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Neural Regen Res 2019 Jun;14(6):984-990

Department of Neurosurgery, Tianjin Medical University General Hospital; Tianjin Neurological Institute; Key Laboratory of Post-trauma Neuro-repair and Regeneration in Central Nervous System, Ministry of Education; Tianjin Key Laboratory of Injuries, Variations and Regeneration of Nervous System, Tianjin, China.

Hyperglycemia reduces the number of circulating endothelial progenitor cells, accelerates their senescence and impairs their function. However, the relationship between blood glucose levels and endothelial progenitor cells in peripheral blood of patients with traumatic brain injury is unclear. In this study, 101 traumatic brain injury patients admitted to the Department of Neurosurgery, Tianjin Medical University General Hospital or the Department of Neurosurgery, Tianjin Huanhu Hospital, China, were enrolled from April 2005 to March 2007. Read More

Ann Vasc Surg 2019 Feb 4. Epub 2019 Feb 4.

Interventional Radiology Department, AORN "A. Cardarelli", Via A. Cardarelli 9, 80131 Naples, Italy.

Aim: Vascular Blowout Syndrome (VBOS) is a life-threatening condition secondary to direct tumor encasement or invasion in advanced stage malignancies. Endovascular management can be an alternative to surgical treatment in this fragile patient population providing a minimally invasive measure both acutely and prophylactically.

Materials And Methods: Three patients with peripheral VBOS secondary to advanced stage malignancies underwent successful endovascular treatment. Read More

Ann Vasc Surg 2019 Jan 23. Epub 2019 Jan 23.

David Geffen School of Medicine at UCLA, Los Angeles, CA; Harbor-UCLA Medical Center, Department of Surgery, Torrance, CA. Electronic address:

Background: Early identification of peripheral vascular injuries is crucial to prevent acute limb ischemia and amputation. We sought to identify predictors of vascular injury in patients with blunt lower extremity fractures.

Methods: A single institutional retrospective analysis of patients with blunt lower extremity fractures at a university-affiliated, County hospital over a 2-year period was performed. Read More

Rozhl Chir 2018 ;97(12):558-562

Introduction: This work provides an overview of the incidence of gunshot wounds during peace conditions in a civilian population and aims to assess the principles of their treatment.

Method: We evaluated a total of 104 patients with gunshot wounds with an average age of 38.7 years (range 1871). Read More

J Orthop Sci 2019 Jan 7. Epub 2019 Jan 7.

Department of Orthopaedic Surgery, Graduate School of Biomedical & Health Sciences, Hiroshima University, 1-2-3 Kasumi Minamiku, Hiroshima city, 734-8551, Japan.

Background: Arthroscopic ankle arthrodesis (AAA) is minimally invasive surgery, whereby percutaneous screw fixation is used through the medial aspect of the distal tibia to fusion the ankle, but it carries the risk of the saphenous vein and nerve injuries. The near-infrared (NIR) vascular imaging system, the VeinViewer Flex, projects an image of the vein onto the skin, and the visualization of the vein may reduce the vein and nerve injuries. The purpose of this study is to investigate the risk of the saphenous vein injury by the percutaneous screw insertion during AAA, and to evaluate the effectiveness of the NIR vascular imaging system in the reduction of the saphenous vein injury. Read More

J Vasc Surg 2018 Nov 26. Epub 2018 Nov 26.

Edward Hébert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Md.

Background: Six hours has long been considered the threshold of ischemia after peripheral artery injury. However, there is a paucity of evidence regarding the impact of operative delays on morbidity and mortality in patients with lower extremity arterial injuries.

Methods: We analyzed the records of 3,441,259 injured patients entered into the National Trauma Data Bank Research Dataset from 2012 to 2015. Read More

Rev Esp Cir Ortop Traumatol 2019 Jan - Feb;63(1):24-28. Epub 2018 Nov 24.

Departamento de Ortopedia y Traumatología Infantil, Sanatorio Allende, Córdoba, Argentina.

Background: Some authors have suggested that the diminished vascular blood supply, peripheral stability and thickness of the discoid meniscus (DM) would make it more prone to tears. The aims of this study are two-fold: 1) To analyse morphological characteristics by magnetic resonance (MRI), and 2) To correlate the size of the meniscus with the presence of meniscal tears.

Methods: The MRI of patients ≤18 years-old over a period of 5 years were reviewed, and patients with DM were identified. Read More

BMC Musculoskelet Disord 2018 Nov 20;19(1):404. Epub 2018 Nov 20.

Department for General Visceral, Vascular & Paediatric Surgery, University Hospital Würzburg, Würzburg, Germany.

Background: Vascular damage in polytrauma patients is associated with high mortality and morbidity. Therefore, specific clinical implications of vascular damage with fractures in major trauma patients are reassessed.

Methods: This comprehensive nine-year retrospective single center cohort study analyzed demography, laboratory, treatment and outcome data from 3689 patients, 64 patients with fracture-associated vascular injuries were identified and were compared to a control group. Read More

Med Sci Monit 2018 Nov 19;24:8322-8332. Epub 2018 Nov 19.

The First Department of Endocrinology, Tai'an Central Hospital, Tai'an, Shandong, China (mainland).

BACKGROUND This study investigated the distribution and features of natural killer T (NKT) cells in the peripheral blood of diabetic patients, and their regulatory roles on vascular endothelial cells. MATERIAL AND METHODS Peripheral lymphocytes were isolated from diabetic patients. NKT cell distribution, proportion, and surface and intracellular markers were detected with flow cytometry. Read More

Int J Surg Case Rep 2018 2;53:285-290. Epub 2018 Nov 2.

Department of Orthopaedic & Traumatology, Cipto Mangunkusumo National Central Hospital/Faculty of Medicine, Universitas Indonesia, Indonesia.

Introduction: Combined injuries of peripheral nerve of upper extremity are usually the result of severe trauma to the extremity, and are often associated with substantial soft tissue, vascular, and bony injuries. The most common form of such combined injury is a low median-ulnar palsy, usually due to laceration of the volar wrist. It is a devastating injury, and with delayed presentation the injury is going to be more difficult to reconstruct. Read More

Sci Rep 2018 Nov 13;8(1):16716. Epub 2018 Nov 13.

Department of Biology, Lund University, SE-223 62, Lund, Sweden.

Electrospinning can be used to mimic the architecture of an acellular nerve graft, combining microfibers for guidance, and pores for cellular infiltration. We made electrospun nerve guides, from polycaprolactone (PCL) or poly-L-lactic acid (PLLA), with aligned fibers along the insides of the channels and random fibers around them. We bridged a 10 mm rat sciatic nerve defect with the guides, and, in selected groups, added a cell transplant derived from autologous stromal vascular fraction (SVF). Read More

Inj Epidemiol 2018 Nov 12;5(1):42. Epub 2018 Nov 12.

Department of Rehabilitation and Regenerative Medicine, Columbia University Medical Center, New York, NY, USA.

Background: People with lower limb loss that live in the community fall at a rate that exceeds that of other vulnerable populations such as hospitalized elderly people. Past research in a small single state study has identified factors associated with fall-related injury. The purpose of this study was to use a larger multistate sample of people with lower limb loss living in community settings to evaluate factors associated with fall-related injury in a multivariable model. Read More

Ostomy Wound Manage 2018 Nov;64(11):30-41

Skin Population, Department of Nursing, Mayo Clinic, Rochester, MN.

Preventing, identifying, and treating deep tissue injury (DTI) remains a challenge.

Purpose: The purpose of the current research was to describe the characteristics of DTIs and patient/care variables that may affect their development and outcomes at the time of hospital discharge.

Methods: A retrospective, descriptive, single-site cohort study of electronic medical records was conducted between October 1, 2010, and September 30, 2012, to identify common demographic, intrinsic (eg, mobility status, medical comorbidities, and incontinence), extrinsic (ie, surgical and procedural events, medical devices, head-of-bed elevation), and care and treatment factors related to outcomes of hospital-acquired DTIs; additional data points related to DTI development or descriptive of the sample (Braden Scale scores and subscale scores, hospital length of stay [LOS], intensive care unit [ICU] LOS, days from admission to DTI, time in the operating room, serum albumin levels, support surfaces/specialty beds, and DTI locations) also were retrieved. Read More

Ann Vasc Dis 2018 Sep;11(3):377-397

This is an annual report indicating the number and early clinical results of annual vascular treatments performed by vascular surgeons in Japan during 2011, as analyzed by database management committee (DBC) members of the Japanese Society for Vascular Surgery (JSVS). : To survey the current status of vascular treatments performed by vascular surgeons in Japan, the DBC members of the JSVS analyzed the vascular treatment data provided from National Clinical Database (NCD), including the number of treatments and early clinical results such as operative and in-hospital mortality. Given that NCD data were prospectively built by a nationwide registration, this annual report reports prospective clinical data. Read More

Asian J Surg 2018 Nov 2. Epub 2018 Nov 2.

Divisions of Vascular Surgery, Pediatric Surgery, Emergency Medicine, General Surgery, Department of Surgery, College of Medicine, King Faisal University, Al-Ahsa, Saudi Arabia.

Objectives: To evaluates the management and outcome of non-iatrogenic pediatric and adolescence extremity arterial injuries in a resource-challenged setting.

Methods: A retrospective study of the surgical management for non-iatrogenic extremity arterial trauma in pediatric and adolescence during the period from January 2008 to December 2015. This study was performed in two different countries at tertiary referral university and teaching hospitals having a specialized emergency and trauma centers. Read More

Pediatr Nephrol 2018 Nov 3. Epub 2018 Nov 3.

Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

Ischemia reperfusion (IR) injury is a process defined by the temporary loss of blood flow and tissue perfusion followed later by restoration of the same. Brief periods of IR can be tolerated with little permanent deficit, but sensitivity varies for different target cells and tissues. Ischemia reperfusion injuries have multiple causes including peripheral vascular disease and surgical interventions that disrupt soft tissue and organ perfusion as occurs in general and reconstructive surgery. Read More

Zhonghua Xin Xue Guan Bing Za Zhi 2018 Oct;46(10):804-809

Department of Cardiothoracic Surgery, Dalian Children's Hospital, Dalian 116012, China.

To investigate the safety and efficacy of percutaneous intervention of children with combined congenital heart abnormality solely guided by transthoracic echocardiography (TTE) . From September 2015 to June 2017, 21 children with combined congenital heart abnormality undergoing percutaneous interventional guided by TTE in Fuwai hospital were enrolled in our study, and the clinical data were retrospective analyzed. The atrial septal defect(ASD) closure, ventricular septal defect(VSD) closure, patent ductus arteriosus(PDA) closure or balloon pulmonary valvuloplasty were performed under the guidance of TTE. Read More

Ann Vasc Surg 2018 Oct 18. Epub 2018 Oct 18.

Department of Endovascular and Vascular Surgery, Hospital Universitari de Bellvitge, Hospitalet de Llobregat, Barcelona, Spain; IDIBELL, Institut Investigació Biomèdica de Bellvitge, Hospitalet de Llobregat, Barcelona, Spain.

Background: Endovascular surgery has become the initial treatment for most patients with chronic ischemia of the lower limbs. Few studies support ultrasound surveillance (US) of this kind of procedures. The purpose of this study was to evaluate the initial efficacy of duplex ultrasound as a surveillance method in endovascular treatment in symptomatic peripheral arterial disease patients in our center. Read More

Ann Vasc Surg 2018 Oct 18. Epub 2018 Oct 18.

Division of Plastic and Reconstructive Surgery, University of Colorado School of Medicine, Aurora, CO. Electronic address:

Background: The radial approach to cardiac procedures has become increasingly common. Although previous studies have suggested a favorable risk profile, serious complications can occur. The purpose of this study is to examine the incidence, subsequent treatment, and outcome of all suspected significant neurovascular complications following transradial cardiac procedures at a large US hospital. Read More

J Ultrason 2018 ;18(73):166-169

Department of Interventional Radiology and Neuroradiology, Medical University of Lublin, Lublin, Poland.

External injuries are one of the common reasons for reporting to hospital emergency departments. Peripheral vascular injuries occur in up to about 25% of upper and lower extremity injury cases. Arteriovenous fistula is a type of arterial injury. Read More

Vasa 2019 Jan 17;48(1):65-71. Epub 2018 Oct 17.

2 Division of Interventional Radiology, Medical College of Wisconsin, Milwaukee, USA.

Although management paradigms for certain arterial trauma, such as aortic injuries, have moved towards an endovascular approach, the application of endovascular techniques for the treatment of peripheral arterial injuries continues to be debated. In the realm of peripheral vascular trauma, popliteal arterial injuries remain a devastating condition with significant rates of limb loss. Expedient management is essential and surgical revascularization has been the gold standard. Read More

Vasc Health Risk Manag 2018 28;14:247-251. Epub 2018 Sep 28.

Immunology Research Center, Inflammation and Inflammatory Diseases Division, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran,

Background: The possible role of infectious pathogens in the development of thromboangiitis obliterans (TAO) was considered soon after the disease was first described. However, it is not yet known whether infectious pathogens induce thrombotic vasculitis or if they cause a type of autoimmune disease. To investigate whether TAO relapses are more likely due to reinfection or autoimmune flare, the serum levels of toll-like receptor (sTLR) 4, sTLR2, C-reactive protein (CRP), and neopterin were evaluated in TAO patients during both the acute and quiescent phases of the disease as well as in a gender-, age-, and smoking habit-matched control group. Read More

J Vasc Surg 2018 Oct 3. Epub 2018 Oct 3.

Division of Pediatric Surgery, Department of Surgery, Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, Ind.

Objective: The purpose of this investigation was to determine our limb-related contemporary pediatric revascularization perioperative and follow-up outcomes after major blunt and penetrating trauma.

Methods: A retrospective review was performed of a prospectively maintained pediatric trauma database spanning January 2010 to December 2017 to capture all level I trauma activations that resulted in a peripheral arterial revascularization procedure. All preoperative, intraoperative, and postoperative continuous variables are reported as a mean ± standard deviation; categorical variables are reported as a percentage of the population of interest. Read More

Hand Clin 2018 Nov 20;34(4):503-510. Epub 2018 Aug 20.

Department of Orthopaedic Surgery, Nicklaus Children's Hospital, 3100 Southwest 62nd Avenue, Miami, FL 33155, USA.

A spastic limb refers to one with increased tone. This commonly results from an upper motor neuron injury, which, in turn, leads to disinhibition of reflex arcs. At the level of the elbow, affected individuals typically exhibit a flexion posture secondary to spastic contracture of the biceps, brachialis, and brachioradialis muscles. Read More

J Physiol Anthropol 2018 Sep 29;37(1):22. Epub 2018 Sep 29.

Laboratory of Environmental Physiology, Faculty of Environmental and Symbiotic Sciences, Prefectural University of Kumamoto, Kumamoto, Japan.

Background: We investigated cardiovascular responses to an orthostatic challenge in trained spinal cord-injured (SCI) individuals compared to able-bodied (AB) individuals.

Methods: A total of 23 subjects participated, divided into three groups: seven were trained as spinal cord-injured (Tr-SCI) individuals, seven were able-bodied individuals trained as runners (Tr-AB), and nine were untrained able-bodied individuals (UnTr-AB). We measured the cardiovascular autonomic responses in all three groups during each 5-min head-up tilt (HUT) of 0°, 40°, and 80°. Read More

Am J Physiol Regul Integr Comp Physiol 2018 Nov 26;315(5):R1054-R1060. Epub 2018 Sep 26.

University of Texas Southwestern Medical Center and Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital , Dallas, Texas.

The effect of severe burn injury on vascular health is unknown. We tested the hypothesis that, compared with nonburn control subjects, vasodilator function would be reduced and that pulse-wave velocity (a measure of arterial stiffness) would be increased in individuals with prior burn injuries, the extent of which would be associated with the magnitude of body surface area having sustained a severe burn. Pulse-wave velocity and macrovascular (flow-mediated dilation) and microvascular (reactive hyperemia) dilator functions were assessed in 14 nonburned control subjects and 32 age-matched subjects with well-healed burn injuries. Read More

Sci Rep 2018 Sep 18;8(1):14004. Epub 2018 Sep 18.

Wellman Center for Photomedicine, Massachusetts General Hospital, 40 Blossom St., Boston, Massachusetts, 02114, USA.

Severe peripheral nerve injuries often result in partial repair and lifelong disabilities in patients. New surgical techniques and better graft tissues are being studied to accelerate regeneration and improve functional recovery. Currently, limited tools are available to provide in vivo monitoring of changes in nerve physiology such as myelination and vascularization, and this has impeded the development of new therapeutic options. Read More

Neurorehabil Neural Repair 2018 09;32(9):765-776

2 University of Maryland School of Medicine, Baltimore, MD, USA.

Peripheral nerve injury is a major clinical problem and often results in a poor functional recovery. Despite obvious clinical need, treatment strategies have been largely suboptimal. In the nervous system, exosomes, which are nanosized extracellular vesicles, play a critical role in mediating intercellular communication. Read More

Elife 2018 09 17;7. Epub 2018 Sep 17.

Laboratory of Molecular Neurobiology, Neurobiology Center, Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw, Poland.

Following CNS demyelination, oligodendrocyte progenitor cells (OPCs) are able to differentiate into either remyelinating oligodendrocytes (OLs) or remyelinating Schwann cells (SCs). However, the signals that determine which type of remyelinating cell is generated and the underlying mechanisms involved have not been identified. Here, we show that distinctive microenvironments created in discrete niches within demyelinated white matter determine fate decisions of adult OPCs. Read More

Scand J Trauma Resusc Emerg Med 2018 Sep 10;26(1):76. Epub 2018 Sep 10.

Institute for Research in Operative Medicine (IFOM), University of Witten / Herdecke, Cologne, Germany.

Background: Peripheral nerve injury (PNI) as an adjunct lesion in patients with upper extremity trauma has not been investigated in a Central European setting so far, despite of its devastating long-term consequences. This study evaluates a large multinational trauma registry for prevalence, mechanisms, injury severity and outcome characteristics of upper limb nerve lesions.

Methods: After formal approval the TraumaRegister DGU® (TR-DGU) was searched for severely injured cases with upper extremity involvement between 2002 and 2015. Read More

Spinal Cord Ser Cases 2018 24;4:78. Epub 2018 Aug 24.

4Department of Physical Medicine and Rehabilitation, King Fahad Specialist Hospital, Dammam, Saudi Arabia.

Study Design: Retrospective study.

Objective: To identify demographic features, clinical characteristics, and complications associated with spinal cord injuries/disorders (SCI/D) among elderly individuals at a rehabilitation hospital and to measure the functional outcomes of rehabilitation.

Setting: Rehabilitation hospital in King Fahad Medical City (KFMC), Riyadh, Saudi Arabia. Read More

J Vasc Interv Radiol 2018 09;29(9):1281-1283

Department of Radiology, Erasmus MC University Medical Center, Gravendijkwal 230, 3015 CE, Rotterdam, The Netherlands.

High Alt Med Biol 2018 Dec 22;19(4):388-393. Epub 2018 Aug 22.

1 Warwick Medical School, University of Warwick , Coventry, United Kingdom .

Frostbite and other cold-related injuries commonly develop during prolonged exposure to the low environmental temperatures of polar and mountainous regions. Hypoxia is a potent sympathetic stimulus that causes vasoconstriction of the peripheral blood vessels, which may further compound the risk of developing a cold-related injury during high-altitude exposure. To investigate this, we utilized portable infrared thermographic technology to quantitatively measure changes in the surface temperature of the hands during exposure to increasing levels of normobaric hypoxia in a temperature-controlled high-altitude simulation. Read More

Wound Repair Regen 2018 Nov 25;26(6):446-455. Epub 2018 Oct 25.

Department of Plastic and Reconstructive Surgery, Tokyo Women's Medical University, Tokyo, Japan.

Adipose-derived stem cells (ADSCs) and the stromal vascular fraction (SVF) promote nerve regeneration. Biodegradable nerve conduits are used to treat peripheral nerve injuries, but their efficiencies are lower than those of autologous nerve grafts. This study developed biodegradable nerve conduits containing ADSCs and SVF and evaluated their facial nerve regenerating abilities in a rat model with a 7-mm nerve defect. Read More

Acta Neurochir (Wien) 2018 Sep 29;160(9):1837-1845. Epub 2018 Jul 29.

School of Medicine, University of Belgrade, Belgrade, Serbia.

Background: Traumatic brachial plexus injuries are generally severe, and in many cases associated with surrounding tissue injuries, which makes them hard to diagnose at the right time. This paper presents etiological and epidemiological characteristics of surgically treated civilian traumatic brachial plexus injuries.

Methods: This retrospective study included 68 patients, operated due to the traumatic brachial plexus injuries at Clinic for Neurosurgery, Clinical Center of Serbia, during the 11-year period. Read More

Br J Radiol 2018 Nov 13;91(1091):20180176. Epub 2018 Aug 13.

1 Clinic of Vascular Surgery, National Cardiology Hospital , Sofia , Bulgaria.

Objective:: Hybrid surgical methods such as remote endarterectomy and endovascular revascularization are fluoroscopy-guided procedures successfully replacing conventional open surgery for treatment of peripheral artery disease (PAD). The aim of this study was to: (1) evaluate the dose parameters describing exposure of patients undergoing endovascular or hybrid revascularization of the lower limb (below the inguinal ligament); (2) compare the data available in the literature with the evaluations of patients' dose values and related factors for patients undergoing such procedures; (3) examine the correlation of doses with certain parameters; (4) estimate the peak skin dose and assess the potential for radiation-induced skin injuries during the procedures.

Methods:: Data for 259 patients were extracted retrospectively and analyzed. Read More

Biomaterials 2018 Oct 2;179:175-185. Epub 2018 Jul 2.

Department of BIN Convergence Technology, Chonbuk National University, Baekjedaero 567, Jeonju, Chonbuk, 54896, Republic of Korea; Department of Polymer⋅Nano Science and Technology, Chonbuk National University, Baekjedaero 567, Jeonju, Chonbuk, 54896, Republic of Korea. Electronic address:

Muscles of peripheral artery disease (PAD) patients are under oxidative stress associated with a significantly elevated level of reactive oxygen species (ROS) including hydrogen peroxide (HO). Curcumin is a major active constituent of turmeric and is well known for its highly potent antioxidant, anti-inflammatory and angiogenic effects. We previously reported antioxidant vanillyl alcohol-incorporated copolyoxalate (PVAX) which is designed to rapidly scavenge HO and release bioactive vanillyl alcohol and CO in a HO-triggered manner. Read More

Mol Pain 2018 Jan-Dec;14:1744806918789812. Epub 2018 Jul 3.

1 Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Japan.

Background Diabetic peripheral neuropathy is a common long-term complication of diabetes. Accumulating evidence suggests that vascular impairment plays important roles in the pathogenesis of diabetic peripheral neuropathy, while the mechanism remains unclear. We recently reported that transient receptor potential ankyrin 1 (TRPA1) is sensitized by hypoxia, which can contribute to cold hypersensitivity. Read More

J Invasive Cardiol 2018 07;30(7):240-244

Midwest Cardiovascular Research Foundation, 1622 E. Lombard Street, Davenport, IA 52803 USA.

Background: Dissections occur post atherectomy of the infrainguinal arteries. We hypothesized that angiography under-estimates their presence significantly.

Methods: In this prospective pilot study, a total of 15 patients were evaluated by intravascular ultrasound (IVUS) following treatment of femoropopliteal de novo or non-stent restenosis using atherectomy. Read More

J Reconstr Microsurg 2018 Oct 26;34(8):632-641. Epub 2018 Jun 26.

Department of Plastic, Aesthetic, Reconstructive and Hand Surgery, Evangelisches Krankenhaus Oldenburg, Medical Campus University of Oldenburg, Oldenburg, Germany.

Background:  The composite anterolateral thigh flap with vascularized fascia lata (ALT-FL flap) for covering complex soft tissue defects involving the Achilles tendon has shown promising results. The age and body mass index (BMI) are important predictors of clinical outcome after surgical treatment of Achilles tendon ruptures. In this study, we investigate whether these also influence the outcome of patients after Achilles tendon reconstruction using the ALT-FL flap. Read More

Biomater Sci 2018 Jul;6(8):2059-2072

Engineering Research Center of Cell & Therapeutic Antibody, Ministry of Education, and School of Pharmacy, Shanghai Jiao Tong University, No. 800 Dongchuan RD, Shanghai 200240, China.

Non-viral vector gene delivery is generally limited by its potential toxicity problems, poor transfection abilities, serum stability, or relatively complex construction processes of modified polyplexes. Thus, we develop an efficient and stable polyplex system through convenient construction methods. Here, polyethyleneimine (PEI) 1. Read More

Angiol Sosud Khir 2018;24(2):195-200

Railway Clinical Hospital at the Chelyabinsk Station of the Open Joint-Stock Company 'Russian Railways', Chelyabinsk, Russia; South Ural State Medical University of the RF Ministry of Public Health, Chelyabinsk, Russia.

The purpose of the study was to elaborate an algorithm of treatment policy for post-puncture false aneurysms of the femoral artery (FAFA). The study was performed on the basis of the clinical material over 2014-2017 at the Regional Vascular Centre whose specialists have since 2017 been using the femoral arterial approach (FAA) only if the radial arteries are inaccessible for puncture or for inserting the endovascular tools and appliances. The obtained findings demonstrated that the number of coronary interventions performed with the use of the femoral arterial approach in patients presenting with acute coronary syndrome decreased from a total of 758 (100. Read More

Biomaterials 2018 Sep 6;178:109-121. Epub 2018 Jun 6.

John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, 02138, USA; Wyss Institute Biologically Inspired Engineering, Harvard University, Boston, MA, 02115, USA. Electronic address:

Ischemic diseases, such as peripheral artery disease, affect millions of people worldwide. While CD4 T-cells regulate angiogenesis and myogenesis, it is not understood how the phenotype of these adaptive immune cells regulate these regenerative processes. The secreted factors from different types of CD4 T-cells (Th1, Th2, Th17, and Treg) were utilized in a series of in vitro assays and delivered from an injectable alginate biomaterial into a murine model of ischemia to study their effects on vascular and skeletal muscle regeneration. Read More

J Clin Lab Anal 2018 Oct 11;32(8):e22569. Epub 2018 Jun 11.

Department of interventional and vascular Surgery, Tenth people's Hospital of Tongji University, Shanghai, China.

Background: The goal of this study was to characterize the properties of human CD34 cells in culture and investigate the feasibility and efficacy of CD34 transplantation in a mouse model of limb ischemia and in patients with no-option critical limb ischemia.

Methods: Human CD34 cells isolated from peripheral blood and grown in culture for up to four passages stained positively for the surface markers CD34 and CD133 and showed high viability after cryopreservation and recovery. Seven days after surgery to induce limb ischemia, ischemic muscles of nude mice were injected with CD34 cells. Read More

Front Neurosci 2018 23;12:341. Epub 2018 May 23.

Department of Anesthesiology, Xiangya Hospital of Central South University, Changsha, China.

Peripheral nerve injuries are generally associated with incomplete restoration of motor function. The slow rate of nerve regeneration after injury may account for this. Although many benefits of resveratrol have been shown in the nervous system, it is not clear whether resveratrol could promote fast nerve regeneration and motor repair after peripheral nerve injury. Read More

Acta Biomater 2018 07 31;75:235-252. Epub 2018 May 31.

Institute of Biomechanics, Graz University of Technology, Austria; Faculty of Engineering Science and Technology, Norwegian University of Science and Technology, Trondheim, Norway. Electronic address:

Peripheral vascular trauma due to injuries of the upper and lower limbs are life-threatening, and their treatment require rapid diagnosis and highly-qualified surgical procedures. Experienced surgeons have recognized that subclavian arteries, affected by injuries of the upper limbs, require a more careful handling due to fragility than common iliac arteries, which are may be affected by injures of the lower limbs. We investigated these two artery types with comparable diameter to evaluate the differences in the biomechanical properties between subclavian and iliac arteries. Read More

Int Arch Occup Environ Health 2018 10 28;91(7):785-797. Epub 2018 May 28.

Department of Public Health and Clinical Medicine, Occupational and Environmental Medicine, Umeå University, 901 87, Umeå, Sweden.

Purpose: To identify factors associated with the reporting of cold sensitivity, by comparing cases to controls with regard to anthropometry, previous illnesses and injuries, as well as external exposures such as hand-arm vibration (HAV) and ambient cold.

Methods: Through a questionnaire responded to by the general population, ages 18-70, living in Northern Sweden (N = 12,627), cold sensitivity cases (N = 502) and matched controls (N = 1004) were identified, and asked to respond to a second questionnaire focusing on different aspects of cold sensitivity as well as individual and external exposure factors suggested to be related to the condition. Conditional logistic regression analyses were performed to determine statistical significance. Read More

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2018 Apr;32(4):385-388

Department of Orthopedics, West China Hospital, Sichuan University, Chengdu Sichuan, 610041,

Objective: To explore the mid-term effectiveness of total hip arthroplasty (THA) with subtrochanteric shortening osteotomy in treatment of Crowe type Ⅳ developmental dysplasia of the hip (DDH).

Methods: Between September 2009 and March 2014, a total of 49 patients (57 hips) who were diagnosed with Crowe type Ⅳ DDH were treated with THA and subtrochanteric shortening osteotomy. Of the 49 patients, 7 were male and 42 were female with an average age of 44. Read More

World Neurosurg 2018 Aug 23;116:e791-e800. Epub 2018 May 23.

Division of Pediatric Neurosurgery, Gazi University Faculty of Medicine, Ankara, Turkey.

Background: Stereotactic radiosurgery (SRS) is widely used to treat brain pathologies alone or in concert with other treatment modalities. However, there are some side effects, such as radiation injury characterized by edema and necrosis in peripheral tissues, that must be managed. A new treatment agent against this side effect is bevacizumab, which targets increased vascular endothelial growth factor (VEGF) as a prominent etiologic factor in radiation injury. Read More