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Clin Exp Nephrol 2018 Dec 13. Epub 2018 Dec 13.

Department of Nephrology and Rheumatology, Aichi Medical University, 1-1 Yazakokarimata, Nagakute, Aichi, 480-1195, Japan.

Background: The morphological changes induced by bio-incompatible peritoneal dialysis (PD) solutions are well known. However, the morphological damage induced by long-term low-glucose degradation product (GDP), pH-neutral solutions has not been reported in detail. The aim of this study was to investigate the long-term effects of pH-neutral PD solutions on morphological and functional changes in the peritoneal membrane. Read More

Surg Case Rep 2018 Dec 13;4(1):143. Epub 2018 Dec 13.

Department of General surgery, Redcliffe Hospital, Redcliffe, QLD, 4020, Australia.

Background: Femoral hernia accounts for 3% of all the hernias, and in 0.5-5% of cases, the appendix can migrate through the femoral hernia and is called de Garengeot hernia. It is a very rare condition, and the incidence of appendicitis in this type of hernia is as low as 0. Read More

Glob Pediatr Health 2018 4;5:2333794X18816920. Epub 2018 Dec 4.

The Children's Mercy Hospitals and Clinics, Kansas City, MO, USA.

. Hemolytic uremic syndrome (HUS) is one of the common causes for acute kidney injury in childhood. . Read More

Oncoimmunology 2019 6;8(1):e1515058. Epub 2018 Sep 6.

Vaccine and Immunotherapy Center, The Wistar Institute, Philadlephia, PA, USA.

Ovarian cancer is frequently diagnosed as peritoneal carcinomatosis. Unlike other tumor locations, the peritoneal cavity is commonly exposed to gut-breaching and ascending genital microorganisms and has a unique immune environment. IL-33 is a local cytokine that can activate innate and adaptive immunity. Read More

Mol Clin Oncol 2018 Dec 4;9(6):651-655. Epub 2018 Oct 4.

First Department of Pathology, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.

Neuroendocrine tumors (NETs), belong to a group of neoplasms that arise from neuroendocrine cells and express markers such as synaptophysin and chromogranin A. The digestive system (DS) is the most common site of NET development. The World Health Organization classification divides NETs into low grade (G1-G2) tumors (NETs) and high grade carcinomas [neuroendocrine carcinomas (NECs)], based on mitotic index and histological criteria. Read More

Exp Ther Med 2018 Dec 19;16(6):4602-4608. Epub 2018 Sep 19.

Department of Gastroenterology, Xijing Hospital of Digestive Diseases, State Key Laboratory of Cancer Biology and Institute of Digestive Diseases, Xi'an, Shaanxi 710000, P.R. China.

Despite significant developments in its clinical treatment, the reported incidence and mortality of gastric cancer have exhibited marked increases. The molecular mechanisms of gastric cancer initiation and progression remain to be fully elucidated. The aim of the present study was to identify novel microRNAs (miRNAs/miRs) with a role in the peritoneal metastasis of gastric cancer by comparing the miRNA expression in the gastric cancer cell line GC9811 with that in its variant GC9811-P, a sub-cell line with a high potential for peritoneal metastasis. Read More

Am J Case Rep 2018 Dec 14;19:1488-1494. Epub 2018 Dec 14.

Department of Digestive Surgery, Tenri Hospital, Tenri, Nara, Japan.

BACKGROUND Colostomy creation via intraperitoneal route is often performed during laparoscopic Hartmann's operation or abdominoperineal resection (APR). Herein, we report 3 rare cases of internal hernia associated with colostomy (IHAC). CASE REPORT The first case involved a 70-year-old man with IHAC after laparoscopic APR. Read More

Clin J Am Soc Nephrol 2018 Dec 13. Epub 2018 Dec 13.

Imperial College Renal and Transplant Centre, Hammersmith Hospital, London, UK

Clin J Am Soc Nephrol 2018 Dec 13. Epub 2018 Dec 13.

Nephrology Section, Department of Internal Medicine, Ghent University Hospital, Ghent, Belgium; and.

Background And Objectives: The prevalence of patients with ESKD who receive extracorporeal kidney replacement therapy is rising worldwide. We compared government reimbursement for hemodialysis and peritoneal dialysis worldwide, assessed the effect on the government health care budget, and discussed strategies to reduce the cost of kidney replacement therapy.

Design, Setting, Participants, & Measurements: Cross-sectional global survey of nephrologists in 90 countries to assess reimbursement for dialysis, number of patients receiving hemodialysis and peritoneal dialysis, and measures to prevent development or progression of CKD, conducted online July to December of 2016. Read More

Am J Kidney Dis 2018 Dec 10. Epub 2018 Dec 10.

Wake Forest School of Medicine, Winston-Salem, NC. Electronic address:

Home dialysis therapy, including home hemodialysis and peritoneal dialysis, is underused as a modality for the treatment of chronic kidney failure. The National Kidney Foundation-Kidney Disease Outcomes Quality Initiative sponsored a home dialysis conference in late 2017 that was designed to identify the barriers to starting and maintaining patients on home dialysis therapy. Clinical, operational, policy, and societal barriers were identified that need to be overcome to ensure that dialysis patients have the freedom to choose their treatment modality. Read More

Cell Immunol 2018 Dec 4. Epub 2018 Dec 4.

School of Biological Sciences, University of Wollongong, Wollongong, NSW 2252, Australia; Molecular Horizons, University of Wollongong, NSW 2252, Australia; Illawarra Health and Medical Research Institute, Wollongong, NSW 2252, Australia. Electronic address:

Allogeneic haematopoietic stem cell transplantation (HSCT) is a frequent curative therapy for numerous haematological malignancies. However, HSCT is limited by the occurrence of graft-versus-host disease (GVHD), with current therapies restricted to general immunosuppression. Activation of the P2X7 receptor by extracellular adenosine triphosphate (ATP) causes inflammation and tissue damage in GVHD. Read More

Taiwan J Obstet Gynecol 2018 Dec;57(6):830-835

Reproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran. Electronic address:

Objective: Silymarin as an herbal drug has potent antioxidant effects that could make it a good choice for endometriosis therapy. The aim of the current study was to determine the effects of silymarin as an herbal drug on induced endometrial lesion in rat model of endometriosis.

Materials And Methods: A total of 32 mature, female Sprague-Dawley rats were allocated into 4 experimental groups. Read More

Lipids Health Dis 2018 Dec 13;17(1):285. Epub 2018 Dec 13.

Genomics and Biomarkers Unit, National Institute for Health and Welfare, FI-00251, Helsinki, Finland.

Background: The focus of studies on high-density lipoproteins (HDL) has shifted from HDL-cholesterol (HDL-C) to HDL function. We recently demonstrated that low USF1 expression in mice and humans associates with high plasma HDL-C and low triglyceride levels, as well as protection against obesity, insulin resistance, and atherosclerosis. Here, we studied the impact of USF1 deficiency on HDL functional capacity and macrophage atherogenic functions, including inflammation, cholesterol efflux, and cholesterol accumulation. Read More

Int J Mol Sci 2018 Dec 9;19(12). Epub 2018 Dec 9.

Department of Microbiology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Tokyo 142-8501, Japan.

It has recently been recognized that inflammatory cytokines, such as tumor necrosis factor-α (TNF-α), upregulate the secretion of matrix metalloproteinase-9 (MMP-9) from cancer cells and thereby promote peritoneal dissemination. In this study, we found that TNF-α also stimulated peritoneal mesothelial cells to secrete MMP-9 as assessed by zymography. MMP-9 gene expression in mesothelial cells induced by TNF-α was confirmed by quantitative RT-PCR analysis. Read More

Molecules 2018 Dec 7;23(12). Epub 2018 Dec 7.

Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, 44883-2462 Heidelberg, Germany.

Reactive oxygen species (ROS) have been linked to several health conditions, among them inflammation. Natural antioxidants may attenuate this damage. Our study aimed to investigate the chemical composition of a methanol leaf extract from and its possible antioxidant, anti-inflammatory, anti-nociceptive, and antipyretic effects. Read More

Medicine (Baltimore) 2018 Dec;97(49):e13567

Emergency Department, Chi Mei Medical Center.

The standard treatment of peritoneal dialysis peritonitis (PD peritonitis) is intraperitoneal antibiotic therapy. In patients with PD peritonitis complicated by bacteremia, intraperitoneal antibiotics combined with elective removal of the infected intraperitoneal catheter may be inadequate.We collected data of all patients with PD peritonitis admitted to Chi-Mei Medical Center during a 4-year period. Read More

Medicine (Baltimore) 2018 Dec;97(49):e13525

Department of Surgery, 2nd Affiliated Hospital, Zhejiang University School of Medicine.

The objectives of this systematic review and pooled analysis were to examine long-term survival, morbidity, and mortality following thermal ablation of gastric cancer hepatic metastases and to identify prognostic factors that improve survival.Patients with hepatic metastases from gastric cancer are traditionally treated with palliative chemotherapy. Surgical resection is an alternative treatment of hepatic metastases. Read More

Medicine (Baltimore) 2018 Dec;97(49):e13520

Department of Gynecology and Obstetrics, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong, China.

Rationale: Reports of malignant ovarian tumor with hyperamylasemia are very rare. We present a patient with hyperamylasemia who was diagnosed with a malignant ovarian tumor.

Patient Concerns: A 46-year-old woman was hospitalized complaining of a 2-day history of abdominal discomfort and fever. Read More

Biol Reprod 2018 Nov 15. Epub 2018 Nov 15.

Department of Marine Biosciences, Tokyo University of Marine Science and Technology, Tokyo, Japan.

Many bitterling species are facing extinction because of habitat destruction. Since cryopreservation of fish eggs is still not available to date due to their large size and high yolk content, long-term and stable storage of bitterling genetic resources is currently not possible. We recently discovered that cryopreservation of early-stage germ cells is possible in several fish species and that functional gametes derived from the frozen materials can be produced through their transplantation to embryonic recipients. Read More

Updates Surg 2018 Dec 12. Epub 2018 Dec 12.

Department of Life, Health and Environmental Sciences, University of L'Aquila, L'Aquila, Italy.

The median overall survival of metastatic breast cancer (MBC) patients is still approximately 2 years. This is even lower in triple-negative breast cancer (TNBC) patients with concomitant lung metastases. These patients are often not suitable for surgery and not responsive to systemic chemotherapy. Read More

Front Pediatr 2018 27;6:356. Epub 2018 Nov 27.

Department of Cardiopulmonary Bypass, Chinese Academy of Medical Sciences and Peking Union Medical College Fuwai Hospital, Beijing, China.

With the widespread application of regional low-flow perfusion (RLFP), development of surgical techniques, and shortened circulatory arrest time, deep hypothermia is indispensable for organ protection. Clinicians have begun to increase the temperature to reduce hypothermia-related adverse outcomes. The aim of this study was to evaluate the safety and efficacy of elevated temperatures during aortic arch surgery with lower body circulatory arrest (LBCA) combined with RLFP. Read More

Exp Ther Med 2018 Dec 12;16(6):5265-5271. Epub 2018 Oct 12.

Department of Gastroenterology, Shenzhen People's Hospital, The Second Affiliated Hospital of Jinan University, Shenzhen, Guangdong 518020, P.R. China.

Laparoscopy with peritoneal biopsy is a tool for rapid and accurate diagnosis of tuberculous peritonitis (TBP). However, laparoscopic procedures are not risk-free; complications include injuries to the gastrointestinal tract and major blood vessels. The purpose of the present study was to introduce a novel method for safe and straightforward laparoscopic diagnosis of TBP. Read More

Exp Mol Med 2018 Dec 12;50(12):164. Epub 2018 Dec 12.

Department of Korean Medical Science, School of Korean Medicine, Seoul, Republic of Korea.

Endometriosis is a disease characterized by implants of endometrial tissue outside the uterine cavity and is strongly associated with infertility. Focal adhesion of endometrial tissue to the peritoneum is an indication of incipient endometriosis. In this study, we examined the effect of various cytokines that are known to be involved in the pathology of endometriosis on endometrial cell adhesion. Read More

Turk J Med Sci 2018 12 12;48(6):1141-1146. Epub 2018 Dec 12.

Department of Urology, Gaziosmanpaşa Taksim Education Hospital, İstanbul, Turkey

Background/aim: Intraperitoneal urinary system perforation is a rare but serious complication of endoscopic urologic surgery. Percutaneous placement of a peritoneal drainage catheter is already mainly used for diagnostic purposes. We present our experience with percutaneous drainage catheters for conservative management of intraperitoneal urinary system perforations occurring during endoscopic urologic surgery with close monitorization in selected cases. Read More

Adv Clin Exp Med 2018 Dec 7. Epub 2018 Dec 7.

Department of Endocrinology, Metabolism and Internal Diseases, Poznan University of Medical Sciences, Poland.

Background: The new polypeptide hormones adropin and irisin have a broad impact on human metabolism and energy homeostasis. They could be potential biomarkers of cardiac injury. In end-stage renal disease (ESRD), the clinical importance of adropin and irisin is yet to be investigated. Read More

Clin Kidney J 2018 Dec 25;11(6):881-888. Epub 2018 Jun 25.

Unidad de Investigación, Hospital Universitario de Gran Canaria Dr Negrín, Las Palmas de Gran Canaria, Gran Canaria, Spain.

Background: We have compared the effects of conventional lactate-based peritoneal dialysis fluid (CPDF) with respect to bicarbonate/lactate-based fluid on peritoneal ultrafiltration (UF) and peritoneal permeability, and on variations on gene expression in cells isolated from effluents of patients' peritoneal bags.

Methods: This was a non-randomized sequential prospective study including all incident peritoneal dialysis (PD) patients ( = 40) recruited in our centre. Peritoneal equilibration tests (PETs) were performed using CPDF or BPDF both containing 2. Read More

Clin Kidney J 2018 Dec 18;11(6):874-880. Epub 2018 Jul 18.

Department of Nephrology and Dialysis, Azienda Socio Sanitaria Territoriale di Monza, Desio, Italy.

Backgound: Fungal peritonitis (FP) is one of the most important causes of peritoneal dialysis (PD) failure, often burdened by increased morbility and mortality. This study evaluates the clinical course of FP cases that arose between 1983 and 2016 in a single PD unit.

Methods: We conducted a retrospective observational analysis of FP episodes recorded in the Baxter POET (Peritonitis Organism Exit sites Tunnel infections) registry and clinical records. Read More

Wideochir Inne Tech Maloinwazyjne 2018 Dec 30;13(4):542-545. Epub 2018 May 30.

Department of Digestive Surgery, Amiens University Hospital, Amiens, France.

Management of a perforated duodenal ulcer is most commonly performed by laparoscopy and consists of suture of the perforation after performing lavage of the peritoneal cavity. In most cases, a flap is created, and an omental flap is usually the preferred choice because of its simplicity and its proximity to the site of duodenal perforation. However, in some cases, the greater omentum cannot be used due to the severity of peritonitis or due to previous surgical removal. Read More

Front Immunol 2018 15;9:2650. Epub 2018 Nov 15.

Department of Biomedical Sciences, Center of Excellence for Inflammation, Infectious Disease and Immunity, Quillen College of Medicine, East Tennessee State University, Johnson City, TN, United States.

Chronic inflammation is essential mechanism during the development of cardiovascular and metabolic diseases. The outcome of diseases depends on the balance between the migration/accumulation of pro-inflammatory (M1) and anti-inflammatory (M2) macrophages in damaged tissue. The mechanism of macrophage migration and subsequent accumulation is still not fully understood. Read More

Front Physiol 2018 20;9:1643. Epub 2018 Nov 20.

REDINREN, Madrid, Spain.

The prevalence of low- turnover bone disease (LTBD) in peritoneal dialysis (PD) patients is higher than in hemodialysis (HD) patients. LTBD patients may be at risk for vascular calcification, and cardiovascular disease. Current therapy for chronic kidney disease metabolic bone disorders (CKD-MBD) is guided by biochemical parameters, as bone biopsy is not used in routine clinical care. Read More

Mediators Inflamm 2018 4;2018:7902841. Epub 2018 Nov 4.

Center for Vascular and Inflammatory Diseases, University of Maryland School of Medicine, Baltimore, MD 21201, USA.

Hepatic inflammation is associated with the development of insulin resistance, which can perpetuate the disease state and may increase the risk of metabolic syndrome and diabetes. Despite recent advances, mechanisms linking hepatic inflammation and insulin resistance are still unclear. The low-density lipoprotein receptor-related protein 1 (LRP1) is a large endocytic and signaling receptor that is highly expressed in macrophages, adipocytes, hepatocytes, and vascular smooth muscle cells. Read More

Tech Coloproctol 2018 Dec 6. Epub 2018 Dec 6.

Department of Surgery, Tulane University School of Medicine, 1430 Tulane Ave, #8622, New Orleans, LA, 70112, USA.

Ann Surg Oncol 2018 Dec 6. Epub 2018 Dec 6.

The Institute for Cancer Care, Mercy Medical Center, Baltimore, MD, USA.

Background: Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) is standard treatment for peritoneal dissemination from appendiceal cancer (AC); however, its role in high-grade histopathologic subtypes (high-grade mucinous carcinoma peritonei [HGMCP] and HGMCP with signet ring cells [HGMCP-S]) is controversial due to their aggressive behavior. This study analyzed clinical outcomes of high-grade AC after CRS/HIPEC.

Methods: A prospective database of CRS/HIPEC procedures for HGMCP performed from 1998-2017 was reviewed. Read More

Arch Gynecol Obstet 2018 Dec 7. Epub 2018 Dec 7.

Clinic for Gynaecology, Charité University of Medicine, Hindenburgdamm 30, 12203, Berlin, Germany.

Purpose: Superficial peritoneal endometriotic (pEM) lesions are composed of endometrial glands and stroma, in addition to a third component-myofibroblasts and smooth muscles (SM)-like cells. The latter develops secondary to a metaplasia. In this study, we characterised the third component cells in pEM according to differentiation markers in different micro-compartments. Read More

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2018 Oct;43(10):1159-1163

Department of Nephrology, Second Xiangya Hospital, Central South University; Hunan Key Laboratory of Kidney Disease and Blood Purifi cation, Changsha 410011, China.

Cofilin is a actin-binding protein in eukaryotic cells. It plays a role in maintaining the steady state of the internal environment through regulating actin dynamics, which contributes to the development of various kinds of diseases. In recent 20 years, cofilin has been widely attracted due to its regulatory effect on cell phenotype, gene transcription, apoptosis and inflammation in renal tissue. Read More

Asian J Surg 2018 Dec 3. Epub 2018 Dec 3.

Division of Colorectal Surgery, Department of Surgery, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan.

To clarify the anatomic concept of Toldt fascia, based on the literature review and the surgical anatomic dissection using laparoscopic or robotic approach. We undertook review of the historic literature and surgical videos from 250 patients with colorectal cancer operated on laparoscopically or robotically to discuss the surgical implications of Toldt fascia in complete mesocolic excision for colon cancer. Toldt fascia, sandwiched by the overlying mesothelial layer of the mesocolon and underlying mesothelial layer of the retroperitoneum, comprised loose fibrous tissues with minute vessels inside, and was contiguous from the ileocecal mesentery radix to the upper rectum. Read More

J Visc Surg 2018 Dec 3. Epub 2018 Dec 3.

Service de chirurgie digestive, centre hospitalier universtaire Amiens, avenue René-Laennec, 80054 Amiens cedex 01, France; Université Picardie-Jules-Verne, 1, chemin du Thil, 80000 Amiens cedex 01, France; Simplifications des soins patients chirurgicaux complexes, or Simplication of care of complex surgical patients (SSPC), unité de recherché clinique, université Picardie-Jules-Vernes, 80000 Amiens, France. Electronic address:

Pseudomyxoma peritonei is a rare tumor characterized by the presence of mucous disseminated throughout the peritoneal cavity generally arising from the rupture of an appendicular mucocele. Liver scalloping is a highly suggestive image of pseudomyxoma and corresponds to the indentation of the liver compressed by the gelatinous mucin. Read More

Int J Surg Pathol 2018 Dec 6:1066896918816815. Epub 2018 Dec 6.

1 Rashid Hospital, Dubai, UAE.

Multilocular peritoneal inclusion cysts are mesothelial tumor-like lesions with or without small foci of florid papillary mesothelial hyperplasia that might simulate serous epithelial papillary lesions or well-differentiated papillary mesothelioma (WDPM) of the peritoneum. The papillary cores in papillary mesothelial hyperplasia and in WDPM display a variety of different histomorphologic features. To our knowledge, collagenous spherulosis in WDPM was not previously described or illustrated in the literature. Read More

Br J Neurosurg 2018 Dec 6:1-4. Epub 2018 Dec 6.

a Department of Neurosurgery, An Nan Hospital , China Medical University , Tainan , Taiwan.

Tonsillar herniation is a rare and seldom reported complication after lumboperitoneal (LP) shunting. There have been only few reports that have presented possible options for treatment with varying degrees of success. In this report, we describe a rare case of tonsillar herniation after LP shunting and review related literature. Read More

Zhonghua Bing Li Xue Za Zhi 2018 Dec;47(12):961-963

Nurs Res 2019 Jan/Feb;68(1):39-47

Rocío Rodríguez-Rey, PhD, is Associate Professor, Department of Psychology, Faculty of Biomedical and Health Sciences, Universidad Europea de Madrid, Spain. Helena García-Llana, PhD, is Psychology Associate Researcher, Department of Nephrology, La Paz University Hospital-IdiPAZ, Madrid, Spain. María Paz Ruiz-Álvarez, MP, is Registered Nurse, Department of Nephrology, La Paz University Hospital-IdiPAZ, Madrid, Spain. Alicia Gómez-Gómez, MP, is Registered Nurse, Department of Nephrology, Henares Hospital, Madrid, Spain. Gloria del Peso, PhD, is Nephrology Consultant, Department of Nephrology, La Paz University Hospital-IdiPAZ, Madrid Spain. Rafael Selgas, PhD, is Department Head, Department of Nephrology, La Paz University Hospital-IdiPAZ, Madrid, Spain.

Background: The Emotional State Instrument for Dialysis Patients (ES-D) is a brief semistructured questionnaire to assess emotional distress in patients undergoing dialysis. It was designed to be administered by a healthcare provider. A previous study showed preliminary indicators of its content and face validity. Read More

Clin Nucl Med 2019 Jan;44(1):40-41

Peritoneal carcinomatosis in prostate cancer is extremely rare and has been described in only few cases with high PSA level, androgen deprivation, or in symptomatic patients. To date, 2 cases of Ga-PSMA PET positive peritoneal metastases have been reported. We report a case of urachus metastases showed on Ga-PSMA PET/CT performed for biochemical recurrence with a very low PSA level at 0. Read More

J Cancer Res Ther 2018 Dec;14(Supplement):S1129-S1134

Department of Gastrointestinal Surgery, Kanagawa Cancer Center, Yokohama, Japan.

Background: The factors associated with the survival and prognosis of peritoneal cytology (CY)-positive pancreatic cancer patients who undergo curative resection followed by adjuvant chemotherapy have not been established.

Patients And Methods: Both overall survival (OS) and recurrence-free survival (RFS) were examined in 23 peritoneal CY-positive pancreatic cancer patients who underwent curative resection followed by adjuvant chemotherapy between 2005 and 2015.

Results: When the length of OS was evaluated using a log-rank test, significant differences were observed in the number of metastatic lymph nodes. Read More

Ann Surg Oncol 2018 Dec 11. Epub 2018 Dec 11.

Division of Surgical Oncology, Department of Surgery, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Background: This report describes patterns of disease recurrence after optimal cytoreduction (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) for peritoneal carcinomatosis (PC) of colorectal (CRC) and appendiceal adenocarcinoma (AC) origin.

Methods: Patients undergoing optimal CRS/HIPEC (2007-2016) at the authors' institution were retrospectively reviewed from a prospectively maintained database. Data regarding disease recurrence were analyzed. Read More

Methods Mol Biol 2019 ;1897:125-133

Department of Pathology and Laboratory Medicine, Cedars Sinai Medical Center, Los Angeles, CA, USA.

There is limited information regarding the biobanking of pleural and peritoneal fluids that might supplement storage of pulmonary and thoracic tissue biospecimens. Such fluids are sometimes collected for clinical analyses and may have uses that obviate or supplement tissue samples. There has been a growing interest in using liquid biopsies as they are less invasive and may be amenable to analyses that guide targeted therapies. Read More

Int Orthop 2018 Dec 11. Epub 2018 Dec 11.

Department of Orthopaedics, Denver Health Medical Center, 777 Bannock Street, Denver, CO, 80204, USA.

Purpose: To determine the most common injury patterns, root cause, and the frequency with which unrecognized contralateral posterior ring injury occurs in patients presenting with surgically treated pelvic fractures.

Methods: The medical records of 73 patients presenting to our level I trauma center (52 male and 21 female patients; mean age 41.8 years; range 18-89 years) with surgically treated pelvic ring fractures between January 1, 2016 and January 1, 2018 were reviewed. Read More

Biomed Res Int 2018 13;2018:8250589. Epub 2018 Nov 13.

Division of Nephrology, Chang Gung Memorial Hospital, Keelung, Taiwan.

Background: Encapsulating peritoneal sclerosis (EPS) is a rare but serious clinical complication of long-term peritoneal dialysis (PD) patients with high mortality. The purpose of this study was to assess the clinical characteristics of patients with EPS and to search for possible factors useful for EPS prevention and early diagnosis.

Method: This retrospective study was performed in a single dialysis center in Taiwan between August 1990 and April 2014. Read More

Biomed Res Int 2018 12;2018:2649585. Epub 2018 Nov 12.

Department of Nephrology, The First Affiliated Hospital, Sun Yat-Sen University, China.

Increased high mobility group box 1 (HMGB1) in dialysis effluence is associated with the presence of peritoneal dialysis-related peritonitis in patients and peritoneal dysfunction in acute peritonitis mice model, but it remains unclear whether HMGB1 is involved in peritoneal mesothelial cell injury and functions via molecular posttranslational modifications by acetylation in this process. Here we first showed correlation between HMGB1 acetylation level in dialysis effluence of patients and occurrence of Gram-negative peritonitis. The increased level of acetylated HMGB1 was similarly observed under the lipopolysaccharides (LPS) treatment in both human peritoneal mesothelial cell line (HMrSV5) and mice visceral peritoneum tissue. Read More

Oxid Med Cell Longev 2018 13;2018:6053492. Epub 2018 Nov 13.

Laboratório de Imunofarmacologia, Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro, RJ, Brazil.

The Mediterranean diet, rich in olive oil, is beneficial, reducing the risk of cardiovascular diseases and cancer. Olive oil is mostly composed of the monounsaturated fatty acid omega-9. We showed omega-9 protects septic mice modulating lipid metabolism. Read More

Nucl Med Mol Imaging 2018 Dec 11;52(6):445-452. Epub 2018 Oct 11.

1Department of Nuclear Medicine, Severance Hospital, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722 South Korea.

Purpose: This study aimed to compare the diagnostic value of F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) and magnetic resonance imaging (MRI) in the preoperative evaluation of uterine carcinosarcoma.

Methods: Fifty-four women with pathologically confirmed uterine carcinosarcoma who underwent preoperative FDG PET/CT and MRI from June 2006 to November 2016 were included. Pathologic findings from primary tumor lesions, para-aortic and pelvic lymph node (LN) areas, and peritoneal seeding lesions were compared with the FDG PET/CT and MRI findings. Read More