1,036 results match your criteria Personalized Medicine [Journal]


Metabolomic diagnostics and human digital image.

Per Med 2019 Feb 15. Epub 2019 Feb 15.

Department of Proteomics & Mass Spectrometry, Institute of Biomedical Chemistry, Pogodinskaya st 10, 119121, Moscow, Russia.

The existing clinical laboratory practice has limitations in terms of specificity and sensitivity of diagnosis, making the introduction of new methods in medicine more topical. Application of 'omics' technologies, especially metabolomics, allows overcoming these limitations. The composition of blood metabolites reflects the physical state of an organism at the molecular level. Read More

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http://dx.doi.org/10.2217/pme-2018-0066DOI Listing
February 2019

Functional polymorphism within miR-23a∼27a∼24-2 cluster confers clinical outcome of breast cancer in Pakistani cohort.

Per Med 2019 Feb 15. Epub 2019 Feb 15.

Department of Biotechnology, University of Malakand, Chakdara, Pakistan.

Aim: MicroRNAs (miRNAs) are small regulatory RNA molecules that control gene activity by base pairing with target messenger RNA leading to their cleavage or translational repression. Previous studies show an involvement of miRNAs in various diseases including cancer. Members of the Mir-23a cluster (MIR23A, MIR24-2 and MIR27A) are involved in breast cancer (BC). Read More

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http://dx.doi.org/10.2217/pme-2018-0059DOI Listing
February 2019

Preparing next-generation scientists for biomedical big data: artificial intelligence approaches.

Per Med 2019 Feb 14. Epub 2019 Feb 14.

Institute for Biomedical Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.

Personalized medicine is being realized by our ability to measure biological and environmental information about patients. Much of these data are being stored in electronic health records yielding big data that presents challenges for its management and analysis. Here, we review several areas of knowledge that are necessary for next-generation scientists to fully realize the potential of biomedical big data. Read More

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http://dx.doi.org/10.2217/pme-2018-0145DOI Listing
February 2019
1.132 Impact Factor

Multigene panel testing versus syndrome-specific germline testing for inherited cancer risk: 'a somewhat different way'.

Per Med 2019 Feb 11. Epub 2019 Feb 11.

Dana-Farber Cancer Institute, Department of Medical Oncology, Boston, MA 02215, USA.

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http://dx.doi.org/10.2217/pme-2018-0109DOI Listing
February 2019
1 Read

The importance of real-world data to precision medicine.

Authors:
Dipak Kalra

Per Med 2019 Feb 6. Epub 2019 Feb 6.

Department of Medical Informatics and Statistics, University of Gent, Gent 9000, Belgium.

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http://dx.doi.org/10.2217/pme-2018-0120DOI Listing
February 2019

Screening of NogoA/NTR-related differential genes in rat sciatic nerve injury signal pathway.

Per Med 2019 Jan 29. Epub 2019 Jan 29.

Department of Hand Surgery, Yantaishan Hospital, Yantai, PR China.

Aim: To screen the differential genes in NogoA/NTR-related pathways that associate with sciatic nerve injury.

Results: There was no difference in the expression of NogoA, NTR and Ntrk2. Differential genes existed in 11 differential pathways that include NogoA, NTR and Ntrk2. Read More

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http://dx.doi.org/10.2217/pme-2018-0088DOI Listing
January 2019
1.132 Impact Factor

The association study of CLOCK gene polymorphisms with antidepressant effect in Chinese with major depressive disorder.

Per Med 2018 Dec 20. Epub 2018 Dec 20.

Department of Psychiatry, The First Hospital of Shanxi Medical University, Taiyuan 030000, People's Republic of China.

Aim: Major depressive disorder (MDD) is a common psychiatric disorder with a complicated pathogenesis and genetic predisposition. The objective of this article is to explore the relationship between the four SNPs of circadian locomotor output cycles kaput (CLOCK) gene (rs11932595, rs12504300, rs3805148, rs534654) and the efficacy of antidepressants. Materials & methods: This study enrolled a total of 600 patients, who met the DSM-V diagnostic criteria for MDD. Read More

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http://dx.doi.org/10.2217/pme-2018-0123DOI Listing
December 2018
2 Reads

Non-interventional cardiologists' perspectives on the role of pharmacogenomic testing in cardiovascular medicine.

Per Med 2018 Dec 13. Epub 2018 Dec 13.

Department of Pharmaceutical Sciences, University of Colorado Skaggs School of Pharmacy & Pharmaceutical Sciences, Aurora, CO, USA.

Aim: To evaluate factors influencing cardiologists' perspectives about pharmacogenomic (PGx) testing in clinical practice.

Patients & Methods: Semistructured interviews with practicing cardiologists were qualitatively analyzed to identify common themes.

Results: Five themes were identified among 16 cardiologists from four specialties (n = 5 general cardiology, n = 3 electrophysiology, n = 2 adult congenital and n = 6 heart failure/transplant): cardiologists' knowledge and needs, perceived clinical validity and utility of PGx testing, dissemination and management of PGx results, patient-related considerations and incidental findings. Read More

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http://dx.doi.org/10.2217/pme-2018-0099DOI Listing
December 2018
3 Reads

Welcome to the 16th volume of Personalized Medicine.

Authors:
Ebony Torrington

Per Med 2019 01 4;16(1):1-3. Epub 2018 Dec 4.

Future Science Group, Unitec House, 2 Albert Place, London N3 1QB, UK.

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http://dx.doi.org/10.2217/pme-2018-0131DOI Listing
January 2019
1 Read

From helices to health: undergraduate medical education in genetics and genomics.

Per Med 2018 Nov 29. Epub 2018 Nov 29.

Department of Medicine, Biomedical Genetics, Boston University School of Medicine, Boston, MA 02118, USA.

Rapid advances in genomic technologies combined with drastic reductions in cost and a growing number of clinical genomic tests are transforming medical practice. While enthusiasm about applications of precision medicine is high, the existing clinical genetics workforce is insufficient to meet present demands and will fall increasingly short as the use of genetic and genomic testing becomes more routine. To address this shortage, physicians in all areas of medicine will require genomic literacy. Read More

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http://dx.doi.org/10.2217/pme-2018-0081DOI Listing
November 2018
10 Reads

Continuing war on pain: a personalized approach to the therapy with nonsteroidal anti-inflammatory drugs and opioids.

Per Med 2018 Nov 28. Epub 2018 Nov 28.

St Catherine Specialty Hospital, 10000 Zagreb & 49210 Zabok, Croatia.

Successful pain management requires the delivery of analgesia with minimal risk of adverse drug reactions. Nonsteroidal anti-inflammatory drugs and opioids remain the mainstay of treatment for the majority of patients. Unfortunately, almost 50% of all patients experience inadequate pain relief and serious side effects. Read More

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http://dx.doi.org/10.2217/pme-2018-0116DOI Listing
November 2018
7 Reads

MTHFR polymorphisms as risk for male infertility in Pakistan and its comparison with socioeconomic status in the world.

Per Med 2019 01 23;16(1):35-49. Epub 2018 Nov 23.

Institute of Biomedical & Genetic Engineering (IB & GE), 24 Mauve Area, G9/1, Islamabad 44000, Pakistan.

Aim: 5,10-MTHFR-single nucleotide polymorphisms are important for normal functioning of the enzyme that plays a key role in DNA synthesis, folate metabolism and methylation reactions. Methodology & results: Male infertility association of C665T and A1298C polymorphisms was explored, this topic is still debatable. Infertile men (232) and controls (114) were genotyped and statistically analyzed. Read More

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http://dx.doi.org/10.2217/pme-2018-0045DOI Listing
January 2019
12 Reads

Characterization of farnesyl diphosphate farnesyl transferase 1 (FDFT1) expression in cancer.

Per Med 2019 01 23;16(1):51-65. Epub 2018 Nov 23.

Translational Genomics Research Institute (TGen), Phoenix, AZ 85004, USA.

Aim: To help characterize the FDFT1 gene and protein expression in cancer. Cholesterol represents an important structural component of lipid rafts. These specializations can be involved in pathways stimulating cell growth, survival and other processes active in cancer. Read More

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http://dx.doi.org/10.2217/pme-2016-0058DOI Listing
January 2019
11 Reads

The 'full stack' of healthcare innovation skills: combining clinical informatics with care delivery innovation.

Per Med 2019 01 22;16(1):9-14. Epub 2018 Nov 22.

Institute for Informatics (I2); Robert J. Terry Professor of General Medical Sciences, Washington University School of Medicine; Professor of Computer Science & Engineering, School of Engineering & Applied Science, Washington University St. Louis, MO 63110, USA.

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http://dx.doi.org/10.2217/pme-2018-0118DOI Listing
January 2019
9 Reads

Survivin c.-31G>C (rs9904341) gene transversion and urinary system cancers risk: a systematic review and a meta-analysis.

Per Med 2019 01 22;16(1):67-78. Epub 2018 Nov 22.

Anatomical Sciences Research Center, Kashan University of Medical Sciences, Kashan, Iran.

Aim: To investigate the possible association between survivin c.-31G>C (rs9904341) gene polymorphism and urinary system cancers by a meta-analysis approach.

Methods: Standard electronic literature databases were searched to find eligible studies. Read More

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https://www.futuremedicine.com/doi/10.2217/pme-2018-0053
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http://dx.doi.org/10.2217/pme-2018-0053DOI Listing
January 2019
10 Reads

APOE genotypes in Lebanon: distribution and association with hypercholesterolemia and Alzheimer's disease.

Per Med 2019 01 20;16(1):15-23. Epub 2018 Nov 20.

Department of Medical Laboratory Sciences, Faculty of Health Sciences, Beirut Arab University, Beirut, Lebanon.

Aim: We first investigated the distribution of APOE genotypes in Lebanese general population and Alzheimer's disease study (ADS) groups, and compared it with 1000 genomes populations. Then, we assessed eventual association between APOE genotypes, hypercholesterolemia and Alzheimer's disease (AD).

Materials & Methods: This cross-sectional study was conducted on 591 individuals. Read More

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http://dx.doi.org/10.2217/pme-2018-0067DOI Listing
January 2019
8 Reads

Preventive effects of oxytocin and oxytocin receptor in breast cancer pathogenesis.

Per Med 2019 01 19;16(1):25-34. Epub 2018 Nov 19.

Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Aim: Modifications of oxytocin (OT) concentration and OT receptor (OXTR) expression level have different effects on breast cancer-derived cells. This study was conducted to evaluate OT variation in breast cancer patients and to evaluate OXTR expression changes in breast cancer tissues.

Methods: The plasma concentrations of OT in both breast cancer patients and healthy individuals' samples were assessed. Read More

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https://www.futuremedicine.com/doi/10.2217/pme-2018-0009
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http://dx.doi.org/10.2217/pme-2018-0009DOI Listing
January 2019
11 Reads

Enabling biomarker discovery in Parkinson's disease using multiomics: challenges, promise and the future.

Per Med 2019 01 13;16(1):5-7. Epub 2018 Nov 13.

BERG LLC, Precision Medicine Division, Framingham, MA 01701, USA.

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http://dx.doi.org/10.2217/pme-2018-0115DOI Listing
January 2019
11 Reads

Importance of organoids for personalized medicine.

Per Med 2018 Nov 12;15(6):461-465. Epub 2018 Nov 12.

Internal Medicine I, Ulm University, Ulm, Germany.

The establishment of organoid culture systems represents a milestone on the route toward successful personalized medicine. This mini review provides an update on the current status of organoid technology and summarizes their applications in personalized medicine. Organoids can be defined as 3D structures derived either from pluripotent or organ restricted stem cells harboring the ability to mimic in vivo architecture and multi lineage differentiation of terminally differentiated tissues. Read More

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http://dx.doi.org/10.2217/pme-2018-0071DOI Listing
November 2018
1 Read

Correlation of IL28B rs12979860 genotype and gender with spontaneous clearance of HCV infection: a Pakistani cross-section study.

Per Med 2018 Nov 6;15(6):495-502. Epub 2018 Nov 6.

Faculty of Allied and Health Sciences, Imperial College of Business & Studies, Lahore, Pakistan 53720.

Aim: There is a strong correlation of IL28B rs12979860 genetic variations and gender with spontaneous clearance of hepatitis C virus (HCV) infection.

Materials & Methods: HCV-infected subjects were categorized into HCV spontaneous clearance (SC) group and chronic hepatitis C (CHC) group on the basis of anti-HCV antibodies and HCV RNA level and follow-up of 6 months. 35 subjects were classified in SC group and 165 subjects were classified in CHC group. Read More

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https://www.futuremedicine.com/doi/10.2217/pme-2018-0016
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http://dx.doi.org/10.2217/pme-2018-0016DOI Listing
November 2018
4 Reads
1.132 Impact Factor

Nuclear medicine and anatomic pathology in personalized medicine: a challenging alliance.

Per Med 2018 Nov 6;15(6):457-459. Epub 2018 Nov 6.

Department of Biomedicine & Prevention, University of Rome 'Tor Vergata', Via Montpellier, 1, Rome 00133, Italy.

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https://www.futuremedicine.com/doi/10.2217/pme-2018-0050
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http://dx.doi.org/10.2217/pme-2018-0050DOI Listing
November 2018
10 Reads

Biobanking initiatives to develop a national liver disease biobank facility in India.

Per Med 2018 Nov 5;15(6):531-541. Epub 2018 Nov 5.

National Liver Disease Biobank, Institute of Liver and Biliary Sciences, New Delhi, India.

Aim: India has a high hepatobiliary disease burden, yet very little research has been done in this field. A major roadblock in the translational research is the unavailability of quality biosamples with standardized clinical annotations. Having a national level biobank facility can circumvent the problem. Read More

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http://dx.doi.org/10.2217/pme-2018-0019DOI Listing
November 2018
1 Read
1.132 Impact Factor

Data integration strategies for predictive analytics in precision medicine.

Authors:
Lewis J Frey

Per Med 2018 Nov 2;15(6):543-551. Epub 2018 Nov 2.

Biomedical Informatics Center, Medical University of South Carolina, 135 Cannon Street/Suite 405K, MSC 200, Charleston, SC 29425, USA.

With the rapid growth of health-related data including genomic, proteomic, imaging and clinical, the arduous task of data integration can be overwhelmed by the complexity of the environment including data size and diversity. This report examines the role of data integration strategies for big data predictive analytics in precision medicine research. Infrastructure-as-code methodologies will be discussed as a means of integrating and managing data. Read More

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https://www.futuremedicine.com/doi/10.2217/pme-2018-0035
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http://dx.doi.org/10.2217/pme-2018-0035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277956PMC
November 2018
9 Reads

Precision in personalized prediction-based medicine.

Per Med 2018 Nov 2;15(6):467-470. Epub 2018 Nov 2.

Centre for Biosystems & Genome Network Medicine, Ioannina University, Ioannina, 45110, Greece.

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http://dx.doi.org/10.2217/pme-2018-0079DOI Listing
November 2018
1 Read

Predictive value of IL-28B rs12979860 variants for peg-IFN, sofosbuvir plus ribavirin treatment of HCV infection in Pakistani population.

Per Med 2018 Nov 1;15(6):503-510. Epub 2018 Nov 1.

Department of Medical Laboratory Sciences, Faculty of Health Allied Sciences Imperial College of Business Studies, Lahore, Pakistan.

Aim: The correlation of IL28-B genetic variants (rs12979860) with combinational therapy (peg-interferon, sofosbuvir plus ribavirin) of hepatitis C virus infection were studied in 154 chronic hepatitis C patients.

Methods & Results: The sustained virological response for efficient antiviral regimen was achieved in 75.32% treated individuals. Read More

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http://dx.doi.org/10.2217/pme-2018-0012DOI Listing
November 2018
2 Reads
1.132 Impact Factor

The Shiraz Breast Cancer Registry (SBCR): study design and primary reports.

Per Med 2018 Nov 30;15(6):471-479. Epub 2018 Oct 30.

Breast Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

Aim: This is a description of the largest breast cancer (BC) registry in Iran, termed the Shiraz Breast Cancer Registry (SBCR).

Methods: Data on baseline and clinical characteristics, socioeconomic status, imaging, physical examination, histopathology, treatment and prognosis have been recorded for each individual.

Results: Overall, 5937 were included in the report. Read More

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https://www.futuremedicine.com/doi/10.2217/pme-2018-0047
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http://dx.doi.org/10.2217/pme-2018-0047DOI Listing
November 2018
15 Reads

Expression analysis of a panel of cancer-testis antigens in bladder cancer.

Per Med 2018 Nov 26;15(6):511-520. Epub 2018 Oct 26.

Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran 1416753955, Iran.

Aim: Cancer-testis antigens (CTAs) have specific expression in gametogenic tissues and aberrant expression in cancers. Materials & methods: We assessed expression of five testis-specific genes namely KIF2B, CST8, TMEM225, RBM46, OAZ3 in bladder cancer tissues, adjacent non-neoplastic tissues and urinary cell pellets (UCPs) of bladder cancer patients compared with nonmalignant conditions.

Results: Expressions of all CTAs were higher in UCPs of bladder cancer patients compared with nonmalignant conditions. Read More

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https://www.futuremedicine.com/doi/10.2217/pme-2018-0049
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http://dx.doi.org/10.2217/pme-2018-0049DOI Listing
November 2018
16 Reads

Oxidized-LDL is a useful marker for predicting the very early coronary artery disease and cardiovascular outcomes.

Per Med 2018 Nov 26;15(6):521-529. Epub 2018 Oct 26.

State Key Laboratory of Cardiovascular Disease, Division of Dyslipidemia, Fu Wai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, BeiLiShi Road 167, Beijing 100037, China.

Aim: The link of oxidized-low-density lipoprotein (ox-LDL) with premature coronary artery disease (CAD) has previously been less examined. Materials & methods: A total of 1217 patients with angiography-proven CAD were consecutively enrolled and divided into very-early CAD (VECAD), early CAD and late CAD subgroups. And 72 normal control of VECAD were examined. Read More

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https://www.futuremedicine.com/doi/10.2217/pme-2018-0046
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http://dx.doi.org/10.2217/pme-2018-0046DOI Listing
November 2018
7 Reads

Interpretation of the noncoding genome in medicine.

Authors:
Julia di Iulio

Per Med 2018 Nov 22;15(6):453-455. Epub 2018 Oct 22.

The Scripps Research Institute, 3344 N Torrey Pines Rd, La Jolla, CA 92037, USA.

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https://www.futuremedicine.com/doi/10.2217/pme-2018-0065
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http://dx.doi.org/10.2217/pme-2018-0065DOI Listing
November 2018
5 Reads

Precision medicine in oncology: what is it exactly and where are we?

Per Med 2018 Sep 27;15(5):351-353. Epub 2018 Sep 27.

Pharmacogenomics Unit, Institute Curie, Paris, France.

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http://dx.doi.org/10.2217/pme-2018-0036DOI Listing
September 2018
21 Reads

Reconceptualizing harms and benefits in the genomic age.

Per Med 2018 Sep 27;15(5):419-428. Epub 2018 Sep 27.

National Institutes of Health, Clinical Center Department of Bioethics & National Human Genome Research Institute, Bethesda, MD, 20892, USA.

As new, high-powered sequencing technologies are increasingly incorporated into genomics research, we believe that there has been a break point in how risks and benefits associated with genetic information are being characterized and understood. Genomic sequencing provides the potential benefit of a wealth of information, but also has the potential to alter how we conceptualize risks of sequencing. Until now, our conceptions of risks and benefits have been generally static, arising out of the early ethical, legal and social implications studies conducted in the context of targeted genetics. Read More

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https://www.futuremedicine.com/doi/10.2217/pme-2018-0022
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http://dx.doi.org/10.2217/pme-2018-0022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295320PMC
September 2018
3 Reads

Personalized medicine and the future of dental practice.

Per Med 2018 Nov 27;15(6):449-451. Epub 2018 Sep 27.

Department of Periodontics & Oral Medicine, Division of Oral Medicine, Pathology & Radiology, University of Michigan School of Dentistry, 1011 North University Avenue, Rm G020A Ann Arbor, MI 48109, USA.

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http://dx.doi.org/10.2217/pme-2018-0055DOI Listing
November 2018
1 Read

Too much of a good thing? Overdiagnosis, or overestimating risk in preventive genomic screening.

Per Med 2018 Sep 27;15(5):343-346. Epub 2018 Sep 27.

Department of Genetics, The University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599-7264, USA.

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https://www.futuremedicine.com/doi/10.2217/pme-2018-0041
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http://dx.doi.org/10.2217/pme-2018-0041DOI Listing
September 2018
2 Reads

Polymorphism of PARP-1 indicates an increased risk and a worse initial severity of ischemic stroke.

Per Med 2018 Sep 27;15(5):355-360. Epub 2018 Sep 27.

Department of Rehabilitation Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, PR China.

Aim: Polymorphisms of DNA repair enzyme gene may alter the ability to repair damage and in turn may contribute to ischemic stroke susceptibility and outcome.

Methods: We selected 316 ischemic stroke patients and 302 healthy controls. Then we genotyped SNPs of PARP-1 rs3219119, rs2271347 and APE1 rs1130409 in patient and control groups. Read More

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http://dx.doi.org/10.2217/pme-2018-0007DOI Listing
September 2018
3 Reads

Wearables and the medical revolution.

Per Med 2018 Sep 27;15(5):429-448. Epub 2018 Sep 27.

Department of Genetics, Stanford University, Stanford, CA 94305, USA.

Wearable sensors are already impacting healthcare and medicine by enabling health monitoring outside of the clinic and prediction of health events. This paper reviews current and prospective wearable technologies and their progress toward clinical application. We describe technologies underlying common, commercially available wearable sensors and early-stage devices and outline research, when available, to support the use of these devices in healthcare. Read More

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https://www.futuremedicine.com/doi/10.2217/pme-2018-0044
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http://dx.doi.org/10.2217/pme-2018-0044DOI Listing
September 2018
16 Reads

Screening of TNF-α gene polymorphisms in patients with extremity chronic osteomyelitis in China.

Per Med 2018 Sep 27;15(5):395-401. Epub 2018 Sep 27.

Guangdong Provincial Key Laboratory of Bone & Cartilage Regenerative Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, PR China.

Aim: This study aims to investigate the link between TNF-α gene SNPs and patients with extremity chronic osteomyelitis in China.

Methodology: Our study included 433 subjects, composed of 233 extremity chronic osteomyelitis patients and 200 controls. Six single-nucleotide polymorphisms (rs1799964, rs1800630, rs1799724, rs1800750, rs1800629 and rs361525) in TNF-α gene were detected by the SNaPshot genotyping method. Read More

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http://dx.doi.org/10.2217/pme-2018-0017DOI Listing
September 2018
1 Read

Identifying novel candidate biomarkers of RCC based on WGCNA analysis.

Per Med 2018 Sep 27;15(5):381-394. Epub 2018 Sep 27.

College of Information Engineering, Shanghai Maritime University, 1550 Haigang Ave., Shanghai 201306, PR China.

Aim: Extracting differential expression genes (DEGs) is an effective approach to improve the accuracy of determining the candidate biomarker genes. However, the previous DEGs analysis methods ignore that the expression levels of genes in different pathology stages of cancers are complex and various.

Methods: In our study, staging DEGs analysis and weighted gene co-expression network analysis were applied to gene expression data of renal cell carcinoma (RCC). Read More

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http://dx.doi.org/10.2217/pme-2017-0091DOI Listing
September 2018
5 Reads

Correlation of vitamin D binding protein gene polymorphism and protein levels in chronic obstructive pulmonary disease compared with non-chronic obstructive pulmonary disease subjects.

Per Med 2018 Sep 27;15(5):371-379. Epub 2018 Sep 27.

Institute of Nutrition, Mahidol University, 999 Phutthamonthon 4 Rd., Salaya, Phutthamonthon, Nakhon Pathom 73170, Thailand.

Aim: The risk of vitamin D binding protein (DBP) variations in chronic obstructive pulmonary disease (COPD) compared with non-COPD Thai males were investigated.

Materials & Methods: The rs7041 and rs4588 polymorphisms of the DBP gene and protein level were measured in 136 COPD and 68 non-COPD Thai males.

Results: In the COPD group, GC1-1 gave increased forced expiratory volume at 1 s % predicted compared with GC1-2 but with no significant difference. Read More

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http://dx.doi.org/10.2217/pme-2018-0005DOI Listing
September 2018
2 Reads

Considering the downregulation of Tpm1.6 and Tpm1.7 in squamous cell carcinoma of esophagus as a potent biomarker.

Per Med 2018 Sep 27;15(5):361-370. Epub 2018 Sep 27.

Department of Medical Genetics, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.

Aim: Squamous cell carcinoma of esophagus (SCCE) is an aggressive disease with a poor prognosis. Tropomyosins attach to actin microfilaments, providing its stability. Nonmuscle cells express Tpm isoforms such as Tpm1. Read More

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http://dx.doi.org/10.2217/pme-2018-0015DOI Listing
September 2018
1 Read

Use of combinatorial pharmacogenomic guidance in treating psychiatric disorders.

Per Med 2018 Nov 26;15(6):481-494. Epub 2018 Sep 26.

Fairleigh Dickinson University, Madison, NJ 07666, USA.

Aim: To evaluate payer costs associated with treating psychiatric disorders utilizing a combinatorial pharmacogenomics test versus treatment-as-usual (TAU).

Patients & Methods: Administrative claims data were analyzed from health plan members whose treatment was guided by GeneSight Psychotropic testing (CPGx cohort) and those who received TAU (TAU cohort). Reimbursed costs were calculated over the 12-month pre-index and post-index event periods. Read More

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http://dx.doi.org/10.2217/pme-2018-0074DOI Listing
November 2018
7 Reads

Precision medicine in clinical practice.

Authors:
Deepak B Khatry

Per Med 2018 Sep 20;15(5):413-417. Epub 2018 Sep 20.

Statistical Sciences, Translational Sciences, MedImmune; One Medimmune Way, Gaithersburg, MD 20878, USA.

In reports of clinical efficacies of new therapies in prospective randomized controlled trials, evidence showing proportion of respondents who meet the minimum clinically important difference in prespecified clinical end points are often not presented. Such reporting deficiency negatively impacts precision medicine practice in clinics. As all patient-centric decisions are binary, patients must be understood as individuals and not group averages. Read More

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http://dx.doi.org/10.2217/pme-2018-0013DOI Listing
September 2018
1 Read

Enhancing diversity to reduce health information disparities and build an evidence base for genomic medicine.

Per Med 2018 Sep 13;15(5):403-412. Epub 2018 Sep 13.

UCSD Health Department of Biomedical Informatics, University of California San Diego, La Jolla, CA, 92093, USA.

Advances in genomic medicine are arising from efforts to build a national learning healthcare system (LHS) and large-scale precision medicine studies. However, the underlying evidence base lacks sufficient data from populations historically underrepresented in biomedical research. Although the literature on health and healthcare disparities is extensive, disparities in the availability and quality of health information about diverse and underrepresented populations are less well characterized. Read More

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http://dx.doi.org/10.2217/pme-2018-0037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287493PMC
September 2018
1 Read

Teaching students in clinical programs about pharmacogenomics: do they understand drug-drug interactions?

Per Med 2018 Sep 26;15(5):347-350. Epub 2018 Jul 26.

Associate Dean of ICPH Fairfax, Chair of Department of Pharmacogenomics & Professor, Shenandoah University, Bernard J. Dunn School of Pharmacy, D3323 - ICPH Fairfax, 3225 Gallows Rd, Fairfax, VA 22031, USA.

Teaching the clinical implementation of pharmacogenomics to students in clinical programs first requires careful consideration of their aptitude in basic clinical pharmacologic concepts. Prior to developing training exercises on drug-gene interactions, educators must first assess student competency in identifying and managing drug-drug interactions given the similarities in identifying and managing these sources of medication error. Read More

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http://dx.doi.org/10.2217/pme-2018-0028DOI Listing
September 2018
2 Reads

Zinc finger and interferon-stimulated genes play a vital role in TB-IRIS following HAART in AIDS.

Per Med 2018 07 9;15(4):251-269. Epub 2018 Jul 9.

Shenzhen Third People's Hospital, Shenzhen 518112, PR China.

Aim: Co-infection in HIV-1 patients with Mycobacterium tuberculosis poses considerable risk of developing the immune reconstitution inflammatory syndrome (IRIS), especially upon the initiation of antiretroviral therapy (ART). Methodology & results: For transcriptomic analysis, peripheral blood mononuclear cells' whole gene expression was used from three patient groups: HIV (H), HIV-TB (HT), HIV-TB with IRIS (HTI). Pathway enrichment and functional analysis was performed before and after highly active ART. Read More

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http://dx.doi.org/10.2217/pme-2017-0084DOI Listing
July 2018
5 Reads

miRNA 196a2(rs11614913) & 146a(rs2910164) polymorphisms & breast cancer risk for women in an Iranian population.

Per Med 2018 07 2;15(4):279-289. Epub 2018 Jul 2.

Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Aim: The purpose of our study was to analyze association of miRNAs 146aG/C(2910164) and 196a2C/T(11614913) polymorphism with breast cancer (BC) risk for women of Azeri ethnicity in Iran.

Materials & Methods: In the current case (n = 200)-control (n = 200) study, miRNAs 146aG/C(2910164) and 196a2C/T(11614913) were investigated for allelic and genotypic levels via the PCR-restriction fragment length polymorphism technique.

Results: The statistical analysis showed a significant relation between CC genotype of rs11614913(196a2) (codominant, odds ratio (OR) = 0. Read More

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http://dx.doi.org/10.2217/pme-2017-0088DOI Listing
July 2018
1 Read

Risk biomarkers enable precision in public health.

Per Med 2018 07 29;15(4):329-342. Epub 2018 Jun 29.

Center for Epidemiology, Division of Population Health, Faculty of Biology, Medicine & Health, The University of Manchester, Stopford Building, 99 Oxford Rd, Manchester, M13 9PG, UK.

Precision medicine uses biomarkers to diagnose disease. However, they can also be used to measure risk of disease. Thus, biomarkers herald a new addition to public health - Precision Public Health. Read More

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http://dx.doi.org/10.2217/pme-2017-0068DOI Listing
July 2018
3 Reads

Genomics-informed weight management in primary care: anticipated public interest.

Per Med 2018 07 22;15(4):271-278. Epub 2018 Jun 22.

Social & Behavioral Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.

Aim: An exploratory survey assessed the influence of current and potential future genomic applications for weight management on individuals' desires to address weight management within primary care. Materials & methods: A convenience sample of 714 US adults aged 18-70 completed an online survey that presented three scenarios: no genomic information; current genomic capabilities; and potential future applications of genomics for weight management.

Results: Participants had increased interest in weight management assistance through primary care when considering genomic applications in weight management, p (1,1. Read More

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http://dx.doi.org/10.2217/pme-2018-0011DOI Listing
July 2018
2 Reads

From false-positives to technological Darwinism: controversies in digital health.

Per Med 2018 07 22;15(4):247-250. Epub 2018 Jun 22.

Division of Cardiology, Emory University School of Medicine, Atlanta, GA, USA.

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http://dx.doi.org/10.2217/pme-2018-0033DOI Listing
July 2018
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The interference between oxaliplatin & anti-EGFR therapies: a different hypothesis to explain the 'unexplainable'.

Per Med 2018 07 21;15(4):319-327. Epub 2018 Jun 21.

Department of Medical Oncology, Fondazione Policlinico Universitario "A. Gemelli" - IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy.

This paper has been written because we have a differing idea concerning the suspected negative interference between oxaliplatin and anti-EGFR therapies in cancer patients. Several multicenter, randomized, controlled clinical trials investigated whether the efficacy of oxaliplatin-based chemotherapy is improved by the addition of anti-EGFR therapies in patients affected by KRAS wild-type advanced colorectal cancer. Results of these trials have produced puzzling findings, with some studies demonstrating improved survival and other studies showing no differences in overall survival between experimental and control arms. Read More

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http://dx.doi.org/10.2217/pme-2017-0082DOI Listing
July 2018
18 Reads

Horizon 2020 SME-Instrument topic: clinical research for the validation of biomarkers and/or diagnostic medical devices.

Authors:
Jean-Luc Sanne

Per Med 2018 07 21;15(4):303-309. Epub 2018 Jun 21.

Health Directorate, Directorate-General for Research & Innovation, European Commission, Brussels, Belgium.

The European Commission released €130 million over 2014, 2015 and 2017 under the EU Framework Program for Research and Innovation, Horizon 2020, to support innovative small and medium-sized enterprises in the diagnostic area. The call topic focused on 'Clinical research for the validation of biomarkers and/or diagnostic medical devices'. It attracted 1194 applicants from all over Europe. Read More

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http://dx.doi.org/10.2217/pme-2018-0003DOI Listing
July 2018
1 Read