208,573 results match your criteria Persistent Idiopathic Facial Pain


Intestinal parasites and lungworms in stray, shelter and privately owned cats of Switzerland.

Parasitol Int 2018 Dec 12. Epub 2018 Dec 12.

University of Zurich, Vetsuisse Faculty, Institute of Parasitology, Winterthurerstrasse 266a, 8057 Zurich, Switzerland. Electronic address:

Endoparasitic infections represent relevant causes of respiratory and gastrointestinal diseases in cats. The aim of the study was to investigate the occurrence of endoparasites in Swiss cats in order to evaluate the risk of onset of parasitic diseases and potential correlated zoonoses. Therefore 664 faecal samples from privately owned (n = 299), shelter (n = 197) and stray (n = 168) cats were investigated by sedimentation-flotation and 468 samples additionally by the Baermann technique. Read More

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December 2018

Is sonication of antibiotic-loaded cement spacers useful in two-stage revision of prosthetic joint infection?

J Microbiol Methods 2018 Dec 12. Epub 2018 Dec 12.

IRCSS Istituto Ortopedico Rizzoli, Bologna, Italy.

Background: In a two-stage exchange protocol for prosthetic joint infection (PJI), bacteria surviving over the antibiotic-loaded cement spacers may cause the persistence of infection with renewed clinical symptoms following the surgery. Culture after sonication of removed prosthesis is more sensitive than conventional periprosthetic tissue culture for the microbiological diagnosis of PJI. The aim of this study was to assess whether sonication of the spacer at the time of the second-stage procedure may improve the diagnosis of persistent PJI. Read More

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December 2018

Critical role of Ca3.2 T-type calcium channels in the peripheral neuropathy induced by bortezomib, a proteasome-inhibiting chemotherapeutic agent, in mice.

Toxicology 2018 Dec 12. Epub 2018 Dec 12.

Laboratory of Pharmacology and Pathophysiology, Faculty of Pharmacy, Kindai University (formerly known as Kinki University), Higashi-Osaka, 577-8802, Japan. Electronic address:

Bortezomib, a first-line agent for treatment of multiple myeloma, exhibits anticancer activity through proteasome inhibition. However, bortezomib-induced peripheral neuropathy (BIPN) is one of the most serious side effects. Since decreased proteasomal degradation of Ca3. Read More

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December 2018

Randomized Controlled Trial of Aquablation vs. Transurethral Resection of the Prostate in Benign Prostatic Hyperplasia: One-Year Outcomes.

Urology 2018 Dec 12. Epub 2018 Dec 12.

UT Southwestern Medical Center, Department of Urology, University of Texas Southwestern, Dallas, TX, US.

Objective: To report 1-year safety and efficacy outcomes after either Aquablation or TURP for the treatment of lower urinary tract symptoms related to BPH.

Methods: This double-blinded, multicenter prospective randomized controlled trial assigned 181 patients with BPH-related moderate-to-severe lower urinary tract symptoms to either electrocautery-based prostate resection (TURP) or Aquablation. Efficacy endpoints included reduction in International Prostate Symptom Score and improvement in uroflow parameters. Read More

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December 2018

Localization of Contextual and Context Removed Auditory Fear Memory within the Basolateral Amygdala Complex.

Neuroscience 2018 Dec 12. Epub 2018 Dec 12.

School of Psychology and Counselling, Queensland University of Technology, Brisbane, Australia; Institute of Health and Biomedical Innovation, Queensland University of Technology at Translational Research Institute, Brisbane, Australia; Center for the Study of Traumatic Stress, Department of Psychiatry, USU School of Medicine, Bethesda, MD, USA. Electronic address:

Debilitating and persistent fear memories can rapidly form in humans following exposure to traumatic events. Fear memories can also be generated and studied in animals via Pavlovian fear conditioning. The current study was designed to evaluate basolateral amygdala complex involvement following the formation of different fear memories (two contextual fear memories and one adjusted auditory fear memory). Read More

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December 2018

Ulnar Artery Occlusion and severity markers of vasculopathy in Systemic sclerosis: a multicenter cross-sectional study.

Arthritis Rheumatol 2018 Dec 15. Epub 2018 Dec 15.

Department of Internal Medicine and Clinical Immunology, CHU Rennes, Univ Rennes, France.

Objective: to evaluate the association of ulnar artery occlusion (UAO) assessed by Doppler Ultrasonography (dUS) with the severity markers of systemic sclerosis (SSc) METHODS: 204 unselected patients fulfilling 2013 ACR/EULAR classification criteria for SSc were included in this cross-sectional multicenter study. All patients benefit from bilateral hand dUS evaluating the presence of UAO and clinical/paraclinical visceral evaluation according to current guidelines. Univariable and multivariable ordinal regression models were conducted, grading the severity of UAO as "no UAO", "only one UAO" and "UAO on both hands" and assessing its association with clinical features of SSc. Read More

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December 2018
1 Read

Caring by Telecare? A Hermeneutic Study of Experiences among Older Adults and Their Family Caregivers.

J Clin Nurs 2018 Dec 15. Epub 2018 Dec 15.

Department of Health and Nursing Sciences, University of Agder, Norway.

Aims And Objectives: The purpose of this study was to obtain a deeper understanding of the persistent use of telecare for older adults and their family caregivers.

Background: Telecare is seen as part of the solution in home care services for ageing in place. Previous studies have shown that telecare is a complex intervention, and there is still a poor understanding of older adults' and their family caregivers' experience with the use of telecare. Read More

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December 2018

A Computerized Scoring System to Improve Assessment of Heparin-induced Thrombocytopenia Risk.

J Thromb Haemost 2018 Dec 14. Epub 2018 Dec 14.

University of Arizona College of Medicine - Phoenix, Division of Clinical Data Analytics and Decision Support, Phoenix, Arizona.

Background: Heparin induced thrombocytopenia (HIT) is an immune-mediated adverse drug event associated with life-threatening thrombotic complications. The four T's (4Ts) score is widely used to estimate the risk for HIT and guide diagnostic testing, but it is not easily amenable to computerized clinical decision support (CDS) implementation.

Objectives: Our main objective was to develop a HIT computerized risk (HIT-CR) scoring system that provides platelet count surveillance for timing and degree of thrombocytopenia to identify those for whom diagnostic testing should be considered. Read More

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December 2018

What Is Behind Cerebellar Vertigo and Dizziness?

Cerebellum 2018 Dec 14. Epub 2018 Dec 14.

Department of Neurology, Ludwig-Maximilians University, Marchioninistrasse 15, 81377, Munich, Germany.

The differential diagnosis of vertigo or dizziness as a result of cerebellar disorders can be difficult as many patients with a cerebellar pathology do not present with the full spectrum of cerebellar signs. The main goal of this study was to describe the typical clinical features of these patients with vertigo or dizziness of a cerebellar origin. We reviewed the medical records of 5400 patients with vertigo and dizziness from our tertiary outpatient clinic for vertigo and balance disorders. Read More

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December 2018

Ex vivo conditioning with IL-12 protects tumor-infiltrating CD8 T cells from negative regulation by local IFN-γ.

Cancer Immunol Immunother 2018 Dec 14. Epub 2018 Dec 14.

Department of Inflammation and Immunity, Cleveland Clinic, Lerner Research Institute, 9500 Euclid Avenue NE40, Cleveland, OH, 44195, USA.

Optimal ex vivo expansion protocols for adoptive cell therapy (ACT) must yield T cells able to effectively home to tumors and survive the inhospitable conditions of the tumor microenvironment (TME), while simultaneously exerting persistent anti-tumor effector functions. Our previous work has shown that ex vivo activation in the presence of IL-12 can induce optimal expansion of murine CD8 T cells, thus resulting in significant tumor regression after ACT mostly via sustained secretion of IFN-γ. In this report, we further elucidate the mechanism of this potency, showing that IL-12 additionally counteracts the negative regulatory effects of autocrine IFN-γ. Read More

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December 2018
2 Reads

Mitogen-activated protein kinases MPK3 and MPK6 are required for stem cell maintenance in the Arabidopsis shoot apical meristem.

Plant Cell Rep 2018 Dec 14. Epub 2018 Dec 14.

Department of Molecular Biology and Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, USA.

Key Message: CLV3p-mediated phosphorylation of MPK3 and MPK6 occurs via CLV1 and BAM1 receptors to regulate the maintenance of SAM development. The CLAVATA peptide-receptor (CLV3p-CLV1) pathway modulates a homeodomain master regulator WUSCHEL (WUS) transcription factor in the shoot apical meristem (SAM) with poorly defined signaling mechanisms. Here, we report that mitogen-activated protein kinases (MAPKs, also known as MPKs in plants) act in an intracellular signaling cascade to play an important role in the maintenance of SAM development. Read More

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December 2018

A novel role for E2F3b in regulating cocaine action in the prefrontal cortex.

Neuropsychopharmacology 2018 Dec 14. Epub 2018 Dec 14.

Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Drug abuse is a multifaceted disorder that involves maladaptive decision making. Long-lasting changes in the addicted brain are mediated by a complex circuit of brain reward regions. The prefrontal cortex (PFC) is one region in which chronic drug exposure changes expression and function of upstream transcriptional regulators to alter drug responses and aspects of the addicted phenotype. Read More

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December 2018

Survival and new-onset morbidity after critical care admission for acute pancreatitis in Scotland: a national electronic healthcare record linkage cohort study.

BMJ Open 2018 Dec 14;8(12):e023853. Epub 2018 Dec 14.

Surgery, School of Medicine, University of Edinburgh, Edinburgh, UK.

Introduction: Severe acute pancreatitis (AP) requiring critical care admission (ccAP) impacts negatively on long-term survival.

Objective: To document organ-specific new morbidity and identify risk factors associated with premature mortality after an episode of ccAP.

Design: Cohort study. Read More

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December 2018

Impact of Ga-PSMA-PET/CT on the radiotherapeutic approach for prostate cancer in comparison to CT - a retrospective analysis.

J Nucl Med 2018 Dec 14. Epub 2018 Dec 14.

Ludwig-Maximilians-University (LMU), Germany.

Gallium-prostate-specific membrane antigen positron emission tomography/computed tomography (Ga-PSMA PET/CT) offers unprecedented accuracy for staging of primary, persistent or recurrent prostate cancer. Thus, we hypothesized that PSMA PET/CT prior to radiotherapy significantly impacts the radiotherapeutic approach in comparison to the current standard of CT based approach. Between February 2014 and December 2017, a total of 172 patients received PSMA PET/CT before radiotherapy and were included in this retrospective analysis. Read More

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December 2018

A Notch-regulated proliferative stem cell zone in the developing spinal cord is an ancestral vertebrate trait.

Development 2018 Dec 14. Epub 2018 Dec 14.

Department of Zoology, University of Oxford, 11a Mansfield Road, Oxford, OX1 3SZ, UK

Vertebrates have evolved the most sophisticated nervous systems we know. These differ from the nervous systems of invertebrates in several ways, including the evolution of new cell types, and the emergence and elaboration of patterning mechanisms to organise cells in time and space. Vertebrates also generally have many more cells in their central nervous systems than invertebrates, and an increase in neural cell number may have contributed to the sophisticated anatomy of the brain and spinal cord. Read More

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December 2018

Low Level Insulin Content Within Abundant Non-Beta Islet Endocrine Cells in Long-Standing Type 1 Diabetes.

Diabetes 2018 Dec 14. Epub 2018 Dec 14.

McNair Medical Institute, Baylor College of Medicine, Houston, TX, 77030

Although most type 1 diabetes (T1D) patients continue to produce small amounts of insulin decades after disease onset, very few β-cells persist within their pancreata. Consequently, the source of persistent insulin secretion within T1D remains unclear. We hypothesized low-level insulin content within non-β-cells could underlie persistent T1D insulin secretion. Read More

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December 2018

Early onset children's interstitial lung diseases: Discrete entities or manifestations of pulmonary dysmaturity?

Paediatr Respir Rev 2018 Oct 9. Epub 2018 Oct 9.

Department of Histopathology, Royal Brompton & Harefield NHS Foundation Trust and National Heart and Lung Institute, Imperial College, London, UK.

Interstitial lung diseases in children (chILD) are rare and diverse. The current classifications include a group of early onset chILD specific to infancy, namely neuro-endocrine cell hyperplasia of infancy (NEHI), pulmonary interstitial glycogenosis (PIG) and the alveolar capillary-congenital acinar dysplasia (ACD-CAD) spectrum, as well as alveolar growth disorders. NEHI and PIG cells are seen in the normal developing foetal lung. Read More

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October 2018

Salmonella Persist in Activated Macrophages in T Cell-Sparse Granulomas but Are Contained by Surrounding CXCR3 Ligand-Positioned Th1 Cells.

Immunity 2018 Dec 4. Epub 2018 Dec 4.

Center for Immunology, Department of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, MN 55455, USA. Electronic address:

Salmonella enterica (Se) bacteria cause persistent intracellular infections while stimulating a robust interferon-γ-producing CD4 T (Th1) cell response. We addressed this paradox of concomitant infection and immunity by tracking fluorescent Se organisms in mice. Se bacteria persisted in nitric oxide synthase (iNOS)-producing resident and recruited macrophages while inducing genes related to protection from nitric oxide. Read More

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December 2018

Walking speed and spatiotemporal step mean measures are reliable during feedback-controlled treadmill walking; however, spatiotemporal step variability is not reliable.

J Biomech 2018 Dec 7. Epub 2018 Dec 7.

University of Nebraska - Omaha, Omaha, NE, United States. Electronic address:

The purpose of the study was to compare the effects of a feedback-controlled treadmill (FeedbackTM) to a traditional fixed-speed treadmill (FixedTM) on spatiotemporal gait means, variability, and dynamics. The study also examined inter-session reliability when using the FeedbackTM. Ten young adults walked on the FeedbackTM for a 5-minute familiarization followed by a 16-minute experimental trial. Read More

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December 2018

Prevalence of Salmonella in juvenile dogs affected with parvoviral enteritis.

J S Afr Vet Assoc 2018 Dec 5;89(0):e1-e6. Epub 2018 Dec 5.

Department of Companion Animal Clinical Studies, University of Pretoria.

Salmonellosis is a disease of major zoonotic importance and canine parvovirus is a potentially fatal cause of canine enteritis with a world-wide distribution. Persistent isolation of Salmonella during routine environmental sampling surveys of a hospital ward, reserved for the treatment of dogs with canine parvovirus infection, prompted investigation into a possible source. We hypothesised that dogs affected by canine parvovirus would have a higher prevalence of faecal salmonellae compared to an apparently healthy cohort. Read More

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December 2018
1 Read

Treatment of Wastewater Using Seaweed: A Review.

Int J Environ Res Public Health 2018 Dec 13;15(12). Epub 2018 Dec 13.

Sustainable Waste-To-Wealth, UTM-MPRC Institute for Oil & Gas, Resource Sustainability Research Alliance, Universiti Teknologi Malaysia, Johor Bahru, Johor 81310, Malaysia.

Inadequately treated or untreated wastewater greatly contribute to the release of unwanted toxic contaminants into water bodies. Some of these contaminants are persistent and bioaccumulative, becoming a great concern as they are released into the environment. Despite the abundance of wastewater treatment technologies, the adsorption method overall has proven to be an excellent way to treat wastewater from multiple industry sources. Read More

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December 2018
1 Read

Update on Insomnia after Mild Traumatic Brain Injury.

Brain Sci 2018 Dec 13;8(12). Epub 2018 Dec 13.

JFK Johnson Rehabilitation Institute, Edison, NJ 08820, USA.

Sleep disturbance after traumatic brain injury (TBI) has received growing interest in recent years, garnering many publications. Insomnia is highly prevalent within the mild traumatic brain injury (mTBI) population and is a subtle, frequently persistent complaint that often goes undiagnosed. For individuals with mTBI, problems with sleep can compromise the recovery process and impede social reintegration. Read More

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December 2018

Apigetrin treatment attenuates LPS-induced acute otitis media though suppressing inflammation and oxidative stress.

Biomed Pharmacother 2019 Jan 26;109:1978-1987. Epub 2018 Nov 26.

Clinical Laboratory, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450000, China.

The natural course of otitis media in children is acute and self-limiting. Nevertheless, about 10-20% children could experience recurrent or persistent otitis media. Thus, finding effective candidate to prevent acute otitis media is urgently required. Read More

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January 2019

Inhaled Epoprostenol for Pulmonary Hypertension Treatment in Neonates: A 12-Year Experience.

Am J Perinatol 2018 Dec 14. Epub 2018 Dec 14.

Division of Neonatology, Department of Paediatrics, CHU de Québec, Université Laval, Québec City, Québec, Canada.

Background:  Persistent pulmonary hypertension of the newborn (PPHN) occurs in 10% of neonatal respiratory insufficiency. To selectively reduce pulmonary vascular resistance, several treatments have been tried. Inhaled epoprostenol (iPGI) has been used for 12 years in our institution for the management of refractory PPHN despite the gaps in the literature to support this use. Read More

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December 2018
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Effects of a single transient transfection of Ten-eleven translocation 1 catalytic domain on hepatocellular carcinoma.

PLoS One 2018 14;13(12):e0207139. Epub 2018 Dec 14.

College of Pharmacy, Nanchang University, Nanchang, Jiangxi, P.R. China.

Tumor suppressor genes (TSGs), including Ten-eleven translocation 1 (TET1), are hypermethylated in hepatocellular carcinoma (HCC). TET1 catalytic domain (TET1-CD) induces genome-wide DNA demethylation to activate TSGs, but so far, anticancer effects of TET1-CD are unclear. Here we showed that after HCC cells were transiently transfected with TET1-CD, the methylation levels of TSGs, namely APC, p16, RASSF1A, SOCS1 and TET1, were distinctly reduced, and their mRNA levels were significantly increased and HCC cells proliferation, migration and invasion were suppressed, but the methylation and mRNA levels of oncogenes, namely C-myc, Bmi1, EMS1, Kpna2 and c-fos, were not significantly change. Read More

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December 2018

A tick beat in the electrocardiogram: Persistent third degree block as only manifestation of Lyme disease.

J Electrocardiol 2018 Dec 6;52:109-111. Epub 2018 Dec 6.

Internal Medicine Department, Hospital Universitario, Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, Mexico.

Lyme disease is the most common tick-borne illness in North America. A 23-year-old female presented to our emergency department with a chief complaint of sudden dyspnea and chest pain. An electrocardiogram revealed a third degree heart block. Read More

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December 2018

Toll-like receptor 3 activation increases voluntary alcohol intake in C57BL/6J male mice.

Brain Behav Immun 2018 Dec 11. Epub 2018 Dec 11.

Waggoner Center for Alcoholism and Addiction Research, University of Texas at Austin, Austin, TX 78712, USA; Institute for Neuroscience, University of Texas at Austin, Austin, TX 78712, USA.

Many genes differentially expressed in brain tissue from human alcoholics and animals that have consumed large amounts of alcohol are components of the innate immune toll-like receptor (TLR) pathway. TLRs initiate inflammatory responses via two branches: [1] MyD88-dependent or [2] TRIF-dependent. All TLRs signal through MyD88 except TLR3. Read More

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December 2018

Visibility Graph Analysis of Speech Evoked Auditory Brainstem Response in Persistent Developmental Stuttering.

Neurosci Lett 2018 Dec 11. Epub 2018 Dec 11.

The Ohio State University, United States. Electronic address:

In this research, the concept of fractality based on nonlinear science and chaos theory is explored to study and evaluate the complexity of speech-evoked auditory brainstem response (s-ABR) time series in order to capture its intrinsic multiscale dynamics. The visibility graph of the s-ABR series is proposed as a quantitative method to differentiate subjects with persistent developmental stuttering (PDS) from the normal group. Differential complexities between normal and PDS subjects is quantified using Graph index complexity (GIC). Read More

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December 2018

Vaginal dysbiosis, and the risk of human papillomavirus and cervical cancer: systematic review and meta-analysis.

Am J Obstet Gynecol 2018 Dec 11. Epub 2018 Dec 11.

Department of Obstetrics & Gynecology, Ghent University, Ghent, Belgium.

Objective: The vaginal microbiota proposedly influence the association between human papillomavirus and cervical cancer. Our aim was to assess if vaginal dysbiosis affects human papilloma virus acquistion, persistence, and progression to related cervical pre-malignancy.

Data Soruces: MEDLINE, Embase, CINAHL, Cochrane Library, and Web of Science (inception until June 2018). Read More

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December 2018
1 Read

Plecanatide for Treatment of Chronic Constipation and Irritable Bowel Syndrome.

Authors:
Bryan L Love

Am J Med 2018 Dec 11. Epub 2018 Dec 11.

University of South Carolina College of Pharmacy, Department of Clinical Pharmacy and Outcomes Sciences, Columbia, SC. Electronic address:

Chronic idiopathic constipation and irritable bowel syndrome with constipation are commonly encountered in ambulatory patients, but limited options exist for patients with persistent or severe symptoms following treatment with non-prescription products. Plecanatide (Trulance, Synergy Pharmaceuticals) is a 16-amino acid peptide analogue of uroguanylin that stimulates guanylate cyclase-C receptors to increase chloride and bicarbonate secretion into the intestine and prevents the absorption of sodium ions, thereby increasing the secretion of water into the lumen. The influx of additional fluid accelerates intestinal transit, softens the stool and facilitates easier defecation. Read More

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December 2018

Safety of endoscopy in cancer patients with thrombocytopenia and neutropenia.

Gastrointest Endosc 2018 Dec 11. Epub 2018 Dec 11.

The University of Texas MD Anderson Cancer Center, Department of Gastroenterology, Hepatology and Nutrition. Electronic address:

Background And Aims: Cancer patients are prone to thrombocytopenia and neutropenia, which increase the risk of bleeding and infection. We assessed the safety of endoscopic procedures in cancer patients with thrombocytopenia and/or neutropenia.

Methods: We studied consecutive cancer patients with thrombocytopenia and/or neutropenia who underwent endoscopic procedures from 2010 through 2015. Read More

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December 2018
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[Research progress of biologics in the treatment of chronic rhinosinusitis].

Authors:
Y Liu F Yuan

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Oct;32(19):1515-1518

Chronic rhinosinusitis (CRS) is an inflammatory disease of the nasal airways and paranasal sinuses. The condition is defined by more than 12 weeks of nasal obstruction, nasal discharge, facial pain/pressure, and reduced/lost smell. CRS is commonly further classified into 2 subsets based on its clinical phenotype: those with polyps (CRSwNP) and those without (CRSsNP). Read More

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October 2018

[Effects of budesonide aerosol inhalation on the immunological functions of peripheral dendritic cells in patients with allergic rhinitis].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Sep;32(18):1391-1395

Department of Otolaryngology Head and Neck Surgery, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, China.

To investigate the immunologic functional changes of peripheral dendritic cells (DC) in patients with allergic rhinitis (AR) during the treatment by budesonide aerosol inhalation.25 patients with moderate to severe persistent AR were concluded in current study, and they were given budesonide aerosol inhalation for 8 weeks. AR related nasal symptom scores and indices, peripheral DC counts and percentages as well as their activation before and 4 weeks, 8 weeks after treatment were determined. Read More

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September 2018

[The application of cineMRI in evaluation of upper airway obstruction levels in complicated pediatric OSAS].

Authors:
S He R D Zhang J Chen

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Dec;32(24):1886-1889

Department of Otolaryngology, Shanghai Children's Medical Center Affiliated with Shanghai Jiaotong University School of Medicine, Shanghai, 200127, China.

The aim of this study is to explore the role of cineMRI in the localization of upper airway obstruction in complicated pediatric OSAS. Eleven persistent OSAS and 11 complex OSAS patients underwent cineMRI. Each patient was imaged midline sagittal and axial magnetic resonance cine image. Read More

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December 2018

Hybrid ablation under intraoperative 3D voltage mapping guidance.

Multimed Man Cardiothorac Surg 2018 Dec 10;2018. Epub 2018 Dec 10.

Long-standing persistent atrial fibrillation remains a significant therapeutic challenge, often proving to be resistant to treatment with antiarrhythmic medications and transcatheter ablation. Hybrid ablation, which combines a minimally invasive surgical and transcatheter approach, is emerging as a promising treatment option. In this video tutorial, we demonstrate our method of hybrid ablation for long-standing persistent atrial fibrillation using advanced 3D electro-anatomical voltage mapping to guide the ablation process and thereby improve the ultimate effectiveness of the procedure. Read More

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December 2018

Acupuncture for Treatment of Persistent Disturbed Sleep: A Randomized Clinical Trial in Veterans With Mild Traumatic Brain Injury and Posttraumatic Stress Disorder.

J Clin Psychiatry 2018 Dec 11;80(1). Epub 2018 Dec 11.

Department of Neurology, Emory Sleep Center, Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia, USA.

Objective: To evaluate real, as compared with sham, acupuncture in improving persistent sleep disturbance in veterans with mild traumatic brain injury (mTBI) and posttraumatic stress disorder (PTSD).

Methods: This sham-controlled randomized clinical trial at a US Department of Veterans Affairs Medical Center (2010-2015) included 60 veterans aged 24-55 years (mean of 40 years) with history of mTBI of at least 3 months and refractory sleep disturbance. Most of these participants (66. Read More

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December 2018

A homozygous MITF mutation leads to familial Waardenburg syndrome type 4.

Am J Med Genet A 2018 Dec 14. Epub 2018 Dec 14.

Department of Otolaryngology - Head and Neck Surgery, The Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.

Waardenburg syndrome (WS) is a genetic disorder characterized by hearing loss and pigmentary abnormalities with variable penetrance. Though heterozygous mutations in MITF are a major cause for Waardenburg syndrome type 2 (WS2), homozygous mutations in this gene and the associated phenotype have been rarely characterized. In this study, we identified a novel p. Read More

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December 2018
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Factors associated with gastrostomy tube dependence following salvage total laryngectomy with microvascular free tissue transfer.

Head Neck 2018 Dec 14. Epub 2018 Dec 14.

Department of Otolaryngology - Head and Neck Surgery, Baylor College of Medicine, Houston, Texas.

Background: Following salvage total laryngectomy (STL) with microvascular-free tissue transfer (MFTT), patients are at high risk for swallowing dysfunction, but risk factors for persistent gastrostomy tube (G-tube) dependence are unknown.

Methods: Retrospective review of 33 patients who underwent STL with MFTT.

Results: A total oral diet was achieved by 81% of patients with ≥6 months of postoperative follow-up. Read More

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December 2018

Single-incision laparoscopy-assisted gastric transposition combined with thoracoscopic esophagectomy for esophageal replacement.

Asian J Endosc Surg 2018 Dec 13. Epub 2018 Dec 13.

Department of Pediatric Surgery, Ege University Faculty of Medicine, Izmir, Turkey.

Introduction: We present a novel approach to single-incision laparoscopy-assisted gastric transposition combined with thoracoscopic esophagectomy in a child with long-segment corrosive esophageal stricture (CES).

Materials And Surgical Technique: A 2.5-year-old boy with a history of caustic ingestion underwent periodic esophageal dilatations at 3-week intervals, four sessions of topical mitomycin C application, and a strict antacid/H antagonist therapy for 8 months. Read More

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December 2018

Clinical investigation of esophageal injury from cryoballoon ablation of persistent atrial fibrillation.

Pacing Clin Electrophysiol 2018 Dec 14. Epub 2018 Dec 14.

Heart center, Japan Red Cross Yokohama City Bay Hospital, Yokohama City, Japan.

Background: The cryoballoon (CB) can be utilized for extra pulmonary vein (PV) ablation such as for a left atrial (LA) posterior wall (LAPW) isolation. However, scrutiny of the esophageal injuries during the LAPW isolation has never been performed. We sought to thoroughly investigate the esophageal lesions (ELs) and gastric hypomotility (GH) caused by an LAPW isolation using a CB. Read More

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December 2018

Gender differences in symptoms and functional status in patients with atrial fibrillation undergoing catheter ablation.

Pacing Clin Electrophysiol 2018 Dec 13. Epub 2018 Dec 13.

Chapel Hill: Department of Medicine, Division of Cardiology, University of North Carolina, 160 Dental Circle CB#7075, Chapel Hill, NC 27599, USA.

Background: Catheter ablation improves symptoms and quality of life in patients with atrial fibrillation (AF); however, despite its benefit, women are less likely than men to undergo catheter ablation. Women with AF have been described to have more frequent and severe symptoms with a lower quality of life than men, and it is therefore unclear why women are less likely to undergo catheter ablation. We prospectively characterized gender differences in AF symptoms among men and women undergoing ablation at UNC using questionnaire data. Read More

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December 2018

Conduction recovery following pacemaker implantation after transcatheter aortic valve replacement.

Pacing Clin Electrophysiol 2018 Dec 13. Epub 2018 Dec 13.

Division of Cardiology, Bluhm Cardiovascular Institute, Feinberg School of Medicine, Northwestern University, Chicago, IL.

Background: Transcatheter aortic valve replacement (TAVR) is increasingly used to treat severe aortic stenosis. A frequent complication of TAVR is high grade or complete atrioventricular (AV) block requiring a permanent pacemaker (PPM). There is little data on the long-term dependency on pacing after TAVR. Read More

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December 2018

Fabrication of Kidney Proximal Tubule Grafts Using Biofunctionalized Electrospun Polymer Scaffolds.

Macromol Biosci 2018 Dec 13:e1800412. Epub 2018 Dec 13.

Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Universiteitsweg 99,, 3584, CG Utrecht, The Netherlands.

The increasing prevalence of end-stage renal disease and persistent shortage of donor organs call for alternative therapies for kidney patients. Dialysis remains an inferior treatment as clearance of large and protein-bound waste products depends on active tubular secretion. Biofabricated tissues could make a valuable contribution, but kidneys are highly intricate and multifunctional organs. Read More

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December 2018

Resolving reading disability-Childhood predictors and adult-age outcomes.

Dyslexia 2018 Dec 12. Epub 2018 Dec 12.

Niilo Mäki Institute, Jyväskylä, Finland.

We examined frequency of adult-age reading disability (RD) and its childhood predictors among 48 adults (20 to 39 years) with documented childhood RD, and contrasted their cognitive skills, education, and employment with 37 matched controls. Among individuals with childhood RD, more than half had improved in their reading fluency to the level where the set criterion for adult-age RD was not met anymore. More fluent rapid naming, less severe childhood RD, and multiple support providers in childhood together predicted improvement of reading fluency. Read More

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December 2018

Developmental exposure to psychostimulant primes activity-dependent gene induction in frontal cortex.

Dev Neurobiol 2018 Dec 12. Epub 2018 Dec 12.

Unit on Neural Circuits and Adaptive Behaviors, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, 20892, USA.

Perinatal neurodevelopment involves extensive formation of neural connections and onset of activity-dependent gene expression for synaptic function and plasticity. Exposure to psychostimulants at this stage imposes significant risks for developing cognitive and affective disorders later in life. However, how developmental exposure to psychostimulants may induce long lasting molecular changes relevant to neural circuit function remains incompletely understood. Read More

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December 2018

Prolongation of allograft survival by passenger donor regulatory T cells.

Am J Transplant 2018 Dec 12. Epub 2018 Dec 12.

Department of Surgery, University of Cambridge, School of Clinical Medicine, Cambridge, United Kingdom.

Tissue resident lymphocytes are present within many organs, and are presumably transferred at transplantation, but their impact upon host immunity is unclear. Here we examine whether transferred donor natural regulatory CD4 T cells (nT-regs) inhibit host alloimmunity and prolong allograft survival. Transfer of donor-strain lymphocytes was first assessed by identifying circulating donor-derived CD4 T cells in 21 consecutive human lung transplant recipients, with three patterns of chimerism apparent: transient; intermediate; and persistent (detectable for up to 6 weeks, 6 months, and beyond one year, respectively). Read More

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December 2018

Mutational profiles of persistent/recurrent laryngeal squamous cell carcinoma.

Head Neck 2018 Dec 12. Epub 2018 Dec 12.

Department of Otolaryngology - Head and Neck Surgery, University of Michigan Medical School, Ann Arbor, Michigan.

Background: We sought to describe targeted DNA sequencing data of persistent/recurrent laryngeal squamous cell carcinoma (LSCC) and to compare gene-specific alteration frequencies with that of primary, untreated LSCC specimens from The Cancer Genome Atlas (TCGA).

Methods: The tumors of 21 patients with persistent/recurrent LSCC were subjected to targeted DNA sequencing using the Ion AmpliSeq Comprehensive Cancer Panel. Gene-specific alteration frequencies were compared (Chi-Square test) to primary, untreated LSCC sequencing data from TCGA using the cBioPortal platform. Read More

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December 2018
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Environmental Conditions Affecting Re-release from Particulate Matter of 4-Nonylphenol into an Aqueous Medium.

Environ Toxicol Chem 2018 Dec 12. Epub 2018 Dec 12.

University of Redlands, 1200 E. Colton Ave., Redlands, CA 92373, USA.

4-Nonylphenol (4-NP) is a persistent organic pollutant with endocrine disrupting properties. This non-polar product of microbial degradation derived from the surfactant nonylphenol polyethoxylate (NPE), 4-NP is capable of long range transport attached to particulates. Bioactive concentrations of 4-NP have been found in the surface water, soils, snow and particulate matter of the Eastern Sierra Nevada Mountains (SNM), hundreds of miles from its origins. Read More

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December 2018

Covalent Vs Non-Covalent inhibition: Tackling Drug Resistance in EGFR - A Thorough Dynamic Perspective.

Chem Biodivers 2018 Dec 11. Epub 2018 Dec 11.

University of KwaZulu-Natal, Westville, School of Health Sciences, School of Health Sciences, University of, Not Available, 4001, Durban, SOUTH AFRICA.

A persistent challenge in the treatment of non-small cell lung cancer (NSCLC) with EGFR is the emergence of drug-resistant caused by somatic mutations. The EGFR L858R/T790M double mutant (EGFRDM) was found to be the most alarming variant. Despite the development of a wide range of inhibitors, none of them could inhibit EGFRDM effectively. Read More

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December 2018

Laparoscopic artificial urinary sphincter implantation in women with stress urinary incontinence: update on 13 years experience in a single center.

BJU Int 2018 Dec 11. Epub 2018 Dec 11.

Clinique du Pré, Dept of Urology, Technopôle Université, 13 Avenue René Laennec, 72018, Le Mans, France.

Introduction: Stress urinary incontinence (SUI) mainly affects women as a result of pregnancies with laborious delivery, obesity, and pelvic floor dysfunctions. The first therapeutic approach includes life-style interventions, pelvic floor muscle or bladder training. The second-line treatment usually is surgical. Read More

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December 2018