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Acta Biomed 2022 Jul 1;93(3):e2022176. Epub 2022 Jul 1.

Trauma Unit and Emergency Department, IRCCS Galeazzi Orthopedics Institute, Milano, Italy.

Humeral shaft fractures account for 1- 3% of all fractures and about 20-27% of those involving the humerus. In the past they were often conservatively treated, with an acceptable consolidation rate. Open reduction and internal fixation (ORIF) is the best choice in polytrauma patients, in complex or pathological fractures and in those associated with vascular injuries. Read More

Fed Pract 2022 Apr 13;39(4):168-174. Epub 2022 Apr 13.

Morsani College of Medicine, University of South Florida, Tampa, Florida.

Background: Despite limited data demonstrating altered hemodynamics in the lower extremities (LEs) among the population with spinal cord injury (SCI) and increased frequency of peripheral arterial disease (PAD), epidemiologic data are limited for amputations, a potential consequence. This study investigates the association of amputation due to vascular complications as a secondary outcome measure within the SCI population.

Methods: A retrospective cohort study was performed within a veteran population with SCI at a US Department of Veteran Affairs hospital to determine the prevalence of limb loss. Read More

J Clin Lab Anal 2022 Jun 26:e24569. Epub 2022 Jun 26.

Department of Pharmacology, Cangzhou Medical College, Cangzhou, China.

Background: Long noncoding RNA (lncRNA) cancer susceptibility candidate gene 2 (CASC2) inhibits inflammation and multi-organ dysfunction in various ways. The present study was intended to explore the potency of blood lncRNA CASC2 as a biomarker for sepsis management.

Methods: Totally, 184 sepsis patients and 30 healthy controls were enrolled. Read More

Biomedicines 2022 Jun 4;10(6). Epub 2022 Jun 4.

Department of Physiology, University of Szeged, Dóm tér 10, 6720 Szeged, Hungary.

Perineural treatment of peripheral nerves with capsaicin produces a long-lasting selective regional thermo- and chemo-analgesia and elimination of the neurogenic inflammatory response involving degeneration of nociceptive afferent fibers. In this study, we examined longitudinal changes in mustard oil-induced sensory neurogenic vasodilatation and plasma extravasation following perineural capsaicin treatment of the rat saphenous nerve utilizing scanning laser Doppler imaging and vascular labeling with colloidal silver. Capsaicin treatment resulted in a marked decrease in mustard oil-induced vasodilatation in the skin area served by the saphenous nerve. Read More

J Trauma Acute Care Surg 2022 Jul 12;93(1):38-42. Epub 2022 Apr 12.

From the Department of Surgery, Division of Trauma, Surgical Critical Care, Burns, and Acute Care Surgery, UC San Diego, San Diego, California.

Background: Traumatic brain injury (TBI) is a leading cause of morbidity and mortality in trauma patients worldwide. Brain injury is associated with significant inflammation, both within the brain and in the peripheral organs. This inflammatory response in TBI leads to a secondary injury, worsening the effects of the original brain injury. Read More

Eur J Vasc Endovasc Surg 2022 Jun 14. Epub 2022 Jun 14.

Vascular Surgery Unit, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Italy.

Objectives: Aim is to demonstrate contemporary outcomes of in situ saphenous vein bypass with the use of a valvulotome.

Design: Analysis of two-year outcomes of a multicenter registry based on the treatment of critical Limb IscheMia with infragenicular Bypass adopting in situ SAphenous VEin technique (LIMBSAVE).

Materials: Between January 2018 and December 2019 541 patients in 43 centers have been enrolled. Read More

J Am Coll Surg 2022 Jun 21;234(6):1257-1258. Epub 2022 Feb 21.

Los Angeles, CA.

Int J Mol Sci 2022 May 30;23(11). Epub 2022 May 30.

Laboratory of Histology-Embryology, School of Medicine, Faculty of Health, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.

Background: This study aims to investigate the probable lesions and injuries induced in the renal tissue after a cardiac arrest. The renal ischemia-reperfusion model in cardiac arrest describes the effects of ischemia in the kidneys, alongside a whole-body ischemia-reperfusion injury. This protocol excludes ischemic conditions caused by surgical vascular manipulation, venous injury or venous congestion. Read More

Biomed Pharmacother 2022 Jul 26;151:113172. Epub 2022 May 26.

Chinese University of Hong Kong, Hong Kong, China; School of Biomedical Sciences, Faculty of Medicine, Hong Kong, China; Shenzhen Research Institute, Chinese University of Hong Kong, Shenzhen, China. Electronic address:

Diabetic vasculopathy is a major health problem worldwide. Peripheral arterial disease (PAD), and in its severe form, critical limb ischemia is a major form of diabetic vasculopathy with limited treatment options. Existing literature suggested an important role of PPARδ in vascular homeostasis. Read More

Cell Prolif 2022 Jun 17;55(6):e13251. Epub 2022 May 17.

Cardiovascular Center, Children's Hospital of Fudan University, Shanghai, China.

Objectives: Melatonin has been reported to be an appropriate candidate for mitigating various cardiovascular injuries, owing to its versatility. This study aimed to explore the role of melatonin in Kawasaki disease (KD)-associated vasculitis and its underlying mechanisms.

Material And Methods: The role of melatonin was evaluated in human coronary artery endothelial cells (HCAECs), peripheral blood mononuclear cells from KD patients, human THP1 cell line in vitro, and a Candida albicans water-soluble fraction (CAWS)-induced KD mouse model in vivo. Read More

J Clin Med 2022 Apr 22;11(9). Epub 2022 Apr 22.

Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin 300052, China.

Background: Endoplasmic reticulum (ER) stress and unfolded protein response (UPR) is associated with neuroinflammation and subsequent cell death following traumatic brain injury (TBI). The sigma-1 receptor (Sig-1R) acts as a dynamic pluripotent modulator of fundamental cellular processes at the mitochondria-associated membranes (MAMs). The activation of Sig-1R is neuroprotective in a variety of central nervous system diseases, but its impact on ER stress induced by traumatic brain injury is not known. Read More

Front Surg 2022 20;9:862478. Epub 2022 Apr 20.

Department of Neurosurgery, University of Utah, Salt Lake City, Utah, United States.

Peripheral nerve injury is a significant public health challenge, with limited treatment options and potential lifelong impact on function. More than just an intrinsic part of nerve anatomy, the vascular network of nerves impact regeneration, including perfusion for metabolic demands, appropriate signaling and growth factors, and structural scaffolding for Schwann cell and axonal migration. However, the established nerve injury classification paradigm proposed by Sydney Sunderland in 1951 is based solely on hierarchical disruption to gross anatomical nerve structures and lacks further information regarding the state of cellular, metabolic, or inflammatory processes that are critical in determining regenerative outcomes. Read More

Inhal Toxicol 2022 22;34(5-6):145-158. Epub 2022 Apr 22.

Swedish Defence Research Agency, CBRN Defence and Security, Umeå, Sweden.

Objective: Ammonia (NH) is a corrosive alkaline gas that can cause life-threatening injuries by inhalation. The aim was to establish a disease model for NH-induced injuries similar to acute lung injury (ALI) described in exposed humans and investigate the progression of lung damage, respiratory dysfunction and evaluate biomarkers for ALI and inflammation over time.

Methods: Female BALB/c mice were exposed to an NH dose of 91. Read More

Injury 2022 Jun 6;53(6):1947-1953. Epub 2022 Apr 6.

Geriatric Research, Education & Clinical Center, South Texas Veterans Health Care System, 7400 Merton Minter Blvd, San Antonio, TX 78229 USA; Department of Surgery, University of Texas Health San Antonio, 7703 Floyd Curl Dr, San Antonio, TX 78229 USA; Departments of Primary Care & Population Health and Medical Physiology, College of Medicine, Texas A&M Health, 2900 E 29th St, Bryan, TX 77802 USA.

Objective: The high number of limb injuries among Post-9/11 Veterans and their long-term care pose significant challenges to clinicians. Current follow-up for extremity arterial vascular injury (EVI) is based on guideline-concordant care for treatment of peripheral vascular disease (GCC-PVD), including anticoagulant/antiplatelet or statin therapy and duplex ultrasound. No best practices exist for arterial EVI. Read More

Front Bioeng Biotechnol 2022 16;10:850650. Epub 2022 Mar 16.

Department of Orthopedic, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China.

An electrical signal is the key basis of normal physiological function of the nerve, and the stimulation of the electric signal also plays a very special role in the repair process of nerve injury. Electric stimulation is shown to be effective in promoting axonal regeneration and myelination, thereby promoting nerve injury repair. At present, it is considered that electric conduction recovery is a key aspect of regeneration and repair of long nerve defects. Read More

Neurosurg Clin N Am 2022 Apr 2;33(2):225-231. Epub 2022 Mar 2.

Department of Neurological Surgery, Thomas Jefferson University Hospital, 901 Walnut Street 3rd Floor, Philadelphia, PA 19107, USA. Electronic address:

After robotic systems were approved for peripheral vascular interventions, many centers adopted this technology in treating carotid diseases. Robotic systems provide several advantages by eliminating radiation exposure and decreasing the rate of musculoskeletal injuries among interventionalists. The main disadvantage this technology poses is the lack of haptic feedback. Read More

Acta Neuropathol Commun 2022 03 16;10(1):34. Epub 2022 Mar 16.

Jefferson Institute of Molecular Medicine and Scleroderma Center, Thomas Jefferson University, Philadelphia, PA, 19107, USA.

Entrapment peripheral neuropathies are clinically characterized by sensory impairment and motor deficits. They are usually caused by mechanical injuries, but they are also a frequent manifestation of metabolic diseases, toxic agent exposure, or systemic fibrotic disorders. Here we describe the clinical, radiological, and histopathological features of a novel progressive fibrotic disorder characterized by progressive multifocal fibrosing neuropathy. Read More

PLoS One 2022 14;17(3):e0264486. Epub 2022 Mar 14.

Department of Plastic, Aesthetic, Hand & Reconstructive Surgery, Hannover Medical School, Hannover, Germany.

After spinal cord injury, gliomesenchymal scaring inhibits axonal regeneration as a physical barrier. In peripheral nerve injuries, native spider silk was shown to be an effective scaffold to facilitate axonal re-growth and nerve regeneration. This study tested a two-composite scaffold made of longitudinally oriented native spider silk containing a Haemocomplettan fibrin sheath to bridge lesions in the spinal cord and enhance axonal sprouting. Read More

Heart Lung Circ 2022 Jul 8;31(7):1023-1028. Epub 2022 Mar 8.

Department of Cardiology, Carmel Medical Center, Haifa, Israel. Electronic address:

Background: Transfemoral transcatheter aortic valve replacement (TAVR) procedures require secondary vascular access for inserting accessory catheters and performing percutaneous repair of femoral artery injury. Use of the transbrachial approach for secondary vascular access in TAVR procedures has not been reported.

Methods: This study identified 48 patients at the current institution who had undergone transfemoral TAVR utilising transbrachial secondary vascular access. Read More

J Orthop 2022 Mar-Apr;30:115-119. Epub 2022 Feb 23.

Wake Forest University School of Medicine, Department of Orthopaedic Surgery and Rehabilitation, Medical Center Blvd, Winston-Salem, NC, 27157, USA.

Objectives: The ankle brachial index (ABI) is a useful tool in detection of lower extremity vascular injury. However, diabetes mellitus (DM), chronic kidney disease (CKD), and peripheral vascular disease (PVD) may affect extremity perfusion leading to possible false elevation of the ABI value. If true in trauma patients, this can affect initial evaluation, diagnostics, and management. Read More

Exp Neurol 2022 07 5;353:114029. Epub 2022 Mar 5.

Department of Cell Biology, Emory University School of Medicine, Atlanta, GA, USA. Electronic address:

Enhancing axon regeneration is a major focus of nerve injury research, and the quality of the surgical nerve repair plays a large role in the aggregate success of nerve regeneration. Additionally, exercise is known to promote successful axon regeneration after surgical nerve repair. In this study, we asked how exercise-induced nerve regeneration is affected when a transected nerve is repaired with or without fibrin glue. Read More

Indian J Orthop 2022 Mar 8;56(3):421-428. Epub 2021 Sep 8.

Department of Orthopaedics, Preethi Hospitals Pvt. Ltd., Madurai, India.

Introduction: The Achilles tendon is one of the strongest and most ruptured tendons; with no appropriate treatment it either heals in elongation or gap nonunion. Management of such chronic tears is critical and several procedures have been described. Complex gaps of over 6-8 cm need a combination technique. Read More

JNMA J Nepal Med Assoc 2022 Jan 15;60(245):12-16. Epub 2022 Jan 15.

Department of Surgery, Dhulikhel Hospital, Kathmandu University Hospital, Dhulikhel, Kavre, Nepal.

Introduction: Peripheral vascular trauma can result in limb or life-threatening injuries. Early surgical intervention leads to a better outcome. Diagnosis is made clinically, by non-invasive and invasive imaging modalities. Read More

BMC Nephrol 2022 02 22;23(1):74. Epub 2022 Feb 22.

Department of Medicine, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Ullmann 615, Bronx, NY, USA.

Background: Patients with chronic kidney disease commonly experience gait abnormalities, which predispose to falls and fall-related injuries. An unmet need is the development of improved methods for detecting patients at high risk of these complications, using tools that are feasible to implement in nephrology practice. Our prior work suggested step length could be such a marker. Read More

BMJ Open 2022 Feb 21;12(2):e047765. Epub 2022 Feb 21.

Alliance for Vascular Access Teaching and Research Group, Griffith University, Nathan, Queensland, Australia.

Introduction: Peripheral intravenous catheters (PIVCs) frequently fail during therapy administration, resulting in infusates pooling in the surrounding tissue. These extravasation injuries can cause significant pain, tissue destruction and scarring. ivWatch is a biosensor that uses visible and near-infrared light to measure tissue changes surrounding the PIVC and alert clinicians when extravasation may occur. Read More

J Surg Res 2022 06 15;274:185-195. Epub 2022 Feb 15.

Division of Trauma, Emergency Surgery, and Surgical Critical Care, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts; Center for Outcomes & Patient Safety in Surgery (COMPASS), Massachusetts General Hospital, Boston, Massachusetts. Electronic address:

Introduction: Intraoperative deaths (IODs) are rare but catastrophic. We systematically analyzed IODs to identify clinical and patient safety patterns.

Methods: IODs in a large academic center between 2015 and 2019 were included. Read More

JBJS Rev 2022 02 7;10(2). Epub 2022 Feb 7.

Department of Orthopaedic Surgery, Tulane University School of Medicine, New Orleans, Louisiana.

»: The incidence of quadriceps tendon rupture is estimated to be 1.37 cases per 100,000 people/year, with a predilection for these injuries in patients who are ≥40 years of age.

»: Quadriceps tendon ruptures are more likely to occur in the presence of preexisting comorbidities such as rheumatoid arthritis, systemic lupus erythematosus, gout, chronic kidney disease, secondary hyperparathyroidism, diabetes mellitus, and peripheral vascular disease. Read More

Cureus 2022 Jan 25;14(1):e21607. Epub 2022 Jan 25.

Physical Medicine and Rehabilitation, Hospital Senhora da Oliveira - Guimarães, Guimarães, PRT.

Traumatic knee dislocations are serious and complex injuries, defined as clinical and/or radiological loss of tibiofemoral congruence, which may represent real emergencies to the integrity of the affected limb. This lesion is responsible for multi-ligament tears but the most serious possible complications are related to vascular and peripheral nerve injuries. Recent studies show that surgical treatment has better functional results and higher return rates to sports practice compared to conservative treatment. Read More

Exp Neurol 2022 05 20;351:113989. Epub 2022 Jan 20.

Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga 4710-057, Portugal; ICVS/3B's PT Government Associate Laboratory, Braga/Guimarães, Portugal. Electronic address:

Adipose tissue derived stem cells (ASCs) are recognized to secret a myriad of molecules (secretome) know to modulate inflammatory response, promote axonal growth as well vascular remodeling and cellular survival. In previous works we have reported the benefit effects of ASCs transplanted to the injury site in a rat model of spinal cord injury (SCI). Emerging evidence have shown that the therapeutic actions of these cells are a consequence of their intense paracrine activity mediated by their secretome, which includes soluble bioactive molecules and vesicles. Read More

Sci Rep 2022 01 13;12(1):662. Epub 2022 Jan 13.

Clem Jones Centre for Neurobiology and Stem Cell Research, Griffith University, Nathan, QLD, Australia.

Peripheral glial cell transplantation with Schwann cells (SCs) is a promising approach for treating spinal cord injury (SCI). However, improvements are needed and one avenue to enhance regenerative functional outcomes is to combine growth factors with cell transplantation. Vascular endothelial growth factor (VEGF) and platelet-derived growth factor (PDGF) are neuroprotective, and a combination of these factors has improved outcomes in rat SCI models. Read More