Search Our Scientific Publications & Authors

Ann Med Surg (Lond) 2020 Aug 24;56:121-124. Epub 2020 Jun 24.

Departement of Surgery, Dr. Soetomo Hospital Surabaya, Faculty of Medicine, Universitas Airlangga, Jl. Mayjen Prof. Dr. Moestopo 47, Surabaya, 60132, Indonesia.

Introduction: Very-short proximal jejunal stump anastomosis leak has been a major problem in surgery and it causes high postoperative morbidity and mortality. However, using a Bishop-Koop Modification technique anastomosis with decompression and nutrition tube, we can completely cure the patient with this case.

Presentation Of Case: A 61-year-old man came to the emergency room with generalized peritonitis and sepsis, on emergency laparotomy we found a perforation from solid tumor located in the proximal jejunum, 20 cm distal to ligament of Treitz. Read More

Cureus 2020 May 21;12(5):e8220. Epub 2020 May 21.

Urology, Pondicherry Institute of Medical Sciences, Pondicherry, IND.

Urachus is an embryonic organ related to the bladder that degenerates after birth. Defective obliteration of the urachus leads to urachal malformations, the most common of which is a urachal cyst. A urachal cyst is often misdiagnosed due to its myriad presentations. Read More

Cureus 2020 May 9;12(5):e8036. Epub 2020 May 9.

Pediatrics Section, Marie Curie Children's Emergency Hospital, Bucharest, ROU.

Perinatal tuberculosis (TB) is a rare disease with nonspecific clinical symptoms that can result in delayed treatment, and contribute to high morbidity and mortality. We report a case of perinatal TB in a 25-day-old newborn who presented with fever, respiratory distress, disseminated intravascular coagulation (DIC), and marked abdominal distension with hepatosplenomegaly. Further workup revealed culture negative sepsis, peritonitis, and diffuse nodular infiltrate in the lungs, liver, and spleen. Read More

Khirurgiia (Mosk) 2020 (5):27-33

Pavlov First Saint Petersburg State Medical University, Saint Petersburg, Russia.

Objective: To identify the most important high risk criteria for predicting course of disease, as well as optimal preoperative preparation and surgical strategy in patients with secondary peritonitis.

Material And Methods: A prospective study enrolled 43 patients with diffuse secondary peritonitis.

Results: Significant predictors were Charlson's comorbidity index (=0. Read More

Orv Hetil 2020 06;161(23):977-979

Központi Radiológiai Osztály,Markusovszky Egyetemi Oktatókórház Szombathely.

Primary peritonitis is very rare in healthy children without predisposing factors. In the absence of unique factors and signs, the clinical picture does not differ from secondary peritonitis. Therefore, the diagnosis is almost always an intraoperative diagnosis. Read More

Surg Infect (Larchmt) 2020 May 20. Epub 2020 May 20.

Infectious Diseases Department, Hospital Universitari Vall d'Hebron, Barcelona, Spain.

Bacterial infections are a common complication after liver transplantation. Usually, abdominal drains are placed at the end of the surgical procedure. The usefulness of routine drain tip culture has not been investigated. Read More

Front Immunol 2020 30;11:828. Epub 2020 Apr 30.

Immunology Department, Institute of Immunology and Transfusion Medicine, University Medicine Greifswald, Greifswald, Germany.

Although antigen-specific priming of antibody responses is impaired during sepsis, there is nevertheless a strong increase in IgM and IgG serum concentrations. Using colon ascendens stent peritonitis (CASP), a mouse model of polymicrobial abdominal sepsis, we observed substantial increases in IgM as well as IgG of all subclasses, starting at day 3 and peaking 2 weeks after sepsis induction. The dominant source of antibody-secreting cells was by far the spleen, with a minor contribution of the mesenteric lymph nodes. Read More

Intern Med 2020 15;59(10):1257-1265. Epub 2020 May 15.

Department of General Medicine, Saga University Hospital, Japan.

Objective Acute abdominal pain (AAP) of diverse etiology is a common chief complaint of patients who present to the emergency department (ED). AAP may pose a diagnostic challenge to physicians in training. We aimed to evaluate whether or not resident trainee doctors examine patients presenting with AAP in a Japanese acute-care hospital following Kendall's diagnostic algorithm. Read More

Case Rep Surg 2020 25;2020:5060962. Epub 2020 Mar 25.

Department of Surgery, West Virginia University School of Medicine, One Medical Center Drive, PO Box 9238, Morgantown, WV 26508, USA.

Iatrogenic gastrointestinal perforation is a rare, life-threatening complication of endoscopic procedures, which requires either endoscopic or surgical repair. We report the account of an 82-year-old woman with an iatrogenic gastric perforation of a hiatal hernia secondary to an endoscopic retrograde cholangiopancreatography (ERCP) procedure. Despite immediate recognition of the complication and endoscopic closure with through-the-scope (TTS) clips, the patient developed mediastinitis, peritonitis, and sepsis. Read More

Am Surg 2020 Apr;86(4):308-312

From the *School of Medicine, Griffith University, Gold Coast, Australia and.

Acute diverticulitis is an emergency surgical condition that is commonly managed an acute surgical unit model. Operative surgery is indicated in selected situations including generalized peritonitis or fistulous disease; however, limited data exist on how borderline patients potentially needing surgery may be salvaged by close clinical management with modern interventional techniques. The aims of the study were to identify the operative surgery rates in acute diverticulitis and predictors for identifying patients with complicated diverticulitis. Read More

World J Emerg Surg 2020 May 7;15(1):32. Epub 2020 May 7.

Department of Emergency Surgery, Parma Maggiore Hospital, Parma, Italy.

Acute colonic diverticulitis is one of the most common clinical conditions encountered by surgeons in the acute setting. An international multidisciplinary panel of experts from the World Society of Emergency Surgery (WSES) updated its guidelines for management of acute left-sided colonic diverticulitis (ALCD) according to the most recent available literature. The update includes recent changes introduced in the management of ALCD. Read More

J Surg Res 2020 Aug 13;252:231-239. Epub 2020 Apr 13.

Department of Gastroenterological and Pediatric Surgery, Oita University Faculty of Medicine, Oita, Japan.

Background: Standard treatment for diffuse peritonitis due to colorectal perforation may be insufficient to suppress inflammatory reaction in sepsis. Thus, developing new treatments is important. This study aimed to examine whether intraperitoneal irradiation by artificial sunlight suppresses inflammatory reaction in a lipopolysaccharide (LPS)-induced peritonitis model after surgical treatments. Read More

Ann Med Surg (Lond) 2020 May 1;53:20-22. Epub 2020 Apr 1.

Department of Surgery, San Salvatore Hospital. Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, Italy.

Ingested toothpicks are a relatively rare event, but they may cause serious gut injuries and can be listed among rare causes of perforation, peritonitis, sepsis or death. Unless the foreign bodies were intentionally swallowed, many patients who ingested them fail to remember the event and they do not refer it during the medical history collection; this makes diagnosis problematic. In this work, a case of perforation of the sigmoid colon is described, caused by a toothpick ingestion. Read More

BMC Pediatr 2020 Apr 6;20(1):151. Epub 2020 Apr 6.

Department of Pediatrics, University Hospital Liège, Liège, Belgium.

Background: Unusual clinical presentation of acute appendicitis in preschool children leads to misdiagnosis and complications. We aimed to analyze the influence of age on clinical presentation, laboratory findings and complications in preschool children with acute appendicitis.

Methods: From January 2012 until December 2017, 29 children younger than 6 years of age (median 50 months) with acute appendicitis were enrolled in this retrospective study. Read More

Int J Infect Dis 2020 Jun 30;95:115-117. Epub 2020 Mar 30.

Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador-BA, Brazil. Electronic address:

Introduction: Biliary ascariasis, although uncommon, can lead to infectious complications and severe outcomes. This study reported three patients with biliary ascariasis and who were admitted to a paediatric hospital in Salvador, Brazil.

Case Reports: Case 1: A 1-year-old boy, with HIV, hospitalised with diarrhoea, fever, pain, and abdominal distension. Read More

Angiol Sosud Khir 2020 ;26(1):113-120

Municipal Clinical Hospital named after V.V. Veresaev, Moscow Healthcare Department, Moscow, Russia.

Described in the article are the results of treating a total of 44 patients who endured repeat operations for infection of aortofemoral bifurcation allografts over the period between 2001 and 2018. These patients had previously undergone reconstructive operations using various synthetic grafts for lower limb ischaemia on the background of lower-limb artery atherosclerosis and infrarenal aortic aneurysms. Infection of synthetic vascular allografts in these patients was observed both in the immediate and remote postoperative periods. Read More

J Med Case Rep 2020 Mar 9;14(1):40. Epub 2020 Mar 9.

Department of Obstetrics and Gynecology, University of the Philippines - Philippine General Hospital, Manila, Philippines.

Background: Vaginal cuff dehiscence is a rare but potentially grave complication after total hysterectomy. Abdominal or pelvic contents are at risk of evisceration through the vaginal opening. It is associated with significant risk for patient morbidity, such as peritonitis, bowel injury, and sepsis. Read More

Vet Med (Auckl) 2020 27;11:25-30. Epub 2020 Feb 27.

Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, MI, USA.

This report describes two cases of mesenteric lymphadenitis leading to septic peritonitis in two young dogs. The cases were similar in presentation, diagnosis, treatment, and length of hospitalization. Both cases presented with clinical signs of vomiting, abdominal pain, and fever and were treated successfully via surgical debridement, omentalization, and antibiotic therapy. Read More

Ann Palliat Med 2020 Mar 25;9(2):488-492. Epub 2020 Feb 25.

Department of Gastroenterology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510000, China.

Post-polypectomy syndrome (PPS) results from electrocoagulation injury to the bowel wall that induces a transmural burn and localized peritonitis. It has a good prognosis; however, there are exceptions when complications are observed. We here report a case of a 50-year-old man who developed lumbosacral pain and high fever with chills four days after colonoscopy, during which polypectomy was performed by endoscopic mucosal resection (EMR) and argon plasma coagulation (APC). Read More

World J Surg 2020 Jul;44(7):2185-2190

Department of Visceral, Minimally Invasive and Oncologic Surgery, Marien Hospital Düsseldorf, Rochusstr. 2, 40479, Düsseldorf, Germany.

Background: Secondary peritonitis is associated with high rates of morbidity and mortality. Data on the effect of staged re-laparotomy or re-laparoscopy as a surgical option in the management of abdominal sepsis due to secondary peritonitis are limited and conflicting. Herein, we report the outcomes of patients undergoing staged peritoneal lavage (SPL) for secondary peritonitis in our department. Read More

Cir Cir 2020 ;88(2):150-153

Clínica de Atención Integral de la Sepsis Abdominal. Hospital General de México Dr. Eduardo Liceaga, Ciudad de México, México.

Background: Biomarker combinations can improve timely diagnosis and survival.

Objective: To determine the usefulness of serum procalcitonin concentration (PCT), C-reactive protein (PCR) and the PCR / PCT index as predictors of mortality.

Method: Retrospective study of patients diagnosed with abdominal sepsis during the period from April 2017 to February 2018. Read More

Insights Imaging 2020 Feb 21;11(1):31. Epub 2020 Feb 21.

Department of Radiology, University Hospital of Heraklion, Faculty of Medicine-University of Crete, Stavrakia, Voutes 21110, Heraklion, Crete, Greece.

Gastrointestinal tract (GIT) perforation is a common medical emergency associated with considerable mortality, ranging from 30 to 50%. Clinical presentation varies: oesophageal perforations can present with acute chest pain, odynophagia and vomiting, gastroduodenal perforations with acute severe abdominal pain, while colonic perforations tend to follow a slower progression course with secondary bacterial peritonitis or localised abscesses. A subset of patients may present with delayed symptoms, abscess mimicking an abdominal mass, or with sepsis. Read More

Updates Surg 2020 Mar 19;72(1):185-191. Epub 2020 Feb 19.

Department of Emergency and Trauma Surgery, Maggiore Hospital, Parma, Italy.

Diffuse peritonitis represents a life-threatening complication of acute appendicitis (AA). Whether laparoscopy is a safe procedure and presents similar results compared with laparotomy in case of complicated AA is still a matter of debate. The objective of this study is to compare laparoscopic (LA) and open appendectomy (OA) for the management of diffuse peritonitis caused by AA. Read More

Sci Rep 2020 Jan 31;10(1):1631. Epub 2020 Jan 31.

Department of General and Digestive Surgery, Hospital Universitario Doctor Peset, Valencia, Spain.

Age-adjusted Charlson Comorbidity Index (a-CCI) score has been used to weight comorbid conditions in predicting adverse outcomes. A retrospective cohort study on adult patients diagnosed with complicated intra-abdominal infections (cIAI) requiring emergency surgery was conducted in order to elucidate the role of age and comorbidity in this scenario. Two main outcomes were evaluated: 90-day severe postoperative complications (grade ≥ 3 of Dindo-Clavien Classification), and 90-day all-cause mortality. Read More

Shock 2020 Jan 20. Epub 2020 Jan 20.

Department of Anesthesiology, University of California, San Francisco, San Francisco, California.

Intra-abdominal infection is the second most common cause of sepsis, and the mortality rate from abdominal sepsis remains high. High molecular weight (HMW) hyaluronic acid (HA) has been studied in sterile injury models as an anti-inflammatory and anti-permeability agent. This study evaluated the therapeutic effects of intraperitoneal HMW HA administration in mice with peritonitis-induced sepsis. Read More

Eur J Histochem 2020 Jan 10;64(1). Epub 2020 Jan 10.

Clinic of Surgery, Marche Polytechnic University, Ancona .

The tissue inflammatory response can influence the outcome of anastomotic healing. Anastomotic leakage represents a dreadful complication after gastrointestinal surgery, in particular sepsis and intra-abdominal infections impair the restorative process of colic anastomoses. It has been debated whether the administration of non-steroidal anti-inflammatory drugs (NSAIDs) is a risk factor for dehiscence, since many patients receive NSAIDs in the early postoperative period. Read More

Mediators Inflamm 2019 5;2019:8971036. Epub 2019 Dec 5.

General Surgery Department, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy.

Animal models are widely used to replicate human intra-abdominal infections. Different methodologies have been described and proposed in the scientific literature, including injection and surgical models. The aim of this review is to recapitulate the advantages and disadvantages of each method to help choose the most appropriate model for individual experimental purposes. Read More

World J Gastrointest Surg 2019 Dec;11(12):422-432

Division of Trauma and Surgical Critical Care, Department of Surgery, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 137-701, South Korea.

Background: Polymyxin B hemoperfusion (PMX-HP) has been used as a treatment for intra-abdominal septic shock by absorbing and removing endotoxins of gram-negative bacilli.

Aim: To investigate the clinical efficacy of PMX-HP in patients with gram-negative septic shock who underwent abdominal surgery.

Methods: From January 2012 to December 2018, patients who had septic shock secondary to peritonitis were enrolled. Read More

BMJ Case Rep 2019 Dec 18;12(12). Epub 2019 Dec 18.

Division of Surgery, Christian Medical College and Hospital Vellore, Vellore, Tamil Nadu, India.

A 26-year-old man who was previously well presented to the emergency in septic shock. He had a preceding history of fever, right upper abdominal pain and jaundice. On examination, there was tenderness over the right hypochondrium and epigastrium, without features of generalised peritonitis. Read More

Int J Emerg Med 2019 Dec 19;12(1):41. Epub 2019 Dec 19.

D.O. Assistant Clinical Professor, Beaumont Hospital, Botsford Campus, Teaching hospital of Michigan State University, Department of Emergency Medicine, Farmington Hills, MI, USA.

Background: Diagnosing appendicitis within the pediatric population can be challenging, whether it be a neonate with irritability or a toddler with flank pain. Symptoms may mimic a viral illness, constipation, urinary tract infection, or intussusception, all of which are more common in this age group when compared with appendicitis. While a ruptured appendicitis can result in an intra-abdominal abscess, peritonitis, and/or shock, the development of a pyogenic hepatic abscess is extremely rare. Read More

Khirurgiia (Mosk) 2019 (12):106-110

Department of Surgical Diseases #1, Avicenna Tajik State Medical University, Dushanbe, Republic of Tajikistan.

The concept of pathogenesis of peritonitis and abdominal sepsis are discussed in the article. Significant scientific findings devoted to this issue occurred in recent years. Nevertheless, there is still no unity in understanding the pathogenesis of peritonitis. Read More

Ann Ital Chir 2019 ;90:432-441

Background: The treatment of acute diverticulitis is a matter of debate and has undergone significant changes. Currently the main focus of surgical treatment is a more conservative and less invasive management.

Aims And Methods: To focus the role of surgery in the treatment of acute diverticulitis, the Authors have conducted a review of the literature of the last two decades and have revised critically their own experience. Read More

Rev Esp Quimioter 2020 02 3;33(1):18-23. Epub 2019 Dec 3.

Fco Javier Redondo Calvo, Servicio de Anestesilogía y Reanimación. Unidad de Investigación Traslacional. Hospital General Universitario de Ciudad Real. C/Obispo General Torija s/n.13005. Ciudad Real. Spain.

Objective: The aim of the study was to develop a model of abdominal sepsis in the experimental animal.

Methods: Sprague-Dawley male rats of 5 weeks (N=39) were used. Initially, a pilot study (N = 9) was performed and distributed in 3 groups with 1cc inoculum of Escherichia coli ATCC 25922 intraperitoneally at concentrations of 10E8, 10E9 and 10E10 CFU. Read More

Int J Colorectal Dis 2019 Dec 12;34(12):2111-2120. Epub 2019 Nov 12.

Emergency Surgery Unit, University of Pisa, New Santa Chiara Hospital, Via Paradisa 2, 56124, Pisa, Italy.

Purpose: Laparoscopic peritoneal lavage (LPL) is feasible in selected patients with pelvic abscess and generalized purulent peritonitis caused by acute diverticulitis. We aimed to compare LPL and laparoscopic sigmoidectomy (LS) in complicated acute diverticulitis.

Methods: This prospective, observational, multicenter study included patients with a pelvic abscess not amenable to conservative management and patients with Hinchey III acute diverticulitis, from 2015 to 2018. Read More

Int J Surg Case Rep 2019 22;65:148-151. Epub 2019 Oct 22.

Department of General Surgery, Tokyo-Nishi Tokushukai Hospital, 196-0003, Matsubara 3-1-1, Akishima, Tokyo, Japan. Electronic address:

Introduction: Large-bowel perforation can lead to critical sepsis, and urgent intervention including surgery is indispensable to control systemic infection. Here, we describe a strategy for large-bowel perforation using a ventriculoperitoneal shunt.

Case Presentation: A 74-year-old Japanese female with a history of cerebral aneurysm clipping and ventriculoperitoneal shunting due to aneurysmal subarachnoid hemorrhage presented with lower abdominal pain, fever, and disturbed consciousness. Read More

Intensive Care Med 2019 12 29;45(12):1703-1717. Epub 2019 Oct 29.

General Internal Medicine, Infectious Diseases, and Psychometric Medicine, Ghent University Hospital, Ghent, Belgium.

Purpose: To describe the epidemiology of intra-abdominal infection in an international cohort of ICU patients according to a new system that classifies cases according to setting of infection acquisition (community-acquired, early onset hospital-acquired, and late-onset hospital-acquired), anatomical disruption (absent or present with localized or diffuse peritonitis), and severity of disease expression (infection, sepsis, and septic shock).

Methods: We performed a multicenter (n = 309), observational, epidemiological study including adult ICU patients diagnosed with intra-abdominal infection. Risk factors for mortality were assessed by logistic regression analysis. Read More

Acta Clin Belg 2019 Dec 30;74(6):435-438. Epub 2018 Oct 30.

Department of Microbiology, AZ Groeninge , Kortrijk , Belgium.

Read More

Eur J Trauma Emerg Surg 2019 Oct 22. Epub 2019 Oct 22.

Department of general and Digestive Surgery, Fundación Jiménez-Díaz University Hospital and Instituto de Investigación Sanitaria (IIS-FJD), Madrid, Spain.

Purpose: The abdomen is the second most common source of sepsis and secondary peritonitis, which likely lead to death. In the present study, we hypothesized that instillation of local anesthetics into the peritoneum might mitigate the systemic inflammatory response syndrome (SIRS) in the open abdomen when combined with negative-pressure therapy (NPT) to treat severe peritonitis.

Methods: We performed a study in 21 pigs applying a model of sepsis based on ischemia/reperfusion and fecal spread into the peritoneum. Read More

J Vet Emerg Crit Care (San Antonio) 2019 Nov 21;29(6):635-642. Epub 2019 Oct 21.

Angell Animal Medical Center, Boston, Massachusetts.

Objective: To evaluate bacterial isolates, antimicrobial drug susceptibility, and change in resistance among pre- and post-lavage culture samples in dogs with septic peritonitis.

Design: Prospective observational study.

Setting: Private practice referral hospital. Read More

Int J Surg 2019 Nov 11;71:182-189. Epub 2019 Oct 11.

Department of Gastrointestinal Surgery, Lilavati Hospital and Research Centre, Mumbai, Maharashtra, India.

Background: Diverticulitis is one of the most common gastrointestinal diseases in western population. Colonic resection is recommended by international guidelines as a routinely used technique for purulent diverticulitis. Laparoscopic lavage was introduced as a non-resection alternative. Read More

Acute Med Surg 2019 Oct 1;6(4):400-403. Epub 2019 Aug 1.

Center for Integration of Advanced Medicine, Life Science and Innovative Technology Kyushu University Hospital Fukuoka Japan.

Background: Open abdomen management (OAM) is used not only for trauma but also for treatment of peritonitis. However, the rate of successful fascial closure in patients with OAM remains low.

Case Presentation: The patient was a 38-year-old morbidly obese man who underwent laparoscopic sleeve gastrectomy. Read More

J Am Vet Med Assoc 2019 10;255(8):915-925

Objective: To determine complication rates for dogs in which full-thickness large intestinal incisions were performed, assess potential risk factors for death during hospitalization and for intestinal dehiscence following these surgeries, and report short-term mortality rates for these patients.

Animals: 90 dogs.

Procedures: Medical records of 4 veterinary referral hospitals were reviewed to identify dogs that underwent large intestinal surgery requiring full-thickness incisions. Read More

J Med Microbiol 2019 Nov;68(11):1596-1603

Department of Molecular and Developmental Medicine, University of Siena, Siena, Italy.

is becoming a growing public health challenge, especially for its ability to cause infections in immunocompromised patients. This bacterium is a Gram+coccus, catalase+, coagulase, and it is a common inhabitant of skin and oral mucosa. To investigate the spectrum of infections caused by . Read More

BMJ Case Rep 2019 Sep 4;12(9). Epub 2019 Sep 4.

Department of Surgery, Wayne State University, Detroit, Michigan, USA.

A 53-year-old man with dysphagia underwent uneventful placement of a percutaneous endoscopic gastrostomy (PEG) tube for long-term enteral feeding access. 11 hours after the procedure, it was discovered that he had accidentally dislodged the feeding tube. On physical examination, he was found to have a benign abdomen without evidence of peritonitis or sepsis. Read More

Ulus Travma Acil Cerrahi Derg 2019 Aug;25(5):427-432

Department of Emergency Medicine, Urla State Hospital, İzmir-Turkey.

Background: Intra-abdominal adhesions are still a major problem which is expected to be reduced by the provision of bacterial decontamination. Various antibiotics have been used to prevent the formation of adhesion in the septic abdomen. This study aims to investigate the efficacy of ertapenem in sepsis of rats induced by cecal ligation and puncture. Read More

Surg Infect (Larchmt) 2020 Feb 28;21(1):69-74. Epub 2019 Aug 28.

Department of Surgery, University of L'Aquila, San Salvatore Hospital, L'Aquila, Italy.

The grading systems for intra-abdominal sepsis (IAS) are not employed commonly in clinical practice because they are too complicated or too specific. We propose to grade IAS with a simple grading system: the TNM system, which is an acronym borrowed from cancer staging, where T indicates Temperature, N indicates Neutrophils, and M indicates Multiple organ failure (MOF). The aim of this prospective observational study is to assess the predictive value of the TNM score on deaths of patients with complicated IAS. Read More

Med Sci Monit 2019 Aug 23;25:6331-6340. Epub 2019 Aug 23.

Department of Anesthesiology, Lithuanian University of Health Sciences, Kaunas, Lithuania.

BACKGROUND Sepsis is a life-threatening condition with high morbidity and mortality rate. Identifying early prediction factors of critical situations in intra-abdominal sepsis patients can help reduce mortality rates. This prospective study was carried out to evaluate the association of technically available factors with 30-day in-hospital mortality. Read More

Ther Adv Infect Dis 2019 Jan-Dec;6:2049936119865796. Epub 2019 Jul 31.

Department of General Surgery, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.

Background: Secondary peritonitis, following intestinal perforation, constitutes a significant proportion of cases admitted as a surgical emergency and has a mortality rate of 6-21% worldwide. As a part of an antimicrobial stewardship program, we noted considerable variation among the choice of empirical regimens among such cases. Hence, we conducted a prospective study to generate the evidence for a rational empiric regimen for patients with secondary peritonitis following intestinal perforation. Read More

Anal Chem 2019 09 13;91(17):11116-11121. Epub 2019 Aug 13.

Department of Medicine III , University Hospital RWTH Aachen , 52074 Aachen , Germany.

Sepsis constitutes a life-threatening organ failure caused by a deregulated host response to infection. Identifying early biomolecular indicators of organ dysfunction may improve clinical decision-making and outcome of patients. Herein we utilized label-free nonlinear multimodal imaging, combining coherent anti-Stokes Raman scattering (CARS), two-photon excited autofluorescence (TPEF), and second-harmonic generation (SHG) to investigate the consequences of early septic liver injury in a murine model of polymicrobial abdominal infection. Read More

Ann Ital Chir 2019 ;90:258-263

Aim: Laparoscopic lavage /drainage (LALA) or surgical resection are both methods of treatment for perforated diverticulitis with purulent peritonitis (Hinchey Stage III). In case of associated abdominal aortic aneurysm (AAA), laparoscopic lavage/drainage could be an interesting bridge option to treat sepsis before endovascular exclusion of the aneurysm and resection of the sigmoid. We performed LALA as a bridge treatment of peritonitis before elective, staged endovascular exclusion of the aneurysm (EE) and elective resection of the colon. Read More