Search Our Scientific Publications & Authors

Eur J Radiol 2019 May 15;114:146-151. Epub 2019 Mar 15.

Department of Radiology, The Netherlands Cancer Institute, PO Box 900203, 1006 BE, Amsterdam, the Netherlands. Electronic address:

Objectives: To determine the diagnostic performance of MRI with diffusion-weighted imaging (DW-MRI) in assessing the peritoneal tumor load and predicting whether a complete cytoreduction can be achieved in patients with epithelial ovarian cancer (EOC).

Methods: For this observational prospective study, 25 patients with epithelial ovarian cancer scheduled for cytoreductive surgery were included. Patients underwent a 3 T DW-MRI scan prior to surgery. Read More

J Surg Res 2019 Apr 17;241:31-39. Epub 2019 Apr 17.

Division of Surgical Oncology, Department of Surgery, The Ohio State University Wexner Medical Center, Columbus, Ohio. Electronic address:

Background: Formal gastrectomy is occasionally required to achieve complete cytoreduction for patients with peritoneal surface malignancies. In addition, the role of cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) for patients with gastric cancer is increasingly being explored. Nevertheless, data on the safety of gastrectomy at the time of CRS-HIPEC are limited. Read More

J Emerg Med 2019 Apr 16. Epub 2019 Apr 16.

Department of Emergency Medicine, Cincinnati Children's Hospital and Medical Center, Cincinnati, Ohio; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio.

Background: Most pediatric patients with lymphoma do not have classic symptoms of fever, night sweats, and weight loss. Lymphoma can present as vague symptoms and may mimic common pediatric abdominal emergencies. In this case report, we present a child who presented with abdominal pain and who was initially misdiagnosed as having a surgical emergency. Read More

Eur J Surg Oncol 2019 Apr 1. Epub 2019 Apr 1.

Department of Urology, The Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands. Electronic address:

Introduction: Urachal adenocarcinoma (UrAC) is a rare malignancy arising from persistent urachal remnants, which can cause peritoneal metastases (PM). Currently, patients with this stage UrAC are considered beyond cure. Our objective is to report long-term oncological outcome after cytoreductive surgery (CRS) plus hyperthermic intraperitoneal chemotherapy (HIPEC) for patients with PM of urachal adenocarcinoma (UrAC). Read More

Gynecol Obstet Fertil Senol 2019 Apr 16. Epub 2019 Apr 16.

Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges-Pompidou, Chirurgie Cancérologique Gynécologique et du Sein, Paris, France; Université Paris Descartes, INSERM UMR-S 747, Paris, France; Université Paris Descartes, Sorbonne Paris Cité, Faculté de Médecine, Paris, France. Electronic address:

Objectives: Lynch syndrome (LS) is a hereditary predisposition to cancers, first of all, colo-rectal and endometrial cancers in women. Although recommended, gynecologic screening has never proven its benefit. Prophylactic surgery can be consider once the parental project is completed. Read More

Front Immunol 2019 3;10:691. Epub 2019 Apr 3.

The First Department of Gynecologic Oncology and Gynecology, Medical University of Lublin, Lublin, Poland.

Myeloid-derived suppressor cells (MDSCs) expansion is a hallmark of cancer. Three major MDSC subsets defined as monocytic (M)-MDSCs, polymorphonuclear (PMN)-MDSCs and early stage (e)MDSCs can be revealed in human diseases. However, the clinical relevance and immunosupressive pattern of these cells in epithelial ovarian cancer (EOC) are unknown. Read More

Br J Cancer 2019 Apr 19. Epub 2019 Apr 19.

Department of Surgical Oncology, The University of Tokyo, Tokyo, Japan.

Background: The aim of this study was to clarify whether a cancer stem cell marker could be an indicator of post-operative peritoneal recurrence of colon cancer.

Methods: Expression of four putative markers (CD133, CD44 variant 6, aldehyde dehydrogenase-1 and leucine-rich repeating G-protein-coupled receptor-5 (LGR5)) was evaluated immunohistochemically in primary tumour samples from 292 patients who underwent curative resection for non-metastasised pT4 colon cancer at the University of Tokyo Hospital between 1997 and 2015.

Results: Peritoneal recurrence was significantly higher in LGR5-negative cases (5-year cumulative incidence: 27. Read More

Ann Surg 2019 Apr 13. Epub 2019 Apr 13.

Department of Surgery, University of Calgary, Calgary, Alberta, Canada.

Objective: To determine the effect of bile spillage during cholecystectomy on oncological outcomes in incidental gallbladder cancers.

Background: Gallbladder cancer (GBC) is rare, but lethal. Achieving complete resection offers the best chance of survival. Read More

Clin Case Rep 2019 Apr 18;7(4):829-831. Epub 2019 Mar 18.

Department of Family Medicine Kaweah Delta Medical Center Visalia California.

can be misidentified as , due to similar biochemical properties. Automated identification systems and mass spectrometry play a very critical role in isolating atypical organisms like . General guidelines recommend treating peritonitis for 3 weeks without removal of peritoneal dialysis catheter. Read More

J Gastrointest Cancer 2019 Apr 16. Epub 2019 Apr 16.

Surgical Oncology, Euromedica Kyanous Stavros, Thessaloniki, Greece.

Ann Surg Oncol 2019 Apr 15. Epub 2019 Apr 15.

The Christie NHS Foundation Trust, Colorectal and Peritoneal Oncology Centre, Manchester, UK.

Introduction: Cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) is an established treatment for pseudomyxoma peritonei resulting from a perforated low-grade appendiceal mucinous neoplasm (LAMN II). In patients with localized disease, a laparoscopic procedure (L-CRS/HIPEC) can be undertaken.

Methods: This video demonstrates L-CRS/HIPEC in a 66-year-old male who had previously undergone an appendicectomy for an LAMN II lesion. Read More

Radiol Case Rep 2019 Jun 30;14(6):708-710. Epub 2019 Mar 30.

Department of Radiology, Madigan Army Medical Center, 9040A Jackson Avenue, Joint Base Lewis-McChord, WA 98431, USA.

Chylous leaks are an uncommon complication in patients undergoing surgical procedures with the majority of cases responding to conservative therapies. Described is a case of a 23-year-old male who developed debilitating refractory chylous ascites as a complication after retroperitoneal lymph node dissection for testicular cancer. Prior to being evaluated by interventional radiology, he required weekly large-volume paracentesis in addition to standard conservative therapies. Read More

Am J Surg 2019 Apr 1. Epub 2019 Apr 1.

Hepatobiliary and Surgical Oncology Unit, Department of Surgery, St George Hospital, Kogarah, NSW, Australia; St George Hospital Clinical School, University of New South Wales, Sydney, NSW, Australia. Electronic address:

Background: Peritoneal cancer index (PCI) is an important prognostic factor in colorectal cancer peritoneal metastases (CRPM), however it fails to consider the time period over which disease burden develops. The volume-time index (VTI) is the ratio between PCI and time from primary tumour resection.

Methods: A retrospective cohort study of 182 patients managed from 1996 to 2017 was performed. Read More

Cancer Chemother Pharmacol 2019 Apr 13. Epub 2019 Apr 13.

Breast and Medical Oncology, National Cancer Center Hospital, Tokyo, Japan.

Background/objective: Platinum-refractory or -resistant ovarian cancer (PRROC) is associated with poor prognosis and low response to further chemotherapy. We investigated predictors of effectiveness of following treatments for PRROC.

Patients And Methods: We included 380 patients diagnosed with stage I-IV ovarian, fallopian tube, or primary peritoneal cancer, who were treated at the National Cancer Center Hospital in Japan from January 2007 to December 2014 and recurred after initial treatment, who had a platinum-refractory or -resistant relapses and received chemotherapy, in this single-center, retrospective study. Read More

Colorectal Dis 2019 Apr 12. Epub 2019 Apr 12.

Cirugía Colorrectal, Servicio de Cirugía General y Aparato Digestivo, Hospital Universitario Marques de Valdecilla, Santander, Cantabria, Spain.

The surgical technique in the right colon cancer, is still not well standardized and many surgeons perform vessel ligation at different levels with not a clear idea of what type of lymphadenectomy we are actually doing. However, recent studies argue that a complete mesocolon excision (CME) with a true ligation of the vessels at the origin may reduce local recurrence rate, achieving consequently a higher overall survival and cancer related 5-year survival[1]. The reason for this may be that prserving the integrity of the specimen reduces tears that could cause peritoneal dissemination. Read More

Ann Surg Oncol 2019 Apr 11. Epub 2019 Apr 11.

Division of Surgical Oncology, Koch Regional Perfusion Center, University of Pittsburgh, Pittsburgh, PA, USA.

In the original article, the Comprehensive Complication Index (CCI) was incorrectly identified as the Comprehensive Comorbidity Index. Wherever CCI appears, it refers to the Comprehensive Complication Index. Read More

Proc Natl Acad Sci U S A 2019 Apr 11. Epub 2019 Apr 11.

Section of Hematology/Oncology, Department of Medicine, University of Chicago, Chicago, IL 60637.

Survival from malignant mesothelioma, particularly pleural mesothelioma, is very poor. For patients with breast, ovarian, or prostate cancers, overall survival is associated with increased sensitivity to platinum chemotherapy due to loss-of-function mutations in DNA repair genes. The goal of this project was to evaluate, in patients with malignant mesothelioma, the relationship between inherited loss-of-function mutations in DNA repair and other tumor suppressor genes and overall survival following platinum chemotherapy. Read More

Gut Liver 2019 Apr 11. Epub 2019 Apr 11.

Department of Internal Medicine, Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, South Korea.

Background/aims: : The benefit of second-line chemotherapy (SL) after failed first-line chemotherapy(FL) in patients with advanced pancreatic cancer has not yet been established. We evaluated the clinicalcharacteristics affecting the benefits of SL therapy compared to basic supportive care (BSC), identifiedthe prognostic factors, and ultimately devised a model of clinical parameters to assist in making decisionbetween SL and BSC after the failure of gemcitabine-based FL.

Methods: : The records of patients whoreceived gemcitabine-based FL for advanced pancreatic cancer at Yonsei University Hospital betweenJanuary 2010 and December 2015 were retrospectively reviewed. Read More

J Urol 2019 Apr;201(Suppl 4):e284

Essen, Germany.

Introduction And Objectives: In prostate cancer, radioguided surgery (RGS) is used for sentinel node biopsy (SNB) and holds potential for 99mTc-PSMA-guided surgery of lymph node metastases. Rigid laparoscopic gamma probes currently used for (robot-assisted) laparoscopic RGS procedures have limited manoeuvrability and control which restricts nodal identification. To address this a tethered laparoscopic gamma probe was developed (Lightpoint Medical Ltd). Read More

Nihon Shokakibyo Gakkai Zasshi 2019 ;116(4):336-343

Department of Surgery, Tane General Hospital.

A 69-year-old man was brought to our hospital's emergency room with a chief complaint of hematemesis, which had been caused by advanced gastric cancer on the lesser curvature of the stomach's upper body. Subsequently, total gastrectomy with lymph node dissection (D2) was performed. A pathological diagnosis of gastric adenocarcinoma, U, Less, type 2, 100×70mm, tub2, pT3, int, INFb, ly0, v0, pN0 (0/24), pPM0 (30mm), pDM0 (30mm), fStage IIA, was then established. Read More

Gut Liver 2019 Feb 27. Epub 2019 Feb 27.

Division of Gastroenterology, Department of Internal Medicine, Incheon St. Mary's Hospital, The Catholic University of Korea, Seoul, Korea.

Background/aims: The risk of peritoneal seeding following perforation after endoscopic resection in patients with early gastric cancer is unclear. The purpose of this study was to investigate long-term clinical outcomes including peritoneal seeding and overall survival rate following gastric perforation during endoscopic submucosal dissection (ESD).

Methods: Between January 2002 and March 2015, 556 patients were diagnosed with early gastric cancer and underwent ESD. Read More

Acta Haematol 2019 Apr 10;142(1):44-50. Epub 2019 Apr 10.

Nephrology and Hypertension Unit, Rabin Medical Center, Petah Tikva, Israel.

Iron deficiency anemia is a common complication of chronic kidney disease (CKD). CKD patients suffer from both absolute and functional iron deficiency. Absolute iron deficiency is defined by severely reduced or absent iron stores, while functional iron deficiency is defined by adequate iron stores but insufficient iron availability for incorporation into erythroid precursors. Read More

Monoclon Antib Immunodiagn Immunother 2019 Apr 10. Epub 2019 Apr 10.

1 Department of Antibody Drug Development, Tohoku University Graduate School of Medicine, Sendai, Japan.

Cancer stem cells contribute to tumorigenesis, metastasis, recurrence, and chemoresistance. CD133/prominin-1-a pentaspan membrane glycoprotein-has been used as a stem cell biomarker for the isolation of stem-like cells from a variety of normal and pathological tissues. In our previous studies, we developed several anti-CD133 monoclonal antibodies using Cell-Based Immunization and Screening (CBIS) methods, followed by characterization of their efficacy by flow cytometry, western blotting, and immunohistochemical analyses. Read More

J Cell Biochem 2019 Apr 10. Epub 2019 Apr 10.

Department of Pharmacogenomics, School of Pharmacy, Fourth Military Medical University, Xi'an, Shaanxi, China.

To determine the correlation between QKI and pancreatic cancer tissues, the QKI expression of pancreatic cancer cells and fibroblasts in the tumor-surrounding microenvironment were detected. Then, QKI overexpression and interference with QKI short hairpin RNA in LX-2 (a fibroblast cell line) were established in vitro. Meanwhile, to observe the cell proliferation, invasion, migration, and other changes, QKI, and related epithelial-mesenchymal transition (EMT) molecules were detected by a polymerase chain reaction and Western blot analysis. Read More

Clin Cancer Res 2019 Apr 9. Epub 2019 Apr 9.

Department of Medicine, University of Padua.

Purpose BRAF mutations are grouped in activating RAS-independent signaling as monomers (class 1 - V600E) or as dimers (class 2 - codons 597/601), and RAS-dependent with impaired kinase activity (class 3 - codons 594/596). While clinical, pathological and molecular features of V600E BRAF mutated metastatic colorectal cancer (mCRC) are well known, limited data are available from the two other classes. Experimental Design Data from 117 BRAF (92 class 1, 12 class 2, and 13 class 3) mutated mCRC patients were collected. Read More

J Pediatr Adolesc Gynecol 2019 Apr 6. Epub 2019 Apr 6.

Department of Obstetrics and Gynecology, Dokkyo Medical University Saitama Medical Center, Koshigaya Japan.

Background: Epithelial ovarian cancer development before menarche is extremely rare.

Case: We report a prepubertal girl who developed ovarian mucinous carcinoma with mural carcinosarcomatous components.

Summary And Conclusion: Magnetic resonance imaging showed a polycystic mass with solid components. Read More

Dis Colon Rectum 2019 May;62(5):639-641

Department of Gastrointestinal Surgery, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.

Introduction: Previous studies on total mesorectal excision suggested dissection anterior to Denonvilliers' fascia, which might lead to intraoperative pelvic autonomic nerves injury and a high incidence of urogenital dysfunction.

Technique: We dissected 4 cases of cadavers, mainly focusing on anatomy of Denonvilliers' fascia, to study the relationship between Denonvilliers' fascia and rectum. In practice, instead of dissection 1 cm above peritoneal reflection, dissection of the peritoneum was performed at the lowest level of peritoneal reflection during laparoscopic resection for mid-low rectal cancer. Read More

Ann Surg Oncol 2019 Apr 8. Epub 2019 Apr 8.

Division of Surgical Oncology, Department of Surgery, University of Tennessee Health Science Center, Memphis, TN, 38163, USA.

Background: Desmoplastic small round cell tumor (DSRCT) is a rare intra-abdominal soft tissue sarcoma affecting adolescents and young adults. Cytoreduction, hyperthermic intraperitoneal chemotherapy (CRS/HIPEC), and adjuvant radiotherapy may improve local control. We review our experience with patients who undergo CRS/HIPEC and adjuvant radiotherapy for DSRCT. Read More

Surg Today 2019 Apr 8. Epub 2019 Apr 8.

Department of Gastroenterological Surgery, Aichi Cancer Center Hospital, 1-1, Kanokoden, Chikusa, Nagoya, 464-8681, Aichi, Japan.

Purpose: This study aimed to clarify the prognosis of patients after resection of stage IV colorectal cancer and synchronous peritoneal metastasis (no residual disease: R0 status) based on histopathologic findings.

Methods: The subjects of this study were 26 patients who underwent radical resection of synchronous peritoneal metastases of stage IV colorectal cancer. Only patients with one synchronous peritoneal metastasis were included in this study. Read More

Cancer Manag Res 2019 20;11:2261-2267. Epub 2019 Mar 20.

Eli Lilly and Company, Taipei, Taiwan.

Purpose: Second-line treatment with ramucirumab-paclitaxel has demonstrated statistically significant and clinically meaningful survival outcomes compared to paclitaxel-alone in patients with advanced gastric cancer (HR=0.807, 95% CI 0.678-0. Read More

Pathol Res Pract 2019 Apr 3. Epub 2019 Apr 3.

Department of Pathology, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea; Cancer Evolution Research Center, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea. Electronic address:

Brain metastasis from ovarian/peritoneal cancer is a rare disease that has a dismal prognosis. And genomic alterations and immune-profiling in primary ovarian/ peritoneal cancer and brain metastatic tumor tissues have not been fully elucidated. Multiplexed immunofluorescence and whole-exome sequencing of two matched brain metastatic tumor and primary ovarian/peritoneal cancer tissues were performed. Read More

J Vis Exp 2019 Mar 25(145). Epub 2019 Mar 25.

Department of Radiology, Memorial Sloan Kettering Cancer Center; Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center; Center for Molecular Imaging and Nanotechnology (CMINT), Memorial Sloan Kettering Cancer Center; Gerstner Sloan Kettering Graduate School of Biomedical Sciences; Department of Radiology, Weill Cornell Medical College of Cornell University; Dana-Farber Cancer Institute and Harvard Medical Center;

Ovarian cancer represents the deadliest gynecologic malignancy. Most patients present at an advanced stage (FIGO stage III or IV), when local metastatic spread has already occurred. However, ovarian cancer has a unique pattern of metastatic spread, in that tumor implants are initially contained within the peritoneal cavity. Read More

BJS Open 2019 Apr 27;3(2):195-202. Epub 2018 Sep 27.

Department of Digestive Surgery, Centre Hospitalier Lyon Sud, Université Claude Bernard Lyon 1, Lyon, France.

Background: Pseudomyxoma peritonei (PMP) is a rare clinical condition characterized by mucinous ascites, typically related to appendiceal or ovarian tumours. Current standard treatment involves cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC), but recurrences occur in 20-30 per cent of patients. The aim of this study was to define the timing and patterns of recurrence to provide a basis for modifying follow-up of these patients. Read More

Eur J Surg Oncol 2019 Mar 29. Epub 2019 Mar 29.

Program in Peritoneal Surface Oncology, Washington Cancer Institute, Washington, DC, USA.

Background: Peritoneal surfaces are a common site for the dissemination of gastrointestinal and gynecologic malignancy. Often, the surgeon can achieve a complete response. Unfortunately, current perioperative chemotherapy regimens fail to maintain control of cancer nodules within the abdomen and pelvis. Read More

Eur J Surg Oncol 2019 Mar 29. Epub 2019 Mar 29.

Service de gynécologie, CHI Poissy, France.

Eur J Surg Oncol 2019 Mar 23. Epub 2019 Mar 23.

Department of Surgery, Peritoneal Surface Malignancy Unit, Fondazione IRCCS Istituto Nazionale Dei Tumori di Milano, Via Giacomo Venezian 1, Milano, Milan Cap, 20133, Italy. Electronic address:

Pseudomyxoma Peritonei (PMP) and Peritoneal Mesothelioma (PM) are both rare peritoneal malignancies. Currently, affected patients may be treated with Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy offering long-term survival or even cure in selected patients. However, many issues regarding the optimal treatment strategy are currently under debate. Read More

Cancer Epidemiol 2019 Apr 3;60:106-111. Epub 2019 Apr 3.

INSERM U1086 « ANTICIPE », Caen University, F-14000, Caen, France; Occupational Diseases Department, University Hospital, Caen, F-14033, France.

Background: Peritoneal malignant mesothelioma is a rare disease for which few population-based studies are available. The aim of this study was to describe the evolution of the incidence and survival of peritoneal malignant mesothelioma in France between 1989 and 2015, using data derived from the French network of cancer registries.

Methods: Age world-standardized incidence rates and overall survival were calculated using data from 16 French cancer registries. Read More

J Immunol 2019 Apr 5. Epub 2019 Apr 5.

Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215;

Biliverdin reductase (BVR)-A is a pleotropic enzyme converting biliverdin to bilirubin and a signaling molecule that has cytoprotective and immunomodulatory effects. We recently showed that biliverdin inhibits the expression of complement activation fragment 5a receptor one (C5aR1) in RAW 264.7 macrophages. Read More

Int J Surg Case Rep 2019 Mar 21;57:118-121. Epub 2019 Mar 21.

Department of Surgery, University of Modena and Reggio Emilia - Policlinico of Modena, Via del Pozzo, 71, 41100 Modena, Italy. Electronic address:

Introduction: Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) is nowadays a feasible and effective treatment for peritoneal metastasis. We present a case of a 14 years old child with peritoneal metastasis from recurrent colorectal cancer.

Presentation Of Case: Colonoscopy and CT-scan were performed leading to the diagnosis of a stenosing adenocarcinoma of the right colon in 2015. Read More

Cancer Cell Int 2019 22;19:69. Epub 2019 Mar 22.

Department of Surgery, Shanghai Key Laboratory of Gastric Neoplasms, Shanghai Institute of Digestive Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025 People's Republic of China.

Background: Gastric cancer (GC) has a clear predilection for metastasis toward omentum which is primarily composed of adipose tissue, combine with our previous research that long non-coding RNA Urothelial cancer associated 1 (UCA1) could promote the peritoneal metastasis of GC, we put forward the hypothesis that fatty acids (FAs) might contribute to these phenomena and a connection between FAs and UCA1 might exist.

Methods: TCGA database was applied to investigate the expression levels of UCA1 in GC tissues and normal gastric tissues and its correlation with GC patients' survival. Transfection of siRNA was utilized to knockdown cellular levels of FA-binding protein 5 (FABP5), SP1, UCA1. Read More

Indian J Surg Oncol 2019 Mar 3;10(1):3-23. Epub 2019 Jan 3.

Center for Gastrointestinal Malignancies, MedStar Washington Hospital Center, 106 Irving St., NW, Suite 3900, Washington, DC 20010 USA.

Peritoneal metastases may occur from a majority of cancers that occur within the abdomen or pelvis. When cancer spread to the peritoneal surfaces is documented, a decision regarding palliation versus an aggressive approach using cytoreductive surgery (CRS) and hyperthermic perioperative intraperitoneal chemotherapy (HIPEC) must be made. This decision is dependent on a well-defined group of prognostic indicators. Read More

Lancet Oncol 2019 Apr 1. Epub 2019 Apr 1.

Division of Gynecologic Oncology, Arizona Oncology (US Oncology Network), University of Arizona College of Medicine, Creighton University School of Medicine at St Joseph's Hospital, Phoenix, AZ, USA.

Background: Late-line treatment options for patients with ovarian cancer are few, with the proportion of patients achieving an overall response typically less than 10%, and median overall survival after third-line therapy of 5-9 months. In this study (QUADRA), we investigated the activity of niraparib monotherapy as the fourth or later line of therapy.

Methods: QUADRA was a multicentre, open-label, single-arm, phase 2 study that evaluated the safety and activity of niraparib in adult patients (≥18 years) with relapsed, high-grade serous (grade 2 or 3) epithelial ovarian, fallopian tube, or primary peritoneal cancer who had been treated with three or more previous chemotherapy regimens. Read More

Eur J Surg Oncol 2019 Mar 9. Epub 2019 Mar 9.

NPO to Support Peritoneal Dissemination Treatment, Osaka, Japan; Peritoneal Dissemination Center, Kishiwada Tokushukai Hospital, Kishiwada, Japan; Department of Surgery, Kusatsu Genaral Hospital, Shiga, Japan. Electronic address:

Purpose: The aim of the present study was to evaluate the clinical features and prognosis of lymph node metastasis (LNM) in gastric cancer patients with peritoneal metastasis (PM) after neoadjuvant intraperitoneal and systemic chemotherapy.

Methods: A total of 69 gastric cancer patients with PM and LNM who received neoadjuvant intraperitoneal and systemic chemotherapy (NIPS) of intraperitoneal docetaxel (DXT) and cisplatin (CDDP); intravenous chemotherapy of DXT and CDDP and oral S-1in Kishiwada Tokushukai Hospital between January 2008 and February 2017. After surgical resection, the response of LNMs was studied to confirm the effect of NIPS on LNMs. Read More

Eur J Med Chem 2019 Jun 20;172:62-70. Epub 2019 Mar 20.

Department of Gynaecology and Obstetrics, The Second Hospital of Jilin University, Changchun, Jilin, 130041, China. Electronic address:

In the present study a library of thiophenol-formaldehyde-triazole (TFT) derivatives was synthesized and screened against CAOV3, CAOV4 and ES-2 ovary cancer cell lines. Initial screening revealed that five-compounds 5a, 5b, 5j, 5h and 5i inhibited the viability of tested cell lines. Analysis of apoptosis revealed that increase in compound 5a (most active) concentration from 0. Read More

J Gastric Cancer 2019 Mar 12;19(1):102-110. Epub 2019 Mar 12.

Department of Surgery, Seoul National University Bundang Hospital, Seongnam, Korea.

Purpose: Despite an increased acceptance of laparoscopic gastrectomy (LG) in early gastric cancer (EGC), there is insufficient evidence for its oncological safety in advanced gastric cancer (AGC). This is a prospective phase II clinical trial to evaluate the feasibility of LG with D2 lymph node dissection (LND) in AGC.

Materials And Methods: The primary endpoint was set as 3-year disease-free survival (DFS). Read More

Radiat Oncol 2019 Apr 3;14(1):57. Epub 2019 Apr 3.

Department of Clinical Oncology, Velindre Cancer Centre, Velindre Road, Whitchurch, Cardiff, CF14 2TL, UK.

Background: Advanced pelvic radiotherapy techniques aim to reduce late bowel toxicity which can severely impact the lives of pelvic cancer survivors. Although advanced techniques have been largely adopted worldwide, to achieve their aim, knowledge of which dose-volume parameters of which components of bowel predict late bowel toxicity is crucial to make best use of these techniques. The rectum is an extensively studied organ at risk (OAR), and dose-volume predictors of late toxicity for the rectum are established. Read More

N Engl J Med 2019 04;380(14):1386

Int J Mol Med 2019 Mar 29. Epub 2019 Mar 29.

Department of Anesthesiology and Pain Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, P.R. China.

The identification of the expression patterns of long non‑coding RNAs (lncRNAs) and mRNAs in the spinal cord under normal and cardiac ischemia/reperfusion (I/R) conditions is essential for understanding the genetic mechanisms underlying the pathogenesis of cardiac I/R injury. The present study used high‑throughput RNA sequencing to investigate differential gene and lncRNA expression patterns in the spinal cords of rats during I/R‑induced cardiac injury. Male Sprague Dawley rats were assigned to the following groups: i) Control; ii) 2 h (2 h post‑reperfusion); and iii)v0. Read More

Sci Rep 2019 Apr 2;9(1):5515. Epub 2019 Apr 2.

Edinburgh Cancer Research Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Crewe Road South, Edinburgh, EH4 2XR, UK.

The term ovarian cancer describes a heterogeneous group of tumours that grow in the ovary but are not necessarily of ovarian origin. Recent genomic analysis has shown that many of the most commonly used ovarian cancer cell lines have been mischaracterised, leading to erroneous conclusions and a gap in the translation of laboratory research into novel treatments for patients. Here, we use 10 epithelial ovarian cancer cell lines to investigate 2D migration, cell cycle parameters and 3D invasion behaviour into different substrates and find significant differences between the behaviours of cell lines from different origins. Read More

J Biol Chem 2019 Apr 2. Epub 2019 Apr 2.

Faculty of Biology Medicine and Health, University of Manchester, United Kingdom.

Interleukin (IL)-1-family cytokines potently regulate inflammation, with the majority of the IL-1 family proteins being secreted from immune cells via unconventional pathways. In many cases, secretion of IL-1 cytokines appears to be closely coupled to cell death, yet the secretory mechanisms involved remain poorly understood. Here, we studied the secretion of the three best characterized members of the IL-1 super-family, IL-1α, IL-1β, and IL-18, in a range of conditions and cell types, including murine bone marrow derived and peritoneal macrophages, human monocyte derived macrophages, HeLa cells, and mouse embryonic fibroblasts. Read More