835 results match your criteria Pernio


Relapse of chilblain-like lesions during the second COVID-19 pandemic wave: a cohort follow-up.

Br J Dermatol 2021 Jun 15. Epub 2021 Jun 15.

Côte d'Azur University. CHU Nice, Department of Dermatology. Nice, France.

Chilblain-like lesions have been reported during the COVID-19 pandemic. Studies based on serology and rt-PCR exploring the causal link between chilblains and COVID-19 infection reported conflicting results . However, a significant proportion of patients who developed chilblains reported they had contact with COVID-19 suspected cases . Read More

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Covid-19 skin manifestations: an update.

Curr Opin Pediatr 2021 Jun 14. Epub 2021 Jun 14.

Boston Children's Hospital, Dermatology Program Harvard Medical School, Boston, Massachusetts, USA.

Purpose Of Review: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) or COVID-19 is a multisystemic disease manifesting mainly with dry cough, fever, and pneumonia and can present with a myriad of cutaneous manifestations. This chapter will review SARS-CoV-2 associated cutaneous findings, including incidence and relevance to the pediatric population.

Recent Findings: The most commonly reported cutaneous findings described for COVID-19 in adults and children were chilblains-like lesions, followed by maculopapular eruption, urticarial lesions, vesicular lesions, and livedoid lesions. Read More

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A Review of COVID-19 Chilblains-like Lesions and Their Differential Diagnoses.

Adv Skin Wound Care 2021 Jul;34(7):348-354

General Purpose: To familiarize wound care practitioners with the differential diagnoses of chilblains-like lesions that could be associated with the complications of COVID-19.

Target Audience: This continuing education activity is intended for physicians, physician assistants, nurse practitioners, and nurses with an interest in skin and wound care.

Learning Objectives/outcomes: After participating in this educational activity, the participant will:1. Read More

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Unilateral chilblains affecting the lower limb with post-polio residual paralysis: An example of immunocompromised cutaneous district.

Indian J Dermatol Venereol Leprol 2021 May 8:1-2. Epub 2021 May 8.

Department of Dermatology and Venereology All India Institute of Medical Sciences, New Delhi, India.

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Chilblains-like Nonischemic Eruption During the COVID-19 Pandemic-Distinct Features in Adolescents.

Authors:
Farzam Gorouhi

JAMA Netw Open 2021 06 1;4(6):e2111676. Epub 2021 Jun 1.

Department of Dermatology, University of California, Davis.

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Generalised lymphadenopathy in a patient with fever of unknown origin as a differential diagnostic challenge - case report.

J Pak Med Assoc 2021 May;71(5):1489-1492

Department of Infectious diseases, Faculty of Medical Sciences, University of Kragujevac, Serbia.

Fever of unknown origin (FUO) presents a major diagnostic challenge as it is a consequence of many infectious as well as malignant, rheumatologic and other diseases. Here we present the case of a woman with mediastinal and abdominal lymphadenopathy who was initially suspected to have lymphoproliferative disease, but our histopathologic examination revealed sarcoidosis. Sarcoidosis, especially chronic, is a rare cause of FUO, because it usually manifests as a febrile condition. Read More

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Clinical Manifestations of COVID-19 in the Feet: A Review of Reviews.

J Clin Med 2021 May 19;10(10). Epub 2021 May 19.

Department of Podiatry, Faculty of Nursing, Physiotherapy and Podiatry, University of Sevilla, 41009 Sevilla, Spain.

There is a lack of scientific evidence about the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The clinical manifestations are not thoroughly understood; classically, the virus manifests itself at the pulmonary level but can manifest at other levels. To the best of our knowledge, systematic reviews and non-systematic reviews about COVID-19 symptoms in the feet have not been published. Read More

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Kaempferol-3-O-Glucuronide Ameliorates Non-Alcoholic Steatohepatitis in High-Cholesterol-Diet-Induced Larval Zebrafish and HepG2 Cell Models via Regulating Oxidation Stress.

Life (Basel) 2021 May 14;11(5). Epub 2021 May 14.

School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, China.

NAFLD (non-alcoholic fatty liver disease) is one of the most prominent liver diseases in the world. As a metabolic-related disease, the development of NAFLD is closely associated with various degrees of lipid accumulation, oxidation, inflammation, and fibrosis. Ilex chinensis Sims is a form of traditional Chinese medicine which is used to treat bronchitis, burns, pneumonia, ulceration, and chilblains. Read More

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Clinical features of tumor necrosis factor-α-inhibitor induced chilblain lupus: A case series.

JAAD Case Rep 2021 Jun 24;12:81-84. Epub 2021 Apr 24.

Department of Dermatology, University of Wisconsin Hospital and Clinics, Madison, Wisconsin.

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Cutaneous manifestations associated with COVID-19 in children: A systematic review.

J Family Med Prim Care 2021 Jan 30;10(1):93-101. Epub 2021 Jan 30.

Professor, Department of Pediatrics, All India Institute of Medical Sciences, Raipur, Chhattisgarh, India.

Cutaneous manifestation of COVID 19 in children has not yet been reviewed systematically. Hence, this review gives the clinicians a future direction to be vigilant for skin presentations during pandemics. The Pubmed database used for literature search with keywords COVID 19, children, and skin in different combinations. Read More

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January 2021

Chilblains?

Authors:

J Clin Rheumatol 2021 Jun;27(4):172

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Skin lesions in children during the first wave of the SARS-CoV-2 pandemic.

Med Clin (Barc) 2021 May 4. Epub 2021 May 4.

Unidad de Reumatología Pediátrica, UGC Pediatría, Hospital Regional Universitario de Málaga, Málaga, España.

Background: Cutaneous manifestations have been included in COVID-19 patients' clinical spectrum. Our objective was to determine the association between skin lesions in children and SARS-CoV-2 infection, analyzing others possible infectious/autoimmune etiologies.

Material And Methods: Observational, multicenter, cross-sectional study, about children with skin manifestations from April to May 2020. Read More

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Not all that glitters is COVID-19: a case series demonstrating the need for histopathology when skin findings accompany SARS-CoV-2 infection.

J Eur Acad Dermatol Venereol 2021 May 20. Epub 2021 May 20.

Department of Dermatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.

Background: Descriptions of cutaneous findings associated with COVID-19 have not been consistently accompanied by histopathology or confirmatory testing for SARS-CoV-2.

Objective: To describe and classify the cutaneous findings with supporting histopathology of confirmed COVID-19 inpatients.

Methods: We included consecutive inpatients with a confirmed diagnosis of COVID-19 for whom a dermatology consult was requested. Read More

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Pediatric COVID toes and fingers.

Clin Dermatol 2021 Jan-Feb;39(1):84-91. Epub 2021 Jan 14.

Department of Dermatology, Icahn School of Medicine at Mt Sinai, New York, New York; Department of Pediatrics, Icahn School of Medicine at Mt Sinai, New York, New York. Electronic address:

The emergence of the coronavirus disease 2019 (COVID-19) worldwide pandemic has been associated with a new constellation of cutaneous features in children. Among the unusual dermatologic presentations are the so-called COVID toes, inflammatory nodules of the feet and toes, sometimes involving the hands and fingers. These lesions mimic acral pernio, the synonym being chilblains. Read More

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Clinicopathologic correlations of COVID-19-related cutaneous manifestations with special emphasis on histopathologic patterns.

Clin Dermatol 2021 Jan-Feb;39(1):149-162. Epub 2020 Dec 14.

Unit of Dermatology, Department Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy.

Skin is one of target organs affected by the novel coronavirus SARS-CoV-2, and in response to the current COVID-19 pandemic, a fast body of literature has emerged on related cutaneous manifestations. Current perspective is that the skin is not only a bystander of the general cytokines storm with thrombophilic multiorgan injury, but it is directly affected by the epithelial tropism of the virus, as confirmed by the detection of SARS-CoV-2 in endothelial cells and epithelial cells of epidermis and eccrine glands. In contrast with the abundance of epidemiologic and clinical reports, histopathologic characterization of skin manifestations is limited. Read More

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COVID-19: The experience from Italy.

Clin Dermatol 2021 Jan-Feb;39(1):12-22. Epub 2020 Dec 17.

Dermatology Unit, ASST Lecco, Alessandro Manzoni Hospital, Lecco, Italy.

A wide range of cutaneous signs are attributed to COVID-19 infection. This retrospective study assesses the presence and impact of dermatologic manifestations related to the spread of COVID-19 in Lombardy, the geographic district with the first outbreak in Italy. A cohort of 345 patients with laboratory confirmed COVID-19 was collected from February 1, 2020 to May 31, 2020. Read More

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Management of a Child vs an Adult Presenting With Acral Lesions During the COVID-19 Pandemic: A Practical Review.

Cutis 2021 Mar;107(3):139-142

Ms. Clawson is from Eastern Virginia Medical School, Norfolk. Dr. Tabata is from the Department of Internal Medicine, Massachusetts General Hospital, Boston. Dr. Ko is from the Department of Dermatology, Stanford University, California.

During the coronavirus disease 2019 (COVID-19) pandemic, there has been a rise in the diagnosis of acral lesions, including chilblains-like lesions, ischemia, and retiform purpura. Understanding the differences in presentation and severity of illness between children and adult patients is important for physicians to understand risk stratification and management of these lesions. We reviewed the literature on the acral lesions seen in children and adults with COVID-19 infection to offer guidelines for diagnosis and treatment. Read More

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Clinical Characteristics and Transmission of COVID-19 in Children and Youths During 3 Waves of Outbreaks in Hong Kong.

JAMA Netw Open 2021 05 3;4(5):e218824. Epub 2021 May 3.

Department of Ophthalmology and Visual Sciences, Chinese University of Hong Kong, Hong Kong Special Administrative Region, China.

Importance: Schools were closed intermittently across Hong Kong to control the COVID-19 outbreak, which led to significant physical and psychosocial problems among children and youths.

Objective: To compare the clinical characteristics and sources of infection among children and youths with COVID-19 during the 3 waves of outbreaks in Hong Kong in 2020.

Design, Setting, And Participants: This cross-sectional study involved children and youths aged 18 years or younger with COVID-19 in the 3 waves of outbreaks from January 23 through December 2, 2020. Read More

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Inflammatory Skin Lesions in Three SARS-CoV-2 Swab-Negative Adolescents: A Possible COVID-19 Sneaky Manifestation?

Pediatr Rep 2021 Apr 9;13(2):181-188. Epub 2021 Apr 9.

Pediatric Dermatology, University of Bari Aldo Moro, 11, 70124 Bari, Italy.

Coronavirus disease 19 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is associated with various clinical manifestations, including skin lesions. In particular, during the COVID-19 pandemic lock-down period numerous chilblain-like lesions, mainly located on the feet, were observed in adolescents. The latter were often asymptomatic or associated with very mild respiratory symptoms. Read More

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New-onset chilblains in close temporal association to mRNA-1273 vaccination.

JAAD Case Rep 2021 Jun 3;12:12-14. Epub 2021 Apr 3.

Bighorn Mohs Surgery and Dermatology Center, La Jolla, California.

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Pernio after COVID-19 vaccination.

Br J Dermatol 2021 Apr 24. Epub 2021 Apr 24.

University of Texas Southwestern Medical Center, Dallas, TX, USA.

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Cutaneous Manifestations of COVID-19.

Cutis 2021 Feb;107(2):90-94

Ms. Schwartzberg is from the New York Institute of Technology College of Osteopathic Medicine, Old Westbury. Dr. Lin is from the Department of Dermatology, St. John's Episcopal Hospital, Far Rockaway, New York. Dr. Jorizzo is from the Department of Dermatology, Wake Forest Baptist Health, Winston-Salem, North Carolina, and Weill Cornell Medicine Dermatology, New York, New York.

Patients with coronavirus disease 2019 (COVID-19) present with multisystem signs and symptoms, including dermatologic manifestations. The recent literature has revealed that dermatologic manifestations of COVID-19 often are early onset and provide helpful cues to a timely diagnosis. We compiled the relevant emerging literature regarding the dermatologic manifestations of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) so that physicians can be aware of the various clinical cutaneous presentations in this time of high incidence of COVID-19. Read More

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February 2021

COVID-19 Toes and Other Skin Lesions During the Pandemic: Emerging Entities?

Int J Low Extrem Wounds 2021 Apr 23:15347346211011843. Epub 2021 Apr 23.

Diabetes Centre-Diabetic Foot Clinic, Democritus University of Thrace, Alexandroupolis, Greece.

There is accumulating evidence to indicate an association between coronavirus infectious disease 2019 (COVID-19) and clusters of incident cutaneous eruptions. Of these, chilblains-like perniosis have received widespread medical and media attention. These typically affect the toes, and have been called "COVID-toes. Read More

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Nailfold capillaroscopy findings in cutaneous lupus erythematosus patients with or without digital lesions and comparison with dermatomyositis patients: A prospective study.

Lupus 2021 Jul 15;30(8):1207-1213. Epub 2021 Apr 15.

Sorbonne Université, Faculté de Médecine Sorbonne Université, AP-HP, Service de Dermatologie et Allergologie, Hôpital Tenon, F-75020 Paris, France.

Background: Differential diagnosis between cutaneous lupus erythematosus (CLE) and dermatomyositis (DM) may be challenging if digital lesions occur.

Objectives: To compare nailfold capillaroscopy (NFC) findings in CLE patients with or without digital involvement, and to compare capillaroscopic findings between CLE patients with digital lesions and DM patients.

Methods: Prospective monocentric study including CLE and DM patients. Read More

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Chilblain-Like Lesions (CLL) Associated With COVID-19 ("COVID Toes"): A Systematic Review.

J Cutan Med Surg 2021 Apr 13:12034754211004575. Epub 2021 Apr 13.

12358 Department of Dermatology and Skin Science, University of British Columbia, Vancouver, BC, Canada.

Reports of chilblain-like lesions (CLL) coinciding with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection have been described in the literature, but this phenomenon has not been critically summarized. The aim of this paper is to summarize reports of CLL coinciding with SARS-CoV-2 infection to clarify the prevalence, clinical relevance, and prognostic value of these lesions. A literature search was conducted using the Embase, Pubmed, and Scopus databases from December 2019 to June 16, 2020 using the search terms ("COVID-19" OR "coronavirus" OR "2019-nCoV" OR "SARS-CoV-2") AND ("chilblain-like" OR "COVID toes" OR "acral"). Read More

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Cutaneous reactions reported after Moderna and Pfizer COVID-19 vaccination: A registry-based study of 414 cases.

J Am Acad Dermatol 2021 07 7;85(1):46-55. Epub 2021 Apr 7.

Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts; Medical Practice Evaluation Center, Mongan Institute, Massachusetts General Hospital, Boston, Massachusetts. Electronic address:

Background: Cutaneous reactions after messenger RNA (mRNA)-based COVID-19 vaccines have been reported but are not well characterized.

Objective: To evaluate the morphology and timing of cutaneous reactions after mRNA COVID-19 vaccines.

Methods: A provider-facing registry-based study collected cases of cutaneous manifestations after COVID-19 vaccination. Read More

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Sarcoidosis: A Clinical Overview from Symptoms to Diagnosis.

Cells 2021 Mar 31;10(4). Epub 2021 Mar 31.

Department of Internal Medicine, Lyon University Hospital, 69007 Lyon, France.

Sarcoidosis is a multi-system disease of unknown etiology characterized by the formation of granulomas in various organs. It affects people of all ethnic backgrounds and occurs at any time of life but is more frequent in African Americans and Scandinavians and in adults between 30 and 50 years of age. Sarcoidosis can affect any organ with a frequency varying according to ethnicity, sex and age. Read More

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A Review of COVID-19 Chilblains-like Lesions and their Differential Diagnosis.

Adv Skin Wound Care 2021 Mar 12. Epub 2021 Mar 12.

Medical Student, Faculty of Medicine, University of Toronto, Ontario, Canada Dermatology Resident, Department of Dermatology, University of Toronto, Ontario, Canada Medical Student, Faculty of Medicine, University of Toronto, Ontario, Canada Pediatric Dermatologist, Section of Dermatology, Division of Pediatric Medicine, The Hospital for Sick Children, University of Toronto, Ontario, Canada Editor-in-Chief Emeritus, Advances in Skin & Wound Care; the William Erdman Professor, Department of Physical Medicine and Rehabilitation; Senior Fellow, Institute on Aging; and Associate, Institute of Medicine and Bioengineering, University of Pennsylvania Health System, Philadelphia, Pennsylvania Staff Physician, Section of Dermatology, Division of Pediatric Medicine, The Hospital for Sick Children, University of Toronto, Ontario, Canada.

General Purpose: Forthcoming.

Target Audience: This continuing education activity is intended for physicians, physician assistants, nurse practitioners, and nurses with an interest in skin and wound care.

Learning Objectives/outcomes: Forthcoming. Read More

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[COVID-toes, a cutaneous sign of innate resistance to SARS-CoV-2].

Rev Med Suisse 2021 Mar;17(732):646-652

Service de dermatologie et vénéréologie, CHUV, 1011 Lausanne.

Since the beginning of the COVID-19 pandemic, dermatologists around the world have reported patients with chilblain-like skin lesions on their toes, called COVID-toes. Surprisingly, the majority of these patients do not develop COVID-19 symptoms, and their nasal swabs and serological tests are unable to confirm SARS-CoV-2 infection, despite a clear exposure to the virus. Recent evidence suggests that these patients mount a robust type I interferon response to SARS-CoV-2, making them resistant to the infection. Read More

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