ophthalmol 2018 Dec 10. Epub 2018 Dec 10.
Liverpool Ocular Oncology Research Group, Department of Molecular and Clinical Cancer Medicine, Institute of Translational Medicine, University of Liverpool, Liverpool, UK.
Purpose: To investigate the cytotoxic effect of bleomycin, mitomycin C (MMC) and Fluorouracil (5-FU) in combination with electroporation (EP) on human conjunctival melanoma (CM) and normal conjunctival cell lines using 2D and 3D cell culture systems in vitro.
Methods: Two CM (CRMM1, CRMM2) and one normal conjunctival epithelial cell line (HCjE-Gi) were treated with various EP conditions and increasing concentrations of 5-FU, MMC and bleomycin. Cell survival was assessed by MTT viability assay. Read More
Insect Sci 2018 Dec 10. Epub 2018 Dec 10.
Embrapa Mandioca e Fruticultura, 44380-000, Cruz das Almas, BA, Brazil.
Bacillus thuringiensis (Bt) toxins are effective in controlling insect pests either through the spraying of products or when expressed in transgenic crops. The discovery of endophytic Bt strains opened new perspectives for studies aimed at the control of sap-sucking insects, such as the Asian citrus psyllid Diaphorina citri Kuwayama (Hemiptera: Liviidae), a vector of 'Candidatus Liberibacter spp.', associated with citrus huanglongbing (HLB). Read More
AIDS Rev 2018 ;20(4):226-235
Research Institute for Evaluation and Public Policies (IRAPP); Universitat Internacional de Catalunya, Barcelona, Spain.
The main data on HIV in high-income countries from the standpoint of health economics are updated and discussed. Specifically, issues surrounding the economic impact of HIV are addressed for health care and occupational perspectives. We review the main epidemiological data on the prevalence of disease and foreseeable changes in patterns within the coming years. Read More
Oncol Nurs Forum 2019 Jan;46(1):49-58
City of Hope Comprehensive Cancer Center.
Purpose: To explore palliative care and oncology clinicians' perspectives on current challenges and facilitating factors in meeting the spiritual needs of patients with lung cancer and family caregivers. This study was conducted in preparation for a community-based lung cancer palliative care intervention.
Participants & Setting: 19 oncology and palliative care clinicians in three outpatient Kaiser Permanente sites in southern California. Read More
Ugeskr Laeger 2018 Dec;180(50)
The taste buds seem to have a gatekeeper function to avoid uneatable or potentially toxic food and to be aware of dysfunctional sense of taste. However, taste has a wider function than avoiding illness. It is also the precondition for tastiness and pleasure, which is even as important in a health-promoting context. Read More
Pediatr Rheumatol Online J 2018 Dec 14;16(1):78. Epub 2018 Dec 14.
Pediatric Rheumatology, Seattle Children's Hospital, University of Washington, Seattle, WA, USA.
Background: Chronic nonbacterial osteomyelitis (CNO) is an autoinflammatory bone disorder that if left untreated can result in bone destruction and severe continuing pain due to persistent inflammation. The impact this chronic disease has on the daily lives of affected children and their families is not well known. The purpose of this study is to understand the disease burden and socioeconomic and psychological impact of CNO from the patients' and families' perspectives and identify areas of improvement for patient care and reduced disease burden based on patients' and families' responses. Read More
BMC Complement Altern Med 2018 Dec 14;18(1):334. Epub 2018 Dec 14.
Africa Mental Health Foundation and Department of Psychiatry, University of Nairobi, Mawensi Road, Off Elgon road, Mawensi Garden, P.O. BOX 48423-00100, Nairobi, Kenya.
Background: Involvement of traditional health practitioners (THPs) in the form of collaboration with the formal health care system is suggested to improve the pathways to mental health care in Kenya, yet understanding of the current traditional practice and THPs' perspectives is lacking. The aim of this study was to explore the views of THPs with respect to their mental health practice.
Methods: This study qualitatively explored the views of THPs, using four focus group discussions (FDGs) each consisting of 8-10 traditional and faith healers, resulting in a total of 36 participants. Read More
BMC Fam Pract 2018 Dec 14;19(1):197. Epub 2018 Dec 14.
Centre for Academic Primary Care, Oakfield House, Oakfield Grove, Clifton, Bristol, BS8 2BN, UK.
Background: Depression is the leading cause of disability worldwide, and is a major contributor to the overall global burden of disease. The number of prescriptions for antidepressants has risen dramatically in recent years yet up to 50% of patients who are treated for depression with antidepressants do not report feeling better as a result of treatment, and do not show the desired improvement on depression measures. We report a qualitative study embedded in a trial of second antidepressant for people who had not responded to one antidepressant, exploring the acceptability of a combination of antidepressants from the perspectives of both patients and practitioners, together with experiences of participating in a clinical trial. Read More
Qual Health Res 2018 Dec 14:1049732318817047. Epub 2018 Dec 14.
5 Centre for Chronic Disease Control & Public Health Foundation of India, Gurgaon, Haryana, India.
Tobacco cessation is an important intervention to reduce mortality from ischemic heart disease, the leading cause of death in India. In this study, we explored facilitators, barriers, and cultural context to tobacco cessation among acute coronary syndrome (ACS, or heart attack) patients and providers in a tertiary care institution in the south Indian state of Kerala, with a focus on patient trajectories. Patients who quit tobacco after ACS expressed greater understanding about the link between tobacco and ACS, exerted more willpower at the time of discharge, and held less fatalistic beliefs about their health compared to those who continued tobacco use. Read More
Pflege 2018 Dec 14:1-10. Epub 2018 Dec 14.
2 Institut für Pflegewissenschaft, Medizinische Fakultät der Albert-Ludwigs-Universität, Freiburg i. B.
Career prospects of graduate Bachelor nursing degree programs - Results of a nationwide study in Germany Abstract.
Background: Graduates of Bachelor nursing degree programs are available on the labour market for a few years. Currently, there is no empirical evidence or reports on different fields of these academically prepared nurses in Germany. Read More
Gift Child Q 2017 Oct 31;61(4):343-360. Epub 2017 Jul 31.
University of British Columbia, Vancouver, British Columbia, Canada.
After nearly a century of development, gifted education has evolved into a complex educational discipline with well thought out pedagogy and research agendas. However, while the number of studies escalates, the field as a whole has been criticized for producing fragmented and piecemeal results. One of the reasons for these shortfalls is that the field has invested little in meta-theoretical aspects, such as historical perspectives and philosophical foundations. Read More
J Health Pollut 2015 Dec 21;5(9):3-11. Epub 2015 Dec 21.
Department of Management and Engineering- Environmental Technology and Management, Linköping University, Linköping, Sweden.
Background: E-waste has been identified as the fastest growing waste stream in the world at present. Rapid socio-economic development and technological advancement are the main drivers of this trend. The hazardous chemical components of e-waste have potential adverse impacts on ecosystems and human health if not managed properly. Read More
Sante Publique 2018 Sep;S2(HS2):145-156
Introduction: Health literacy refers to the competences and resources required by individuals to meet the complex demands of health in modern society. This paper describes and analyses the health literacy profiles of type 2 diabetic patients included in a 2-year long self-management education programme.
Methods: Nested in the ERMIES randomized controlled trial conducted in Reunion island, the ERMIES Ethnosocio study explored health literacy by means of two complementary approaches: description of health literacy profiles via the French version of the multidimensional ?Health Literacy Questionnaire?, and a socio-anthropological perspective based on 40 semi-structured interviews carried out in 2012 and then in 2015. Read More
Methods Mol Biol 2019 ;1883:25-48
German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
In this chapter, we review the problem of network inference from time-course data, focusing on a class of graphical models known as dynamic Bayesian networks (DBNs). We discuss the relationship of DBNs to models based on ordinary differential equations, and consider extensions to nonlinear time dynamics. We provide an introduction to time-varying DBN models, which allow for changes to the network structure and parameters over time. Read More
J Technol Behav Sci 2018 19;3(4):294-300. Epub 2018 Jun 19.
Department of Psychology, Bahir Dar University, Bahir Dar, Ethiopia.
Recent findings show teenagers use social media increasingly in their daily life. There is also a consensus that social media have both pros and perils on students' academic affairs. The objective of this study is to assess how Ethiopian secondary school students perceive the benefits and risks associated with social media use. Read More
Glob Pediatr Health 2018 4;5:2333794X18817134. Epub 2018 Dec 4.
East Carolina University, Greenville, NC, USA.
Family-based interventions are the current standard for the treatment of pediatric obesity, yet the details of how providers are involving family members, and the barriers to family involvement, are largely unknown. The objective of this study is to describe how providers in pediatric weight management (PWM) involve family members, identify barriers to family involvement, and how they address challenging family dynamics. A cross-sectional survey was administered to PWM centers/clinics and their providers in the United States and Canada. Read More
Glob Qual Nurs Res 2018 Jan-Dec;5:2333393618815006. Epub 2018 Dec 4.
Åbo Akademi University, Vaasa, Finland.
The aim of this study was to describe researchers' experiences of participation in reflective dialogues through a hermeneutic application research approach. The aim was also to describe their perspectives on application, that is, the inner appropriation and application of theory into practice and vice versa. Twenty-one clinical coresearchers and four scientific researchers participated in reflective dialogues in a project on ethical sustainable caring cultures, in which an application research approach was used. Read More
Front Public Health 2018 28;6:338. Epub 2018 Nov 28.
Policy Studies Center of the College of Public Policy, University of Texas at San Antonio, San Antonio, TX, United States.
Menstruation poses particular challenges for women with intellectual disability (ID). In low-and middle-income countries, where these women do not have access to facilities and resources for adequate menstrual care, hysterectomy could be considered as an ethically acceptable procedure. We conducted the first systematic review to identify what constitutes best practice for menstrual hygiene in women with ID and explored the perspectives of actors involved in the hysterectomy decision. Read More
Front Oncol 2018 28;8:563. Epub 2018 Nov 28.
Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University, Guangzhou, China.
Head and neck cancer is the 6th most common malignancy worldwide and urgently requires novel therapy methods to change the situation of low 5-years survival rate and poor prognosis. Targeted therapy provides more precision, higher efficiency while lower adverse effects than traditional treatments like surgery, radiotherapy, and chemotherapy. Blockade of PD-1 pathway with antibodies against PD-1 or PD-L1 is such a typical targeted therapy which reconstitutes anti-tumor activity of T cell in treatments of cancers, especially those highly expressing PD-L1, including head and neck cancers. Read More
J Pharm Investig 2018 28;48(1):43-60. Epub 2017 Nov 28.
College of Pharmacy and Integrated Research Institute for Drug Development, Dongguk University-Seoul, 32 Dongguk-lo, Ilsandong-gu, Goyang, Gyonggi-do 10326 Republic of Korea.
Nanomedicines have evolved into various forms including dendrimers, nanocrystals, emulsions, liposomes, solid lipid nanoparticles, micelles, and polymeric nanoparticles since their first launch in the market. Widely highlighted benefits of nanomedicines over conventional medicines include superior efficacy, safety, physicochemical properties, and pharmacokinetic/pharmacodynamic profiles of pharmaceutical ingredients. Especially, various kinetic characteristics of nanomedicines in body are further influenced by their formulations. Read More
Sustain Sci 2018 25;13(6):1533-1547. Epub 2018 May 25.
5Institute for Development Studies, Brighton, UK.
The United Nations formulated the sustainable development goals (SDGs) in 2015 as a comprehensive global policy framework for addressing the most pressing social and environmental challenges currently facing humanity. In this paper, we analyse SDG 12, which aims to "ensure sustainable consumption and production patterns." Despite long-standing political recognition of this objective, and ample scientific evidence both on its importance and on the efficacy of various ways of promoting it, the SDGs do not provide clear goals or effective guidance on how to accomplish this urgently needed transformation. Read More
Sustain Sci 2018 17;13(6):1519-1531. Epub 2018 Jul 17.
10Basque Centre for Climate Change, University of the Basque Country (UPV-EHU), Sede Building 1, 1st Floor, Scientific Campus, Leioa, 48940 Bilbao, Spain.
Sustainability is a key challenge for humanity in the context of complex and unprecedented global changes. Future Earth, an international research initiative aiming to advance global sustainability science, has recently launched knowledge-action networks (KANs) as mechanisms for delivering its research strategy. The research initiative is currently developing a KAN on "natural assets" to facilitate and enable action-oriented research and synthesis towards natural assets sustainability. Read More
Oncol Lett 2018 Dec 9;16(6):7091-7096. Epub 2018 Oct 9.
Department of Molecular Biotechnology and Health Sciences, Center for Experimental Research and Medical Studies, University of Torino, I-10126 Torino, Italy.
Recent studies reported the expression of anaplastic lymphoma kinase (ALK) in malignant melanomas. The aim of this study was to investigate whether ALK expression is associated with specific clinical and molecular characteristics of melanoma metastases, and to evaluate its correlation with survival outcomes. Seventy-one patients with metastatic melanoma were investigated. Read More
Clin Exp Neuroimmunol 2018 Nov 23;9(4):211-218. Epub 2018 Sep 23.
RIKEN Center for Brain Science Laboratory for Proteolytic Neuroscience Wako Japan.
Alzheimer's disease (AD) is the most common type of neurocognitive disorder. Although both amyloid β peptide deposition and neurofibrillary tangle formation in the AD brain have been established as pathological hallmarks of the disease, many other factors contribute in a complex manner to the pathogenesis of AD before clinical symptoms of the disease become apparent. Longitudinal pathophysiological processes cause patients' brains to exist in a state of chronic neuroinflammation, with glial cells acting as key regulators of the neuroinflammatory state. Read More
Nat Rev Neurosci 2018 Dec 13. Epub 2018 Dec 13.
Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.
Narcolepsy is the most common neurological cause of chronic sleepiness. The discovery about 20 years ago that narcolepsy is caused by selective loss of the neurons producing orexins (also known as hypocretins) sparked great advances in the field. Here, we review the current understanding of how orexin neurons regulate sleep-wake behaviour and the consequences of the loss of orexin neurons. Read More
Sci Rep 2018 Dec 13;8(1):17836. Epub 2018 Dec 13.
Department of Biochemistry and Molecular biology, Shanxi Medical University, Taiyuan, China.
The dysregulation of transcription factors has an important impact on the oncogenesis and tumor progression. Nonetheless, its functions in colorectal cancer metastasis are still unclear. In this study, four transcription factors (HNF4A, HSF1, MECP2 and RAD21) were demonstrated to be associated with the metastasis of colorectal cancer in both RNA and protein levels. Read More
J Natl Compr Canc Netw 2018 Dec;16(12):1491-1498
Scientific Center for Quality of Healthcare, and Department of Otolaryngology, Head and Neck Surgery, Radboud University Medical Center, Radboud Institute for Health Sciences, Nijmegen; Department of Otorhinolaryngology, Head and Neck Surgery, Erasmus MC Cancer Institute, Rotterdam; Department of Medical Oncology, Antoni van Leeuwenhoek Nederlands Kanker Instituut, Amsterdam; Department of Oral and Maxillofacial Surgery, Rijnstate Hospital, Arnhem; Department of Oral and Maxillofacial Surgery, Noordwest Ziekenhuisgroep, Alkmaar; Department of Oral and Maxillofacial Surgery, Maastricht University Medical Center, Maastricht; Department of Research, Netherlands Comprehensive Cancer Organisation, Utrecht; Department of Epidemiology, University of Groningen, University Medical Centre Groningen, Groningen; Department of Head and Neck Surgical Oncology, UMC Utrecht Cancer Centre, Utrecht; Department of Radiation Oncology (MAASTRO), GROW - School for Oncology and Developmental Biology, Maastricht University Medical Centre, Maastricht; Department of Oral and Maxillofacial Surgery, Medisch Spectrum Twente, Enschede; Department of Otolaryngology, Head and Neck Surgery, Elisabeth Tweesteden Ziekenhuis Tilburg, Tilburg; Department of Otorhinolaryngology, Head and Neck Surgery, Leiden University Medical Centre, Leiden; Department of Otolaryngology, Head and Neck Surgery, MC Haaglanden-Bronovo, The Hague; Department of Oral and Maxillofacial Surgery, Medical Centre Leeuwarden, Leeuwarden; Department of Otolaryngology, Head and Neck Surgery, VU University Medical Centre, Amsterdam; Department of Oral and Maxillofacial Surgery, University of Groningen, University Medical Centre Groningen, Groningen; Department of Head and Neck Surgery and Oncology, Antoni van Leeuwenhoek Nederlands Kanker Instituut, Amsterdam; Department of Oral and Maxillofacial Surgery, Academisch Medisch Centrum, Amsterdam Zuid-Oost; and Department of Oral and Maxillofacial Surgery, Radboud University Medical Centre, Radboud Institute for Health Sciences, Nijmegen, the Netherlands.
Monitoring and effectively improving oncologic integrated care requires dashboard information based on quality registrations. The dashboard includes evidence-based quality indicators (QIs) that measure quality of care. This study aimed to assess the quality of current integrated head and neck cancer care with QIs, the variation between Dutch hospitals, and the influence of patient and hospital characteristics. Read More
Eur Respir J 2018 Dec 13. Epub 2018 Dec 13.
Pulmonary Hypertension Association, Silver Spring, MD, USA.
The assessment of objective measurement of cardiopulmonary status has helped us achieve better clinical outcomes for patients and develop new therapies through to the point of market access; however, patient surveys indicate that more can be done to improve holistic care and patient engagement. In this multidisciplinary review, we examine how clinical teams can acknowledge and embrace the individual patient's perspective, and thus improve the care for individual patients suffering from pulmonary hypertension by cultivating the importance and relevance of health-related quality of life in direct clinical care. At the individual level, patients should be provided with access to accredited specialist centres which provide a multidisciplinary approach where there is a culture focused on narrative medicine, quality of life, shared decision making and timely access to palliative care, and where there is participation in education. Read More
Eur Respir J 2018 Dec 13. Epub 2018 Dec 13.
Cardiovascular Institute, Dept of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.
Clinical and translational research has played a major role in advancing our understanding of pulmonary hypertension (PH), including pulmonary arterial hypertension and other forms of PH with severe vascular remodelling ( chronic thromboembolic PH and pulmonary veno-occlusive disease). However, PH remains an incurable condition with a high mortality rate, underscoring the need for a better transfer of novel scientific knowledge into healthcare interventions. Herein, we review recent findings in pathology (with the questioning of the strict morphological categorisation of various forms of PH into pre- or post-capillary involvement of pulmonary vessels) and cellular mechanisms contributing to the onset and progression of pulmonary vascular remodelling associated with various forms of PH. Read More
Biochem Soc Trans 2018 Dec 13. Epub 2018 Dec 13.
Astbury Centre for Structural Molecular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, U.K.
The receptor tyrosine kinase family of fibroblast growth factor receptors (FGFRs) play crucial roles in embryonic development, metabolism, tissue homeostasis and wound repair via stimulation of intracellular signalling cascades. As a consequence of FGFRs' influence on cell growth, proliferation and differentiation, FGFR signalling is frequently dysregulated in a host of human cancers, variously by means of overexpression, somatic point mutations and gene fusion events. Dysregulation of FGFRs is also the underlying cause of many developmental dysplasias such as hypochondroplasia and achondroplasia. Read More