42,537 results match your criteria Peritoneal Cancer


COVID-19 and Renal Failure: Challenges in the Delivery of Renal Replacement Therapy.

J Clin Med Res 2020 May 8;12(5):276-285. Epub 2020 May 8.

Division of Nephrology, Lynchburg Nephrology Physicians, Lynchburg, VA, USA.

Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), first officially reported in December 2019 in Wuhan City, Hubei province, China, and has since lead to a pandemic. Most cases result in minor symptoms such as cough, fever, sore throat, myalgia, fatigue, nausea, diarrhea, loss of smell, and abdominal pain. As of April 8, 2020, more than 1,485,000 cases of COVID-19 have been reported in more than 200 countries and territories, resulting in over 90,000 deaths. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.14740/jocmr4160DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7239583PMC

SALL4 promotes gastric cancer progression via hexokinase II mediated glycolysis.

Cancer Cell Int 2020 24;20:188. Epub 2020 May 24.

Jiangsu Key Laboratory of Medical Science and Laboratory Medicine, School of Medicine, Jiangsu University, 301 Xuefu Road, Zhenjiang, Jiangsu 212013 China.

Background: The stem cell factor SALL4 is reactivated in human cancers. SALL4 plays diverse roles in tumor growth, metastasis, and drug resistance, but its role in tumor metabolism has not been well characterized.

Methods: The glycolytic levels of gastric cancer cells were detected by glucose uptake, lactate production, lactate dehydrogenase activity, ATP level, and hexokinase activity. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12935-020-01275-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247129PMC

Knockdown of NCOA2 Inhibits the Growth and Progression of Gastric Cancer by Affecting the Wnt Signaling Pathway-Related Protein Expression.

Technol Cancer Res Treat 2020 Jan-Dec;19:1533033820928072

Department of Gastroenterological Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China.

Objective: The aim of the study is to determine the role of nuclear receptor coactivator 2 in cell proliferation and invasion ability of gastric cancer cells and to explore its possible mechanisms.

Methods: Immunohistochemical staining was used to determine gene expression in gastric cancer. Western blotting was used to detect Wnt signal pathways-related protein expression. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1533033820928072DOI Listing

Influence of previous laparo-endoscopic inguinal hernia repair on performing radical prostatectomy: a nationwide survey among urological surgeons.

Surg Endosc 2020 Jun 2. Epub 2020 Jun 2.

Department of Surgery/Hernia Clinic, Diakonessenhuis Utrecht/Zeist, Secretariaat Heelkunde, Professor Lorentzlaan 76, 3707 HL, Zeist, The Netherlands.

Background: There is considerable demographic overlap of inguinal hernia patients and prostate cancer patients. Previous laparo-endoscopic inguinal hernia mesh repairs can complicate subsequent radical prostatectomies due to adhesions and distortion of anatomic planes. This study aims to assess the experience of urological surgeons on the safety and feasibility of performing radical prostatectomies after laparo-endoscopic inguinal hernia mesh repair. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00464-020-07676-4DOI Listing

Interleukin-17A derived from mast cells contributes to fibrosis in gastric cancer with peritoneal dissemination.

Gastric Cancer 2020 Jun 2. Epub 2020 Jun 2.

Division of Cancer Medicine, Department of Gastroenterological Surgery, Graduate School of Medical Science, Kanazawa University, 13-1 Takara-machi, Kanazawa, Ishikawa, 920-8641, Japan.

Objectives: Interleukin-17A (IL-17A) is pro-inflammatory cytokine and acts as profibrotic factor in the fibrosis of various organs. Fibrosis tumor-like peritoneal dissemination of gastric cancer interferes with drug delivery and immune cell infiltration because of its high internal pressure. In this study, we examined the relationship between IL-17A and tissue fibrosis in peritoneal dissemination and elucidated the mechanism of fibrosis induced by IL-17A using human peritoneal mesothelial cells (HPMCs) and a mouse xenograft model. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10120-020-01092-2DOI Listing

Estimating the Prevalence of Pseudomyxoma Peritonei in Europe Using a Novel Statistical Method.

Ann Surg Oncol 2020 Jun 2. Epub 2020 Jun 2.

Department of Tumor Biology, The Norwegian Radium Hospital, Oslo University Hospital Oslo, Oslo, Norway.

Background: The determination of the incidence and prevalence of rare diseases is important for economists and health-care providers. Pseudomyxoma peritonei (PMP) is a rare, slow-growing abdominal cancer that represents a substantial burden on both patients and health-care systems. The incidence rate was previously approximated at 1-2 people per million per year; this incidence has never been challenged, and the prevalence has not been estimated. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1245/s10434-020-08655-8DOI Listing

Use of ablation and ultrasonic aspiration at primary debulking surgery in advanced stage ovarian, fallopian tube, and primary peritoneal cancer.

Int J Gynecol Cancer 2020 Jun 2. Epub 2020 Jun 2.

Division of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Objectives: Ovarian cancer patients with miliary disease have the lowest rates of complete surgical resection and poorest survival. Adjunct surgical techniques may potentially increase rates of complete surgical resection. No studies have evaluated the use of these techniques in primary debulking surgery for ovarian cancer patients with miliary disease. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/ijgc-2020-001466DOI Listing

Differential blood count as triage tool in evaluation of pelvic masses.

Int J Gynecol Cancer 2020 Jun 2. Epub 2020 Jun 2.

Dana Farber Cancer Institute, Boston, Massachusetts, USA.

Objective: Triaging patients with presumptive ovarian cancer to the appropriate specialist may improve survival. Therefore, there is increasing interest in complementary diagnostic markers to the standard serum CA125. In patients with pelvic masses, we examined the ability of epidemiologic variables and preoperative differential blood counts to improve detection of ovarian cancer over CA125 alone. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/ijgc-2019-001103DOI Listing

Gastric Cancer Staging: Is It Time for Magnetic Resonance Imaging?

Cancers (Basel) 2020 May 29;12(6). Epub 2020 May 29.

Radiology Unit, Department of Experimental, Diagnostic and Speciality Medicine, Sant'Orsola Hospital, University of Bologna, 40138 Bologna, Italy.

Gastric cancer (GC) is a common cancer worldwide. Its incidence and mortality vary depending on geographic area, with the highest rates in Asian countries, particularly in China, Japan, and South Korea. Accurate imaging staging has become crucial for the application of various treatment strategies, especially for curative treatments in early stages. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/cancers12061402DOI Listing

Elimination of dormant, autophagic ovarian cancer cells and xenografts through enhanced sensitivity to anaplastic lymphoma kinase inhibition.

Cancer 2020 Jun 2. Epub 2020 Jun 2.

Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Background: Poor outcomes for patients with ovarian cancer relate to dormant, drug-resistant cancer cells that survive after primary surgery and chemotherapy. Ovarian cancer (OvCa) cells persist in poorly vascularized scars on the peritoneal surface and depend on autophagy to survive nutrient deprivation. The authors have sought drugs that target autophagic cancer cells selectively to eliminate residual disease. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cncr.32985DOI Listing

Complete pathologic response after two-stage cytoreductive surgery with HIPEC for bulky pseudomyxoma peritonei: proof of concept.

Int J Hyperthermia 2020 ;37(1):585-591

Surgical Oncology Department, Montpellier Cancer Institute, University of Montpellier, Montpellier, France.

Pseudomyxoma peritonei (PMP) is a rare disease characterized by the progressive accumulation of mucinous ascites and peritoneal implants. The optimal treatment for PMP includes the association of complete cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC). For patients with a large burdensome disease, the completeness of cytoreduction sometimes requires maximal effort surgery. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/02656736.2020.1772511DOI Listing
January 2020

[The perioperative safety of cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy for pseudomyxoma peritonei].

Zhonghua Zhong Liu Za Zhi 2020 May;42(5):419-424

Department of Peritoneal Cancer Surgery, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China.

This study was to investigate the perioperative safety of cytoreductive surgery (CRS) plus hyperthermic intraperitoneal chemotherapy (HIPEC) for pseudomyxoma peritonei (PMP), and analyze the risk factors of serious adverse events (SAEs). The occurrences of perioperative SAEs were retrospectively analyzed in 254 PMP patients treated with CRS plus HIPEC. Univariate and multivariate analysis were performed to identify independent risk factors. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3760/cma.j.cn112152-112152-20190430-00278DOI Listing

-Acetyl-l-cysteine Enhances the Effect of Selenium Nanoparticles on Cancer Cytotoxicity by Increasing the Production of Selenium-Induced Reactive Oxygen Species.

ACS Omega 2020 May 12;5(20):11710-11720. Epub 2020 May 12.

Biology Postdoctoral Research Station, Guangzhou Jinan Biomedicine Research and Development Center, Institute of Biomedicine, College of Life Science and Technology, Jinan University, Guangzhou, Guangdong 510632, P. R. China.

Peritoneal carcinomatosis (PC) has an extremely poor prognosis, which leads to a significantly decreased overall survival in patients with peritoneal implantation of cancer cells. Administration of sodium selenite by intraperitoneal injection is highly effective in inhibiting PC. Our previous study found that selenium nanoparticles (SeNPs) have higher redox activity and safety than sodium selenite. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acsomega.0c01034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7254790PMC

Vitamin C Inhibits Metastasis of Peritoneal Tumors By Preventing Spheroid Formation in ID8 Murine Epithelial Peritoneal Cancer Model.

Front Pharmacol 2020 12;11:645. Epub 2020 May 12.

Department of Urology, Qilu Hospital, Shandong University, Jinan, China.

High mortality is associated with exclusively metastasis within the peritoneal cavity among patients with epithelial ovarian cancer that is the most lethal gynecologic cancer. There is an unmet need to develop more effective therapies to prevent metastasis of peritoneal cancer. Multicellular spheroid formation, during which cancer cells migrate and adhere to tumor-associated macrophages, is a critical step of ovarian cancer metastasis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fphar.2020.00645DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7236773PMC

Impact of a standardized reporting format on the quality of MRI reports for rectal cancer staging.

Indian J Radiol Imaging 2020 Jan-Mar;30(1):7-12. Epub 2020 Mar 30.

Department of Radio Diagnosis, Tata Memorial Hospital, Mumbai, Maharashtra, India.

Background And Aims: Besides providing a surgical roadmap, rectal MRI plays a major role in treatment planning. We recently started using a structured template for reporting rectal cancer via MRI. We study the impact of using this template at our hospital in terms of number of essential imaging parameters described in the reports as compared to the pre-template free-text reports. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/ijri.IJRI_308_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240900PMC

Peritoneal Carcinomatosis of Colorectal Origin in Cyclosporine Immunosuppressed Rats.

Gulf J Oncolog 2020 May;1(33):27-30

Surgical Research Laboratory, Saint Joseph University, Beirut, Lebanon.

Objective: We evaluate the seeding step of peritoneal carcinomatosis cancer as a surrogate for the role of the omentum in colorectal tumors.

Methods: The study included 5 groups of adult male Sprague Dawley rats: immunocompetent rats (group 1), immunosuppressed rats without omentectomy (group 2), immunosuppressed rats with omentectomy (group 3), immunosuppressed rats with omentectomy receiving NSAID (group 4), and immunosuppressed rats without omentectomy receiving NSAID (group 5). Except for group 1, the rats were immunosuppressed using cyclosporine orally at a dose of 25 mg/kg/day that was started 48 hours before tumor cell infiltration in the peritoneum. Read More

View Article

Download full-text PDF

Source

Combined Intraoperative Radiotherapy (IORT) and Hyperthermic Intraperitoneal Chemotherapy (HIPEC) with Cytoreduction Surgery (CRS) as a Novel Approach in the Management of Resectable Pancreatic Cancer.

Gulf J Oncolog 2020 May;1(33):19-26

Surgical Oncology Department, Oncology Center, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.

Background: Pancreatic cancer is leading cause of cancer related deaths. The prognosis is usually very poor. In spite of the advances in modern surgery, the outcome is still poor. Read More

View Article

Download full-text PDF

Source

Feasibility and Safety of Laparoscopic Radical Distal Pancreatosplenectomy with Adrenalectomy in Advanced Pancreatic Cancer.

Ann Surg Oncol 2020 May 31. Epub 2020 May 31.

Department of Hepatobiliary and Pancreatic Surgery, Yonsei University College of Medicine, Seoul, Korea.

Introduction: Pancreatic adenocarcinoma is a lethal condition with poor outcomes and an increasing incidence.1 However, recent meta-analysis reported improved survival and R0 resection rate following neoadjuvant chemotherapy with subsequent surgery in initially unresectable pancreatic cancer.2 In addition, as a result of technological advances during the past 2 decades, even in pancreatic cancers, minimally invasive surgery (MIS) approaches are being used more frequently and safely. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1245/s10434-020-08670-9DOI Listing

Role of pleural and peritoneal metastasis in immune checkpoint inhibitors efficacy patients with non-small cell lung cancer: real-world data from a large cohort in France.

J Cancer Res Clin Oncol 2020 May 30. Epub 2020 May 30.

Department of Medical Oncology, Center Georges François Leclerc, 1 rue du Professeur Marion, 21000, Dijon, France.

Background: Checkpoint inhibitors (CKI) targeting PD-1 or PD-L1 are major therapies for the treatment of non-small cell lung cancer (NSCLC). Despite numerous studies of biological biomarkers, we currently lack a marker to predict CKI primary resistance. The aim of this study was to isolate clinical markers associated with the absence of efficacy of CKI used as monotherapy in NSCLC. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00432-020-03262-2DOI Listing

The Peritoneal Cancer Index is a Strong Predictor of Incomplete Cytoreductive Surgery in Ovarian Cancer.

Ann Surg Oncol 2020 May 29. Epub 2020 May 29.

Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden.

Background: Extent of tumor load is an important factor in the selection of ovarian cancer patients for cytoreductive surgery (CRS). The Peritoneal Cancer Index (PCI) gives exact information on tumor load but still is not standard in ovarian cancer surgery. The aim of this study was to find a PCI cutoff for incomplete CRS. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1245/s10434-020-08649-6DOI Listing

Effects of educational practices on the peritonitis risk in peritoneal dialysis: a retrospective cohort study with data from the French peritoneal Dialysis registry (RDPLF).

BMC Nephrol 2020 May 29;21(1):205. Epub 2020 May 29.

Normandie Univ, UNICAEN, CUMR, CHU de Caen Normandie, Néphrologie, Avenue de la cote de nacre, 14033, Caen-Cedex, France.

Background: Peritoneal dialysis (PD) is a home-based therapy performed by patients or their relatives in numerous cases, and the role of patients' educational practices in the risk of peritonitis is not well assessed. Our aim was to evaluate the effect of PD learning methods on the risk of peritonitis.

Methods: This was a retrospective multicentric study based on data from a French registry. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12882-020-01867-wDOI Listing

Encorafenib, Binimetinib, and Cetuximab in BRAF V600E-Mutated Colorectal Cancer.

Transl Oncol 2020 May 26;13(9):100795. Epub 2020 May 26.

Azienda Ospedaliera Careggi University Hospital of Florence and University of Florence, 50134 Florence, Italy.

BRAFV600-mutated colorectal cancer (CRC) accounts for 8% to 12% of all CRC diagnoses. These tumors are often associated with specific patient features, including right-sided primary tumor location, peritoneal and non-regional lymph node involvement, and poor prognosis. In approximately 30% of cases, a simultaneous mismatch repair deficient (dMMR)/microsatellite instability-high (MSI-H) phenotype is identified. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.tranon.2020.100795DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260582PMC

Splenic artery pseudoaneurysm following chemotherapy in a patient with pancreatic cancer: a case report.

Clin J Gastroenterol 2020 May 28. Epub 2020 May 28.

Department of Surgery, The Jikei University School of Medicine, 3-25-8, Nishi-Shinbashi, Minato-ku, Tokyo, 105-8461, Japan.

A 48-year-old man presented with epigastralgia and back pain. Radiological evaluation revealed a pancreatic tail tumor with contrast enhancement and an intratumoral fluid component involving the splenic artery and invading the left kidney. Endoscopic ultrasound-guided fine-needle aspiration biopsy revealed an adenocarcinoma, and based on invasion of the left kidney, the patient was diagnosed with unresectable pancreatic cancer with suspected peritoneal dissemination. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12328-020-01137-0DOI Listing

ASO Author Reflections: Use of Peritoneal Cancer Index (PCI) to Evaluate Carcinomatosis in Ovarian Cancer.

Ann Surg Oncol 2020 May 28. Epub 2020 May 28.

Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1245/s10434-020-08664-7DOI Listing

WJOG10517G: a multicenter Phase II study of mFOLFOX6 in gastric cancer patients with severe peritoneal metastases.

Future Oncol 2020 May 29. Epub 2020 May 29.

Department of Clinical Oncology, Aichi Cancer Center Hospital, Nagoya, Japan.

Gastric cancer patients with severe peritoneal metastases, defined as massive ascites and/or inadequate oral intake, have been excluded from clinical trials of new treatments due to poor prognosis and tumor-related complications, such as ileus. Based on the results of the JCOG1108/WJOG7312G study, their prognosis when treated with 5-fluorouracil/-leucovorin or 5-fluorouracil/-leucovorin plus paclitaxel remained extremely poor in this setting. Retrospective studies have shown the promising efficacy of the modified FOLFOX6 (mFOLFOX6) regimen, with improved ascites and oral intake. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2217/fon-2020-0298DOI Listing

The impact of novel coronavirus SARS-CoV-2 among healthcare workers in hospitals: An aerial overview.

Am J Infect Control 2020 May 25. Epub 2020 May 25.

Department of Gastrointestinal Surgery, Wuhan Peritoneal Cancer Clinical Medical Research Center, Zhongnan Hospital of Wuhan University, Hubei Key Laboratory of Tumor Biological Behaviors and Hubei Cancer Clinical Study Center, Wuhan 430071, Hubei, China. Electronic address:

The ongoing outbreak of COVID-19, caused by the novel coronavirus SARS-CoV-2, places healthcare workers at an increased risk of infection as they are in close contact with patients. In this article, we report an overview of cases of infected healthcare workers in China and Italy during the early periods of the COVID-19 epidemic. China's coronavirus response highlights the importance of implementing effective public health strategies. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ajic.2020.05.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247977PMC

The prevalence of occult ovarian cancer in the series of 155 consequently operated high risk asymptomatic patients - Slovenian population based study.

Radiol Oncol 2020 May 28;54(2):180-186. Epub 2020 May 28.

Cancer Genetics Clinic, Institute of Oncology Ljubljana, Ljubljana, Slovenia.

Background We assessed the prevalence, localization, type and outcome of occult cancer at risk-reducing salpingo-oophorectomy or salpingectomy (RRSO) in asymptomatic carriers of pathogenic or likely pathogenic BRCA1/2 variants and high-risk BRCA1/2 negative women. Patients and methods A retrospective analysis of all consecutive gynaecologic preventive surgeries from January 2009 to December 2015 was performed. Participants underwent genetic counselling and BRCA1/2 testing before the procedure. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2478/raon-2020-0020DOI Listing

Standard and multivisceral colectomy in locally advanced colon cancer.

Radiol Oncol 2020 May 28. Epub 2020 May 28.

Department of Surgery ,N1, Yerevan State Medical University after M.Heratsi, Yerevan, Armenia.

Background Management of locally advanced colon cancer (LACC) is challenging. Surgery is the mainstay of the treatment, yet its outcomes remain unclear, especially in the setting of multivisceral resections. The aim of the study was to examine the outcomes of standard and multivisceral colectomy in patients with LACC. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2478/raon-2020-0032DOI Listing

A case of a unique presentation of a primary vaginal endometrioid adenocarcinoma arising in the setting of a recurrent peritoneal inclusion cyst fistulized to the vagina.

Gynecol Oncol Rep 2020 Aug 16;33:100585. Epub 2020 May 16.

University of Cincinnati Department of Obstetrics & Gynecology: Division of Gynecologic Oncology, 234 Goodman Street, Cincinnati, OH 45219, USA.

Primary vaginal endometrioid adenocarcinoma is a rare cancer that is often associated with chronic endometriosis. We present the case of a 72-year-old female who underwent right salpingo-oophorectomy followed by hysterectomy with benign pathology 25 years prior to her cancer diagnosis. She had an extensive surgical history in the intervening years and several complicating factors including a history of endometriosis as well as a recurrent peritoneal inclusion cyst treated with ethanol sclerotherapy, followed by formation of a peritoneal-vaginal fistula. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.gore.2020.100585DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243260PMC

Gastric cancer with peritoneal metastases: Efficiency of standard treatment methods.

World J Gastrointest Oncol 2020 May;12(5):569-581

Department of oncology and Radiology, Danylo Halytsky Lviv National Medical University, Lviv 79010, Ukraine.

Background: Peritoneal metastasis (PM), arising from gastric cancer (GC), is the most common pattern of synchronous and metachronous dissemination and is generally associated with poor prognosis. New therapeutic modalities are being increasingly employed for such patients.

Aim: To develop more advanced methods, it becomes necessary to study the results of existing standard treatment methods in patients with PM in order to perform a comparative analysis of the strategies. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4251/wjgo.v12.i5.569DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235180PMC

Neutropenia in colorectal cancer treated with oxaliplatin-based hyperthermic intraperitoneal chemotherapy: An observational cohort study.

World J Gastrointest Oncol 2020 May;12(5):549-558

Department of Surgery, University of New South Wales, Sydney 2217, New South Wales, Australia.

Background: The implications of neutropenia after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC) treatment have never been investigated.

Aim: To evaluate the occurrence of neutropenia and its effect on the risk of increased Clavien-Dindo morbidity as well as its effect on overall or disease-free survival.

Methods: All patients with colorectal peritoneal metastases (1996-2015) completing cytoreductive surgery and oxaliplatin-based HIPEC treatment from a bi-institutional database (Uppsala and Sydney) were included in the study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4251/wjgo.v12.i5.549DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235182PMC

3,3',5,5'-tetramethoxybiphenyl-4,4'diol induces cell cycle arrest in G2/M phase and apoptosis in human non-small cell lung cancer A549 cells.

Chem Biol Interact 2020 May 24:109133. Epub 2020 May 24.

Laboratory of Immunoparasitology of Neglected Diseases and Cancer, State University of Londrina, PR, Brazil.

Lung cancer is one of the leading causes of cancer-related death worldwide. It has aggressive manifestation, high ability to promote metastasis and late diagnosis. In the present study, we investigated the cytotoxic effect of 3,3',5,5'-tetramethoxybiphenyl-4,4'diol (TMBP), against the A549 human non-small cell lung carcinoma lineage. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cbi.2020.109133DOI Listing

Peritoneal spillage is not an issue in patients undergoing minimally invasive surgery for colorectal cancer.

World J Surg Oncol 2020 May 27;18(1):107. Epub 2020 May 27.

Department of Visceral, Minimally Invasive and Oncologic Surgery, Marien Hospital Düsseldorf, Düsseldorf, Germany.

Background: Surgery for colorectal cancer (CRC) is increasingly being performed via the minimally invasive route. However, reports of postoperative wound and port site seeding as well as peritoneal spillage have been worrisome. We investigated the risk of peritoneal spillage in patients undergoing laparoscopic surgery for CRC. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12957-020-01882-zDOI Listing

The structural effect of high intensity ultrasound on peritoneal tissue: a potential vehicle for targeting peritoneal metastases.

BMC Cancer 2020 May 27;20(1):481. Epub 2020 May 27.

Division of Colorectal Surgery, Department of Surgery, University of California Irvine, California, 92868, USA.

Background: High-intensity ultrasound (HIUS) has been increasingly investigated as a possible tool in the treatment of multiple tumor entities. However, there is only little knowledge on the effect of HIUS on the peritoneum. This preliminary study aims to investigate HIUS' potential for altering the peritoneal surface and potentially improving current treatments for peritoneal metastases. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12885-020-06981-4DOI Listing

Patterns of surgical care for women with ovarian cancer in New South Wales.

Aust N Z J Obstet Gynaecol 2020 May 26. Epub 2020 May 26.

The Cancer Institute NSW, Sydney, New South Wales, Australia.

Background: Little is known about the delivery of surgical services and outcomes for women with ovarian cancer across New South Wales (NSW).

Aim: The study objective was to provide a descriptive analysis of the proportion of women who had surgery for ovarian cancer in NSW in specialist gynaecological oncology hospitals and compare outcomes for women attending specialist and non-specialist services in NSW.

Materials And Methods: This study is a retrospective analysis of women with primary ovarian, fallopian tube or peritoneal cancer from 2009 to 2012. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ajo.13180DOI Listing

Rightward shift in colorectal cancer: experience in 1101 patients.

Minerva Chir 2020 May 26. Epub 2020 May 26.

General Surgery Unit, Parma University Hospital, Parma, Italy.

Background: In the past decades the right colon cancer showed a higher incidence rate than left colon cancer. This trend is known as "proximal shift" or "rightwards shift". We evaluated rightward shift phenomenon in our region. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.23736/S0026-4733.20.08263-2DOI Listing

The Role of Tumor-Associated Macrophages in the Progression and Chemoresistance of Ovarian Cancer.

Cells 2020 May 22;9(5). Epub 2020 May 22.

Institute of Medical Biology, Polish Academy of Sciences, 93-232 Lodz, Poland.

Tumor-associated macrophages (TAMs) constitute the main population of immune cells present in the ovarian tumor microenvironment. These cells are characterized by high plasticity and can be easily polarized by colony-stimulating factor-1, which is released by tumor cells, into an immunosuppressive M2-like phenotype. These cells are strongly implicated in both the progression and chemoresistance of ovarian cancer. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/cells9051299DOI Listing

Long-term response to Olaparib in carcinomatous meningitis of a mutated ovarian cancer: A case report.

Mol Clin Oncol 2020 Jul 27;13(1):73-75. Epub 2020 Apr 27.

Department of Medical Oncology, Georges-François Leclerc Anticancer Center, UNICANCER, F-21079 Dijon, France.

PARP inhibitors are considered as a treatment revolution in ovarian cancer management. Leptomeningeal metastasis is a rare event with poor prognosis. The present report presents an exceptional history of long term survival for a young patient treated with olaparib for carcinomatous meningitis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3892/mco.2020.2035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7241237PMC

CD24-targeted intraoperative fluorescence image-guided surgery leads to improved cytoreduction of ovarian cancer in a preclinical orthotopic surgical model.

EBioMedicine 2020 May 23;56:102783. Epub 2020 May 23.

Center for Cancer Biomarkers, CCBIO, Department of Clinical Science, University of Bergen, Jonas Lies vei 91B, 5021 Bergen, Norway. Electronic address:

Background: The completeness of resection is a key prognostic indicator in patients with ovarian cancer, and the application of tumour-targeted fluorescence image-guided surgery (FIGS) has led to improved detection of peritoneal metastases during cytoreductive surgery. CD24 is highly expressed in ovarian cancer and has been shown to be a suitable biomarker for tumour-targeted imaging.

Methods: CD24 expression was investigated in cell lines and heterogenous patient-derived xenograft (PDX) tumour samples of high-grade serous ovarian carcinoma (HGSOC). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ebiom.2020.102783DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7248677PMC

Laparoscopic Assisted DIEP Flap Harvest Minimizes Fascial Incision in Autologous Breast Reconstruction.

Plast Reconstr Surg 2020 May 21. Epub 2020 May 21.

Division of Plastic Surgery, Department of Surgery, University of Pennsylvania, Philadelphia, PA 19104.

Introduction: Total extra-peritoneal laparoscopic-assisted (TEP-lap-assisted) harvest of the deep inferior epigastric (DIE) vessels permits a decrease in myofascial dissection in DIEP flap breast reconstruction. We present a reliable technique that further decreases donor site morbidity in autologous breast reconstruction.

Methods: The authors conducted a retrospective cohort study of female subjects presenting to the senior surgeon from March 2018 to March 2019 for autologous breast reconstruction after a newly diagnosed breast cancer. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/PRS.0000000000007048DOI Listing

Role of tumour location and surgical extent on prognosis in T2 gallbladder cancer: an international multicentre study.

Br J Surg 2020 May 26. Epub 2020 May 26.

Department of Surgery and Cancer Research Institute, Seoul National University College of Medicine, Seoul, South Korea.

Background: In gallbladder cancer, stage T2 is subdivided by tumour location into lesions on the peritoneal side (T2a) or hepatic side (T2b). For tumours on the peritoneal side (T2a), it has been suggested that liver resection may be omitted without compromising the prognosis. However, data to validate this argument are lacking. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/bjs.11618DOI Listing

ASO Author Reflections: Targeting the Immunosuppressive Tumor Microenvironment for Treating Peritoneal Carcinomatosis of Gastrointestinal and Pancreaticobiliary Cancer.

Authors:
Carlos H F Chan

Ann Surg Oncol 2020 May 25. Epub 2020 May 25.

Department of Surgery, University of Iowa Hospitals and Clinics, University of Iowa, Iowa City, IA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1245/s10434-020-08640-1DOI Listing

Gastric cancer in young patients: a separate entity with aggressive features and poor prognosis.

J Cancer Res Clin Oncol 2020 May 25. Epub 2020 May 25.

Digestive Disease Center, Seventh Affiliated Hospital, Sun Yat-Sen University, 628 Zhenyuan Road, Shenzhen, 518107, China.

Purpose: To investigate the clinicopathological features and survival outcomes between young and old patients with gastric cancer (GC), and further determine the role of young age in the prognosis of GC.

Methods: Patients with stage I-III gastric adenocarcinomas undergoing curative surgery were enrolled, divided into young (aged 18-49 years, YG), middle-aged (50-59 years, MG), and old (≥ 60 years, OG) groups. Exclusion criteria were neoadjuvant therapy and history of malignant tumors. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00432-020-03268-wDOI Listing

ERS/ESTS/EACTS/ESTRO guidelines for the management of malignant pleural mesothelioma.

Eur Respir J 2020 May 25. Epub 2020 May 25.

Dept of Radiation Oncology, Kantonsspital St Gallen, St Gallen, Switzerland.

The European Respiratory Society (ERS)/European Society of Thoracic Surgeons (ESTS)/European Association for Cardio-Thoracic Surgery (EACTS)/European Society for Radiotherapy and Oncology (ESTRO) task force brought together experts to update previous 2009 ERS/ESTS guidelines on management of malignant pleural mesothelioma (MPM), a rare cancer with globally poor outcome, after a systematic review of the 2009-2018 literature. The evidence was appraised using the Grading of Recommendations, Assessment, Development and Evaluation approach. The evidence syntheses were discussed and recommendations formulated by this multidisciplinary group of experts. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1183/13993003.00953-2019DOI Listing

USEFUL PELVIC RETROPERITONEAL NEURO-ANATOMY FOR BENIGN GYNECOLOGIC SURGERY - A CADAVERIC DISSECTION.

J Minim Invasive Gynecol 2020 May 22. Epub 2020 May 22.

Department of Gynecological Surgery, Vita Batel Hospital, Curitiba, Brazil.

Objective: Knowledge of retroperitoneal anatomy is particularly important in order to facilitate the surgical procedure and reduce the number of complications. The objective of this video is to demonstrate pelvic neuroanatomical structures and their relationships in the pelvic side wall and the presacral space in a laparoscopic cadaveric dissection.

Design: Case report (anatomical study). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jmig.2020.05.013DOI Listing

Peritoneal Flap in Robot-Assisted Radical Prostatectomy.

Dtsch Arztebl Int 2020 Apr;117(14):243-250

Department of Urology, University of Regensburg, Caritas St. Josef Medical Center, Regensburg, Germany; Department of Urology and Andrology, Hospital of St. John of God (Krankenhaus der Barmherzigen Brüder Wien), Vienna, Austria; Department of Urology and Andrology, Paracelsus Medical University Salzburg, Salzburg, Austria; Department of Urology, St. Elisabeth Hospital Straubing, Straubing, Germany; Department of Urology, Vivantes Humboldt Hospital Berlin, Berlin Germany; These two authors are co-first authors.

Background: Lymphocele is the most common complication arising after pelvic lymph node dissection (PLND) in the setting of robot-assisted radical prostatectomy (RARP). The only data available until now on the utility of a peritoneal flap to prevent lymphocele were retrospectively acquired.

Methods: A randomized, controlled, multi-center trial with blinded assessment of endpoints was carried out on 232 patients with prostate cancer who underwent RARP with PLND. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3238/arztebl.2020.0243DOI Listing

Clinicopathologic characteristics and survival of patients with primary effusion lymphoma.

Leuk Lymphoma 2020 May 25:1-10. Epub 2020 May 25.

Dana-Farber Cancer Institute, Harvard Medical School, Boston, USA.

Primary effusion lymphoma (PEL) is an aggressive B-cell lymphoma confined to body cavities and universally associated with human herpesvirus type 8 infection. The prognosis of this entity remains poor, with a median survival time of 6 to 9 months. To better understand the clinicopathologic features of the disease and identify possible prognostic factors, we performed a systematic review of the literature for cases of PEL, including 2 previously unreported cases from our institution. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/10428194.2020.1762881DOI Listing