646 results match your criteria Pernio


Most chilblains observed during the COVID-19 outbreak occur in patients who are negative for COVID-19 on PCR and serology testing.

Br J Dermatol 2020 Jul 6. Epub 2020 Jul 6.

Dermatology Department, University Hospital Bordeaux, Bordeaux, France.

Introduction: Acral lesions, mainly chilblains, are the most frequently reported cutaneous lesions associated with COVID-19. In more than 80% of tested patients, nasopharyngeal swabs were negative on RT-PCR for SARS-CoV-2 when performed, and serology was generally not performed.

Materials And Methods: A national survey was launched on March 30, 2020 by the French society of dermatology asking physicians to report cases of skin manifestations in patients with suspected or confirmed COVID-19 by using a standardized questionnaire. Read More

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http://dx.doi.org/10.1111/bjd.19377DOI Listing

The spectrum of COVID-19-associated dermatologic manifestations: an international registry of 716 patients from 31 countries.

J Am Acad Dermatol 2020 Jul 2. Epub 2020 Jul 2.

Department of Dermatology, University of California San Francisco, San Francisco, CA.

Background: Coronavirus disease 2019 (COVID-19) has associated cutaneous manifestations.

Objective: To characterize the diversity of cutaneous manifestations of COVID-19, and facilitate understanding of underlying pathophysiology.

Methods: Case series from an international registry from the American Academy of Dermatology and International League of Dermatological Societies. Read More

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http://dx.doi.org/10.1016/j.jaad.2020.06.1016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7331510PMC

Coronavirus (COVID-19) Infection-Induced Chilblains: A Brisk Perieccrine Inflammatory Response.

Am J Dermatopathol 2020 Jun 30. Epub 2020 Jun 30.

American Dermatopathology Laboratory, Centerville, OH.

The varying cutaneous and pathological manifestations of coronavirus 2 (SARS-CoV-2 or COVID-19) may have prognostic implications. Acral ischemic findings present with a hypercoagulable state in critically ill COVID-19 patients. Pathologically confirmed varicella-like exanthem and perniosis COVID-19 cases have correlated with paucisymptomatic and asymptomatic patients in previous reports. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001733DOI Listing

Type I interferonopathies: cutaneous vasculopathy, chilblains, panniculitis-induced lipodystrophyand others skin manifestations.

G Ital Dermatol Venereol 2020 Jul 2. Epub 2020 Jul 2.

Autoinflammatory Diseases and Immunodeficiencies Center, Giannina Gaslini Institute, Genoa, Italy.

Type I interferonopathies are a clinically heterogeneous group of inherited disorders of the innate immune system characterized by constitutive activation of the type I interferon-signaling pathway. Cutaneous vasculopathy, lipodystrophy, interstitial lung disease and brain calcifications are the typical manifestations characterizing affected patients. The pathogenic mechanism commonly underlying these disorders is the abnormal activation of immune pathways involved in recognition of non-self-oligonucleotides. Read More

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http://dx.doi.org/10.23736/S0392-0488.20.06709-7DOI Listing

Concurrent chilblains and retinal vasculitis in a child with COVID-19.

J Eur Acad Dermatol Venereol 2020 Jul 2. Epub 2020 Jul 2.

Department of Dermatology, University Hospital La Paz, Madrid, Spain.

Reports on COVID-19 in children are limited. Despite new data emerging, and understanding of the disease improves rapidly, there are as yet several features and complications related to the disease that remain unknown. Herein, we report the first case of a child with chilblains and retinal vasculitis related to COVID-19. Read More

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http://dx.doi.org/10.1111/jdv.16801DOI Listing

Dermoscopy features of COVID-19-related chilblains in children and adolescents.

J Eur Acad Dermatol Venereol 2020 Jul 2. Epub 2020 Jul 2.

Department of Dermatology, Hospital Infantil Universitario Niño Jesús, Madrid, Spain.

Chilblains are skin condition frequently seen by physicians worldwide during the COVID-19 outbreak. We attended 22 children and adolescents with chilblains during the outbreak peak of COVID-19 in Madrid. The clinicopathologic and laboratory features of these patients have been reported. Read More

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http://dx.doi.org/10.1111/jdv.16800DOI Listing

COVID-19 and outbreak of chilblains: are they related?

J Eur Acad Dermatol Venereol 2020 Jun 27. Epub 2020 Jun 27.

Dermatology Department, Edouard Herriot Hospital, Hospices Civils de Lyon, Université Claude Bernard Lyon I, Lyon, France.

SARS-CoV-2 is a new coronavirus that causes COVID-19, a disease associated with severe pneumonia.1 Many other clinical manifestations have been associated with the disease (diarrhoea, anosmia, dysgeusia, etc.) and patients can be healthy carriers of the virus. Read More

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http://dx.doi.org/10.1111/jdv.16779DOI Listing

[Chilblains in lockdown: an old acquaintance in the context of COVID-19].

An Pediatr (Barc) 2020 Jun 11. Epub 2020 Jun 11.

Servicio de Dermatología, Hospital Universitario de Móstoles, Madrid, España.

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http://dx.doi.org/10.1016/j.anpedi.2020.06.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7287469PMC

Recent outbreak of chilblain-like lesions is not directly related with SARS-CoV-2 infection.

J Eur Acad Dermatol Venereol 2020 Jun 26. Epub 2020 Jun 26.

Department of Dermatology, CHU, Université Clermont Auvergne, 1 place Lucie et Raymond Aubrac, 63000, Clermont-Ferrand, France.

Throughout March and April 2020, dermatologists have observed an outbreak of chilblains despite climatic conditions not conducive to their apparition. These lesions have occurred simultaneously to the COVID-19 epidemic, suggesting a relationship between their onset and SARS-CoV-2 infection. Here we describe a series of 10 patients presenting chilblain-like lesions in whom we have searched for evidence of SARS-CoV-2 infection. Read More

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http://dx.doi.org/10.1111/jdv.16776DOI Listing

Cutaneous manifestations in SARS-CoV-2 infection (COVID-19): a French experience and a systematic review of the literature.

J Eur Acad Dermatol Venereol 2020 Jun 26. Epub 2020 Jun 26.

Department of Dermatology, Hôpital Cochin, AP-HP, Groupe Hospitalier Paris Centre Cochin-Hôtel Dieu-Broca, 89 rue d'Assas, 75006, Paris, France.

Skin manifestations have been increasingly reported in the setting of COVID-19. However, their incidence and presentation are debated, and the role, direct or undirect, of SARS-CoV-2 in their pathogenesis has yet to be determined. In this work, we aimed to analyze our experience in a French referral center and to perform a systematic review of the literature to evaluate the incidence and prognosis of cutaneous lesions observed in COVID-19 patients. Read More

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http://dx.doi.org/10.1111/jdv.16775DOI Listing

Evaluation of Chilblains as a Manifestation of the COVID-19 Pandemic.

JAMA Dermatol 2020 Jun 25. Epub 2020 Jun 25.

Department of Dermatology, Cliniques universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium.

Importance: During the coronavirus disease 2019 (COVID-19) pandemic, several cases of chilblains have been reported.

Objective: To determine if chilblains are associated with COVID-19.

Design, Setting, And Participants: This monocentric case series was conducted at the Department of Dermatology at Cliniques universitaires Saint-Luc, a tertiary care hospital in Brussels, Belgium, between April 10 and April 17, 2020. Read More

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http://dx.doi.org/10.1001/jamadermatol.2020.2368DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317655PMC

COVID-19-associated Hemophagocytic Lymphohistiocytosis and Coagulopathy: Targeting the Duumvirate.

Indian Pediatr 2020 Jun 24. Epub 2020 Jun 24.

Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Context: Preliminary data on coexistence of secondary hemophagocytic lymphohistiocytosis syndrome (HLH) and disseminated intravascular coagulation (DIC) in critically ill children with novel coronavirus disease (COVID-19) are emerging. Herein, we summarize the available literature and fill-in the gaps in this regard.

Evidence Acquisition: We have performed a literature search for articles in PubMed, EMBASE and Google Scholar databases till May 12, 2020, with following keywords: "COVID-19", "SARS-CoV-2", "HLH", "HScore", "coagulopathy", "D-dimer", "cytokine storm", "children" and "pediatrics" with interposition of Boolean operator "AND". Read More

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Cutaneous manifestations in hospitalized patients diagnosed as COVID-19.

Dermatol Ther 2020 Jun 24. Epub 2020 Jun 24.

Istanbul University-Cerrahpasa, CerrahpaŞa Medical Faculty, Deparment of Dermatology and Venerology, Istanbul, Turkey.

Background: Cutaneous manifestations of COVID-19 disease have not yet been fully described.

Objectives: To describe cutaneous manifestations of COVID-19 disease in hospitalized patients.

Methods: We examined the cutaneous manifestations of 210 hospitalized patients. Read More

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http://dx.doi.org/10.1111/dth.13896DOI Listing

Histopathological Study of a Broad Spectrum of Skin Dermatoses in Patients Affected or Highly Suspected of Infection by COVID-19 in the Northern Part of Italy: Analysis of the Many Faces of the Viral-Induced Skin Diseases in Previous and New Reported Cases.

Am J Dermatopathol 2020 Jun 10. Epub 2020 Jun 10.

Division of Pathology, Università degli Studi di Milano, Foundation IRCCS, Cà Granda Ospedale Maggiore Policlinico, Milan, Italy.

Skin manifestations of COVID-19 infections are diverse and are new to the dermatology community. We had the opportunity to examine the clinical and histopathological features of several patients who were divided into 3 groups. The first group included 8 COVID-19-positive patients who were hospitalized and quarantined at home. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001707DOI Listing

Understanding the role that 'COVID toe' has in recognizing the potential extent of COVID-19 infections: a case study.

Pathog Glob Health 2020 Jun 24:1-2. Epub 2020 Jun 24.

GKT School of Medical Education, King's College London , London, UK.

Dermatological manifestations have shown to be associated with COVID-19 infections. The numbers of papers have quadrupled within May 2020 alone. One particular cutaneous manifestation named pseudo chilblains (COVID toe), expressed mostly in otherwise asymptomatic younger patients, has had particular media attention. Read More

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http://dx.doi.org/10.1080/20477724.2020.1785200DOI Listing

Chilblains and COVID19 infection: Causality or coincidence? How to proceed?

J Med Vasc 2020 Jul 11;45(4):221-223. Epub 2020 May 11.

Department of Dermatology, Nantes University Hospital, 44000 Nantes, France.

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http://dx.doi.org/10.1016/j.jdmv.2020.05.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7211700PMC

When interferon tiptoes through COVID-19: Pernio-like lesions and their prognostic implications during SARS-CoV-2 infection.

J Am Acad Dermatol 2020 Jun 18. Epub 2020 Jun 18.

Department of Dermatology, Yale School of Medicine, 333 Cedar St, LCI 501, PO Box 208059, New Haven, Connecticut, USA, 06510. Electronic address:

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http://dx.doi.org/10.1016/j.jaad.2020.06.052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7303035PMC

SARS-CoV-2 endothelial infection causes COVID-19 chilblains: histopathological, immunohistochemical and ultraestructural study of 7 paediatric cases.

Br J Dermatol 2020 Jun 20. Epub 2020 Jun 20.

Department of Dermatology, Hospital Infantil Universitario Niño Jesús, Madrid, Spain.

Background: Chilblains ("COVID toes") are being seen with increasing frequency in children and young adults during the COVID-19 pandemic. Detailed histopathological descriptions of COVID-19 chilblains have not been reported, and causality of SARS-CoV-2 has not been established yet.

Objective: To describe histopathological features of Covid-19 chilblains and explore the presence of SARS-CoV-2 in the tissue. Read More

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http://dx.doi.org/10.1111/bjd.19327DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7323219PMC

Outbreak of chilblain-like acral lesions in children in the metropolitan area of Milan, Italy, during the COVID-19 pandemic.

J Am Acad Dermatol 2020 Jun 10. Epub 2020 Jun 10.

Dermatology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy;; Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Milan, Italy.

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http://dx.doi.org/10.1016/j.jaad.2020.06.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7286233PMC

Major cluster of paediatric 'true' primary chilblains during the COVID-19 pandemic: a consequence of lifestyle changes due to lockdown.

J Eur Acad Dermatol Venereol 2020 Jun 13. Epub 2020 Jun 13.

Pediatric Emergency Unit, Department of Medical and Surgical Sciences (DIMEC), St. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy.

Background: Over the last months, during the COVID-19 pandemic, a growing number of chilblain-like lesions were reported mainly in children and rarely in young adults. The relationship with SARS-CoV-2 infection was postulated, often without any laboratory, instrumental or clinical confirmation. The disclosure of information about chilblain-like lesions as a COVID-19 manifestation in social media has created concern in children's families and paediatricians. Read More

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http://dx.doi.org/10.1111/jdv.16751DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7323208PMC

Chilblains in children in the time of Covid-19: new evidence with serology assay.

Pediatr Dermatol 2020 Jun 13. Epub 2020 Jun 13.

Pediatric Dermatology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.

In a previous report in Pediatric Dermatology, we described chilblains-like lesions in four pediatric patients. From April 18 to May 10, 2020, 45 children presented to our Pediatric Dermatology department with similar acral lesions. The clinical appearance ranged from red to violaceous macules and dusky, purpuric plaques on the heels, soles and lateral margin of the feet, often accompanied by painful edema, consistent with chilblains. Read More

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http://dx.doi.org/10.1111/pde.14269DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7323211PMC

Rash as a presenting complaint in a child with COVID-19.

Pediatr Dermatol 2020 Jun 11. Epub 2020 Jun 11.

Children's Emergency Assessment Unit, Noah's Ark Children's Hospital for Wales, Cardiff, United Kingdom.

Cutaneous manifestations are becoming increasingly well-documented in adults with COVID-19. There is now also a growing body of literature regarding skin involvement in children, with reports of papulovesicular, petechial and widespread macular and papular lesions, as well as chilblains (pernio). We describe the case of a thirteen-year-old boy with confirmed COVID-19 in the United Kingdom who presented with skin findings localized to the plantar aspects of the feet, axillae and lower limbs. Read More

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http://dx.doi.org/10.1111/pde.14257DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7307022PMC

A Chinese case of Nakajo-Nishimura syndrome with novel compound heterozygous mutations of the PSMB8 gene.

BMC Med Genet 2020 Jun 8;21(1):126. Epub 2020 Jun 8.

Department of Dermatology, Northwest Hospital, The Second Hospital Affiliated to Xi'an Jiaotong University, Xi'an, China.

Background: Nakajo-Nishimura syndrome (NNS) is an autosomal recessive heredity disorder, one of a spectrum of autoinflammatory diseases named proteasome-associated autoinflammatory syndrome (PRAAS) caused by mutations of PSMB8 gene. NNS is characterized by pernio-like skin rashes, intermittent fever, and long clubbed fingers and toes with joint contractures, partially with progressive lipomuscular atrophy, emaciation, hepatosplenomegaly and basal ganglion calcification.

Case Presentation: We presented a sporadic case of NNS with compound heterozygous mutations in the PSMB8 gene. Read More

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http://dx.doi.org/10.1186/s12881-020-01060-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7278201PMC

CHILBLAIN-LIKE ACRAL LESIONS DURING THE COVID-19 PANDEMIC ("COVID TOES"): HISTOLOGIC, IMMUNOFLUORESCENCE AND IMMUNOHISTOCHEMICAL STUDY OF 17 CASES.

J Am Acad Dermatol 2020 Jun 2. Epub 2020 Jun 2.

Department of Dermatology, Edouard Herriot Hospital, Hospices Civils de Lyon, Lyon.

Background: During the COVID-19 pandemic, several acral chilblain-like skin lesions (CBLL) were observed in young patients with suspected, but mostly unconfirmed, infection with SARS-CoV-2. The histopathological aspect of these lesions is as yet poorly known.

Objective: To investigate the pathologic features of CBLL. Read More

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http://dx.doi.org/10.1016/j.jaad.2020.05.145DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7265862PMC

Reply to: "Characterization of acute acro-ischemic lesions in non-hospitalized patients: a case series of 132 patients during the COVID-19 outbreak".

J Am Acad Dermatol 2020 Jun 1. Epub 2020 Jun 1.

Pediatric Gastroenterology and Liver Unit, Maternal and Child Health Department, Sapienza - University of Rome, Rome, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.jaad.2020.05.122DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7262530PMC

Effect of Calcium-Channel Blockade on the Cold-Induced Vasodilation Response.

Wilderness Environ Med 2020 May 29. Epub 2020 May 29.

University of Utah, Division of Emergency Medicine, Salt Lake City, UT.

Introduction: Cold-induced vasodilation (CIVD) is seen in the extremities during exposure to cold. A strong vasodilation response has been associated with a decreased risk of cold injury. Increasing CIVD might further decrease this risk. Read More

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http://dx.doi.org/10.1016/j.wem.2020.03.002DOI Listing

Pernio-like skin lesions associated with COVID-19: a case series of 318 patients from 8 countries.

J Am Acad Dermatol 2020 May 29. Epub 2020 May 29.

Department of Dermatology, University of California San Francisco, San Francisco, CA.

Background: Increasing evidence suggests pernio-like lesions are cutaneous manifestations of COVID-19.

Objective: To describe clinical and pathologic findings of pernio-like lesions in confirmed or suspected COVID-19 cases.

Methods: An international dermatology registry was circulated to healthcare providers worldwide through the American Academy of Dermatology (AAD), International League of Dermatologic Societies (ILDS), and other organizations. Read More

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http://dx.doi.org/10.1016/j.jaad.2020.05.109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260509PMC

Further evidence that chilblains are a cutaneous manifestation of COVID-19 infection.

Br J Dermatol 2020 May 27. Epub 2020 May 27.

Department of Experimental and Clinical Medicine, University of Florence and Department of Geriatric Medicine, Division of Rheumatology AOUC, Florence, Italy.

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http://dx.doi.org/10.1111/bjd.19243DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7283762PMC

Acral findings during the COVID-19 outbreak: Chilblain-like lesions should be preferred to acro-ischemic lesions.

J Am Acad Dermatol 2020 May 21. Epub 2020 May 21.

UO Dermatologia Lucca- Azienda USL Toscana Nordovest, Italy; Department of Health Science, University of Florence, Florence, Italy.

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http://dx.doi.org/10.1016/j.jaad.2020.05.077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7242179PMC

Erythema multiforme-like lesions in children and COVID-19.

Pediatr Dermatol 2020 May;37(3):442-446

Department of Pathology, Hospital Infantil Universitario Niño Jesús, Madrid, Spain.

During examination of cases of chilblains in children and adolescents, we identified four patients who also showed skin lesions similar to erythema multiforme (EM). They had no other known triggers for EM. One of them had a positive PCR for SARS-CoV-2, while the other three were negative. Read More

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http://dx.doi.org/10.1111/pde.14246DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7283638PMC

[Chilblains in lockdown: An old acquaintance in the context of COVID-19].

An Pediatr (Barc) 2020 Jun 25;92(6):387-388. Epub 2020 Apr 25.

Servicio de Dermatología, Hospital Universitario y Politécnico La Fe, Valencia, España. Electronic address:

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http://dx.doi.org/10.1016/j.anpedi.2020.04.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7183286PMC

Chilblains in children in the setting of COVID-19 pandemic.

Pediatr Dermatol 2020 May 22;37(3):406-411. Epub 2020 May 22.

Department of Dermatology, Hospital Infantil Universitario Niño Jesús, Madrid, Spain.

Background: Different skin manifestations of COVID-19 are being reported. Acral lesions on the hands and feet, closely resembling chilblains, have been recognized during the peak incidence of the COVID-19 pandemic.

Material And Methods: A retrospective review of 22 children and adolescents with chilblain-like lesions seen over a short period of time in the Emergency Department of a children's hospital during the peak incidence of COVID-19 in Madrid, Spain. Read More

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http://dx.doi.org/10.1111/pde.14215DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7272985PMC

Re: Chilblain-like lesions on feet and hands during the COVID-19 pandemic.

Authors:
Rokea El-Azhary

Int J Dermatol 2020 06 8;59(6):748. Epub 2020 May 8.

Mayo Clinic, 200 First Street, SW, Rochester, MN, 55905, USA.

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http://dx.doi.org/10.1111/ijd.14956DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7267426PMC

Chilblains is a common cutaneous finding during the COVID-19 pandemic: A retrospective nationwide study from France.

J Am Acad Dermatol 2020 May 4. Epub 2020 May 4.

Department of Dermatology, Mondor Hospital, Assistance Publique-Hôpitaux de Paris, Chaire Avenir Santé numérique, Equipe 8 Institut Mondor de Recherche Biomédicale, Human Immunology, Pathophysiology and Immunotherapy, Université Paris Est Créteil, Créteil, France.

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http://dx.doi.org/10.1016/j.jaad.2020.04.161DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7198162PMC

Chilblain-like lesions in pediatrics dermatological outpatients during the COVID-19 outbreak.

Dermatol Ther 2020 May 6:e13516. Epub 2020 May 6.

Servicio de Dermatología, Hospital Universitario San Cecilio, Instituto Biosanitario Ibs de Granada, Granada, Spain.

In Spain, with full confinement measures and coinciding with the pandemic, pediatricians and dermatologists have received, through teledermatology/teleconsultation and social networks, a barrage of diverse images, which have subsequently allowed us to approach some of them by direct physical examination of early and late skin manifestations associated with SARS-Cov-2 infection. We designed a retrospective, cross-sectional study to evaluate the dermatological care of all those patients under the age of 16 who consulted, in person or telematically, for acral lesions (chilblain-like or erythema multiforme-like) in the context of the Coronavirus disease (COVID-19) pandemic, since 15 March 2020 to 24 April 2020, both included in the health area of the Hospital Universitario San Cecilio de Granada. Of all the patients collected, 18 (66%) were male and the overall mean age was 14. Read More

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http://dx.doi.org/10.1111/dth.13516DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7261972PMC

Two cases of COVID-19 presenting with a clinical picture resembling chilblains: first report from the Middle East.

Clin Exp Dermatol 2020 Apr 17. Epub 2020 Apr 17.

Department of Dermatology, Quttainah Medical Centre, Kuwait City, Kuwait.

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http://dx.doi.org/10.1111/ced.14243DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7264553PMC

Diagnosis of Aicardi-Goutières Syndrome in Adults: A Case Series.

Mov Disord Clin Pract 2020 Apr 17;7(3):303-307. Epub 2020 Feb 17.

Neurology Department Centro Hospitalar Universitário do Porto Porto Portugal.

Introduction: Aicardi-Goutières syndrome (AGS) is a genetic disease presenting with early-onset encephalopathy, generalized dystonia, spasticity, and cognitive disability. Diagnosis may be difficult in adults, as the clinical course seems static from infancy.

Methods: AGS patients from an adult movement disorders outpatient clinic were retrospectively analyzed. Read More

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http://dx.doi.org/10.1002/mdc3.12903DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7111574PMC

A case of chronic sarcoidosis presenting with lupus pernio.

Postgrad Med 2020 Feb 27:1-4. Epub 2020 Feb 27.

Adana City Education and Training Hospital, Chest Disease.

Sarcoidosis is a systemic granulomatous disease of unknown cause. Skin involvement may be specific lesions in which granulomas are detected on biopsy or nonspecific lesions without granulomatous inflammation on biopsy. Lupus pernio (LP) occurs in the form of smooth, bright nodules and plaques on the nose, ear, lips, and cheeks. Read More

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http://dx.doi.org/10.1080/00325481.2020.1733863DOI Listing
February 2020

Pernio-Induced Toe Pain in the Setting of Onychocryptosis: A Case Report.

J Am Podiatr Med Assoc 2020 Jan;110(1):Article7

Pernio is an inflammatory condition of the skin associated with cold exposure. The dermatologic manifestations may vary, and this entity is frequently misdiagnosed. Its association with systemic disease underscores the importance of accurate diagnosis. Read More

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http://dx.doi.org/10.7547/18-018DOI Listing
January 2020

Tolio: Foot Rot in Grand Canyon River Runners.

Wilderness Environ Med 2020 Mar 31;31(1):82-86. Epub 2020 Jan 31.

Retired.

Treating skin disorders in wilderness settings is often challenging. In this report we describe common skin conditions affecting the feet of river runners on the Colorado River in Grand Canyon National Park. These conditions are frequently referred to by river runners with a catchall term, "tolio. Read More

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http://dx.doi.org/10.1016/j.wem.2019.09.003DOI Listing

A Pediatric Case of Gingival Swelling and Chilblains as Previously Unrecognized Manifestations of Chronic Nonbacterial Osteomyelitis.

J Clin Rheumatol 2020 Jan 15. Epub 2020 Jan 15.

From the Department of Pediatrics, School of Medicine, University of Occupational and Environmental Health.

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http://dx.doi.org/10.1097/RHU.0000000000001270DOI Listing
January 2020

Chilblains.

Vasa 2020 Mar 6;49(2):133-140. Epub 2019 Dec 6.

Department of Vascular Diseases, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium.

Idiopathic chilblain is a relatively common yet poorly recognized acrosyndrome. This literature review aims to better understand and draw attention to this disorder. Chilblain is a localized inflammation of the skin that occurs on exposure to cold but non-freezing wet weather. Read More

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http://dx.doi.org/10.1024/0301-1526/a000838DOI Listing

Hypothermia and Cold Weather Injuries.

Am Fam Physician 2019 12;100(11):680-686

Evans Army Community Hospital, Fort Carson, CO, USA.

Hypothermia, frostbite, and nonfreezing cold injuries predominantly affect older adults, homeless or intoxicated people, adventurers, and military personnel. Prevention begins with clothing that is clean, layered, and loose to promote circulation. Base layers made of moisture-wicking materials are favored over wool or cotton. Read More

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December 2019