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Cir Cir 2019 ;87(2):158-163

Clínica de Sepsis Abdominal, Departamento de Cirugía General. Hospital General de México Dr. Eduardo Liceaga, Ciudad de México, México.

Introduction: It is crucial the timely detection of a new infection or the persistence of it to improve the survival rates, there is no index that can determine the need for relaparotomy.

Objective: To evaluate the diagnostic certainty of the model elaborated by Kiewiet-Van Ruler.

Method: A retrospective, descriptive, cross-sectional study, patients diagnosed with abdominal sepsis who underwent exploratory laparotomy between January 2013 to and May 2015. Read More

Eur J Case Rep Intern Med 2017 27;4(2):000501. Epub 2017 Mar 27.

Hospital Egas Moniz, Centro Hospitalar Lisboa Ocidental, Lisbon, Portugal.

Background: Human intestinal spirochetosis is a condition defined by the presence of spirochetes attached to the colonic epithelium. and may cause the disease in humans.

Case Report: We describe the case of a 58-year-old patient who presented with epigastric abdominal pain and diarrhoea. Read More

Int J Surg Case Rep 2019 Feb 1;55:171-173. Epub 2019 Feb 1.

Department of Surgery, College of Health Sciences, University of Nairobi, Kenya.

Introduction: Peptic ulcer perforation is a common surgical emergency that is a complication of 9% of patients with peptic ulcer disease (Kjetil et al., 2015 [1]). Despite advances in the management of peptic ulcer disease, the number of acute complications have remained constant. Read More

Chirurg 2019 Feb 8. Epub 2019 Feb 8.

Klinik für Anästhesiologie, Universitätsklinikum Heidelberg, Heidelberg, Deutschland.

Abdominal sepsis is the most severe form of abdominal infection. It is characterized by a dysregulated host response to infection leading to life-threatening organ failure or septic shock. The latter has a mortality of >40%. Read More

Intensive Care Med Exp 2019 Jan 8;7(1). Epub 2019 Jan 8.

Department of Anaesthesiology, University of Düsseldorf, Moorenstrasse 5, 40225, Düsseldorf, Germany.

Background: Evidence suggests that early adaptive responses of hepatic mitochondria occur in experimentally induced sepsis. Little is known about both colonic mitochondrial function during abdominal infection and long-term changes in mitochondrial function under inflammatory conditions. We hypothesize that hepatic and colonic mitochondrial oxygen consumption changes time-dependently after sterile laparotomy and in the course of abdominal infection. Read More

Saudi J Kidney Dis Transpl 2018 Nov-Dec;29(6):1494-1497

Department of Nephrology, Medical Faculty, Trakya University, Edirne, Turkey.

Serratia marcescens (SM) is an opportunistic Gram-negative bacterium. It can cause technique failure or severe sepsis despite being a rare agent causing peritonitis. We present a case of a 40-year-old woman with end-stage renal disease secondary to chronic glomerulo-nephritis on continuous ambulatory peritoneal dialysis (PD). Read More

J Crit Care Med (Targu Mures) 2018 Oct 1;4(4):120-125. Epub 2018 Oct 1.

University of Medicine, Pharmacy, Sciences and Technology of Târgu Mureş, Târgu Mureş Romania.

Despite the significant development and advancement in antibiotic therapy, life-threatening complication of infective diseases cause hundreds of thousands of deaths world. This paper updates some of the issues regarding the etiology and treatment of abdominal sepsis and summaries the latest guidelines as recommended by the Intra-abdominal Infection (IAI) Consensus (2017). Prognostic scores are currently used to assess the course of peritonitis. Read More

Ulus Travma Acil Cerrahi Derg 2018 Nov;24(6):501-506

Department of General Surgery, Ankara Training and Research Hospital, Ankara-Turkey.

Background: There are varying opinions on the feasibility of the placement of synthetic materials in contaminated surgical fields. The aim of this study was to investigate the outcomes of the use of a commercially available composite mesh in the presence of abdominal infection.

Methods: Twenty-four hours after the induction of experimental peritonitis, 20 rats were randomized into 2 groups of 10 subjects. Read More

Surgery 2018 Nov 10. Epub 2018 Nov 10.

National Center for Global Health and Medicine, Tokyo, Japan.

Background: Whether patients undergoing hemodialysis have greater risks of mortality and morbidity after pancreatoduodenectomy remains unknown.

Methods: We used the Diagnosis Procedure Combination database, a national Japanese inpatient database, to identify patients who underwent pancreatoduodenectomy from July 2010 to March 2015. We conducted propensity-score-matching analyses to compare the outcomes, including postoperative complications and 30- and 90-day mortality after pancreatoduodenectomy between patients with and without hemodialysis. Read More

Forensic Sci Med Pathol 2018 Nov 5. Epub 2018 Nov 5.

Institute of Forensic Medicine "Milovan Milovanović", University of Belgrade - School of Medicine, 31a Deligradska str., Belgrade, 11000, Serbia.

Intussusception is one of the most common causes of intestinal obstructions in younger children, especially infants. Though rare, fatalities due to intussusception are known to be caused by intestinal obstruction associated with peritonitis, generalized sepsis and shock from intestinal infarction due to disruption in blood supply or electrolyte and fluid imbalance. An eight-month-old female infant, who initially presented with a single episode of vomiting and fever (37. Read More

R I Med J (2013) 2018 Nov 1;101(9):32-35. Epub 2018 Nov 1.

Assistant Professor of Medicine, The Warren Alpert Medical School of Brown University, Department of Infectious Diseases, Providence VA Medical Center.

The clinical significance of the relatively avirulent organ- ism, Lactobacillus, has been debated in the past. At times misdiagnosed as a contaminant, Lactobacillus has uncommonly been reported to cause intra-abdominal abscesses, peritonitis, meningitis, bacteremia, pneumonia and endocarditis, especially in the population of patients with underlying comorbid conditions including malignancy, diabetes, recent surgery or organ transplantation. We report a case of a 74-year-old male with Lactobacillus bacteremia leading to prosthetic valve infective endocarditis complicated by an aortic root abscess. Read More

Int J Surg Case Rep 2018 4;53:32-34. Epub 2018 Oct 4.

Department of Anesthesiology and Critical Care Medicine, Burns and Trauma Center, Ben Arous, Tunisia. Electronic address:

Introduction: Necrotizing fasciitis is an uncommon infection characterized by a necrotic infection that rapidly diffuse along the fascia and progresses to systemic sepsis. The combined occurrence of necrotizing fasciitis of the chest wall and acute appendicitis is extremely unusual.

Case Presentation: A 27-year-old man without any significant medical history presented to the emergency department, in the postoperative course of a laparotomy for perforated acute appendicitis, with septic shock and a large erythematous region over the right abdominal wall. Read More

J Vet Emerg Crit Care (San Antonio) 2018 Nov 9;28(6):596-602. Epub 2018 Oct 9.

Department of Clinical Sciences, College of Veterinary Medicine, Auburn University, Auburn, AL 36849.

Objective: To describe the presentation, diagnosis, treatment, and outcome of a case of emphysematous gastritis (EG) in a cat.

Case Series Summary: A 15-year-old female neutered domestic short-hair cat presented for a 4-month history of weight loss and intermittent vomiting. Clinicopathologic and imaging findings suggested an underlying primary gastrointestinal (GI) disease, as well as possible hepatobiliary disease. Read More

Am J Case Rep 2018 Sep 19;19:1113-1116. Epub 2018 Sep 19.

Department of Biomedical Sciences for Health, Division of General Surgery, IRCCS Policlinico San Donato, San Donato Milanese, University of Milan, Milan, Italy.

BACKGROUND Perforated gastric cancer accounts for less than 1% of patients who present with an acute abdomen and for up to 16% of all gastric perforations. A two-stage laparoscopic procedure may be the therapeutic strategy of choice in selected patients, and adjuvant hyperthermic intraperitoneal chemotherapy (HIPEC) can reduce the incidence of peritoneal recurrence. A rare case of subphrenic abscess and gastric perforation due to carcinoma of the gastric fundus, followed by two-stage gastrectomy and adjuvant HIPEC is presented. Read More

Cir Cir 2018 ;86(5):423-427

Clínica de Sepsis, Servicio de Cirugía General. Hospital General de México Dr. Eduardo Liceaga, Ciudad de México, México.

Introducción: La sepsis abdominal representa la respuesta inflamatoria peritoneal ante la invasión microbiana, con una mortalidad del 17%. El índice de peritonitis de Mannheim es una herramienta clínica y un predictor de mortalidad, con alta sensibilidad y especificidad.

Objetivo: Determinar si existe correlación entre el puntaje obtenido mediante el índice de peritonitis de Mannheim y la mortalidad. Read More

Int J Surg Case Rep 2018 20;51:120-124. Epub 2018 Aug 20.

Serviço de Cirurgia Geral do Centro Hospitalar Tondela-Viseu, Avenida Rei D. Duarte, 3504-509, Viseu, Portugal. Electronic address:

Introduction: Acute appendicitis is the main indication for surgery during pregnancy. Physiologic changes during pregnancy and fear of using ionising radiation exams are some of the reasons to delayed diagnosis and consequently to higher morbidity and mortality rates for mother and fetus.

Presentation Of Case: We present the case of a 38-year-old woman that resorted to the emergency room on the 13th week of pregnancy with abdominal discomfort, nausea and vomiting that lasted for 7 days. Read More

Visc Med 2018 Jul 18;34(3):217-223. Epub 2018 Jun 18.

Department of General, Thoracic, Vascular and Transplant Surgery, University Rostock, Rostock, Germany.

Background: The lethality of acute mesenteric ischemia (AMI) remains quite high with 50-70%. The main reasons for that are the fact that AMI is rarely taken into consideration by the differential diagnosis of acute abdomen, the time-consuming diagnostic process, and the lack of a standardized therapeutic concept. The present interdisciplinary review aims to increase awareness among physicians and to help improve clinical outcomes. Read More

Eur Surg Res 2018 8;59(3-4):126-142. Epub 2018 Aug 8.

Department of General, Visceral, Thoracic and Vascular Surgery, Universitätsmedizin Greifswald, Greifswald, Germany.

Background: Magnetic resonance imaging (MRI) techniques are rarely used in the context of abdominal sepsis and in sepsis research. This study investigates the impact of MRI for monitoring septic peritonitis in an animal model (colon ascendens stent-induced peritonitis, CASP). The CASP model closely mimics that of human disease and is highly standardized. Read More

J Indian Assoc Pediatr Surg 2018 Jul-Sep;23(3):115-122

Department of Paediatric Surgery, SMS Medical College, Jaipur, Rajasthan, India.

Context: Pneumoperitoneum is typically a surgical emergency, particularly in neonates. However, pneumoperitoneum can rarely present without gastrointestinal perforation which is known as spontaneous pneumoperitoneum.

Aims: This study aims to analyze the outcome of pediatric patients with spontaneous pneumoperitoneum and describe our experience. Read More

Cureus 2018 May 13;10(5):e2613. Epub 2018 May 13.

Obstetric and Gynaecology, Mahatma Gandhi Medical College and Research Institute, Pondicherry, India.

Stercoral sigmoid perforation is a dangerous surgical emergency. It is also a life-threatening situation because the spillage of fecal contents into the abdominal cavity leads to sepsis with many postoperative complications. Chronic, intermittent constipation can lead to fecal impaction, especially in older patients. Read More

Antimicrob Agents Chemother 2018 Oct 24;62(10). Epub 2018 Sep 24.

INSERM, U1070, UFR de Médecine Pharmacie, Université de Poitiers, TSA 51106, Poitiers, France

The purpose of this study was to investigate aztreonam (ATM) and avibactam (AVI) distribution in intraperitoneal fluid and muscle interstitial fluid by microdialysis in rats, with or without peritonitis, and to compare the unbound concentrations in tissue with the unbound concentrations in blood. Microdialysis probes were inserted into the jugular veins, hind leg muscles, and peritoneal cavities of control rats ( = 5) and rats with intra-abdominal sepsis ( = 9) induced by cecal ligation and punctures. ATM and AVI probe recoveries in each medium were determined for both molecules in each rat by retrodialysis by drug. Read More

Medicine (Baltimore) 2018 Jul;97(28):e11323

Service de réanimation polyvalente.

Rationale: Very few cases of secondary peritonitis caused by Streptococcus pneumoniae have been described in the literature, and they have been found to occur mostly in patients with predisposing factors. Here, we report the case of an elderly patient who developed pneumococcal peritonitis secondary to perforation of gastroduodenal ulcer.

Patient Concerns: An 82-year-old man was admitted to intensive care unit (ICU) for septic shock with cardiac impairment 1 day after arriving in the Emergency Department. Read More

World J Emerg Surg 2018 22;13:26. Epub 2018 Jun 22.

Department of Surgery, Macerata Hospital, Macerata, Italy.

Background: Severe complicated intra-abdominal sepsis (SCIAS) has an increasing incidence with mortality rates over 80% in some settings. Mortality typically results from disruption of the gastrointestinal tract, progressive and self-perpetuating bio-mediator generation, systemic inflammation, and multiple organ failure. Principles of treatment include early antibiotic administration and operative source control. Read More

J Trauma Acute Care Surg 2018 Jul;85(1S Suppl 2):S68-S76

From the Center for Vaccine Development, (M.C., K.A., A.S.C.) University of Maryland School of Medicine, Baltimore, Maryland, Department of Anesthesiology, and Shock, Trauma, and Anesthesiology Research Center (STAR) (P.T., J.L.P., A.M., P.F.S., G.F.), and Department of Pathology (T.C.), University of Maryland School of Medicine, Baltimore, Maryland.

Background: Injured warfighters air evacuated to tertiary medical care facilities are subjected to many stresses that may promote the development of sepsis. In this study, we tested the hypothesis that exposure to "in-flight" hypobaria and/or hyperoxia within 24 hours after onset of intra-abdominal infection in rats accelerates the development and/or severity of sepsis and neurologic injury in survivors.

Methods: Sprague-Dawley rats underwent cecal ligation/puncture (CLP) or sham procedures. Read More

BMJ 2018 06 18;361:k1407. Epub 2018 Jun 18.

Department of Surgery, University of California, San Francisco, San Francisco, CA 94143, USA.

Secondary peritonitis accounts for 1% of urgent or emergent hospital admissions and is the second leading cause of sepsis in patients in intensive care units globally. Overall mortality is 6%, but mortality rises to 35% in patients who develop severe sepsis. Despite the dramatic growth in the availability and use of imaging and laboratory tests, the rapid diagnosis and early management of peritonitis remains a challenge for physicians in emergency medicine, surgery, and critical care. Read More

Int J Surg Case Rep 2018 4;48:131-134. Epub 2018 Jun 4.

Santo André Hospital, Leiria, Portugal.

Introduction: Postoperative duodenal-cutaneous fistula represents a rare and very complex problem. In most cases operative management becomes necessary, but only after local and systemic stabilization and sepsis control.

Case Presentation: A 39-year-old man was admitted for surgical management of laparostomy and pyloro-duodenostomy of the first (DI) and second (DII) duodenal segments with one year of evolution, as a complication of several surgical interventions. Read More

Maedica (Buchar) 2018 Mar;13(1):51-54

Department of Microbiology, MMIMSR Mullana, Ambala Haryana 133207, India.

Objectives: Amoebiasisis a common parasitic infection and fulminant amoebic colitis remains a very rare complication of this disease. The objective of the present study was to find the incidence and outcome of perforation peritonitis due to amoebic colitis in MMIMSR, Mullana, Ambala, India.

Material And Methods: 200 patients with perforation peritonitis were studied retrospectively, out of which 22 cases had colonic perforation, were selected over a period of five years, between 2012 to 2017, at MMIMSR Mullana. Read More

Surg Infect (Larchmt) 2018 May/Jun;19(4):459-466

4 Department of Surgery, Maastricht University Medical Centre , Maastricht, The Netherlands .

Background: This purpose of this study was to investigate the effects of blood stream infections (BSIs) on the prognosis of patients with complicated intra-abdominal infections (IAIs) and to make predictions based on patients' characteristics on admission.

Patients And Methods: One hundred eighty-seven patients with complicated IAI in 2014 and 2015 were included in our retrospective analysis, except for those diagnosed with central line-associated blood stream infections (CLABSIs). Patients with BSIs were compared with patients without BSIs. Read More

Cureus 2018 Mar 1;10(3):e2253. Epub 2018 Mar 1.

Emergency, Osceola Regional Medical Center.

Spontaneous bacterial peritonitis (SBP) has a high mortality rate; early antimicrobial therapy is essential for improving patient outcomes. Given that cirrhotic patients are often coagulopathic, the perceived risk of bleeding may prevent providers from performing a paracentesis and ruling out this potentially deadly disease. We examine the pathophysiology and risk factors for SBP, and current guidelines for its diagnosis and treatment. Read More

Ann Intern Med 2018 May;168(9):ITC65-ITC80

From the University of Washington School of Medicine, Seattle, Washington. (S.M.S., L.L.S.).

Acute colonic diverticulitis is a gastrointestinal condition frequently encountered by primary care practitioners, hospitalists, surgeons, and gastroenterologists. Clinical presentation ranges from mild abdominal pain to peritonitis with sepsis. It can often be diagnosed on the basis of clinical features alone, but imaging is necessary in more severe presentations to rule out such complications as abscess and perforation. Read More

Khirurgiia (Mosk) 2018(4):77-83

Pavlov Ryazan State Medical University of Healthcare Ministry of the Russian Federation, Ryazan, Russia.

The purpose of this study was to determine the effect on the effectiveness of the correction of enteric insufficiency syndrome in patients with urgent surgical pathology included in the scheme of complex therapy Remaxol. The results of complex therapy of 227 patients (98 people with common peritonitis and 129 patients with acute intestinal obstruction) were analyzed. 128 patients of the main group in the postoperative period were included in the therapy scheme Remaxol: intravenously drip in a daily dose of 400 ml at a rate of 40 drops per minute, a course of -5 days. Read More

Case Rep Gastrointest Med 2018 1;2018:5714053. Epub 2018 Mar 1.

Department of Medicine, University of California, San Francisco Medical Center, San Francisco, CA, USA.

species colonize the human gastrointestinal tract and are rarely pathogenic. We present a case involving a cirrhotic patient who presented with sepsis and was found to have peritoneal cultures demonstrating as the sole pathogen concerning for spontaneous bacterial peritonitis. Treatment was achieved with high-dose penicillin and clindamycin but the patient developed hepatorenal syndrome and died from acute renal failure. Read More

Int J Antimicrob Agents 2018 Aug 18;52(2):293-296. Epub 2018 Apr 18.

Infectious Diseases and Intensive Care Unit, Rennes University Hospital, Rennes, France. Electronic address:

Acute appendicitis in children requires early surgery and short-course antibiotics active against Enterobacteriaceae and anaerobes. Although an aminoglycoside-containing three-drug regimen has been used successfully for decades, simpler regimens with similar efficacy are increasingly used. This study evaluated the impact of a switch from the combination of cefotaxime, metronidazole and gentamicin (regimen 1) to piperacillin/tazobactam (regimen 2) as first-line regimen for complicated acute appendicitis in children. Read More

World J Emerg Surg 2018 6;13:17. Epub 2018 Apr 6.

5Department of Surgery, University of Calgary, Calgary, Alberta Canada.

Background: Severe complicated intra-abdominal sepsis (SCIAS) is a worldwide challenge with increasing incidence. Open abdomen management with enhanced clearance of fluid and biomediators from the peritoneum is a potential therapy requiring prospective evaluation. Given the complexity of powering multi-center trials, it is essential to recruit an inception cohort sick enough to benefit from the intervention; otherwise, no effect of a potentially beneficial therapy may be apparent. Read More

Clin Med Insights Case Rep 2018 26;11:1179547618765761. Epub 2018 Mar 26.

Section of Nephrology, Department of Clinical and Experimental Medicine, Policlinico Universitario, University of Catania, Catania, Italy.

Until 2018, 236 cases of acute pancreatitis have been reported in patients who underwent peritoneal dialysis. Here, we presented a patient with double renal transplantation with chronic renal failure, under renal replacement therapy by peritoneal dialysis, who developed acute pancreatitis with abdominal pain, nausea, vomiting, leukocytosis with neutrophil left shift which is complicated by pancreatic pseudocyst, candida peritonitis, fungal sepsis, overlapping of sepsis, and pneumonitis. After the percutaneous cystogastrostomy drainage of pancreatic pseudocyst, changes from peritoneal dialysis to hemodialysis, various thoracentesis, and polyantibiotics therapy, the resolution of the sepsis state was seen. Read More

Surg Infect (Larchmt) 2018 May/Jun;19(4):382-387. Epub 2018 Apr 5.

3 Human Resources for Health , Rwanda .

Background: There is growing recognition of the worsening problem of antibiotic resistance and the need for antibiotic stewardship in low-resource settings. The aim of this study was to describe antibiotic use and antimicrobial resistance in patients undergoing surgery for peritonitis at a Rwandan referral hospital.

Patients And Methods: All surgical patients with peritonitis at a Rwandan referral hospital were enrolled. Read More

Medicine (Baltimore) 2018 Mar;97(13):e9296

Department of Burns and Wound Repair Surgery.

Rationale: Comamonas species are rarely associated with human infections. Recent reports found that Comamonas kerstersii was associated with severe diseases such as abdominal infection and bacteremia. However, C. Read More

Radiol Case Rep 2018 Feb 13;13(1):76-80. Epub 2017 Dec 13.

Division of Abdominal Imaging, Department of Radiology, Temple University Hospital, 3401 N. Broad St., Philadelphia, PA 19140, USA.

Although laparoscopic adjustable gastric banding is considered the most minimally invasive surgical technique for the treatment of morbid obesity, the procedure has a reported overall complication rate of up to 26%. Among the various complications, gastric band erosion with intragastric band migration is the most worrisome because of the risk of subsequent obstruction, peritonitis, and sepsis. Therefore, prompt and accurate diagnosis is crucial during imaging evaluation of these patients in the late postoperative setting. Read More

Rev Gastroenterol Peru 2017 Oct-Dec;37(4):350-356

Universidad Privada del Norte. Lima, Perú.

Iatrogenic bile duct injuries (IBDI) represent a serious surgical complication of laparoscopic cholecystectomy (LC). Often it occurs when the bile duct merges with the cystic duct; and they have been ranked by Strasberg and Bismuth, depending on the degree and level of injury. About third of IBDI recognized during LC, to detect bile leakage. Read More

Medicine (Baltimore) 2017 Dec;96(52):e9434

Department of Pediatrics, Cathay General Hospital, Taipei.

Rationale: Sigmoid volvulus (SV) is an exceptionally rare but potentially life-threatening condition in children.

Chief Complaint: Abdominal distention for 1 week.

Diagnoses: Sigmoid volvulus. Read More

Medicine (Baltimore) 2017 Dec;96(52):e9370

Department of Dermatology.

Rationale: An open abdomen complicated with small-bowel fistulae becomes a complex wound for local infection, systemic sepsis and persistent soiling irritation by intestinal content. While controlling the fistulae drainage, protecting surrounding skin, healing the wound maybe a challenge.

Patient Concerns: In this paper we described a 68-year-old female was admitted to emergency surgery in general surgery department with severe abdomen pain. Read More

Minerva Chir 2018 Apr 23;73(2):188-193. Epub 2018 Jan 23.

Victor Babes University of Medicine and Pharmacy, Timisoara, Romania.

Introduction: Perforations of the peptic ulcers (PPUs) are the most common cause of emergency surgery among the complications of the gastroduodenal ulcers and the leading cause for morbidity and mortality due to secondary peritonitis and sepsis. PPU is a condition in which laparoscopic perforation repair (LPR) is an optimal solution. It makes possible the identification of the perforation's site and allows closure of the perforation and the subsequent peritoneal lavage, as in an open repair (OR) but without the large upper mid-abdominal incision. Read More

Korean J Gastroenterol 2018 01;71(1):45-48

Department of Internal Medicine, Seoul Paik Hospital, Inje University College of Medicine, Seoul, Korea.

Gas-forming pyogenic liver abscess (GFPLA) is very rare and has a very high mortality in case of rupture into the abdominal cavity, which usually require surgical treatment. We experienced a case of a ruptured GFPLA due to complicated with peritonitis and sepsis in a 68-year-old diabetic woman. Immediate and aggressive medical treatments including intravenous antibiotics, percutaneous drainage, and continuous renal replacement therapy dramatically improved the liver abscess, peritonitis, and metabolic problems. Read More

J Pediatr Surg 2018 Apr 5;53(4):676-681. Epub 2017 Dec 5.

Department of pediatric general surgery, Children's Hospital, Zhejiang University School of Medicine, No. 57 Zhugan Street, Xiacheng District, Hangzhou, P.R. China 310000. Electronic address:

Purpose/background: Meckel's diverticulum (MD) is one of the most common congenital malformations of gastrointestinal tract in children. However, the nonspecific clinical manifestations of MD often cause a diagnostic as well as therapeutic challenge to pediatric surgeon. This study aimed to review our experience in managing this disease while evaluating the management strategies. Read More

Intern Med J 2018 01;48(1):100-101

Department of Infectious Diseases and Microbiology, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia.

Int J Surg Case Rep 2018 7;42:94-97. Epub 2017 Dec 7.

Department of General Surgery, Raleigh General Hospital, Beckley, WV, United States.

Introduction: Stercoral perforation of the colon is a rare pathology, which is believed to be caused by an increased intraluminal pressure created by a fecaloma. Opioid induced constipation is a rare and often unsuspected cause of colonic perforation.

Presentation Of Case: We report the case of a 58-year-old woman, who presented to the emergency department (ED) with severe hypotension, abdominal pain and gastrointestinal bleeding. Read More

World J Surg 2018 06;42(6):1679-1686

General and Emergency Surgery - Policlinico P. Giaccone, University of Palermo, Via Liborio Giuffré 5, 90127, Palermo, Italy.

Background: Open abdomen (OA) permits the application of damage control surgery principles when abdominal trauma, sepsis, severe acute peritonitis and abdominal compartmental syndrome (ACS) occur.

Methods: Non-traumatic patients treated with OA between January 2010 and December 2015 were identified in a prospective database, and the data collected were retrospectively reviewed. Patients' records were collected from charts and the surgical and intensive care unit (ICU) registries. Read More

J Immunol 2017 12 27;199(11):3914-3924. Epub 2017 Oct 27.

INSERM U1016, Institut Cochin, 75014 Paris, France;

Proteinase 3 (PR3) is a myeloid serine protease expressed in neutrophils, monocytes, and macrophages. PR3 has a number of well-characterized proinflammatory functions, including cleaving and activating chemokines and controlling cell survival and proliferation. When presented on the surface of apoptotic neutrophils, PR3 can disrupt the normal anti-inflammatory reprogramming of macrophages following the phagocytosis of apoptotic cells. Read More