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Dermatol Ther 2020 May 24:e13671. Epub 2020 May 24.

Department of Dermatology, Allergology and Venereology, Helsinki University Hospital.

Blood 2020 May;135(19):1719

Gundersen Lutheran Health System.

BMJ 2020 Apr 24;369:m1319. Epub 2020 Apr 24.

First point Healthcare, Launceston, Australia.

CMAJ 2020 Apr;192(16):E434

Division of Internal Medicine (Kobayashi), Nanmei-kai Miyagami Hospital, Kagoshima, Japan; Department of Infection Control and Prevention (Iwasaki), University of Fukui, Fukui, Japan.

J Hematol 2019 Sep 30;8(3):129-131. Epub 2019 Sep 30.

Department of Internal Medicine, John H. Stroger Jr Hospital of Cook County, 1969 West Ogden Avenue, Chicago, IL 60612, USA.

Pseudo thrombotic microangiopathy is a distinct clinical entity that is seen in patients with B12 deficiency. We describe a patient who presented with microangiopathic hemolytic anemia, thrombocytopenia, altered mentation and renal insufficiency. Thrombotic thrombocytopenic purpura was a major concern; however the peripheral blood smear showed hypersegmented neutrophils and the altered mental status as well as renal dysfunction improved with red cell transfusions. Read More

Blood Res 2020 Mar 30;55(1):69. Epub 2020 Mar 30.

Division of Hematolog/Oncology, Department of Internal Medicine, College of Medicine, Chungnam National University, Daejeon, Korea.

J Dent Sci 2020 Mar 9;15(1):42-49. Epub 2019 Dec 9.

Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan.

Background/purpose: Our previous study found that 143 of 884 burning mouth syndrome (BMS) patients have iron deficiency (ID). This study assessed whether all BMS patients with ID (so-called ID/BMS patients) had iron deficiency anemia (IDA) and evaluated whether the ID/BMS patients had significantly higher frequencies of anemia, hematinic deficiencies, hyperhomocysteinemia, and serum gastric parietal cell antibody (GPCA) positivity than healthy control subjects.

Materials And Methods: The blood hemoglobin (Hb) and serum iron, vitamin B12, folic acid, homocysteine, and GPCA levels in 143 ID/BMS patients and 442 healthy control subjects were measured and compared. Read More

J Dent Sci 2020 Mar 24;15(1):34-41. Epub 2019 Dec 24.

Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan.

Background/purpose: Our previous study found that 42 of 884 burning mouth syndrome (BMS) patients have vitamin B12 deficiency. This study assessed whether the vitamin B12-deficient BMS (B12D/BMS) patients had significantly higher frequencies of anemia, hematinic deficiencies, hyperhomocysteinemia, and serum gastric parietal cell antibody (GPCA) positivity than healthy control subjects and evaluated whether all B12D/BMS patients had pernicious anemia (PA).

Materials And Methods: The blood hemoglobin (Hb) and serum iron, vitamin B12, folic acid, homocysteine, and GPCA levels in 42 B12D/BMS patients and 442 healthy control subjects were measured and compared. Read More

Crit Rev Toxicol 2020 Feb 31;50(2):177-187. Epub 2020 Mar 31.

Department of Nonclinical Safety, Janssen Research and Development, Beerse, Belgium.

A 2016 plea for revision of the 1 mg/day upper level of folic acid intake prompted us to comprehensively review the 1945-2017 literature on folic acid hazards in subjects with low cyanocobalamin. The concept of folic acid treatment 'masking' the anemia in undiagnosed cyanocobalamin deficiency, thereby delaying the diagnosis of neuropathy, does not account for the dissociation between the deficiency's hematologic and neurologic manifestations. Possible risks of this concept were addressed by 1963-1971 FDA rulings, classifying all folic acid preparations as prescription-only drugs, delivering ≤1 mg daily. Read More

United European Gastroenterol J 2020 Mar 26;8(2):175-184. Epub 2019 Nov 26.

Department of Gastroenterology, Hepatology and Infectious Diseases, Otto-von-Guericke University Hospital, Magdeburg, Germany.

Objectives: Patients with autoimmune gastritis (AIG) are reported to have an increased risk of developing gastric cancer (GC). In this study, we assess the characteristics and outcomes of GC patients with AIG in a multicenter case-control study.

Methods: Between April 2013 and May 2017, patients with GC, including cancers of the esophagogastric junction (EGJ) Siewert type II and III, were recruited. Read More

BMJ Case Rep 2020 Mar 24;13(3). Epub 2020 Mar 24.

Department of Medicine, Madigan Army Medical Center, Tacoma, Washington, USA.

Vitamin B deficiency can be caused by a diverse group of aetiologies. One of the less common of these is an autoimmune condition pernicious anaemia, so named after the most common physiological manifestation of B deficiency: anaemia. However, B is also necessary for nervous system function and its depletion can lead to dysfunction of the posterior columns of the spinal cord resulting in subacute combined degeneration (SCD). Read More

Cureus 2020 Feb 8;12(2):e6921. Epub 2020 Feb 8.

Hematology/Oncology, Rochester Regional Health, Rochester, USA.

Thrombotic thrombocytopenic purpura (TTP) can often be life threatening and requires timely diagnosis and prompt initiation of plasmapharesis. Cobalamin deficiency can closely mimic TTP and distinguishing between the two diseases can prove to be a diagnostic challenge. Previously, cobalamin-related pseudo-TTP has been associated with pernicious anemia, dietary insufficiency and hereditary disorders of cobalamin activation. Read More

Clin Lab 2020 Mar;66(3)

Background: To determine the role of vitamin B12 deficiency in pernicious anemia and the efficacy of oral vitamin B12 replacement therapy given regardless of the etiology, and to compare the endoscopic and pathological findings in patients diagnosed with vitamin B12 deficiency.

Methods: The study included 216 patients, aged 18 - 65 years, diagnosed with vitamin B12 level < 200 pg/mL between May 2015 and May 2016. Evaluation was made of the demographic characteristics of the patients, diseases, drugs used, dietary habits, previous use of vitamin B12 replacement therapy, family history of vitamin B12 deficiency, laboratory test values, and neurological symptoms present at the time of presentation. Read More

Discov Med 2019 Nov-Dec;28(155):247-253

Section of Thrombosis and Benign Hematology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030, USA.

Pernicious anemia (PA), the commonest cause of cobalamin deficiency (CD) in the world, is an autoimmune disease of multifactorial origin and is characterized by chronic atrophic gastritis (CAG) and defective absorption of cobalamin from the terminal ileum due to interference by the intrinsic factor (IF) antibodies. PA-related CD is a lengthy process, which if untreated, can lead to irreversible hematological and neurological sequelae. Although safe and effective therapy is available and the management of PA is straightforward, the diagnosis of PA can be extremely difficult to obtain due to myriad and diverse clinical presentations, frequently coexisting diseases, and limitations of currently available diagnostic tests. Read More

Nestle Nutr Inst Workshop Ser 2020 28;93:91-102. Epub 2020 Jan 28.

Kamalnayan Bajaj Diabetology Research Centre, Diabetes Unit, King Edward Memorial Hospital Research Centre, Rasta Peth, Pune, India,

Vitamin B12 is a fascinating nutrient in that it is made by microbes but is essential for human metabolism. Humans can get it only from animal origin foods. Dietary deficiency rather than an absorption defect (Pernicious anemia, intrinsic factor defect) is the commonest cause of deficiency in the world, contributed by cultural and economic imperatives. Read More

J Pediatr Gastroenterol Nutr 2020 Feb;70(2):252-257

Division of Gastroenterology, Hepatology and Nutrition.

Objectives: To bring heightened awareness to a condition, autoimmune gastritis (AIG), which is a well-established entity in adults; however, rarely described in pediatrics. Currently, the literature describes AIG in pediatric patients who also suffer from other autoimmune disorders, which precedes the diagnosis of AIG, and often presents with unexplained anemia. Additionally, there have been case reports describing patients with immunodeficiencies and AIG, which progress to gastric adenocarcinoma. Read More

Fam Pract 2020 Feb;37(1):1-3

Department of Internal Medicine, Naval Hospital of Crete, Chania, Greece.

Best Pract Res Clin Endocrinol Metab 2019 Dec 11:101373. Epub 2019 Dec 11.

Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Viale Policlinico 155, 00161, Rome, Italy.

The association between autoimmune atrophic gastritis and thyroid disorders has been observed since the early 1960s and the expression "thyrogastric syndrome" was coined to indicate the presence of thyroid autoantibodies or autoimmune thyroid disease in patients with pernicious anemia, a late clinical stage of autoimmune atrophic gastritis. More recently, it was confirmed that autoimmune thyroid disorders, in particular Hashimoto's thyroiditis, may be frequently associated with other organ-specific, immune-mediated disorders, such as autoimmune atrophic gastritis or celiac disease. The association of Hashimoto's thyroiditis with autoimmune atrophic gastritis or celiac disease in adult patients is currently considered part of the polyglandular autoimmune syndromes which include several autoimmune disorders associated with an autoaggressive impairment of endocrine glands. Read More

Am J Med 2019 Dec 17. Epub 2019 Dec 17.

Department of Medicine, Limmattal Hospital, Schlieren, ZH, Switzerland; University of Zurich, Switzerland. Electronic address:

Front Immunol 2019 26;10:2733. Epub 2019 Nov 26.

Department of Medicine B and Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Ramat Gan, Israel.

To test the hypothesis that familial Mediterranean fever (FMF)-associated autoinflammation may exaggerate the tendency toward adaptive immunopathology or spondyloarthritis (SpA)-associated disorders including major histocompatibility complex (MHC) class I associated disorders but not classical MHC class II-associated disorders that exhibit transplacental autoimmunity including myasthenia gravis and pemphigus. Seven thousand seven hundred forty-seven FMF patients and 10,080 age- and sex-matched controls in the Clalit Health Services medical database were identified and compared in terms of prevalence of SpA-associated disorders. We also evaluated four classical and strong MHC class II-associated disorders, namely, pemphigus vulgaris, myasthenia gravis, sarcoidosis, and pernicious anemia, to ascertain whether such associations with SpA-spectrum disease were specific or merely reflected the non-specific consequences of innate immune system activation on driving divergent types of immunity. Read More

Muscle Nerve 2019 Dec 14. Epub 2019 Dec 14.

University of Virginia, Charlottesville, Virginia.

Neuropathies associated with nutritional deficiencies are routinely encountered by the practicing neurologist. Although these neuropathies assume different patterns, most are length-dependent, sensory axonopathies. Cobalamin deficiency neuropathy is the exception, often presenting with a non-length-dependent sensory neuropathy. Read More

Pol Arch Intern Med 2020 01 9;130(1):31-37. Epub 2019 Dec 9.

Department of Pathophysiology and Endocrinology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Katowice, Zabrze, Poland.

Introduction: Pernicious anemia (PA) is an autoimmune hematopoietic disease.

Objectives: The aim of the study was to determine autoantibodies involved in the pathogenesis of PA and the development of other autoimmune disorders such as connective tissue diseases and celiac disease. We also aimed to assess the potential usefulness of the specific diagnostic and screening tests in patients with PA. Read More

BMJ Case Rep 2019 Dec 5;12(12). Epub 2019 Dec 5.

Internal Medicine, University of Missouri Kansas City, Kansas City, Missouri, USA.

Vitamin B deficiency and its sequelae are well described and reported, especially in vegetarians. However, its association with haemodynamic instability is not well identified. We report a case of a young man, previously healthy, presenting with fever, hypotension requiring vasopressors and pancytopenia. Read More

Med Clin (Barc) 2020 May 25;154(9):344-347. Epub 2019 Nov 25.

Faculdade de Medicina de Campos, Hospital Escola Álvaro Alvim, Campos dos Goytacazes, Rio de Janeiro, Brazil.

Background: Patients with pernicious anemia (PA) have a higher prevalence of other autoimmune diseases. We assessed the correlation between PA and autoimmune thyroid diseases (AITD), and evaluated the risk factors for this association.

Methods: A longitudinal study was conducted involving patients with PA between 2010 and 2017. Read More

J Clin Med 2019 Nov 15;8(11). Epub 2019 Nov 15.

First Department of Medicine, Istituto di Ricovero e Cura a Carattere Scientifico San Matteo Hospital Foundation, University of Pavia, Piazzale Golgi 19, 27100 Pavia, Italy.

Background: Autoimmune atrophic gastritis (AAG) leads to iron and/or vitamin B12 malabsorption, with subsequent haematological alterations which could represent the sole clinical manifestation. We aimed to assess patterns of anaemia and micronutrient deficiencies in patients with AAG at the time of diagnosis.

Methods: Observational, multicentre, cross-sectional study including consecutive adult patients diagnosed with AAG within the last ten years. Read More

Rev Med Liege 2019 Nov;74(11):598-605

Service de Gastroentérologie, CHU Liège, Belgique.

Chronic autoimmune gastritis (CAG) is a continuum of histological changes in gastric mucosa including: atrophy, intestinal metaplasia, dysplasia and finally, the occurrence of a neoplasm (gastric Neuroendocrine Tumors -NETs- and adenocarcinoma). The association with Hashimoto and Graves-Basedow disease is known as the thyrogastric autoimmune syndrome. While Helicobacter pylori (Hp) infection may be associated with CAG, the role of the gastric microbiota is ill-defined. Read More

Clin Chem Lab Med 2020 Feb;58(3):424-429

Department of Radiology, University of Missouri, Columbia, MO, USA.

Background Vitamin B12 deficiency is common worldwide and is also linked to several diseases including autoimmune atrophic gastritis (AAG). The presence of anti-parietal cell antibodies (APCA) and/or intrinsic factor blocking antibodies (IFBA) is indicative of AAG that may develop into pernicious anemia. Both conditions are known to be associated with an increased risk of gastric carcinoma. Read More

Clin Pharmacol 2019 27;11:127-131. Epub 2019 Aug 27.

Department of Internal Medicine, University of South Alabama, Mobile, AL, USA.

Pseudo-thrombotic microangiopathy (pseudo-TMA) is a recognized, yet uncommon, clinical presentation of vitamin B12 deficiency. Patients with pseudo-TMA present with microangiopathic hemolytic anemia (MAHA), thrombocytopenia and schistocytes. They are often misdiagnosed as thrombotic thrombocytopenia purpura (TTP) and receive unnecessary therapy. Read More

J Pediatr Gastroenterol Nutr 2019 Oct 25. Epub 2019 Oct 25.

Attending Physician, Division of Gastroenterology, Hepatology and Nutrition, Children's Hospital Los Angeles, Assistant Clinical Professor of Pediatrics, Keck School of Medicine USC.

Objectives: To bring heightened awareness to a condition, autoimmune gastritis (AIG), which is a well-established entity in adults; however rarely described in pediatrics. Currently, the literature describes AIG in pediatric patients who also suffer from other autoimmune disorders, which precedes the diagnosis of AIG, and often presents with unexplained anemia. Additionally, there have been case reports describing patients with immunodeficiencies and AIG, which progress to gastric adenocarcinoma. Read More

J Formos Med Assoc 2020 Apr 1;119(4):813-820. Epub 2019 Nov 1.

Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan. Electronic address:

Background/purpose: Burning mouth syndrome (BMS) is characterized by burning sensation of the oral mucosa in the absence of clinically apparent oral mucosal alterations. This study evaluated the anemia, hematinic deficiencies, hyperhomocysteinemia, and serum gastric parietal cell antibody (GPCA) positivity in 884 BMS patients.

Methods: The blood hemoglobin (Hb) and serum iron, vitamin B12, folic acid, homocysteine, GPCA levels in 884 BMS patients were measured and compared with the corresponding levels in 442 age- and sex-matched healthy control subjects. Read More

Int J Neurosci 2020 Apr 12;130(4):343-347. Epub 2019 Nov 12.

Department of Radiology, PLA 148 Hospital, Zibo, Shandong, PR China.

: Anterior funiculus lesion is uncommon in subacute combined degeneration of the spinal cord with few data available. Aim of the study was to describe a case with the rare manifestation and summarize existing literatures.: We report a case of a 42-year-old woman with anterior and lateral funiculus lesions on cervicothoracic spine magnetic resonance imaging, who presented with unsteady gait, sensory level and weakness of lower limbs. Read More

Arch Pathol Lab Med 2019 11;143(11):1327-1331

From the Department of Pathology, University of Michigan Medical School, Ann Arbor.

Context.—: Autoimmune gastritis (AG) is a corpus-restricted chronic atrophic gastritis associated with intrinsic factor deficiency, either with or without pernicious anemia. Autoimmune gastritis is a microscopic disease because patients present with no or vague symptoms, and clinicians rarely find endoscopic changes. Read More

J Formos Med Assoc 2020 Mar 18;119(3):720-727. Epub 2019 Oct 18.

Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan. Electronic address:

Background/purpose: Our previous study found that 56 of 1064 atrophic glossitis (AG) patients have vitamin B12 deficiency. This study assessed whether the AG patients with vitamin B12 deficiency (B12D/AG patients) had significantly higher frequencies of anemia, hematinic deficiencies, hyperhomocysteinemia, and serum gastric parietal cell antibody (GPCA) positivity than healthy control subjects.

Methods: The blood hemoglobin (Hb) and serum iron, vitamin B12, folic acid, homocysteine, and GPCA levels in 56 B12D/AG patients and 532 healthy control subjects were measured and compared. Read More

N Engl J Med 2019 Oct;381(16):1568

National University of Singapore, Singapore, Singapore

ACG Case Rep J 2019 Apr 11;6(4):e00046. Epub 2019 Apr 11.

John H Stroger Jr. Hospital of Cook County, Chicago, IL.

Hypoxic hepatitis or ischemic hepatitis is most commonly encountered in critical care patients, most of whom have shock states secondary to cardiac or respiratory failure. We report a case of severe pernicious anemia predisposing to hypoxic hepatitis that had a good prognosis with simple treatment. Care should be taken in management of severe anemia, interpretation of serum vitamin B12 levels after blood transfusion, and the use of intravenous fluids. Read More

J Formos Med Assoc 2020 Feb 10;119(2):587-594. Epub 2019 Oct 10.

Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan. Electronic address:

Background/purpose: Our previous study found that 180 of 1064 atrophic glossitis (AG) patients have iron deficiency. This study assessed whether all AG patients with iron deficiency (so-called ID/AG patients) had iron deficiency anemia (IDA) and evaluated whether the ID/AG patients had significantly higher frequencies of anemia, hematinic deficiencies, hyperhomocysteinemia, and serum gastric parietal cell antibody (GPCA) positivity than healthy control subjects.

Methods: The blood hemoglobin (Hb) and serum iron, vitamin B12, folic acid, homocysteine, and GPCA levels in 180 ID/AG patients and 532 healthy control subjects were measured and compared. Read More

PLoS One 2019 10;14(10):e0223000. Epub 2019 Oct 10.

Medical Research Council Lifecourse Epidemiology Unit, University of Southampton, Southampton, United Kingdom.

Background: Vitamin B-12 deficiency is often considered synonymous with pernicious anemia, a rare condition in which severe malabsorption of the vitamin requires high-dose parenteral treatment. In developing countries such as India, inadequate dietary intake of B-12 due to socio-cultural factors leads to widely prevalent asymptomatic low B-12 status. In this scenario, lower doses of oral B-12 may be effective, safer and more affordable. Read More

Brain Nerve 2019 Sep;71(9):1003-1012

Department of Neurology, Saiseikai Matsusaka General Hospital.

We present a case of a 73-year-old female who developed subacute memory disturbance, reduced consciousness and quadriparesis following pernicious anemia. Brain magnetic resonance imagings (MRI) in diffusion weighted, T2 weighted and fluid attenuated inversion recovery (FLAIR) images revealed hyperintensities in bilateral frontal, parietal, temporal and occipital cortices, left thalamus, bilateral splenium of corpus callosum, and bilateral subcortical white matters. Brain gadolinium enhanced T₁ weighted MRI revealed very slight post-contrast enhancement lesions in the right posterior temporal region and bilateral parietal regions. Read More

Cancer Epidemiol Biomarkers Prev 2019 12 9;28(12):2022-2029. Epub 2019 Sep 9.

Metabolic Epidemiology Branch, Division of Cancer Epidemiology & Genetics, National Cancer Institute, National Institutes of Health, Rockville, Maryland.

Background: Autoimmune gastritis is understudied and possibly associated with gastric noncardia adenocarcinoma (GNCA) and esophageal squamous cell carcinoma (ESCC) in Western populations when it presents as pernicious anemia.

Methods: A nested case-control study within a Chinese cohort included 100 ESCC, 200 gastric cardia adenocarcinoma (GCA), and 200 GNCA cases diagnosed between 1986 and 2001 and 400 controls. Serostatus of antiparietal cell antibodies (APCA), antibodies, and pepsinogens were measured using commercial kits and serum collected at baseline. Read More

Mayo Clin Proc 2019 09;94(9):1904

Mayo Clinic College of Medicine, Hospital Internal Medicine, Mayo Clinic, Rochester, MN.

J Formos Med Assoc 2020 Jan 20;119(1 Pt 3):544-552. Epub 2019 Aug 20.

Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan. Electronic address:

Background/purpose: Our previous study found that 127 of 1064 atrophic glossitis (AG) patients have hyperhomocysteinemia. This study assessed whether the AG patients with hyperhomocysteinemia had significantly higher frequencies of anemia, hematinic deficiencies, and serum gastric parietal cell antibody (GPCA) positivity than AG patients without hyperhomocysteinemia or healthy control subjects.

Methods: The blood hemoglobin (Hb) and serum iron, vitamin B12, folic acid, homocysteine, and GPCA levels in 127 AG patients with hyperhomocysteinemia, 937 AG patients without hyperhomocysteinemia, and 532 healthy control subjects were measured and compared. Read More

Cureus 2019 Jun 10;11(6):e4870. Epub 2019 Jun 10.

Internal Medicine, St. Francis Medical Center, Seton Hall University, Trenton, USA.

Pernicious anemia (PA) is a common cause of megaloblastic anemia throughout the world, especially in Northern European whites. This disease is characterized by the deficiency of vitamin B12 due to the presence of anti-intrinsic factor and anti-parietal cell antibodies which inhibit the absorption of the vitamin B12. In cases of severe vitamin B12 deficiency, patients can suffer debilitating complications such as described in our case. Read More

Eur Respir J 2019 Nov 14;54(5). Epub 2019 Nov 14.

Institute of Applied Health Research, University of Birmingham, Birmingham, UK.

Introduction: The association between allergic diseases and autoimmune disorders is not well established. Our objective was to determine incidence rates of autoimmune disorders in allergic rhinitis/conjunctivitis (ARC), atopic eczema and asthma, and to investigate for co-occurring patterns.

Methods: This was a retrospective cohort study (1990-2018) employing data extracted from The Health Improvement Network (UK primary care database). Read More

J Am Acad Dermatol 2020 Mar 17;82(3):628-633. Epub 2019 Jul 17.

Department of Dermatology, Keck School of Medicine of University of Southern California, Los Angeles, California. Electronic address:

Background: Vitiligo is associated with medical conditions, primarily autoimmune disorders; however, only a few studies in the United States have investigated these associations.

Objective: Our purpose was to investigate the diseases associated with vitiligo in the New York, New York, population and evaluate if these associations differ by race/ethnicity and sex.

Methods: In this retrospective study, we analyzed data collected from the medical records of 1487 vitiligo patients seen at New York University during a 10-year period. Read More

J Formos Med Assoc 2019 Nov 16;118(11):1515-1521. Epub 2019 Jul 16.

Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan. Electronic address:

Background/purpose: Macrocytosis is defined as having the mean corpuscular volume (MCV) ≧ 100 fL. This study evaluated whether 41 atrophic glossitis (AG) patients with macrocytosis had significantly higher frequencies of anemia, hematinic deficiencies, hyperhomocysteinemia, and serum gastric parietal cell antibody (GPCA) positivity than 532 healthy control subjects or 1064 AG patients.

Methods: Complete blood count, serum iron, vitamin B12, folic acid, homocysteine, and GPCA levels in 41 AG patients with macrocytosis, 1064 AG patients, and 532 healthy control subjects were measured and compared. Read More

Blood Res 2019 Jun 25;54(2):149-151. Epub 2019 Jun 25.

Department of Hematology, Antalya Training and Research Hospital, Antalya, Turkey.

Intern Med 2019 Oct 10;58(20):2907-2913. Epub 2019 Jul 10.

Department of General Internal Medicine, Kawasaki Medical School, Japan.

Objective To evaluate the prevalence of autoimmune gastritis in patients with histologically proven nonalcoholic steatohepatitis (NASH). Methods A total of 33 patients with NASH and 143 patients with chronic liver disease (66, 24, 22, 10, 1, and 21 patients with hepatitis C, hepatitis B, autoimmune hepatitis/primary biliary cholangitis, non-B/non-C hepatitis, fatty liver, and alcoholic disease, respectively) who underwent upper gastrointestinal endoscopy between January 2013 and August 2016 were retrospectively assessed to determine the prevalence of autoimmune gastritis. The clinical characteristics of these patients with NASH and autoimmune gastritis were examined, and the clinical characteristic and biomarkers were compared between patients with NASH with and without autoimmune gastritis. Read More

Gut 2019 09 5;68(9):1545-1575. Epub 2019 Jul 5.

Gastroenterology, IPO Porto, Porto, Portugal.

Gastric adenocarcinoma carries a poor prognosis, in part due to the late stage of diagnosis. Risk factors include infection, family history of gastric cancer-in particular, hereditary diffuse gastric cancer and pernicious anaemia. The stages in the progression to cancer include chronic gastritis, gastric atrophy (GA), gastric intestinal metaplasia (GIM) and dysplasia. Read More

J Community Hosp Intern Med Perspect 2019 19;9(3):240-243. Epub 2019 Jun 19.

Hematology, Riverside University Health System Medical Center, Moreno Valley, CA, USA.

Severe cytopenias (anemia, thrombocytopenia, neutropenia or any combination of these) are common causes of ER visits and hospital admissions. In adults, the etiology of cytopenias has a broad differential diagnosis including vitamin and mineral deficiencies, autoimmune conditions, infections, bone marrow failure disorders, or malignancies. We present a case of severe anemia and thrombocytopenia who was initially diagnosed with myelodysplastic syndrome (MDS) based on the results of a bone marrow biopsy. Read More