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J Surg Oncol 2021 May 7. Epub 2021 May 7.

Westat, Rockville, Maryland, USA.

Background: In the management of peritoneal metastases from colon and rectal cancer, the most favorable results are reported with an aggressive combined treatment on patients who have a small extent of the disease. A test to detect occult peritoneal metastases would greatly facilitate the management of this component of colorectal dissemination.

Methods: Currently, the standard test by which to confirm the diagnosis of the peritoneal spread of colorectal cancer is peritoneal cytology. Read More

Ann Surg Oncol 2021 May 6. Epub 2021 May 6.

Department of Surgery, University of Chicago, Chicago, IL, USA.

Background: Cytoreductive surgery (CRS) for ovarian cancer with peritoneal metastases (OPM) is an established treatment, yet access-related racial and socioeconomic disparities are well documented. CRS for colorectal cancer with peritoneal metastases (CRPM) is garnering more widespread acceptance, and it is unknown what disparities exist with regards to access.

Methods: This retrospective cross-sectional multicenter study analyzed medical records from the National Cancer Database from 2010 to 2015. Read More

JAMA Oncol 2021 May 6. Epub 2021 May 6.

Center for Gynecologic Oncology Amsterdam, The Netherlands Cancer Institute, Amsterdam.

Importance: The peritoneal surface is a common site of disease in ovarian and colorectal cancer. Peritoneal metastases carry a poor prognosis, despite maximal therapeutic efforts, including surgical removal of tumor deposits and intravenous chemotherapy. Hyperthermic intraperitoneal chemotherapy (HIPEC) is a single intraoperative procedure that delivers chemotherapy directly into the abdominal cavity, leading to high intracellular drug concentration at the peritoneal surface. Read More

Urol Int 2021 May 5:1-8. Epub 2021 May 5.

Department of Urology, Uro-Oncology, Robot-assisted and Specialized Urologic Surgery, Cologne University Hospital, Cologne, Germany.

Introduction: Symptomatic lymphoceles (SLs) represent the most common complication after radical prostatectomy (RP) and pelvic lymph node dissection (PLND). To date, preoperative risk factors are missing.

Methods: Clinical and pathological data of 592 patients who underwent RP and PLND were evaluated. Read More

Pol Przegl Chir 2021 Feb;93(2):1-8

Ankara University School of Medicine, Department of Surgical Oncology.

AİM Staging laparoscopy enables us to perform palliative treatment, neo-adjuvant therapy for curative resection or direct curative resection and making a decision with minimal morbidity by avoiding from unnecessary laparotomies. In the present study, the importance of staging lapafoscopy was retrospectively investigated by using clinical and pathologic data. METHODS Data of 70 out of 350 patients who underwent diagnostic laparoscopy due to gastric cancer at Surgical Oncology department between August 2013 and January 2020 were retrospectively analyzed. Read More

Eur Radiol 2021 May 4. Epub 2021 May 4.

Radiology Department, Shanxi Medical University Second Affiliated Hospital, Taiyuan, 030001, Shanxi, China.

Objectives: To develop a radiomics signature based on multisequence magnetic resonance imaging (MRI) to preoperatively predict peritoneal metastasis (PM) in ovarian cancer (OC).

Methods: Eighty-nine patients with OC were divided into a training cohort including patients (n = 54) with a single lesion and a validation cohort including patients (n = 35) with bilateral lesions. Radiomics features were extracted from the T2-weighted images (T2WIs), fat-suppressed T2WIs, multi-b-value diffusion-weighted images (DWIs), and corresponding parametric maps. Read More

Pharmaceutics 2021 Apr 29;13(5). Epub 2021 Apr 29.

Oncoinvent AS, 0484 Oslo, Norway.

Radium-224-labeled CaCO microparticles have been developed to treat peritoneal carcinomatosis. The microparticles function as carriers of Ra, facilitating intraperitoneal retention of the alpha-emitting radionuclide. It was necessary to control the size of microparticles in suspension over time and introduce a sterilization process for the clinical use of the radiopharmaceutical. Read More

Diagn Cytopathol 2021 May 4. Epub 2021 May 4.

Department of Pathology, Wake Forest Baptist Health, Winston-Salem, North Carolina, USA.

Histiocytes containing multiple needle-shaped eosinophilic crystals visualized in a peritoneal fluid sample during evaluation of a patient for liver transplantation led to the diagnosis of unsuspected IgA kappa myeloma. Crystal-storing histiocytosis is a rare phenomenon typically associated with multiple myeloma and B-cell lymphoproliferative disorders. It can involve almost any anatomic site and can occasionally be seen in body fluid samples. Read More

Ann Surg Oncol 2021 May 3. Epub 2021 May 3.

Westat, Rockville, MD, USA.

Background: Malignant peritoneal mesothelioma is a rare and often fatal disease. Dissemination is confined to the abdominal and pelvic peritoneal spaces in a great majority of patients.

Methods: Standardized cytoreductive surgery and perioperative chemotherapy was used in all patients. Read More

BMJ Support Palliat Care 2021 May 3. Epub 2021 May 3.

Department of Gynaecology and Obstetrics, Aarhus University Hospital, Aarhus, Denmark.

Objective: When intended curative cancer surgery is not completed, the postoperative transition to palliative care represents a prognostic landmark to patients and their families. In patients referred for highly specialised surgery for peritoneal metastases from the intestinal tract and ovaries, surgery is not performed in approximately 25%. Still, little is known of their postoperative needs and preferences. Read More

Biochem Biophys Res Commun 2021 Apr 30;559:121-128. Epub 2021 Apr 30.

Department of Gynecology and Obstetrics, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, 200092, China. Electronic address:

Nucleolar protein 4-like (NOL4L) was first identified in acute myeloid leukaemia. Then, it was verified to be involved in cell progression in neuroblastoma. However, the functional role of NOL4L in tumor proliferation and metastasis and the underlying molecular mechanism(s) are not fully understood. Read More

ESMO Open 2021 Apr 30;6(3):100132. Epub 2021 Apr 30.

Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA. Electronic address:

Background: Metastatic small bowel adenocarcinoma (SBA) has a poor prognosis. Due to its rarity, high-quality data are lacking to guide treatment. This retrospective analysis was conducted to help characterize the treatment options for patients with metastatic SBA while providing clinically meaningful prognostic information. Read More

J Cell Mol Med 2021 May 3. Epub 2021 May 3.

Department of Surgery, Indiana University School of Medicine, South Bend, IN, USA.

Elevated expression of multiple growth factors and receptors including c-Met and VEGFR has been reported in gastric adenocarcinoma (GAC) and thus provides a potentially useful therapeutic target. The therapeutic efficacy of foretinib, a c-Met/VEGFR2 inhibitor, was determined in combination with nanoparticle paclitaxel (NPT) in GAC. Animal studies were conducted in NOD/SCID mice in subcutaneous and peritoneal dissemination xenografts. Read More

Iran J Pathol 2021 21;16(2):227-231. Epub 2020 Dec 21.

Radiation Oncology Research Center (RORC), Cancer Research Institute, Tehran University of Medical Sciences, Tehran, Iran.

Mesonephric adenocarcinoma of the uterine cervix is an extremely rare tumor of the female genital tract which derives from the remnants of embryonic mesonephric ducts and its prognosis, diagnosis and treatment is rather challenging. We report a case of a 46-year-old woman with history of abnormal uterine bleeding and an enlarged uterine cervix on physical examination without obvious mass lesion. She was clinically underdiagnosed with cervical myoma and mesonephric hyperplasia. Read More

Front Immunol 2021 14;12:663379. Epub 2021 Apr 14.

Division of Hematology-Oncology, Massachusetts General Hospital, Boston, MA, United States.

Immunotherapy for ovarian cancer is an area of intense investigation since the majority of women with relapsed disease develop resistance to conventional cytotoxic therapy. The paucity of safe and validated target antigens has limited the development of clinically relevant antibody-based immunotherapeutics for this disease. Although MUC16 expression is almost universal in High Grade Serous Ovarian Cancers, engagement of the shed circulating MUC16 antigen (CA-125) presents a theoretical risk of systemic activation and toxicity. Read More

Eur J Surg Oncol 2021 Apr 20. Epub 2021 Apr 20.

Department of Surgical Oncology, The Institute for Cancer Care, Mercy Medical Center 227 St. Paul Place, 4th Floor Weinberg, Baltimore, MD, 21202-2001, USA. Electronic address:

Introduction: Genital necrosis (GN) is a rare complication of cytoreductive surgery with hyperthermic intraoperative chemotherapy (CRS/HIPEC) which can be confused with necrotizing fasciitis. We present an analysis of GN after CRS/HIPEC to define its natural history.

Methods: We identified patients with GN after CRS/HIPEC at two peritoneal surface malignancy institutions. Read More

Lancet Oncol 2021 05;22(5):e179-e180

Department of Digestive Surgery Hôpital Saint Louis, Paris, France.

Lancet Oncol 2021 05;22(5):e178

Department of Abdominal, Tumor, Transplant and Vascular Surgery, Merheim Medical Center Cologne, Witten/Herdecke University, Cologne 51109, Germany.

Lancet Oncol 2021 05;22(5):e177

Department of Surgical Sciences, Uppsala University Hospital, Uppsala 75185, Sweden. Electronic address:

Lancet Oncol 2021 05;22(5):e176

Peritoneal Tumours Unit, IRCCS Regina Elena National Cancer Institute, Rome 00144, Italy.

Lancet Oncol 2021 05;22(5):e175

Department of Surgical Oncology, Tata Memorial Hospital, Mumbai, India.

Lancet Oncol 2021 05;22(5):e174

Department of Surgery, Catharina Cancer Institute, Eindhoven, 5602 ZA, Netherlands; GROW-School for Oncology and Developmental Biology, Maastricht University, Maastricht, Netherlands. Electronic address:

Eur J Surg Oncol 2021 Apr 21. Epub 2021 Apr 21.

Department of Gastroenterological Surgery, Gastroenterological Center, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan.

Introduction: After curative gastrectomy followed by 1-year adjuvant S-1 monotherapy for pathological stage (pStage) II or III gastric cancer, some patients experience peritoneal, hematogenous, or lymph nodal recurrence. However, risk factors for each recurrence pattern despite completed adjuvant S-1 monotherapy remain unclear. The aim of this study was to determine which factors influence each recurrence type after curative gastrectomy followed by 1-year adjuvant S-1 monotherapy. Read More

Biosens Bioelectron 2021 Apr 22;185:113265. Epub 2021 Apr 22.

Biosensor National Special Laboratory, Key Laboratory for Biomedical Engineering of Education Ministry, Department of Biomedical Engineering, Zhejiang University, Hangzhou, 310027, PR China. Electronic address:

As a severe stage of cancers, peritoneal carcinomatosis should be frequently monitored by means of ascites analysis. Nevertheless, the analysis process is traumatic and time-consuming in clinical practice. In this study, an implantable platinum nanotree microelectrode with a wireless, battery-free and flexible electrochemical patch was developed for in vivo and real-time peritoneal glucose detection to monitor peritoneal carcinomatosis. Read More

PLoS One 2021 30;16(4):e0250726. Epub 2021 Apr 30.

Department of Surgery, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States of America.

Background: We hypothesize that women undergoing cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) for peritoneal carcinomatosis from appendiceal cancer will have a survival advantage compared to men.

Methods: The National Cancer Database (NCDB) public user file (2004-2014) was used to select patients with PC undergoing CRS and HIPEC from appendiceal cancer. Univariate and multivariable analyses were performed. Read More

Front Oncol 2021 13;11:610885. Epub 2021 Apr 13.

Cell Signaling and Metabolism Networks Program, Division of Oncology, Department of Medicine I, Medical University of Vienna, Vienna, Austria.

Ovarian cancer(OC) is a serious threat to women worldwide. Peritoneal dissemination, ascites and omental metastasis are typical features for disease progression, which occurs in a micro-environment that is rich in high-energy lipids. OC cells require high amounts of lipids for survival and growth. Read More

Front Pharmacol 2021 13;12:659258. Epub 2021 Apr 13.

Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, China.

5-fluorouracil (5-FU) is basically used in the field of postoperative chemotherapy of gastric cancer (GC), the goal of this study was to evaluate improvement of long-term survival rate among GC patients after the 5-FU implants treatment. The study included 145 patients with gastric cancer who received postoperative chemotherapy with 5-FU implants and had complete follow-up information. According to the sex, age and clinical stage of 5-FU implants group, 74 patients were matched as the control group at the same time. Read More

J Clin Med 2021 Apr 28;10(9). Epub 2021 Apr 28.

Washington (D.C.) Cancer Institute at Washington Hospital Center, Washington, DC 20007, USA.

Common knowledge would suggest that regional treatments for peritoneal metastases from gastric cancer would not be successful [... Read More

Cancers (Basel) 2021 Apr 13;13(8). Epub 2021 Apr 13.

Center for Gastric Cancer, National Cancer Center, 323 Ilsan-ro, Goyang 10408, Korea.

Recently, nonexposure simple suturing endoscopic full-thickness resection (NESS-EFTR) method was developed to avoid tumor exposure to the peritoneal cavity. The aim of this study is to compare the short-term outcomes of the NESS-EFTR method with those of laparoscopic and endoscopic cooperative surgery (LECS) for gastric subepithelial tumors (SETs). A prospective single-center trial of LECS for gastric SETs was performed from March 2012 to October 2013 with a separate prospective trial of NESS-EFTR performed from August 2015 to June 2017, enrolling 15 patients each. Read More

Int J Mol Sci 2021 Apr 23;22(9). Epub 2021 Apr 23.

Department of Medical Imaging, University of Pécs Medical School, 7624 Pécs, Hungary.

Bc-DLFL.1 is a novel spontaneous, high-grade transplantable mouse B-cell lymphoma model for selective serosal propagation. These cells attach to the omentum and mesentery and show dissemination in mesenteric lymph nodes. Read More