39,868 results match your criteria Peritoneal Cancer


Neutrophils Derived from Genetically Modified Human Induced Pluripotent Stem Cells Circulate and Phagocytose Bacteria In Vivo.

Stem Cells Transl Med 2019 Feb 21. Epub 2019 Feb 21.

Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.

Bacterial and fungal infections are a major cause of morbidity and mortality in neutropenic patients. Donor derived neutrophil transfusions have been used for prophylaxis or treatment for infection in neutropenic patients. However, the short half-life and the limited availability of large numbers of donor derived neutrophils for transfusion remain a significant hurdle in the implementation of neutrophil transfusion therapy. Read More

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http://dx.doi.org/10.1002/sctm.18-0255DOI Listing
February 2019

A single-institution retrospective analysis of gastric carcinoma with positive peritoneal lavage cytology and without serosal invasion: A case series.

Ann Med Surg (Lond) 2019 Mar 30;39:10-15. Epub 2019 Jan 30.

Department of Surgery, Jichi Medical University, Tochigi, Japan.

Background And Objectives: Peritoneal dissemination of gastric cancer is often associated with serosal infiltration. The aim of this study was to evaluate the clinical importance of peritoneal lavage cytology in patients with gastric carcinoma without serosal invasion. The incidence and impact on prognosis of positive cytology were analyzed. Read More

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http://dx.doi.org/10.1016/j.amsu.2019.01.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370578PMC

[Surgery for advanced stage ovarian cancer: Article drafted from the French Guidelines in oncology entitled "Initial management of patients with epithelial ovarian cancer" developed by FRANCOGYN, CNGOF, SFOG, GINECO-ARCAGY under the aegis of CNGOF and endorsed by INCa].

Gynecol Obstet Fertil Senol 2019 Feb 18. Epub 2019 Feb 18.

IMRB, U955 Inserm, service de gynécologie obstétrique et médecine de la reproduction, centre hospitalier intercommunal de Créteil, institut Mondor de recherche biomédicale, 94000 Créteil, France. Electronic address:

Debulking surgery is the key step of advanced stage ovarian cancer treatment with chemotherapy. The quality of surgical resection is the main prognosis factor, thus a complete resection must be achieved (grade A) in an expert center (grade B). Surgery for stage IV is possible and has a benefit in case of complete peritoneal resection (LoE3). Read More

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http://dx.doi.org/10.1016/j.gofs.2019.01.003DOI Listing
February 2019

Strategy for treatment of stage IV human epidermal growth factor 2-positive gastric cancer: a case report.

J Med Case Rep 2019 Feb 22;13(1):42. Epub 2019 Feb 22.

Department of Surgery, Osaka Red Cross Hospital, 5-30 Fudegasakicho, Tennoji Ward, Osaka, 543-8555, Japan.

Background: The prognosis of stage IV gastric cancer and human epidermal growth factor 2 (HER2)-positive gastric cancer is poor, although new drugs and regimens have been developed. We report a case of a patient with stage IV HER2-positive gastric cancer treated successfully by conversion therapy and trastuzumab.

Case Presentation: The patient was a 73-year-old Japanese man diagnosed as L, type 3, circ, T4aNxCy1P1M1, stage IV (the Japanese classification of gastric carcinoma). Read More

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http://dx.doi.org/10.1186/s13256-019-2001-3DOI Listing
February 2019

Strengthening the AntiTumor NK Cell Function for the Treatment of Ovarian Cancer.

Int J Mol Sci 2019 Feb 19;20(4). Epub 2019 Feb 19.

Department of Experimental Medicine (DIMES) and Centre of Excellence for Biomedical Research (CEBR), University of Genoa, 16132 Genoa, Italy.

The crosstalk between cancer cells and host cells is a crucial prerequisite for tumor growth and progression. The cells from both the innate and adaptive immune systems enter into a perverse relationship with tumor cells to create a tumor-promoting and immunosuppressive tumor microenvironment (TME). Epithelial ovarian cancer (EOC), the most lethal of all gynecological malignancies, is characterized by a unique TME that paves the way to the formation of metastasis and mediates therapy resistance through the deregulation of immune surveillance. Read More

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http://dx.doi.org/10.3390/ijms20040890DOI Listing
February 2019

SPHK1-induced autophagy in peritoneal mesothelial cell enhances gastric cancer peritoneal dissemination.

Cancer Med 2019 Feb 21. Epub 2019 Feb 21.

Department of Surgical Oncology, First Affiliated Hospital of China Medical University, Shenyang, China.

Gastric cancer peritoneal dissemination (GCPD) has been recognized as the most common form of metastasis in advanced gastric cancer (GC), and the survival is pessimistic. The injury of mesothelial cells plays an important role in GCPD. However, its molecular mechanism is not entirely clear. Read More

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http://dx.doi.org/10.1002/cam4.2041DOI Listing
February 2019

Patterns of referral and uptake of BReast CAncer (BRCA) gene testing of eligible women with ovarian cancer in New Zealand.

N Z Med J 2019 Feb 22;132(1490):26-35. Epub 2019 Feb 22.

Senior Lecturer, Department of Obstetrics & Gynaecology, University of Otago, Christchurch & Gynaecological Oncologist, Christchurch Women's Hospital, Christchurch.

Aims: To determine the proportion of eligible patients with high-grade serous carcinoma of the ovary, fallopian tube or peritoneum discussed at gynaecological oncology multidisciplinary meetings (MDMs) in New Zealand and subsequently referred for genetic counselling and BRCA pathogenic variant testing.

Methods: Eligible cases were identified from Auckland, Wellington, Christchurch and Dunedin gynaecologic oncology MDM databases between 1 January 2015 to 31 December 2016. Patients who met the eligibility criteria for genetics referral were identified, and cross-referenced against genetic services databases to ascertain the rates of referrals received, the numbers attending appointments, genetic testing offered and range of results. Read More

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February 2019

Imaging strategies in the management of gastric cancer: current role and future potential of MRI.

Br J Radiol 2019 Feb 21:20181044. Epub 2019 Feb 21.

1 Department of Surgery, University Medical Center Utrecht, Utrecht University , Utrecht , Netherlands.

Accurate preoperative staging of gastric cancer and the assessment of tumor response to neoadjuvant treatment is of importance for treatment and prognosis. Current imaging techniques, mainly endoscopic ultrasonography (EUS), computed tomography (CT) and F-fluorodeoxyglucose positron emission tomography (F-FDG PET), have their limitations. Historically, the role of magnetic resonance imaging (MRI) in gastric cancer has been limited, but with the continuous technical improvements, MRI has become a more potent imaging technique for gastrointestinal malignancies. Read More

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http://dx.doi.org/10.1259/bjr.20181044DOI Listing
February 2019

The use of cisplatin plus doxorubicin or paclitaxel in hyperthermic intraperitoneal chemotherapy (HIPEC) for stage IIIC or IV epithelial ovarian cancer: a comparative study.

Clin Transl Oncol 2019 Feb 20. Epub 2019 Feb 20.

Department of Medical Oncology, University Hospital of Fuenlabrada, C/Camino del Molino 2, 28942, Fuenlabrada, Madrid, Spain.

Purpose: Our main aim is to analyze the survival results in women operated on for advanced ovarian cancer with two different HIPEC regimens (cisplatin plus doxorubicin versus paclitaxel).

Patients And Methods: A prospective cohort of patients with stage IIIC or IV epithelial ovarian cancer operated on with cytoreductive surgery and HIPEC, from October-2008 to February-2016, was retrospectively analyzed. The two drugs used, cisplatin/doxorubicin (Group A) and paclitaxel (Group B), were compared. Read More

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http://dx.doi.org/10.1007/s12094-019-02065-3DOI Listing
February 2019

Extended abdominopelvic MRI versus CT at the time of adnexal mass characterization for assessing radiologic peritoneal cancer index (PCI) prior to cytoreductive surgery.

Abdom Radiol (NY) 2019 Feb 20. Epub 2019 Feb 20.

Department of Surgical Oncology, Oncology Center Mansoura University, Mansoura, Egypt.

Purpose: To evaluate whether extending the MRI scan to include the abdomen at the time of adnexal mass characterization could replace additional CT for peritoneal cancer index (PCI) assessment.

Methods: After institutional review board approval for this prospective study, 36 consecutive females with ovarian and FT malignancies were included. All patients signed an informed consent. Read More

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http://dx.doi.org/10.1007/s00261-019-01939-yDOI Listing
February 2019

TAS0728, a covalent-binding, HER2-selective kinase inhibitor shows potent antitumor activity in preclinical models.

Mol Cancer Ther 2019 Feb 20. Epub 2019 Feb 20.

Discovery and Preclinical Research Division, Taiho Pharmaceutical Co., Ltd.

Activated human epidermal growth receptor (HER) 2 is a promising therapeutic target for various cancers. Although several reports have described HER2 inhibitors in development, no covalent-binding inhibitor selective for HER2 has been reported. Here, we report a novel compound, TAS0728 that covalently binds to HER2 at C805 and selectively inhibits its kinase activity. Read More

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http://dx.doi.org/10.1158/1535-7163.MCT-18-1085DOI Listing
February 2019

Sexual dimorphism of acute doxorubicin-induced nephrotoxicity in C57Bl/6 mice.

PLoS One 2019 20;14(2):e0212486. Epub 2019 Feb 20.

Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota, United States of America.

Doxorubicin (DOX) is a chemotherapeutic agent that has been reported to cause nephrotoxicity in rodent models and to a lesser degree in cancer patients. Female rodents have been shown to be protected against several features of DOX-induced nephrotoxicity. Nevertheless, the underlying mechanisms of this sexual dimorphism are not fully elucidated. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212486PLOS
February 2019

DIGESTIVE DISEASES IN ELDERLY AND FACTORS ASSOCIATED WITH LENGTH OF STAY IN THE HEPATOLOGY AND GASTROENTEROLOGY UNIT OF THE CAMPUS TEACHING HOSPITAL OF LOME (TOGO).

Arq Gastroenterol 2018 Oct-Dec;55(4):369-374

Hepatology and Gastroenterology Unit of the Campus Teaching Hospital of Lome, Togo.

Background: The digestive pathologies are frequent in the elderly and often have a latent and atypical symptomatology.

Objective: To assess the epidemiological and evolutionary current data on digestive diseases in the elderly, and look for factors associated with length of hospital stay.

Methods: Retrospective study of 10 years, including patients aged 60 and over hospitalized for digestive diseases in the Gastroenterology Department of the Campus Teaching Hospital of Lome, Togo. Read More

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http://dx.doi.org/10.1590/S0004-2803.201800000-80DOI Listing

Executive summary for the 2015 Annual Data Report of the China Kidney Disease Network (CK-NET).

Kidney Int 2019 Mar;95(3):501-505

Renal Division, Department of Medicine, Peking University First Hospital, Peking University Institute of Nephrology, Beijing, China; Peking-Tsinghua Center for Life Sciences, Beijing, China.

Chronic kidney disease (CKD) has received increased attention as a leading public health problem worldwide. Globally surveillance systems for kidney disease are still lacking, especially in developing countries like China, which constitutes an obstacle to develop effective preventive strategies. China Kidney Disease Network (CK-NET) was initiated in 2014 and further developed in accordance with the national strategy of prompting Big Data application in China. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00852538183081
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http://dx.doi.org/10.1016/j.kint.2018.11.011DOI Listing
March 2019
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High expression of MUC20 drives tumorigenesis and predicts poor survival in endometrial cancer.

J Cell Biochem 2019 Feb 19. Epub 2019 Feb 19.

Department of Gynecology, Ningbo No. 2 Hospital, Ningbo, Zhejiang, China.

Mucins (MUCs) have been reported to play a critical role in the tumorigenesis of different cancers. This study was performed to explore the effect of MUC20 in endometrial cancer (EC). A total of 541 patients with EC were examined from The Cancer Genome Atlas. Read More

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http://dx.doi.org/10.1002/jcb.28466DOI Listing
February 2019

Exploring the added value of hospital-registry data for showing local service outcomes: cancers of the ovary, fallopian tube and peritoneum.

BMJ Open 2019 Feb 19;9(2):e024036. Epub 2019 Feb 19.

Royal Adelaide Hospital, Adelaide, South Australia, Australia.

Objectives: To explore the added value of hospital-registry data on invasive epithelial ovarian, tubal and peritoneal cancers.

Design: Historic cohort analyses.

Methods: Unadjusted and adjusted regression. Read More

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http://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2018-02403
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http://dx.doi.org/10.1136/bmjopen-2018-024036DOI Listing
February 2019
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Therapeutic Approaches of Resveratrol on Endometriosis via Anti-Inflammatory and Anti-Angiogenic Pathways.

Molecules 2019 Feb 13;24(4). Epub 2019 Feb 13.

Department of Medical and Surgical Specialties, Faculty of Medicine, Transilvania University of Brasov, 500019 Brasov, Romania.

Endometriosis represents a severe gynecological pathology, defined by implantation of endometrial glands and stroma outside the uterine cavity. This pathology affects almost 15% of women during reproductive age and has a wide range of consequences. In affected women, infertility has a 30% rate of prevalence and endometriosis implants increase the risk of ovarian cancer. Read More

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http://dx.doi.org/10.3390/molecules24040667DOI Listing
February 2019

Immune-enhancing effects of anionic macromolecules extracted from Codium fragile on cyclophosphamide-treated mice.

PLoS One 2019 19;14(2):e0211570. Epub 2019 Feb 19.

Department of Marine Food Science and Technology, Gangneung-Wonju National University, Gangneung, Gangwon, Korea.

Immune-regulation and homeostasis are critical in cancer therapy and immunomodulatory biomaterials have been used to decrease side effects of immunosuppressant drugs. Anionic macromolecules (CFAMs) were isolated from the seaweed Codium fragile, and its immune-enhancing biological activities were examined in CY-induced immunosuppressed mice. CFAMs improved the splenic lymphocyte proliferation, NK cell activity, and spleen index. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211570PLOS
February 2019

Oncostatin M receptor, positively regulated by SP1, promotes gastric cancer growth and metastasis upon treatment with Oncostatin M.

Gastric Cancer 2019 Feb 18. Epub 2019 Feb 18.

Shanghai Key Laboratory of Gastric Neoplasms, Shanghai Institute of Digestive Surgery, Department of Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.

Background: Oncostatin M receptor (OSMR) is a member of the interleukin 6 (IL-6) receptor family that transduces signaling events of Oncostatin M (OSM). OSM-OSMR signaling plays a key role in inflammation and cancer progression. However, the role of OSM-OSMR in gastric cancer (GC) is still unknown. Read More

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http://dx.doi.org/10.1007/s10120-019-00934-yDOI Listing
February 2019

BAP1 haploinsufficiency predicts a distinct immunogenic class of malignant peritoneal mesothelioma.

Genome Med 2019 Feb 18;11(1). Epub 2019 Feb 18.

Vancouver Prostate Centre, 2660 Oak St, Vancouver, BC, V6H 3Z6, Canada.

Background: Malignant peritoneal mesothelioma (PeM) is a rare and fatal cancer that originates from the peritoneal lining of the abdomen. Standard treatment of PeM is limited to cytoreductive surgery and/or chemotherapy, and no effective targeted therapies for PeM exist. Some immune checkpoint inhibitor studies of mesothelioma have found positivity to be associated with a worse prognosis. Read More

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http://dx.doi.org/10.1186/s13073-019-0620-3DOI Listing
February 2019

Revised management of advanced primary colon cancer: Case series of 2 patients.

Int J Surg Case Rep 2019 Feb 10;55:233-238. Epub 2019 Feb 10.

Department of Surgery, MedStar Washington Hospital Center, Washington, DC, USA.

Background: The resection of a primary colon cancer has the opportunity to cure the patient of cancer by complete clearance and absolute containment of disease. Alternatively, if the cancer resection does not provide clearance and containment it will eventuate in local recurrence and peritoneal dissemination.

Methods: Culpability of recurrence of colorectal cancer is difficult to determine. Read More

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http://dx.doi.org/10.1016/j.ijscr.2019.01.046DOI Listing
February 2019

Endometriosis-associated ovarian cancer: What have we learned so far?

Clin Chim Acta 2019 Feb 15. Epub 2019 Feb 15.

Division of Laboratory Medicine, Asia University Hospital, Asia University, Taichung, Taiwan; Deparment of Food Nutrition and Health Biotechnology, Asia University, Taichung, Taiwan; Deparment of Post-Baccalaureate Veterinary Medicine, Asia University, Taichung, Taiwan; Deparment of Nursing, Asia University, Taichung, Taiwan. Electronic address:

Endometriosis is defined as the presence of ectopic endometrial tissue outside of the uterine cavity, most commonly in the ovaries and peritoneum. It is a complex disease that is influenced by multiple factors. It is also a common gynecological disorder and affects approximately 10-15% of all women of reproductive age. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00098981193006
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http://dx.doi.org/10.1016/j.cca.2019.02.016DOI Listing
February 2019
4 Reads

A proposal for updating the staging of endometrial cancer.

Int J Gynaecol Obstet 2019 Feb 18. Epub 2019 Feb 18.

Department of Pathology, Autonomous University of Barcelona, Barcelona, Spain.

Since the last update of the International Federation of Gynecology and Obstetrics (FIGO) staging for corpus uteri cancer in 2009, a number of new insights into pathology, molecular genetics, and prognostic factors that justify a revision have been made. We recommend incorporation of histotype and grade along with depth of myometrial invasion to define stage I endometrial cancer, a change from 3-tier grading to binary grading, and inclusion of lymph node status (negative versus not removed) in the definition of stage I disease. Elimination of cervical involvement to define stage II and inclusion of positive peritoneal cytology to upstage otherwise stage I cancers to stage IIA is also recommended. Read More

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http://dx.doi.org/10.1002/ijgo.12789DOI Listing
February 2019

Evaluation of screening and risk-reducing surgery for women followed in a high-risk breast/ovarian cancer clinic: it is all about the tubes in BRCA mutation carriers.

Gynecol Oncol Rep 2019 May 1;28:18-22. Epub 2019 Feb 1.

Division of Gynecologic Oncology, Department of Obstetrics & Gynecology, University of Virginia Health System, Charlottesville, VA, USA.

The objectives of this study were to determine both surgical and subsequent cancer outcomes for high-risk women from the University of Virginia's High-Risk Breast/Ovarian Cancer clinic undergoing ovarian cancer risk-reducing surgery. Retrospective review identified high risk women who had ovarian risk reducing surgery over the past decade and surgical outcomes, pathology, pre-operative screening results, and pre-/post-operative cancer diagnoses were evaluated. One hundred and eighty-three high-risk women had risk reducing surgery at a mean age of 50. Read More

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http://dx.doi.org/10.1016/j.gore.2019.01.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365389PMC
May 2019
1 Read

Reversing platinum resistance in ovarian cancer multicellular spheroids by targeting Bcl-2.

Onco Targets Ther 2019 29;12:897-906. Epub 2019 Jan 29.

Department of Chemotherapy, Cancer Center, Qilu Hospital of Shandong University, Jinan, Shandong 250012, China,

Purpose: Peritoneal metastasis is the most common pathway for the spread of ovarian cancer. Ovarian cancer cells in ascites prefer to aggregate into the more chemoresistant multicellular spheroids (MCSs), leading to treatment failure and disease recurrence. We previously established a suspension MCS model of ovarian cancer cells in vitro and found that the MCS cells acquired drug resistance to cisplatin. Read More

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http://dx.doi.org/10.2147/OTT.S187015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357888PMC
January 2019

Macrophages infiltrating endometriosis-like lesions exhibit progressive phenotype changes in a heterologous mouse model.

J Reprod Immunol 2019 Jan 25;132:1-8. Epub 2019 Jan 25.

Robinson Research Institute and Adelaide Medical School, The University of Adelaide, Adelaide, SA 5000, Australia; The Women's and Children's Hospital, Department of Obstetrics and Gynaecology, North Adelaide, SA 5006, Australia. Electronic address:

Endometriotic lesion development involves complex interactions between endometrial tissue, the peritoneum and immune cells. Macrophages are essential in this process; however their precise roles are not defined. To investigate whether infiltrating macrophages acquire functionally different phenotypes during lesion development, human endometrial tissues were grafted into immunodeficient mice expressing macrophage-specific green fluorescent protein (GFP). Read More

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http://dx.doi.org/10.1016/j.jri.2019.01.002DOI Listing
January 2019

Postoperative hyperglycemia in patients undergoing cytoreductive surgery and HIPEC: a cohort study.

Int J Surg 2019 Feb 14. Epub 2019 Feb 14.

Department of Surgery, The Pennsylvania State University, College of Medicine, Hershey, PA, USA. Electronic address:

Background: Hyperglycemia following elective or emergency surgery is generally associated with an increased risk of complications. The impact of hyperglycemia following surgery for peritoneal surface malignancy remains unclear.

Materials And Methods: Records of patients undergoing cytoreduction and HIPEC for peritoneal surface malignancy were reviewed at two institutions. Read More

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http://dx.doi.org/10.1016/j.ijsu.2019.02.005DOI Listing
February 2019

Development and Validation of a Risk-Calculator for Adverse Perioperative Outcomes for Women with Ovarian Cancer.

Am J Obstet Gynecol 2019 Feb 13. Epub 2019 Feb 13.

Columbia University College of Physicians and Surgeons; Herbert Irving Comprehensive Cancer Center, Columbia University College of Physicians and Surgeons; New York Presbyterian Hospital. Electronic address:

Background: Primary cytoreduction followed by platinum based chemotherapy is the primary treatment for advanced ovarian cancer. However neoadjuvant chemotherapy followed by interval debulking is an alternative option, particularly in those who may be poor surgical candidates.

Objective: The objective of this study was to determine factors associated with short term, significant perioperative morbidity and mortality for women undergoing surgery for ovarian cancer and to create a nomogram to predict the risk of adverse perioperative outcomes. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00029378193036
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http://dx.doi.org/10.1016/j.ajog.2019.02.019DOI Listing
February 2019
4 Reads

Performance of the MasSpec Pen for Rapid Diagnosis of Ovarian Cancer.

Clin Chem 2019 Feb 15. Epub 2019 Feb 15.

Department of Chemistry, The University of Texas at Austin, Austin, TX

Background: Accurate tissue diagnosis during ovarian cancer surgery is critical to maximize cancer excision and define treatment options. Yet, current methods for intraoperative tissue evaluation can be time intensive and subjective. We have developed a handheld and biocompatible device coupled to a mass spectrometer, the MasSpec Pen, which uses a discrete water droplet for molecular extraction and rapid tissue diagnosis. Read More

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http://dx.doi.org/10.1373/clinchem.2018.299289DOI Listing
February 2019
1 Read

Trans-Fascial Placement of a High, Sub Muscular Reservoir in Patients Following Radical Cystectomy: Safety, Efficacy, and Predictability of Final Reservoir Location Verified With Abdominal Imaging.

J Sex Med 2019 Feb;16(2):338-345

Department of Urology, University of Miami Miller School of Medicine, Miami, FL, USA.

Introduction: With the increasing utilization of ectopic reservoir placement during multicomponent penile implant surgery, safety concerns have been raised about whether passing the reservoir through the floor of the inguinal canal consistently results in placement of the reservoir within the correct location.

Aim: To evaluate the safety, efficacy, and patient satisfaction associated with direct-vision, trans-fascial sub muscular reservoir placement in consecutive patients who had previously undergone radical cystectomy.

Methods: Perioperative data, complications, and follow up for the 12 cystectomy patients were evaluated using a comprehensive database of consecutive patients undergoing penile prosthesis placement at our center. Read More

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http://dx.doi.org/10.1016/j.jsxm.2018.12.015DOI Listing
February 2019
1 Read

Progressive Oncological Surgery Is Associated with Increased Curative Resection Rates and Improved Survival in Metastatic Colorectal Cancer.

Cancers (Basel) 2019 Feb 14;11(2). Epub 2019 Feb 14.

Department of Surgery, Paracelsus Medical University, 5020 Salzburg, Austria.

Background: Secondary resection rates in first-line chemotherapy trials for metastatic colorectal cancer (mCRC) remain below 15%, representing a clear contrast to reports by specialised surgical centres, where progressive liver, peritoneal-surface, and pulmonary surgery increased access to curative-intent treatment. We present a long-term evaluation of oncosurgical management in a single-centre, analysing the aggregate effect of gradual implementation of surgical subspecialties and systemic treatments on mCRC patients' resection rates and prognosis.

Methods: Patients with newly diagnosed mCRC from 2003 to 2014 were retrospectively categorised into palliative treatment (PAT) and curative intent surgery (CIS) and three time periods were analysed for treatment changes and factors associated with survival. Read More

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http://dx.doi.org/10.3390/cancers11020218DOI Listing
February 2019
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Tumoral NOX4 recruits M2 tumor-associated macrophages via ROS/PI3K signaling-dependent various cytokine production to promote NSCLC growth.

Redox Biol 2019 Feb 6;22:101116. Epub 2019 Feb 6.

Department of Pharmacology, School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China; Guangzhou Key Laboratory of Construction and Application of New Drug Screening Model Systems, Guangdong Pharmaceutical University, Guangzhou 510006, China; Key Laboratory of New Drug Discovery and Evaluation of Ordinary Universities of Guangdong Province, Guangdong Pharmaceutical University, Guangzhou 510006, China. Electronic address:

M2-type tumor-associated macrophages (TAMs) infiltration contributes to cancer malignant progression. However, the mechanisms for controlling recruitment and M2 polarization of macrophages by cancer cells are largely unclear. NADPH oxidase 4 (NOX4) is abundantly expressed in non-small cell lung cancer (NSCLC) and mediates cancer progression. Read More

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http://dx.doi.org/10.1016/j.redox.2019.101116DOI Listing
February 2019
1 Read

Novel Prevention Procedure for Inguinal Hernia after Robot-Assisted Radical Prostatectomy: Results from a Prospective Randomized Trial.

J Endourol 2019 Feb 15. Epub 2019 Feb 15.

Kanazawa, Japan ;

Objectives: To conduct a prospective randomized trial to evaluate the efficacy of a novel prophylactic procedure for inguinal hernia (IH) after transperitoneal robot-assisted radical prostatectomy (RARP).

Materials And Methods: The prophylactic procedure for IH after RARP involved the dissection of the peritoneum approximately 5 cm outward from internal inguinal ring, separating the spermatic cord and vessels from the peritoneum. This was randomly performed on one side (left or right). Read More

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http://dx.doi.org/10.1089/end.2018.0898DOI Listing
February 2019
1 Read

A Phase 2 Study of Induction Chemotherapy Using Docetaxel, Cisplatin, and S-1 for Gastric Cancer with Peritoneal Metastasis (KUGC06).

Ann Surg Oncol 2019 Feb 14. Epub 2019 Feb 14.

Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Background: The authors previously showed the significant efficacy of S-1 plus cisplatin for gastric cancer with limited peritoneal metastasis. They conducted a phase 2 study to evaluate the safety and efficacy of induction chemotherapy using a docetaxel, cisplatin, and S-1 (DCS) triplet regimen to treat gastric cancer with peritoneal metastasis.

Methods: The key eligibility criteria were gastric cancer with peritoneal metastasis or positive peritoneal cytology but no other distant metastases and capability of oral administration. Read More

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http://dx.doi.org/10.1245/s10434-019-07229-7DOI Listing
February 2019

The Relevance of Serosal Exposure Without Nodal Metastasis in Resectional Gastric Cancer.

Ann Surg Oncol 2019 Feb 14. Epub 2019 Feb 14.

Division of Gastrointestinal Surgery, Department of Surgery, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Background: According to 8th AJCC/UICC TNM criteria, stage IIB includes pT1N3M0, pT2N2M0, pT3N1M0, and pT4aN0M0, which includes not only early gastric cancer but also locally advanced cancer. There are currently no data about whether there is any additional impact of serosal exposed cancer without nodal metastasis (pT4aN0) on patients' survival outcomes compared with other subgroups in IIB.

Methods: Patients who underwent radical gastrectomy for gastric cancer patients were enrolled, including 427 patients in stage IIB; 20 (4. Read More

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http://link.springer.com/10.1245/s10434-019-07221-1
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http://dx.doi.org/10.1245/s10434-019-07221-1DOI Listing
February 2019
5 Reads

Pressurized intraperitoneal aerosol chemotherapy procedure for nonresectable peritoneal carcinomatosis: First Indian study.

South Asian J Cancer 2019 Jan-Mar;8(1):27-30

Department of Surgical Oncology, Manipal Hospital, Bengaluru, Karnataka, India.

Background: Peritoneal carcinomatosis (PC) is a common evolution of abdominal cancers and is associated with poor prognosis. A few selected patients have option of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy, but majority who are not eligible for curative approach can undergo pressurized intraperitoneal aerosol chemotherapy (PIPAC). It is an emerging field of research with major therapeutic potential. Read More

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http://journal.sajc.org/text.asp?2019/8/1/27/250100
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http://dx.doi.org/10.4103/sajc.sajc_92_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348786PMC
February 2019
2 Reads

Regulation of the bi-directional cross-talk between ovarian cancer cells and adipocytes by SPARC.

Oncogene 2019 Feb 14. Epub 2019 Feb 14.

Department of Cancer Biology, Wake Forest University School of Medicine, Winston-Salem, NC, USA.

Ovarian cancer (OvCa) exhibits a specific predilection for metastasis to the omentum. Our earlier studies highlighted the tumour-suppressor effect of secreted protein acidic and rich in cysteine (SPARC) in OvCa through multi-faceted roles inhibiting cancer cell interactions within the peritoneal milieu. The goal of this study is to investigate the role of SPARC in OvCa interactions with omental adipocytes and its role in OvCa colonization in the omentum. Read More

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http://dx.doi.org/10.1038/s41388-019-0728-3DOI Listing
February 2019
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[Multi-Look Staging Laparoscopy and Conversion Surgery for Gastric Cancer with Peritoneal Metastases].

Gan To Kagaku Ryoho 2019 Jan;46(1):184-186

Dept. of Gastroenterological Surgery, Osaka University Graduate School of Medicine.

A 46-year-old male patient with anorexia consulted our hospital. A scirrhous gastric cancer was found, and he was introduced to us. Laparoscopic examination was performed, and advanced peritoneal disseminated nodules were confirmed(CY1, P1). Read More

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January 2019
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[A Case of Gastric Small Cell Carcinoma with Rapid Regrowth after Surgery].

Gan To Kagaku Ryoho 2019 Jan;46(1):145-147

Dept. of Surgery, Tsuyama Chuo Hospital.

The patient was a 59-year-old man with type 2 advanced gastric cancer in the antrum. Abdominal computed tomography revealed the primary tumor with regional lymph node metastasis. Distal gastrectomy and D2 lymph node dissection were performed. Read More

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January 2019
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[Postoperative Recurrence of Pancreatic Cancer Successfully Treated with the Gemcitabine plus Oxaliplatin Regimen Resulting in Long-Term Survival-ACase Report].

Gan To Kagaku Ryoho 2019 Jan;46(1):142-144

Dept. of Surgery, Odawara Municipal Hospital.

A 38-year-old woman who presented with complaints of back pain was diagnosed with cancer of the pancreatic body. Since invasion of the celiac artery/superior mesenteric artery was suspected, she was referred to our department for chemotherapy. She received 4 courses of gemcitabine plus S-1(GS), and she underwent distal pancreatectomy with en bloc celiac axis resection/portal vein resection/reconstruction using a left renal vein graft(OP-CAR). Read More

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January 2019
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[A Case of Robot-Assisted Conversion Surgery for Gastric Cancer with Peritoneal Dissemination That Responded to Intravenous and Intraperitoneal Paclitaxel Combined with S-1 Chemotherapy].

Gan To Kagaku Ryoho 2019 Jan;46(1):112-114

Dept. of Surgery, Fujita Health University.

This case involved a 69-year-old female patient with peritoneal dissemination of an advanced gastric cancer. She underwent chemotherapy comprisingintravenous and intraperitoneal paclitaxel combined with S-1. After 20 courses, a staging laparoscopy was performed, and pathological analysis of the peritoneal dissemination and cytologic analysis of ascites fluid yielded negative results. Read More

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January 2019
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[Curatively Resected Stage ⅣGastric Cancer with Positive Peritoneal Cytology Due to SOX Therapy-A Case Report].

Gan To Kagaku Ryoho 2019 Jan;46(1):71-74

Dept. of Digestive Surgery, Kawaguchi Municipal Medical Center.

A 70-year-old man with epigastralgia who initially visited a local hospital was referred to us for further examination. Gastrointestinal endoscopy exhibited a type 3 tumor of the stomach from the body to the antrum(adenocarcinoma, por1). Contrast-enhanced CT revealed thickness in the wall of the gastric body with bulky lymph nodes and ascites. Read More

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January 2019
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Right versus left sided metastatic colorectal cancer: Teasing out clinicopathologic drivers of disparity in survival.

Asia Pac J Clin Oncol 2019 Feb 13. Epub 2019 Feb 13.

Footscray Hospital, Western Health, Footscray, Victoria, Australia.

Background: Metastatic colorectal cancer (mCRC) patients with a right-sided primary (RC) have an inferior survival to mCRC arising from a left-sided primary (LC). Previous analyses have suggested multiple factors contribute.

Methods: The Treatment of Recurrent and Advanced Colorectal Cancer (TRACC) Registry prospectively captured data on consecutive mCRC patients. Read More

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http://dx.doi.org/10.1111/ajco.13135DOI Listing
February 2019
1 Read
1.058 Impact Factor

Ouabain promotes immune responses in WEHI-3 cells to generate leukemia mice through enhancing phagocytosis and natural killer cell activities in vivo.

Environ Toxicol 2019 Feb 13. Epub 2019 Feb 13.

Department of Biological Science and Technology, China Medical University, Taichung, Taiwan.

Ouabain, a cardiotonic steroid, was used for the treatment of heart failure and atrial fibrillation and induces cancer cell apoptosis in many human cancer cells including human leukemia cells. However, there are no reports to show the effects on immune responses in a leukemia mouse model. In this study, WEHI-3 cell generated leukemia mice were developed and treated by oral ouabain at 0, 0. Read More

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http://dx.doi.org/10.1002/tox.22732DOI Listing
February 2019
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Cytoreductive surgery and heated intraperitoneal chemotherapy for peritoneal carcinomatosis from rare etiologies.

Am J Surg 2019 Jan 25. Epub 2019 Jan 25.

Department of Surgery and Oncology, Foothills Medical Centre, University of Calgary, Calgary, Alberta, Canada. Electronic address:

Background: Cytoreductive surgery and heated intraperitoneal chemotherapy (CRS/HIPEC) are commonly used in the treatment of peritoneal carcinomatosis (PC) originating from colorectal, appendiceal and ovarian cancers. It is unclear what benefit CRS/HIPEC might have for PC from uncommon etiologies, therefore we sought to describe local practice patterns and evaluate overall survival (OS).

Methods: All patients who had CRS/HIPEC between 2000 and 2016 were identified using our institutional cancer database. Read More

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http://dx.doi.org/10.1016/j.amjsurg.2019.01.011DOI Listing
January 2019
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Operative Management of Recurrent and Metastatic Adrenocortical Carcinoma: A Systematic Review.

Am Surg 2019 Jan;85(1):23-28

Metastatic adrenocortical carcinoma (ACC) is associated with a poor 5-year survival rate and high rate of recurrence. Outcomes after resection for patients with limited disease remain poorly described. We conducted a PubMed search for articles published between 1950 and 2017 using the terms "ACC," "recurrence," and "surgery. Read More

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January 2019
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A case of successfully resected metachronous gastric and gallbladder metastases from pancreatic body cancer.

Surg Case Rep 2019 Feb 13;5(1):21. Epub 2019 Feb 13.

Department of General Surgery, Chiba University, Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba-shi, Chiba, 260-8670, Japan.

Background: Pancreatic ductal adenocarcinoma (PDAC) readily metastasizes to the lymph nodes, liver, lung, and peritoneum; however, gastric and gallbladder metastases are rare. We report a case of metachronous gastric and gallbladder metastases from PDAC.

Case Presentation: The patient is a 71-year-old man who underwent distal pancreatectomy for PDAC. Read More

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http://dx.doi.org/10.1186/s40792-019-0581-1DOI Listing
February 2019
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TOTAL OMENTECTOMY IN GASTRIC CANCER SURGERY: IS IT ALWAYS NECESSARY?

Arq Bras Cir Dig 2019 Feb 7;32(1):e1425. Epub 2019 Feb 7.

Discipline of Digestive Surgery, Department of Gastroenterology, Faculty of Medicine, University of São Paulo, São Paulo, SP, Brazil.

Background: Traditionally, total omentectomy is performed along with gastric resection and extended lymphadenectomy in gastric cancer (GC) surgery. However, solid evidences regarding its oncologic benefit is still scarce.

Aim: To evaluate the incidence of metastatic omental lymph nodes (LN) in patients undergoing curative gastrectomy for GC, as well as its risk factors and patients' outcomes. Read More

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http://dx.doi.org/10.1590/0102-672020180001e1425DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368152PMC
February 2019
1 Read